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https://www.readbyqxmd.com/read/29050399/diagnostic-criteria-for-chronic-lymphocytic-inflammation-with-pontine-perivascular-enhancement-responsive-to-steroids-clippers
#1
W Oliver Tobin, Yong Guo, Karl N Krecke, Joseph E Parisi, Claudia F Lucchinetti, Sean J Pittock, Jay Mandrekar, Divyanshu Dubey, Jan Debruyne, B Mark Keegan
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a central nervous system inflammatory syndrome predominantly affecting the brainstem, cerebellum, and spinal cord. Following its initial description, the salient features of CLIPPERS have been confirmed and expanded upon, but the lack of formalized diagnostic criteria has led to reports of patients with dissimilar features purported to have CLIPPERS. We evaluated clinical, radiological and pathological features of patients referred for suspected CLIPPERS and propose diagnostic criteria to discriminate CLIPPERS from non-CLIPPERS aetiologies...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29049608/acute-administration-of-oestradiol-or-progesterone-in-a-spinal-cord-ischaemia-reperfusion-model-in-rats
#2
Leonardo Pessoa Cavalcante, Sueli Gomes Ferreira, Daniel Romano Pereira, Sergio Rodrigues de Moraes, Rafael Simas, Paulina Sannomiya, Ana Cristina Breithaupt-Faloppa, Luiz Felipe Pinho Moreira
OBJECTIVES: Despite research into protective pharmacological adjuncts, paraplegia persists as a dreaded complication after thoracic and thoracoabdominal aortic interventions. Reports on gender-related neurological outcomes after ischaemic and traumatic brain injuries have led to increased interest in hormonal neuroprotective effects and have generated other studies seeking to prove the neuroprotective effects of the therapeutic administration of 17β-oestradiol and of progesterone. We hypothesised that acute administration of oestradiol or progesterone would prevent or attenuate spinal cord ischaemic injury induced by occlusion of the descending thoracic aorta...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049326/a-new-machine-learning-method-to-prognosticate-paraquat-poisoned-patients-by-combining-coagulation-liver-and-kidney-indices
#3
Lufeng Hu, Huaizhong Li, Zhennao Cai, Feiyan Lin, Guangliang Hong, Huiling Chen, Zhongqiu Lu
The prognosis of paraquat (PQ) poisoning is highly correlated to plasma PQ concentration, which has been identified as the most important index in PQ poisoning. This study investigated the predictive value of coagulation, liver, and kidney indices in prognosticating PQ-poisoning patients, when aligned with plasma PQ concentrations. Coagulation, liver, and kidney indices were first analyzed by variance analysis, receiver operating characteristic curves, and Fisher discriminant analysis. Then, a new, intelligent, machine learning-based system was established to effectively provide prognostic analysis of PQ-poisoning patients based on a combination of the aforementioned indices...
