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confocal endomicroscopy

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https://www.readbyqxmd.com/read/28078907/the-diagnostic-value-of-confocal-laser-endomicroscopy-for-gastric-cancer-and-precancerous-lesions-among-asian-population-a-system-review-and-meta-analysis
#1
Hai-Ping Zhang, Sheng Yang, Wen-Hua Chen, Teng-Teng Hu, Jun Lin
OBJECTIVE: The objective of this study is to evaluate the diagnostic value of confocal laser endomicroscopy (CLE) in detection of gastric cancer (GC), gastric intraepithelial metaplasia (GIM), and gastric intraepithelial neoplasia (GIN) lesions. METHOD: PubMed, the Cochrane Library, and Wangfang databases were searched to include eligible articles about CLE in detection of gastric lesions. After study selection, quality assessment and data extraction conducted by two reviewers independently, meta-analysis was performed by Meta-Disc 1...
January 12, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28069420/the-authors-herby-confirm-that-this-manuscript-has-neither-been-published-nor-submitted-to-any-other-journal-confocal-laser-endomicroscopy-in-neurosurgery-an-alternative-to-instantaneous-sections
#2
David Breuskin, Jacek Szczygielski, Steffi Urbschat, Yoo-Jin Kim, Joachim Oertel
INTRODUCTION: Intraoperative distinction of brain tumor from the surround brain is one of the crucial challenges in neurooncological surgery. In this study, confocal laser endomicroscope (CLE) findings were directly compared with intraoperative instantaneous sections by the neuropathologist in a blinded fashion. MATERIAL AND METHODS: The imaging device comprises of a rigid endoscope with Hopkins-Rod lenses and a red wave length laser with a scanning depth of 80 μm...
January 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28066614/the-role-of-bronchoscopy-in-the-diagnosis-of-early-lung-cancer-a-review
#3
REVIEW
Marco Andolfi, Rossella Potenza, Rosanna Capozzi, Valeria Liparulo, Francesco Puma, Kazuhiro Yasufuku
Lung cancer is the leading cause of cancer-related deaths worldwide with an overall 5-year survival rate of 17% after diagnoses. Indeed many patients tend to have a very poor prognosis, due to being diagnosed at an advanced stage. Conversely patients who are diagnosed at an early stage have a 5-year survival >70%, indicating that early detection of lung cancer is crucial to improve survival. Although flexible bronchoscopy is a relatively non-invasive procedure for patients suspected of having lung cancer, only 29% of carcinoma in situ (CIS) and 69% of microinvasive tumors were detectable using white light bronchoscopy (WLB) alone...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28045777/capillary-flow-rates-in-the-duodenum-of-pediatric-ulcerative-colitis-patients-are-increased-and-unrelated-to-inflammation
#4
Deenaz Zaidi, Lucas Churchill, Hien Q Huynh, Matthew W Carroll, Rabin Persad, Eytan Wine
BACKGROUND: Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are chronic pediatric disorders. Changes in vasculature are described in IBD but these could be secondary to inflammation and the role in pathogenesis is poorly understood. Assessing circulatory changes in typically unaffected sites in IBD (e.g., duodenum), when inflammation is absent, can identify vascular changes associated with pathogenesis. AIM: To measure capillary flow rates in duodenal mucosa using probe-based confocal laser endomicroscopy (pCLE) during endoscopy in children with IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27999860/fluorescence-confocal-endomicroscopy-of-the-cervix-pilot-study-on-the-potential-and-limitations-for-clinical-implementation
#5
Colin Schlosser, Nico Bodenschatz, Sylvia Lam, Marette Lee, Jessica N McAlpine, Dianne M Miller, Dirk J T Van Niekerk, Michele Follen, Martial Guillaud, Calum E MacAulay, Pierre M Lane
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27990658/identification-of-liver-metastases-with-probe-based-confocal-laser-endomicroscopy-at-two-excitation-wavelengths
#6
Crispin Schneider, Sean P Johnson, Kurinchi Gurusamy, Richard J Cook, Adrien E Desjardins, David J Hawkes, Brian R Davidson, Simon Walker-Samuel
BACKGROUND: Metastasis of colorectal cancer to the liver is the most common indication for hepatic resection in a western population. Incomplete excision of malignancy due to residual microscopic disease normally results in worse patient outcome. Therefore, a method aiding in the real time discrimination of normal and malignant tissue on a microscopic level would be of benefit. MATERIAL AND METHODS: The ability of fluorescent probe-based confocal laser endomicroscopy (pCLE) to identify normal and malignant liver tissue was evaluated in an orthotopic murine model of colorectal cancer liver metastasis (CRLM)...
