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Cervical cytology

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https://www.readbyqxmd.com/read/28432169/primary-malignant-melanoma-of-the-cervix-a-rare-disease
#1
Ivo Julião, Sonia Dias Carvalho, Vanda Patricio, Ana Raimundo
Malignant melanoma (MM) arising primarily in the cervix is exceedingly rare and has a poor prognosis. We report the case of a primary MM of the cervix in a 64-year-old woman with vaginal bleeding. She presented with a cervical amelanotic lesion which on biopsy rendered the diagnosis of MM. The patient was staged as International Federation of Gynecology and Obstetrics IIB and underwent Wertheim-Meigshysterectomy followed by brachytherapy. One year later, she was diagnosed with a large pelvic relapse for which surgery was performed...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28431571/unique-lcr-variations-among-lineages-of-hpv16-18-and-45-isolates-from-women-with-normal-cervical-cytology-in-ghana
#2
Adolf K Awua, Richard M K Adanu, Edwin K Wiredu, Edwin A Afari, Vanessa A Zubuch, Richard H Asmah, Alberto Severini
BACKGROUND: In addition to being useful for classification, sequence variations of human Papillomavirus (HPV) genotypes have been implicated in differential oncogenic potential and a differential association with the different histological forms of invasive cervical cancer. These associations have also been indicated for HPV genotype lineages and sub-lineages. In order to better understand the potential implications of lineage variation in the occurrence of cervical cancers in Ghana, we studied the lineages of the three most prevalent HPV genotypes among women with normal cytology as baseline to further studies...
April 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28431558/epidemiology-and-genotype-distribution-of-human-papillomavirus-hpv-in-southwest-china-a-cross-sectional-five-years-study-in-non-vaccinated-women
#3
Yishu Tang, Lan Zheng, Shuangshuang Yang, Bing Li, Huiting Su, Li-Ping Zhang
BACKGROUND: Large-size data on type-specific HPV prevalence in Southwest China are required to estimate the cervical cancer burden in the country and to prepare for HPV-based cervical screening program and further HPV vaccination of China. This HPV study is a pooled analysis of data from five years in Chongqing of China, which is cross-sectional in design using data collecting. RESULTS: The positivity of HPV was 26.2% (10542/40311), single type was 25.7% (10360/40311), multiple type was 8...
April 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28431303/circular-shape-constrained-fuzzy-clustering-ciscfc-for-nucleus-segmentation-in-pap-smear-images
#4
Ratna Saha, Mariusz Bajger, Gobert Lee
Accurate detection and segmentation of cell nucleus is the precursor step towards computer aided analysis of Pap smear images. This is a challenging and complex task due to degree of overlap, inconsistent staining and poor contrast. In this paper, a novel nucleus segmentation method is proposed by incorporating a circular shape function in fuzzy clustering. The proposed method was evaluated quantitatively and qualitatively using the Overlapping Cervical Cytology Image Segmentation Challenge - ISBI 2014 challenge dataset comprised of 945 overlapping Pap smear images...
April 14, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28427086/self-sampling-to-improve-cervical-cancer-screening-coverage-in-switzerland-a-randomised-controlled-trial
#5
Manuela Viviano, Rosa Catarino, Emilien Jeannot, Michel Boulvain, Manuela Undurraga Malinverno, Pierre Vassilakos, Patrick Petignat
BACKGROUND: The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland. METHODS: Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25-69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG)...
April 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28426837/the-high-prevalence-of-hpv-and-hpv16-european-variants-in-cervical-and-anal-samples-of-hiv-seropositive-women-with-normal-pap-test-results
#6
Lays Paula Bondi Volpini, Neide Aparecida Tosato Boldrini, Luciana Bueno de Freitas, Angelica Espinosa Miranda, Liliana Cruz Spano
Human Immunodeficiency Virus (HIV)-seropositive women are more likely to have anogenital cancer, and high risk-HPV (HR-HPV) infection is the main associated factor. Between August 2013 and December 2015, we conducted a descriptive study to determine the HPV genotypes and HPV16 variants in cervical and anal samples of HIV-seropositive women with a normal Pap test. The viral DNA was amplified by PCR using the PGMY09/11 set of primers. Reverse line blot (RLB), restriction fragment length polymorphism (RFLP) and sequencing assays were used to determine the HPV genotypes...
