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Cervical cytology

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https://www.readbyqxmd.com/read/28937367/associations-between-epidermal-growth-factor-receptor-and-topoisomerase-ii-alpha-gene-copy-number-variations-human-papillomavirus-positivity-and-cytologic-analysis-in-cervical-cell-lesions
#1
Işın Kaya, Oya Nermin Sivrikoz, Özdal Etlik, Abdülkadir Gök
BACKGROUND: Cervical cancer is the second most common gynecologic cancer worldwide. Human papillomavirus (HPV) infection is a leading etiological factor in cervical carcinoma.The aim of this study was to compare HPV positivity, EGFR and TOP2A gene copy number variations and cervical cytologic findings. MATERIALS AND METHODS: The study group comprised 100 female volunteers between 21-64 years old. Cytologic analysis was performed using the liquid-based cytology technique...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28934992/breast-cancer-metastases-to-the-thyroid-gland-an-uncommon-sentinel-for-diffuse-metastatic-disease-a-case-report-and-review-of-the-literature
#2
Agata M Plonczak, Aimee N DiMarco, Roberto Dina, Dorothy J Gujral, Fausto F Palazzo
BACKGROUND: Metastases to the thyroid are rare. The most common primary cancer to metastasize to the thyroid is renal cell carcinoma, followed by malignancies of the gastrointestinal tract, lungs, and skin, with breast cancer metastases to the thyroid being rare. Overall, the outcomes in malignancies that have metastasized to the thyroid are poor. There are no prospective studies addressing the role of surgery in metastatic disease of the thyroid. Isolated thyroidectomy has been proposed as a local disease control option to palliate and prevent the potential morbidity of tumor extension related to the airway...
September 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28931234/the-evva-cohort-study-anal-and-cervical-type-specific-human-papillomavirus-prevalence-persistence-and-cytologic-findings-in-women-living-with-hiv
#3
Alexandra de Pokomandy, Elaina Kaufman, Christina de Castro, Marie-Hélène Mayrand, Ann N Burchell, Marina Klein, Louise Charest, Manon Auger, Sophie Rodrigues-Coutlée, François Coutlée
Background: The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in women living with human immunodeficiency virus (HIV) than in the general population. We present findings of cervical and anal HPV and cytologic tests at baseline in the EVVA cohort study and HPV persistence data 6 months after baseline. Methods: Semiannual visits included questionnaires, chart reviews, cervical/anal cytologic and cervical/anal HPV testing for 2 years...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28926579/cervical-screening-with-primary-hpv-testing-or-cytology-in-a-population-of-women-in-which-those-aged-33-years-or-younger-had-previously-been-offered-hpv-vaccination-results-of-the-compass-pilot-randomised-trial
#4
Karen Canfell, Michael Caruana, Val Gebski, Jessica Darlington-Brown, Stella Heley, Julia Brotherton, Dorota Gertig, Chloe J Jennett, Annabelle Farnsworth, Jeffrey Tan, C David Wrede, Philip E Castle, Marion Saville
BACKGROUND: Using primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population (by 2014, resident women ≤33 years had been age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%-77%)...
September 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28923423/burden-of-hpv-caused-cancers-in-denmark-and-the-potential-effect-of-hpv-vaccination
#5
Malene Skorstengaard, Lise Holst Thamsborg, Elsebeth Lynge
BACKGROUND: Denmark is one of the countries where Human papillomavirus (HPV)-vaccination at present includes only girls. However, the burden of HPV-related cancer in men is increasing, which would argue for gender-neutral vaccination. The aim of this study was to examine the burden of HPV-caused cancers in women and men, and to evaluate the potential of HPV-vaccination in cancer control. METHODS: Data were retrieved from the literature on population prevalence of high risk (HR) HPV, on HR HPV-prevalence and genotypes in HPV-related cancers, and on number of cytology samples in cervical screening...