2017: PloS One
https://www.readbyqxmd.com/read/29048791/-an-improvement-of-the-calibration-results-for-grey-analytical-system-in-high-performance-liquid-chromatography-applying-constrained-background-bilinearization-method-based-on-genetic-algorithm-optimization-strategy
#4
Yaxiong Zhang, Xianling Nie
Constrained background bilinearization (CBBL) method was applied for multivariate calibration analysis of the grey analytical system in high performance liquid chromatography (HPLC). By including the variables of the concentrations and the retention time of the analytes simultaneously, the standard CBBL was modified for the multivariate calibration of the HPLC system with poor retention precision. The CBBL was optimized globally by genetic algorithm (GA). That is to say, both the concentrations and the retention times of the analytes were optimized globally and simultaneously by GA...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048397/correlation-analysis-of-pm10-and-the-incidence-of-lung-cancer-in-nanchang-china
#5
Yi Zhou, Lianshui Li, Lei Hu
Air pollution and lung cancer are closely related. In 2013, the World Health Organization listed outdoor air pollution as carcinogenic and regarded it as the most widespread carcinogen that humans are currently exposed to. Here, grey correlation and data envelopment analysis methods are used to determine the pollution factors causing lung cancer among residents in Nanchang, China, and identify population segments which are more susceptible to air pollution. This study shows that particulate matter with particle sizes below 10 micron (PM10) is most closely related to the incidence of lung cancer among air pollution factors including annual mean concentrations of SO₂, NO₂, PM10, annual haze days, and annual mean Air Pollution Index/Air Quality Index (API/AQI)...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29047382/a-novel-and-fully-automated-mammographic-texture-analysis-for-risk-prediction-results-from-two-case-control-studies
#6
Chao Wang, Adam R Brentnall, Jack Cuzick, Elaine F Harkness, D Gareth Evans, Susan Astley
BACKGROUND: The percentage of mammographic dense tissue (PD) is an important risk factor for breast cancer, and there is some evidence that texture features may further improve predictive ability. However, relatively little work has assessed or validated textural feature algorithms using raw full field digital mammograms (FFDM). METHOD: A case-control study nested within a screening cohort (age 46-73 years) from Manchester UK was used to develop a texture feature risk score (264 cases diagnosed at the same time as mammogram of the contralateral breast, 787 controls) using the least absolute shrinkage and selection operator (LASSO) method for 112 features, and validated in a second case-control study from the same cohort but with cases diagnosed after the index mammogram (317 cases, 931 controls)...
October 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29045807/evidence-reversal-when-new-evidence-contradicts-current-claims-a-systematic-overview-review
#7
REVIEW
Desirée Sutton, Riaz Qureshi, Janet Martin
OBJECTIVE: To explore the terminology and definitions surrounding the phenomenon of Evidence Reversal - which occurs when an existing claim is tested and the original evidence is contradicted by new and stronger evidence. STUDY DESIGN AND SETTING: For this overview systematic review, multiple medical and grey literature databases were systematically searched from inception to 2016 as well as hand searches of relevant journals, websites, blogs, article bibliographies, citing articles, and related articles...
October 15, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29045561/structural-variability-across-the-primate-brain-a-cross-species-comparison
#8
Paula L Croxson, Stephanie J Forkel, Leonardo Cerliani, Michel Thiebaut de Schotten
A large amount of variability exists across human brains; revealed initially on a small scale by postmortem studies and, more recently, on a larger scale with the advent of neuroimaging. Here we compared structural variability between human and macaque monkey brains using grey and white matter magnetic resonance imaging measures. The monkey brain was overall structurally as variable as the human brain, but variability had a distinct distribution pattern, with some key areas showing high variability. We also report the first evidence of a relationship between anatomical variability and evolutionary expansion in the primate brain...
October 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29044981/use-of-biocontrol-agents-and-botanicals-in-integrated-management-of-botrytis-cinerea-in-table-grape-vineyards
#9
Caterina Rotolo, Rita M De Miccolis Angelini, Crescenza Dongiovanni, Stefania Pollastro, Giulio Fumarola, Michele Di Carolo, Donato Perrelli, Patrizia Natale, Francesco Faretra
BACKGROUND: The increasing interest on biological control agents (BCAs) and botanicals (BOTs) is due to the increasing awareness on environmental and human health risks associated to the usage of synthetic plant protection products. The BCAs Bacillus subtilis strain QST713, Bacillus amyloliquefaciens strain D747 and Aureobasidium pullulans strains DSM14940 and DSM14941, and the BOTs Melaleuca alternifolia and terpenic extracts are proposed for the control of grey mould in vineyard. This study was aimed at evaluating their effectiveness in integrated crop management strategies and their outcomes in terms of management of fungicide resistance and residues...
