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confocal endomicroscopy

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https://www.readbyqxmd.com/read/29129041/line-scanning-confocal-microendoscope-for-nuclear-morphometry-imaging
#1
Yubo Tang, Jennifer Carns, Rebecca R Richards-Kortum
Fiber-optic endomicroscopy is a minimally invasive method to image cellular morphology in vivo. Using a coherent fiber bundle as an image relay, it allows additional imaging optics to be placed at the distal end of the fiber outside the body. In this research, we use this approach to demonstrate a compact, low-cost line-scanning confocal fluorescence microendoscope that can be constructed for <$5000. Confocal imaging is enabled without the need for mechanical scanning by synchronizing a digital light projector with the rolling shutter of a CMOS camera...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29110046/-supplementary-optical-techniques-for-the-detection-of-nonmuscle-invasive-bladder-cancer
#2
REVIEW
S Aeishen, Y Dawood, S Papadoukakis, M Horstmann
White light cystoscopy (WL) is the gold standard for the detection of bladder cancer. It can be performed using a rigid or flexible urethrocystoscope. With the more recent introduction of high definition (HD) techniques, WL cystoscopy has been decisively improved. Supplementary optical techniques are also used to improve the detection of bladder cancer. Among these are photodynamic diagnosis (PDD), narrow-band imaging (NBI), S‑technologies of IMAGE1 S, optical coherence tomography (OCT), confocal laser endomicroscopy (CLE), and Raman spectroscopy...
November 6, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29108979/prediction-of-clinical-outcomes-in-crohn-s-disease-by-using-confocal-laser-endomicroscopy-results-from-a-prospective-multicenter-study
#3
Gian Eugenio Tontini, Jonas Mudter, Michael Vieth, Claudia Günther, Valentina Milani, Raja Atreya, Timo Rath, Andreas Nägel, Giorgia Hatem, Giacomo Carlo Sturniolo, Maurizio Vecchi, Markus F Neurath, Peter R Galle, Andrea Buda, Helmut Neumann
BACKGROUND & AIMS: Assessment of prognostic factors in Crohn's disease (CD) patients is of pivotal importance for early intervention and "treat-to-target" strategies. Confocal Laser Endomicroscopy (CLE) enables on demand in vivo characterization of mucosal inflammatory and architectural changes during endoscopy. We prospectively assessed the value of CLE for prediction of clinical outcome parameters in CD. METHODS: Consecutive patients with CD undergoing colonoscopy were included in a multicentre study...
November 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29104910/implementation-of-real-time-probe-based-confocal-laser-endomicroscopy-pcle-for-differentiation-of-colorectal-polyps-during-routine-colonoscopy
#4
Tim D G Belderbos, Martijn G H van Oijen, Leon M G Moons, Peter D Siersema
Background and aims:  Probe-based confocal laser endomicroscopy (pCLE) is used to differentiate between neoplastic and non-neoplastic colorectal polyps during colonoscopy. We aimed to assess the accuracy of two endoscopists starting to use real-time pCLE for differentiation of colorectal polyps and to determine the negative predictive value (NPV) for neoplasia in polyps ≤ 5 mm. Methods:  Patients undergoing colonoscopy in a tertiary hospital were included in this prospective trial...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29089571/in-vivo-near-infrared-imaging-of-erbb2-expressing-breast-tumors-with-dual-axes-confocal-endomicroscopy-using-a-targeted-peptide
#5
Zhenghong Gao, Gaoming Li, Xue Li, Juan Zhou, Xiyu Duan, Jing Chen, Bishnu P Joshi, Rork Kuick, Basma Khoury, Dafydd G Thomas, Tina Fields, Michael S Sabel, Henry D Appelman, Quan Zhou, Haijun Li, Ken Kozloff, Thomas D Wang
ErbB2 expression in early breast cancer can predict tumor aggressiveness and clinical outcomes in large patient populations. Accurate assessment with physical biopsy and conventional pathology can be limited by tumor heterogeneity. We aim to demonstrate real-time optical sectioning using a near-infrared labeled ErbB2 peptide that generates tumor-specific contrast in human xenograft breast tumors in vivo. We used IRDye800CW as the fluorophore, validated performance characteristics for specific peptide binding to cells in vitro, and investigated peak peptide uptake in tumors using photoacoustic tomography...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29067583/feasibility-of-real-time-intestinal-bloodstream-evaluation-using-probe-based-confocal-laser-endomicroscopy-in-a-porcine-intestinal-ischemia-model
#6