September 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28923300/influence-of-co-infection-complicated-with-human-papillomavirus-on-cervical-intraepithelial-neoplasia-development-in-patients-with-atypical-squamous-cells-of-undetermined-significance
#6
Hisami Kiseki, Yutaka Tsukahara, Natsumi Tajima, Ayako Tanaka, Aya Horimoto, Naohiko Hashimura
AIM: Human papillomaviruses (HPV) infection is a primary cause of the development of cervical precancerous lesions and cervical cancer. However, the influence of other infections on intraepithelial neoplasia (CIN) development has not been fully elucidated. We evaluated the association between co-infection and CIN development in subjects with atypical squamous cells of undetermined significance (ASCUS). METHOD: Data for ASCUS subjects who had undergone testing for high risk HPV (HR-HPV) and pathological diagnosis were analyzed...
September 8, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28919602/comparative-study-of-cytology-and-histopathology-of-cervical-lesion-in-via-positive-patients-and-its-correlation-with-high-risk-human-papilloma-virus
#7
N P Ansari, F M Saleh, S M Shahida, E N Rahman
Cervical cancer is the second most frequent type of cancer and leading cause of mortality among women worldwide. The present study was undertaken to assess precancerous and cancerous cervical lesion by cytology as well as HPV DNA identification and their comparison with histopathology in VIA positive cases. This descriptive, cross-sectional type of observational study was carried out in the Department of Pathology, Mymensingh Medical College in collaboration with the Department of Gynecology and Obstetrics, Mymensingh Medical College Hospital and Department of Microbiology and Hygiene in Bangladesh Agriculture University for HPV DNA detection from July 2012 to June 2013...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28918430/distribution-of-chlamydia-trachomatis-genotypes-in-infective-diseases-of-the-female-lower-genital-tract
#8
Yujie Chen, Jing Chen, Lan Yang, Yanming Jiang, Li Li, Wenjuan Yi, Lifang Lan, Liuhong Zhang
The purpose of this study was to investigate the distribution of Chlamydia trachomatis (CT) genotypes in infective diseases of the female lower genital tract, especially in cervical diseases. This study included 128 CT-positive women. DNA was extracted from cervical swabs. Omp1 gene PCR-RFLP and sequencing were used to confirm the subtypes of CT. The association of subtypes with age, clinical symptoms, cervical cytology, and biopsy results was further analyzed. Omp1 gene PCR-RFLP and sequencing showed that the order of prevalent CT genotypes in the female lower genital tract was D (n=38, 29...
September 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28918099/role-of-hpv-dna-testing-in-modern-gynaecological-practice
#9
REVIEW
Guglielmo Ronco, Paolo Giorgi Rossi
The identification of some types of human papillomavirus (HPV) as necessary, but not sufficient, cause of cervical cancer has suggested the use of HPV testing in cervical cancer prevention. A large number of studies has provided evidence supporting its application (1) as primary screening test, (2) for triaging borderline cytology, (3) for follow-up after positive primary test but no abnormal histology and (4) as a test of cure. They also allowed a reasonably good definition of the appropriate policies and protocols, leading to the delivery of evidence-based guidelines resulting from a systematic review of the literature...
August 12, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28916509/risk-prediction-of-cervical-cancer-and-precancers-by-type-specific-human-papillomavirus-%C3%A2-evidence-from-a-population-based-cohort-study-in-china
#10
Li Dong, Shang-Ying Hu, Qian Zhang, Ruimei Feng, Li Zhang, Xuelian Zhao, Xun Zhang, Fang-Hui Zhao, You-Lin Qiao
Risk stratification of human papillomavirus (HPV)-positive women is needed to avoid excessive colposcopy and overtreatment in cervical cancer screening. We aimed to evaluate the predictive value of type-specific HPV in detecting cervical cancer and precancers in a Chinese population-based cohort and provide evidence of HPV genotyping to triage HPV-positive women. We typed all Hybrid Capture 2-positive cytological samples of 1,742 women in Shanxi Province Cervical Cancer Screening Study cohort. Cumulative risks of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) among HPV positive women and cumulative detection rates of CIN2+ among general women by type-specific HPV were estimated during the course of ten-year follow-up...