October 17, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29044134/impact-of-ocean-warming-on-sustainable-fisheries-management-informs-the-ecosystem-approach-to-fisheries
#10
N Serpetti, A R Baudron, M T Burrows, B L Payne, P Helaouët, P G Fernandes, J J Heymans
An integrated ecosystem model including fishing and the impact of rising temperatures, relative to species' thermal ranges, was used to assess the cumulative effect of future climate change and sustainable levels of fishing pressure on selected target species. Historically, important stocks of cod and whiting showed declining trends caused by high fisheries exploitation and strong top-down control by their main predators (grey seals and saithe). In a no-change climate scenario these stocks recovered under sustainable management scenarios due to the cumulative effect of reduced fishing and predation mortalities cascading through the food-web...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043826/abo-serology-in-a-case-of-persistent-weak-a-in-a-recipient-following-a-group-o-matched-unrelated-bone-marrow-transplant
#11
Dianne E Grey, Elizabeth A Fong, Catherine Cole, Jesper Jensen, Jill Finlayson
HLA-matched hematopoietic stem cell transplantation (HSCT) from red blood cell (RBC)-incompatible donors is not uncommon. The engraftment process following ABO-incompatible allogeneic HSCT results in the transition from patient blood group to donor blood group in the recipient. In contrast, most non-hematopoietic tissues retain expression of the patient's original blood group for life, and these antigens may adsorb from the plasma onto the donor-derived RBCs. Correct serologic interpretation of the ABO blood group during this engraftment process can be difficult...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29042375/non-invasive-brain-stimulation-interventions-for-management-of-chronic-central-neuropathic-pain-a-scoping-review-protocol
#12
Mei Lin Chen, Lin Yao, Jennifer Boger, Kathryn Mercer, Benjamin Thompson, Ning Jiang
INTRODUCTION: Pain can affect people regardless of age, gender or ethnicity. Chronic central neuropathic pain (CCNP) is a debilitating condition that affects populations such as stroke survivors, amputees, spinal cord injury patients and patients with multiple sclerosis, with prevalence rates between 30% and 80%. This condition can be caused by a lesion or disease affecting the somatosensory system. CCNP is notoriously drug resistant, and few effective CCNP treatment or management strategies exist...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29041451/experimental-demonstration-of-optical-interconnects-exploiting-orbital-angular-momentum-array
#13
Shuhui Li, Jian Wang
To improve the transmission capacity and integration level of future optical interconnect systems, we present a communication scheme using orbital angular momentum (OAM) array encoding/decoding. By optimizing the use of space dimension (spatially orthogonal modes and spatial positions), information carried by a single symbol can be greatly improved. Experiment demonstration of 625-element and 1296-element high-base OAM array encoding/decoding by employing an array with 4 spatial locations each with 5 and 6 possible OAM beams are presented...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29040516/integrated-mental-health-services-in-china-challenges-and-planning-for-the-future
#14
Di Liang, Vickie M Mays, Wei-Chin Hwang
Eager to build an integrated community-based mental health system, in 2004 China started the '686 Programme', whose purpose was to integrate hospital and community services for patients with serious mental illness. In 2015, the National Mental Health Working Plan (2015-2020) proposed an ambitious strategy for implementing this project. The goal of this review is to assess potential opportunities for and barriers to successful implementation of a community-based mental health system that integrates hospital and community mental health services into the general healthcare system...
October 13, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29037083/cervical-cancer-histology-image-identification-method-based-on-texture-and-lesion-area-features
#15
Lisheng Wei, Quan Gan, Tao Ji
The issue of an automated approach for detecting cervical cancer is proposed to improve the accuracy of recognition. Firstly, the cervical cancer histology source images are needed to use image preprocessing for reducing the impact brought by noise of images as well as the impact on subsequent precise feature extraction brought by irrelevant background. Secondly, the images are grouped into ten vertical images and the information of texture feature is extracted by Grey Level Co-occurrence Matrix (GLCM). GLCM is an effective tool to analyze the features of texture...