Tsuyoshi Takahashi, Rie Nakatsuka, Hisashi Hara, Shigeyoshi Higashi, Kouji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Kiyokazu Nakajima
BACKGROUND: Intestinal ischemia can lead to fatal complications if left unrecognized during surgery. The current techniques of intraoperative microvascular assessment remain subjective. Probe-based confocal laser endomicroscopy (pCLE) has the potential to objectively evaluate microvascular blood flow in real-time setting. The present study evaluated the technical feasibility of real-time intestinal bloodstream evaluation using pCLE in a porcine intestinal ischemia model. METHODS: Seven pigs were used...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29054075/evaluation-of-immunological-markers-of-ovine-vaginal-irritation-implications-for-preclinical-assessment-of-non-vaccine-hiv-preventive-agents
#7
Gregg N Milligan, Gracie Vargas, Kathleen L Vincent, Yong Zhu, Nigel Bourne, Massoud Motamedi
The presence of genital inflammatory responses and a compromised vaginal epithelial barrier have been linked to an increased risk of HIV acquisition. It is important to assure that application of candidate microbicides designed to limit HIV transmission will not cause these adverse events. We previously developed high resolution in vivo imaging methodologies in sheep to assess epithelial integrity following vaginal application of a model microbicide, however characterization of genital inflammation in sheep has not been previously possible...
October 13, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29034764/indeterminate-biliary-strictures-a-simplified-approach
#8
Chencheng Xie, Khalil Aloreidi, Bhavesh Patel, Timothy Ridgway, Thavam Thambi-Pillai, Gary Timmerman, Adeel Khan, Muslim Atiq
Pre-operative evaluation of biliary strictures remains challenging. The dilemma that exists is how to balance the risk of failing to detect malignancy and the potential morbidity caused by unnecessary surgery in patients with benign etiologies. With emerging novel diagnostic modalities, this study aims to assess the efficacy of diagnostic techniques and facilitate a clinical approach to indeterminate biliary strictures. Areas covered: Conventional imaging modalities are crucial in identifying the location of a stricture and are helpful for choosing further diagnostic modalities...
October 23, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29028105/value-of-confocal-laser-endomicroscopy-in-the-diagnosis-of-vocal-cord-lesions
#9
M Goncalves, H Iro, A Dittberner, A Agaimy, C Bohr
OBJECTIVE: The aim of this study was to assess the reliability and limitations of confocal laser endomicroscopy (CLE) for diagnosing lesions of the vocal cords and differentiating malignant from non-malignant lesions. PATIENTS AND METHODS: During microlaryngoscopy, the vocal cords were scanned by probe-based CLE (pCLE: a GastroFlex probe with the Cellvizio® laser system, Mauna Technologies, Paris, France). The video recordings were analyzed and compared with the histological results...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29017290/role-of-advanced-endoscopic-imaging-techniques-in-the-management-of-inflammatory-bowel-disease
#10
REVIEW
Eun Soo Kim
Endoscopy plays a crucial role in the management of inflammatory bowel disease (IBD) in terms of diagnosis, monitoring of mucosal status, and surveillance of colitis-associated neoplasia. Mucosal healing evaluated by endoscopy has been recognized as the target of treatment in the era of powerful biologics therapy. The optimal modality for identifying dysplasia in IBD has yet to be well defined. Increasing progress has recently been made in endoscopic technologies to more accurately assess mucosal inflammation and more effectively detect dysplasia...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28944047/novel-biomarkers-and-endoscopic-techniques-for-diagnosing-pancreaticobiliary-malignancy
#11
REVIEW
Margaret G Keane, Amar Shah, Stephen P Pereira, Deepak Joshi
The UK incidence of pancreatic ductal adenocarcinoma is 9 per 100,000 population, and biliary tract cancer occurs at a rate of 1-2 per 100,000. The incidence of both cancers is increasing annually and these tumours continue to be diagnosed late and at an advanced stage, limiting options for curative treatment. Population-based screening programmes do not exist for these cancers, and diagnosis currently is dependent on symptom recognition, but often symptoms are not present until the disease is advanced. Recently, a number of promising blood and urine biomarkers have been described for pancreaticobiliary malignancy and are summarised in this review...
