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confocal endomicroscopy

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https://www.readbyqxmd.com/read/27904863/recent-updates-in-the-endoscopic-diagnosis-of-barrett-s-oesophagus
#1
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Despite the low risk of progression per annum, OAC is associated with significant morbidity and mortality, with an estimated 5-year survival of 10%. Furthermore, the incidence of OAC continues to rise globally. Therefore, it is imperative to detect the premalignant phase of BO and follow up such patients accordingly. SUMMARY: The mainstay diagnosis of BO is endoscopy and biopsy sampling...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27888870/latest-advances-in-pancreatic-tumours
#2
José Lariño Noia
Pancreatic cancer continues to have a bleak prognosis. Hardly any therapeutic advances have been made in the last few years and consequently most efforts have focused on preventing its development and on diagnosing precursor lesions. In this regard, the use of statins as a preventive factor and the implementation of screening programmes in high-risk patients are gaining ground. In the field of treatment, there is greater focus on the role of neoadjuvant therapy in pancreatic cancer and on a multimodal approach to the disease, with few advances in effective novel therapies...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27874037/visualizing-epithelial-expression-of-egfr-in-vivo-with-distal-scanning-side-viewing-confocal-endomicroscope
#3
Xiyu Duan, Haijun Li, Juan Zhou, Quan Zhou, Kenn R Oldham, Thomas D Wang
Confocal endomicroscopy is an emerging imaging technology that has recently been introduced into the clinic to instantaneously collect "optical biopsies" in vivo with histology-like quality. Here, we demonstrate a fast scanner located in the distal end of a side-viewing instrument using a compact lens assembly with numerical aperture of 0.5 to achieve a working distance of 100 μm and field-of-view of 300 × 400 μm(2). The microelectromechanical systems (MEMS) mirror was designed based on the principle of parametric resonance and images at 5 frames per second...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866871/endoscopic-ultrasound-of-pancreatic-tumors
#4
M Wangermez
Computed tomography (CT) and endoscopic ultrasound (EUS) are the two most effective techniques for the assessment of pancreatic cancers. CT has revolutionized the field of tumor imaging in pancreatic cancer and is now a well-established imaging technique for diagnosis and staging. However, EUS still plays an important role in several situations, especially when the diagnosis is uncertain or when histopathological confirmation of the lesion is needed. Similarly, regarding cystic lesions, magnetic resonance imaging and CT have very good performances but are often inadequate because the diagnosis can be difficult to establish, while the consequences for the patient are major...
November 17, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27862291/probe-based-confocal-laser-endomicroscopy-in-the-margin-delineation-of-early-gastric-cancer-for-endoscopic-submucosal-dissection
#5
Jun Chul Park, Yehyun Park, Hyun Ki Kim, Jeong-Hyeon Jo, Chan Hyuk Park, Eun Hye Kim, Da Hyun Jung, Hyunsoo Chung, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
BACKGROUND AND AIM: We evaluated pCLE in the margin delineation of early gastric cancer (EGC) for endoscopic submucosal dissection (ESD) in comparison with white-light imaging with chromoendoscopy (CE). METHODS: We conducted a prospective, randomized controlled study from November 2013 to October 2014 in a tertiary referral hospital. A total of 101 patients scheduled for ESD due to differentiated EGC were randomized into pCLE and CE groups (pCLE 51, CE 50). Markings were made by electrocautery at the proximal and distal tumor margins, as determined by either pCLE or CE...
November 9, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27855380/clinical-correlation-between-real-time-endocytoscopy-confocal-endomicroscopy-and-histopathology-in-the-central-airways
#6
Pallav L Shah, Samuel V Kemp, Richard C Newton, Daniel S Elson, Andrew G Nicholson, Guang-Zhong Yang
BACKGROUND: Lung cancer is one of the commonest malignancies with a worldwide incidence of 1.6 million cases each year. Although the main aetiological factor has been identified (cigarette smoking), the progression of lung cancer from early changes such as dysplasia through to cancer is still not fully understood. Furthermore, current research techniques are reliant on obtaining tissue biopsies, a process that alters the natural history of the very process under investigation. Hence, there is a need for developing optical biopsy techniques...
November 18, 2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27853737/validation-of-diagnostic-characteristics-of-needle-based-confocal-laser-endomicroscopy-in-differentiation-of-pancreatic-cystic-lesions
#7
Somashekar G Krishna, Benjamin Swanson, Phil A Hart, Samer El-Dika, Jon P Walker, Sean T McCarthy, Ahmad Malli, Zarine K Shah, Darwin L Conwell
: Background and aims: Endoscopic ultrasound (EUS)-guided needle-based Confocal Laser Endomicroscopy (nCLE) characteristics of pancreatic cystic lesions (PCLs) have been identified in studies where the gold standard surgical histopathology was available in a minority of patients. There are diverging reports of interobserver agreement (IOA) and paucity of intraobserver reliability (IOR). Thus, we sought to validate current EUS-nCLE criteria of PCLs in a larger consecutive series of surgical patients...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27852093/poorly-differentiated-pancreatic-carcinoma-with-sarcomatoid-differentiation-confocal-endomicroscopy-of-an-uncommon-pancreatic-cystic-lesion
#8
Feng Li, Samer El-Dika, Rohan M Modi, Wei Chen, Somashekar G Krishna
No abstract text is available yet for this article.
