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https://www.readbyqxmd.com/read/29341609/probing-and-quantifying-the-food-borne-pathogens-and-toxins-from-in-vitro-to-in-vivo
#1
Jing-Min Liu, Zhi-Hao Wang, Hui Ma, Shuo Wang
Development of real-time and in situ analytical methods for determination of food-borne pathogens and toxins ingested into human body would be a promising research direction in the food safety area. The present review starts with summarization of the up-to-date progress of the nanomaterial-assisted in vitro detection methods for pathogens and toxins, and finally focused on application of animal bioimaging to in vivo study, including prospective strategies for in vivo quantification of target pathogens or toxins and in vivo investigation of their behaviors inside the living body, with the assistance of real-time and non-invasive optical bioimaging...
January 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29341109/the-prescribable-drugs-with-efficacy-in-experimental-epilepsies-pde3-database-for-drug-repurposing-research-in-epilepsy
#2
Shayeeshan Sivapalarajah, Mathangi Krishnakumar, Harry Bickerstaffe, YikYing Chan, Joseph Clarkson, Alistair Hampden-Martin, Ahmad Mirza, Matthew Tanti, Anthony Marson, Munir Pirmohamed, Nasir Mirza
OBJECTIVE: Current antiepileptic drugs (AEDs) have several shortcomings. For example, they fail to control seizures in 30% of patients. Hence, there is a need to identify new AEDs. Drug repurposing is the discovery of new indications for approved drugs. This drug "recycling" offers the potential of significant savings in the time and cost of drug development. Many drugs licensed for other indications exhibit antiepileptic efficacy in animal models. Our aim was to create a database of "prescribable" drugs, approved for other conditions, with published evidence of efficacy in animal models of epilepsy, and to collate data that would assist in choosing the most promising candidates for drug repurposing...
January 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29337618/vegetative-valvular-endocarditis-and-hepatitis-associated-with-helcococcus-ovis-in-a-7-year-old-white-leghorn-rooster
#3
Manuela Crispo, Simone Stoute, Thaiza Savaris, Arthur Bickford, Tiffany Santoro, C Gabriel Sentíes-Cué
Helcococcus ovis is a slow-growing, pyridoxal-dependent, Gram-positive coccus belonging to the Peptostreptococcaceae family. Bacteria belonging to the genus Helcococcus are considered normal inhabitants of keratinized epithelium in humans; however, several reports support their role as pathogens in humans and several animal species. This case report describes the identification of H. ovis in a white leghorn rooster with valvular vegetative endocarditis and hepatitis. In February 2017 one dead, 7-yr-old, white leghorn rooster was submitted to the California Animal Health and Food Safety Turlock laboratory for diagnostic testing...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29334188/soft-artificial-bladder-detrusor
#4
Xuxu Yang, Chengrui An, Shuting Liu, Tingyu Cheng, Varitsara Bunpetch, Yixiao Liu, Shurong Dong, Shijian Li, Xiaohui Zou, Tiefeng Li, Hongwei Ouyang, Zhaohui Wu, Wei Yang
Developing soft devices for invasive procedures bears great importance for human health. The softness and large strain actuation of responsive hydrogels promise the potential to fabricate soft devices, which can attach on and assist to the function of organs. The key challenges lie in the fabrication of soft devices with robust actuating ability and biocompatibility to the attached organ. This paper presents a solution that integrates the thermoresponsive hydrogel membrane with flexible electronics and silk scaffold into a balloon-like soft device...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29333863/principles-of-vaccine-potency-assays
#5
Thorsten Verch, Jeremiah J Trausch, Mary Shank-Retzlaff
Compared with biologics, vaccine potency assays represent a special challenge due to their unique compositions, multivalency, long life cycles and global distribution. Historically, vaccines were released using in vivo potency assays requiring immunization of dozens of animals. Modern vaccines use a variety of newer analytical tools including biochemical, cell-based and immunochemical methods to measure potency. The choice of analytics largely depends on the mechanism of action and ability to ensure lot-to-lot consistency...
