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Attention Deficit Hyperactive Disorder

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https://www.readbyqxmd.com/read/29349890/case-report-cytochrome-p450-implications-for-comorbid-adhd-and-ocd-pharmacotherapy
#1
Michaela K Hogan, Nikhil P Rao
TOPIC: This case report details the treatment of an early adolescent already receiving treatment for attention-deficit hyperactivity disorder who presents with recurrent obsessive-compulsive disorder. Potential atomoxetine (Strattera) and fluoxetine (Prozac) interactions via Cytochrome P450 (CYP450) pathways are examined and alternate therapies are recommended. PURPOSE: Provide a discussion of psychopharmacogenomics, especially in the case of combining medications, CYP450 enzymes, and clinical implications in the context of the burgeoning field of precision medicine...
January 19, 2018: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/29348192/differential-contributions-of-nucleus-accumbens-subregions-to-cue-guided-risk-reward-decision-making-and-implementation-of-conditional-rules
#2
Stan B Floresco, David R Montes, Maric M T Tse, Mieke van Holstein
The nucleus accumbens (NAc) is a key node within cortico-limbic circuitry for guiding action selection and cost/benefit decision making in situations involving reward uncertainty. Preclinical studies have typically assessed risk/reward decision making using assays where decisions are guided by internally-generated representations of choice-outcome contingencies. Yet, real-life decisions are often influenced by external stimuli that inform about likelihoods of obtaining rewards. How different subregions of the NAc mediate decision making in such situations is unclear...
January 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29348190/pronounced-hyperactivity-cognitive-dysfunctions-and-bdnf-dysregulation-in-dopamine-transporter-knockout-rats
#3
Damiana Leo, Ilya Sukhanov, Francesca Zoratto, Placido Illiano, Lucia Caffino, Fabrizio Sanna, Giulia Messa, Marco Emanuele, Alessandro Esposito, Maria Dorofeikova, Evgeny A Budygin, Liudmila Mus, Evgenia E Efimova, Marco Niello, Stefano Espinoza, Tatyana D Sotnikova, Marius C Hoener, Gianni Laviola, Fabio Fumagalli, Walter Adriani, Raul R Gainetdinov
Dopamine (DA) controls many vital physiological functions and is critically involved in several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder (ADHD). The major function of the plasma membrane dopamine transporter (DAT) is the rapid uptake of released DA into presynaptic nerve terminals leading to control of both the extracellular levels of DA and the intracellular stores of DA. Here, we present a newly developed strain of rats (DAT-knockout, DAT-KO rats) in which the gene encoding the DAT has been disrupted by using zinc finger nuclease technology (ZFN)...
January 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29347983/experiences-of-an-internet-based-support-and-coaching-model-for-adolescents-and-young-adults-with-adhd-and-autism-spectrum-disorder-a-qualitative-study
#4
Helena Sehlin, Britt Hedman Ahlström, Gerhard Andersson, Elisabet Wentz
BACKGROUND: There is a great demand for non-medical treatment and support targeting the needs of adolescents and young adults with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). There is also a lack of qualitative studies providing in-depth insight into these individuals' own experiences within this area. The current study aimed to explore how adolescents and young adults with ADHD, ASD or both experienced taking part in an internet-based support and coaching intervention...
January 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29347861/positive-emotional-attention-bias-in-young-children-with-symptoms-of-adhd
#5
Amanda Cremone, Claudia I Lugo-Candelas, Elizabeth A Harvey, Jennifer M McDermott, Rebecca M C Spencer
Children with attention-deficit/hyperactivity disorder (ADHD) often experience emotional dysregulation. Dysregulation can arise from heightened attention to emotional stimuli. Emotional attention biases are associated with a number of adverse socioemotional outcomes including reward sensitivity and externalizing behaviors. As reward sensitivity and externalizing behaviors are common in children with ADHD, the aim of the current study was to determine whether emotional attention biases are evident in young children with clinically significant ADHD symptoms...
January 18, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29346654/evaluation-of-system-mapping-approaches-in-identifying-patient-safety-risks
#6
Mecit Can Emre Simsekler, James R Ward, P John Clarkson
Objective: While many system mapping approaches (SMAs) have been broadly used in safety-critical industries, few have so far been employed in the healthcare field to assist in the identification of patient safety risks. In this study, we evaluated a set of system modelling approaches to assess their potential contribution to the identification of risks affecting patient safety. The aim was to gain a greater understanding of the practical application of system modelling approaches with the help of the risk categorization framework developed in this study...
January 16, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29346342/attention-deficit-hyperactivity-disorder-medication-prescription-claims-among-privately-insured-women-aged-15-44-years-united-states-2003-2015
#7
Kayla N Anderson, Elizabeth C Ailes, Melissa Danielson, Jennifer N Lind, Sherry L Farr, Cheryl S Broussard, Sarah C Tinker
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects individuals across the lifespan. ADHD medication use among pregnant women is increasing (1), but consensus about the safety of ADHD medication use during pregnancy is lacking. Given that nearly half of U.S. pregnancies are unintended (2), and early pregnancy is a critical period for fetal development, examining trends in ADHD medication prescriptions among reproductive-aged women is important to quantify the population at risk for potential exposure...
