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https://www.readbyqxmd.com/read/28441584/the-efficacy-and-safety-of-aripiprazole-for-tic-disorders-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#1
Shuai Wang, Yan-Zhao Wei, Jian-Hong Yang, Yu-Ming Zhou, Yu-Hang Cheng, Chao Yang, Yi Zheng
The aims are to evaluate the efficacy and safety of aripiprazole for tic disorders (TDs) in children and adolescents. We searched PubMed, Embase, PsychINFO, Cochrane database as well as Chinese databases of CNKI, VIP, CBM and Wanfang from the database inception to October 2016, and 17 full-text studies (N=1305) were included in our article. The meta-analysis of 10 studies (N=817) showed that there was no significant difference in the reduction of total YGTSS score between aripiprazole and other drugs, and meta-analysis of 7 studies (n=324) which used tic symptom control ≧30% as outcome measure showed that there was no significant difference between aripiprazole and other treatments...
April 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28439753/abating-mercury-exposure-in-young-children-should-include-thimerosal-free-vaccines
#2
REVIEW
José G Dórea
Pediatric immunization is essential to prevent, control and eradicate children`s infectious diseases. Newborns and infants in less developed countries have a concentrated schedule of Thimerosal-containing vaccines (TCVs); pregnant mothers are also immunized with TCVs. Metabolic changes during early development are demonstrably an important risk factor for ethylmercury (EtHg) effects on neurodevelopment, while exposure to Thimerosal sensitizes susceptible individuals to life-long contact dermatitis. Concerns regarding toxicity of Hg have moved rich nations to withdraw it from medicines and, in particular, Thimerosal from pediatric vaccines; it has been more than 20 years since rich countries started using Thimerosal-free vaccines...
April 24, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28433655/targeting-sarcoma-tumor-initiating-cells-through-differentiation-therapy
#3
Dan Han, Veronica Rodriguez-Bravo, Elizabeth Charytonowicz, Elizabeth Demicco, Josep Domingo-Domenech, Robert G Maki, Carlos Cordon-Cardo
Human leukocyte antigen class I (HLA-I) down-regulation has been reported in many human cancers to be associated with poor clinical outcome. However, its connection to tumor-initiating cells (TICs) remains unknown. In this study, we report that HLA-I is down-regulated in a subpopulation of cells that have high tumor initiating capacity in different types of human sarcomas. Detailed characterization revealed their distinct molecular profiles regarding proliferation, apoptosis and stemness programs. Notably, these TICs can be induced to differentiate along distinct mesenchymal lineages, including the osteogenic pathway...
April 13, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28429606/parent-and-patient-perceptions-of-functional-impairment-due-to-tourette-syndrome-development-of-a-shortened-version-of-the-child-tourette-syndrome-impairment-scale
#4
Kara S Francis Barfell, Ryan R Snyder, Kelly M Isaacs-Cloes, Jordan F Garris, Alyssa R Roeckner, Paul S Horn, Michael D Guthrie, Steve W Wu, Donald L Gilbert
The Child Tourette Syndrome Impairment Scale (CTIM) rates 37 problems in school, social, and home domains separately for tics and for comorbid diagnoses. However, a shorter version would be easier to implement in busy clinics. Using published data from 85 children with Tourette syndrome, 92 controls, and parents, factor analysis was used to generate a "mini-CTIM" composed of 12 items applied to tic and comorbid diagnoses. Child- and parent-rated mini-CTIM scores were compared and correlated across raters and accounting for clinician-rated tic severity and presence of attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD)...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28429239/development-and-initial-validation-of-a-short-three-dimensional-inventory-of-character-strengths
#5
Wenjie Duan, He Bu
PURPOSE: Character strength is described as a positive and organized pattern of emotions, thoughts, and behaviors. It serves as a schema that organizes categories of information toward the self, others, and the world, and provides the self-aware knowledge that facilitates the pursuit of goals, values, and ethical principles. Recent research has suggested that three reliable factors emerge from the measures of character strengths: caring, inquisitiveness, and self-control. The goal of this paper is to develop a psychometrically sound short measure of character strength...
