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https://www.readbyqxmd.com/read/29475207/the-impact-of-soccer-match-play-on-the-muscle-damage-response-in-youth-female-athletes
#1
Jonathan D Hughes, Katrina Denton, Rhodri S Lloyd, Jon L Oliver, Mark De Ste Croix
Post-match assessment of creatine kinase (CK) activity and delayed-onset muscle soreness (DOMS) are common markers of exercise-induced muscle damage and recovery status in soccer players. These responses have not been examined in youth female players. This study examined the effect of competitive match play on CK activity and DOMS in elite youth players. Thirty-four elite female players, divided into three chronological age groups (U13, n=11; U15, n=10; U17 n=12). Players completed baseline testing for CK and DOMS that was repeated immediately (for DOMS), 80, 128 and 168 h post-competitive match play for CK...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475154/nursing-students-and-preceptors-experience-of-assessment-during-clinical-practice-a-multilevel-repeated-interview-study-of-student-preceptor-dyads
#2
Karen Johanne Ugland Vae, Maria Engström, Gunilla Mårtensson, Anna Löfmark
Nursing students' learning process during clinical practice is dependent on the quality of their assessment, and the feedback that is given, however an issue that is very little examined. The aim of this study was to investigate student-preceptor dyads and their experiences of mid-course discussions and final assessment. Data were collected through repeated semi-structured individual interviews with 13 dyads close in time to the assessment discussions, and were analyzed by searching for similarities and differences in their experiences...
November 29, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29475129/effects-of-short-term-feeding-of-different-sources-of-fatty-acids-in-pre-mating-diets-on-reproductive-performance-and-blood-metabolites-of-fat-tailed-iranian-afshari-ewes
#3
H Mirzaei-Alamouti, Z Mohammadi, M H Shahir, M Vazirigohar, M Mansouryar
The effects of dietary omega-3 and omega-6 fatty acids (FAs) in pre-mating diets on reproductive performances and metabolic status of ewes have not been well investigated. Therefore, this study investigated the effect of supplementing different source of FAs on different aspects of reproductive performance of fat-tailed Iranian Afshari ewes. Thirty-two cycling, multiparous Afshari ewes were divided into four groups and fed one of the isocaloric and isonitrogenous diets supplemented with Sunflower oil (SFO), Fish oil (FO), calcium salt of palm oil (CaPO) and/or an equal mixture of SFO + FO (SFOFO)...
February 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29475125/reactive-oxygen-species-initiate-a-protective-response-in-plant-roots-to-stress-induced-by-environmental-bisphenol-a
#4
Jiazhi Zhang, Lihong Wang, Qing Zhou, Xiaohua Huang
Bisphenol A (BPA), a contaminant of emerging concern, can affect plant growth and development at high concentrations. Reactive oxygen species (ROS) production is a general primary response in plants to stress. Here, the aim is to investigate whether ROS in plants play protective roles for stress induced by BPA exposure at environmental concentrations. In this study, soybean roots (seedling, flowering and podding stages) were exposed to 1.5 and 3.0 mg L-1 BPA, and ROS response was measured. The relationship between ROS levels and residual BPA content in soybean roots was evaluated...
February 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29475118/kockdown-of-oip5-as1-expression-inhibits-proliferation-metastasis-and-emt-progress-in-hepatoblastoma-cells-through-up-regulating-mir-186a-5p-and-down-regulating-zeb1
#5
Ze Zhang, Feng Liu, Fan Yang, Yahui Liu
Long non-coding RNA OIP5-AS1 has been studied in human diseases, including several kinds of cancers. It was not studied or reported in hepatoblastoma, so we chose it to do our research in hepatoblastoma. We thought OIP5-AS1 was oncogenic in hepatoblastoma for the high expression of it in hepatoblastoma tissues and cells. OIP5-AS1 knockdown was carried out in cancer cells. Unsurprisingly, this action was verified to be able to inhibit cell proliferation, metastasis and EMT progress in hepatoblastoma. We then measured the low expression level of miR-186a-5p and the high expression level of ZEB1 in hepatoblastoma tissues and cells...
