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https://www.readbyqxmd.com/read/27669307/photodynamic-therapy-in-gynecologic-malignancies-a-review-of-the-roswell-park-cancer-institute-experience
#1
REVIEW
Paul C Mayor, Shashikant Lele
Photodynamic therapy (PDT) is a treatment modality used in the management of solid tumor malignancies that employs the use of a photosensitizing agent, a light source and oxygen in order to illicit a direct cytotoxic effect. Its use in gynecologic malignancies is somewhat novel and has been used for palliative and curative intent. At the Roswell Park Cancer Institute, the use of PDT in the management of gynecologic cancers began in the mid 1980s and since that time 35 patients have received PDT as a treatment for recurrent or metastatic cutaneous and vulvar, vaginal, anal, and cervical recurrences...
September 23, 2016: Cancers
https://www.readbyqxmd.com/read/26878369/porcine-xenograft-treatment-of-superficial-partial-thickness-burns-in-paediatric-patients
#2
B Burkey, W Davis, P M Glat
OBJECTIVE: Porcine xenograft (PX) has become a valuable part of the armamentarium of treatment options in a US paediatric burn centre. The use in adult patients has been well described in the burn literature, but there is minimal literature describing its use in children. The objective of this article is to describe a three-years' experience with PX use in paediatric burns. METHOD: A retrospective medical record review of patients with superficial partial-thickness burns treated with PX admitted to a paediatric burn centre between February 2009 and November 2012...
February 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/26198721/use-of-a-copolymer-dressing-on-superficial-and-partial-thickness-burns-in-a-paediatric-population
#3
M Everett, S Massand, W Davis, B Burkey, P M Glat
OBJECTIVE: Despite extensive research into the treatment of partial-thickness burns, to date there has not been the emergence of a preeminent modality. This pilot study, the first such study to be performed in a burn unit in the US, was designed to evaluate the efficacy and outcomes of the application of copolymer dressing (Suprathel; PolyMedics Innovations Corporation, Stuttgart, Germany) for both superficial and deeper partial-thickness burns. METHOD: The copolymer dressing was used as a primary wound dressing to treat superficial and deep partial-thickness burns (average 5% total body surface area) in paediatric patients...
July 2015: Journal of Wound Care
https://www.readbyqxmd.com/read/26192735/subcutaneous-injection-of-percocet-a-case-of-severe-soft-tissue-loss
#4
Sean M Baskin, Christine Abboud, Wendy Chen, Eric Tolchin, Robert W Kelly, Ariel M Aballay
Prescription drug abuse ranks as the second most common class of illicit drug use in the United States, and one mechanism of opiate abuse involves intravenous injection of enteral narcotics such as oxycodone or hydrocodone. The authors describe a patient who sustained significant soft tissue necrosis after intravenously injecting a solution made from crushed enteral narcotics, with a focus on the operative course that resulted due to a delay in initial definitive treatment. The patient's wounds encompassed 8% total body surface area and covered 247 cm2...
July 2015: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/26030934/clinical-evaluation-of-a-silver-impregnated-foam-dressing-in-paediatric-partial-thickness-burns
#5
P M Glat, S H Zhang, B A Burkey, W J Davis
OBJECTIVE: MepilexAg, a silver-impregnated foam dressing, was introduced to our institution in 2007 and our outcomes in the treatment of paediatric burns were observed to improve significantly. In order to confirm these observations, we wanted to evaluate the results of using the silver-impregnated foam dressing in partial-thickness paediatric burns.Method: In this retrospective, study, the St. Christopher's Hospital burn registry was used to identify subjects, who were otherwise in excellent health at baseline, over an 18-month period,...
April 2015: Journal of Wound Care
https://www.readbyqxmd.com/read/25853563/clinical-evaluation-of-a-silver-impregnated-foam-dressing-in-paediatric-partial-thickness-burns
#6
P M Glat, S-H Zhang, B A Burkey, W J Davis
OBJECTIVE: Mepilex Ag, a silver-impregnated foam dressing, was introduced to our institution in 2007 and our outcomes in the treatment of paediatric burns were observed to improve significantly. In order to confirm these observations, we wanted to evaluate the results of using the silver-impregnated foam dressing in partial-thickness paediatric burns. METHOD: In this retrospective study, the St. Christopher's Hospital burn registry was used to identify subjects, who were otherwise in excellent health at baseline, over an18-month period...
April 2015: Journal of Wound Care
https://www.readbyqxmd.com/read/25794216/patients-with-refractory-back-pain-treated-in-the-emergency-department-is-immediate-interlaminar-epidural-steroid-injection-superior-to-hospital-admission-and-standard-medical-pain-management
#7
COMPARATIVE STUDY
Todd Miller, Judah Burns, Jeffrey Gilligan, Francis Baffour, Allan Brook
BACKGROUND: Hospital admissions for back pain are prolonged, costly, and common. Epidural steroid injections are frequently performed in an outpatient setting with an excellent safety and efficacy profile. OBJECTIVES: The purpose was to review data from patients with severe pain that did not respond to aggressive medical treatment in the emergency department (ED) and determine the effectiveness of an interlaminar epidural steroid injection (ESI) in this patient population...
