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https://www.readbyqxmd.com/read/28919236/biomarkers-for-diagnosis-of-pediatric-acute-neuropsychiatric-syndrome-pans-sensitivity-and-specificity-of-the-cunningham-panel
#1
Eva Hesselmark, Susanne Bejerot
OBJECTIVE: Pediatric Acute Neuropsychiatric Syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are conditions marked by sudden onset of obsessive-compulsive disorder (OCD), tics, or avoidant/restrictive food intake in combination with multiple psychiatric symptoms. A diagnosis of PANS or PANDAS may be supported by the Cunningham Panel, a commercially available set of immunologic assays currently in clinical use. However, the relationship between Cunningham Panel results and patient symptoms remains unclear...
September 9, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28915150/tics-and-tourette-a-clinical-pathophysiological-and-etiological-review
#2
Russell C Dale
PURPOSE OF REVIEW: Describe developments in the etiological understanding of Tourette syndrome. RECENT FINDINGS: Tourette syndrome is a complex heterogenous clinical syndrome, which is not a unitary entity. Pathophysiological models describe gamma-aminobutyric acid-ergic-associated disinhibition of cortico-basal ganglia motor, sensory and limbic loops. MRI studies support basal ganglia volume loss, with additional white matter and cerebellar changes. Tourette syndrome cause likely involves multiple vulnerability genes and environmental factors...
September 14, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28903370/human-mesenchymal-stem-cells-preferentially-migrate-toward-highly-oncogenic-human-hepatocellular-carcinoma-cells-with-activated-epcam-signaling
#3
Berwini Endaya, Shou P Guan, Jennifer P Newman, Hung Huynh, Kian C Sia, Siao T Chong, Catherine Y L Kok, Alexander Y F Chung, Bin B Liu, Kam M Hui, Paula Y P Lam
The epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein that is regarded as one of the markers for tumor initiating cells (TIC) in human hepatocellular carcinoma (HCC). Much work has been directed towards targeting these TICs as a mean of placing these master regulators of cell proliferation and drug resistance under control. Human bone marrow-derived mesenchymal stem cells are known to exhibit an innate property of tumor tropism. However, the possible relationship between MSC and TIC is not well understood...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902635/gc-ms-characterization-of-n-hexane-soluble-fraction-from-dandelion-taraxacum-officinale-weber-ex-f-h-wigg-aerial-parts-and-its-antioxidant-and-antimicrobial-properties
#4
Ivan Ivanov, Nadezhda Petkova, Julian Tumbarski, Ivayla Dincheva, Ilian Badjakov, Panteley Denev, Atanas Pavlov
A comparative investigation of n-hexane soluble compounds from aerial parts of dandelion (Taraxacum officinale Weber ex F.H. Wigg.) collected during different vegetative stages was carried out. The GC-MS analysis of the n-hexane (unpolar) fraction showed the presence of 30 biologically active compounds. Phytol [14.7% of total ion current (TIC)], lupeol (14.5% of TIC), taraxasteryl acetate (11.4% of TIC), β-sitosterol (10.3% of TIC), α-amyrin (9.0% of TIC), β-amyrin (8.3% of TIC), and cycloartenol acetate (5...
