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https://www.readbyqxmd.com/read/29781933/repeated-exposure-to-taekwondo-combat-modulates-the-physiological-and-hormonal-responses-to-subsequent-bouts-and-recovery-periods
#1
Craig A Bridge, Andy S Sparks, Lars R McNaughton, Graeme L Close, Matheus Hausen, Jonas Gurgel, Barry Drust
Bridge, CA, Sparks, SA, McNaughton, LR, Close, GL, Hausen, M, Gurgel, J, and Drust, B. Repeated exposure to taekwondo combat modulates the physiological and hormonal responses to subsequent bouts and recovery periods. J Strength Cond Res XX(X): 000-000, 2018-This study examined the physiological and hormonal responses to successive taekwondo combats using an ecologically valid competition time structure. Ten elite male international taekwondo competitors (age 19 ± 3 years) took part in a simulated championship event...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29781296/variation-in-essential-oil-composition-of-teucrium-hircanicum-l-from-iran-a-rich-source-of-e-%C3%AE-bergamotene
#2
Mohammad Ali Rahimi, Vahideh Nazeri, Seyed Ali Andi, Fatemeh Sefidkon
In present work, the chemical composition of the essential oils obtained from dried flowering aerial parts of Teucrium hircanicum L. (Labiatae) originated from ten wild populations in Iran was analyzed by a GC-FID and GC/MS system. The oil yields varied from 0.04% to 0.1%. A total of thirty-two compounds representing 67.6-97.7% of the oil were identified. The essential oil was found to be rich in sesquiterpene hydrocarpons (E)-α-bergamotene (17.5-86.9%) and (E)-β-farnesene (0.5-21.4%). Of the total identified compounds, sesquiterpene hydrocarpons (36...
May 21, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29780657/characterizing-cellular-mechanical-phenotypes-with-mechano-node-pore-sensing
#3
Junghyun Kim, Sewoon Han, Andy Lei, Masaru Miyano, Jessica Bloom, Vasudha Srivastava, Martha M Stampfer, Zev J Gartner, Mark A LaBarge, Lydia L Sohn
The mechanical properties of cells change with their differentiation, chronological age, and malignant progression. Consequently, these properties may be useful label-free biomarkers of various functional or clinically relevant cell states. Here, we demonstrate mechano-node-pore sensing (mechano-NPS), a multi-parametric single-cell-analysis method that utilizes a four-terminal measurement of the current across a microfluidic channel to quantify simultaneously cell diameter, resistance to compressive deformation, transverse deformation under constant strain, and recovery time after deformation...
2018: Microsystems & Nanoengineering
https://www.readbyqxmd.com/read/29778942/transcriptomic-and-methylomic-analysis-reveal-the-toxicological-effect-of-2-3-7-8-tetrachlorodibenzodioxin-on-human-embryonic-stem-cell
#4
Keng Po Lai, Jing Woei Li, Ting Fung Chan, Andy Chen, Cherie Yin Lau Lee, William Shu Biu Yeung, Chris Kong Chu Wong
Cumulating epidemiological studies demonstrated that environmental exposure to endocrine disrupting chemicals (EDCs) during the early stages of fetal development is associated with the increase in disease susceptibility in later life. The fetal developmental plasticity is considered as a protective mechanism against an undesirable prenatal environment. Dioxin is one of the environmental contaminants and is considered a diabetogenic factor. Experimental animal and human epidemiological studies have revealed that dioxin exposure was associated with insulin resistance and altered beta cell function...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29777508/endothelial-progenitor-cells-in-heart-failure-an-authentic-expectation-for-potential-future-use-and-a-lack-of-universal-definition
#5
REVIEW
Andie H Djohan, Ching-Hui Sia, Poay Sian Lee, Kian-Keong Poh
Congestive heart failure (CHF) is a prevalent disease (especially among the elderly) with high mortality and morbidity rates. The pathological hallmark of CHF is a loss of cardiomyocytes leading to cardiac fibrosis and dysfunctional cardiac remodeling, which culminates in organ failure. Endothelial progenitor cells (EPCs) are bone marrow-derived cells that contribute to maintenance of the integrity of endothelial wall and protect ischemic myocardium through forming new blood vessels (vasculogenesis) or proliferation of pre-existing vasculature (angiogenesis)...
