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https://www.readbyqxmd.com/read/28328941/cynomolgus-monkeys-are-successfully-and-persistently-infected-with-hepatitis-e-virus-genotype-3-hev-3-after-long-term-immunosuppressive-therapy
#1
Noemi Rovaris Gardinali, Juliana Rodrigues Guimarães, Juliana Gil Melgaço, Yohan Britto Kevorkian, Fernanda de Oliveira Bottino, Yasmine Rangel Vieira, Aline Campos de Azevedo da Silva, Douglas Pereira Pinto, Laís Bastos da Fonseca, Leandro Schiavo Vilhena, Edilson Uiechi, Maria Cristina Carlan da Silva, Julio Moran, Renato Sérgio Marchevsky, Oswaldo Gonçalves Cruz, Rodrigo Alejandro Arellano Otonel, Amauri Alcindo Alfieri, Jaqueline Mendes de Oliveira, Ana Maria Coimbra Gaspar, Marcelo Alves Pinto
Epidemiological studies found that hepatitis E virus genotype 3 (HEV-3) infection was associated with chronic hepatitis and cirrhosis in immunocompromised patients. Our study aimed to investigate the relationship between the host immunosuppressive status and the occurrence of HEV-related chronic hepatitis. Here we describe a successful experimental study, using cynomolgus monkeys previously treated with tacrolimus, a potent calcineurin inhibitor immunosuppressant, and infected with a Brazilian HEV-3 strain isolated from naturally infected pigs...
2017: PloS One
https://www.readbyqxmd.com/read/28323038/monocular-denervation-of-visual-nuclei-modulates-app-processing-and-sapp%C3%AE-production-a-possible-role-on-neural-plasticity
#2
Juliana Ferreira Vasques, Pedro Vinícius Bastos Heringer, Renata Guedes de Jesus Gonçalves, Paula Campello-Costa, Claudio Alberto Serfaty, Adriana da Cunha Faria-Melibeu
Amyloid precursor protein (APP) is essential to physiological processes such as synapse formation and neural plasticity. Sequential proteolysis of APP by beta- and gamma-secretases generates amyloid-beta peptide (Aβ), the main component of senile plaques in Alzheimer Disease. Alternative APP cleavage by alpha-secretase occurs within Aβ domain, releasing soluble α-APP (sAPPα), a neurotrophic fragment. Among other functions, sAPPα is important to synaptogenesis, neural survival and axonal growth. APP and sAPPα levels are increased in models of neuroplasticity, which suggests an important role for APP and its metabolites, especially sAPPα, in the rearranging brain...
March 16, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28188320/effects-of-glyphosate-based-herbicide-sub-lethal-concentrations-on-fish-feeding-behavior
#3
Percilia Cardoso Giaquinto, Marina Borges de Sá, Vanessa Seiko Sugihara, Bruno Bastos Gonçalves, Helton Carlos Delício, Assaf Barki
Glyphosate-based herbicides are widely used in agricultural systems. Although the target organism are particularly plant organisms, there are numerous studies showing adverse effects in aquatic animals, such as inhibition of acetyl cholinesterase, effects on kidney, liver, and gill and stressors effects. This study analyzed the effects of commercial formulation of glyphosate on feeding behavior in Pacu (Piaractus mesopotamicus). Fish were exposed to three glyphosate concentrations (0.2, 0.6, and 1.8 ppm) for 15 days...
April 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28167160/comparative-study-of-the-cytotoxicity-and-genotoxicity-of-kaurenoic-acid-and-its-semi-synthetic-derivatives-methoxy-kaurenoic-acid-and-kaurenol-in-cho-k1-cells
#4
COMPARATIVE STUDY
Bruno Limonti Cano, Monique Rodrigues Moreira, Mirian Oliveira Goulart, Natália Dos Santos Gonçalves, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Raquel Alves Dos Santos
The diterpene kaurenoic acid (KA) has vasorelaxant, antimicrobial, anti-tumoural and anti-leishmanial effects. Semi-synthetic derivatives were obtained to achieve more satisfactory responses. The assessment of genotoxicity is part of the toxicological evaluation of therapeutic compound candidates. The present study investigated the cytotoxicity and genotoxicity of KA and its semi-synthetic derivatives methoxy kaurenoic acid (MKA) and kaurenol (KRN) using the CHO-K1 cell line. The cytotoxicity evaluation demonstrated that treatments with 200 and 400 μM KA reduced cellular proliferation to 36...
