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Microbiome pregnancy

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https://www.readbyqxmd.com/read/29135334/maternal-high-fat-diet-and-its-consequence-on-the-gut-microbiome-a-rat-model
#1
Phyllis E Mann, Kevin Huynh, Giovanni Widmer
The biological changes that occur during pregnancy in the female mammal include shifts in hormonal regulation in preparation for parturition and lactation, and changes in energy metabolism. In women, studies have also shown that during pregnancy there is a reduction in bacterial species richness in the gut. In the current experiment rats were used to model the interaction of diet, reproductive status, and intestinal bacterial microbiota during pregnancy and lactation. In Experiment 1 rats were exposed to either standard chow or high-fat chow (60%) and were divided into two groups: unmated (NULL) or mated (RE)...
November 14, 2017: Gut Microbes
https://www.readbyqxmd.com/read/29122491/inflammation-and-autism-from-maternal-gut-to-fetal-brain
#2
Ivan Osokine, Adrian Erlebacher
Maternal immune activation (MIA) during pregnancy is associated with an increased risk of behavioral disorders in the offspring of affected mothers. Two recent studies highlight how maternal inflammation disrupts inhibitory interneuron networks and suggest that the maternal gut microbiome may be a contributing risk factor for MIA-induced behavioral abnormalities.
November 6, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29077897/in-vivo-oxygen-temperature-and-ph-dynamics-in-the-female-reproductive-tract-and-their-importance-in-human-conception-a-systematic-review
#3
Ka Ying Bonnie Ng, Roel Mingels, Hywel Morgan, Nick Macklon, Ying Cheong
BACKGROUND: Despite advances in ART, implantation and pregnancy rates per embryo transfer still remain low. IVF laboratories strive to ensure that the process of handling gametes in vitro closely mimics the in vivo environment. However, there remains a lack of knowledge regarding the in vivo regulation and dynamic variation in biophysical parameters such as oxygen concentration, pH and temperature within the reproductive tract. OBJECTIVE AND RATIONALE: To undertake a systematic review of the current understanding of the physico-chemical parameters of oxygen tension (pO2), pH and temperature within the female reproductive tract, and their potential implications in clinical and pathological processes related to fertility and those pertaining to limited reproductive capacity...
October 25, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29069100/gut-microbiome-of-mothers-delivering-prematurely-shows-reduced-diversity-and-lower-relative-abundance-of-bifidobacterium-and-streptococcus
#4
Cecilie Dahl, Maggie Stanislawski, Nina Iszatt, Siddhartha Mandal, Catherine Lozupone, Jose C Clemente, Rob Knight, Hein Stigum, Merete Eggesbø
OBJECTIVE: Preterm birth is the main reason for neonatal deaths worldwide. We investigate whether maternal gut microbiota may play a previously overlooked role. METHODS: The Norwegian Microbiota Study (NoMIC) is a case control study on preterm birth (<259 days of gestation, calculated primarily based on the last menstrual period), including two consecutively born term infants per infant born prematurely. Eligible mothers were fluent in Norwegian and recruited from the maternity ward at a county hospital in Eastern Norway in the period 2002-2005...
2017: PloS One
https://www.readbyqxmd.com/read/29049068/the-maternal-gut-microbiome-during-pregnancy
#5
(no author information available yet)
No abstract text is available yet for this article.
