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https://www.readbyqxmd.com/read/29345294/hypoxia-stimulates-the-cytoplasmic-localization-of-oncogenic-long-noncoding-rna-linc00152-in-colorectal-cancer
#1
Yujiro Nishizawa, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Norikatsu Miyoshi, Hidekazu Takahashi, Naohiro Nishida, Naotsugu Haraguchi, Daisuke Sakai, Toshihiro Kudo, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Recent studies have indicated that long noncoding RNAs (lncRNAs) play a pivotal role in almost all physiological cellular processes, including every stage of cancer development. Given that hypoxia in the tumor microenvironment is involved in the malignant behavior of tumors, such as invasion and metastasis, we investigated the cytoplasmic and nuclear localization of lncRNAs in colorectal cancer cells. A cell culture under hypoxic conditions revealed several lncRNAs, such as LINC00152, whose levels were increased in the cytoplasm of colorectal cancer cells...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29344431/noncoding-rnas-in-wound-healing-a-new-and-vast-frontier
#2
REVIEW
Anna Luan, Michael S Hu, Tripp Leavitt, Elizabeth A Brett, Kevin C Wang, Michael T Longaker, Derrick C Wan
Significance: Wound healing requires a highly orchestrated coordination of processes that are not yet fully understood. Therefore, available clinical therapies are thus far limited in their efficacy in preventing and treating both chronic wounds and scars. Current gene-based therapeutics is largely based on our understanding of the protein-coding genome and proteins involved in known wound healing pathways. Recent Advances: Noncoding RNAs such as microRNAs and long noncoding RNAs have recently been found to be significant modulators of gene expression in diverse cellular pathways...
January 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29344285/long-noncoding-rna-h19-derived-mir-675-regulates-cell-proliferation-by-down-regulating-e2f-1-in-human-pancreatic-ductal-adenocarcinoma
#3
Ling Ma, Xiaodong Tian, Huahu Guo, Zhengkui Zhang, Chong Du, Feng Wang, Xuehai Xie, Hongqiao Gao, Yan Zhuang, Marko Kornmann, Hong Gao, Yinmo Yang
The long noncoding RNA (lncRNA) H19 has been proven to be overexpressed in human pancreatic ductal adenocarcinoma (PDAC). H19-induced PDAC cell proliferation is cell cycle-dependent by modulating E2F-1. However, the mechanism of how H19 regulates E2F-1 remains unclear. In this study, we investigated the expression of miR-675 in PDAC tumours and cells, the biological function of miR-675 in PDAC cell proliferation and the possible relationship among H19, miR-675 and E2F-1. As a transcript of the first exon of H19, the level of miR-675 was negatively correlated with H19 expression in microdissected PDAC tissues (r=-0...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29343207/genome-wide-analysis-identified-a-number-of-dysregulated-long-noncoding-rna-lncrna-in-human-pancreatic-ductal-adenocarcinoma
#4
Sijie Hao, Lie Yao, Jiaxin Huang, Hang He, Feng Yang, Yang Di, Chen Jin, Deliang Fu
BACKGROUND: Long noncoding RNAs have been shown to play crucial roles in cancer biology, while the long noncoding RNA landscapes of pancreatic ductal adenocarcinoma have not been completely characterized. We aimed to determine whether long noncoding RNA could serve as early diagnostic biomarkers for pancreatic ductal adenocarcinoma. METHOD: We conducted a genome-wide microarray analysis on pancreatic ductal adenocarcinoma and their adjacent noncancerous tissues from 8 Chinese patients...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29343005/-role-of-long-noncoding-rna-in-chronic-hepatitis-b-infection
#5
M Zhao, Z Z Zhang, Q B Liu
No abstract text is available yet for this article.
