Zhao Yin, Yiwen Lv, Li Deng, Guangchao Li, Ruiming Ou, Lizhi Chen, Yangmin Zhu, Qi Zhong, Zhi Liu, Jing Huang, Hong Wu, Qing Zhang, Jia Fei, Shuang Liu
Since multiple myeloma (MM) remains a cureless malignancy of plasma cells to date, it becomes imperative to develop novel drugs and therapeutic targets for MM. We screened a small molecule library comprising 3633 natural product drugs, which demonstrated that Nitidine Chloride (NC), an extract from traditional Chinese medicine Zanthoxylum nitidum. We used Surface Plasmon Resonance-High Performance Liquid Chromatography-Protein Mass Spectrometry (SPR-HPLC-MS), Cellular Thermal Shift Assay (CETSA), molecular docking, and SPR assay to identify the potential targets of NC, in which ABCB6 was the unique target of NC...
April 10, 2023: Free Radical Biology & Medicine