January 15, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29333553/microwave-assisted-synthesis-of-tempo-labeled-hydrogels-traceable-with-mri
#6
Emanuele Mauri, Edoardo Micotti, Arianna Rossetti, Lucio Melone, Simonetta Papa, Giulia Azzolini, Stefano Rimondo, Pietro Veglianese, Carlo Punta, Filippo Rossi, Alessandro Sacchetti
Polymer functionalization strategies have recently attracted considerable attention for several applications in biomaterials science. In particular, technological advancements in medical imaging have focused on the design of polymeric matrices to improve non-invasive approaches and diagnostic accuracy. In this scenario, the use of microwave irradiation of aqueous solutions containing appropriate combinations of polymers is gaining increasing interest in the synthesis of sterile hydrogels without using monomers, eliminating the need to remove unreacted species...
January 15, 2018: Soft Matter
https://www.readbyqxmd.com/read/29324568/effects-of-pressure-support-ventilation-on-ventilator-induced-lung-injury-in-mild-acute-respiratory-distress-syndrome-depend-on-level-of-positive-end-expiratory-pressure
#7
Paulo A F Magalhães, Gisele de A Padilha, Lillian Moraes, Cíntia L Santos, Ligia de A Maia, Cassia L Braga, Maria do Carmo M B Duarte, Lívia B Andrade, Alberto Schanaider, Vera L Capellozzi, Robert Huhle, Marcelo Gama de Abreu, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva
BACKGROUND: Harmful effects of spontaneous breathing have been shown in experimental severe acute respiratory distress syndrome (ARDS). However, in the clinical setting, spontaneous respiration has been indicated only in mild ARDS. To date, no study has compared the effects of spontaneous assisted breathing with those of fully controlled mechanical ventilation at different levels of positive end-expiratory pressure (PEEP) on lung injury in ARDS. OBJECTIVE: To compare the effects of assisted pressure support ventilation (PSV) with pressure-controlled ventilation (PCV) on lung function, histology and biological markers at two different PEEP levels in mild ARDS in rats...
January 10, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29324511/evolutionary-improvements-in-the-jarvik-2000-left-ventricular-assist-device
#8
Craig H Selzman, Antigone Koliopoulou, Jason P Glotzbach, Stephen H McKellar
Mechanical circulatory support devices experience a wide range of operating conditions during patient use. Since its first implant in June 2000, the Jarvik 2000 left ventricular assist device has witnessed systematic stepwise modifications to reduce the risk of serious adverse events and improve patient outcomes. Over time, clinical experience revealed a number of low-incidence failure modes that presented opportunities for improvement. Design changes have included, but are not limited to, a Y cable to permit battery changes without pump stoppage, increased pull strength of external cables from 35 to 200 lbs, an intermittent low-speed controller to improve aortic root washout, sintered titanium microsphere surface on the pump housing to prevent apical thrombus, and novel cone bearings to reduce thrombus formation...
January 10, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29320728/in%C3%A2-vivo-function-of-the-chaperonin-tric-in-%C3%AE-actin-folding-during-sarcomere-assembly
#9
Joachim Berger, Silke Berger, Mei Li, Arie S Jacoby, Anders Arner, Navid Bavi, Alastair G Stewart, Peter D Currie
The TCP-1 ring complex (TRiC) is a multi-subunit group II chaperonin that assists nascent or misfolded proteins to attain their native conformation in an ATP-dependent manner. Functional studies in yeast have suggested that TRiC is an essential and generalized component of the protein-folding machinery of eukaryotic cells. However, TRiC's involvement in specific cellular processes within multicellular organisms is largely unknown because little validation of TRiC function exists in animals. Our in vivo analysis reveals a surprisingly specific role of TRiC in the biogenesis of skeletal muscle α-actin during sarcomere assembly in myofibers...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29313705/harmonisation-of-animal-testing-alternatives-in-china
#10
REVIEW
Shujun Cheng, Xiaoting Qu, Yao Qin
More and more countries are lining up to follow the EU's approach and implement a full ban on the sale of cosmetics that have been tested on animals, which has been the case in the EU since 2013. Besides animal welfare considerations, the need for mutual acceptance of data (MAD) and harmonisation of the global market have made the move toward non-animal testing a desirable general trend for countries worldwide. Over the last 10 years, the concept of alternative methods has been gradually developing in China...
