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https://www.readbyqxmd.com/read/27903981/nurse-like-cells-promote-cll-survival-through-lfa-3-cd2-interactions
#1
Frédéric Boissard, Marie Tosolini, Laetitia Ligat, Anne Quillet-Mary, Frederic Lopez, Jean-Jacques Fournié, Loic Ysebaert, Mary Poupot
In the tumoral micro-environment (TME) of chronic lymphocytic leukemia (CLL), nurse-like cells (NLC) are tumor-associated macrophages which play a critical role in the survival and chemoresistance of tumoral cells. This pro-survival activity is known to involve soluble factors, but few data are available on the relative role of cells cross-talk. Here, we used a transcriptome-based approach to systematically investigate the expression of various receptor/ligand pairs at the surface of NLC/CLL cells. Their relative contribution to CLL survival was assessed both by fluorescent microscopy to identify cellular interactions and by the use of functional tests to measure the impact of uncoupling these pairs with blocking monoclonal antibodies...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27853646/hepatocellular-carcinoma-is-accelerated-by-nash-involving-m2-macrophage-polarization-mediated-by-hif-1%C3%AE-induced-il-10
#2
Aditya Ambade, Abhishek Satishchandran, Banishree Saha, Benedek Gyongyosi, Patrick Lowe, Karen Kodys, Donna Catalano, Gyongyi Szabo
Obesity-related inflammation promotes cancer development. Tissue resident macrophages affect tumor progression and the tumor micro-environment favors polarization into alternatively activated macrophages (M2) that facilitate tumor invasiveness. Here, we dissected the role of western diet-induced NASH in inducing macrophage polarization in a carcinogen initiated model of hepatocellular carcinoma (HCC). Adult C57BL/6 male mice received diethyl nitrosamine (DEN) followed by 24 weeks of high fat-high cholesterol-high sugar diet (HF-HC-HSD)...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27846403/magnetic-hyperthermia-enhances-cell-toxicity-with-respect-to-exogenous-heating
#3
Beatriz Sanz, M Pilar Calatayud, Teobaldo E Torres, Mónica L Fanarraga, M Ricardo Ibarra, Gerardo F Goya
Magnetic hyperthermia is a new type of cancer treatment designed for overcoming resistance to chemotherapy during the treatment of solid, inaccessible human tumors. The main challenge of this technology is increasing the local tumoral temperature with minimal side effects on the surrounding healthy tissue. This work consists of an in vitro study that compared the effect of hyperthermia in response to the application of exogenous heating (EHT) sources with the corresponding effect produced by magnetic hyperthermia (MHT) at the same target temperatures...
November 9, 2016: Biomaterials
https://www.readbyqxmd.com/read/27834402/macrophages-form-functional-vascular-mimicry-channels-in-vivo
#4
Faith H Barnett, Mauricio Rosenfeld, Malcolm Wood, William B Kiosses, Yoshihiko Usui, Valentina Marchetti, Edith Aguilar, Martin Friedlander
Macrophages, key cells of the innate immune system, are known to support angiogenesis but are not believed to directly form vessel walls. Here we show that macrophages structurally form primitive, NON-ENDOTHELIAL "vessels" or vascular mimicry (VM) channels in both tumor and angiogenesis in vivo models. These channels are functionally connected to the systemic vasculature as they are perfused by intravenously injected dye. Since both models share hypoxic micro-environments, we hypothesized that hypoxia may be an important mediator of VM formation...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825375/binding-of-galectin-1-to-breast-cancer-cells-mcf7-induces-apoptosis-and-inhibition-of-proliferation-in-vitro-in-a-2d-and-3d-cell-culture-model
#5
Pamina Geiger, Barbara Mayer, Irmi Wiest, Sandra Schulze, Udo Jeschke, Tobias Weissenbacher
BACKGROUND: Galectin-1 (gal-1) belongs to the family of β-galactoside-binding proteins which primarily recognizes the Galβ1-4GlcNAc sequences of oligosaccharides associated with several cell surface glycoconjugates. The lectin recognizes correspondent glycoepitopes on human breast cancer cells. Galectin-1 is expressed both in normal and malignant tissues. Lymphatic organs naturally possessing high rates of apoptotic cells, express high levels of Galectin-1. Furthermore galectin-1 can initiate T cell apoptosis...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27801609/persistence-to-anti-cancer-treatments-in-the-stationary-to-proliferating-transition
#6
Sivan Pearl Mizrahi, Orit Gefen, Itamar Simon, Nathalie Q Balaban
The heterogeneous responses of clonal cancer cells to treatment is understood to be caused by several factors, including stochasticity, cell-cycle dynamics, and different micro-environments. In a tumor, cancer cells may encounter fluctuating conditions and transit from a stationary culture to a proliferating state, for example this may occur following treatment. Here, we undertake a quantitative evaluation of the response of single cancerous lymphoblasts (L1210 cells) to various treatments administered during this transition...