September 13, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28901488/the-role-of-fructose%C3%A2-1-6%C3%A2-bisphosphatase-1-in-abnormal-development-of-ovarian-follicles-caused-by-high-testosterone-concentration
#5
Tao Liu, Han Zhao, Jianfeng Wang, Xin Shu, Yuan Gao, Xiaoli Mu, Fei Gao, Hongbin Liu
The present study aimed to identify the molecular mechanisms underlying the effects of the fructose‑1,6‑bisphosphatase 1 (FBP1) signaling pathway within normal follicle development and in hyperandrogenism‑induced abnormal follicle growth. To achieve this, murine primary follicles, granulosa cells (GCs) and theca‑interstitial cells (TICs) were isolated, cultured in vitro and treated with a high concentration of androgens. A concentration of 1x10‑5 mol/l testosterone was considerable to induce hyperandrogenism by MTT assay...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28895315/single-atom-catalysts-of-precious-metals-for-electrochemical-reactions
#6
Jiwhan Kim, Hee-Eun Kim, Hyunjoo Lee
Single-atom catalysts (SACs), where the metal atom is dispersed on the support without forming nanoparticles, have been used for various heterogeneous reactions and most recently for electro-chemical reactions. In this mini-review, we introduce recent exam-ples of single-atom electrocatalysts used for the oxygen reduction reaction (ORR), hydrogen oxidation reaction (HOR), hydrogen evo-lution reaction (HER), formic acid oxidation reaction (FAOR), and methanol oxidation reaction (MOR). Many density functional theory (DFT) simulations have predicted that SACs may be effective for CO2 reduction towards methane or methanol production while sup-pressing H2 evolution, and those cases are introduced here as well...
September 11, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28894297/the-pnkd-gene-is-associated-with-tourette-disorder-or-tic-disorder-in-a-multiplex-family
#7
N Sun, C Nasello, L Deng, N Wang, Y Zhang, Z Xu, Z Song, K Kwan, R A King, Z P Pang, J Xing, G A Heiman, J A Tischfield
Tourette Disorder (TD) is a childhood-onset neuropsychiatric and neurodevelopmental disorder characterized by the presence of both motor and vocal tics. The genetic architecture of TD is believed to be complex and heterogeneous. Nevertheless, DNA sequence variants co-segregating with TD phenotypes within multiplex families have been identified. This report examines whole exomes of affected and unaffected individuals in a multiplex TD family to discover genes involved in the TD etiology. We performed whole exome sequencing on six out of nine members in a three-generation TD multiplex family...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28893660/a-new-rf-transmit-coil-for-foot-and-ankle-imaging-at-7t-mri
#8
Tales Santini, Junghwan Kim, Sossena Wood, Narayanan Krishnamurthy, Nadim Farhat, Carlos Maciel, Shailesh Raval, Tiejun Zhao, Tamer Ibrahim
A four-channel Tic-Tac-Toe (TTT) transmit RF coil was designed and constructed for foot and ankle imaging at 7T MRI. Numerical simulations using an in-house developed FDTD package and experimental analyses using a homogenous phantom show an excellent agreement in terms of B1(+) field distribution and s-parameters. Simulations performed on an anatomically detailed human lower leg model demonstrated an B1(+) field distribution with a coefficient of variation (CV) of 23.9%/15.6%/28.8% and average B1(+) of 0.33μT/0...
September 8, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28888928/an-update-on-new-and-unique-uses-of-botulinum-toxin-in-movement-disorders
#9
Joseph Jankovic
The therapeutic applications of botulinum toxin (BoNT) have grown manifold since its initial approval in 1989 by the US Food and Drug Administration (FDA) for the treatment of strabismus, blepharospasm, and other facial spasms. Although it is the most potent biologic toxin known to man, long-term studies have established its safety in the treatment of a variety of neurologic and non-neurologic disorders. This review focuses on some novel and uncommon uses of BoNT in the treatment of movement disorders, such as oromandibular dystonia, including bruxism, anterocollis, camptocormia, tremor, tics, tardive and levodopa-induced dyskinesia, and restless legs syndrome...
