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Cervical cytology

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https://www.readbyqxmd.com/read/29774361/diagnostic-performance-of-ata-bta-and-tirads-sonographic-patterns-in-the-predication-of-malignancy-in-histologically-proven-thyroid-nodules
#1
Chiaw Ling Chng, Hong Chang Tan, Chow Wei Too, Wei Ying Lim, Priscilla Pei Sze Chiam, Ling Zhu, Nivedita Vikas Nadkarni, Adoree Yi Ying Lim
INTRODUCTION: We aimed to compare the malignancy risk stratification of histologically proven thyroid nodules using the 2015 American Thyroid Association (ATA) Management Guidelines, 2014 British Thyroid Association (BTA) Guidelines for the Management of Thyroid Cancer and Thyroid Imaging Reporting and Data System (TIRADS). METHODS: Thyroid nodules measuring > 1 cm resected over 5.5 years were retrospectively studied. Information like gender and age, and cytology and histopathology results were collected...
May 18, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29773301/pap-tests-in-the-diagnosis-of-cervical-cancer-help-or-hinder
#2
Lauren Philp, Nathaniel Jembere, Li Wang, Julia Gao, Bryan Maguire, Rachel Kupets
OBJECTIVE: To evaluate the impact of pap tests on the time to diagnosis of cervical cancer. METHODS: In this population-based retrospective cohort study, Ontario women ≥21 years diagnosed with cervical cancer between 2011 and 2014 were identified and database data collected. The presence or absence of a pap test 0-2 years preceding cancer diagnosis was identified. Descriptive and modelling analyses were performed to determine the effect of pap results on cancer diagnosis...
May 15, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29772366/giant-cell-ependymoma-of-cervical-medullary-junction-a-case-report-of-a-long-term-survivor-and-review-of-literature
#3
REVIEW
Martina Cappelletti, Andrea G Ruggeri, Giorgia Iacopino, Roberto Delfini
Ependymoma accounts for 3-9% of all neuroepithelial tumors. The giant cell ependymoma is a rare and distinct variant, of which only twenty-two cases have been described in literature. Starting from 2007, the WHO acknowledged this rare subtype. The cytological features of GCE are the presence of pleomorphic giant cells with several cellular atypias, which at intra-operative frozen diagnosis may appear to be high-grade glial lesions. Despite its apparently malignant histology, GCE seems to be a neoplasm with a relatively good prognosis...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29770625/risks-of-cervical-intraepithelial-neoplasia-grade-3-or-invasive-cancers-in-ascus-women-with-different-management-a-population-based-cohort-study
#4
Yi Jou Tai, Yun Yuan Chen, Huang Cheng Hsu, Chun Ju Chiang, San Lin You, Chi An Chen, Wen Fang Cheng
OBJECTIVE: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements. METHODS: Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model...
March 20, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770623/quality-of-tissue-from-punch-biopsy-forceps-vs-round-loop-electrode-in-colposcopically-directed-biopsy-a-randomized-controlled-trial
#5
Thanita Wetcho, Athithan Rattanaburi, Kanet Kanjanapradit
OBJECTIVE: To compare the quality of tissue from punch biopsy forceps (PB group) with round loop electrode (LE group) in colposcopically directed biopsy along with the evaluation of pain associated with each procedure. METHODS: Patients with abnormal cervical cytologic results and abnormal colposcopic findings were enrolled into a randomized trial into either a PB group or LE group. The quality of tissue was evaluated in regards to the size of tissue, site of tissue, and tissue damage...
March 12, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770617/the-use-of-conization-to-identify-and-treat-severe-lesions-among-prediagnosed-cin1-and-2-patients-in-japan
#6
Mikio Mikami, Masae Ikeda, Hidetaka Sato, Haruko Iwase, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi
OBJECTIVE: To evaluate the clinical efficiency of identifying patients with suspicious severe lesions by conization among prediagnosed cervical intraepithelial neoplasia (CIN) 1 and 2 patients in Japan. METHODS: The data in a Japanese nation-wide registry for cervical cancer (2009 and 2011) was collected to analyze the clinical efficacy of pre- and postdiagnosis for 13,215 Japanese women who underwent treatment by conization. Their preoperative and postoperative histologic findings and clinical outcomes were evaluated using standard statistical procedures including clinical and demographic characteristics...