December 19, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27955751/eus-for-pancreatic-cystic-neoplasms-the-roadmap-to-the-future-is-much-more-than-just-a-few-shades-of-gray
#7
REVIEW
Tejas Kirtane, Manoop S Bhutani
Pancreatic cystic and neoplasms are being diagnosed with increasing frequency. Accurate diagnosis and determination of benign versus malignant lesions is crucial for determining need for surveillance versus surgery or endoscopic therapy as well as avoiding unnecessary surgery in cysts with no malignant potential. Tumor markers such as KRAS and GNAS hold promise, but which molecular marker or a combination of markers is most useful and cost effective remains to be seen. Advanced imaging with confocal laser endomicroscopy can serve as an optical biopsy and play a part in the diagnostic algorithm...
December 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27941379/can-we-improve-transurethral-resection-of-the-bladder-tumour-for-nonmuscle-invasive-bladder-cancer
#8
Esmee Iml Liem, Theo M de Reijke
PURPOSE OF REVIEW: The recurrence rate in patients with nonmuscle invasive bladder cancer is high, and the quality of transurethral resection of the bladder (TURB) tumour influences recurrence risk. We review new methods that aim to improve the effectiveness of TURB, and highlight studies of the past year. RECENT FINDINGS: Several approaches have been explored: bipolar resection is well tolerated and efficient; however, surgical outcomes are not clearly superior to monopolar resection; en-bloc resection seems feasible and well tolerated, and has the potential to improve the quality of tissue for histopathology; enhancement techniques such as photodynamic diagnosis, narrow band imaging, and Image1 S improve tumour detection, whereas photodynamic diagnosis reduces recurrence rates; high-resolution imaging modality such as confocal laser endomicroscopy may provide histopathologic information...
December 9, 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27938785/review-surveillance-of-patients-with-barrett-oesophagus
#9
REVIEW
Sielte Maes, Prateek Sharma, Raf Bisschops
There has been a rapid increase in the incidence of oesophageal adenocarcinoma in most Western countries over the past thirty years. Barrett's oesophagus (BE) is a common premalignant lesion of oesophageal adenocarcinoma, although the risk of developing cancer in BE remains low. Therefore, screening is not recommended in the general population. Surveillance of BE is recommended to detect high grade dysplasia or carcinoma in an early stage, although there is no clear evidence that surveillance leads to a reduced mortality...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27904863/recent-updates-in-the-endoscopic-diagnosis-of-barrett-s-oesophagus
#10
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Despite the low risk of progression per annum, OAC is associated with significant morbidity and mortality, with an estimated 5-year survival of 10%. Furthermore, the incidence of OAC continues to rise globally. Therefore, it is imperative to detect the premalignant phase of BO and follow up such patients accordingly. SUMMARY: The mainstay diagnosis of BO is endoscopy and biopsy sampling...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27888870/latest-advances-in-pancreatic-tumours
#11
José Lariño Noia
Pancreatic cancer continues to have a bleak prognosis. Hardly any therapeutic advances have been made in the last few years and consequently most efforts have focused on preventing its development and on diagnosing precursor lesions. In this regard, the use of statins as a preventive factor and the implementation of screening programmes in high-risk patients are gaining ground. In the field of treatment, there is greater focus on the role of neoadjuvant therapy in pancreatic cancer and on a multimodal approach to the disease, with few advances in effective novel therapies...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27874037/visualizing-epithelial-expression-of-egfr-in-vivo-with-distal-scanning-side-viewing-confocal-endomicroscope
#12
Xiyu Duan, Haijun Li, Juan Zhou, Quan Zhou, Kenn R Oldham, Thomas D Wang
Confocal endomicroscopy is an emerging imaging technology that has recently been introduced into the clinic to instantaneously collect "optical biopsies" in vivo with histology-like quality. Here, we demonstrate a fast scanner located in the distal end of a side-viewing instrument using a compact lens assembly with numerical aperture of 0.5 to achieve a working distance of 100 μm and field-of-view of 300 × 400 μm(2). The microelectromechanical systems (MEMS) mirror was designed based on the principle of parametric resonance and images at 5 frames per second...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866871/endoscopic-ultrasound-of-pancreatic-tumors
#13
M Wangermez
Computed tomography (CT) and endoscopic ultrasound (EUS) are the two most effective techniques for the assessment of pancreatic cancers. CT has revolutionized the field of tumor imaging in pancreatic cancer and is now a well-established imaging technique for diagnosis and staging. However, EUS still plays an important role in several situations, especially when the diagnosis is uncertain or when histopathological confirmation of the lesion is needed. Similarly, regarding cystic lesions, magnetic resonance imaging and CT have very good performances but are often inadequate because the diagnosis can be difficult to establish, while the consequences for the patient are major...
