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https://www.readbyqxmd.com/read/27909989/orexin-and-central-modulation-of-cardiovascular-and-respiratory-function
#1
Pascal Carrive, Tomoyuki Kuwaki
Orexin makes an important contribution to the regulation of cardiorespiratory function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate, sympathetic nerve activity, and the amplitude and frequency of respiration. This is consistent with the location of orexin neurons in the hypothalamus and the distribution of orexin terminals at all levels of the central autonomic and respiratory network. These cardiorespiratory responses are components of arousal and are necessary to allow the expression of motivated behaviors...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27908788/time-to-wake-up-studying-neurovascular-coupling-and-brain-wide-circuit-function-in-the-un-anesthetized-animal
#2
REVIEW
Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T Winder, Zhifeng Liang, Lilith Antinori, Patrick J Drew, Nanyin Zhang
Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-based and resting-state brain dynamics in humans by inferring neural activity from blood-oxygenation-level dependent (BOLD) signal changes. An accurate interpretation of the hemodynamic changes that underlie fMRI signals depends on the understanding of the quantitative relationship between changes in neural activity and changes in cerebral blood flow, oxygenation and volume. While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function...
November 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27907934/restriction-of-postoperative-joint-loading-in-a-murine-model-of-anterior-cruciate-ligament-reconstruction-botulinum-toxin-paralysis-and-external-fixation
#3
Amir Lebaschi, Xiang-Hua Deng, Nathan W Coleman, Christopher L Camp, Jianchun Zong, Andrew Carbone, Camila B Carballo, Guang-Ting Cong, Zoe M Album, Scott A Rodeo
Control of knee motion in small animal models is necessary to study the effect of mechanical load on the healing process. This can be especially challenging in mice, which are being increasingly used for various orthopedic reconstruction models. We explored the feasibility of botulinum toxin (Botox; Allergan, Dublin, Ireland) paralysis and a newly designed external fixator to restrict motion of the knee in mice undergoing anterior cruciate ligament (ACL) reconstruction. Nineteen C57BL/6 mice were allocated to two groups: (1) Botox group (n = 9) and (2) external fixator group (n = 10)...
December 1, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27905668/subconjunctival-antimicrobial-poloxamer-gel-for-treatment-of-corneal-ulceration-in-stranded-california-sea-lions-zalophus-californianus
#4
Claire A Simeone, Carmen M H Colitz, Kathleen M Colegrove, Cara L Field, Carlos Rios, Heather L Chandler, Shawn P Johnson
OBJECTIVE: Corneal ulcers are commonly encountered in pinnipeds. Prolonged oral antibiotics and topical ophthalmic solutions may not be practical to administer, and novel treatment techniques are desired. Thermodynamic gels are a potential solution because they hold antimicrobials at the site of injection, slowly releasing drug. This study investigated the clinical efficacy of antibiotic-impregnated poloxamer gel in management of corneal ulceration. ANIMAL STUDIED: Twenty-six California sea lions undergoing rehabilitation at The Marine Mammal Center...
December 1, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27901396/effects-of-dobutamine-hydrochloride-on-cardiovascular-function-in-horses-anesthetized-with-isoflurane-with-or-without-acepromazine-maleate-premedication
#5
Mara F Schier, Anthea L Raisis, Cristy J Secombe, Giselle Hosgood, Gabrielle C Musk, Guy D Lester
OBJECTIVE To determine the effects of acepromazine maleate premedication on cardiovascular function before and after infusion of dobutamine hydrochloride for 30 minutes in isoflurane-anesthetized horses. ANIMALS 6 healthy adult horses. PROCEDURES Each horse was anesthetized once following premedication with acepromazine (0.02 mg/kg, IV) administered 30 minutes prior to anesthetic induction (ACP+ treatment) and once without premedication (ACP- treatment). Anesthesia was induced with IV administration of xylazine hydrochloride (0...
December 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27900774/paclitaxel-inhibits-post-traumatic-recurrent-laryngeal-nerve-regeneration-into-the-posterior-cricoarytenoid-muscle-in-a-canine-model
#6
Andrea M Park, Neel K Bhatt, Randal C Paniello
OBJECTIVES/HYPOTHESIS: To investigate the efficacy of paclitaxel, a potent microtubule inhibitor with a more favorable therapeutic index as compared with vincristine, in preventing post-traumatic nerve regeneration of the recurrent laryngeal nerve into the posterior cricoarytenoid muscle in a canine laryngeal model. STUDY DESIGN: Experimental animal study. METHODS: Forty-nine canine hemilaryngeal specimens were divided into five experimental groups...
