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Attention Deficit Hyperactive Disorder

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https://www.readbyqxmd.com/read/28929496/a-methylome-wide-association-study-of-trajectories-of-oppositional-defiant-behaviors-and-biological-overlap-with-attention-deficit-hyperactivity-disorder
#1
Edward D Barker, Esther Walton, Charlotte A M Cecil, Richard Rowe, Sara R Jaffee, Barbara Maughan, Thomas G O'Connor, Argyris Stringaris, Alan J Meehan, Wendy McArdle, Caroline L Relton, Tom R Gaunt
In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable...
September 20, 2017: Child Development
https://www.readbyqxmd.com/read/28928677/virtual-reality-objectifies-the-diagnosis-of-psychiatric-disorders-a-literature-review
#2
REVIEW
Martine J van Bennekom, Pelle P de Koning, Damiaan Denys
BACKGROUND: To date, a diagnosis in psychiatry is largely based on a clinical interview and questionnaires. The retrospective and subjective nature of these methods leads to recall and interviewer biases. Therefore, there is a clear need for more objective and standardized assessment methods to support the diagnostic process. The introduction of virtual reality (VR) creates the possibility to simultaneously provoke and measure psychiatric symptoms. Therefore, VR could contribute to the objectivity and reliability in the assessment of psychiatric disorders...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28928644/near-infrared-spectroscopy-based-frontal-lobe-neurofeedback-integrated-in-virtual-reality-modulates-brain-and-behavior-in-highly-impulsive-adults
#3
Justin Hudak, Friederike Blume, Thomas Dresler, Florian B Haeussinger, Tobias J Renner, Andreas J Fallgatter, Caterina Gawrilow, Ann-Christine Ehlis
Based on neurofeedback (NF) training as a neurocognitive treatment in attention-deficit/hyperactivity disorder (ADHD), we designed a randomized, controlled functional near-infrared spectroscopy (fNIRS) NF intervention embedded in an immersive virtual reality classroom in which participants learned to control overhead lighting with their dorsolateral prefrontal brain activation. We tested the efficacy of the intervention on healthy adults displaying high impulsivity as a sub-clinical population sharing common features with ADHD...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28928191/economic-volatility-in-childhood-and-subsequent-adolescent-mental-health-problems-a-longitudinal-population-based-study-of-adolescents
#4
Tormod Bøe, Jens Christoffer Skogen, Børge Sivertsen, Mari Hysing, Keith J Petrie, Eric Dearing, Henrik Daae Zachrisson
OBJECTIVE: The aim of the current paper was to investigate the association between the patterns of duration, timing and sequencing of exposure to low family income during childhood, and symptoms of mental health problems in adolescence. SETTING: Survey administered to a large population-based sample of Norwegian adolescents. PARTICIPANTS: Survey data from 9154 participants of 16-19 years age (53% participation rate; 52.7% girls) were linked to registry-based information about childhood family income from tax return data...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28926497/diagnosis-and-treatment-of-attention-deficit-hyperactivity-disorder
#5
Amy E Vierhile, Donna Palumbo, Heidi Belden
Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder characterized by signs and symptoms of inattention, hyperactivity, and impulsivity that typically begin in childhood. ADHD can persist into adulthood, causing impairments in occupational performance and peer and family relationships. This article reviews the epidemiology, diagnosis, and treatment of ADHD.
October 18, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28925800/investigation-of-attention-deficit-hyperactivity-disorder-adhd-sub-types-in-children-via-eeg-frequency-domain-analysis
#6
Ramazan Aldemir, Esra Demirci, Huseyin Per, Mehmet Canpolat, Sevgi Özmen, Mahmut Tokmakçı
This study aims to investigate the frequency domain effects and changes in Electroencephalographic (EEG) signals in children aged 7-12 years old who were diagnosed with Attention Deficit and Hyperactivity Disorder (ADHD) and which labelled subtypes of ADHD.The study's sample consisted of 20 healthy children and 20 ADHD children as control group. Of the 20 participants who were diagnosed with ADHD, 10 were classified as ADHD-I (inattentive subtype ADHD) and the other 10 were classified as ADHD-C (combined subtype ADHD)...