December 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27862291/probe-based-confocal-laser-endomicroscopy-in-the-margin-delineation-of-early-gastric-cancer-for-endoscopic-submucosal-dissection
#14
Jun Chul Park, Yehyun Park, Hyun Ki Kim, Jeong-Hyeon Jo, Chan Hyuk Park, Eun Hye Kim, Da Hyun Jung, Hyunsoo Chung, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
BACKGROUND AND AIM: We evaluated pCLE in the margin delineation of early gastric cancer (EGC) for endoscopic submucosal dissection (ESD) in comparison with white-light imaging with chromoendoscopy (CE). METHODS: We conducted a prospective, randomized controlled study from November 2013 to October 2014 in a tertiary referral hospital. A total of 101 patients scheduled for ESD due to differentiated EGC were randomized into pCLE and CE groups (pCLE 51, CE 50). Markings were made by electrocautery at the proximal and distal tumor margins, as determined by either pCLE or CE...
November 9, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27855380/clinical-correlation-between-real-time-endocytoscopy-confocal-endomicroscopy-and-histopathology-in-the-central-airways
#15
Pallav L Shah, Samuel V Kemp, Richard C Newton, Daniel S Elson, Andrew G Nicholson, Guang-Zhong Yang
BACKGROUND: Lung cancer is one of the commonest malignancies with a worldwide incidence of 1.6 million cases each year. Although the main aetiological factor has been identified (cigarette smoking), the progression of lung cancer from early changes such as dysplasia through to cancer is still not fully understood. Furthermore, current research techniques are reliant on obtaining tissue biopsies, a process that alters the natural history of the very process under investigation. Hence, there is a need for developing optical biopsy techniques...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27853737/validation-of-diagnostic-characteristics-of-needle-based-confocal-laser-endomicroscopy-in-differentiation-of-pancreatic-cystic-lesions
#16
Somashekar G Krishna, Benjamin Swanson, Phil A Hart, Samer El-Dika, Jon P Walker, Sean T McCarthy, Ahmad Malli, Zarine K Shah, Darwin L Conwell
: Background and aims: Endoscopic ultrasound (EUS)-guided needle-based Confocal Laser Endomicroscopy (nCLE) characteristics of pancreatic cystic lesions (PCLs) have been identified in studies where the gold standard surgical histopathology was available in a minority of patients. There are diverging reports of interobserver agreement (IOA) and paucity of intraobserver reliability (IOR). Thus, we sought to validate current EUS-nCLE criteria of PCLs in a larger consecutive series of surgical patients...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27852093/poorly-differentiated-pancreatic-carcinoma-with-sarcomatoid-differentiation-confocal-endomicroscopy-of-an-uncommon-pancreatic-cystic-lesion
#17
Feng Li, Samer El-Dika, Rohan M Modi, Wei Chen, Somashekar G Krishna
No abstract text is available yet for this article.
January 2016: Endoscopy
https://www.readbyqxmd.com/read/27813096/real-time-confocal-laser-endomicroscopic-evaluation-of-primary-liver-cancer-based-on-human-liver-autofluorescence
#18
Harufumi Maki, Yoshikuni Kawaguchi, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasushi Harihara, Norihiro Kokudo
BACKGROUND: Confocal laser endomicroscopy (CLE) is available for real-time microscopic examination. This study aims to evaluate the usefulness of intraoperative CLE examination as a modality to evaluate surgical margins in surgery for primary liver cancer. METHODS: A probe-based CLE system (Cellvizio 100, Mauna Kea Technologies, Paris, France) was used. The subjects comprised seven specimens obtained from six patients with primary liver cancer in November 2015. The probe was manually attached to the surfaces of specimens, and images were collected without external fluorophores...
November 4, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27808042/evaluation-of-confocal-laser-endomicroscopy-for-assessment-and-monitoring-of-therapeutic-response-in-patients-with-inflammatory-bowel-disease
#19
John Gásdal Karstensen
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) have been associated with altered intestinal barrier function. Moreover, it has been proposed that a defective barrier function is related to risk of relapse in patients with quiescent CD. Fluorescein-aided confocal laser endomicroscopy (CLE) is a novel endoscopic method, which enables real-time in vivo microscopy. Hence, the intestinal barrier function can be assessed as part of endoscopic evaluation of patients with inflammatory bowel disease (IBD) by measuring microerosions and fluorescein leakage into the intestinal lumen...
November 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27807370/role-of-endoscopy-in-early-oesophageal-cancer
#20
REVIEW
Jayan Mannath, Krish Ragunath
Incidence of oesophageal adenocarcinoma has increased exponentially in the West over the past few decades. Following detection of advanced cancers, 5-year survival rates remain bleak, making identification of early neoplasia, which has a better outcome, important. Detection of subtle oesophageal lesions during endoscopy can be challenging, and advanced imaging techniques might improve their detection. High-definition endoscopy has become a standard in most endoscopy centres, and this technology probably provides better delineation of mucosal features than standard-definition endoscopy...
November 3, 2016: Nature Reviews. Gastroenterology & Hepatology
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