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https://www.readbyqxmd.com/read/28914304/high-accuracy-and-high-sensitivity-spectroscopic-measurement-of-dinitrogen-pentoxide-n2o5-in-an-atmospheric-simulation-chamber-using-a-quantum-cascade-laser
#1
Hongming Yi, Tao Wu, Amélie Lauraguais, Vladimir Semenov, Cecile Coeur, Andy Cassez, Eric Fertein, Xiaoming Gao, Weidong Chen
A spectroscopic instrument based on a mid-infrared external cavity quantum cascade laser (EC-QCL) was developed for high-accuracy measurements of dinitrogen pentoxide (N2O5) at the ppbv-level. A specific concentration retrieval algorithm was developed to remove, from the broadband absorption spectrum of N2O5, both etalon fringes resulting from the EC-QCL intrinsic structure and spectral interference lines of H2O vapour absorption, which led to a significant improvement in measurement accuracy and detection sensitivity (by a factor of 10), compared to using a traditional algorithm for gas concentration retrieval...
September 15, 2017: Analyst
https://www.readbyqxmd.com/read/28913655/quantitative-trait-loci-for-resistance-to-stripe-rust-of-wheat-revealed-using-global-field-nurseries-and-opportunities-for-stacking-resistance-genes
#2
Firdissa E Bokore, Richard D Cuthbert, Ron E Knox, Harpinder S Randhawa, Colin W Hiebert, Ron M DePauw, Asheesh K Singh, Arti Singh, Andrew G Sharpe, Amidou N'Diaye, Curtis J Pozniak, Curt McCartney, Yuefeng Ruan, Samia Berraies, Brad Meyer, Catherine Munro, Andy Hay, Karim Ammar, Julio Huerta-Espino, Sridhar Bhavani
Quantitative trait loci controlling stripe rust resistance were identified in adapted Canadian spring wheat cultivars providing opportunity for breeders to stack loci using marker-assisted breeding. Stripe rust or yellow rust, caused by Puccinia striiformis Westend. f. sp. tritici Erikss., is a devastating disease of common wheat (Triticum aestivum L.) in many regions of the world. The objectives of this research were to identify and map quantitative trait loci (QTL) associated with stripe rust resistance in adapted Canadian spring wheat cultivars that are effective globally, and investigate opportunities for stacking resistance...
September 14, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28912378/systematic-mutagenesis-of-serine-hydroxymethyltransferase-reveals-essential-role-in-nematode-resistance
#3
Pramod K Kandoth, Shiming Liu, Elizabeth Prenger, Andrew Ludwig, Naoufal Lakhssassi, Robert Heinz, Zhou Zhou, Amanda Howland, Joshua Gunther, Samantha Eidson, Andi Dhroso, Peter Lafayette, Donna Tucker, Sarah Elizabeth Johnson, James Anderson, Alaa Alaswad, Silvia Cianzio, Wayne Allen Parrott, Dmitry Korkin, Khalid Meksem, Melissa G Mitchum
Rhg4 is a major genetic locus that contributes to soybean cyst nematode (SCN) resistance in the Peking-type resistance of soybean, which also requires the rhg1 gene. By map-based cloning and functional genomic approaches, we previously showed that the Rhg4 gene encodes a predicted cytosolic serine hydroxymethyltransferase (GmSHMT08); however, the novel gain of function of GmSHMT08 in SCN resistance remains to be characterized. Using a forward genetic screen, we identified an allelic series of GmSHMT08 mutants that shed new light on the mechanistic aspects of GmSHMT08-mediated resistance...
September 14, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28911920/after-asthma-redefining-airways-diseases
#4
REVIEW
Ian D Pavord, Richard Beasley, Alvar Agusti, Gary P Anderson, Elisabeth Bel, Guy Brusselle, Paul Cullinan, Adnan Custovic, Francine M Ducharme, John V Fahy, Urs Frey, Peter Gibson, Liam G Heaney, Patrick G Holt, Marc Humbert, Clare M Lloyd, Guy Marks, Fernando D Martinez, Peter D Sly, Erika von Mutius, Sally Wenzel, Heather J Zar, Andy Bush
No abstract text is available yet for this article.