September 6, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28885211/postoperative-control-of-functional-muscle-flaps-for-facial-palsy-reconstruction-ultrasound-guided-tissue-monitoring-using-contrast-enhanced-ultrasound-ceus-and-ultrasound-elastography
#10
A Kehrer, V Mandlik, C Taeger, S Geis, L Prantl, E M Jung
BACKGROUND AND OBJECTIVES: Facial paralysis causes excruciating impairments including facial asymmetry, limited eye closure, oral incontinence and social dysfunction. Modern plastic surgical reconstructions render favorable results with well-perfused dynamic muscle flaps. Post-operative tissue monitoring is a critical determinant for success. Contrast-enhanced Ultrasound (CEUS) and elastography have proven superior properties to evaluate tissue perfusion in various organs. We evaluated their role for functional muscle flaps positioned at the sub-skin level in facial palsy patients...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28885204/quantitative-evaluation-of-real-time-maximum-liver-capacity-limax-and-time-intensity-curve-tic-analysis-in-ceus-based-microperfusion
#11
M Haimerl, K Brünn, S Poelsterl, L P Beyer, I Wiesinger, C Stroszczynski, E-M Jung, P Wiggermann
PURPOSE: To compare the diagnostic performance of real-time maximum liver capacity (LiMAx) with dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation. MATERIALS AND METHODS: 23 patients underwent liver function capacity (LiMAx) test and consecutive or previous CEUS examinations. A bolus injection of 1.4 ml sulfur hexafluoride microbubbles was administered for CEUS measurements (1-6 MHz) and quantitative perfusion analysis (TIC) was performed with an integrated perfusion software using stored cine-loops...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28884737/-the-application-of-the-acupuncture-techniques-for-the-combined-treatment-of-neurotic-tics-in-the-children
#12
V V Polunina, B A Polyaev, O A Laisheva, A N Lobov, S V Pavlova
At present, the frequency of neurosis in the children is growing under the influence of the increasingly intensive stressful factors. The neurotic ticks are one of the manifestations of neurosis in the children characterized by involuntary movements; they are often accompanied by hyperactivity, deficit of attention, fatigue, and headaches. AIM: The objective of the present study was to evaluate the effectiveness of acupuncture used for the treatment of neurotic tics in the children. MATERIAL AND METHODS: The study was carried out at the basis of the department of children's rehabilitation of the Moscow city polyclinic #39...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28881512/-multicenter-investigation-of-the-correlation-between-supraventricular-tachycardia-and-tachycardia-induced-cardiomyopathy-in-children
#13
X M Li, H Y Ge, L Shi, X Q Liu, B J Guo, M T Li, H Jiang, Y Zhang, H J Liu, X C Zheng, A J Li, Y Y Zhang
Objective: This study aimed to investigate the correlation between supraventricular tachycardia (SVT) and tachycardia-induced cardiomyopathy(TIC) in children and assess the risk factors for the development of TIC. Method: One hundred and eighty-three patients were recruited in four hospitals of Beijing diagnosed as SVT were divided into two groups depending on whether or not complicated with TIC. The age, gender, tachycardia type, ventricular rate during tachycardia, frequency of tachycardia episodes and duration of tachycardia were compared between the two groups and risk factors associated with TIC were analyzed...
September 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28878322/altered-topology-of-structural-brain-networks-in-patients-with-gilles-de-la-tourette-syndrome
#14
E Schlemm, B Cheng, F Fischer, C Hilgetag, C Gerloff, G Thomalla
Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by tics. Abnormal neuronal circuits in a wide-spread structural and functional network involved in planning, execution and control of motor functions are thought to represent the underlying pathology. We therefore studied changes of structural brain networks in 13 adult GTS patients reconstructed by diffusion tensor imaging and probabilistic tractography. Structural connectivity and network topology were characterized by graph theoretical measures and compared to 13 age-matched controls...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28876982/preoperative-predicting-malignancy-in-breast-mass-like-lesions-value-of-adding-histogram-analysis-of-apparent-diffusion-coefficient-maps-to-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-improving-confidence-level
#15
Hong-Li Liu, Min Zong, Han Wei, Jian-Juan Lou, Si-Qi Wang, Qi-Gui Zou, Hai-Bin Shi, Yan-Ni Jiang
OBJECTIVE: This study aims to find out the benefits of adding histogram analysis of apparent diffusion coefficient (ADC) maps onto dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting breast malignancy. METHODS: This study included 95 patients who were found with breast mass-like lesions from January 2014 to March 2016 (47 benign and 48 malignant). These patients were estimated by both DCE-MRI and diffusion-weighted imaging (DWI) and classified into two groups, namely, the benign and the malignant...
