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https://www.readbyqxmd.com/read/29031196/anti-edematogenic-and-anti-inflammatory-activity-of-the-essential-oil-from-croton-rhamnifolioides-leaves-and-its-major-constituent-1-8-cineole-eucalyptol
#1
Anita Oliveira Brito Pereira Bezerra Martins, Lindaiane Bezerra Rodrigues, Francisco Rafael Alves Santana Cesário, Maria Rayane Correia de Oliveira, Cicera Datiane Morais Tintino, Fyama Ferreira E Castro, Isabel Sousa Alcântara, Maria Neyze Martins Fernandes, Thaís Rodrigues de Albuquerque, Maria Sanadia Alexandre da Silva, Adriano Antunes de Sousa Araújo, Lucindo José Quintans Júniur, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley
The species Croton rhamnifolioides, belonging to the Croton genus, is known in ethnomedicine as "quebra faca" and is used in the treatment of stomach pain, vomiting and fever. This study aims to evaluate the anti-edematogenic and anti-inflammatory effect of Croton rhamnifolioides leaf essential oil (OEFC) and its major constituent: 1,8-cineole (eucalyptol). The essential oil was extracted from fresh leaves through a hydrodistillation system. The chemical analysis was determined by gas chromatography-mass spectrometry (GC-MS)...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031159/development-of-fingermarks-on-latex-gloves-the-solution-to-a-challenging-surface
#2
Tomer Arbeli, Yakir Liptz, Ravell Bengiat, Michal Levin-Elad
Used Latex gloves found at crime scenes can provide strong evidence against a suspect as they almost certainly contain both the fingermarks and DNA of the perpetrator who had worn them. However, over the years, Latex gloves have proved to be a rather difficult substrate for fingermarks development, with most of the standard techniques producing poor results. In this study, the two main protocols for development on either porous or non-porous surfaces: Ninhydrin-HFE and superglue fuming followed by crystal violet (CV) dyeing, respectively, had been examined on 100 disposable Latex gloves from twenty five donors...
September 28, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29031155/the-effect-of-nanoparticle-aggregation-on-surfactant-foam-stability
#3
Zuhair A AlYousef, Mohammed A Almobarky, David S Schechter
The combination of nanoparticles (NPs) and surfactant may offer a novel technique of generating stronger foams for gas mobility control. This study evaluates the potential of silica NPs to enhance the foam stability of three nonionic surfactants. Results showed that the concentration of surfactant and NPs is a crucial parameter for foam stability and that there is certain concentrations for strong foam generation. A balance in concentration between the nonionic surfactants and the NPs can enhance the foam stability as a result of forming flocs in solutions...
September 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29031142/protective-effects-of-schisandrin-b-on-cigarette-smoke-induced-airway-injury-in-mice-through-nrf2-pathway
#4
Ruichun Jia, Haogang Zhang, Zhiping Yang, Hong Zhao, Fei Liu, Hui Wang, Meijuan Miao, Qiushi Wang, Yanhong Liu
Schisandrin B (SchB), a dibenzocyclooctadiene derivative isolated from Schisandra chinensis, has been reported to have anti-inflammatory effects. However, the protective effects of SchB on cigarette smoke (CS)-induced lung inflammation remain unclear. This study was to investigate the effects of SchB on CS-induced lung inflammation in mice. The mice were exposed to CS to develop lung inflammation. SchB was given 1h before CS exposure daily for five consecutive days. The levels of inflammatory mediators TNF-α, IL-1β, and IL-6 in bronchoalveolar lavage fluid (BALF) were measured in this study...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29031131/depression-sleep-problems-and-perceived-stress-among-informal-caregivers-in-58-low-middle-and-high-income-countries-a-cross-sectional-analysis-of-community-based-surveys
#5
Ai Koyanagi, Jordan E DeVylder, Brendon Stubbs, André F Carvalho, Nicola Veronese, Josep M Haro, Ziggi I Santini
Caregiving has been associated with adverse health outcomes. However, there is a paucity of multi-country, population-based studies on mental health outcomes of caregivers especially from low- and middle-income countries (LMICs). Thus, we assessed the association of caregiving with depression, sleep problems, and perceived stress in 10 high-, 27 middle-, and 21 low-income countries. Cross-sectional community-based data of the World Health Survey including 258,793 adults aged ≥18 years were analyzed. Multivariable logistic and linear regression analyses were conducted to explore the association of past 12-month caregiving with past 12-month DSM-IV depression, and past 30-day perceived stress [range 0 (low)-100 (high)] and severe/extreme sleep problems...