April 20, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28428278/oncogenic-role-of-snd1-in-development-and-progression-of-hepatocellular-carcinoma
#6
Nidhi Jariwala, Devaraja Rajasekaran, Rachel G Mendoza, Xue-Ning Shen, Ayesha Siddiq, Maaged Akiel, Chadia L Robertson, Mark A Subler, Jolene Windle, Paul B Fisher, Arun J Sanyal, Devanand Sarkar
SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). In this study, we show that hepatocyte-specific SND1 transgenic mice (Alb/SND1 mice) develop spontaneous HCC with partial penetrance and exhibit more highly aggressive HCC induced by chemical carcinogenesis. Livers from Alb/SND1 mice exhibited a relative increase in inflammatory markers and spheroid-generating tumor initiating cells (TIC). Mechanistic investigations defined roles for Akt and NF-kappaB signaling pathways in promoting TIC formation in Alb/SND1 mice...
April 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28427799/assessing-cumulative-acute-toxicity-of-chemoradiotherapy-in-head-and-neck-cancer-with-or-without-induction-chemotherapy
#7
Bhartesh A Shah, Muhammad M Qureshi, Jennifer M Logue, Timothy P Cooley, Ken S Zaner, Scharukh Jalisi, Minh Tam Truong
BACKGROUND: To compare cumulative acute toxicity in head and neck cancer patients treated with concurrent chemoradiotherapy alone (CCRT) versus induction chemotherapy (IC) followed by CCRT (I/CCRT). METHODS: 77 patients underwent definitive CCRT (30 I/CCRT and 47 CCRT). Toxicity was graded using the Common Terminology Criteria for Adverse Events version 4.0. Using the TAME adverse event reporting system, short-term toxicity (T) scores were generated for IC (TIC), CCRT (TCCRT), total treatment duration (TRx), post-treatment period (TPT) and an overall score (Toverall) from treatment start to post treatment period...
April 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28423056/hair-and-stress-a-pilot-study-of-hair-and-cytokine-balance-alteration-in-healthy-young-women-under-major-exam-stress
#8
Eva M J Peters, Yvonne Müller, Wenke Snaga, Herbert Fliege, Anett Reißhauer, Thomas Schmidt-Rose, Heiner Max, Dorothea Schweiger, Matthias Rose, Johannes Kruse
Mouse models show that experimental stress mimicking prolonged life-stress exposure enhances neurogenic inflammation, induces adaptive immunity cytokine-imbalance characterized by a shift to Type 1 T-helper cell cytokines and increases apoptosis of epithelial cells. This affects hair growth in otherwise healthy animals. In this study, we investigate whether a prolonged naturalistic life-stress exposure affects cytokine balance and hair parameters in healthy humans. 33 (18 exam, 15 comparison) female medical students with comparable sociobiological status were analyzed during a stressful final examination period, at three points in time (T) 12 weeks apart...
2017: PloS One
https://www.readbyqxmd.com/read/28418483/tics-and-tourette-syndrome
#9
Christopher C Muth
No abstract text is available yet for this article.
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28413935/predictive-validity-of-the-k-sads-pl-2009-version-in-school-aged-and-adolescent-outpatients
#10
Håkan Jarbin, Markus Andersson, Maria Råstam, Tord Ivarsson
BACKGROUND: The schedule for affective disorders and schizophrenia for school-age children (K-SADS) is one of the most commonly used standardized diagnostic interviews in child and adolescent psychiatry. Validity studies are scarce, and limited to concurrent validity with other measures and clinical diagnoses. AIMS: To evaluate the K-SADS interview in an outpatient child and adolescent psychiatry (CAP) setting with a Longitudinal Expert All Data (LEAD) procedure...