September 15, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28913693/human-papillomavirus-genotype-distribution-in-cervical-samples-among-vaccine-na%C3%A3-ve-barbados-women
#11
Juann M Ward, Kolin Schmalenberg, Nick A Antonishyn, Ian R Hambleton, Elizabeth L Blackman, Paul N Levett, Marquita V Gittens-St Hilaire
PURPOSE: This study was undertaken to provide baseline HPV genotype distribution among women in Barbados before HPV immunization was introduced. This information would then be used as a denominator for post-vaccine surveillance and is expected to aid in understanding the effect of vaccination on cervical disease in Barbados. METHODS: Liquid-based cytology specimens were collected from 413 women (age range 18-65 years) attending three clinics, in a pre-vaccination, population-based study...
September 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28913135/prognostic-risk-factors-for-lymph-node-involvement-in-patients-with-endometrial-cancer
#12
Tayfun Toptaş, Tayup Şimşek, Şeyda Karaveli
OBJECTIVE: We aimed to analyze variables affecting lymph node (LN) involvement and to assess the need for systematic lymphadenectomy in patients with endometrial cancer (EC). MATERIALS AND METHODS: A single centre retrospective analysis was conducted in a total of 128 consecutive patients with EC who underwent systematic pelvic or combined pelvic and paraaortic lymphadenectomy between 2009 and 2012. Mann-Whitney U, chi-square, and Fisher's exact test were used for univariate analyses when appropriate...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28910940/-diagnostic-value-of-p16-mcm2-dual-staining-in-cervical-intraepithelial-neoplasia-and-its-association-with-high-risk-hpv-infection
#13
H R Wang, G D Liao, Y Jiang, Y C Li, Y L Qiao, W Chen
Objective: To study the expression of p16/mcm2 immunocytochemical dual staining in cervical lesions and its association with high-risk HPV infection, and discuss its clinical value in cervical cancer screening. Methods: From May to December 2015, a total of 1 127 women receiving cervical cancer screening, high-risk HPV (HR-HPV) test and liquid-based cytology test were included in the study. p16/mcm2 immunocytochemical dual staining was performed on residual cytology specimens and the results were compared with histopathology results...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28905520/vaginal-enterobius-vermicularis-diagnosed-on-liquid-based-cytology-during-papanicolaou-test-cervical-cancer-screening-a-report-of-two-cases-and-a-review-of-the-literature
#14
Chun-Yi Tsai, Rachel Junod, Martine Jacot-Guillarmod, Charles Beniere, Sonia Ziadi, Massimo Bongiovanni
Enterobiasis is one of the most common human parasitic infections. It is considered an intestinal parasite, but cases of extra-intestinal affections exist, notably infections of the female genital tract. Enterobius vermicularis (EV) eggs (or ova) have been found in the cervical smears of two patients in our institute during the last 16 years. No gynaecological or gastrointestinal symptoms were reported, and there was no known intestinal infection in these two cases. A review of the available literature revealed rare cases of vaginal enterobiasis, with a wide range of clinical presentations, many patients being asymptomatic...
September 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28903730/routine-monitoring-and-assessment-of-adults-living-with-hiv-results-of-the-british-hiv-association-bhiva-national-audit-2015
#15
A Molloy, H Curtis, F Burns, A Freedman
BACKGROUND: The clinical care of people living with HIV changed fundamentally as a result of the development of effective antiretroviral therapy (ART). HIV infection is now a long-term treatable condition. We report a national audit to assess adherence to British HIV Association guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals. METHODS: All UK sites known as providers of adult HIV outpatient services were invited to complete a case-note review and a brief survey of local clinic practices...
