Wen-Feng Cai, Lin Jiang, Jialiang Liang, Suchandrima Dutta, Wei Huang, Xingyu He, Zhichao Wu, Christian Paul, Xiang Gao, Meifeng Xu, Onur Kanisicak, Junmeng Zheng, Yigang Wang
Although stem/progenitor cell therapy shows potential for myocardial infarction repair, enhancing the therapeutic efficacy could be achieved through additional genetic modifications. HCLS1-associated protein X-1 (HAX1) has been identified as a versatile modulator responsible for cardio-protective signaling, while its role in regulating stem cell survival and functionality remains unknown. In this study, we investigated whether HAX1 can augment the protective potential of Sca1+ cardiac stromal cells (CSCs) for myocardial injury...
May 7, 2024: Stem cell reviews and reports