2017: PloS One
https://www.readbyqxmd.com/read/28418208/accuracy-of-self-collected-human-papillomavirus-samples-from-japanese-women-with-abnormal-cervical-cytology
#7
Kawano-Yashiro Aiko, Motoki Yoko, Oba Mari Saito, Asano Ryoko, Maruyama Yasuyo, Asai-Sato Mikiko, Yamanaka Takeharu, Hirahara Fumiki, Miyagi Etsuko
AIM: The aim of this study was to assess the accuracy of self-collected vaginal samples compared with physician-collected cervical samples for high-risk human papillomavirus (HPV) testing in Japanese women with abnormal cervical cytology. We also assessed the acceptability of self-collected HPV (sHPV) testing using a questionnaire. METHODS: Women aged 20-69 years (n = 136) attending Yokohama City University Hospital because of abnormal cervical cytology between April 2014 and January 2015 were enrolled in this study...
April 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28415708/human-papillomavirus-subtypes-distribution-among-2309-cervical-cancer-patients-in-west-china
#8
Kemin Li, Rutie Yin, Danqing Wang, Qingli Li
OBJECTIVE: The prevalence of cervical Human Papillomavirus (HPV) infection in cervical cancer varies greatly worldwide, and HPV prevalence and genotypes in China are limited. The objective is to analyze the prevalence of HPV subtypes in cervical cancer patients in west China as well as the relationships between different histological types of cervical cancer and HPV subtypes. RESULTS: 2309 cases were included. 90.86% were infected with HPV, and the remaining 9.13% were negative...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415159/comparison-of-unsatisfactory-samples-from-conventional-smear-versus-liquid-based-cytology-in-uterine-cervical-cancer-screening-test
#9
Hoiseon Jeong, Sung Ran Hong, Seoung-Wan Chae, So-Young Jin, Hye Kyoung Yoon, Juhie Lee, Eun Kyung Kim, Sook Tai Ha, Sung Nam Kim, Eun-Jung Park, Jong Jae Jung, Sun Hee Sung, Sung-Chul Lim
Background: Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories. Materials and Methods: Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis...
April 17, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28413396/mammary-analogue-secretory-carcinoma-presenting-as-a-cervical-lymph-node-metastasis-of-unknown-primary-site-a-case-report
#10
Kensuke Suzuki, Masao Yagi, Akira Kanda, Yoshiki Kobayashi, Masaya Konishi, Chika Miyasaka, Takashi Tashiro, Hiroshi Iwai
BACKGROUND: Mammary analogue secretory carcinoma (MASC) is a pathological entity arising in the salivary glands first described by Skalova et al. [Am J Surg Pathol 2010;34: 599-608]. Here, we report the first case of MASC presenting as a cervical lymph node metastasis of unknown primary site together with a brief review of the literature. CASE REPORT: We present a 74-year-old male with a painless lump in his left neck. Based on the fine-needle aspiration cytological findings, a possible malignant tumor was suspected...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28411397/chondrosarcoma-like-metastasis-from-a-poorly-differentiated-uterine-cervical-squamous-cell-carcinoma-a-unique-morphology-and-diagnostic-pitfall-in-cytology
#11
Shohei Ikoma, Marlo Nicolas, Jaishree Jagirdar, Maria Luisa Policarpio-Nicolas
Rare cases of metastatic squamous cell carcinoma with chondroid differentiation from esophageal primary have been reported but none from the uterine cervix. Given the rarity of this phenomenon and potential diagnostic pitfall, we present this unusual case. The patient is a 25-year-old woman who presented with shortness of breath. Computerized tomography (CT) showed several lung and pleural-based nodules. CT-guided core biopsy with touch preparations were performed on the pleural-based nodule. The touch preparations showed large, spindle-to-oval shaped cells with pleomorphic nuclei embedded in metachromatic chondroid stroma...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28409676/analysis-of-risk-factors-for-persistent-infection-of-asymptomatic-women-with-high-risk-human-papilloma-virus
#12
Nianmin Shi, Qiang Lu, Jiao Zhang, Li Li, Junnan Zhang, Fanglei Zhang, Yanhong Dong, Xinyue Zhang, Zheng Zhang
OBJECTIVE: This study aims to prevent persistent infection, reduce the incidence of cervical cancer, and improve women's health by understanding the theoretical basis of the risk factors for continuous infection of asymptomatic women with high-risk human papilloma virus (HPV) strains via information collected, which includes the persistent infection rate and the most prevalent HPV strain types of high risk to asymptomatic women in the high-risk area of cervical cancer in Linfen, Shanxi Province...