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29341928/a-novel-brown-adipocyte-enriched-long-non-coding-rna-that-is-required-for-brown-adipocyte-differentiation-and-sufficient-to-drive-thermogenic-gene-program-in-white-adipocytes
#6
Yan Xiong, Feng Yue, Zhihao Jia, Yun Gao, Wen Jin, Keping Hu, Yong Zhang, Dahai Zhu, Gongshe Yang, Shihuan Kuang
The thermogenic activities of brown and beige adipocytes can be exploited to reduce energy surplus and counteract obesity. Recent RNA sequencing studies have uncovered a number of long noncoding RNAs (lncRNAs) uniquely expressed in white and brown adipose tissues (WAT and BAT), but whether and how these lncRNAs function in adipogenesis remain largely unknown. Here, we report the identification of a novel brown adipocyte-enriched LncRNA (AK079912), and its nuclear localization, function and regulation. The expression of AK079912 increases during brown preadipocyte differentiation and in response to cold-stimulated browning of white adipocytes...
January 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29340250/integrated-genomic-analyses-of-lung-squamous-cell-carcinoma-for-identification-of-a-possible-competitive-endogenous-rna-network-by-means-of-tcga-datasets
#7
Pengbo Ning, Zhongxing Wu, Aoxue Hu, Xuepeng Li, Jun He, Xiaocheng Gong, Yuqiong Xia, Yukui Shang, Huijie Bian
The etiology of cancer includes aberrant cellular homeostasis where a compromised RNA regulatory network is a prominent contributing factor. In particular, noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were recently shown to play important roles in the initiation, progression, and metastasis of human cancers. Nonetheless, a mechanistic understanding of noncoding RNA functions in lung squamous cell carcinoma (LUSC) is lacking. To fill this critical gap in knowledge, we obtained mRNA, miRNA, and lncRNA expression data on patients with LUSC from the updated Cancer Genome Atlas (TCGA) database (2016)...
2018: PeerJ
https://www.readbyqxmd.com/read/29340026/evaluating-the-bias-of-circrna-predictions-from-total-rna-seq-data
#8
Jinzeng Wang, Kang Liu, Ya Liu, Qi Lv, Fan Zhang, Haiyun Wang
CircRNAs are a group of endogenous noncoding RNAs. The quickly developing high throughput RNA sequencing technologies along with novel bioinformatics approaches have enabled researchers to systematically identify circRNAs and their biological functions in cells. Deep sequencing of rRNA-depleted RNAs treated with RNase R, which digests linear RNAs and leaves circRNAs enriched, is an efficient way to identify circRNAs. However, very few of RNase R treated data are at hand but a large amount of total RNA-Seq data with no sequencing costs is available, for circRNA predictions...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29336373/advances-of-long-noncoding-rnas-mediated-regulation-in-reproduction
#9
REVIEW
Kang-Sheng Liu, Tai-Ping Li, Hua Ton, Xiao-Dong Mao, Ya-Jun Chen
OBJECTIVE: Advances in genomics and molecular biology have led to the discovery of a large group of uncharacterized long noncoding RNAs (lncRNAs). Emerging evidence indicated that many lncRNAs function in multiple biological processes and its dysregulation often causes diseases. Recent studies suggested that almost all regulatory lncRNAs interact with biological macromolecules such as DNA, RNA, and protein. LncRNAs regulate gene expression mainly on three levels, including epigenetic modification, transcription, and posttranscription, through DNA methylation, histone modification, and chromatin remodeling...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29335535/a-multi-omics-study-of-the-grapevine-downy-mildew-plasmopara-viticola-pathosystem-unveils-a-complex-protein-coding-and-noncoding-based-arms-race-during-infection
#10
Matteo Brilli, Elisa Asquini, Mirko Moser, Pier Luigi Bianchedi, Michele Perazzolli, Azeddine Si-Ammour
Fungicides are applied intensively to prevent downy mildew infections of grapevines (Vitis vinifera) with high impact on the environment. In order to develop alternative strategies we sequenced the genome of the oomycete pathogen Plasmopara viticola causing this disease. We show that it derives from a Phytophthora-like ancestor that switched to obligate biotrophy by losing genes involved in nitrogen metabolism and γ-Aminobutyric acid catabolism. By combining multiple omics approaches we characterized the pathosystem and identified a RxLR effector that trigger an immune response in the wild species V...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335281/high-throughput-identification-of-rna-nuclear-enrichment-sequences
#11
Chinmay J Shukla, Alexandra L McCorkindale, Chiara Gerhardinger, Keegan D Korthauer, Moran N Cabili, David M Shechner, Rafael A Irizarry, Philipp G Maass, John L Rinn
In the post-genomic era, thousands of putative noncoding regulatory regions have been identified, such as enhancers, promoters, long noncoding RNAs (lncRNAs), and a cadre of small peptides. These ever-growing catalogs require high-throughput assays to test their functionality at scale. Massively parallel reporter assays have greatly enhanced the understanding of noncoding DNA elements en masse Here, we present a massively parallel RNA assay (MPRNA) that can assay 10,000 or more RNA segments for RNA-based functionality...