November 1, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27784236/role-of-the-autonomic-nervous-system-in-the-tumor-micro-environment-and-its-therapeutic-potential
#7
Zhifang Xu, Seiji Shioda, Masahisa Jinushi, Yutaka Kawakami, Hirokazu Ohtaki, Shenjun Wang, Xue Zhao, Yangyang Liu, Dan Zhou, Yi Guo
Although evidence over the last 30 years suggests that the autonomic nervous system (ANS) mediates stress-induced allostatic and immune responses, the crucial role that it plays in the tumor micro-environment has only recently been reported. Here, we review the action of ANS signaling in this micro-environment. Emerging data suggest that primary tumors are innervated by the ANS which mediates stress-related effects on tumor progression. The activation of the sympathetic nervous system (SNS) takes advantage of neurotransmitters and neuropeptides from the innervating neural circuitry and/or hypothalamic-pituitary-adrenal axis glucocorticoids via their receptors to modulate the gene expression associated with oncogenesis, the proliferation and apoptosis of tumor cells, angiogenesis, and the tumor-associated immune response...
October 25, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27780661/high-intensity-focused-ultrasound-and-radiation-therapy-induced-immuno-modulation-comparison-and-potential-opportunities
#8
REVIEW
Roberta Cirincione, Federica Maria Di Maggio, Giusi Irma Forte, Luigi Minafra, Valentina Bravatà, Laura Castiglia, Vincenzo Cavalieri, Giovanni Borasi, Giorgio Russo, Domenico Lio, Cristina Messa, Maria Carla Gilardi, Francesco Paolo Cammarata
In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity...
October 22, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27777018/successful-derivation-of-xeno-free-mesenchymal-stem-cell-lines-from-endometrium-of-infertile-women
#9
Tatsanee Phermthai, Kittima Tungprasertpol, Suphakde Julavijitphong, Puttachart Pokathikorn, Sasiprapa Thongbopit, Suparat Wichitwiengrat
Transplantation of mesenchymal stem cells (MSC) can effectively repair endometrial deficiencies, including infertile patients with a problem of inadequate endometrium thickness. Although, MSC derived from different organ sources have a similarity of MSC specific characteristics, endometrial stem cells (EMSC) are temporally regulated throughout the menstrual cycle in a micro-environmental niche found only in endometrial tissue. Given the micro-environment niche, developing treatments for endometrial disorders with EMSC should be a top priority...