April 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28404931/a-retrospective-analysis-of-the-utility-of-endocervical-curettage-in-screening-population
#13
Yan Song, Yu-Qian Zhao, Ling Li, Qin-Jin Pan, Nan Li, Fang-Hui Zhao, Wen Chen, Xun Zhang, You-Lin Qiao
The performance of endocervical curettage (ECC) is a dispute in population screening programs. Data of 3,460 women referred to colposcopy examination and had completed pathological results in the Shanxi Province Cervical Cancer Screening Study I and II were reviewed. Among them, 0.6% and 2.7% women were identified as the histopathological confirmed high-grade squamous intraepithelial lesion or worse (HSIL+) by ECC alone or both ECC and quadrants biopsy respectively. Age, cytology, and colposcopy impression are the impact factors for the HSIL+ yield of ECC (P<0...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404551/endocervical-gastric-type-adenocarcinoma-an-unrelated-hpv-tumour-difficulties-in-screening-and-diagnosis
#14
Priscila Carneiro Lima, Julio Teixeira, Guilherme Nogueira Aires, Liliana De Angelo Andrade
Gastric-type adenocarcinoma of the cervix (GAS) is an uncommon and aggressive tumour unrelated to human papillomavirus (HPV) infection with distinctive histological and immunohistochemical characteristics. GAS may be associated with lobular endocervical glandular hyperplasia (LEGH), another unusual lesion. We report a case of a 59-year-old woman with screening cytology 'AGC-Neo' and cervical conisation exhibiting cervical intraepithelial neoplasia grade 1, extensive LEGH and canal sampling with abundant mucinous cells...
April 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28403024/multimodal-hyperspectroscopic-imaging-for-detection-of-high-grade-cervical-intraepithelial-neoplasia
#15
Renée M F Ebisch, Marjolein Hermens, Petronella A J van den Akker, Leon F A G Massuger, Willem J G Melchers, Ruud L M Bekkers
OBJECTIVE: Numerous new alternative digital colposcopy techniques have been developed, of which multimodal hyperspectroscopy (MHS) showed a high sensitivity in previous studies. The objective of this prospective single-center cohort study was to evaluate the clinical value of MHS for detecting high-grade cervical intraepithelial neoplasia in a colposcopy referral population and colposcopy follow-up population, to assess whether MHS could be safely used to improve care for women at risk for high-grade cervical intraepithelial neoplasia...
