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https://www.readbyqxmd.com/read/29916225/effect-of-cineole-alpha-pinene-and-camphor-on-survivability-of-skin-flaps
#1
Bilsev İnce, Mehmet Dadacı, İbrahim Kılınç, Pembe Oltulu, Serhat Yarar, Mehmet Uyar
Background/aim: The aim of this study was to determine the specific component of Rosmarinus officinalis (RO) responsible for increased flap survival and how RO displays its efficacy. Materials and methods: Rectangular random-pattern flaps were elevated from the back of each rat. Group I was the control group. In group II 0.1 mL of cineole, in group III 0.1 mL of alpha-pinene, in group IV 0.1 mL of camphor, in group V 0.1 mL each of alpha-pinene and cineole, in group VI 0.1 mL each of alpha-pinene and camphor, in group VII 0...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29915722/new-therapies-and-immunological-findings-in-cutaneous-t-cell-lymphoma
#2
REVIEW
Kazuyasu Fujii
Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin's lymphoma and are characterized by heterogeneous clinical, histological, immunological, and molecular features. The most common type is mycosis fungoides and its leukemic variant, Sézary syndrome. Both diseases are considered T-helper cell type 2 (Th2) diseases. Not only the tumor cells but also the tumor microenvironment can promote Th2 differentiation, which is beneficial for the tumor cells because a Th1 environment enhances antitumor immune responses...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29915720/cancer-immunotherapy-and-the-immune-response-in-hodgkin-lymphoma
#3
REVIEW
Christoph Renner, Frank Stenner
Patients with classical Hodgkin lymphoma (cHL) have an impaired cellular immune response as indicated by an anergic reaction against standard recall antigens and a diminished rejection reaction of allogeneic skin transplant. This clinical observation can be linked to the histopathological feature of cHL since the typical pattern of a cHL manifestation is characterized by sparse large CD30+ tumor-infiltrating Hodgkin-Reed-Sternberg (HRS) cells that are surrounded by a dense inflammatory immune microenvironment with mixed cellularity...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29915691/establishment-of-a-12-gene-expression-signature-to-predict-colon-cancer-prognosis
#4
Dalong Sun, Jing Chen, Longzi Liu, Guangxi Zhao, Pingping Dong, Bingrui Wu, Jun Wang, Ling Dong
A robust and accurate gene expression signature is essential to assist oncologists to determine which subset of patients at similar Tumor-Lymph Node-Metastasis (TNM) stage has high recurrence risk and could benefit from adjuvant therapies. Here we applied a two-step supervised machine-learning method and established a 12-gene expression signature to precisely predict colon adenocarcinoma (COAD) prognosis by using COAD RNA-seq transcriptome data from The Cancer Genome Atlas (TCGA). The predictive performance of the 12-gene signature was validated with two independent gene expression microarray datasets: GSE39582 includes 566 COAD cases for the development of six molecular subtypes with distinct clinical, molecular and survival characteristics; GSE17538 is a dataset containing 232 colon cancer patients for the generation of a metastasis gene expression profile to predict recurrence and death in COAD patients...
2018: PeerJ
https://www.readbyqxmd.com/read/29915597/effects-of-experimental-terrestrialization-on-the-skin-mucus-proteome-of-african-lungfish-protopterus-dolloi
#5
Ryan D Heimroth, Elisa Casadei, Irene Salinas
Animal mucosal barriers constantly interact with the external environment, and this interaction is markedly different in aquatic and terrestrial environments. Transitioning from water to land was a critical step in vertebrate evolution, but the immune adaptations that mucosal barriers such as the skin underwent during that process are essentially unknown. Vertebrate animals such as the African lungfish have a bimodal life, switching from freshwater to terrestrial habitats when environmental conditions are not favorable...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29914578/near-complete-response-to-pembrolizumab-in-microsatellite-stable-metastatic-sebaceous-carcinoma
#6
Evidio Domingo-Musibay, Paari Murugan, Alessio Giubellino, Sandeep Sharma, Daniel Steinberger, Jianling Yuan, Matthew A Hunt, Emil Lou, Jeffrey S Miller
BACKGROUND: Sebaceous carcinoma is an aggressive adnexal skin tumor with a predilection for the eyelids and sebaceous glands of the head and neck. CASE PRESENTATION: A 73 year-old man presented with confusion and was found to have widely disseminated sebaceous carcinoma with metastases to brain, lungs, liver, bowel, lymph nodes, and bone. Following initial treatment of the brain metastases with surgery he received post-operative radiosurgery. He then began systemic immunotherapy with pembrolizumab...