March 8, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29768678/the-ideal-strategy-for-cervical-cancer-screening-in-japan-result-from-the-fukui-cervical-cancer-screening-study
#7
T Kurokawa, T Onuma, A Shinagawa, Y Chino, M Kobayashi, Y Yoshida
OBJECTIVE: The aims of the Fukui Cervical Cancer Screening (FCCS) study are to determine the frequency of women with high-risk HPV (hrHPV), whether HPV16 or HPV18 (HPV16/18), in the Japanese cancer screening population for the first time and to identify the best strategy for cervical cancer screening in Japan. METHODS: This study enrolled 7,584 women ≥25 years of age who were undergoing routine screening. All women underwent liquid-based cytology and cobas HPV tests...
May 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29767914/impact-of-applying-a-learning-strategy-to-improve-the-sample-quality-in-cervical-screening-in-nursing-staff-in-social-service
#8
Sandra Olimpia Gutiérrez Enríquez, Luis Fernando Méndez Donjuan, Yolanda Terán Figueroa, Darío Gaytán Hernández, Cuauhtémoc Oros Ovalle, Aracely Díaz Oviedo
OBJECTIVES: The study sought to assess the impact of applying a learning strategy to improve the quality of sample collection during cervical screening by students from the Nursing Degree Program doing social service. METHODS: This was a longitudinal, quasi-experimental study with the participation of 23 interns from the Nursing Degree Program at a public university from San Luis Potosí, Mexico. The work assessed knowledge of practical skills in taking cervical cytology tests and the quality of samples before and after applying a learning strategy that included 10 h of theoretical training and 22 h of practices on themes related to sample collection in cervical screening...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29764400/low-cost-hpv-testing-and-the-prevalence-of-cervical-infection-in-asymptomatic-populations-in-guatemala
#9
Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales, Victor Argueta, Andert Rosingh, Femke J H B van Aerde-van Nunen, Griselda Lopez, Herbert M Pinedo, Mark Schiffman, Michael Dean, Roberto Orozco
BACKGROUND: A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determine the most prevalent HPV types and the distribution of HPV infections in over 1795 cancer-free women in Guatemala undergoing primary screening for cervical cancer by cytology...
May 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29764329/preliminary-results-of-the-first-cervical-cancer-screening-programme-in-the-north-eastern-region-of-romania
#10
Ioana Păvăleanu, Dumitru Gafiţanu, Nicolae Ioanid, Mihaela Grigore
Objective Cervical cancer represents a major health problem in Romania. A national population-based cervical cancer screening programme was launched in 2012. The aims of the study were to assess the participation rate and to estimate the prevalence of epithelial cell abnormalities in the first four years of the programme in North Eastern Romania. Methods The participation rate, representing the proportion of eligible women screened in the programme, was evaluated for 2012-2016. The prevalence of cytological abnormalities was estimated by age group and calendar year...
January 1, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29762164/cervical-cancer-screening-among-hiv-infected-women-in-an-urban-u-s-safety-net-healthcare-system
#11
Arti Barnes, Andrea C Betts, Eric K Borton, Joanne M Sanders, Sandi L Pruitt, Claudia Werner, Andres Bran, Carolee D Estelle, Bijal A Balasubramanian, Stephen J Inrig, Ethan A Halm, Celette Sugg Skinner, Jasmin A Tiro
OBJECTIVE: Little is known about cervical cancer screening and results patterns among HIV infected (HIV+) women in real-world healthcare settings. We characterized two periods of screening opportunity. DESIGN: Retrospective cohort. SETTING: U.S. safety-net healthcare system in Dallas County, Texas. SUBJECTS: We analyzed data from electronic medical records (EMR) of 1,490 HIV+ women receiving care 2010-2014. MAIN OUTCOME MEASURES: At baseline, we categorized a woman's Pap status 15 months prior to index date as under-screened (vs...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29758205/performance-of-p16-ki67-dual-staining-in-triaging-hr-hpv-positive-population-during-cervical-cancer-screening-in-the-younger-women
#12
Qiu-Ping Qian, Xiaoan Zhang, Bo Ding, Shi-Wen Jiang, Ze-Min Li, Mu-Lan Ren, Yang Shen
BACKGROUND: Cervical cancer is the most common malignancy from the female reproductive tract, and usually develops from low-grade or high-grade squamous intraepithelial lesions (LSIL or HSIL). Detecting the precancerous lesion during the LSIL-HSIL-invasive cancer sequelae can effectively interrupt the oncogenesis and decrease the incidence of invasive carcinoma. The aim of this study is to evaluate the performance of P16/Ki67 dual staining in triaging hr-HPV-positive population. METHODS: Conventional gynecological examination, cervical cytology and hr-HPV testing were given to all patients...