January 15, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29334272/extracellular-vesicle-mimetic-nanovesicles-transport-lncrna-h19-as-competing-endogenous-rna-for-the-treatment-of-diabetic-wounds
#12
Shi-Cong Tao, Bi-Yu Rui, Qi-Yang Wang, Ding Zhou, Yang Zhang, Shang-Chun Guo
Diabetic wounds, one of the most enervating complications of diabetes mellitus, affect millions of people worldwide annually. Vascular insufficiency, caused by hyperglycemia, is one of the primary causes and categories of diabetic impaired wound healing. Recently, long noncoding RNA (LncRNA)-H19, which is significantly decreased in diabetes and may be crucial in triggering angiogenesis, has attracted increasing interest. The possible relationship between the decrease of LncRNA-H19 and the impairment of angiogenesis in diabetes could involve impairment of the insulin-phosphatidylinositol 3-kinase (PI3K)-Akt pathway via the interdiction of LncRNA-H19...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29332545/long-noncoding-rna-h19-inhibits-cell-viability-migration-and-invasion-via-downregulation-of-irs-1-in-thyroid-cancer-cells
#13
Peng Wang, Guoqing Liu, Weimin Xu, Haixia Liu, Qingao Bu, Diwen Sun
Thyroid cancer is a common endocrine gland malignancy which exhibited rapid increased incidence worldwide in recent decades. This study was aimed to investigate the role of long noncoding RNA H19 in thyroid cancer. Long noncoding RNA H19 was overexpressed or knockdown in thyroid cancer cells SW579 and TPC-1, and the expression of long noncoding RNA H19 was detected by real-time polymerase chain reaction. The cell viability, migration, and invasion were determined by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide assay, Transwell assay, and wound healing assay, respectively...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331759/astragaloside-iv-inhibits-cell-migration-and-viability-of-hepatocellular-carcinoma-cells-via-suppressing-long-noncoding-rna-atb
#14
Yaling Li, Yun Ye, Hongyan Chen
Astragaloside IV (AS-IV), the major active component of Astragalus membranaceus, has shown attractive anticancer effects in certain cancers. However, the roles and action mechanisms of AS-IV in hepatocellular carcinoma (HCC) are largely unclear. Long noncoding RNAs (lncRNAs) are recently revealed to have crucial roles in HCC initiation and progression, but whether lncRNAs participate in the anticancer roles of AS-IV are unknown. In this study, we demonstrated that AS-IV significantly downregulated lncRNA-ATB expression in a dose- and time-dependent manner in HCC cells...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29329543/stat3-induced-lncrna-haglros-overexpression-contributes-to-the-malignant-progression-of-gastric-cancer-cells-via-mtor-signal-mediated-inhibition-of-autophagy
#15
Jin-Fei Chen, Peng Wu, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De, Fen Yang
BACKGROUND: Long noncoding RNAs (lncRNAs) are an important class of functional regulators involved in human cancers development, including gastric cancer (GC). Studying aberrantly expressed lncRNAs may provide us with new insights into the occurrence and development of gastric cancer by acting as oncogenes or tumor suppressors. In this study, we aim to examine the expression pattern of lncRNA HAGLROS in GC and its clinical significance as well as its biological role in tumor progression...