April 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28125123/-proposal-for-an-epidemiological-observatory-in-the-brazilian-unified-national-health-system
#5
Raphael de Freitas Saldanha, Ronaldo Rocha Bastos, Maria Teresa Bustamante-Teixeira, Isabel Cristina Gonçalves Leite, Estela Márcia Saraiva Campos
Following the creation of the Brazilian Unified National Health System (SUS), the Brazilian Health Informatics Department (DATASUS) was established in 1991, aimed at organizing information systems and databases in health. Online data access and viewing is free and open, using tables and graphs of aggregate data and access to raw data. However, the current form of data access does not fully meet the demands by health system administrators and other users for a flexible, user-friendly tool that allows dealing with various relevant health issues in the knowledge search and decision-making...
January 23, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28073666/standard-endovascular-aneurysm-repair-in-patients-with-wide-infrarenal-aneurysm-necks-is-associated-with-increased-risk-of-adverse-events
#6
Nelson F G Oliveira, Frederico M Bastos Gonçalves, Marie Josee Van Rijn, Quirina de Ruiter, Sanne Hoeks, Jean-Paul P M de Vries, Joost A van Herwaarden, Hence J M Verhagen
OBJECTIVE: Endovascular aneurysm repair (EVAR) has progressively expanded to treat more challenging anatomies. Although EVAR in patients with wide infrarenal necks has been reported with acceptable results, there is still controversy regarding the longer-term outcomes. Our aim is to determine the impact of infrarenal neck diameter on midterm outcome following EVAR with a single endograft with suprarenal fixation. METHODS: A retrospective case-control study was designed using data from a prospective multicenter database...
January 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28027890/iliac-seal-zone-dynamics-and-clinical-consequences-after-endovascular-aneurysm-repair
#7
F Bastos Gonçalves, N F Oliveira, M Josee van Rijn, K H J Ultee, S E Hoeks, S Ten Raa, R J Stolker, H J M Verhagen
OBJECTIVE: To evaluate the dynamics of the iliac attachment zone after EVAR, and the association with clinical events. METHODS: A tertiary institution's prospective EVAR database was searched to identify common iliac arteries at risk. Internally validated measurements were made, using centre lumen line reconstructions. Iliac dilatation and endograft limb retraction were the main endpoints. Associations between dilatation, retraction, oversizing, and distal seal length were investigated...
February 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27998049/long-term-results-of-outside-instructions-for-use-evar
#8
REVIEW
José Oliveira-Pinto, Nelson Oliveira, Frederico Bastos-Gonçalves, Sanne Hoeks, Marie Josee VAN Rijn, Sander Ten Raa, Armando Mansilha, Hence J Verhagen
INTRODUCTION: Endovascular aneurysm repair (EVAR) has progressively expanded to more complex anatomies, frequently outside manufacturer's instructions for use (IFU). However, the long term results of off-label use of EVAR remain largely undocumented. The aim of this paper is to examine the long term results of outside IFU EVAR. EVIDENCE ACQUISITION: English literature was searched to identify publications on long term results for outside IFU EVAR. A follow-up extending for at least 5 years was the minimum required as inclusion criteria...
April 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27931932/susceptibility-of-rhipicephalus-boophilus-microplus-to-fluazuron-2-5mg-kg-and-a-combination-of-novaluron-2-0mg-kg-eprinomectin-0-36mg-kg-in-field-studies-in-brazil
#9
Willian Giquelin Maciel, Welber Daniel Zanetti Lopes, Lucas Vinicius Costa Gomes, Breno Cayeiro Cruz, Gustavo Felippelli, Isabella Barbosa Dos Santos, Fernando de Almeida Borges, Walter Antonio Gonçalves, Alexandre Braga Scarpa, João Eduardo Nicaretta, Thiago Souza Azeredo Bastos, Alvimar José da Costa
The present study aimed to determine the susceptibility of 32 R. (B.) microplus populations from Southeast, Midwest and South regions of Brazil, to fluazuron (2.5mg/kg), administered topically (pour-on). Additionally, five populations (Southeast and Midwest regions) of the southern cattle tick were evaluated using in vivo field studies, regarding their susceptibility to a new combination of novaluron (2.0mg/kg)+eprinomectin (0.36mg/kg), administered subcutaneously, compared with two positive controls (fluazuron 2...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27916478/development-and-external-validation-of-a-model-predicting-death-after-surgery-in-patients-with-a-ruptured-abdominal-aortic-aneurysm-the-dutch-aneurysm-score
#10
G C I von Meijenfeldt, S C van Beek, F Bastos Gonçalves, H J M Verhagen, C J Zeebregts, A C Vahl, W Wisselink, M J van der Laan, R Balm
OBJECTIVE: The decision whether or not to proceed with surgical intervention of a patient with a ruptured abdominal aortic aneurysm (rAAA) is very difficult in daily practice. The primary objective of the present study was to develop and to externally validate a new prediction model: the Dutch Aneurysm Score (DAS). METHODS: With a prospective cohort of 10 hospitals (n = 508) the DAS was developed using a multivariate logistic regression model. Two retrospective cohorts with rAAA patients from two hospitals (n = 373) were used for external validation...