February 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29475111/pth-1-34-and-growth-hormone-in-prevention-of-disuse-osteopenia-and-sarcopenia-in-rats
#6
Mikkel Bo Brent, Annemarie Brüel, Jesper Skovhus Thomsen
Osteopenia and sarcopenia develops rapidly during disuse. The study investigated whether intermittent parathyroid hormone (1-34) (PTH) and growth hormone (GH) administered alone or in combination could prevent or mitigate disuse osteopenia and sarcopenia in rats. Disuse was achieved by injecting 4 IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats. Seventy-two rats were divided into six groups: 1. Baseline; 2. Ctrl; 3. BTX; 4. BTX + GH; 5. BTX + PTH; 6...
February 20, 2018: Bone
https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#7
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475098/xq-1h-protects-against-ischemic-stroke-by-regulating-microglia-polarization-through-ppar%C3%AE-pathway-in-mice
#8
Rui Liu, Junjian Diao, Shucheng He, Binbin Li, Yuxiang Fei, Yunman Li, Weirong Fang
Cerebral ischemic and reperfusion injury often accompany with inflammation, and lead to severe neuronal damage, which further result in neurological disorders and memory disorders. In this study, we researched XQ-1H, a novel derivative of ginkgolide B, protecting against ischemic stroke in mice through regulation of microglia polarization. Middle cerebral artery occlusion (MCAO)/reperfusion in mice is applied to mimic ischemic stroke in vivo. Immediately after MCAO, mice are intragastric administrated with different dose (31 or 62 mg/kg) of XQ-1H for one or continuative three days...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475095/immunomodulatory-effects-of-thionin-thi2-1-from-arabidopsis-thaliana-on-bovine-mammary-epithelial-cells
#9
Marisol Báez-Magaña, Violeta Díaz-Murillo, Joel E López-Meza, Alejandra Ochoa-Zarzosa
Antimicrobial peptides (AMPs) are key elements of plant defense mechanisms, resembling conserved protection strategies also present in mammals. Among the AMPs, plant thionins are particularly interesting due that display antibacterial and antifungal activities. In Arabidopsis thaliana have been described four thionins: Thi2.1, Thi2.2, Thi2.3 and Thi2.4. Work from our group shows that Thi2.1 expressed by bovine endothelial cells has direct antibacterial activity against Staphylococcus aureus mastitis isolates, bacteria able to persist inside bovine mammary epithelial cells (bMECs)...
February 19, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475088/the-arabidopsis-gork-k-channel-is-phosphorylated-by-calcium-dependent-protein-kinase-21-cpk21-which-in-turn-is-activated-by-14-3-3-proteins
#10
P J M van Kleeff, J Gao, S Mol, N Zwart, H Zhang, K W Li, A H de Boer
Potassium (K+ ) is a vital ion for many processes in the plant and fine-tuned ion channels control the K+ -fluxes across the plasma membrane. GORK is an outward-rectifying K+ -channel with important functions in stomatal closure and in root K+ -homeostasis. In this study, post-translational modification of the Arabidopsis GORK ion channel and its regulation by 14-3-3 proteins was investigated. To investigate the possible interaction between GORK and 14-3-3s an in vivo pull-down from an Arabidopsis protein extract with recombinant GORK C-terminus (GORK-C) indeed identified endogenous 14-3-3s (LAMBDA, CHI, NU) as binding partners in a phosphorylation dependent manner...
February 16, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29475073/development-and-preliminary-validation-of-the-parenting-around-snacking-questionnaire-p-snaq
#11
K K Davison, C E Blake, A Kachurak, J C Lumeng, D L Coffman, A L Miller, S O Hughes, T G Power, A F Vaughn, R E Blaine, N Younginer, J O Fisher
Snacking makes significant contributions to children's dietary intake but is poorly understood from a parenting perspective. This research was designed to develop and evaluate the psychometrics of a theoretically grounded, empirically-informed measure of snack parenting. The Parenting around SNAcking Questionnaire (P-SNAQ) was developed using a conceptual model derived from current theory and mixed-methods research to include 20 hypothesized snack parenting practices along 4 parenting dimensions (autonomy support, structure, coercive control and permissiveness)...