September 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28902073/cryotherapy-reduces-progression-of-cervical-intraepithelial-neoplasia-grade-1-in-south-african-hiv-infected-women-a-randomized-controlled-trial
#16
Cynthia Firnhaber, Avril Swarts, Bridgette Goeieman, Ntombi Rakhombe, Masangu Mulongo, Anna-Lise Williamson, Pam Michelow, Sibongile Ramotshela, Mark Faesen, Simon Levin, Timothy Wilkin
BACKGROUND: HIV-infected women are at increased risk of cervical cancer, especially in resource-limited countries. Cervical cancer prevention strategies focus treating cervical high-grade squamous intraepithelial lesions (HSIL). The management of low-grade squamous intraepithelial lesions (LSIL) in HIV-infected women is unknown. SETTING: HIV treatment clinic in Johannesburg, South Africa METHODS:: We randomized HIV-infected women with histologic cervical LSIL to cervical cryotherapy vs...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28901682/referral-population-studies-underestimate-differences-between-human-papillomavirus-assays-in-primary-cervical-screening
#17
M Rebolj, S Njor, E Lynge, S Preisler, D Ejegod, C Rygaard, J Bonde
OBJECTIVE: We studied how representative cytologically abnormal women ("referral populations") are with respect to uncovering differences between human papillomavirus (HPV) assays in the primary screening where most women are cytologically normal. METHODS: A total of 4997 women were tested with SurePath® cytology, and Hybrid Capture 2 (HC2), cobas, CLART and APTIMA HPV assays. Women with positive test results were offered a follow-up. For all detected HPV infections and HPV-positive high-grade cervical intraepithelial neoplasia (≥CIN2), we studied the distributions of assay-specific signal strengths in the baseline samples as documented by the assays' automatically generated reports...
October 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28901302/the-clinical-application-of-hpv-e6-e7-mrna-testing-in-triaging-women-with-atypical-squamous-cells-of-undetermined-significance-or-low-grade-squamous-intra-epithelial-lesion-pap-smear-a-meta-analysis
#18
REVIEW
Li Yang, Yuanhang Zhu, Yang Bai, Xiaoan Zhang, Chenchen Ren
OBJECTIVE: The aim is to evaluate the clinical application value and correlation with cervical lesions' progression of human papillomavirus (HPV) E6/E7 mRNA test in women with atypical squamous cells of undetermined significance (ASCUS/borderline) or low-grade squamous intraepithelial lesions (LSILs/mild dyskaryosis) cytological abnormalities. METHODS: A meta-analysis was conduct by searching China National Knowledge Infrastructure (1979-2016), Wanfang Date (1998-2016), VIP (1989-2016), PubMed (1950-2016), Web of Science (1950-2016) and Elsevier Science Direct (1998-2016), for studies on effect of HPV E6/E7 mRNA detection in women with ASCUS/LSIL/dyskaryosis...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28900610/the-role-of-intraoperative-thyroglobuline-level-of-lymph-node-in-the-management-of-papillary-thyroid-cancer-determination-of-a-cutoff-point
#19
Mohsen Kolahdouzan, Mehdi Sadeghi, Behrooz Kalidari, Behnam Sanei, Elyas Mostafapour, Ashraf Aminorroaya
BACKGROUND: Some studies have shown that a preoperative high concentration of thyroglobulin (Tg) in wash out of fine-needle aspiration cytology of cervical lymph nodes mandate therapeutic lymph node dissection. However, there is disagreement about the minimum concentration of Tg which could have diagnostic value. Hence, according to our literature review, this study is the first one which designed to do intraoperatively. Therefore, this study was conducted and aimed to determine the clinical diagnostic value of Tg lymph nodes in the diagnosis of metastatic thyroid cancer...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28900480/hpv-test-results-and-histological-follow-up-results-of-patients-with-lsil-cervical-cytology-from-the-largest-cap-certified-laboratory-in-china
#20
Baowen Zheng, Huaitao Yang, Zaibo Li, Guijian Wei, Jia You, Xiaoman Liang, Chengquan Zhao
BACKGROUND: Age-adjusted evaluations have explored the possible utility of (HPV test results in women with LSIL Pap. We investigated HPV test results and histopathologic follow-up results of LSIL patients from China's largest CAP-certified laboratory. METHODS: Patients with LSIL between 2011 and 2015 from the Guangzhou Kingmed Diagnostics were retrospectively retrieved and their hrHPV test results and histological follow-up results were collected and analyzed. RESULTS: LSIL result was identified in 37,895 cases from 2,206,588 Pap tests (1...
2017: Journal of Cancer
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