May 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29752912/association-between-viral-loads-of-different-oncogenic-human-papillomavirus-types-and-the-degree-of-cervical-lesions-in-the-progression-of-cervical-cancer
#13
Wei Wang, Xian-Hui Zhang, Mei Li, Chong-Hua Hao, Zhi-Min Zhao, Hong-Ping Liang
OBJECTIVE: In this study we determined the frequency of the most prevalent human papillomavirus (HPV) types in China and evaluated the association between viral loads of different oncogenic HPV types and the severity of disease. METHODS: We enrolled 15,518 women for this study and 3199 of them (20.61%) were identified as positive by a PCR assay, that can simultaneously quantify and genotype HPV. RESULTS: The viral loads of HPV 16, 31, 35, 52, 58, 39, and 56 were lower for women with normal cytology compared to those with disease progression; viral loads were not appreciable for HPV 33, 18, 45, 59, 68, 53, 66, and 51...
May 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29750702/morphologic-features-of-gastric-type-cervical-adenocarcinoma-in-small-surgical-and-cytology-specimens
#14
Gulisa Turashvili, Elizabeth G Morency, Mihaela Kracun, Deborah F DeLair, Sarah Chiang, Robert A Soslow, Kay J Park, Rajmohan Murali
Gastric-type cervical adenocarcinoma (GCA) is a human papillomavirus-unassociated, aggressive, chemorefractory tumor. Well-differentiated examples may exhibit bland morphologic appearances, which could potentially lead to misdiagnosis, particularly in limited material. We sought to characterize the morphologic features of GCA in surgical biopsy and cytology specimens. We identified patients with histologic diagnoses of GCA or minimal-deviation adenocarcinoma between 2004 and 2017. Available slides from biopsy, curettage, and cytology specimens were reviewed...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29747337/-comparison-of-screening-performance-between-primary-high-risk-hpv-screening-and-high-risk-hpv-screening-plus-liquid-based-cytology-cotesting-in-diagnosis-of-cervical-precancerous-or-cancerous-lesions
#15
X L Zhao, Rezhake Remila, S Y Hu, L Zhang, X Q Xu, F Chen, Q J Pan, X Zhang, F H Zhao
Objective: To evaluate and compare the screening performance of primary high-risk HPV(HR-HPV) screening and HR-HPV screening plus liquid-based cytology (LBC) cotesting in diagnosis of cervical cancer and precancerous lesions (CIN2+). Methods: We pooled 17 population-based cross-sectional studies which were conducted across China from 1999 to 2008. After obtaining informed consent, all women received liquid-based cytology(LBC)testing, HR-HPV DNA testing. Totally 28 777 women with complete LBC, HPV and biopsy results were included in the final analysis...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29746625/extended-human-papillomavirus-genotype-distribution-and-cervical-cytology-results-in-a-large-cohort-of-chinese-women-with-invasive-cervical-cancers-and-high-grade-squamous-intraepithelial-lesions
#16
Wei Jiang, R Marshall Austin, Lei Li, Kaixuan Yang, Chengquan Zhao
Objectives: To study the human papillomavirus (HPV) genotype distribution of cervical cancer (CxCa) and cervical intraepithelial neoplasia grade 2/3 (CIN2/3) in China and to evaluate cotesting of HPV and cytology in CxCa screening. Methods: Patients with histopathologic CxCa and CIN 2/3 diagnoses reported between January 2012 and June 2016 and extended HPV genotype testing in the prior 6 months were documented in the institute. Available prior Papanicolaou (Pap) test results were also documented...