November 30, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27899319/cost-effective-raspberry-pi-based-radio-frequency-identification-tagging-of-mice-suitable-for-automated-in-vivo-imaging
#7
Federico Bolaños, Jeff M LeDue, Timothy H Murphy
BACKGROUND: Automation of animal experimentation improves consistency, reduces potential for error while decreasing animal stress and increasing well-being. Radio frequency identification (RFID) tagging can identify individual mice in group housing environments enabling animal-specific tracking of physiological parameters. NEW METHOD: We describe a simple protocol to radio frequency identification (RFID) tag and detect mice. RFID tags were injected sub-cutaneously after brief isoflurane anesthesia and do not require surgical steps such as suturing or incisions...
November 26, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27891080/enhanced-burst-suppression-and-disruption-of-local-field-potential-synchrony-in-a-mouse-model-of-focal-cortical-dysplasia-exhibiting-spike-wave-seizures
#8
Anthony J Williams, Chen Zhou, Qian-Quan Sun
Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays were used to record extracellular potentials from cortical and subcortical brain regions near the FL in anesthetized mice (5-13 months old) followed by 24 h cortical electroencephalogram (EEG) recordings...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27884349/endotoxemia-accelerates-diaphragm-dysfunction-in-ventilated-rabbits
#9
Yi Yang, Tao Yu, Chun Pan, Federico Longhini, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu
BACKGROUND: Ventilators may induce diaphragm dysfunction, and most of the septic population who are admitted to the intensive care unit require mechanical ventilation. However, there is no evidence that sepsis accelerates the onset of ventilator-induced diaphragm dysfunction or affects the microcirculation. Our study investigated whether lipopolysaccharide (LPS)-induced endotoxemia accelerated diaphragm dysfunction in ventilated rabbits by evaluating microcirculation, lipid accumulation, and diaphragm contractility...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884326/appropriate-timing-of-blood-sampling-for-blood-gas-analysis-in-the-ventilated-rabbit
#10
Kiguna Sei, Masanori Fujita, Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Hidenori Sasa, Kenichi Furuya, Miya Ishihara
BACKGROUND: Arterial and venous blood gas analyses (BGAs) are essential to evaluate devices that measure biological oxygenation. The appropriate timing of blood sampling for BGA after respiratory rate (RR) change in animal experiments has not been reported. This study investigated the appropriate timing of blood sampling for BGA in ventilated rabbits and whether venous samples are an alternative to arterial samples. MATERIALS AND METHODS: Under general anesthesia, 14 rabbits (body weight, 3...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27882447/neonatal-repeated-exposure-to-isoflurane-not-sevoflurane-in-mice-reversibly-impaired-spatial-cognition-at-juvenile-age
#11
Jianhui Liu, Yanhong Zhao, Junjun Yang, Xiaoqing Zhang, Wei Zhang, Peijun Wang
Inhalation anesthetics facilitate surgical procedures in millions of children each year. However, animal studies demonstrate that exposure to the inhalation anesthetic isoflurane may cause neuronal cell death in developing brains. The long-term cytotoxic effects of sevoflurane, the most popular pediatric anesthetic, have not been compared with isoflurane. Thus, this study was designed to compare the effects of equipotent doses of these two anesthetics on neonatal long-term neurotoxicity. Postnatal 7-day-old (P7) C57/BL male mice were exposed to 1...
November 24, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27882081/effects-of-different-sutures-on-fibrosis-and-wound-healing-in-a-rabbit-model-of-corneal-wounds
#12
Ying Li, Hui J Chen, Hua Zhang, Jian G Wu, Yun T Hu, Zhi Z Ma
The aim of the study was to investigate wound healing and scar formation in rabbit corneal lamellar wounds repaired with simple interrupted sutures (SIS) or horizontal mattress sutures (HMS). Two parallel 'I'-shaped lamellar cornea wounds were created in one eye of 40 white New Zealand rabbits, while 5 uninjured rabbits were sacrificed to serve as normal controls. One side of the wounds, in the test rabbits, was closed with SIS, while the other side was treated with HMS. Ten days later, the stitches were removed under anesthesia...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27876652/isoflurane-exposure-leads-to-apoptosis-of-neurons-and-oligodendrocytes-in-20-and-40-day-old-rhesus-macaques
#13
Katie J Schenning, Kevin K Noguchi, Lauren Drew Martin, Francesca M Manzella, Omar H Cabrera, Gregory A Dissen, Ansgar M Brambrink
Previously we reported that a 5-hour exposure of 6-day-old (P6) rhesus macaques to isoflurane triggers robust neuron and oligodendrocyte apoptosis. In an attempt to further describe the window of vulnerability to anesthetic neurotoxicity, we exposed P20 and P40 rhesus macaques to 5h of isoflurane anesthesia or no exposure (control animals). Brains were collected 3h later and examined immunohistochemically to analyze neuronal and glial apoptosis. Brains exposed to isoflurane displayed neuron and oligodendrocyte apoptosis distributed throughout cortex and white matter, respectively...