January 2016: Endoscopy
https://www.readbyqxmd.com/read/27813096/real-time-confocal-laser-endomicroscopic-evaluation-of-primary-liver-cancer-based-on-human-liver-autofluorescence
#9
Harufumi Maki, Yoshikuni Kawaguchi, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasushi Harihara, Norihiro Kokudo
BACKGROUND: Confocal laser endomicroscopy (CLE) is available for real-time microscopic examination. This study aims to evaluate the usefulness of intraoperative CLE examination as a modality to evaluate surgical margins in surgery for primary liver cancer. METHODS: A probe-based CLE system (Cellvizio 100, Mauna Kea Technologies, Paris, France) was used. The subjects comprised seven specimens obtained from six patients with primary liver cancer in November 2015. The probe was manually attached to the surfaces of specimens, and images were collected without external fluorophores...
November 4, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27808042/evaluation-of-confocal-laser-endomicroscopy-for-assessment-and-monitoring-of-therapeutic-response-in-patients-with-inflammatory-bowel-disease
#10
John Gásdal Karstensen
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) have been associated with altered intestinal barrier function. Moreover, it has been proposed that a defective barrier function is related to risk of relapse in patients with quiescent CD. Fluorescein-aided confocal laser endomicroscopy (CLE) is a novel endoscopic method, which enables real-time in vivo microscopy. Hence, the intestinal barrier function can be assessed as part of endoscopic evaluation of patients with inflammatory bowel disease (IBD) by measuring microerosions and fluorescein leakage into the intestinal lumen...
November 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27807370/role-of-endoscopy-in-early-oesophageal-cancer
#11
REVIEW
Jayan Mannath, Krish Ragunath
Incidence of oesophageal adenocarcinoma has increased exponentially in the West over the past few decades. Following detection of advanced cancers, 5-year survival rates remain bleak, making identification of early neoplasia, which has a better outcome, important. Detection of subtle oesophageal lesions during endoscopy can be challenging, and advanced imaging techniques might improve their detection. High-definition endoscopy has become a standard in most endoscopy centres, and this technology probably provides better delineation of mucosal features than standard-definition endoscopy...
November 3, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27803901/the-role-of-intraductal-ultrasonography-in-pancreatobiliary-diseases
#12
REVIEW
Bo Sun, Bing Hu
Intraductal ultrasonography (IDUS) provides real-time, cross-sectional imaging of pancreatobiliary ducts and surrounding structures during endoscopic retrograde cholangiopancreatography using a high-frequency ultrasound (US) transducer. Hence, IDUS has been considered a sensitive tool in the evaluation of suspicious choledocholithiasis and neoplasms, to help distinguish between benign and malignant bile duct strictures or wall thickness, and to assess tumor extension and invasion depth. With the rapid development and enriched choices of sensitive diagnostic modalities include but are not limited to endoscopic US, peroral cholangioscopy, and confocal laser endomicroscopy, it is needed to systematically assess the role of IDUS in the investigation of pancreatobiliary diseases...
September 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27756612/feasibility-of-per-oral-cholecystoscopy-and-advanced-gallbladder-interventions-after-eus-guided-gallbladder-stenting-with-videos
#13
Shannon Melissa Chan, Anthony Yuen Bun Teoh, Hon Chi Yip, Vivien Wai Yin Wong, Philip Wai Yan Chiu, Enders Kwok Wai Ng
BACKGROUND AND AIMS: The recent development of endosonography (EUS)-guided gallbladder drainage (EGBD) with a lumen-apposing stent has made endoscopic assessment and advanced gallbladder interventions via the stent possible. The aim of this study was to assess the feasibility and safety of per-oral cholecystoscopy and the types of gallbladder interventions that can be performed. METHODS: This was a retrospective review conducted in the Prince of Wales Hospital from June 2012 to March 2016...
October 15, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27748256/presurgical-mapping-of-basal-cell-carcinoma-or-squamous-cell-carcinoma-by-confocal-laser-endomicroscopy-compared-to-traditional-micrographic-surgery-a-single-centre-prospective-feasibility-study
#14
Alexandra Schulz, Samira Daali, Mehreen Javed, Paul Christian Fuchs, Michael Brockmann, Alhadi Igressa, Patra Charalampaki
BACKGROUND: At present, no ideal diagnostic tools exist in the market to excise cancer tissue with the required safety margins and to achieve optimal aesthetic results using tissue-conserving techniques. OBJECTIVES: In this prospective study, confocal laser endomicroscopy (CLE) and the traditional gold standard of magnifying glasses (MG) were compared regarding the boundaries of in vivo basal cell carcinoma and squamous cell carcinoma. MATERIALS & METHODS: Tumour diameters defined by both methods were measured and compared with those determined by histopathological examination...