May 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28400598/molecular-dynamics-study-of-ferroelectric-domain-nucleation-and-domain-switching-dynamics
#11
Vishal Boddu, Florian Endres, Paul Steinmann
Ferroelectric materials contain domains of ordered electric dipoles, separated by domain walls, that can undergo polarisation switching under externally applied electric fields. The domain switching dynamics in ferroelectric materials plays an essential role in their application to electronic and electro-optic de- vices. Previous studies suggest that the switching occurs largely through domain wall motion which is explained from the viewpoint of statistical physics on surface growth as the behaviour of a pinned elas- tic interface...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388026/temperature-dependent-lithium-ion-diffusion-and-activation-energy-of-li1-2co0-13ni0-13mn0-54o2-thin-film-cathode-at-nanoscale-by-using-electrochemical-strain-microscopy
#12
Shan Yang, Binggong Yan, Jiaxiong Wu, Li Lu, Kaiyang Zeng
This paper presents the in situ mapping of temperature-dependent lithium-ion diffusion at the nanometer level in thin film Li1.2Co0.13Ni0.13Mn0.54O2 cathode using electrochemical strain microscopy. The thin-film Li1.2Co0.13Ni0.13Mn0.54O2 cathode exhibits higher lithium-ion diffusivities with increasing temperature, which explains the higher capacity observed in the lithium-ion batteries with a Li-rich cathode at elevated temperature. In addition, the activation energy for lithium-ion diffusion can be extracted in an Arrhenius-type plot at the level of grain structure with the assumption that the ionic movement is diffusion controlled...
April 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28387621/deep-brain-stimulation-for-tourette-syndrome-a-single-center-series
#13
Richard S Dowd, Michael Pourfar, Alon Y Mogilner
OBJECTIVE Tourette syndrome (TS) is a complex neuropsychiatric disorder characterized by multiple motor and phonic tics. While pharmacological and behavioral therapy can be effective in most patients, a subset of patients remains refractory to treatment. Increasing clinical evidence from multiple centers suggests that deep brain stimulation (DBS) of the medial thalamus can be effective in many cases of refractory TS. METHODS The authors retrospectively reviewed outcomes in 13 patients with refractory TS who underwent medial thalamic DBS performed by their team over a 7-year period...
April 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28387387/deutetrabenazine-treatment-of-hyperkinetic-aspects-of-huntington-s-disease-tardive-dyskinesia-and-tourette-syndrome
#14
D M Paton
Deutetrabenazine is a derivative of tetrabenazine in which two trideuteromethoxy groups substitute two methoxy groups. The active metabolites of deutetrabenazine have a longer half-life than those of tetrabenazine, together with a greater overall absorption. However, the peak plasma concentrations are lower. Because of these pharmacokinetic differences, deutetrabenazine can be given twice daily, thus improving compliance. The lower peak concentrations may account for a lower incidence of some unwanted adverse effects...
February 2017: Drugs of Today
https://www.readbyqxmd.com/read/28384832/obsessive-compulsive-disorder-advances-in-diagnosis-and-treatment
#15
Matthew E Hirschtritt, Michael H Bloch, Carol A Mathews
Importance: Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder associated with significant impairment and a lifetime prevalence of 1% to 3%; however, it is often missed in primary care settings and frequently undertreated. Objective: To review the most current data regarding screening, diagnosis, and treatment options for OCD. Evidence Review: We searched PubMed, EMBASE, and PsycINFO to identify randomized controlled trials (RCTs), meta-analyses, and systematic reviews that addressed screening and diagnostic and treatment approaches for OCD among adults (≥18 years), published between January 1, 2011, and September 30, 2016...