September 11, 2017: Lancet
https://www.readbyqxmd.com/read/28911131/addressing-challenges-to-human-health-in-the-anthropocene-epoch-an-overview-of-the-findings-of-the-rockefeller-lancet-commission-on-planetary-health
#5
Andy Haines
No abstract text is available yet for this article.
September 1, 2017: International Health
https://www.readbyqxmd.com/read/28911119/a-snorna-modulates-mrna-3-end-processing-and-regulates-the-expression-of-a-subset-of-mrnas
#6
Chunliu Huang, Junjie Shi, Yibin Guo, Weijun Huang, Shanshan Huang, Siqi Ming, Xingui Wu, Rui Zhang, Junjun Ding, Wei Zhao, Jie Jia, Xi Huang, Andy Peng Xiang, Yongsheng Shi, Chengguo Yao
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown whether RNAs play any role in this process. Unexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' processing complex. These snoRNAs primarily interact with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF)...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28904805/high-dose-levothyroxine-for-the-management-of-bipolar-affective-disorder-two-case-reports
#7
Andy Zamar, Gurvinder Warrya, Christos Kouimtsidis
In this article, we report two cases from our centre: case A has the longest recovery period and case B is one of the most complex from a diagnostic and management perspective, highlighting how treatment resistance can be overcome depending on patient response and needs.
September 2017: JRSM Open
https://www.readbyqxmd.com/read/28903875/risk-assessment-of-the-entry-of-canine-rabies-into-papua-new-guinea-via-sea-and-land-routes
#8
Victoria J Brookes, Andy Keponge-Yombo, David Thomson, Michael P Ward
Canine-rabies is endemic in parts of Indonesia and continues to spread eastwards through the Indonesian archipelago. Papua New Guinea (PNG) has a land border with Papua Province, Indonesia, as well as logging and fishing industry connections throughout Asia. PNG has a Human Development Index of 0.505; therefore, an incursion of canine-rabies could have devastating impacts on human (7.5 million) and animal populations. Given the known difficulties of rabies elimination in resource-scarce environments, an incursion of rabies into PNG would also likely compromise the campaign for global elimination of rabies...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28903524/pediatric-dental-clinic-associated-outbreak-of-mycobacterium-abscessus-infection
#9
Lindsay A Hatzenbuehler, Melissa Tobin-D'Angelo, Cherie Drenzek, Gianna Peralta, Lisa C Cranmer, Evan J Anderson, Sarah S Milla, Shelly Abramowicz, Jumi Yi, Joseph Hilinski, Roy Rajan, Matthew K Whitley, Verlia Gower, Frank Berkowitz, Craig A Shapiro, Joseph K Williams, Paula Harmon, Andi L Shane
Background: Mycobacterium abscessus is an uncommon cause of invasive odontogenic infection. Methods: M abscessus-associated odontogenic infections occurred in a group of children after they each underwent a pulpotomy. A probable case-child was defined as a child with facial or neck swelling and biopsy-confirmed granulomatous inflammation after a pulpotomy between October 1, 2013, and September 30, 2015. M abscessus was isolated by culture in confirmed case-children...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28903501/sex-differential-responses-of-tumor-promotion-associated-genes-and-dysregulation-of-novel-long-noncoding-rnas-in-constitutive-androstane-receptor-activated-mouse-liver
#10
Nicholas J Lodato, Tisha Melia, Andy Rampersaud, David J Waxman
Xenobiotic agonists of constitutive androstane receptor (CAR) induce many hepatic drug metabolizing enzymes, but following prolonged exposure, promote hepatocellular carcinoma, most notably in male mouse liver. Here, we used nuclear RNA-seq to characterize global changes in the mouse liver transcriptome following exposure to the CAR-specific agonist ligand 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), including changes in novel long noncoding RNAs that may contribute to xenobiotic-induced pathophysiology...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28902877/purification-and-characterization-of-a-highly-specific-polyclonal-antibody-against-human-extracellular-signal-regulated-kinase-8-and-its-detection-in-lung-cancer
#11
Na-Li Cai, Andy T Y Lau, Fei-Yuan Yu, Dan-Dan Wu, Li-Juan Dai, Hai-Ying Mo, Chang-Min Lin, Yan-Ming Xu
Extracellular signal-regulated kinase 8 (ERK8), proposed as a novel potential therapeutic target for cancer, has been implicated in cell transformation, apoptosis, the protection of genomic integrity, and autophagy. To facilitate ERK8 research, a highly specific anti-ERK8 antibody is needed. In this article, we use the Immune Epitope Database and Analysis Resource online tool to predict B-cell epitopes of human ERK8 protein, and choose a 28 aa-peptide sequence to generate the GST-ERK8(28aa) fusion protein as the antigen for developing polyclonal antibody against ERK8...
