keyword
https://read.qxmd.com/read/38432261/amylovis-201-enhances-physiological-memory-formation-and-rescues-memory-and-hippocampal-cell-loss-in-a-streptozotocin-induced-alzheimer-s-disease-animal-model
#21
JOURNAL ARTICLE
Daymara Mercerón-Martínez, Laura Alacán Ricardo, Arturo Bejerano Pina, Norma Orama Rojo, Ariel Expósito Seco, Yamilé Vega Hurtado, Bárbara Estupiñán Días, Isabel Fernández, Laura García Pupo, Marquiza Sablón Carrazana, Chryslaine Rodríguez-Tanty, Roberto Menéndez Soto Del Valle, William Almaguer-Melian
Alzheimer's disease is the most common neurodegenerative disease, and its treatment is lacking. In this work, we tested Amylovis-201, a naphthalene-derived compound, as a possible therapeutic candidate for the treatment of AD. For this purpose, we performed three experiments. In the first and third experiment, animals received a bilateral administration of streptozotocin and, starting 24 h after injection, a daily dose of Amylovis-201 (orally), for 17 days or for the whole time of the experiment respectively (28 days), after which learning and memory, as well as the number of hippocampal dentate gyrus cells, were assessed...
March 1, 2024: Brain Research
https://read.qxmd.com/read/38429404/a-randomised-controlled-trial-investigating-the-causal-role-of-the-medial-prefrontal-cortex-in-mediating-self-agency-during-speech-monitoring-and-reality-monitoring
#22
JOURNAL ARTICLE
Songyuan Tan, Yingxin Jia, Namasvi Jariwala, Zoey Zhang, Kurtis Brent, John Houde, Srikantan Nagarajan, Karuna Subramaniam
Self-agency is the awareness of being the agent of one's own thoughts and actions. Self-agency is essential for interacting with the outside world (reality-monitoring). The medial prefrontal cortex (mPFC) is thought to be one neural correlate of self-agency. We investigated whether mPFC activity can causally modulate self-agency on two different tasks of speech-monitoring and reality-monitoring. The experience of self-agency is thought to result from making reliable predictions about the expected outcomes of one's own actions...
March 1, 2024: Scientific Reports
https://read.qxmd.com/read/38424282/more-than-fear-brain-activation-patterns-of-dental-phobic-patients-before-and-after-an-exposure-based-treatment
#23
JOURNAL ARTICLE
André Wannemueller, Jürgen Margraf, Martin Busch, Hans-Peter Jöhren, Boris Suchan
Hyperactivation of brain networks conferring defensive mobilization is assumed to underlie inappropriate defensive-preparation in patients with Specific Phobia. However, studies targeting Dental Phobia (DP) yielded quite heterogeneous results and research concerning the effects of exposure treatments on phobic brain activation so far is missing. This functional Magnetic Resonance Imaging (fMRI) study aimed to investigate activation patterns in DP patients during exposure to phobia-related stimuli and the effects of an exposure-based fear treatment on phobia-related activation...
March 1, 2024: Journal of Neural Transmission
https://read.qxmd.com/read/38418583/cognitive-reserve-predicts-episodic-memory-enhancement-induced-by-transcranial-direct-current-stimulation-in-healthy-older-adults
#24
JOURNAL ARTICLE
Marco Sandrini, Rosa Manenti, Elena Gobbi, Ilaria Pagnoni, Andrea Geviti, Cristina Alaimo, Elena Campana, Giuliano Binetti, Maria Cotelli
Episodic memory shows the largest degree of age-related decline. Anodal transcranial Direct Current Stimulation (tDCS) can enhance episodic memory in aging but there is also evidence of response variability even when using identical stimulation parameters. To explore which inter-individual factors (i.e. age, education, encoding performance, cognitive reserve, tDCS group and timing of tDCS application) may directly and/or indirectly modulate verbal memory recall, we used data from our previous tDCS studies that showed enhanced episodic memory recall in 80 healthy older adults...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38414872/metacognitive-beliefs-of-efficacy-about-daily-life-situations-and-use-of-cognitive-strategies-in-amnestic-mild-cognitive-impairment-a-cross-sectional-study
#25
JOURNAL ARTICLE
Grigoria Bampa, Despina Moraitou, Panagiota Metallidou, Elvira Masoura, Georgia Papantoniou, Maria Sofologi, Georgios Kougioumtzis, Efthymios Papatzikis, Magdalini Tsolaki
Metacognition, the ability to monitor and regulate cognitive processes, is essential for individuals with Mild Cognitive Impairment (MCI) to accurately identify their deficits and effectively manage them. However, previous studies primarily focused on memory awareness in MCI, neglecting other domains affected in daily life. This study aimed to investigate how individuals with MCI perceive their abilities to handle various cognitively challenging situations representing real-life scenarios and their use of compensatory strategies...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38409930/morin-improves-learning-and-memory-in-healthy-adult-mice
#26
JOURNAL ARTICLE
Hilda Martínez-Coria, Norma Serrano-García, Héctor E López-Valdés, Gabriela Sinaí López-Chávez, José Rivera-Alvarez, Ángeles Romero-Hernández, Francisca Fernández Valverde, Marisol Orozco-Ibarra, Mónica Adriana Torres-Ramos
BACKGROUND: Morin is a flavonoid found in many edible fruits. The hippocampus and entorhinal cortex play crucial roles in memory formation and consolidation. This study aimed to characterize the effect of morin on recognition and space memory in healthy C57BL/6 adult mice and explore the underlying molecular mechanism. METHODS: Morin was administered i.p. at 1, 2.5, and 5 mg/kg/24 h for 10 days. The Morris water maze (MWM), novel object recognition, novel context recognition, and tasks were conducted 1 day after the last administration...