November 19, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27875512/single-tooth-osteotomy-combined-wide-linear-corticotomy-under-local-anesthesia-for-correcting-anterior-protrusion-with-ectopically-erupted-canine
#14
Nur Serife Iskenderoglu, Byung-Joon Choi, Kyung Won Seo, Yeon-Ji Lee, Baek-Soo Lee, Seong-Hun Kim
BACKGROUNDS: This article presents the alternative surgical treatments of both anterior protrusion by carrying out retraction on mandibular anterior fragment, meanwhile applying retraction force on maxilla anterior teeth and ectopically erupted canine with using platelet-rich fibrin (PRF). METHODS: Anterior segmental osteotomy was combined with linear corticotomy under local anesthesia. The correction of right ectopic canine was achieved through 2 stages. First, dento-osseous osteotomy on palatal side was performed...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27870736/lidocaine-administration-controls-micrornas-alterations-observed-after-lung-ischemia-reperfusion-injury
#15
Lisa Rancan, Carlos Simón, Emmeline Marchal-Duval, Javier Casanova, Sergio Damian Paredes, Alberto Calvo, Cruz García, David Rincón, Agustín Turrero, Ignacio Garutti, Elena Vara
BACKGROUND: Ischemia-reperfusion injury (IRI) is associated with morbidity and mortality. MicroRNAs (miRNAs) have emerged as regulators of IRI, and they are involved in the pathogenesis of organ rejection. Lidocaine has proven anti-inflammatory activity in several tissues but its modulation of miRNAs has not been investigated. This work aims to investigate the involvement of miRNAs in lung IRI in a lung auto-transplantation model and to investigate the effect of lidocaine. METHODS: Three groups (sham, control, and Lidocaine), each comprising 6 pigs, underwent a lung autotransplantation...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27867470/effect-of-sevoflurane-anesthesia-on-the-comprehensive-mrna-expression-profile-of-the-mouse-hippocampus
#16
Tomo Hayase, Shunsuke Tachibana, Michiaki Yamakage
Postoperative nausea and vomiting (PONV) is a common complication after general anesthesia. Recent studies suggested that the hippocampus is involved in PONV. Hypothesising that hippocampal dopaminergic neurons are related to PONV, we examined the comprehensive mRNA profile of the hippocampus, using a sevoflurane-treated mouse model to confirm this. This study was conducted after approval from our institutional animal ethics committee, the Animal Research Center of Sapporo Medical University School of Medicine (project number: 12-033)...
April 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27866702/elucidation-of-percutaneously-accessible-lymph-nodes-in-swine-a-large-animal-model-for-interventional-lymphatic-research
#17
Dara Kraitchman, Ihab Kamel, Clifford Weiss, Christos Georgiades
PURPOSE: To define percutaneously accessible, anatomically reproducible swine lymph nodes using magnetic resonance imaging, ultrasound, and ethiodized oil (Lipiodol; Guerbet, Bloomington, Indiana) lymphangiography. MATERIALS AND METHODS: Five adult female swine (Yorkshire, 50-60 kg) were used. Under general anesthesia, T1-weighted and T2-weighted, coronal and axial images of the entire swine were obtained. The animal's extrathoracic, extraperitoneal soft tissues from the neck to the groins were examined with ultrasound...
November 17, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27861947/recurrent-laryngeal-nerve-regeneration-using-an-oriented-collagen-scaffold-containing-schwann-cells
#18
Shun-Ichi Chitose, Kiminori Sato, Mioko Fukahori, Shintaro Sueyoshi, Takashi Kurita, Hirohito Umeno
OBJECTIVES/HYPOTHESIS: Regeneration of the recurrent laryngeal nerve (RLN), which innervates the intrinsic laryngeal muscles such that they can perform complex functions, is particularly difficult to achieve. Synkinesis after RLN neogenesis leads to uncoordinated movement of laryngeal muscles. Recently, some basic research studies have used cultured Schwann cells (SCs) to repair peripheral nerve injuries. This study aimed to regenerate the RLN using an oriented collagen scaffold containing cultured SCs...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27858407/preclinical-imaging-anesthesia-in-rodents
#19
Giancarlo Vesce, Fabiana Micieli, Ludovica Chiavaccini
Despite the outstanding progress achieved by preclinical imaging science, laboratory animal anesthesia remains quite stationary. Ninety percent of preclinical imaging studies are carried on small rodents (mice and rats) anesthetized by outdated injectable and/or inhalation agents. A need for imaging awake (conscious) animals is questionably registered mainly for brain research, for phMRI and for accomplishing pain and analgesia studies. A need for improving current rodent anesthesia protocols and for enforcing the 3Rs paradigm is sought...
November 18, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27857736/anesthesia-induced-neurotoxicity-in-an-animal-model-of-the-developing-brain-mechanism-and-therapies
#20
Maiko Satomoto, Koshi Makita
No abstract text is available yet for this article.
September 2016: Neural Regeneration Research
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