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https://www.readbyqxmd.com/read/29062322/whole-gene-deletion-of-ebf3-supporting-haploinsufficiency-of-this-gene-as-a-mechanism-of-neurodevelopmental-disease
#1
Fátima Lopes, Gabriela Soares, Miguel Gonçalves-Rocha, Jorge Pinto-Basto, Patrícia Maciel
Mutations in early B cell factor 3 (EBF3) were recently described in patients with a neurodevelopmental disorder (NDD) that includes developmental delay/intellectual disability, ataxia, hypotonia, speech impairment, strabismus, genitourinary abnormalities, and mild facial dysmorphisms. Several large 10q terminal and interstitial deletions affecting many genes and including EBF3 have been described in the literature. However, small deletions (<1 MB) affecting almost exclusively EBF3 are not commonly reported...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29018774/influenza-a-virus-as-a-predisposing-factor-for-cryptococcosis
#2
Lorena V N Oliveira, Marliete C Costa, Thaís F F Magalhães, Rafael W Bastos, Patrícia C Santos, Hellem C S Carneiro, Noelly Q Ribeiro, Gabriella F Ferreira, Lucas S Ribeiro, Ana P F Gonçalves, Caio T Fagundes, Marcelo A Pascoal-Xavier, Julianne T Djordjevic, Tania C Sorrell, Daniele G Souza, Alexandre M V Machado, Daniel A Santos
Influenza A virus (IAV) infects millions of people annually and predisposes to secondary bacterial infections. Inhalation of fungi within the Cryptococcus complex causes pulmonary disease with secondary meningo-encephalitis. Underlying pulmonary disease is a strong risk factor for development of C. gattii cryptococcosis though the effect of concurrent infection with IAV has not been studied. We developed an in vivo model of Influenza A H1N1 and C. gattii co-infection. Co-infection resulted in a major increase in morbidity and mortality, with severe lung damage and a high brain fungal burden when mice were infected in the acute phase of influenza multiplication...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28955754/suppression-of-mage-a10-alters-the-metastatic-phenotype-of-tongue-squamous-cell-carcinoma-cells
#3
Bruna Dos Santos Mendonça, Michelle Agostini, Iara Gonçalves Aquino, Wagner Barbosa Dias, Débora Campanella Bastos, Franklin D Rumjanek
MAGE-A10 is a member of the MAGE protein family (melanoma associated antigen) which is overexpressed in cancer cells. Although MAGE-A10 has been characterized for some time and is generally associated to metastasis its function remains unknown. Here we describe experiments using as models oral squamous cell carcinoma (OSCC) cell lines displaying increasing metastatic potential (LN1 and LN2). These cell lines were transduced with lentivirus particles coding for short hairpin against MAGE-A10 mRNA. Repression of MAGE-A10 expression in LN2 cells altered their morphology and impaired growth of LN1 and LN2 cell lines...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28925336/commentary-new-tools-on-the-horizon-to-assess-the-accuracy-of-aortic-stent-graft-deployment
#4
Frederico Bastos Gonçalves, Hence J M Verhagen
No abstract text is available yet for this article.
October 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28899536/utility-of-new-generation-pacemakers-in-sleep-apnea-screening
#5
Margarida Dias, Inês Gonçalves, Bruno Amann, Pedro Marques, Cristina Martinho, Catarina Leitão, Rita Pinto Basto, João de Sousa, Paula Pinto, Cristina Bárbara
OBJECTIVE: Patients with cardiac pacemakers present a high prevalence of undiagnosed sleep apnea syndrome (SAS). New-generation pacemakers have algorithms that identify sleep respiratory events. Our aim was to evaluate their accuracy in the diagnosis of SAS. METHODS: We performed a prospective study that included patients with new-generation pacemakers (Reply 200 pacemakers). All patients underwent a polysomnography (PSG). On the same night, the respiratory disturbance index of the PSG (RDI-PSG) and of the pacemaker (RDI-PM) were recorded...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28856330/iliac-artery-reconstruction-with-femoral-vein-after-bare-metal-stent-infection
#6
A Quintas, G Alves, J Aragão de Morais, F Bastos Gonçalves, J Albuquerque E Castro, L Mota Capitao
INTRODUCTION: Primary infection of a bare metal stent is a rare condition, associated with significant morbidity and mortality. Definitive treatment includes stent removal and arterial reconstruction. REPORT: This study details a common iliac stent infection after re-intervention for iliac stent occlusion, complicated by pseudoaneurysm formation and septic embolisation. Potential risk factors for stent infection were identified. An open surgical resection of the affected artery along with all stent material was performed, followed by reconstruction with autologous interposition superficial femoral vein...
2017: EJVES Short Rep
https://www.readbyqxmd.com/read/28832804/complex-karyotype-including-ring-chromosome-11-in-a-patient-with-acute-myeloid-leukemia-case-report
#7
Maria Helena Faria Ornellas, Maria Christina Paixão Maioli, Stella Beatriz Sampaio Gonçalves de Lucena, Elenice Ferreira Bastos, Tatiana Silva Chaves, Karina Vieira de Melo, Marilza de Moura Ribeiro-Carvalho, Thomas Liehr, Gilda Alves
CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13)...