2017: F1000Research
https://www.readbyqxmd.com/read/28938608/use-of-confocal-laser-endomicroscopy-with-a-fluorescently-labeled-fatty-acid-to-diagnose-colorectal-neoplasms
#12
Feihong Deng, Yuan Fang, Zhiyong Shen, Wei Gong, Tao Liu, Jing Wen, Wanling Zhang, Xianjun Zhu, Hui Zhong, Tong Wang, Fachao Zhi, Biao Nie
Endoscopic treatment for early colorectal cancer closely correlates with patient prognosis. However, endoscopic differentiation between carcinomas and non-neoplastic lesions remains difficult. Here, we topically stained colorectal neoplasms with a fatty acid analogue (BODIPY-FA) and quantified the fluorescent signals using confocal laser endomicroscopy (CLE) and fluorescence microscopy. We also analyzed protein expression in colorectal cancer tissues. We found that expression of fatty acid synthase was elevated, while the expression of fatty acid transporters was reduced in colorectal cancer...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28932568/needle-based-confocal-laser-endomicroscopy-in-the-diagnosis-of-peripheral-pulmonary-nodule-a-preliminary-report
#13
Zhuquan Su, Changhao Zhong, Shiyue Li, Xiaobo Chen, Yu Chen, Chunli Tang
Lung cancer is one of the most fatal cancers in the world. To early distinguish benign and malignant pulmonary nodule is critical for disease prognosis. Confocal laser endomicroscopy (CLE) can be used to explore bronchus mucous membrane, alveolar elastic fiber structures and microvessels, and could be helpful for the diagnostic imaging and for the localization guidance. In this report, we presented two cases of peripheral pulmonary nodule. Under the guidance of X-ray and endobronchial ultrasound, needle-based confocal laser endomicroscopy (nCLE) could directly approach the peripheral pulmonary nodule via an exploratory puncture needle...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931888/automatic-classification-of-cancerous-tissue-in-laserendomicroscopy-images-of-the-oral-cavity-using-deep-learning
#14
Marc Aubreville, Christian Knipfer, Nicolai Oetter, Christian Jaremenko, Erik Rodner, Joachim Denzler, Christopher Bohr, Helmut Neumann, Florian Stelzle, Andreas Maier
Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer of the oral epithelium. Despite their high impact on mortality, sufficient screening methods for early diagnosis of OSCC often lack accuracy and thus OSCCs are mostly diagnosed at a late stage. Early detection and accurate outline estimation of OSCCs would lead to a better curative outcome and a reduction in recurrence rates after surgical treatment. Confocal Laser Endomicroscopy (CLE) records sub-surface micro-anatomical images for in vivo cell structure analysis...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929643/demons-registration-for-in-vivo-and-deformable-laser-scanning-confocal-endomicroscopy
#15
Wei-Ming Chiew, Feng Lin, Hock Soon Seah
A critical effect found in noninvasive in vivo endomicroscopic imaging modalities is image distortions due to sporadic movement exhibited by living organisms. In three-dimensional confocal imaging, this effect results in a dataset that is tilted across deeper slices. Apart from that, the sequential flow of the imaging-processing pipeline restricts real-time adjustments due to the unavailability of information obtainable only from subsequent stages. To solve these problems, we propose an approach to render Demons-registered datasets as they are being captured, focusing on the coupling between registration and visualization...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28922432/identifying-a-mucinous-neoplasm-utilizing-confocal-laser-endomicroscopy-branch-duct-gastric-type-intraductal-papillary-mucinous-neoplasm
#16
Amrit K Kamboj, Rohan M Modi, Darwin L Conwell, Somashekar G Krishna
No abstract text is available yet for this article.