December 1, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27861686/-patient-satisfaction-evaluation-at-the-specialized-dental-centers-in-the-southeast-macro-region-of-minas-gerais-brazil-2013
#11
Elisa Shizuê Kitamura, Ronaldo Rocha Bastos, Pamella Valente Palma, Isabel Cristina Gonçalves Leite
METHODS: this was a cross-sectional study using the Oral Health Services Quality Assessment Questionnaire, with a probabilistic sample of 256 patients, using multiple linear regression to identify variables associated with their satisfaction. RESULTS: most patients stated they were satisfied (86.7%), followed by barely satisfied (10.2%) and very satisfied (3.1%); there were differences in satisfaction among patients attending the different SDCs; independent variables associated with patient satisfaction were 'improved self-perceived oral health' (p=0...
January 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27759835/vesicular-lesions-in-a-neonate-what-s-your-diagnosis
#12
Marta Sofia da Cunha Alves Machado, Elsa Cristina de Freitas Lima Teixeira, Lígia Maria Nogueira Ferreira, Lígia Raquel Gonçalves Basto
No abstract text is available yet for this article.
July 2016: Einstein
https://www.readbyqxmd.com/read/27759767/triatoma-maculata-colonises-urban-domicilies-in-boa-vista-roraima-brazil
#13
Alice Ricardo-Silva, Teresa Cristina Monte Gonçalves, José Francisco Luitgards-Moura, Catarina Macedo Lopes, Silvano Pedrosa da Silva, Amanda Queiroz Bastos, Nathalia Coelho Vargas, Maria-Rosa Goreti Freitas
During a medical entomology course in Boa Vista, Roraima, colonies of Triatoma maculata closely associated with pigeon nests were observed in concrete air-conditioner box located on the external plastered and cemented walls of a modern brick-built apartment block. In only one eight-hole ceramic brick, located inside one air-conditioner box, 127 specimens of T. maculata were collected. T. maculata is a recognised vector of Trypanosoma cruzi in the surrounding area and its domiciliation increases the risk of Chagas disease transmission...
November 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27624163/parental-awareness-and-perception-for-correct-use-of-child-restraint-systems-and-airbags-in-brazil
#14
Bruno Gonçalves Schröder E Souza, Tiago Evangelista de Melo, Tales Pereira Lisboa, Marcos Bastos Miranda, Thiago Gonçalves Schroder E Souza, Valdeci Manoel de Oliveira
OBJECTIVE: The objective of this study was to obtain information about the current knowledge and habits of parents who transport children in cars in Brazil. METHODS: A cross-sectional survey was conducted using specifically designed self-report questionnaires to parents of children attending a private pediatric office in a town in southwest Brazil. Data were collected regarding children's age, gender, height, and weight and possession of an automobile child restraint system (CRS), its type, frequency and adequacy of use, and reasons for not possessing or not using the devices...