December 2016: Reproductive Biology
https://www.readbyqxmd.com/read/27739041/hypoxia-in-gliomas-opening-therapeutical-opportunities-using-a-mathematical-based-approach
#10
Alicia Martı Nez-González, Gabriel F Calvo, Jose M Ayuso, Ignacio Ochoa, Luis J Fernández, Víctor M Pérez-García
This chapter explores the use of mathematical models as promising and powerful tools to understand the complexity of tumors and their, frequently, hypoxic environment. We focus on gliomas, which are primary brain tumors derived from glial cells, mainly astrocytes and/or oligodendrocytes. A variety of mathematical models, based on ordinary and/or partial differential equations, have been developed both at the micro and macroscopic levels. The aim here is to describe in a quantitative way key physiopathological mechanisms relevant in these types of malignancies and to suggest optimal therapeutical strategies...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27708247/scriptaid-overcomes-hypoxia-induced-cisplatin-resistance-in-both-wild-type-and-mutant-p53-lung-cancer-cells
#11
Shrikant Pradhan, Divyank Mahajan, Prabhjot Kaur, Namita Pandey, Chandresh Sharma, Tapasya Srivastava
Non-small cell lung cancer (NSCLC), comprising 85% of lung cancer cases, has been associated with resistance to chemo/radiotherapy. The hypoxic tumor micro-environment, where insufficient vasculature results in poor drug penetrance and sub-optimal chemotherapy in the tumor interiors contributes heavily to this resistance. Additionally, epigenetic changes in tumorigenic cells also change their response to different forms of therapy. In our study, we have investigated the effectiveness of a combination of cisplatin with scriptaid [a pan-Histone Deacetylase inhibitor (HDACi)] in a model that mimics the tumor microenvironment of hypoxia and sub-lethal chemotherapy...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27672541/development-of-chidamide-for-peripheral-t-cell-lymphoma-the-first-orphan-drug-approved-in-china
#12
REVIEW
Xianping Lu, Zhiqiang Ning, Zhibin Li, Haixiang Cao, Xinhao Wang
Peripheral T-cell lymphoma (PTCL) is a set of rare and highly heterogeneous group of mature T- and NK-cell neoplasms associated with poor outcomes and lack of standard and effective therapies. The total number of newly diagnosed cases of PTCL yearly in China is estimated about 50,000. Chidamide (CS055) is a novel and orally active benzamide class of histone deacetylase (HDAC) inhibitor that selectively inhibits activity of HDAC1, 2, 3 and 10, the enzymes that are involved and play an important role in tumor initiation and development in both tumor cells and their surrounding micro-environment...
August 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27666556/-tumor-cells-and-micro-environment-in-brain-metastases
#13
Wen Zhong, Chengping Hu
Improvements in survival and quality of life of patients with lung cancer had been achieved due to the progression of early diagnosis and precision medicine at recent years, however, until now, treatments targeted at lesions in central nervous system are far from satisfying, thus threatening livelihood of patients involved. After all, in the issue of prophylaxis and therapeutics of brain metastases, it is crucial to learn about the biological behavior of tumor cells in brain metastases and its mechanism underlying, and the hypothesis "seed and soil", that is, tumor cells would generate series of adaptive changes to fit in the new environment, is liable to help explain this process well...
September 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27627810/generation-of-an-in%C3%A2-vitro-3d-pdac-stroma-rich-spheroid-model
#14
Matthew J Ware, Vazrik Keshishian, Justin J Law, Jason C Ho, Carlos A Favela, Paul Rees, Billie Smith, Sayeeduddin Mohammad, Rosa F Hwang, Kimal Rajapakshe, Cristian Coarfa, Shixia Huang, Dean P Edwards, Stuart J Corr, Biana Godin, Steven A Curley
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly required. Pancreatic stellate cells (PSC) are myofibroblast-like cells located in exocrine areas of the pancreas, which as a result of inflammation produced by PDAC migrate and accumulate in the tumor mass, secreting extracellular matrix components and producing the dense PDAC stroma...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27618112/neutrophils-and-granulocytic-mdsc-the-janus-god-of-cancer-immunotherapy
#15
REVIEW
Serena Zilio, Paolo Serafini
Neutrophils are the most abundant circulating blood cell type in humans, and are the first white blood cells recruited at the inflammation site where they orchestrate the initial immune response. Although their presence at the tumor site was recognized in the 1970s, until recently these cells have been neglected and considered to play just a neutral role in tumor progression. Indeed, in recent years neutrophils have been recognized to play a dual role in tumor development by either assisting the growth, angiogenesis, invasion, and metastasis or by exerting tumoricidal action directly via the secretion of antitumoral compounds, or indirectly via the orchestration of antitumor immunity...