August 21, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28759591/genome-wide-diversity-and-differentiation-in-new-world-populations-of-the-human-malaria-parasite-plasmodium-vivax
#8
Thais C de Oliveira, Priscila T Rodrigues, Maria José Menezes, Raquel M Gonçalves-Lopes, Melissa S Bastos, Nathália F Lima, Susana Barbosa, Alexandra L Gerber, Guilherme Loss de Morais, Luisa Berná, Jody Phelan, Carlos Robello, Ana Tereza R de Vasconcelos, João Marcelo P Alves, Marcelo U Ferreira
BACKGROUND: The Americas were the last continent colonized by humans carrying malaria parasites. Plasmodium falciparum from the New World shows very little genetic diversity and greater linkage disequilibrium, compared with its African counterparts, and is clearly subdivided into local, highly divergent populations. However, limited available data have revealed extensive genetic diversity in American populations of another major human malaria parasite, P. vivax. METHODS: We used an improved sample preparation strategy and next-generation sequencing to characterize 9 high-quality P...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28694280/expanding-primary-care-access-a-telehealth-success-story
#9
M R Gonçalves, R N Umpierre, O P D'Avila, N Katz, S S Mengue, A C S Siqueira, V C Carrard, C A A Schmitz, C G Molina-Bastos, D V Rados, M R Agostinho, E B Oliveira, R Roman, J Basso, J N Pfeil, M V A Mendonça, R G Moro, T Frank, P L Stürmer, E Harzheim
No abstract text is available yet for this article.
July 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28685522/next-generation-post-evar-follow-up-regime
#10
REVIEW
Rita Soares Ferreira, Frederico Bastos Gonçalves
Durability of endovascular aneurysm repair is critical, since a significant proportion of patients suffer from procedure-related complications and secondary interventions after repair of abdominal aortic aneurysms. Therefore, regular follow up including imaging is recommended. The rationale behind current surveillance programs is to allow early detection and elective treatment of complications. However, current recommendations are laborious and resource consuming, may be deleterious to many patients and are largely inefficient...
December 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28611058/gnrhr-biallelic-and-digenic-mutations-in-patients-with-normosmic-congenital-hypogonadotropic-hypogonadism
#11
Catarina I Gonçalves, José M Aragüés, Margarida Bastos, Luísa Barros, Nuno Vicente, Davide Carvalho, Manuel C Lemos
OBJECTIVE: Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disorder characterised by lack of pubertal development and infertility, due to deficient production, secretion or action of gonadotropin-releasing hormone (GnRH) and, unlike Kallmann syndrome, is associated with a normal sense of smell. Mutations in the GNRHR gene cause autosomal recessive nCHH. The aim of this study was to determine the prevalence of GNRHR mutations in a group of 40 patients with nCHH. DESIGN: Cross-sectional study of 40 unrelated patients with nCHH...
August 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28595324/bacteriophage-use-to-control-salmonella-biofilm-on-surfaces-present-in-chicken-slaughterhouses
#12
Keila Carolina de Ornellas Dutka Garcia, Isadora Mainieri de Oliveira Corrêa, Larissa Quinto Pereira, Tarcísio Macedo Silva, Mateus de Souza Ribeiro Mioni, Ana Carolina de Moraes Izidoro, Igor Henrique Vellano Bastos, Guilherme Augusto Marietto Gonçalves, Adriano Sakai Okamoto, Raphael Lucio Andreatti Filho
Foodborne diseases represent a major risk to public health worldwide. Pathogenic bacteria can live in the form of biofilm within the food industry, providing a permanent source of contamination. The aim of this study was to evaluate the influence of the types of adhesion surfaces on Salmonella biofilm formation at eight different times, and analyze the action time of a bacteriophage pool on established biofilms. Most of the samples used were classified as weak biofilm producers, with serovars Enteritidis and Heidelberg showing the highest frequency of biofilm formation...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28579278/higher-30-day-mortality-in-patients-with-familial-abdominal-aortic-aneurysm-after-evar
#13
K M van de Luijtgaarden, F Bastos Gonçalves, S E Hoeks, J D Blankensteijn, D Böckler, R J Stolker, H J M Verhagen
OBJECTIVES: To determine the influence of a positive family history for aneurysms on clinical success and mortality after endovascular aneurysm repair (EVAR). METHODS: From 2009 to 2011, 1262 patients with abdominal aortic aneurysms (AAA) treated by EVAR were enrolled in a prospective, industry sponsored clinical registry ENGAGE. Patients were classified into familial and sporadic AAA patients according to baseline clinical reports. Clinical characteristics, aneurysm morphology, and follow-up were registered...