January 12, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29329159/overexpression-of-the-long-noncoding-rna-homeboxa-transcript-at-the-distal-tip-predicts-poor-prognosis-in-a-kras-independent-manner-in-periampullary-region-tumors
#16
Ozkan Balcin, Secil Ak Aksoy, Berrin Tunca, Ekrem Kaya, Unal Egeli, Gulcin Tezcan, Nesrin Ugras, Gulsah Cecener, Ozgen Isik, Halit Ziya Dundar, Omer Yerci
OBJECTIVES: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29328783/signaling-to-and-from-the-rna-polymerase-iii-transcription-and-processing-machinery
#17
Ian M Willis, Robyn D Moir
RNA polymerase (Pol) III has a specialized role in transcribing the most abundant RNAs in eukaryotic cells, transfer RNAs (tRNAs), along with other ubiquitous small noncoding RNAs, many of which have functions related to the ribosome and protein synthesis. The high energetic cost of producing these RNAs and their central role in protein synthesis underlie the robust regulation of Pol III transcription in response to nutrients and stress by growth regulatory pathways. Downstream of Pol III, signaling impacts posttranscriptional processes affecting tRNA function in translation and tRNA cleavage into smaller fragments that are increasingly attributed with novel cellular activities...
January 12, 2018: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/29327503/noncoding-rnas-in-alzheimer-s-disease
#18
REVIEW
M Laura Idda, Rachel Munk, Kotb Abdelmohsen, Myriam Gorospe
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Despite intense efforts to develop drugs for preventing and treating AD, no effective therapies are available as yet, posing a growing burden at the personal, medical, and socioeconomic levels. AD is characterized by the production and aggregation of amyloid β (Aβ) peptides derived from amyloid precursor protein (APP), the presence of hyperphosphorylated microtubule-associated protein Tau (MAPT), and chronic inflammation leading to neuronal loss...
January 12, 2018: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/29325627/epigenetic-mechanisms-underlying-nervous-system-diseases
#19
Irfan A Qureshi, Mark F Mehler
Epigenetic mechanisms act as control systems for modulating genomic structure and activity in response to evolving profiles of cell-extrinsic, cell-cell, and cell-intrinsic signals. These dynamic processes are responsible for mediating cell- and tissue-specific gene expression and function and gene-gene and gene-environmental interactions. The major epigenetic mechanisms include DNA methylation and hydroxymethylation; histone protein posttranslational modifications, nucleosome remodeling/repositioning, and higher-order chromatin reorganization; noncoding RNA regulation; and RNA editing...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29325141/lncmap-pan-cancer-atlas-of-long-noncoding-rna-mediated-transcriptional-network-perturbations
#20
Yongsheng Li, Lili Li, Zishan Wang, Tao Pan, Nidhi Sahni, Xiyun Jin, Guangjuan Wang, Junyi Li, Xiangyi Zheng, Yunpeng Zhang, Juan Xu, Song Yi, Xia Li
Gene regulatory network perturbations contribute to the development and progression of cancer, however, molecular determinants that mediate transcriptional perturbations remain a fundamental challenge for cancer biology. We show that transcriptional perturbations are widely mediated by long noncoding RNAs (lncRNAs) via integration of genome-wide transcriptional regulation with paired lncRNA and gene expression profiles. Systematic construction of an LncRNA Modulator Atlas in Pan-cancer (LncMAP) reveals distinct types of lncRNA regulatory molecules, which are expressed in multiple tissues, exhibit higher conservation...
January 9, 2018: Nucleic Acids Research
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