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28915142/probe-based-confocal-laser-endomicroscopy-in-metastatic-pulmonary-calcification
#17
Igor Vasilev, Igor Mamenko, Irina Tabanakova, Irina Vikulova, Vera Shevel, Alexey Ushkov, Tatiana Novickaya, Ludmila Archakova, Eugene Sokolovich, Piotr Yablonskii
We report a case of metastatic pulmonary calcification in a patient with chronic renal failure on hemodialysis and secondary hyperparathyroidism. The diagnosis was made by using a probe-based confocal endomicroscopy which showed specific structures in the lung tissue and was proven by a transbronchial lung biopsy. To the best of our knowledge, this is the first reported case of the confocal endomicroscopy findings in a patient with metastatic pulmonary calcification.
September 14, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28886101/high-prevalence-of-gastric-intestinal-metaplasia-detected-by-confocal-laser-endomicroscopy-in-zambian-adults
#18
Violet Kayamba, Aaron Shibemba, Kanekwa Zyambo, Douglas C Heimburger, Douglas R Morgan, Paul Kelly
BACKGROUND: Confocal laser endomicroscopy (CLE) may increase the detection of gastric premalignant lesions, and facilitate targeted biopsies for histology. The study aim was to analyse premalignant lesions in Zambian adults using CLE. METHODS: Using CLE and histology we analysed the antral mucosa for gastric premalignant lesions in asymptomatic adults living with HIV and in HIV seronegative adults. Fasting gastric pH and the presence of Helicobacter pylori (H. pylori) were also evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28885303/validation-of-probe-based-confocal-laser-endomicroscopy-pcle-criteria-for-diagnosing-colon-polyp-histology
#19
Sreekar Vennelaganti, Prashanth Vennalaganti, Sharad Mathur, Satish Singh, Mazen Jamal, Vijay Kanakadandi, Tarun Rai, Matthew Hall, Neil Gupta, Venkat Nutalapati, Benjamin Alsop, Benjamin Hornung, Prateek Sharma
BACKGROUND: Validated probe-based confocal endomicroscopy (pCLE) criteria for distinguishing hyperplastic polyps (HPs) and tubular adenomas (TA) have not yet been developed. AIM: To develop pCLE criteria for distinguishing HP from TA and evaluate its performance characteristics among experts. METHODS: pCLE criteria for colon polyp histology were developed and tested in 2 phases prospectively. Phase I: 8 preliminary criteria were developed and tested internally...
September 6, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28874959/clinical-impact-of-confocal-laser-endomicroscopy-in-the-management-of-gastrointestinal-lesions-with-an-uncertain-diagnosis
#20
Carlos Robles-Medranda, Maria Vargas, Jesenia Ospina, Miguel Puga-Tejada, Manuel Valero, Miguel Soria, Gladys Bravo, Carlos Robles-Jara, Hannah Pitanga Lukashok
AIM: To evaluate the clinical impact of confocal laser endomicroscopy (CLE) in the diagnosis and management of patients with an uncertain diagnosis. METHODS: A retrospective chart review was performed. Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included. Baseline characteristics, indications, previous diagnostic studies, findings at the time of CLE, clinical management and histological results were analyzed...
August 16, 2017: World Journal of Gastrointestinal Endoscopy
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