January 19, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29344341/treatment-of-adult-adhd-a-clinical-perspective
#8
REVIEW
Josh Geffen, Kieran Forster
Adult attention deficit/hyperactivity disorder (ADHD) has moved from the blurred edge of clinical focus to clear recognition as a prevalent and significant disorder in its own right. It is a relatively common comorbidity which if identified and treated may open the door to better outcomes for hard-to-treat patients. Conversely, failure to identify and treat adult ADHD is linked to negative outcomes. The recognition of the importance of adult ADHD in a subset of our patients challenges us to overcome our anxiety about this diagnosis and prevent the societal marginalization of vulnerable patients...
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29343228/problematic-internet-use-and-psychiatric-co-morbidity-in-a-population-of-japanese-adult-psychiatric-patients
#9
Hille T de Vries, Takashi Nakamae, Kenji Fukui, Damiaan Denys, Jin Narumoto
BACKGROUND: Many studies reported the high prevalence of problematic internet use (PIU) among adolescents (13-50%), and PIU was associated with various psychiatric symptoms. In contrast, only a few studies investigated the prevalence among the adult population (6%). This study aimed to investigate the prevalence of PIU and psychiatric co-morbidity among adult psychiatric patients. METHODS: Three hundred thirty-three adult psychiatric patients were recruited over a 3-month period...
January 17, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29341895/prenatal-paracetamol-exposure-and-child-neurodevelopment-a-review
#10
REVIEW
Ann Z Bauer, David Kriebel, Martha R Herbert, Carl-Gustaf Bornehag, Shanna H Swan
BACKGROUND: The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy. However, recent studies suggest a possible association between APAP use in pregnancy and offspring neurodevelopment. OBJECTIVES: To conduct a review of publications reporting associations between prenatal APAP use and offspring neurodevelopmental outcomes. METHODS: Relevant sources were identified through a key word search of multiple databases (Medline, CINAHL, OVID and TOXNET) in September 2016...
January 13, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29341240/a-case-report-and-literature-review-of-autism-and-attention-deficit-hyperactivity-disorder-in-paediatric-chronic-pain
#11
Camilla Wiwe Lipsker, Margareta von Heijne, Sven Bölte, Rikard K Wicksell
Psychiatric disorders are common in paediatric patients with chronic pain, but the overall prevalence of comorbid neurodevelopmental disorders is unclear. We report on a case of severe chronic pain in a child with undiagnosed comorbid autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), where significant improvements in pain and function occurred following methylphenidate medication and parental behavioural training. CONCLUSION: The inclusion of behavioural assessment and screening for neurodevelopmental comorbidity may be essential in addressing complex paediatric chronic pain...
January 17, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29341214/cue-reactivity-habituation-and-eating-in-the-absence-of-hunger-in-children-with-loss-of-control-eating-and-attention-deficit-hyperactivity-disorder
#12
Anja Hilbert, Susanne Kurz, Daniela Dremmel, Susann Weihrauch Blüher, Simone Munsch, Ricarda Schmidt
OBJECTIVE: Childhood loss of control (LOC) eating and attention-deficit/hyperactivity disorder (ADHD) are highly comorbid conditions and present with disordered eating behaviors, such as overeating. This study sought to delineate shared and specific abnormalities in physiological, cognitive-motivational, and behavioral components of food-specific impulsivity in children with LOC eating and ADHD. Specifically, children's reactivity and habituation to food and eating in the absence of hunger were examined...
January 17, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29340801/maternal-depression-trajectories-from-pregnancy-to-3%C3%A2-years-postpartum-are-associated-with-children-s-behavior-and-executive-functions-at-3-and-6%C3%A2-years
#13
Mina Park, Ursula Brain, Ruth E Grunau, Adele Diamond, Tim F Oberlander
The objective of this study was to investigate how patterns of maternal depressive symptoms from mid-pregnancy to 3 years postpartum are associated with children's behavior at age 3 years and executive functions. Maternal depressive symptoms were measured from mid-pregnancy to 3 years postpartum. Growth mixture modeling was used on standardized maternal depression scores (n = 147) to identify trajectories. Children's behavioral problems and mental health symptomatology (internalizing, externalizing, and attention deficit hyperactivity disorder) were obtained at 3 and 6 years...
January 16, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29339723/fasoracetam-in-adolescents-with-adhd-and-glutamatergic-gene-network-variants-disrupting-mglur-neurotransmitter-signaling
#14
Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller, Enda Byrne, Yun R Li, Walter K Kraft, Hakon Hakonarson
The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study reports the safety, pharmacokinetics and responsiveness of the metabotropic glutamate receptor (mGluR) activator fasoracetam (NFC-1), in 30 adolescents, age 12-17 years with ADHD, harboring mutations in mGluR network genes. Mutation status was double-blinded. A single-dose pharmacokinetic profiling from 50-800 mg was followed by a single-blind placebo at week 1 and subsequent symptom-driven dose advancement up to 400 mg BID for 4 weeks...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29337649/neurocognitive-deficits-associated-with-adhd-in-athletes-a-systematic-review
#15
Poyrung Poysophon, Ashwin L Rao
CONTEXT: Attention deficit hyperactivity disorder (ADHD) is a common childhood disorder and is frequently diagnosed in young adults. Emerging studies suggest a relationship between ADHD and concussion. OBJECTIVE: To determine whether athletes with ADHD are at increased risk for neurocognitive deficits related to concussion risk, symptom reporting, and recovery. DATA SOURCES: A comprehensive search of PubMed, CINAHL, PsychInfo, and Cochrane Library databases was performed...