October 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29031102/identifying-the-loss-of-functional-independence-of-older-people-residing-in-the-community-validation-of-the-prisma-7-instrument-in-brazil
#6
Ana Luiza Flores Saenger, Célia Pereira Caldas, Michel Raîche, Luciana Branco da Motta
The identification of the older people who are functionally dependant is essential for planning interventions with emphasis on secondary and tertiary prevention. Therefore, a simplified tool, able to identify these individuals for a more comprehensive evaluation, is required. However, the use of a measuring tool in a different socio-cultural context requires prior adaptation. This article aims to verify the psychometric properties of the PRISMA-7 in Brazilian context. This instrument was previously shown as able to identify older persons living in the community who have risk of functional loss in a Canadian study...
October 7, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29031078/structural-design-synthesis-and-pharmacological-evaluation-of-thiazoles-against-trypanosoma-cruzi
#7
Gevanio Bezerra de Oliveira Filho, Marcos Veríssimo de Oliveira Cardoso, José Wanderlan Pontes Espíndola, Dayane Albuquerque Oliveira E Silva, Rafaela Salgado Ferreira, Pollyanne Lacerda Coelho, Pâmela Silva Dos Anjos, Emanuelle de Souza Santos, Cássio Santana Meira, Diogo Rodrigo Magalhaes Moreira, Milena Botelho Pereira Soares, Ana Cristina Lima Leite
Chagas disease is one of the most significant health problems in the American continent. benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and exhibit strong side effects and ineffectiveness in the chronic stage, besides different susceptibility among T. cruzi DTUs (Discrete Typing Units). Therefore, new drugs to treat this disease are necessary. Thiazole compounds have been described as potent trypanocidal agents. Here we report the structural planning, synthesis and anti-T...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031023/whole-body-vibration-combined-with-treadmill-training-improves-walking-performance-in-post-stroke-patients-a-randomized-controlled-trial
#8
Wonjae Choi, Donghun Han, Junesun Kim, Seungwon Lee
BACKGROUND Stroke is characterized by an asymmetrical gait pattern that causes poor stability and reduces overall activity levels. The aim of this study was to investigate the effect of whole-body vibration combined with treadmill training (WBV-TT) on walking performance in patients with chronic stroke. MATERIAL AND METHODS Thirty ambulatory chronic stroke patients were randomly allocated to the WBV-TT group or the treadmill training (TT) group. The participants in the WBV-TT group performed 6 types of exercises on a vibrating platform for 4...
October 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29030082/adx-47273-a-mglu5-receptor-positive-allosteric-modulator-attenuates-deficits-in-cognitive-flexibility-induced-by-withdrawal-from-binge-like-ethanol-exposure-in-rats
#9
Marta Marszalek-Grabska, Ewa Gibula-Bruzda, Anna Bodzon-Kulakowska, Piotr Suder, Kinga Gawel, Sylwia Talarek, Joanna Listos, Ewa Kędzierska, Wojciech Danysz, Jolanta H Kotlinska
Repeated exposure to and withdrawal from ethanol induces deficits in spatial reversal learning. Data indicate that metabotropic glutamate 5 (mGlu5) receptors are implicated in synaptic plasticity and learning and memory. These receptors functionally interact with N-methyl-d-aspartate (NMDA) receptors, and activation of one type results in the activation of the other. We examined whether (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-piperidin-1-yl (ADX-47273), a positive allosteric modulator (PAM) of mGlu5 receptor, attenuates deficits in reversal learning induced by withdrawal (11-13days) from 'binge-like' ethanol input (5...
October 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29030070/a-latex-agglutination-assay-to-quantify-the-amount-of-hemagglutinin-protein-in-adjuvanted-low-dose-influenza-monovalent-vaccines
#10
Sophie Buffin, Nabila Ikhelef, Julien Prudent, Joseline Dubayle, Nolwenn Nougarede, Marie-Pierre Varenne, Catherine Moste, Isabelle Legastelois
To formulate inactivated influenza vaccines, the concentration of hemagglutinin (HA) must be accurately determined. The standard test currently used to measure HA in influenza vaccines is the Single Radial Immunodiffusion (SRID) assay. We developed a very rapid, simple and sensitive alternative quantitative HA assay, namely the Latex Agglutination Assay (LAA). The LAA uses the Spherotest(®) technology, which is based on the agglutination of HA-specific immunoglobulin-coated latex beads. The amount of HA in a sample is calculated from the level of bead agglutination by a simple absorbance measurement at 405nm against a standard curve generated using a monovalent vaccine standard...