September 6, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28875267/kingdom-chromista-and-its-eight-phyla-a-new-synthesis-emphasising-periplastid-protein-targeting-cytoskeletal-and-periplastid-evolution-and-ancient-divergences
#16
Thomas Cavalier-Smith
In 1981 I established kingdom Chromista, distinguished from Plantae because of its more complex chloroplast-associated membrane topology and rigid tubular multipartite ciliary hairs. Plantae originated by converting a cyanobacterium to chloroplasts with Toc/Tic translocons; most evolved cell walls early, thereby losing phagotrophy. Chromists originated by enslaving a phagocytosed red alga, surrounding plastids by two extra membranes, placing them within the endomembrane system, necessitating novel protein import machineries...
September 5, 2017: Protoplasma
https://www.readbyqxmd.com/read/28871923/predictive-value-of-intraoperative-sentinel-lymph-node-imprint-cytology-analysis-for-metastasis-in-patients-with-melanoma
#17
Nives Jonjić, Koraljka Rajković Molek, Irena Seili-Bekafigo, Svjetlana Grbac Ivanković, Neva Girotto, Davor Jurišić, Gordana Zamolo, Ira Pavlović Ružić, Larisa Prpić Massari
Since there are no standardized protocols regarding the detection of microscopic melanoma deposits in sentinel lymph nodes (SLN), the aim of this study was to present our experience with intraoperative cytological evaluation of SLN in patients with melanoma. The study included 475 SLN biopsies (SLNB) from 201 patients with primary cutaneous melanoma of intermediate thickness. Each lymph node was cut in half; touch imprint cytology (TIC) preparations of all cut surfaces were performed and stained according to a modified May-Grünwald-Giemsa method...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28870689/tics-and-obsessive-compulsive-disorder-in-relation-to-diet-two-case-reports
#18
M Briguglio, B Dell'Osso, R Galentino, C Zanaboni Dina, G Banfi, M Porta
No abstract text is available yet for this article.
September 1, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28870078/in-situ-nanoreactor-for-photosynthesizing-h2-gas-to-mitigate-oxidative-stress-in-tissue-inflammation
#19
Wei-Lin Wan, Yu-Jung Lin, Hsin-Lung Chen, Chieh-Cheng Huang, Po-Chien Shih, Yu-Ru Bow, Wei-Tso Chia, Hsing-Wen Sung
Hydrogen (H2) gas can reduce cytotoxic reactive oxygen spe-cies (ROS) that are produced in inflamed tissues. Inspired by natural photosynthesis, this work proposes a multicomponent nanoreactor (NR) that comprises chlorophyll a, L-ascorbic acid, and gold nanoparticles that are encapsulated in a liposomal (Lip) system that can produce H2 gas in situ upon photon absorption to mitigate inflammatory responses. Unlike a bulk system that contains free reacting molecules, this Lip NR system provides an optimal reaction environment, facilitating rapid activation of the photosynthesis of H2 gas, locally providing a high therapeu-tic concentration thereof...
September 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28861008/case-of-secondary-tics-associated-with-olanzapine-in-an-adult
#20
Eric W Mills, Lindsay S Shaffer, Fernando S Goes, Akira Sawa, Frederick C Nucifora
Atypical antipsychotic medications, such as risperidone, aripiprazole, and olanzapine, have utility in treating motor tics, particularly in Tourette syndrome. In rare cases, atypical antipsychotic medications have been associated with adult-onset motor tics. Such adverse drug reactions have been documented in response to quetiapine, aripiprazole, and amisulpride. Here, we report, to our knowledge, the first case of adult-onset motor tics related to olanzapine administration.
2017: Frontiers in Psychiatry
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