February 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27589537/statistical-models-of-parkinson-s-disease-progression-predictive-validity-in-a-3-year-follow-up
#15
Alexandre Mendes, Alexandra Gonçalves, Nuno Vila-Chã, Margarida Calejo, Inês Moreira, Joana Fernandes, Joana Damásio, Armando Teixeira-Pinto, Paul Krack, António Bastos Lima, Sara Cavaco
BACKGROUND: The rate of Parkinson's disease (PD) progression varies widely between patients. Current knowledge does not allow to accurately predict the evolution of symptoms in a given individual over time. OBJECTIVES: To develop regression-based models of PD progression and to explore its predictive value in a three-year follow-up. METHODS: At baseline, 300 consecutive PD patients were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) - subscales II and III, Hoehn & Yahr (H&Y) and Schwab and England Independence Scale (S&E); and the Freezing of Gait Questionnaire (FOG-Q)...
October 19, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27588186/myelodysplastic-syndrome-without-ring-sideroblasts-and-with-janus-kinase-2-gene-mutation-an-unusual-case-report
#16
Maria Helena Ornellas, Monique De França Silva, Cristiana Solza, Stella Beatriz Sampaio De Lucena Gonçalves, Liliane Silva De Almeida, Jackline De Paula Ayres-Silva, Taís Leite Seixas, Elenice Ferreira Bastos, Thomas Liehr, Gilda Alves
Myelodysplastic syndrome (MDS) cases comprise a heterogeneous group of hematological disorders that are characterized by impaired hematopoiesis, with cytopenias of different grades and risk of developing acute myeloid leukemia. MDS may rarely be associated with thrombocytosis. In such cases, myelodysplasia and myeloproliferative disorders may overlap, making correct diagnosis difficult. We herein describe a case of MDS with thrombocytosis, Janus kinase 2 gene mutation-positive and Perls' staining-negative, which was initially classified as essential thrombocythemia (ET)...
September 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27579646/symptoms-in-smokers-with-preserved-pulmonary-function
#17
LETTER
Erno Harzheim, Marcelo R Gonçalves, Cynthia Molina-Bastos
No abstract text is available yet for this article.
September 1, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27544931/peripheral-artery-disease-patients-may-benefit-more-from-aggressive-secondary-prevention-than-aneurysm-patients-to-improve-survival
#18
Klaas H J Ultee, Sanne E Hoeks, Frederico Bastos Gonçalves, Eric Boersma, Robert Jan Stolker, Hence J M Verhagen, Ellen V Rouwet
BACKGROUND AND AIMS: Although it has become clear that aneurysmal and occlusive arterial disease represent two distinct etiologic entities, it is still unknown whether the two vascular pathologies are prognostically different. We aim to assess the long-term vital prognosis of patients with abdominal aortic aneurysmal disease (AAA) or peripheral artery disease (PAD), focusing on possible differences in survival, prognostic risk profiles and causes of death. METHODS: Patients undergoing elective surgery for isolated AAA or PAD between 2003 and 2011 were retrospectively included...
September 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27385153/challenging-anatomy-predicts-mortality-and-complications-after-endovascular-treatment-of-ruptured-abdominal-aortic-aneurysm
#19
Hassan Baderkhan, Frederico M Bastos Gonçalves, Nelson Gomes Oliveira, Hence J M Verhagen, Anders Wanhainen, Martin Björck, Kevin Mani
PURPOSE: To analyze the effects of aortic anatomy and endovascular aneurysm repair (EVAR) inside and outside the instructions for use (IFU) on outcomes in patients treated for ruptured abdominal aortic aneurysms (rAAA). METHODS: All 112 patients (mean age 73 years; 102 men) treated with standard EVAR for rAAA between 2000 and 2012 in 3 European centers were included in the retrospective analysis. Patients were grouped based on aortic anatomy and whether EVAR was performed inside or outside the IFU...
July 5, 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/27333137/-opportunistic-screening-versus-missed-opportunities-non-adherence-to-pap-smear-testing-in-women-attending-prenatal-care
#20
Luciane Ribeiro, Ronaldo Rocha Bastos, Marcel de Toledo Vieira, Luiz Cláudio Ribeiro, Maria Teresa Bustamante Teixeira, Isabel Cristina Gonçalves Leite
The objectives were to estimate the prevalence of non-adherence to Pap smear testing in women attending prenatal care and to identify associated factors. This was a cross-sectional population-based study in 308 women from a rural municipality (county) in Minas Gerais State, Brazil. Complex stratified cluster sampling was used. Statistical analysis used the chi-square test and logistic regression model with the variables that presented p-value ≤ 0.05 in the bivariate model. Prevalence of lack of Pap smear test was 21...
June 20, 2016: Cadernos de Saúde Pública
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