June 19, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29914570/boron-neutron-capture-therapy-for-vulvar-melanoma-and-genital-extramammary-paget-s-disease-with-curative-responses
#7
Junichi Hiratsuka, Nobuhiko Kamitani, Ryo Tanaka, Eisaku Yoden, Ryuji Tokiya, Minoru Suzuki, Rolf F Barth, Koji Ono
BACKGROUND: Although the most commonly recommended treatment for melanoma and extramammary Paget's disease (EMPD) of the genital region is wide surgical excision of the lesion, the procedure is highly invasive and can lead to functional and sexual problems. Alternative treatments have been used for local control when wide local excision was not feasible. Here, we describe four patients with genital malignancies who were treated with boron neutron capture therapy (BNCT). METHODS: The four patients included one patient with vulvar melanoma (VM) and three with genital EMPD...
June 19, 2018: Cancer communications
https://www.readbyqxmd.com/read/29914105/the-extract-of-d-dasycarpus-ameliorates-oxazolone-induced-skin-damage-in-mice-by-anti-inflammatory-and-antioxidant-mechanisms
#8
Tsong-Min Chang, Ting-Ya Yang, Yu-Lin Niu, Huey-Chun Huang
Dictamni dasycarpus is a type of Chinese medicine made from the root bark of D. dasycarpus . It has been reported to show a wide spectrum of biological and pharmacological effects, for example, it has been used widely for the treatment of rheumatism, nettle rash, itching, jaundice, chronic hepatitis and skin diseases. In the current study, D. dasycarpus extract was investigated for its antioxidant and anti-inflammatory effects, as well as its capability to alleviate oxazolone-induced skin damage in mice. The possible anti-inflammatory mechanism of D...
June 15, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29913261/hydrochlorothiazide-use-and-risk-of-merkel-cell-carcinoma-and-malignant-adnexal-skin-tumors-a-nationwide-case-control-study
#9
Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Lisbet Rosenkrantz Hölmich, Søren Friis, Anton Pottegård, David Gaist
BACKGROUND: Hydrochlorothiazide use has been associated with markedly increased risk of squamous cell carcinoma. No previous studies have investigated the association between hydrochlorothiazide use and the risk of Merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST). OBJECTIVE: To examine the association between hydrochlorothiazide use and the risk of MCC and MAST. METHODS: Using Danish nationwide health registries, we identified all patients with incident MCC or MAST during 2004-2015 and matched cases individually to cancer-free population controls by risk set sampling...
June 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29911527/basal-cell-carcinoma-of-the-buttock
#10
REVIEW
Philip R Cohen
Basal cell carcinoma of the buttock is rare, and only 28 patients have been described. An extensive literature search was performed on basal cell carcinoma and buttock using the PubMed database. The literature was evaluated, and the characteristics of individuals with basal cell carcinoma of the buttock were summarized. The calculated prevalence of basal cell carcinoma of the buttock was 0.35%. The majority of patients had no obvious basal cell carcinoma-associated risk factors. Carcinomas were observed 1.2 times more often in women than in men, and more often on the right buttock...