October 16, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29036794/assessing-the-effect-of-different-operation-techniques-on-postoperative-duplex-ultrasound-quality-after-carotid-endarterectomy
#16
E Grambow, T Heller, P Wieneke, C Weiß, E Klar, M Weinrich
BACKGROUND: Duplex ultrasound is the first choice in diagnostics and surveillance of stenoses of the internal carotid arteries before and even after surgery. Therefore, the quality of duplex ultrasound is crucial to investigate these vascular pathologies. OBJECTIVE: Aim of this study was the evaluation whether different surgical techniques affect the postoperative quality of duplex ultrasound. METHODS: In a time period from January to May 2015 duplex ultrasound of the cervical vessels was performed in 75 patients after unilateral endarterectomy of the internal carotid artery at our department between 2006 and 2012...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29036689/high-dose-fast-neutron-dosimetry-using-padc-plastic-nuclear-track-detectors-and-grey-level-analysis
#17
A Stabilini, K Meier, E G Yukihara
The objective of this work is to demonstrate the possibility of performing fast neutron dosimetry up to 5 Sv using optical absorbance of polyallyl diglycol carbonate (PADC) detectors, obtained through grey level analysis of PADC images acquired with a commercial track-counting dosimetry system, and estimate the uncertainties involved. PADCs were irradiated with doses from 100 mSv to 5 Sv (252Cf source) and etched. PADC images were acquired using the TASLIMAGE™ Neutron Dosimetry System (Track Analysis Systems Ltd...
September 28, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29035166/strengthening-expertise-for-health-technology-assessment-and-priority-setting-in-africa
#18
Jane E Doherty, Thomas Wilkinson, Ijeoma Edoka, Karen Hofman
BACKGROUND: Achieving sustainable universal health coverage depends partly on fair priority-setting processes that ensure countries spend scarce resources wisely. While general health economics capacity-strengthening initiatives exist in Africa, less attention has been paid to developing the capacity of individuals, institutions and networks to apply economic evaluation in support of health technology assessment and effective priority-setting. OBJECTIVE: On the basis of international  lessons, to identify how research organisations and partnerships could contribute to capacity strengthening for health technology assessment and priority-setting in Africa...
2017: Global Health Action
https://www.readbyqxmd.com/read/29034479/scaling-of-the-ankle-extensor-muscle-tendon-units-and-the-biomechanical-implications-for-bipedal-hopping-locomotion-in-the-post-pouch-kangaroo-macropus-fuliginosus
#19
Edward P Snelling, Andrew A Biewener, Qiaohui Hu, David A Taggart, Andrea Fuller, Duncan Mitchell, Shane K Maloney, Roger S Seymour
Bipedal hopping is used by macropods, including rat-kangaroos, wallabies and kangaroos (superfamily Macropodoidea). Interspecific scaling of the ankle extensor muscle-tendon units in the lower hindlimbs of these hopping bipeds shows that peak tendon stress increases disproportionately with body size. Consequently, large kangaroos store and recover more strain energy in their tendons, making hopping more efficient, but their tendons are at greater risk of rupture. This is the first intraspecific scaling analysis on the functional morphology of the ankle extensor muscle-tendon units (gastrocnemius, plantaris and flexor digitorum longus) in one of the largest extant species of hopping mammal, the western grey kangaroo Macropus fuliginosus (5...
October 16, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29034075/structural-brain-abnormalities-in-12-persons-with-aniridia
#20
Madison K Grant, Anastasia M Bobilev, Jordan E Pierce, Jon DeWitte, James D Lauderdale
Background: Aniridia is a disorder predominately caused by heterozygous loss-of-function mutations of the PAX6 gene, which is a transcriptional regulator necessary for normal eye and brain development.  The ocular abnormalities of aniridia have been well characterized, but mounting evidence has implicated brain-related phenotypes as a prominent feature of this disorder as well.  Investigations using neuroimaging in aniridia patients have shown reductions in discrete brain structures and changes in global grey and white matter...
2017: F1000Research
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