October 17, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27741530/epidermoid-cyst-within-an-intrapancreatic-accessory-spleen-endosonography-and-confocal-endomicroscopy-of-an-unusual-pancreatic-cystic-lesion
#15
Rohan M Modi, Amrit K Kamboj, Benjamin Swanson, Darwin L Conwell, Somashekar G Krishna
No abstract text is available yet for this article.
January 2016: Endoscopy
https://www.readbyqxmd.com/read/27739457/multimodal-imaging-of-a-humanized-orthotopic-model-of-hepatocellular-carcinoma-in-immunodeficient-mice
#16
Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F Baumert, Michele Diana, Patrick Pessaux, Eric Robinet
The development of multimodal strategies for the treatment of hepatocellular carcinoma requires tractable animal models allowing for advanced in vivo imaging. Here, we characterize an orthotopic hepatocellular carcinoma model based on the injection of luciferase-expressing human hepatoma Huh-7 (Huh-7-Luc) cells in immunodeficient mice. Luciferase allows for an easy repeated monitoring of tumor growth by in vivo bioluminescence. The intrahepatic injection was more efficient than intrasplenic or intraportal injection in terms of survival, rate of orthotopic engraftment, and easiness...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27734273/past-and-current-trends-in-endoscopic-diagnosis-for-early-stage-gastric-cancer-in-japan
#17
Kazuki Sumiyama
Methodology for the diagnosis and staging of early gastric cancer (EGC) has improved in Japan since the development of the gastro-camera and determination of a definition of EGC. Imaging technology has been steadily evolving in the endoscopy field. Improvements in the resolution of standard endoscopy images used in screening and surveillance provide greater opportunities to find gastric cancer earlier. Image enhancement endoscopy (IEE), such as narrow band imaging (NBI), highlights mucosal structures and vascularity...
October 12, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27711949/advanced-endoscopic-imaging-european-society-of-gastrointestinal-endoscopy-esge-technology-review
#18
James E East, Jasper L Vleugels, Philip Roelandt, Pradeep Bhandari, Raf Bisschops, Evelien Dekker, Cesare Hassan, Gareth Horgan, Ralf Kiesslich, Gaius Longcroft-Wheaton, Ana Wilson, Jean-Marc Dumonceau
Background and aim: This technical review is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the utilization of advanced endoscopic imaging in gastrointestinal (GI) endoscopy. Methods: This technical review is based on a systematic literature search to evaluate the evidence supporting the use of advanced endoscopic imaging throughout the GI tract. Technologies considered include narrowed-spectrum endoscopy (narrow band imaging [NBI]; flexible spectral imaging color enhancement [FICE]; i-Scan digital contrast [I-SCAN]), autofluorescence imaging (AFI), and confocal laser endomicroscopy (CLE)...
October 6, 2016: Endoscopy
https://www.readbyqxmd.com/read/27708064/birefringence-microscopy-platform-for-assessing-airway-smooth-muscle-structure-and-function-in-vivo
#19
David C Adams, Lida P Hariri, Alyssa J Miller, Yan Wang, Josalyn L Cho, Martin Villiger, Jasmin A Holz, Margit V Szabari, Daniel L Hamilos, R Scott Harris, Jason W Griffith, Brett E Bouma, Andrew D Luster, Benjamin D Medoff, Melissa J Suter
The inability to visualize airway smooth muscle (ASM) cells in vivo is a major obstacle in understanding their role in normal physiology and diseases. At present, there is no imaging modality available to assess ASM in vivo. Confocal endomicroscopy lacks the penetration depth and field of view, and conventional optical coherence tomography (OCT) does not have sufficient contrast to differentiate ASM from surrounding tissues. We have developed a birefringence microscopy platform that leverages the micro-organization of tissue to add further dimension to traditional OCT...
October 5, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27699107/dual-modality-endomicroscopy-with-co-registered-fluorescence-and-phase-contrast
#20
C Ba, M Palmiere, J Ritt, J Mertz
We describe a dual-modality laser scanning endomicroscope that provides simultaneous fluorescence contrast based on confocal laser endomicroscopy (CLE) and phase-gradient contrast based on scanning oblique back-scattering microscopy (sOBM). The probe consists of a 2.6mm-diameter micro-objective attached to a 30,000-core flexible fiber bundle. The dual contrasts are inherently co-registered, providing complementary information on labeled and un-labeled sample structure. Proof of principle demonstrations are presented with ex-vivo mouse colon tissue...
September 1, 2016: Biomedical Optics Express
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