October 10, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29029365/eighteen-month-lamivudine-prophylaxis-on-preventing-occult-hepatitis-b-virus-hbv-infection-reactivation-in-patients-with-hematologic-malignancies-receiving-immunosuppression-therapy
#11
Aldo Marrone, Nicolina Capoluongo, Chiara D'Amore, Mariantonietta Pisaturo, Mariarosaria Esposito, Salvatore Guastafierro, Isabella Siniscalchi, Margherita Macera, Adriana Boemio, Lorenzo Onorato, Luca Rinaldi, Carmine Minichini, Luigi Elio Adinolfi, Evangelista Sagnelli, Lucia Mastrullo, Nicola Coppola
This study evaluated the long-term efficacy and safety of an 18-month lamivudine prophylaxis in 68 HBsAg-negative/anti-HBc-positive patients with onco-hematological disease. All 68 consecutive HBsAg-negative/anti-HBc-positive patients with an onco-hematological disease and naïve for chemotherapy observed from April 2008 to December 2012 at two Hematology Units in Naples were treated with lamivudine for 18 months after stopping chemotherapy and monitored for HBsAg at months 1 and 3 during chemotherapy and then every three months after its discontinuation...
October 13, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29029355/over-sewing-of-staple-line-in-laparoscopic-sleeve-gastrectomy-initial-experience-of-a-comparative-study
#12
Giorgio Lisi, Roberto Rossini, Irene Gentile, Giacomo Ruffo
INTRODUCTION: The main drawback of laparoscopic sleeve gastrectomy (LSG) is the severity of postoperative complications. Staple line reinforcement (SLR) is strongly advocated. Recently, over-sewing has been proposed as a cost-effective and helpful method for reinforcing the staple line. The purpose of this study was to report our initial experience with LSG comparing over-sewing over the entire staple line with the upper-third staple line. MATERIALS AND METHODS: All obese patients seen at Negrar Sacro Cuore, Don Calabria Hospital were entered into our prospective database and were retrospectively evaluated...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29029336/differential-effects-of-exposure-to-single-versus-a-mixture-of-endocrine-disrupting-chemicals-on-steroidogenesis-pathway-in-mouse-testes
#13
Julio Buñay, Eduardo Larriba, Daniel Patiño-Garcia, Leonor Cruz-Fernandes, Sergio Castañeda-Zegarra, María Rodriguez-Fernandez, Jesús Del Mazo, Ricardo D Moreno
Endocrine-disrupting chemicals (EDCs) generate reproductive dysfunctions affecting the biosynthesis of steroid hormones and genes of the steroidogenic pathway. EDCs effects are mainly reported as a result of exposure to single compounds. However, humans are environmentally exposed to a mixture of EDCs. Herein, we assess chronic exposure to single alkylphenols and phthalates versus a mixture in mouse testes histology and steroidogenesis. Pregnant mice were exposed through drinking water to: 0.3 mg/Kg-body weight (BW)/day of each phthalate (DEHP, DBP, BBP), 0...
September 22, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029198/different-genomic-changes-underlie-adaptive-evolution-in-populations-of-contrasting-history
#14
S G Seabra, I Fragata, M A Antunes, G S Faria, M A Santos, V C Sousa, P Simões, M Matos
Experimental evolution is a powerful tool to understand the adaptive potential of populations under environmental change. Here, we study the importance of the historical genetic background in the outcome of evolution at the genome-wide level. Using the natural clinal variation of Drosophila subobscura, we sampled populations from two contrasting latitudes (Adraga, Portugal and Groningen, Netherlands) and introduced them in a new common environment in the laboratory. We characterized the genome-wide temporal changes underlying the evolutionary dynamics of these populations, which had previously shown fast convergence at the phenotypic level, but not at chromosomal inversion frequencies...