May 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29775662/multivoxel-pattern-similarity-suggests-the-integration-of-temporal-duration-in-hippocampal-event-sequence-representations
#6
Sathesan Thavabalasingam, Edward B O'Neil, Andy C H Lee
Recent rodent work suggests the hippocampus may provide a temporal representation of event sequences, in which the order of events and the interval durations between them are encoded. There is, however, limited human evidence for the latter, in particular whether the hippocampus processes duration information pertaining to the passage of time rather than qualitative or quantitative changes in event content. We scanned participants while they made match/mismatch judgements on each trial between a study sequence of events and a subsequent test sequence...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29774846/occupation-associated-fatal-limbic-encephalitis-caused-by-variegated-squirrel-bornavirus-1-germany-2013
#7
Dennis Tappe, Kore Schlottau, Daniel Cadar, Bernd Hoffmann, Lorenz Balke, Burkhard Bewig, Donata Hoffmann, Philip Eisermann, Helmut Fickenscher, Andi Krumbholz, Helmut Laufs, Monika Huhndorf, Maria Rosenthal, Walter Schulz-Schaeffer, Gabriele Ismer, Sven-Kevin Hotop, Mark Brönstrup, Anthonina Ott, Jonas Schmidt-Chanasit, Martin Beer
Limbic encephalitis is commonly regarded as an autoimmune-mediated disease. However, after the recent detection of zoonotic variegated squirrel bornavirus 1 in a Prevost's squirrel (Callosciurus prevostii) in a zoo in northern Germany, we retrospectively investigated a fatal case in an autoantibody-seronegative animal caretaker who had worked at that zoo. The virus had been discovered in 2015 as the cause of a cluster of cases of fatal encephalitis among breeders of variegated squirrels (Sciurus variegatoides) in eastern Germany...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774792/hypofractionated-radiotherapy-is-superior-to-conventional-fractionation-in-an-orthotopic-model-of-anaplastic-thyroid-cancer
#8
Ayman J Oweida, Andy Phan, Benjamin Vancourt, Tyler Robin, Mohammad K Hararah, Shilpa Bhatia, Dallin Milner, Shelby Lennon, Laura Pike, David Raben, Bryan R Haugen, Nikita Pozdeyev, Rebecca E Schweppe, Sana D Karam
Anaplastic thyroid cancer is an aggressive and highly lethal disease with poor outcomes and resistance to therapy. Despite multimodality treatment including radiation therapy and chemotherapy, response rates remain below 15% with a median time to progression of less than 3 months. Recent advances in radiotherapy delivery and gene-expression profiling may help guide patient selection for personalized therapy. The purpose of this study was to characterize the response to radiation in a panel of ATC cell lines and to test alternative radiotherapy fractionation schedules for overcoming radioresistance...
May 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29774120/carboplatin-in-combination-with-weekly-paclitaxel-as-first-line-therapy-in-patients-with-recurrent-metastatic-head-and-neck-squamous-cell-carcinoma-unfit-to-extreme-schedule
#9
Adeline Pêtre, Cécile Dalban, Andy Karabajakian, Eve-Marie Neidhardt, Pierre Eric Roux, Marc Poupart, Sophie Deneuve, Philippe Zrounba, Jérome Fayette
The standard first-line treatment in recurrent/metastatic head and neck squamous cell carcinoma combines Cisplatin, 5 Fluorouracil and Cetuximab, but many patients aren't eligible. We retrospectively evaluated the efficacy and the tolerability of Carboplatin and Paclitaxel in this indication, mostly in patients unfit to Cisplatin. Paclitaxel (80mg/m2) was administered at day 1, 8 and 15 and Carboplatin area under the curve 5 at day 1, repeated every 28 days, for 6 cycles. Carboplatin could be administered at area under the curve 2 at day 1, 8 and 15...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773577/determinants-and-outcomes-of-vasoplegia-following-left-ventricular-assist-device-implantation
#10
Kristen M Tecson, Brian Lima, Andy Y Lee, Fayez S Raza, Grace Ching, Cheng-Han Lee, Joost Felius, Ronald D Baxter, Sasha Still, Justin D G Collier, Shelley A Hall, Susan M Joseph
BACKGROUND: Vasoplegia is associated with adverse outcomes following cardiac surgery; however, its impact following left ventricular assist device implantation is largely unexplored. METHODS AND RESULTS: In 252 consecutive patients receiving a left ventricular assist device, vasoplegia was defined as the occurrence of normal cardiac function and index but with the need for intravenous vasopressors within 48 hours following surgery for >24 hours to maintain a mean arterial pressure >70 mm Hg...
May 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29773516/lymphoedema-management-to-prevent-acute-dermatolymphangioadenitis-in-podoconiosis-in-northern-ethiopia-golbet-a-pragmatic-randomised-controlled-trial
#11
Henok Negussie, Meseret Molla, Moses Ngari, James A Berkley, Esther Kivaya, Patricia Njuguna, Greg Fegan, Abreham Tamiru, Abebe Kelemework, Trudie Lang, Melanie J Newport, Andy McKay, Fikre Enquoselassie, Gail Davey
BACKGROUND: Podoconiosis (also known as endemic, non-filarial elephantiasis) affects about 4 million subsistence farmers in tropical Africa. Poor awareness of the condition and inadequate evidence for the efficacy of treatment mean that no government in an endemic country yet offers lymphoedema management for patients with podoconiosis. Among patients with filarial lymphoedema, trials suggest that limb care is effective in reducing the most disabling sequelae: episodes of acute dermatolymphangioadenitis...
May 14, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29772807/63-km-bofda-for-temperature-and-strain-monitoring
#12
Thomas Kapa, Andy Schreier, Katerina Krebber
We demonstrate (and are the first to do so) 63 km Brillouin Optical Frequency-Domain Analysis (BOFDA) for temperature and strain monitoring using a 100 km fiber loop. The use of BOFDA for long-range applications can be considered a novel approach, as previous investigations focused on the utilization of Brillouin Optical Time-Domain Reflectometry and Analysis (BOTDR and BOTDA, respectively). At 51.7 km, a 100 m hotspot (37 ∘ C) was detected without using distributed Raman amplification or image processing...