April 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28382107/tetrabenazine-in-treatment-of-hyperkinetic-movement-disorders-an-observational-study
#16
Rita Miguel, Marcelo D Mendonça, Raquel Barbosa, Filipa Ladeira, Tânia Lampreia, José Vale, Paulo Bugalho
BACKGROUND: Tetrabenazine (TBZ) is commonly used in hyperkinetic movement disorders. In this retrospective study, we aimed to assess the TBZ effectiveness and adverse events (AEs) in Huntington disease (HD), vascular chorea, tics, dystonia, tardive oromandibular (OM) dyskinesia and other tardive syndromes (TS). METHODS: Qualitative analysis of clinical response was used to estimate TBZ effectiveness. TBZ-associated AE frequency and subsequent discontinuation rate were used to estimate tolerability; the tolerability profile was measured through the TBZ minimal dose and exposure time required to elicit AEs...
February 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28379724/parsing-the-phenotype-of-obsessive-compulsive-tic-disorder-octd-a-multidisciplinary-consensus
#17
Bernardo Dell'Osso, Donatella Marazziti, Umberto Albert, Stefano Pallanti, Orsola Gambini, Antonio Tundo, Carlotta Zanaboni, Domenico Servello, Renata Rizzo, Luciana Scalone, Beatrice Benatti, A Carlo Altamura, Mauro Porta
Obsessive-Compulsive Disorder (OCD) and Tic Disorder (TD) are highly disabling and often comorbid conditions. Of note, the DSM-5 acknowledged a new 'tic-related' specifier for OCD, which might be referred to as Obsessive-Compulsive Tic Disorder (OCTD), raising new interest toward a better clinical characterisation of affected patients. Available literature indicates that early onset, male gender, sensory phenomena and obsessions of symmetry, aggressiveness, hoarding, exactness and sounds as well as comorbidity with Attention Deficit Hyperactivity Disorder (ADHD) may be of more frequent observation in patients with OCTD...
February 24, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28376560/hypoxia-mediated-epigenetic-regulation-of-stemness-in-brain-tumor-cells
#18
Pankaj Prasad, Shivani Arora Mittal, Jonita Chongtham, Sujata Mohanty, Tapasya Srivastava
Activation of pluripotency regulatory circuit is an important event in solid tumor progression and the hypoxic microenvironment is known to enhance the stemness feature of some cells. The distinct population of cancer stem cells (CSCs)/tumor initiating cells exist in a niche and augment invasion, metastasis, and drug resistance. Previously, studies have reported global hypomethylation and site-specific aberrant methylation in gliomas along with other epigenetic modifications as important contributors to genomic instability during glioma progression...
April 4, 2017: Stem Cells
https://www.readbyqxmd.com/read/28372940/clonidine-use-in-the-outpatient-management-of%C3%A2-severe-secondary-dystonia
#19
C Sayer, D E Lumsden, M Kaminska, J-P Lin
OBJECTIVE: To evaluate the safety, efficacy and effective dosage of clonidine in the outpatient (OP) management of secondary dystonia. METHODS: A retrospective analysis of children and young people (CAYP) prescribed clonidine in an OP clinic between January 2011 and November 2013 for dystonia management. Of 224 children receiving clonidine, 149/224 did not have a movement disorder and 12/224 had no data leaving 63 movement disorder cases, 15/63 managed as in-patients, 15/48 suffered from tics leaving 33/63 for OP evaluation...
March 14, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28370063/total-variation-based-dce-mri-decomposition-by-separating-lesion-from-background-for-time-intensity-curve-estimation
#20
Hui Liu, Yuanjie Zheng, Dong Liang, Pinpin Tang, Fuquan Ren, Lina Zhang, Weizuo Zhao
PURPOSE: This study aims to obtain the accurate time intensity curve (TIC) of a dynamic contrast-enhanced magnetic resonance image (DCE-MRI) by eliminating the normal tissue enhancement and obtaining pure lesion information. The TIC of DCE-MRI is sometimes distorted because of the influence of normal tissue. In this paper, a new tracer-kinetic modeling based on total variation (DC-TV) is proposed to address this problem by decomposing the DCE-MRI into the normal tissue image and the lesion image...
March 30, 2017: Medical Physics
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