Dong Sun Oh, Eunha Kim, Guangqing Lu, Rachelly Normand, Lydia L Shook, Amanda Lyall, Olyvia Jasset, Stepan Demidkin, Emily Gilbert, Joon Kim, Babatunde Akinwunmi, Jessica Tantivit, Alice Tirard, Benjamin Y Arnold, Kamil Slowikowski, Marcia B Goldberg, Michael R Filbin, Nir Hacohen, Long H Nguyen, Andrew T Chan, Xu G Yu, Jonathan Z Li, Lael Yonker, Alessio Fasano, Roy H Perlis, Ofer Pasternak, Kathryn J Gray, Gloria B Choi, David A Drew, Pritha Sen, Alexandra-Chloé Villani, Andrea G Edlow, Jun R Huh
Pregnancy is a risk factor for increased severity of SARS-CoV-2 and other respiratory infections. The mechanisms underlying this risk have not been well-established, partly due to a limited understanding of how pregnancy shapes immune responses. To gain insight into the role of pregnancy in modulating immune responses at steady state and upon perturbation, we collected peripheral blood mononuclear cells (PBMC), plasma, and stool from 226 women, including 152 pregnant individuals (n = 96 with SARS-CoV-2 infection and n = 56 healthy controls) and 74 non-pregnant women (n = 55 with SARS-CoV-2 and n = 19 healthy controls)...
February 7, 2024: medRxiv