February 20, 2018: Appetite
https://www.readbyqxmd.com/read/29475064/ursodeoxycholyl-lysophosphatidylethanolamide-negatively-regulates-tlr-mediated-lipopolysaccharide-response-in-human-thp-1-derived-macrophages
#12
Alzbeta Horvatova, Tanyarath Utaipan, Ann-Christin Otto, Yuling Zhang, Hongying Gan-Schreier, Petr Pavek, Anita Pathil, Wolfgang Stremmel, Walee Chamulitrat
The bile acid-phospholipid conjugate ursodeoxycholyl oleoyl-lysophophatidylethanolamide (UDCA-18:1LPE) is an anti-inflammatory and anti-fibrotic agent as previously shown in cultured hepatocytes and hepatic stellate cells as well as in in vivo models of liver injury. We hypothesize that UDCA-18:1LPE may directly inhibit the activation of immune cells. We found that UDCA-18:1LPE was capable of inhibiting the migration of phorbol ester-differentiated human THP-1 cells. We examined anti-inflammatory activity of UDCA-18:1LPE during activation of THP1-derived macrophages...
February 20, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29475063/characterization-of-a-novel-selective-factor-xa-inhibitor-djt06001-which-reduces-thrombus-formation-with-low-risk-of-bleeding
#13
Xuefeng Hu, Ying Xiao, Chuan Yu, Yinglin Zuo, Wen Yang, Xinan Wang, Baohua Gu, Jing Li
Factor Xa (FXa) is a serine protease that plays key roles in linking the intrinsic and extrinsic coagulation pathways to the final common pathway. DJT06001 is an oral, highly specific and direct FXa inhibitor for the prevention and treatment of thromboembolic diseases. We characterized the compound in vitro and studied its in vivo activity in rat thrombosis models, as well as bleeding risk and Pharmacokinetics and Pharmacodynamics (PK/PD) relationship. DJT06001 inhibited free FXa with an inhibitory constant (Ki) of 0...
February 20, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29475062/resveratrol-suppresses-doxorubicin-induced-cardiotoxicity-by-disrupting-e2f1-mediated-autophagy-inhibition-and-apoptosis-promotion
#14
Jun Gu, Yu-Qi Fan, Hui-Li Zhang, Jian-An Pan, Jian-Ying Yu, Jun-Feng Zhang, Chang-Qian Wang
The clinical use of doxorubicin (DOX) is limited by cardiotoxicity, involving the dysregulation of autophagy and apoptosis in the myocardium, which were partly reversed by resveratrol (RSV) supplement. However, a definitive mechanisms accounting for DOX's cardiotoxicity and the protective role of RSV remain poorly defined. The aim of the present study was to clarify the specific role of E2F transcription factor 1(E2F1) in regulating autophagy and apoptosis in DOX-induced cardiotoxicity as well as the protective effects of RSV...
February 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29475001/regulation-of-tak1-alternative-splicing-by-splice-switching-oligonucleotides
#15
Donghu Zhou, Qianqian Shao, Xu Fan, Peng Wu, Weiran Lin, Handong Wei, Fuchu He, Ying Jiang
Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit different tissue distributions and functions. Aberrant protein isoforms can lead to abnormalities in protein function and may even result in genetic disorders or cancer. In recent years, splice-switching oligonucleotides (SSOs) have emerged as a promising therapeutic strategy for several neurological diseases, but the efficacy of this strategy in other organs is less reported. In this study, we designed and synthesized SSOs targeting the splicing regulators of exon 12 of the Tak1 gene, inducing variant switching between Tak1-A and Tak1-B...