April 16, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29746541/demonstration-of-an-algorithm-to-overcome-health-system-related-barriers-to-timely-diagnosis-of-breast-diseases-in-rural-zambia
#17
Leeya F Pinder, Jean-Baptiste Nzayisenga, Aaron Shibemba, Victor Kusweje, Hector Chiboola, Mary Amuyunzu-Nyamongo, Sharon Kapambwe, Catherine Mwaba, Pavlo Lermontov, Chibamba Mumba, Ronda Henry-Tillman, Groesbeck P Parham
BACKGROUND: Long delays to diagnosis is a major cause of late presentation of breast diseases in sub-Saharan Africa. AIMS: We designed and implemented a single-visit breast care algorithm that overcomes health system-related barriers to timely diagnosis of breast diseases. METHODS: A multidisciplinary team of Zambian healthcare experts trained a team of mid- and high-level Zambian healthcare practitioners how to evaluate women for breast diseases, and train trainers to do likewise...
2018: PloS One
https://www.readbyqxmd.com/read/29739098/comparison-of-a-newly-developed-hpv-genotyping-assay-mojin-hpv-kit-with-cobas-4800-hpv-test-for-detection-of-high-risk-hpv-in-specimens-collected-in-surepath-solution
#18
Wan-Wei Yang, Zhi-Guo Wang, Guo-Fang Chen, Jian-Feng Shi, Juan Chen, Quan-Hui Ma, Jing Zhou, Xiao-Dong Mao, Chao Liu, Xiao-Ming Yao
BACKGROUND: Human papillomavirus (HPV) detection based on cervical cytology specimens is useful for cervical cancer screening. The aim of this study was to compare Mojin HPV kit (a newly developed HPV genotyping assay) with the Cobas 4800 HPV test in detecting high-risk (HR) HPV. METHODS: A total of 347 cervical exfoliated cell specimens were tested using the Mojin HPV kit and Cobas 4800 HPV test. When the results from the two tests were inconsistent, gene sequencing was performed for correction...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736316/hpv16-viral-load-and-physical-state-measurement-as-a-potential-immediate-triage-strategy-for-hr-hpv-infected-women-a-study-in-644-women-with-single-hpv16-infections
#19
Anna Manawapat-Klopfer, Lisa Wang, Juliane Haedicke-Jarboui, Frank Stubenrauch, Christian Munk, Louise T Thomsen, Peter Martus, Susanne K Kjaer, Thomas Iftner
High genome copy number (viral load) of human papillomavirus (HPV) is being discussed as a risk factor for high-grade cervical lesions. However, conflicting data about the integration status or viral load of the virus as risk factors for prevalent high-grade squamous intraepithelial lesions (HSIL) are found in the literature. To investigate whether viral load and/or integration status are indicative for prevalent ASCUS/LSIL or HSIL, we determined the HPV16 viral load and the physical state of the genome in 644 women with single HPV16 infections stratified by their cytology results from a large Danish population-based cohort consisting of 40,399 women...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29734247/clinical-and-economic-value-of-p16ink4a-for-the-differential-diagnosis-of-morphologic-cervical-intraepithelial-neoplasia-2
#20
Vanina S Fishkel, Fernando C Monge, Felicitas M von Petery, Karen E Tapper, Teresa M Peña, Florencia Torres, Fernando A Poletta, Jorge F Elgart, Alejandra Avagnina, Valeria Denninghoff
The detection of high-grade intraepithelial lesions requires highly sensitive and specific methods that allow more accurate diagnoses. This contributes to a proper management of preneoplastic lesions, thus avoiding overtreatment. The purpose of this study was to analyze the value of immunostaining for p16 in the morphologic assessment of cervical intraepithelial neoplasia 2 lesions, to help differentiate between low-grade (p16-negative) and high-grade (p16-positive) squamous intraepithelial lesions. The direct medical cost of the treatment of cervical intraepithelial neoplasia 2 morphologic lesions was estimated...
May 4, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
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