2017: PloS One
https://www.readbyqxmd.com/read/28902102/post-traumatic-spinal-hygroma-causing-cord-compression-in-type-iii-odontoid-fracture-with-vertical-atlantoaxial-instability
#12
Salvatore Russo, Antonio Belli, Andy Eynon, Ali Nader-Sepahi
STUDY DESIGN: Case report. OBJECTIVE: To report the first case in the literature of a traumatic cervical spine subdural cerebrospinal fluid (CSF) collection (hygroma) under tension causing cord compression. We suggest etiopathogenesis and modality of treatment. SUMMARY OF BACKGROUND DATA: Hygromas are subdural cranial CSF collection. A literature review showed no previous published case of post-traumatic spinal hygroma. This was a potential life-threatening sequelae of a high cervical injury that warranted early diagnosis and emergency treatment...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28901127/barrier-layer-optimization-for-enhanced-gan-on-diamond-device-cooling
#13
Yan Zhou, Julian Anaya, James Pomeroy, Huarui Sun, Xing Gu, Andy Xie, Edward Beam, Michael Becker, Timothy Grotjohn, Cathy Lee, Martin Kuball
GaN-on-diamond device cooling can be enhanced by reducing the effective thermal boundary resistance (TBReff) of the GaN/diamond interface. The thermal properties of this interface and of the polycrystalline diamond grown onto GaN using SiN and AlN barrier layers, as well as without any barrier layer under different growth conditions are investigated and systematically compared for the first time. TBReff values are correlated with transmission electron microscopy analysis, showing that a lowest reported TBReff (~6...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28899556/a-multi-institutional-comparison-of-sbrt-and-imrt-for-definitive-reirradiation-of-recurrent-or-second-primary-head-and-neck-cancer
#14
John A Vargo, Matthew C Ward, Jimmy J Caudell, Nadeem Riaz, Neal E Dunlap, Derek Isrow, Sara J Zakem, Joshua Dault, Musaddiq J Awan, Kristin A Higgins, Comron Hassanadeh, Jonathan J Beitler, Chandana A Reddy, Samuel Marcrom, Drexell H Boggs, James A Bonner, Min Yao, Mitchell Machtay, Farzan Siddiqui, Andy M Trotti, Nancy Y Lee, Shlomo A Koyfman, Robert L Ferris, Dwight E Heron
PURPOSE: Two modern methods of reirradiation, intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), are established for patients with recurrent or second primary squamous cell carcinoma of the head and neck (rSCCHN). We performed a retrospective multi-institutional analysis to compare methods. METHODS AND MATERIALS: Data from patients with unresectable rSCCHN previously irradiated to ≥40 Gy who underwent reirradiation with IMRT or SBRT were collected from 8 institutions...