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29310555/mechanical-circulatory-support-for-the-failing-fontan-conversion-to-assisted-single-ventricle-circulation-preliminary-observations
#11
Syed M Peer, Kristopher B Deatrick, Thomas J Johnson, Jonathan W Haft, Francis D Pagani, Richard G Ohye, Edward L Bove, Alvaro Rojas-Peña, Ming-Sing Si
BACKGROUND: Mechanical circulatory support (MCS) of a failing Fontan circulation remains challenging. We hypothesized that MCS can be provided by converting the Fontan circulation into a mechanically assisted single ventricle parallel circulation (MASVC). METHODS: A porcine model of functionally univentricular circulation was created under cardiopulmonary bypass (CPB) by performing an atrial septectomy, tricuspid valvectomy, and interrupting antegrade pulmonary blood flow...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29306441/liposome-assisted-metabolic-glycan-labeling-with-cell-and-tissue-selectivity
#12
Yifei Du, Ran Xie, Yuting Sun, Xinqi Fan, Xing Chen
Metabolic labeling of glycans with sugar chemical reporters (i.e., unnatural sugars bearing a bioorthogonal group), followed by bioorthogonal reaction with imaging probes or affinity tags, has enabled visualization and proteomic analysis of glycosylation in live cells and in living animals. This two-step metabolic glycan labeling strategy has emerged as a powerful tool for probing glycosylation, but suffers from a lack of cell-type selectivity. Here we describe liposome-assisted bioorthogonal reporter (LABOR), a liposome-assisted format of metabolic glycan labeling that allows for cell-selective and tissue-specific glycan imaging and glycoproteomic profiling...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29305735/anglenav-mems-tracker-to-facilitate-ct-guided-puncture
#13
Rui Li, Sheng Xu, William F Pritchard, John W Karanian, Venkatesh P Krishnasamy, Bradford J Wood, Zion Tsz Ho Tse
As a low-cost needle navigation system, AngleNav may be used to improve the accuracy, speed, and ease of CT-guided needle punctures. The AngleNav hardware includes a wireless device with a microelectromechanical (MEMS) tracker that can be attached to any standard needle. The physician defines the target, desired needle path and skin entry point on a CT slice image. The accuracy of AngleNav was first tested in a 3D-printed calibration platform in a benchtop setting. An abdominal phantom study was then performed in a CT scanner to validate the accuracy of the device's angular measurement...
January 5, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29305535/an-insula-central-amygdala-circuit-for-guiding-tastant-reinforced-choice-behavior
#14
Hillary Schiff, Anna Lien Bouhuis, Kai Yu, Mario A Penzo, Haohong Li, Miao He, Bo Li
Predicting which substances are suitable for consumption during foraging is critical for animals to survive. Despite extensive study, the neural circuit mechanisms underlying such adaptive behavior remain poorly understood. Here we examined the anatomical and functional connectivity of the insular cortex (IC) to central amygdala (CeA) circuit and the role of this circuit in the establishment of appropriate behavioral responses in a tastant (sucrose/quinine)-reinforced "go/no-go" task in male and female mice...