2018: Skinmed
https://www.readbyqxmd.com/read/29910732/bleomycin-aggravates-atopic-dermatitis-via-lung-inflammation-in-2-4-dinitrochlorobenzene-induced-nc-nga-mice
#11
Yoon-Young Sung, Seung-Hyung Kim, Won-Kyung Yang, Yang-Chun Park, Ho Kyoung Kim
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Bleomycin (BLM) contributes to the induction of pulmonary inflammation and fibrosis in animals. Although skin and lung tissue inflammation is closely related in the pathogenesis of allergic diseases, a proper animal model for investigating the relationship between skin and lung inflammation is lacking. Therefore, we developed a mouse model of AD with relapsing dermatitis and pulmonary fibrosis caused by the administration of allergen and BLM. The present study determined whether lung injury caused by the bronchial application of BLM would exacerbate AD-like allergic inflammation induced by 2, 4-dinitrochlorobenzene (DNCB) in NC/Nga mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29909407/familial-forms-of-cushing-syndrome-in-primary-pigmented-nodular-adrenocortical-disease-presenting-with-short-stature-and-insidious-symptoms-a-clinical-series
#12
Constanza Navarro Moreno, Amaury Delestienne, Etienne Marbaix, Selda Aydin, Konstanze Hörtnagel, Sarah Lechner, Yves Sznajer, Véronique Beauloye, Dominique Maiter, Philippe A Lysy
Cushing syndrome (CS) is a rare disease in children, frequently associated with subtle or periodic symptoms that may delay its diagnosis. Weight gain and growth failure, the hallmarks of hypercortisolism in pediatrics, may be inconsistent, especially in ACTH-independent forms of CS. Primary pigmented nodular adrenocortical disease (PPNAD) is the rarest form of ACTH-independent CS, and can be associated with endocrine and nonendocrine tumors, forming the Carney complex (CNC). Recently, phenotype/genotype correlations have been described with particular forms of CNC where PPNAD is isolated or associated only with skin lesions...
June 15, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29909227/classification-of-non-tumorous-skin-pigmentation-disorders-using-voting-based-probabilistic-linear-discriminant-analysis
#13
Yunfeng Liang, Lei Sun, Wee Ser, Feng Lin, Steven Tien Guan Thng, Qiping Chen, Zhiping Lin
Non-tumorous skin pigmentation disorders can have a huge negative emotional impact on patients. The correct diagnosis of these disorders is essential for proper treatments to be instituted. In this paper, we present a computerized method for classifying five non-tumorous skin pigmentation disorders (i.e., freckles, lentigines, Hori's nevus, melasma and nevus of Ota) based on probabilistic linear discriminant analysis (PLDA). To address the large within-class variance problem with pigmentation images, a voting based PLDA (V-PLDA) approach is proposed...
June 5, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29908976/effects-of-methylene-blue-mediated-photodynamic-therapy-on-a-mouse-model-of-squamous-cell-carcinoma-and-normal-skin
#14
Ana Paula da Silva, Camila Lima Neves, Elizangela Dos Anjos Silva, Tania Cristina Lima Portela, Renata Stecca Iunes, Bruno Cogliati, Divinomar Severino, Maurício da Silva Baptista, Maria Lúcia Zaidan Dagli, Francisco Javier Hernandez Blazquez, José Roberto Machado Cunha da Silva
BACKGROUND: Photodynamic therapy is used to treat a variety of cancers and skin diseases by inducing apoptosis, necrosis, immune system activation, and/or vascular damage. Here, we describe the effects of a single photodynamic therapy session using methylene blue on a mouse model of squamous cell carcinoma and normal skin. METHODS: The photodynamic therapy protocol comprised application of a 1% methylene blue solution, followed by irradiation with a diode laser for 15 min at 74 mW/cm2 , for a total dose of 100 J/cm2 ...
