Jiri Soukup, Monika Manethova, Vaclav Stejskal, Marie Novakova, Jaroslava Duskova, Helena Hornychova, Maria Hacova, Iva Staniczkova-Zambo, Tomas Zelinka, Mikulas Kosak, Tomas Cesak, David Netuka, Ales Ryska, Filip Gabalec
Hand2 is a core transcription factor responsible for chromaffin cell differentiation. However, its potential utility in surgical pathology has not been studied. Thus, we aimed to investigate its expression in paragangliomas, other neuroendocrine neoplasms (NENs), and additional non-neuroendocrine tumors. We calibrated Hand2 immunohistochemistry on adrenal medulla cells and analyzed H-scores in 46 paragangliomas (PGs), 9 metastatic PGs, 21 cauda equina neuroendocrine tumors (CENETs), 48 neuroendocrine carcinomas (NECs), 8 olfactory neuroblastomas (ONBs), 110 well-differentiated NETs (WDNETs), 10 adrenal cortical carcinomas, 29 adrenal cortical adenomas, 8 melanomas, 41 different carcinomas, and 10 gastrointestinal stromal tumors (GISTs)...
February 28, 2024: Endocrine Pathology