January 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29304077/ideal-parameters-for-femto-second-laser-assisted-anterior-capsulotomy-animal-studies
#15
Min-Ji Kang, Yong-Eun Lee, Jun-Sub Choi, Choun-Ki Joo
In femtosecond laser-assisted cataract surgery, the parameter such as horizontal spot spacing and energy level can be adjusted. Although there have been several studies reported on various laser systems, showing the effects of varying energy levels and horizontal spot spacing on lens capsulotomy cut edges, none have been reported on the Catalys laser system (Abbott Medical Optics, Inc., Santa Ana, CA). The aim of this study is to evaluate, using scanning electron microscopy (SEM), the quality of the cut edges of the laser lens capsulotomy obtained using the Catalys Laser System, using different horizontal spot spacing and energy levels, and to determine the ideal parameters based on SEM results...
2018: PloS One
https://www.readbyqxmd.com/read/29299496/effects-of-human-adipose-derived-stem-cells-and-platelet-rich-plasma-on-healing-response-of-canine-alveolar-surgical-bone-defects
#16
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Background: Due to the known disadvantages of autologous bone grafting, tissue engineering approaches have become an attractive method for ridge augmentation in dentistry. To the best of our knowledge, this is the first study conducted to evaluate the potential therapeutic capacity of PRP-assisted hADSCs seeded on HA/TCP granules on regenerative healing response of canine alveolar surgical bone defects. This could offer a great advantage to alternative approaches of bone tissue healing-induced therapies at clinically chair-side procedures...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29298608/resorbable-self-locking-implant-for-lung-lobectomy-through-video-assisted-thoracoscopic-surgery-first-live-animal-application
#17
Rogério Luizari Guedes, Odd Viking Höglund, Juliana Sperotto Brum, Niklas Borg, Peterson Triches Dornbusch
The aim of this pilot test was to test a new self-locking resorbable implant for hilum occlusion during a video-assisted thoracoscopic lung lobectomy in a surviving pig model. Once the thoracic cavity was assessed and structures identified, the right middle lobe and its respective hilum were exposed. The implant was introduced with a semiclosed loop through a working channel and positioned around the pulmonary lobe. Occlusion was performed with a conventional Crile forceps and a laparoscopic Kelly forceps. Lobe section was done with laparoscopic Metzenbaum scissors and tissue removal through the dorsal access...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29297855/animal-assisted-intervention-aai-for-children-in-either-research-practice-or-policy-from-a-one-health-perspective-editorial
#18
Federica Pirrone
No abstract text is available yet for this article.
October 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29297598/visualization-of-the-distribution-of-anthocyanin-species-in-mice-eyeball-by-maldi-mass-spectrometry-imaging
#19
Shuhei Yamada, Nobuhiro Zaima, Yukihiro Yoshimura, Shiori Inaba, Takamichi Fujimori, Tetsuya Sogon, Tatsuya Moriyama
RATIONALE: Anthocyanins, which belong to a class of molecules called flavonoids, are known to have beneficial effects for both humans and animals. Many physiological functions have been attributed to anthocyanins since ancient times. The most important function is the relief of eyestrain, but the biodistribution of anthocyanins remains unknown. In this study, we analyzed the kinetics of anthocyanin species in mice eyeballs and surrounding tissues. METHODS: We used mice that were administered bilberry extract solution intraperitoneally...
January 3, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29289782/applying-acoustic-telemetry-to-understand-contaminant-exposure-and-bioaccumulation-patterns-in-mobile-fishes
#20
Matthew D Taylor, Dylan E van der Meulen, Stephanie Brodie, Gwenaël Cadiou, Nathan A Knott
Contamination in urbanised estuaries presents a risk to human health, and to the viability of populations of exploited species. Assessing animal movements in relation to contaminated areas may help to explain patterns in bioaccumulation, and assist in the effective management of health risks associated with consumption of exploited species. Using polychlorinated dibenzodioxin and polychlorinated dibenzofuran (PCDD/Fs) contamination in Sydney Harbour estuary as a case study, we present a study that links movement patterns resolved using acoustic telemetry to the accumulation of contaminants in mobile fish on a multi-species basis...
December 28, 2017: Science of the Total Environment
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