September 19, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28925314/effect-of-methylphenidate-on-visual-responses-in-the-superior-colliculus-in-the-anaesthetised-rat-role-of-cortical-activation
#7
L Hetherington, E J Dommett, A C Turner, T B Riley, J X Haensel, P G Overton
The mechanism of action of psychostimulant drugs in the treatment of Attention Deficit Hyperactivity Disorder is still largely unknown, although recent evidence suggests one possibility is that the drugs affect the superior colliculus (SC). We have previously demonstrated that systemically administered d-amphetamine attenuates/abolishes visual responses to wholefield light flashes in the superficial layers of the SC in anaesthetised rats, and the present study sought to extend this work to methylphenidate (MPH)...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28924187/the-ipsych2012-case-cohort-sample-new-directions-for-unravelling-genetic-and-environmental-architectures-of-severe-mental-disorders
#8
C B Pedersen, J Bybjerg-Grauholm, M G Pedersen, J Grove, E Agerbo, M Bækvad-Hansen, J B Poulsen, C S Hansen, J J McGrath, T D Als, J I Goldstein, B M Neale, M J Daly, D M Hougaard, O Mors, M Nordentoft, A D Børglum, T Werge, P B Mortensen
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28923721/evidence-of-sexual-dimorphism-of-htr1b-gene-on-major-adult-adhd-comorbidities
#9
Diana Müller, Eugenio H Grevet, Alana C Panzenhagen, Renata B Cupertino, Bruna S da Silva, Djenifer B Kappel, Nina R Mota, Paula Blaya-Rocha, Stefania P Teche, Eduardo S Vitola, Luis A Rohde, Verônica Contini, Diego L Rovaris, Jaqueline B Schuch, Claiton H D Bau
Attention-deficit/hyperactivity disorder (ADHD) is a very common psychiatric disorder across the life cycle and frequently presents comorbidities. Since ADHD is highly heritable, several studies have focused in the underlying genetic factors involved in its etiology. One of the major challenges in this search is the phenotypic heterogeneity, which could be partly attributable to the sexual dimorphism frequently seen in psychiatric disorders. Taking into account the well-known sexual dimorphic effect observed in serotonergic system characteristics, we differentially tested the influence of HTR1B SNPs (rs11568817, rs130058, rs6296 and rs13212041) on ADHD susceptibility and on its major comorbidities according to sex...
September 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28922857/what-can-cortical-development-in-attention-deficit-hyperactivity-disorder-teach-us-about-the-early-developmental-mechanisms-involved
#10
Sara Ambrosino, Patrick de Zeeuw, Lara Marise Wierenga, Sarai van Dijk, Sarah Durston
Studies of Attention-Deficit/Hyperactivity Disorder (ADHD) have shown developmental changes in the cortical mantle. Different dimensions of cortical morphology, such as surface area and thickness, relate to different neurodevelopmental mechanisms. As such, studying multiple dimensions may inform us about the developmental origins of ADHD. Furthermore, results from existing longitudinal samples await replication. Therefore, we conducted a longitudinal study of multiple cortical dimensions in a sizable, independent ADHD sample...
September 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922069/glutamatergic-agents-in-the-treatment-of-compulsivity-and-impulsivity-in-child-and-adolescent-psychiatry-a-systematic-review-of-the-literature
#11
Konstantin Mechler, Alexander Häge, Nina Schweinfurth, Jeffrey C Glennon, Rick M Dijkhuizen, Declan Murphy, Sarah Durston, Steven Williams, Jan K Buitelaar, Tobias Banaschewski, Ralf W Dittmann, The Tactics Consortium
OBJECTIVE: Research has implicated glutamatergic projections between the various frontal subregions in the pathogenesis of compulsivity and impulsivity. Reducing striatal glutamate release, or antagonising the action of glutamate at its receptors, may therefore represent viable treatment strategies. Several glutamatergic agents with regulatory approval for other indications are available and may be of potential benefit in the treatment of compulsivity/impulsivity in psychiatric disorders in paediatric patients...
September 18, 2017: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/28922019/sleep-problems-and-daytime-sleepiness-in-children-with-adhd-associations-with-social-emotional-and-behavioural-functioning-at-school-a-cross-sectional-study
#12
Isabelle Lucas, Melissa Mulraney, Emma Sciberras
BACKGROUND: Sleep problems and daytime sleepiness are common in children with attention-deficit/hyperactivity disorder (ADHD) and are associated with poor parent-reported functional outcomes. However, the potential impact of sleep problems and/or daytime sleepiness on the school functioning of children with ADHD remains unknown. We aimed to determine if sleep problems and daytime sleepiness were associated with the social, emotional and behavioural school-based functioning of children with ADHD and comorbid sleep problems...
September 18, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28921840/the-role-of-cadherin-genes-in-five-major-psychiatric-disorders-a-literature-update
#13
REVIEW
Ziarih Hawi, Janette Tong, Callum Dark, Hannah Yates, Beth Johnson, Mark A Bellgrove
Converging evidence from candidate gene, genome-wide linkage, and association studies support a role of cadherins in the pathophysiology of five major psychiatric disorders including attention deficit hyperactivity disorder, autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). These molecules are transmembrane proteins which act as cell adhesives by forming adherens junctions (AJs) to bind cells within tissues. Members of the cadherin superfamily are also involved in biological processes such as signal transduction and plasticity that have been implicated in the etiology of major psychiatric conditions...