September 9, 2016: Vaccines
https://www.readbyqxmd.com/read/27615180/-cancer-cell-plasticity-and-metastatic-dissemination
#16
Caroline Moyret-Lalle, Roxane Pommier, Charlotte Bouard, Ebticem Nouri, Geoffrey Richard, Alain Puisieux
Metastatic dissemination consists of a sequence of events resulting in the invasion by cancer cells of tissues located away from the primary tumour. This process is highly inefficient, since each event represents an obstacle that only a limited number of cells can overcome. However, two biological phenomena intrinsically linked with tumour development facilitate the dissemination of cancer cells throughout the body and promote the formation of metastases, namely the genetic diversity of cancer cells within a given tumour, which arises from their genetic instability and from successive clonal expansions, and cellular plasticity conveyed to the cells by micro-environmental signals...
August 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/27602763/expressions-of-cd8-tils-pd-l1-and-foxp3-tils-in-stage-i-nsclc-guiding-adjuvant-chemotherapy-decisions
#17
Feifei Teng, Xiangjiao Meng, Xin Wang, Jupeng Yuan, Sujing Liu, Dianbin Mu, Hui Zhu, Li Kong, Jinming Yu
PURPOSE: Currently, adjuvant chemotherapy is recommended for patients with high risk stage I non-small cell lung cancer (NSCLC). However, identifying high risk patients remains a challenge. This study aims to identify the patient cohorts more likely to benefit from adjuvant chemotherapy based on the tumor micro-immune environment. RESULTS: CD8+TILs significantly associated with disease-free survival (DFS) and overall survial (OS) (p=0.002; 0.040). Patients with high risk factors may also predict shorter DFS (P=0...
September 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27587198/genotype-or-phenotype-targeting-anticancer-therapies-lessons-from-tumor-evolutionary-biology
#18
Alexandre E Escargueil, Soizic Prado, Ambre Dezaire, Jean Clairambault, Annette K Larsen, Daniele G Soares
Despite the efficacy of most cancer therapies, drug resistance remains a major problem in the clinic. The eradication of the entire tumor and the cure of the patient by chemotherapy alone are rare, in particular for advanced disease. From an evolutionary perspective, the selective pressure exerted by chemotherapy leads to the emergence of resistant clones where resistance can be associated with many different functional mechanisms at the single cell level or can involve changes in the tumor micro-environment...
August 31, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27570561/the-clinical-significance-and-potential-therapeutic-role-of-gpx3-in-tumor-recurrence-after-liver-transplantation
#19
Xiang Qi, Kevin Tak-Pan Ng, Yan Shao, Chang Xian Li, Wei Geng, Chang Chun Ling, Yuen Yuen Ma, Xiao Bing Liu, Hui Liu, Jiang Liu, Wai Ho Yeung, Chung Mau Lo, Kwan Man
BACKGROUND AND AIMS: Our previous study showed that small-for-size liver graft may provide favorable micro-environment for tumor growth. GPx3, an anti-oxidant, not only attenuates oxidative stress, but also suppresses liver tumor growth in our recent study. Here, we aimed to characterize the clinical significance and explore the functional role of GPx3 in HCC recurrence after liver transplantation. METHODS: To explore the association between GPx3 expression and HCC invasiveness, a rat orthotopic liver transplantation model with tumor development was established...
2016: Theranostics
https://www.readbyqxmd.com/read/27552143/assessing-drug-efficacy-in-a-miniaturized-pancreatic-cancer-in-vitro-3d-cell-culture-model
#20
Todd B Shelper, Carrie J Lovitt, Vicky M Avery
Pancreatic cancer continues to have one of the poorest prognoses among all cancers. The drug discovery efforts for this disease have largely failed, with no significant improvement in survival outcomes for advanced pancreatic cancer patients over the past 20 years. Traditional in vitro cell culture techniques have been used extensively in both basic and early drug discovery; however, these systems offer poor models to assess emerging therapeutics. More predictive cell-based models, which better capture the cellular heterogeneity and complexities of solid pancreatic tumors, are urgently needed not only to improve drug discovery success but also to provide insight into the tumor biology...
September 2016: Assay and Drug Development Technologies
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