April 11, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28399532/metastatic-pituitary-carcinoma-to-cervical-lymph-node-diagnosis-by-fine-needle-aspiration-and-review-of-the-literature
#16
Huiying Wang, Jiancong Liang, William H Yong, Peggy Sullivan
BACKGROUND: Pituitary carcinomas are rare neoplasms whose designation requires demonstration of metastatic disease. No specific morphologic features can reliably distinguish pituitary carcinomas from pituitary adenomas, rendering the diagnosis particularly challenging. Furthermore, as reports of pituitary carcinoma on fine needle aspiration (FNA) biopsy are exceedingly rare in the literature, the cytological features of pituitary carcinoma are poorly characterized. CASE REPORT: Here we describe a case of pituitary carcinoma in a 67-year-old woman with history of recurrent adrenocorticotropic hormone (ACTH)-producing pituitary adenoma who presented with a persistent left cervical nodule for 2 years...
April 12, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28397203/comparison-of-the-diagnostic-value-of-cervical-cytology-and-hpv-hr-dna-testing-for-the-diagnosis-of-low-grade-and-high-grade-squamous-intraepithelial-lesions-across-different-age-groups
#17
Aleksandra Paluszkiewicz, Dominik Pruski, Kinga Iwaniec, Witold Kędzia
OBJECTIVES: To assess the diagnostic value of cervical cytology and HPV HR DNA testing for the diagnosis of low grade and high-grade squamous intraepithelial lesions across different age groups. MATERIAL AND METHODS: The study included 1103 patients, age 25-70 years. All patients underwent in-depth diagnostic tests following either an abnormal Pap test result or a clinically suspicious cervical lesion. In all women the following examinations were performed: a molecular test detecting 14 high-risk types of HPV, a colposcopy examination, as well as directed-biopsy of the cervix...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28393061/nasopharyngeal-carcinoma-with-cystic-cervical-metastasis-masquerading-as-branchial-cleft-cyst-a-potential-pitfall-in-diagnosis-and-management
#18
Lum Sai-Guan, Kong Min-Han, Ngan Kah-Wai, Mohd-Razif Mohamad-Yunus
INTRODUCTION: Most metastatic lymph nodes from head and neck malignancy are solid. Cystic nodes are found in 33% - 61% of carcinomas arise from Waldeyer's ring, of which only 1.8% - 8% originate are from the nasopharynx. Some cystic cervical metastases were initially presumed to be branchial cleft cyst. This case report aims to highlight the unusual presentation of cystic cervical metastasis secondary to nasopharyngeal carcinoma in a young adult. The histopathology, radiological features and management strategy were discussed...
March 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28392582/does-cin2-have-the-same-aggressive-potential-as-cin3-a-secondary-analysis-of-high-grade-cytology-recurrence-in-women-treated-with-cold-coagulation-cervical-treatment
#19
D Papoutsis, M Underwood, W Parry-Smith, J Panikkar
Introduction To determine whether women with CIN2 versus CIN3 on pretreatment cervical punch biopsy have less high-grade cytology recurrence following cold-coagulation cervical treatment. Materials and Methods This was a retrospective study of women having had cold coagulation between 2001-2011 in our colposcopy unit. Women with previous cervical treatment were excluded. Results We identified 402 women with 260 (64.7 %) cases of CIN2 and 142 (35.3 %) cases of CIN3 on pretreatment cervical punch biopsy. In the total sample, the mean age of women was 27...
March 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28391730/impact-of-different-educational-interventions-on-psychosocial-well-being-of-women-with-a-positive-high-risk-human-papillomavirus-and-normal-cervical-cytology-a-randomised-trial
#20
Siew Fei Ngu, Na Wei, Tracy T C Kwan, Mandy M Y Chu, Ka Yu Tse, Karen K L Chan, Hextan Y S Ngan
INTRODUCTION: The aim of this study was to compare the effect of two educational interventions on the psychosocial well-being of Hong Kong Chinese women who have a positive high-risk human papillomavirus (HPV) test and normal cervical cytology. METHODS: Participants were randomised into either leaflet group, in which a written HPV factsheet was provided; or counselling group, in which a didactic HPV presentation in person in addition to the factsheet was provided...
April 10, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
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