March 2015: Pain Physician
https://www.readbyqxmd.com/read/25730540/a-prospective-randomized-trial-comparing-silver-sulfadiazine-cream-with-a-water-soluble-polyantimicrobial-gel-in-partial-thickness-burn-wounds
#8
RANDOMIZED CONTROLLED TRIAL
Jonathan S Black, David B Drake
The lipid base of silver sulfadiazine (SSD) makes removal of the product painful for the patient and difficult for the physician to accurately assess particularly in partial-thickness burn injuries. As an alternative, a water-soluble antimicrobial gel is used at the University of Virginia. We present a prospective, randomized comparison of these two therapies using pain with dressing changes and time to perform dressing changes as our primary endpoints. Adult inpatients with partial-thickness burn wounds were randomized to begin therapy with either SSD cream or the water-soluble burn wound gel (BWG), and then therapies were alternated daily...
January 2015: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/25664406/improving-comfort-and-throughput-for-patients-undergoing-fractionated-laser-ablation-of-symptomatic-burn-scars
#9
Renee E Edkins, C Scott Hultman, Paul Collins, Bruce Cairns, Marilyn Hanson, Margaret Carman
INTRODUCTION: Utilization of fractionated ablation with a carbon dioxide (CO2) laser has shown to be efficacious in the management of symptomatic burn scars. Although effective, this procedure is painful and burn patients traditionally evidence low pain tolerance. For this reason intravenous anesthesia is used during these procedures. However, operative anesthetics and intravenous opioids are associated with patient discomfort postoperatively and prolonged recovery times. The American Society of Anesthesiologists' (ASA) Task Force on Acute Pain Management for the perioperative setting recommends the use of multimodal anesthesia, including the use of regional blockade with a local anesthetic...
March 2015: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/25615513/serotonin-syndrome-caused-by-fentanyl-and-methadone-in-a-burn-injury
#10
Ashley D Hillman, Corey J Witenko, Said M Sultan, Gary Gala
Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery. Serotonin syndrome may be provoked with the addition or increase in serotonergic agents such as selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, tricyclic antidepressants, and monoamine oxidase inhibitors as well as other agents with serotonergic properties...
January 2015: Pharmacotherapy
https://www.readbyqxmd.com/read/24952804/negative-pressure-dressing-assisted-healing-in-pediatric-burn-patients
#11
Shannon Koehler, Anne Jinbo, Sidney Johnson, Devin Puapong, Carl de Los Reyes, Russell Woo
BACKGROUND/PURPOSE: Pediatric burn patients traditionally require multiple dressing changes and significant amounts of narcotics. Negative pressure dressings (NPDs) have emerged as an effective wound therapy that may represent an alternative primary dressing for these patients. METHODS: This is a single institution, retrospective study of pediatric burn patients treated with NPDs over a defined 2 year period. Twenty-two patients were identified and their charts reviewed for age, sex, mode of injury, location of injury, degree of burn, length of stay, length of dressing required, number of dressing changes, and narcotic use between dressing changes...
July 2014: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/24784904/exposure-to-an-iridium-192-source-in-an-industrial-safety-worker
#12
REVIEW
Tonya C George, Todd F Huzar, James M Cross
Radiation burn injuries account for 0.2% of burn injury admissions. Treatment of radiation burns remains challenging because of unpredictable inflammatory changes and soft tissue necrosis. Conventional treatment consists of multistaged surgical procedures. Here, we present a case of an Iridium-192 exposure treated nonoperatively. A 23-year-old man presented with a 7-day-old, less than 1% TBSA radiation burn to his right hand. He initially sought treatment at an outside hospital and plastic surgeon's office postinjury days 2 and 3...
May 2014: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/24159906/stigmatization-of-substance-use-disorders-among-internal-medicine-residents
#13
Ellen C Meltzer, Alexandra Suppes, Sam Burns, Andrew Shuman, Alex Orfanos, Christopher V Sturiano, Pamela Charney, Joseph J Fins
BACKGROUND: Evidence suggests that some physicians harbor negative attitudes towards patients with substance use disorders (SUDs). The study sought to (1) measure internal medicine residents' attitudes towards patients with SUDs and other conditions; (2) determine whether demographic factors influence regard for patients with SUDs; and (3) assess the efficacy of a 10-hour addiction medicine course for improving attitudes among a subset of residents. METHODS: A prospective cohort study of 128 internal medicine residents at an academic medical center in New York City...