November 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29042534/the-microbiota-continuum-along-the-female-reproductive-tract-and-its-relation-to-uterine-related-diseases
#6
Chen Chen, Xiaolei Song, Weixia Wei, Huanzi Zhong, Juanjuan Dai, Zhou Lan, Fei Li, Xinlei Yu, Qiang Feng, Zirong Wang, Hailiang Xie, Xiaomin Chen, Chunwei Zeng, Bo Wen, Liping Zeng, Hui Du, Huiru Tang, Changlu Xu, Yan Xia, Huihua Xia, Huanming Yang, Jian Wang, Jun Wang, Lise Madsen, Susanne Brix, Karsten Kristiansen, Xun Xu, Junhua Li, Ruifang Wu, Huijue Jia
Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of debate. Here we systematically sample the microbiota within the female reproductive tract in 110 women of reproductive age, and examine the nature of colonisation by 16S rRNA gene amplicon sequencing and cultivation. We find distinct microbial communities in cervical canal, uterus, fallopian tubes and peritoneal fluid, differing from that of the vagina...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29038841/the-maternal-microbiome-during-pregnancy-and-allergic-disease-in-the-offspring
#7
REVIEW
Peter J Vuillermin, Laurence Macia, Ralph Nanan, Mimi Lk Tang, Fiona Collier, Susanne Brix
There is substantial epidemiological and mechanistic evidence that the increase in allergic disease and asthma in many parts of the world in part relates to changes in microbial exposures and diet acting via the composition and metabolic products of the intestinal microbiome. The majority of research in this field has focused on the gut microbiome during infancy, but it is increasingly clear that the maternal microbiome during pregnancy also has a key role in preventing an allergy-prone immune phenotype in the offspring...
October 16, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29032226/maternal-depressive-symptoms-linked-to-reduced-fecal-immunoglobulin-a-concentrations-in-infants
#8
Liane J Kang, Petya T Koleva, Catherine J Field, Gerald F Giesbrecht, Eytan Wine, Allan B Becker, Piushkumar J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott, Anita L Kozyrskyj
Secretory Immunoglobulin A (sIgA) plays a critical role to infant gut mucosal immunity. Delayed IgA production is associated with greater risk of allergic disease. Murine models of stressful events during pregnancy and infancy show alterations in gut immunity and microbial composition in offspring, but little is known about the stress-microbiome-immunity pathways in humans. We investigated differences in infant fecal sIgA concentrations according to the presence of maternal depressive symptoms during and after pregnancy...
October 12, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29021375/maternal-high-fiber-diet-during-pregnancy-and-lactation-influences-regulatory-t-cell-differentiation-in-offspring-in-mice
#9
Akihito Nakajima, Naoko Kaga, Yumiko Nakanishi, Hiroshi Ohno, Junki Miyamoto, Ikuo Kimura, Shohei Hori, Takashi Sasaki, Keiichi Hiramatsu, Ko Okumura, Sachiko Miyake, Sonoko Habu, Sumio Watanabe
Short-chain fatty acids (SCFAs), the end products of dietary fiber, influence the immune system. Moreover, during pregnancy the maternal microbiome has a great impact on the development of the offspring's immune system. However, the exact mechanisms by which maternal SCFAs during pregnancy and lactation influence the immune system of offspring are not fully understood. We investigated the molecular mechanisms underlying regulatory T cell (Treg) differentiation in offspring regulated by a maternal high fiber diet (HFD)...
October 11, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29020789/-the-role-of-maternal-imunity-and-woman%C3%A2-s-microbiome-in-the-pathogenesis-of-preterm-labor
#10
M Koucký, K Malíčková, J Hrdý, A Černý, H Hrbáčková, P Šimják, A Pařízek
OBJECTIVE: To summarize available data concerning the role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor and their use in clinical practice. SETTING: Department of Obstetrics and Gynecology od the First Faculty of Medicine, Charles University in Prague, and General Teaching Hospital. DESIGN: Review article. METHODS: Compilation od published data from scientific literature. CONCLUSION: Preterm labor complicates approximately 10% of all pregnancies and represents a serious medical, social and economic problem...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28969463/meconium-microbiome-as-a-new-source-of-information-about-long-term-health-and-disease-questions-and-answers
#11
P Wilczyńska, E Skarżyńska, B Lisowska-Myjak
OBJECTIVE: To assess the diagnostic role of meconium microbiota as a source of information about the intrauterine environment of the developing fetus and possibly health and disease in later life. METHODS: The literature review of over 30 papers published in international journals in the years 2001-2017, on the bacterial composition of meconium and early feces, investigated by metagenomic DNA sequencing in experimental studies on animals and clinical studies in neonates born after normal and pathological pregnancies...