February 2024: Brain and Behavior
https://read.qxmd.com/read/38407638/effects-of-estrogen-on-spatial-navigation-and-memory
#27
JOURNAL ARTICLE
Gina Joue, Tobias Navarro-Schröder, Johannes Achtzehn, Scott Moffat, Nora Hennies, Johannes Fuß, Christian Döller, Thomas Wolbers, Tobias Sommer
RATIONALE: Animal studies suggest that the so-called "female" hormone estrogen enhances spatial navigation and memory. This contradicts the observation that males generally out-perform females in spatial navigation and tasks involving spatial memory. A closer look at the vast number of studies actually reveals that performance differences are not so clear. OBJECTIVES: To help clarify the unclear performance differences between men and women and the role of estrogen, we attempted to isolate organizational from activational effects of estrogen on spatial navigation and memory...
February 26, 2024: Psychopharmacology
https://read.qxmd.com/read/38405165/the-impact-of-long-term-care-insurance-pilot-on-the-mental-health-of-older-adults-quasi-experimental-evidence-from-china
#28
JOURNAL ARTICLE
Lianjie Wang
The Chinese government launched pilot programs for a long-term care insurance system in response to the ongoing increase in the aging population. This study uses the difference-in-differences (DID) model to analyze the impact of long-term care insurance on older adults' mental health based on China Health and Retirement Longitudinal Study (CHARLS) four-period panel data from 2011 to 2018. This study found that long-term care insurance reduced Center for Epidemiological Studies Depression Scale (CES-D) scores among older adults by 1...
March 2024: SSM—Population Health
https://read.qxmd.com/read/38403657/investigating-the-effect-of-hypertension-on-vascular-cognitive-impairment-by-using-the-resting-state-functional-connectome
#29
JOURNAL ARTICLE
Tai-Hsin Hung, Vincent Chin-Hung Chen, Yu-Chen Chuang, Yen-Hsuan Hsu, Wen-Chau Wu, Yuan-Hsiung Tsai, Roger S McIntyre, Jun-Cheng Weng
Hypertension (HTN) affects over 1.2 billion individuals worldwide and is defined as systolic blood pressure (BP) ≥ 140 mmHg and diastolic BP ≥ 90 mmHg. Hypertension is also considered a high risk factor for cerebrovascular diseases, which may lead to vascular cognitive impairment (VCI). VCI is associated with executive dysfunction and is also a transitional stage between hypertension and vascular dementia. Hence, it is essential to establish a reliable approach to diagnosing the severity of VCI...
February 25, 2024: Scientific Reports
https://read.qxmd.com/read/38398813/formulated-palmitoylethanolamide-supplementation-improves-parameters-of-cognitive-function-and-bdnf-levels-in-young-healthy-adults-a-randomised-cross-over-trial
#30
JOURNAL ARTICLE
Nadia Kim, Brenda Parolin, Derek Renshaw, Sanjoy K Deb, Mohammed Gulrez Zariwala
BACKGROUND: Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator which is naturally produced in the body and found in certain foods. The aim of this study was to assess the effect of a bioavailable formulated form of PEA (Levagen+® ) on serum BDNF levels and parameters of cognitive function in healthy adults. METHODS: A randomised double-blinded placebo-controlled cross-over trial was implemented to measure the effects of a 6-week 700 mg/day course of formulated PEA supplementation versus a placebo...