September 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29029163/toxicity-and-sublethal-effects-of-cantharidin-on-musca-domestica-diptera-muscidae
#15
Hassan Yasoob, Hafiz Azhar Ali Khan, Yalin Zhang
The house fly, Musca domestica L. (Diptera: Muscidae), is a major pest of medical and veterinary importance all over the world. Management efforts for house flies are usually compromised owing to their resistance to many groups of conventional insecticides. Cantharidin, a natural toxin produced by meloid beetles, is a biopesticide with a reported toxicity to some insect pests including house flies. However, the effects of cantharidin on biological and fitness parameters of house flies have not yet been investigated...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29029154/interrogating-resilience-in-health-systems-development
#16
Remco van de Pas, Majdi Ashour, Anuj Kapilashrami, Suzanne Fustukian
The Fourth Global Symposium on Health Systems Research was themed around 'Resilient and responsive health systems for a changing world.' This commentary is the outcome of a panel discussion at the symposium in which the resilience discourse and its use in health systems development was critically interrogated. The 2014-15 Ebola outbreak in West-Africa added momentum for the wider adoption of resilient health systems as a crucial element to prepare for and effectively respond to crisis. The growing salience of resilience in development and health systems debates can be attributed in part to development actors and philanthropies such as the Rockefeller Foundation...
September 23, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29029051/multi-locus-sequence-typing-and-virulence-genotyping-of-streptococcus-suis-serotype-9-isolates-revealed-high-genetic-and-virulence-diversity
#17
Wenyang Dong, Yinchu Zhu, Ye Ma, Jiale Ma, Yue Zhang, Lvfeng Yuan, Zihao Pan, Zongfu Wu, Huochun Yao
Streptococcus suis (S. suis) is an important swine pathogen that can cause a variety of diseases. S. suis serotype 9 (SS9) is a prevalent serotype, but limited information is available. Here, we studied and compared 30 SS9 isolates, including 24 isolates from China between year 2004 and 2013, 5 isolates from Vietnam and a serotype reference isolate from Denmark. A MLST analysis was performed to exploit the genetic relationships between those isolates. The phylogenetic tree based on the MLST data divides those isolates into two clades (I and II), revealing different evolutionary paths of collected strains...
September 22, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29029017/region-specific-suppression-of-hypothalamic-responses-to-insulin-to-adapt-to-elevated-maternal-insulin-secretion-during-pregnancy
#18
S R Ladyman, D R Grattan
As part of the adaptation of maternal glucose regulation during pregnancy to ensure glucose provision to the fetus, maternal insulin concentrations become elevated. However, increased central actions of insulin, such as suppression of appetite, would be maladaptive during pregnancy. We hypothesized that central nervous system targets of insulin become less responsive during pregnancy to prevent overstimulation by the increased circulating insulin concentrations. To test this hypothesis, we have measured insulin-induced phosphorylation of Akt (pAkt) in specific hypothalamic nuclei as an index of hypothalamic insulin responsiveness...
September 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028944/identification-and-replication-of-the-interplay-of-four-genetic-high-risk-variants-for-urinary-bladder-cancer
#19
Silvia Selinski, Meinolf Blaszkewicz, Katja Ickstadt, Holger Gerullis, Thomas Otto, Emanuel Roth, Frank Volkert, Daniel Ovsiannikov, Oliver Moormann, Gergely Banfi, Peter Nyirady, Sita H Vermeulen, Montserrat Garcia-Closas, Jonine D Figueroa, Alison Johnson, Margaret R Karagas, Manolis Kogevinas, Nuria Malats, Molly Schwenn, Debra T Silverman, Stella Koutros, Nathaniel Rothman, Lambertus A Kiemeney, Jan G Hengstler, Klaus Golka
Little is known whether genetic variants identified in genome-wide association studies interact to increase bladder cancer risk. Recently, we identified two- and three-variant combinations associated with a particular increase of bladder cancer risk in a urinary bladder cancer case-control series (IfADo, 1501 cases, 1565 controls). In an independent case-control series (Nijmegen Bladder Cancer Study, NBCS, 1468 cases, 1720 controls) we confirmed these two- and three-variant combinations. Pooled analysis of the two studies as discovery group (IfADo-NBCS) resulted in sufficient statistical power to test up to four-variant combinations by a logistic regression approach...
September 27, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028862/alternatives-to-standard-injectables-and-devices-for-rejuvenation
#20
Sabine Zenker
<p>INTRODUCTION: Looking at alternatives to standard injectables and devices for rejuvenation, typical indications for facial rejuvenation are poor skin quality, pigmentary changes, and the loss of shape. Looking for effective treatments for those indications in the aesthetic field, one can notice a kind of "retro"-trend: easy-to-perform, non- or minimally-invasive, low-investment-requiring procedures are regaining a lot of popularity. And, over time, those treatments are becoming well defined and far more specific...
June 1, 2017: Journal of Drugs in Dermatology: JDD
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