October 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28954525/clinical-relevance-of-gastrointestinal-microbiota-during-pregnancy-a-primer-for-nurses
#12
Seon-Yoon Chung, Jacques Ravel, Mary Regan
Emerging evidence about the human microbiome, a collective term for all the microorganisms living in and on the human body, consistently demonstrates the critical influence it has on host physiology and disease risk. The microbiota in the gastrointestinal (GI) tract has the most significant and far-reaching effect on human physiology. The maternal GI microbiota can decrease the risk of adverse pregnancy outcomes by modulating energy extraction, glucose metabolism, vitamin production, and host immunity essential for optimal maternal and neonatal health...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28941962/racial-and-ethnic-differences-in-preterm-birth-a-complex-multifactorial-problem
#13
REVIEW
Tracy A Manuck
Preterm birth remains the leading cause of morbidity and mortality among nonanomalous neonates, and is a major public health problem. Non-Hispanic black women have a 2-fold greater risk for preterm birth compared with non-Hispanic white race. The reasons for this disparity are poorly understood and cannot be explained solely by sociodemographic factors. Underlying factors including a complex interaction between maternal, paternal, and fetal genetics, epigenetics, the microbiome, and these sociodemographic risk factors likely underlies the differences between racial groups, but these relationships are currently poorly understood...
September 20, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28941769/a-neuro-immune-neuro-oxidative-and-neuro-nitrosative-model-of-prenatal-and-postpartum-depression
#14
REVIEW
Chutima Roomruangwong, George Anderson, Michael Berk, Drozdstoy Stoyanov, André F Carvalho, Michael Maes
A large body of evidence indicates that major affective disorders are accompanied by activated neuro-immune, neuro-oxidative and neuro-nitrosative stress (IO&NS) pathways. Postpartum depression is predicted by end of term prenatal depressive symptoms whilst a lifetime history of mood disorders appears to increase the risk for both prenatal and postpartum depression. This review provides a critical appraisal of available evidence linking IO&NS pathways to prenatal and postpartum depression. The electronic databases Google Scholar, PubMed and Scopus were sources for this narrative review focusing on keywords, including perinatal depression, (auto)immune, inflammation, oxidative, nitric oxide, nitrosative, tryptophan catabolites (TRYCATs), kynurenine, leaky gut and microbiome...
September 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28939908/microbiome-profile-of-the-amniotic-fluid-as-a-predictive-biomarker-of-perinatal-outcome
#15
Daichi Urushiyama, Wataru Suda, Eriko Ohnishi, Ryota Araki, Chihiro Kiyoshima, Masamitsu Kurakazu, Ayako Sanui, Fusanori Yotsumoto, Masaharu Murata, Kazuki Nabeshima, Shin'ichiro Yasunaga, Shigeru Saito, Makoto Nomiyama, Masahira Hattori, Shingo Miyamoto, Kenichiro Hata
Chorioamnionitis (CAM), an inflammation of the foetal membranes due to infection, is associated with preterm birth and poor perinatal prognosis. The present study aimed to determine whether CAM can be diagnosed prior to delivery based on the bacterial composition of the amniotic fluid (AF). AF samples from 79 patients were classified according to placental inflammation: Stage III (n = 32), CAM; Stage II (n = 27), chorionitis; Stage 0-I (n = 20), sub-chorionitis or no neutrophil infiltration; and normal AF in early pregnancy (n = 18)...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925412/prenatal-antimicrobial-use-and-early-childhood-body-mass-index
#16
A E Cassidy-Bushrow, C Burmeister, S Havstad, A M Levin, S V Lynch, D R Ownby, A G Rundle, K J Woodcroft, E M Zoratti, C C Johnson, G Wegienka
BACKGROUND/OBJECTIVES: Growing evidence suggests that antibiotic use is associated with childhood body mass index (BMI), potentially via mechanisms mediated by gut microbiome alterations. Less is known on the potential role of prenatal antimicrobial use in offspring obesity risk. We examined whether prenatal antibiotic or antifungal use was associated with BMI at the age of 2 years in 527 birth cohort participants. METHODS/SUBJECTS: Antimicrobial use was obtained from the prenatal medical record...