September 18, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28921528/practitioner-review-treatment-of-chronic-insomnia-in-children-and-adolescents-with-neurodevelopmental-disabilities
#14
REVIEW
Oliviero Bruni, Marco Angriman, Fabrizio Calisti, Alessandro Comandini, Giovanna Esposito, Samuele Cortese, Raffaele Ferri
BACKGROUND: Sleep disturbances, in particular insomnia, represent a common problem in children with neurodevelopmental disabilities (NDDs). Currently, there are no approved medications for insomnia in children by the US Food and Drug Administration or European Medicines Agency and therefore they are prescribed off-label. We critically reviewed pediatric literature on drugs as well as nonpharmacological (behavioral) interventions used for sleep disturbances in children with NDDs. METHODS: PubMed, Ovid (including PsycINFO, Ovid MEDLINE(®) , and Embase), and Web of Knowledge databases were searched through February 12, 2017, with no language restrictions...
September 18, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28921526/parsing-heterogeneity-in-attention-deficit-hyperactivity-disorder-using-eeg-based-subgroups
#15
Sandra K Loo, James J McGough, James T McCracken, Susan L Smalley
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous condition for which multiple efforts to characterize brain state differences are underway. The objective of this study was to identify distinct subgroups of resting electroencephalography (EEG) profiles among children with and without ADHD and subsequently provide extensive clinical characterization of the subgroups. METHODS: Latent class analysis was used with resting state EEG recorded from a large sample of 781 children with and without ADHD (N = 620 ADHD, N = 161 Control), aged 6-18 years old...
September 18, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28919767/relationship-between-subtypes-and-symptoms-of-adhd-insomnia-and-nightmares-in-connection-with-quality-of-life-in-children
#16
Julia Grünwald, Angelika Anita Schlarb
OBJECTIVES: This study examined the links between sleep disorders and subtypes of attention deficit-hyperactivity disorder (ADHD-inattention, ADHD-combined, ADHD-hyperactive/impulsive) in childhood. We set up a hypothetical model linking different symptoms of both disorders to construct the underlying and shared pathways. By examining a sample of children with ADHD we firstly tested parts of the model. METHODS: A total of 72 children with symptoms of ADHD (aged 6-13 years; 79...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28919571/reasons-why-children-and-adolescents-with-adhd-stop-and-restart-taking-medicine
#17
William B Brinkman, John O Simon, Jeffery N Epstein
OBJECTIVE: To describe the prevalence of reasons why children and adolescents stop and restart attention-deficit/hyperactivity disorder (ADHD) medicine and whether functional impairment is present after stopping medicine. METHODS: We used the prospective longitudinal cohort from the Multimodal Treatment of Study of Children with ADHD. At the 12 year follow-up when participants were a mean of 21.1 years old, 372 participants (76% male, 64% Caucasian) reported ever taking ADHD medicine...
September 12, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28917364/managing-childhood-and-adolescent-attention-deficit-hyperactivity-disorder-adhd-with-exercise-a-systematic-review
#18
REVIEW
Qin Xiang Ng, Collin Yih Xian Ho, Hwei Wuen Chan, Bob Zheng Jie Yong, Wee-Song Yeo
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders affecting some 8-10% of children worldwide. Increasing research has shed light on the life course of the disorder, suggesting that majority of children with ADHD will continue to have persistent symptoms into adulthood. The mainstay of ADHD management has been pharmacologic and behavioural/psychological interventions, with little attention paid to exercise as a potential management strategy...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28915839/risk-of-mortality-among-children-adolescents-and-adults-with-autism-spectrum-disorder-or-attention-deficit-hyperactivity-disorder-and-their-first-degree-relatives-a-protocol-for-a-systematic-review-and-meta-analysis-of-observational-studies
#19
Ferrán Catalá-López, Brian Hutton, Matthew J Page, Manuel Ridao, Jane A Driver, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia, Rafael Tabarés-Seisdedos
BACKGROUND: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may have a significant negative impact on the health and longevity of those with the disorder and their relatives. The aim of this study will be to analyze the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. METHODS/DESIGN: We will conduct a systematic review and meta-analysis of observational studies...
September 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28915090/evaluating-the-consistency-of-scales-used-in-adult-attention-deficit-hyperactivity-disorder-assessment-of-college-aged-adults
#20
Ayman Saleh, Catherine Fuchs, Warren D Taylor, Frances Niarhos
No abstract text is available yet for this article.
September 15, 2017: Journal of American College Health: J of ACH
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