2013: Substance Abuse
https://www.readbyqxmd.com/read/24140586/passiflora-incarnata-l-ethnopharmacology-clinical-application-safety-and-evaluation-of-clinical-trials
#14
REVIEW
M Miroddi, G Calapai, M Navarra, P L Minciullo, S Gangemi
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Passiflora incarnata Linnaeus comprises approximately 520 species belonging to the Passifloraceae family. The majority of these species are vines found in Central or South America, with rare occurrence in North America, Southeast Asia and Australia. The genus Passiflora incarnata has long been used in traditional herbal medicine for the treatment of insomnia and anxiety in Europe, and it has been used as a sedative tea in North America. Furthermore, this plant has been used for analgesic, anti-spasmodic, anti-asthmatic, wormicidal and sedative purposes in Brazil; as a sedative and narcotic in Iraq; and for the treatment of disorders such as dysmenorrhoea, epilepsy, insomnia, neurosis and neuralgia in Turkey...
December 12, 2013: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/24134543/the-implementation-and-evaluation-of-an-evidence-based-statewide-prehospital-pain-management-protocol-developed-using-the-national-prehospital-evidence-based-guideline-model-process-for-emergency-medical-services
#15
Kathleen M Brown, Jon Mark Hirshon, Richard Alcorta, Tasmeen S Weik, Ben Lawner, Shiu Ho, Joseph L Wright
BACKGROUND: In 2008, the National Highway Traffic Safety Administration funded the development of a model process for the development and implementation of evidence-based guidelines (EBGs) for emergency medical services (EMS). We report on the implementation and evaluation of an evidence-based prehospital pain management protocol developed using this model process. METHODS: An evidence-based protocol for prehospital management of pain resulting from injuries and burns was reviewed by the Protocol Review Committee (PRC) of the Maryland Institute for Emergency Medical Services Systems (MIEMSS)...
2014: Prehospital Emergency Care
https://www.readbyqxmd.com/read/23877147/use-of-methylnaltrexone-to-induce-laxation-in-acutely-injured-patients-with-burns-and-necrotizing-soft-tissue-infections
#16
Kelly Hewitt, Hsin Lin, Iris Faraklas, Stephen Morris, Amalia Cochran, Jeffrey Saffle
The routine use of high-dose opioids for analgesia in patients with acute burns and soft-tissue injuries often leads to the development of opioid-induced constipation. The opioid antagonist methylnaltrexone (MLTX) reverses narcotic-related ileus without affecting systemic pain treatment. The authors' burn center developed a bowel protocol that included administration of MLTX for relief of opioid-induced constipation after other methods failed. The authors performed a retrospective review of patients with acute burns or necrotizing soft-tissue infections, who had been given subcutaneous MLTX to induce laxation...
March 2014: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/23542755/-new-data-for-the-pathomechanism-of-neuropathic-pain-therapeutic-evidences
#17
REVIEW
Janos Tajti, Delia Szok, László Vécsei
The present work is based on literature data from PubMed. Neuropathic pain is caused by a lesion or disease of the somatosensory system. Peripheral and central sensitization play a crucial role in its pathomechanism. The clinical symptoms are mainly characterized by burning and throbbing pain and sensory disturbances like hyperalgesia and allodynia. Therapeutic recommendations are antidepressants, antiepileptics, opioids and neuro-stimulation methods.
March 2013: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/23008958/-the-detection-of-amphetamines-in-urine-samples-using-immunochromatographic-test-strips
#18
I A Shanin, O Iu Khan, A E Petukhov, A V Smirnov, S A Eremin
This study has demonstrated the possibility of using immunochromatographic test strips for the reliable qualitative detection of amphetamine and methamphetamine in the urine samples at a cut-off level of 300 ng/ml. The test strips obtained from different manufactures are shown to be slightly different in terms of specificity as appears from the frequency of cross-reactions with various pharmaceutical products and narcotic drugs. Also, the use of the immunochromatographic strips makes it possible to determine amphetamine in a range of concentrations from 100 to 1000 ng/ml by measuring the intensity of test-line colour with the help of a TotalLab TL120 programmer and special scanning programs...
July 2012: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/22413412/ocular-injuries-from-shake-and-bake-methamphetamine-labs
#19
Annie Y Chan, Scott A Storck, Donald U Stone
PURPOSE: To review ocular injuries resulting from "shake and bake" methamphetamine labs. METHOD: Retrospective case series of 4 patients with ocular injuries sustained from "shake and bake" lab explosions. RESULTS: Four men ages 20-39 underwent complete ophthalmologic examination after an injury from a "shake and bake" methamphetamine lab explosion.The mechanism of injury was initially misrepresented in each case; the physical findings were suggestive of thermal and alkali injury...
November 2011: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/22337161/what-do-plasma-beta-endorphin-levels-reveal-about-endogenous-opioid-analgesic-function
#20
RANDOMIZED CONTROLLED TRIAL
S Bruehl, J W Burns, O Y Chung, M Chont
Plasma levels of beta-endorphin (BE), an endogenous opioid analgesic, are often reported as they relate to acute and chronic pain outcomes. However, little is known about what resting plasma BE levels might reveal about functioning of the endogenous opioid antinociceptive system. This study directly examined associations between resting plasma BE and subsequent endogenous opioid analgesic responses to acute pain in 39 healthy controls and 37 individuals with chronic low back pain (LBP). Resting baseline levels of plasma BE were assessed...
March 2012: European Journal of Pain: EJP
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