June 1, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28562699/sociodemographic-characteristics-of-indigenous-population-according-to-the-2000-and-2010-brazilian-demographic-censuses-a-comparative-approach
#14
COMPARATIVE STUDY
João Luiz Bastos, Ricardo Ventura Santos, Oswaldo Gonçalves Cruz, Luciene Aparecida Ferreira de Barros Longo, Leandro Okamoto da Silva
The sociodemographic profiles of different segments of the Brazilian population have been the object of multiple inter-census comparisons. This study compared the age distribution, number of household residents, formal schooling, and income of indigenous persons according to the population censuses of 2000 and 2010. There was an important decrease in the number of residents per occupied household, and slight aging of the indigenous population, except in the urban North. Meanwhile, there was a proportional increase in individuals with per capita household income up to one minimum wage, along with a reduction in the income bracket of more than two minimum wages in the country's five major geographic regions, in both urban and rural areas...
May 25, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28531839/genotoxic-and-mutagenic-effects-of-atrazine-atanor-50-sc-on-dendropsophus-minutus-peters-1872-anura-hylidae-developmental-larval-stages
#15
Macks Wendhell Gonçalves, Calebe Bertolino Marins de Campos, Vinícius Guerra Batista, Aparecido Divino da Cruz, Paulo de Marco Junior, Rogério Pereira Bastos, Daniela de Melo E Silva
The potential mutagenic and genotoxic effects of the herbicide atrazine were investigated in different developmental stages of Dendropsophus minutus tadpoles. These animals were exposed to 4 nominal concentrations of atrazine (2.25, 4.5, 9, and 18 mg/L) and 40 mg/L of Cyclophosphamide as a positive control, for 96 h. Negative controls were also added to the experiment. The tadpoles were divided into three groups according to Gosner's developmental stages, namely GS 25-33 as premetamorphic, GS 36-39 as prometamorphic, and GS 42-43 as metamorphic climax...
September 2017: Chemosphere
https://www.readbyqxmd.com/read/28444083/interictal-abnormal-fmri-activation-of-visual-areas-during-a-motor-task-cued-by-visual-stimuli-in-migraine
#16
Adriana Bastos Conforto, Khallil Taverna Chaim, Mario Fernando Prieto Peres, André Leite Gonçalves, Inara Laurindo Siqueira, Maria Angela Maramaldo Barreiros, Edson Amaro
Objective: To assess changes in blood-oxygen-level-dependent activity after light deprivation compared to regular light exposure in subjects with migraine in the interictal state and in controls. Methods: Ten subjects with migraine and ten controls participated in two sessions of functional magnetic resonance imaging. In each session, they performed a finger-tapping task with the right hand, cued by visual stimuli. They were scanned before and after 30 minutes of light deprivation or light exposure...
January 2017: Einstein
https://www.readbyqxmd.com/read/28403343/lycopene-and-resveratrol-pretreatment-did-not-interfere-with-the-liver-of-hepatectomized-rats
#17
Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes
Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28399226/biology-of-triatoma-sherlocki-hemiptera-reduviidae-under-laboratory-conditions-biological-cycle-and-resistance-to-starvation
#18
Vanessa Lima-Neiva, Teresa C M Gonçalves, Leonardo S Bastos, Marcia Gumiel, Nathália C Correia, Catia C Silva, Carlos E Almeida, Jane Costa
Triatoma sherlocki Papa, Jurberg, Carcavallo, Cerqueira & Barata was described in 2002, based on specimens caught in the wild in the municipality of Gentio do Ouro, Bahia, Brazil. In 2009, nymphs and adults were detected inside homes and sylvatic specimens were positive for Trypanosoma cruzi (Chagas). No information on the bionomics of T. sherlocki exists, although such data are considered essential to estimate its vector and colonization potential in domestic environments. Herein, the biological cycle of T...
July 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28388305/treatment-of-vascular-lesions-located-in-the-lip-and-in-the-oral-cavity-with-nd-yag-laser
#19
Julien Totti Bastos, Laila Klotz de Almeida Balassiano, Camila Roos Mariano da Rocha, Bruno Messias Pires de Freitas, Leonardo Gonçalves Bravo, Bruna Souza Felix Bravo
Vascular lesions such as hemangiomas can be found in the oral cavity. Some therapeutic modalities can be used in the treatment of these lesions and Nd:YAG 1064 nm long pulse laser shows good results with easy application, fewer complications and satisfactory results. This study describes the technique and outcome of a case of hemangioma located on the tongue treated with Nd:YAG laser.
April 7, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28359440/editor-s-choice-management-of-the-diseases-of-mesenteric-arteries-and-veins-clinical-practice-guidelines-of-the-european-society-of-vascular-surgery-esvs
#20
Writing Committee, M Björck, M Koelemay, S Acosta, F Bastos Goncalves, T Kölbel, J J Kolkman, T Lees, J H Lefevre, G Menyhei, G Oderich, Esvs Guidelines Committee, P Kolh, G J de Borst, N Chakfe, S Debus, R Hinchliffe, S Kakkos, I Koncar, J Sanddal Lindholt, M Vega de Ceniga, F Vermassen, F Verzini, Document Reviewers, B Geelkerken, P Gloviczki, T Huber, R Naylor
No abstract text is available yet for this article.
April 2017: European Journal of Vascular and Endovascular Surgery
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