April 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28898106/anterolateral-tenodesis-or-anterolateral-ligament-complex-reconstruction-effect-of-flexion-angle-at-graft-fixation-when-combined-with-acl-reconstruction
#15
Eivind Inderhaug, Joanna M Stephen, Andy Williams, Andrew A Amis
BACKGROUND: Despite numerous technical descriptions of anterolateral procedures, knowledge is limited regarding the effect of knee flexion angle during graft fixation. PURPOSE: To determine the effect of knee flexion angle during graft fixation on tibiofemoral joint kinematics for a modified Lemaire tenodesis or an anterolateral ligament (ALL) complex reconstruction combined with anterior cruciate ligament (ACL) reconstruction. STUDY DESIGN: Controlled laboratory study...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28893243/impact-of-pharmacy-worker-training-and-deployment-on-access-to-essential-medicines-for-children-under-five-in-malawi-a-cluster-quasi-experimental-evaluation
#16
Joseph B Babigumira, Solomon J Lubinga, Alisa M Jenny, Erin Larsen-Cooper, Jessica Crawford, Charles Matemba, Andy Stergachis
BACKGROUND: Poor access to essential medicines is common in many low- and middle-income countries, partly due to an insufficient and inadequately trained workforce to manage the medicines supply chain. We conducted a prospective impact evaluation of the training and deployment of pharmacy assistants (PAs) to rural health centers in Malawi. METHODS: A quasi-experimental design was used to compare access to medicines in two districts where newly trained PAs were deployed to health centers (intervention) and two districts with no trained PAs at health centers (comparison)...
September 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28892612/medium-chain-length-polyhydroxyalkanoate-copolymer-modified-by-bacterial-cellulose-for-medical-devices
#17
Denis Mihaela Panaitescu, Irina Lupescu, Adriana Nicoleta Frone, Ioana Chiulan, Cristian Andi Nicolae, Vlad Tofan, Amalia Stefaniu, Raluca Somoghi, Roxana Trusca
Medium chain-length PHAs (mPHAs) are flexible elastomeric biopolymers with valuable properties for biomedical applications like artificial arteries and other medical implants. However, an environmentally friendly and high productivity process together with the tuning of the mechanical and biological properties of mPHAs are mandatory for this purpose. Here, for the first time, a melt processing technique was applied for the preparation of bionanocomposites starting from poly(3-hydroxyoctanoate) (PHO) and bacterial cellulose nanofibers (BC)...
September 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28890892/microrna-profiling-in-cartilage-ageing
#18
Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter Clegg, Yongxiang Fang, Andy Cremers, Pieter Emans, Tim Welting, Mandy Peffers
Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28890757/populations-of-rice-grain-bug-paraeuscosmetus-pallicomis-hemiptera-lygaeidae-in-weed-free-paddy-field-weedy-paddy-field-and-paddy-dykes
#19
Tamrin Abdullah, Andi Nasruddin, Nurariaty Agus
Research on the populations of rice grain bug Paraeuscosmetus pallicomis Dallas (Hemiptera: Lygaeidae) in paddy field ecosystems was performed with the aim to determine the populations of rice grain bug in weed-free paddy field, weedy paddy field, and paddy dykes. Experiment was carried out in the village of Paccellekang in the district of Patallasang of Gowa Regency in South Sulawesi, Indonesia. Observations were performed during the milky grain stage (85 days after planting), the mature grain stage (105 days after planting), and one day after harvest (115 days after transplanting)...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28888032/close-but-no-cigar-spatial-precision-deficits-following-medial-temporal-lobe-lesions-provide-novel-insight-into-theoretical-models-of-navigation-and-memory
#20
Branden S Kolarik, Trevor Baer, Kiarash Shahlaie, Andy P Yonelinas, Arne D Ekstrom
Increasing evidence suggests that the human hippocampus contributes to a range of different behaviors, including episodic memory, language, short-term memory, and navigation. A novel theoretical framework, the Precision and Binding Model, accounts for these phenomenon by describing a role for the hippocampus in high-resolution, complex binding. Other theories like Cognitive Map Theory, in contrast, predict a specific role for the hippocampus in allocentric navigation, while Declarative Memory Theory predicts a specific role in delay-dependent conscious memory...
September 9, 2017: Hippocampus
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