February 8, 2024: Nutrients
https://read.qxmd.com/read/38391674/design-and-control-of-a-soft-knee-exoskeleton-for-pediatric-patients-at-early-stages-of-the-walking-learning-process
#31
JOURNAL ARTICLE
Paloma Mansilla Navarro, Dorin Copaci, Dolores Blanco Rojas
Pediatric patients can suffer from different motor disorders that limit their neurological and motor development and hinder their independence. If treated at the very early stages of development, those limitations can be palliated or even removed. However, manual interventions are not completely effective due to the restrictions in terms of time, force, or tracking experienced by the physiotherapists. The knee flexo-extension is crucial for walking and often affected by disorders such as spasticity or lack of force in the posterior chain...
February 15, 2024: Bioengineering
https://read.qxmd.com/read/38387716/brain-network-analysis-of-working-memory-in-schizophrenia-based-on-multi-graph-attention-network
#32
JOURNAL ARTICLE
Ping Lin, Geng Zhu, Xinyi Xu, Zhen Wang, Xiaoou Li, Bin Li
The cognitive impairment in schizophrenia (SZ) is characterized by significant deficits in working memory task. In order to explore the brain changes of SZ during a working memory task, we performed time-domain and time-frequency analysis of event related potentials (ERP) of SZ during a 0-back task. The P3 wave amplitude was found to be significantly lower in SZ patients than in healthy controls (HC) (p < 0.05). The power in the θ and α bands was significantly enhanced in the SZ group 200 ms after stimulation, while the θ band was significantly enhanced and the β band was weakened in the HC group...
February 20, 2024: Brain Research
https://read.qxmd.com/read/38372217/enhancing-squat-movement-classification-performance-with-a-gated-long-short-term-memory-with-transformer-network-model
#33
JOURNAL ARTICLE
Xinyao Hu, Wenyue Zhang, Haopeng Ou, Shiwei Mo, Fenjie Liang, Junshi Liu, Zhong Zhao, Xingda Qu
Bodyweight squat is one of the basic sports training exercises. Automatic classification of aberrant squat movements can guide safe and effective bodyweight squat exercise in sports training. This study presents a novel gated long-short term memory with transformer network (GLTN) model for the classification of bodyweight squat movements. Twenty-two healthy young male participants were involved in an experimental study, where they were instructed to perform bodyweight squat in nine different movement patterns, including one acceptable movement defined according to the National Strength and Conditioning Association and eight aberrant movements...
February 19, 2024: Sports Biomechanics
https://read.qxmd.com/read/38370801/sars-cov-2-infection-elucidates-unique-features-of-pregnancy-specific-immunity
#34
Dong Sun Oh, Eunha Kim, Guangqing Lu, Rachelly Normand, Lydia L Shook, Amanda Lyall, Olyvia Jasset, Stepan Demidkin, Emily Gilbert, Joon Kim, Babatunde Akinwunmi, Jessica Tantivit, Alice Tirard, Benjamin Y Arnold, Kamil Slowikowski, Marcia B Goldberg, Michael R Filbin, Nir Hacohen, Long H Nguyen, Andrew T Chan, Xu G Yu, Jonathan Z Li, Lael Yonker, Alessio Fasano, Roy H Perlis, Ofer Pasternak, Kathryn J Gray, Gloria B Choi, David A Drew, Pritha Sen, Alexandra-Chloé Villani, Andrea G Edlow, Jun R Huh
Pregnancy is a risk factor for increased severity of SARS-CoV-2 and other respiratory infections. The mechanisms underlying this risk have not been well-established, partly due to a limited understanding of how pregnancy shapes immune responses. To gain insight into the role of pregnancy in modulating immune responses at steady state and upon perturbation, we collected peripheral blood mononuclear cells (PBMC), plasma, and stool from 226 women, including 152 pregnant individuals (n = 96 with SARS-CoV-2 infection and n = 56 healthy controls) and 74 non-pregnant women (n = 55 with SARS-CoV-2 and n = 19 healthy controls)...
February 7, 2024: medRxiv
https://read.qxmd.com/read/38368286/mitochondrial-transportation-transplantation-and-subsequent-immune-response-in-alzheimer-s-disease-an-update
#35
REVIEW
Pegah Javadpour, Fatemeh Abbaszadeh, Abolhassan Ahmadiani, Mohsen Rezaei, Rasoul Ghasemi
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by memory impairment and a progressive decline in cognitive function. Mitochondrial dysfunction has been identified as an important contributor to the development of AD, leading to oxidative stress and energy deficits within the brain. While current treatments for AD aim to alleviate symptoms, there is an urgent need to target the underlying mechanisms. The emerging field of mitotherapy, which involves the transplantation of healthy mitochondria into damaged cells, has gained substantial attention and has shown promising results...