February 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29474960/anti-tumor-efficacy-of-hyaluronan-based-nanoparticles-for-the-co-delivery-of-drugs-in-lung-cancer
#16
Victor Jeannot, Cony Gauche, Silvia Mazzaferro, Morgane Couvet, Laetitia Vanwonterghem, Maxime Henry, Chloé Didier, Julien Vollaire, Véronique Josserand, Jean-Luc Coll, Christophe Schatz, Sébastien Lecommandoux, Amandine Hurbin
Combinations of therapeutic agents could synergistically enhance the response of lung cancer cells. Co-delivery systems capable of transporting chemotherapeutics with different physicochemical properties and with the simultaneous release of drugs remain elusive. Here, we assess the ability of nanoparticles of 30-nm diameter obtained from the self-assembly of hyaluronan-based copolymer targeting CD44 receptors to encapsulate both gefitinib and vorinostat for effective combinational lung cancer treatment. Drug loading was performed by nanoprecipitation...
February 20, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29474936/adiposity-associated-changes-in-serum-glucose-and-adiponectin-levels-modulate-ovarian-steroidogenesis-during-delayed-embryonic-development-in-the-fruit-bat-cynopterus-sphinx
#17
Anuradha, Amitabh Krishna
The aim of the present study was to evaluate the mechanism by which embryonic development in Cynopterus sphinx is impaired during the period of increased accumulation of white adipose tissue during winter scarcity of food. The change in the mass of white adipose tissue during adipogenesis showed significant positive correlation with the circulating glucose level. But increase in circulating glucose level during the adipogenesis showed negative correlation with circulating progesterone and adiponectin levels...
February 20, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29474935/the-use-of-methacholine-provocation-when-assessing-therapeutic-equivalence-between-two-inhalers-in-asthmatic-patients
#18
Thomas Bengtsson, Jonas Román, Tore Persson
A planned change from Bricanyl® (terbutaline) Turbuhaler® M2 to M3 device required a pharmacodynamic study to evaluate therapeutic equivalence of the two devices. Because of the flat dose-response curve for this type of agent over this dose range when assessing bronchodilation, a bronchoprotection study was considered more feasible. In this double-blind, double-dummy, multicentre, single-dose, two-factor, crossover study, patients with stable mild-to-moderate asthma were randomised to 0.5 or 1.5 mg terbutaline via Turbuhaler® M2 or Turbuhaler® M3 followed by a methacholine challenge test...
February 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29474904/intermediate-filament-protein-expression-pattern-and-inflammatory-response-changes-in-kidneys-of-rats-receiving-doxorubicin-chemotherapy-and-quercetin
#19
Samah R Khalil, Amany Tharwat Mohammed, Amir H Abd-Elfatah, Asmaa W Zaglool
The aim of this study was to explore the potential effects of quercetin (QUR) on doxorubicin (DOX)-induced nephrotoxicity. Fifty male rats were assigned to five groups (10 rats each): a control group, a DOX-treated group (total dose, 15 mg/kg bw, intraperitoneally), a QUR-treated group (50 mg/kg bw/day, orally), a prophylaxis co-treated group, and a therapeutic co-treated group. Biochemical parameters and renal function were measured. Moreover, kidney tissues were homogenized for inflammatory marker evaluation and real-time qPCR analysis to determine the changes in intermediate filament protein mRNA levels (desmin, vimentin, connexin 43 and nestin)...
February 20, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29474893/better-airway-resistance-reduction-profile-in-intubated-copd-patients-by-personalized-bronchodilator-dosing-a-pilot-randomized-control-trial
#20
Shin-Hwar Wu, Lih-Jen Shyu, Chin-Hsing Li, Chao-Hung Yu, Huang-Chi Chen, Chew-Teng Kor, Chu-Hsien Wang, Kai-Huang Lin
INTRODUCTION: The optimal dose of inhaled metered-dose bronchodilators for intubated patients with chronic obstructive pulmonary disease (COPD) is unknown. In this study, we proposed a bronchodilator dosing schedule based on an individual's airway resistance (Raw ) and tested its efficacy in reducing Raw . METHODS: A total of 51 newly admitted patients with invasively ventilated COPD were randomly assigned to receive personalized or fixed bronchodilator dosing. Personal target Raw was defined by measuring each individual's Raw after maximal pharmacologic bronchodilatation...
February 20, 2018: Pulmonary Pharmacology & Therapeutics
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