January 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29337279/suprathreshold-fiber-cluster-statistics-leveraging-white-matter-geometry-to-enhance-tractography-statistical-analysis
#16
Fan Zhang, Weining Wu, Lipeng Ning, Gloria McAnulty, Deborah Waber, Borjan Gagoski, Kiera Sarill, Hesham M Hamoda, Yang Song, Weidong Cai, Yogesh Rathi, Lauren J O'Donnell
This work presents a suprathreshold fiber cluster (STFC) method that leverages the whole brain fiber geometry to enhance statistical group difference analyses. The proposed method consists of 1) a well-established study-specific data-driven tractography parcellation to obtain white matter tract parcels and 2) a newly proposed nonparametric, permutation-test-based STFC method to identify significant differences between study populations. The basic idea of our method is that a white matter parcel's neighborhood (nearby parcels with similar white matter anatomy) can support the parcel's statistical significance when correcting for multiple comparisons...
January 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29336733/impaired-visuospatial-short-term-memory-in-children-with-adhd
#17
Tadamasa Narimoto, Naomi Matsuura, Michio Hiratani
Previous studies provide clear evidence that visuospatial memory performance in children with attention-deficit/hyperactivity disorder (ADHD) is significantly lower than in typically developing children. In the present study, we investigated a major cause of their low performance using a spatial span test. Possibly, inattention resulting from lack of motivation or interest causes their low performance so that they do not correctly encode targets to be remembered. On the other hand, a deficit in temporary maintenance per se may cause their low performance; that is, their inefficient use of rehearsal during a retention interval may lead to memory traces' fast decay...
January 16, 2018: Journal of Genetic Psychology
https://www.readbyqxmd.com/read/29336086/learning-to-blast-a-way-into-crime-or-just-good-clean-fun-examining-aggressive-play-with-toy-weapons-and-its-relation-with-crime
#18
Sven Smith, Christopher J Ferguson, Kevin M Beaver
BACKGROUND: Researchers, such as Bandura, have proposed that children's mere exposure to the use of play weapons encourages deviant displays of aggression, but there is very little research to support this hypothesis of 20 years. AIM: To examine the relationship between amount of weapon play and concurrent aggression as well as later violent juvenile crime, while controlling for other variables possibly influencing criminal pathways. METHOD: Using longitudinal survey data collected from mothers and children (n = 2019) from age 5, with follow-up at age 15, correlations between children's play with toy weapons and juvenile criminality were examined...
January 16, 2018: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/29335588/peripheral-iron-levels-in-children-with-attention-deficit-hyperactivity-disorder-a-systematic-review-and-meta-analysis
#19
Ping-Tao Tseng, Yu-Shian Cheng, Cheng-Fang Yen, Yen-Wen Chen, Brendon Stubbs, Paul Whiteley, Andre F Carvalho, Dian-Jeng Li, Tien-Yu Chen, Wei-Cheng Yang, Chia-Hung Tang, Che-Sheng Chu, Wei-Chieh Yang, Hsin-Yi Liang, Ching-Kuan Wu, Pao-Yen Lin
There is growing recognition that the risk of attention-deficit hyperactivity disorder (ADHD) in children may be influenced by micronutrient deficiencies, including iron. We conducted this meta-analysis to examine the association between ADHD and iron levels/iron deficiency (ID). We searched for the databases of the PubMed, ScienceDirect, Cochrane CENTRAL, and ClinicalTrials.gov up to August 9th, 2017. Primary outcomes were differences in peripheral iron levels in children with ADHD versus healthy controls (HCs) and the severity of ADHD symptoms in children with/without ID (Hedges' g) and the pooled adjusted odds ratio (OR) of the association between ADHD and ID...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335030/preschool-psychiatric-disorders-homotypic-and-heterotypic-continuity-through-middle-childhood-and-early-adolescence
#20
Megan C Finsaas, Sara J Bufferd, Lea R Dougherty, Gabrielle A Carlson, Daniel N Klein
BACKGROUND: Many preschool-age children meet criteria for psychiatric disorders, and rates approach those observed in later childhood and adolescence. However, there is a paucity of longitudinal research examining the outcomes of preschool diagnoses. METHODS: Families with a 3-year-old child (N = 559) were recruited from the community. Primary caregivers were interviewed using the Preschool Age Psychiatric Assessment when children were 3 years old (n = 541), and, along with children, using the Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Version when children were 9 and 12 years old...
January 16, 2018: Psychological Medicine
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