August 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28915448/the-composition-of-the-vaginal-microbiome-in-first-trimester-pregnant-women-influences-the-level-of-autophagy-and-stress-in-vaginal-epithelial-cells
#17
Dimitrios Nasioudis, Larry J Forney, G Maria Schneider, Karol Gliniewicz, Michael T France, Allison Boester, Mio Sawai, Jessica Scholl, Steven S Witkin
Epithelial cells lining the vagina are major components of genital tract immunity. The influence of the vaginal microbiome on properties of host epithelial cells is largely unexplored. We evaluated whether differences in the most abundant lactobacilli species or bacterial genera in the vagina of first trimester pregnant women were associated with variations in the extent of stress and autophagy in vaginal epithelial cells. Vaginal swabs from 154 first trimester pregnant women were analyzed for bacterial composition by amplification and sequencing of the V1-V3 region of bacterial 16S rRNA genes...
September 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28904056/simultaneously-monitoring-immune-response-and-microbial-infections-during-pregnancy-through-plasma-cfrna-sequencing
#18
Wenying Pan, Thuy T M Ngo, Joan Camunas-Soler, Chun-Xiao Song, Mark Kowarsky, Yair J Blumenfeld, Ronald J Wong, Gary M Shaw, David K Stevenson, Stephen R Quake
BACKGROUND: Plasma cell-free RNA (cfRNA) encompasses a broad spectrum of RNA species that can be derived from both human cells and microbes. Because cfRNA is fragmented and of low concentration, it has been challenging to profile its transcriptome using standard RNA-seq methods. METHODS: We assessed several recently developed RNA-seq methods on cfRNA samples. We then analyzed the dynamic changes of both the human transcriptome and the microbiome of plasma during pregnancy from 60 women...
September 13, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28894161/microbial-communities-in-placentas-from-term-normal-pregnancy-exhibit-spatially-variable-profiles
#19
Lindsay A Parnell, Catherine M Briggs, Bin Cao, Omar Delannoy-Bruno, Andrew E Schrieffer, Indira U Mysorekar
The placenta is the principal organ nurturing the fetus during pregnancy and was traditionally considered to be sterile. Recent work has suggested that the placenta harbours microbial communities, however the location and possible function of these microbes remain to be confirmed and elucidated. Here, we employed genomic DNA sequencing of multiple variable (V) regions of the bacterial 16S ribosomal gene, to interrogate microbial profiles in term pregnancies, from the basal plate, which is in direct contact with maternal uterine, endothelial, and immune cells; placental villi, which are bathed in maternal blood, and fetal membranes, which encapsulate the amniotic cavity...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886045/maternal-treatment-with-short-chain-fatty-acids-modulates-the-intestinal-microbiota-and-immunity-and-ameliorates-type-1-diabetes-in-the-offspring
#20
James C Needell, Diana Ir, Charles E Robertson, Miranda E Kroehl, Daniel N Frank, Danny Zipris
We recently hypothesized that the intestinal microbiota and the innate immune system play key roles in the mechanism of Kilham Rat Virus-induced type 1 diabetes in the LEW1.WR1 rat. We used this animal model to test the hypothesis that maternal therapy with short-chain fatty acids can modulate the intestinal microbiota and reverse virus-induced proinflammatory responses and type 1 diabetes in rat offspring. We observed that administration of short-chain fatty acids to rat breeders via drinking water prior to pregnancy and further treatment of the offspring with short-chain fatty acids after weaning led to disease amelioration...
2017: PloS One
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