May 17, 2018: Sensors
https://www.readbyqxmd.com/read/29772279/pc-facs-may-1-2018
#13
Andie Bernard
No abstract text is available yet for this article.
May 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29772001/correction-using-the-normalization-process-theory-to-qualitatively-explore-sense-making-in-implementation-of-the-enhanced-recovery-after-surgery-programme-it-s-not-rocket-science
#14
Eileen Sutton, Georgia Herbert, Sorrel Burden, Stephen Lewis, Steve Thomas, Andy Ness, Charlotte Atkinson
[This corrects the article DOI: 10.1371/journal.pone.0195890.].
2018: PloS One
https://www.readbyqxmd.com/read/29770748/the-effect-of-switching-protease-inhibitors-to-raltegravir-on-endothelial-function-in-hiv-infected-patients
#15
Maaike Krikke, Kiki Tesselaar, Guido E L van den Berk, Sigrid A Otto, Laura H Freriks, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman, Joop E Arends
Objective Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may cause dyslipidaemia, whilst the integrase inhibitor raltegravir (RAL) has a relatively favorable effect on plasma lipids. We examined the effect of switching from PIs to RAL on endothelial function, and its effect on immunological and inflammatory parameters. Methods We performed a 16-week open-label prospective crossover study: 8 weeks intervention (switch PIs to RAL) and 8 weeks control (unchanged cART regimen)...
April 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29769723/structure-of-a-volume-regulated-anion-channel-of-the-lrrc8-family
#16
Dawid Deneka, Marta Sawicka, Andy K M Lam, Cristina Paulino, Raimund Dutzler
Volume-regulated anion channels are activated in response to hypotonic stress. These channels are composed of closely related paralogues of the leucine-rich repeat-containing protein 8 (LRRC8) family that co-assemble to form hexameric complexes. Here, using cryo-electron microscopy and X-ray crystallography, we determine the structure of a homomeric channel of the obligatory subunit LRRC8A. This protein conducts ions and has properties in common with endogenous heteromeric channels. Its modular structure consists of a transmembrane pore domain followed by a cytoplasmic leucine-rich repeat domain...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769563/expressed-repetitive-elements-are-broadly-applicable-reference-targets-for-normalization-of-reverse-transcription-qpcr-data-in-mice
#17
Marjolijn Renard, Suzanne Vanhauwaert, Marine Vanhomwegen, Ali Rihani, Niels Vandamme, Steven Goossens, Geert Berx, Pieter Van Vlierberghe, Jody J Haigh, Bieke Decaesteker, Jolien Van Laere, Irina Lambertz, Frank Speleman, Jo Vandesompele, Andy Willaert
Reverse transcription quantitative PCR (RT-qPCR) is the gold standard method for gene expression analysis on mRNA level. To remove experimental variation, expression levels of the gene of interest are typically normalized to the expression level of stably expressed endogenous reference genes. Identifying suitable reference genes and determining the optimal number of reference genes should precede each quantification study. Popular reference genes are not necessarily stably expressed in the examined conditions, possibly leading to inaccurate results...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769195/osteocyte-driven-downregulation-of-snail-restrains-effects-of-drd2-inhibitors-on-mammary-tumor-cells
#18
Shengzhi Liu, Yao Fan, Andy Chen, Aydin Jalali, Kazumasa Minami, Kazuhiko Ogawa, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota
While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents. Here we examined the effect of two FDA-approved dopamine modulators, Fluphenazine (FP) and Trifluoperazine (TFP), on mammary tumor cells, osteoclasts, osteoblasts, and osteocytes. These agents suppressed proliferation and migration of mammary tumor cells chiefly by antagonizing dopamine receptor D2 and reduced bone resorption by downregulating nuclear factor of activated T-cells, cytoplasmic 1 (Nfatc1)...
May 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29767642/regarding-the-joint-statement-from-the-american-college-of-surgeons-committee-on-trauma-acs-cot-and-the-american-college-of-emergency-physicians-acep-regarding-the-clinical-use-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa
#19
Bryant K Allen, David W Callaway, Michael Gibbs, Erin Noste, Kathryn West, M Austin Johnson, David Caro, Andy Godwin
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29764659/mechanisms-of-aphid-adaptation-to-host-plant-resistance
#20
REVIEW
Ashley D Yates, Andy Michel
Host-plant resistant (HPR) crops can play a major role in preventing insect damage, but their durability is limited due to insect adaptation. Research in basal plant resistance provides a framework to investigate adaptation against HPR. Resistance and adaptation are predicted to follow the gene-for-gene and zigzag models of plant defense. These models also highlight the importance of insect effectors, which are small molecules that modulate host plant defense signaling. We highlight research in insect adaptation to plant resistance, and then draw parallels to virulence adaptation...
April 2018: Current Opinion in Insect Science
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