June 14, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29908105/phase-ii-trial-of-biweekly-cetuximab-and-irinotecan-as-third-line-therapy-for-pretreated-kras-exon-2-wild-type-colorectal-cancer
#15
Hiroki Osumi, Eiji Shinozaki, Tetsuo Mashima, Takeru Wakatsuki, Mitsukuni Suenaga, Takashi Ichimura, Mariko Ogura, Yumiko Ota, Izuma Nakayama, Daisuke Takahari, Keisho Chin, Yoshio Miki, Kensei Yamaguchi
Efficacy and safety of biweekly cetuximab plus irinotecan were evaluated to provide guidance for its use in Japan as third-line treatment for pretreated metastatic colorectal cancer patients harboring wild-type KRAS Exon 2. Objective response rate was used as primary endpoint based on an expected proportion of 0.23 with confidence width of 0.298 (95% confidence interval, 0.105-0.403), which showed 35 to be the minimal participant number. Forty patients, refractory to first- and second-line chemotherapy containing irinotecan, oxaliplatin, and fluoropyrimidine were enrolled...
June 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29907740/single-breath-hold-photoacoustic-computed-tomography-of-the-breast
#16
Li Lin, Peng Hu, Junhui Shi, Catherine M Appleton, Konstantin Maslov, Lei Li, Ruiying Zhang, Lihong V Wang
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scanning the entire breast within a single breath hold (~15 s), a volumetric image can be acquired and subsequently reconstructed utilizing 3D back-projection with negligible breathing-induced motion artifacts...
June 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29906546/association-between-breslow-thickness-and-dermoscopic-findings-in-acral-melanoma
#17
Je-Ho Mun, Gwanghyun Jo, Claudia C Darmawan, Jin Park, Jung Min Bae, HyunJu Jin, Woo-Il Kim, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
BACKGROUND: Dermoscopy is a useful tool for the diagnosis of acral melanomas (AM). However, little is known about the influence of tumor thickness on the dermoscopic findings of AM. OBJECTIVE: To investigate the impact of Breslow thickness (BT) on the dermoscopic patterns of AM. METHODS: Data on cases of AM on the glabrous skin were collected from four university hospitals. We investigated the frequency of each dermoscopic feature of AM according to the BT...
June 12, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29906314/gromwell-lithospermum-erythrorhizon-root-extract-protects-against-glycation-and-related-inflammatory-and-oxidative-stress-while-offering-uv-absorption-capability
#18
Kelly M Glynn, Penny Anderson, David J Fast, James Koedam, John F Rebhun, Rodney A Velliquette
Glycation and advanced glycation endproducts (AGE) damage skin which is compounded by AGE-induced oxidative stress and inflammation. Lip and facial skin could be susceptible to glycation damage as they are chronically stressed. As Gromwell (Lithospermum erythrorhizon) root (GR) has an extensive traditional medicine history that includes providing multiple skin benefits, our objective was to determine if GR extract and its base naphthoquinone, shikonin, might protect skin by inhibiting glycation, increasing oxidative defenses, suppressing inflammatory responses, and offering ultraviolet (UV) absorptive potential in lip and facial cosmetic matrices...
June 15, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29905608/the-gracilis-free-flap-is-a-viable-option-for-large-extremity-wounds
#19
Nicholas A Calotta, Rachel Pedreira, E Gene Deune
BACKGROUND: Traditionally, the gracilis free flap is used for coverage of small- to medium-sized wounds (<50 cm) or as a functional muscle transfer. The purpose of this study is to examine the use of the gracilis free flap in the reconstruction of large extremity wounds (>100 cm). METHODS: We retrospectively reviewed records of 34 patients who underwent extremity soft-tissue reconstruction using gracilis free flaps for wounds larger than 100 cm from 1998 to 2016...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29904586/recent-advances-in-field-cancerization-and-management-of-multiple-cutaneous-squamous-cell-carcinomas
#20
REVIEW
Sean R Christensen
Cutaneous squamous cell carcinoma (SCC) is among the most common cancers in humans, and many patients with SCC will develop multiple tumors within their lifetime. The field cancerization concept, originally proposed over 60 years ago, hypothesized that multiple primary cancers may arise simultaneously and coexist with subclinical precursor lesions within a defined field. Genetic sequencing of SCC and precursor lesions has identified what may be the earliest clonal proliferations in SCC development and confirmed that field cancerization in the skin is mediated by ultraviolet radiation...
2018: F1000Research
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