February 17, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38356896/shame-on-me-love-me-tender-inducing-and-reducing-shame-and-fear-in-social-anxiety-in-an-analogous-sample
#36
JOURNAL ARTICLE
Jakob Fink-Lamotte, Jürgen Hoyer, Pauline Platter, Christian Stierle, Cornelia Exner
BACKGROUND: Shame is considered an important factor in the development and maintenance of many psychological disorders, e.g., social anxiety disorder, and an interesting target point for therapeutic intervention. METHOD: In the present experimental study, we used an online-adopted Autobiographical Emotional Memory Task (AEMT) to induce shame and tested different micro-interventions (self-compassion, cognitive reappraisal, and a control intervention) with respect to their potential to reduce shame intensity...
September 2023: Clin Psychol Eur
https://read.qxmd.com/read/38355017/decision-making-ability-limitations-and-brain-neural-activity-changes-in-healthcare-workers-after-mild-covid-19
#37
JOURNAL ARTICLE
Yaotian Gao, Keyi Lin, Bangyue Wang, Wei Ji, Jia Liu, Mengcheng Du, Wei Wang, Yan Li, Xiaowen Du, Yuyang Wang, Tao Jiang
Studies have demonstrated that the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) extensively affects brain function. Although cognitive dysfunction is considered a common manifestation in COVID-19 patients during the recovery period, the potential changes in decision-making ability, are not yet clear. Decision-making functions are essential to the work of healthcare workers. However, there is a lack of a multidimensional assessment of its functioning in COVID-19 cases. Here, we used tests combined with the resting-state functional magnetic resonance imaging (rs-fMRI) stabilization feature amplitude of low-frequency fluctuations (ALFF) to explore decision-making behavior and brain neural activity changes in healthcare workers after mild COVID-19...
February 12, 2024: Neuroscience Research
https://read.qxmd.com/read/38354898/a-brief-real-time-fnirs-informed-neurofeedback-training-of-the-prefrontal-cortex-changes-brain-activity-and-connectivity-during-subsequent-working-memory-challenge
#38
JOURNAL ARTICLE
Xi Yang, Yixu Zeng, Guojuan Jiao, Xianyang Gan, David Linden, Dennis Hernaus, Chaozhe Zhu, Keshuang Li, Dezhong Yao, Shuxia Yao, Yihan Jiang, Benjamin Becker
Working memory (WM) represents a building-block of higher cognitive functions and a wide range of mental disorders are associated with WM impairments. Initial studies have shown that several sessions of functional near-infrared spectroscopy (fNIRS) informed real-time neurofeedback (NF) allow healthy individuals to volitionally increase activity in the dorsolateral prefrontal cortex (DLPFC), a region critically involved in WM. For the translation to therapeutic or neuroenhancement applications, however, it is critical to assess whether fNIRS-NF success transfers into neural and behavioral WM enhancement in the absence of feedback...
February 12, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38354730/-the-immune-system-of-the-critically-ill-patient
#39
JOURNAL ARTICLE
Marie Vogeler, Judith Schenz, Eckhard Müller, Markus Weigand, Dania Fischer
Critically ill patients often experience a dysregulated immune response, leading to immune dysfunction. Sepsis, trauma, severe infections, and certain medical conditions can trigger a state of systemic inflammation, known as the cytokine storm. This hyperactive immune response can cause collateral damage to healthy tissues and organs, exacerbating the patient's condition. On the other hand, some critically ill patients may suffer from immune paralysis which can increase the risk of nosocomial infections.Fever is an evolutionary adaptation that evolved as an effective defense mechanism to fight invading pathogens...
February 2024: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://read.qxmd.com/read/38350168/aberrant-b-cell-receptor-signaling-in-circulating-na%C3%A3-ve-and-iga-memory-b-cells-from-newly-diagnosed-autoantibody-positive-rheumatoid-arthritis-patients
#40
JOURNAL ARTICLE
Stefan F H Neys, Judith W Heutz, Jennifer A C van Hulst, Madelief Vink, Ingrid M Bergen, Pascal H P de Jong, Erik Lubberts, Rudi W Hendriks, Odilia B J Corneth
OBJECTIVE: Altered B cell receptor (BCR) signaling has been implicated in the pathogenesis of rheumatoid arthritis (RA). Here we aimed to identify signaling aberrations in autoantibody-positive and autoantibody-negative RA patients by performing a comprehensive analysis of the BCR signaling cascade in different B cell subsets. METHODS: We first optimized phosphoflow cytometry for an in-depth analysis of BCR signaling across immunoglobulin isotypes in healthy donors...
February 12, 2024: Journal of Autoimmunity
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