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https://www.readbyqxmd.com/read/28225152/topical-phenytoin-for-treating-pressure-ulcers
#1
REVIEW
Xiang Yong Hao, Hong Ling Li, He Su, Hui Cai, Tian Kang Guo, Ruifeng Liu, Lei Jiang, Yan Fei Shen
BACKGROUND: Pressure ulcers are common in clinical practice and pose a significant health problem worldwide. Apart from causing suffering to patients, they also result in longer hospital stays and increase the cost of health care. A variety of methods are used for treating pressure ulcers, including pressure relief, patient repositioning, biophysical strategies, nutritional supplementation, debridement, topical negative pressure, and local treatments including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28214397/a-case-of-iv-degree-on-acute-radiation-dermatitis-in-china
#2
Zhen Shen, Ya-Hong Chen, Yue Chen, Yan Chen, Zhe Lv, Hai-Cheng Gao
This report investigates the nursing procedure of a case of adjuvant therapy of rectal cancer on IV degree of acute radiation dermatitis patients in the penis and scrotum junction. The lesion degree gradually increased. Fixation of the dressing was difficult in the penis and scrotum junction. The concept of wet healing with new dressings was used in patient. The silver ion dressings were used in inhibiting infection, and the wound was covered by the rimmed foam dressings. When it comes to the shaping period, water gel transparent paste was applied instead to cover the wound...
February 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28163228/a-novel-in-situ-silver-hyaluronan-bio-nanocomposite-fabrics-for-wound-and-chronic-ulcer-dressing-in-vitro-and-in-vivo-evaluations
#3
A M Abdel-Mohsen, J Jancar, R M Abdel-Rahman, L Vojtek, P Hyršl, M Dušková, H Nejezchlebová
In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers/fabrics for the first time. Different concentrations of silver nitrate (1, 2mg/100ml) were added at ambient temperature to sodium hyaluronate solution (40mg/ml), then the pH was increased to 8 by adding sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers/nonwoven fabrics by wet-dry-spinning technique (WDST). UV/vis spectroscopy, SEM, TEM, DLS, XPS, XRD and TGA were employed to characterize the structure and composition of the nanocomposite, surface morphology of fiber/fabrics, particle size of Ag-NPs, chemical interactions of Ag(0) and HA functional groups, crystallinity and thermal stability of the wound dressing, respectively...
February 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28161149/a-systematic-review-and-meta-analysis-of-clinical-outcomes-associated-with-nanocrystalline-silver-use-compared-to-alternative-silver-delivery-systems-in-the-management-of-superficial-and-deep-partial-thickness-burns
#4
Leo M Nherera, Paul Trueman, Christopher D Roberts, Leena Berg
OBJECTIVE: The purpose of this systematic review and meta-analysis was to assess the clinical effectiveness of nanocrystalline silver compared to alternative silver delivery systems (silver sulphadiazine [SSD] and silver nitrate) in adults and children with superficial and deep partial thickness burns. METHODS: PubMed, EMBASE, Cochrane and other databases were searched to identify relevant randomised controlled trials and observational studies. RESULTS: Eight studies that assessed both nanocrystalline silver and SSD and one study that compared nanocrystalline silver vs...
February 1, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28157788/a-medical-mystery-unexplained-renal-failure-in-burn-patients
#5
Harrison M Lands, David B Drake
The objective of this study was to review the investigation that uncovered the medical mystery of burn patients developing unexpected renal failure. The authors examined published and unpublished manuscripts and case reports, as well as conducted personal interviews with primary sources. In the late 1970s, emergence of resistant bacterial strains to the topical antimicrobial silver sulfadiazine occurred at the University of Virginia Medical Center. In the search for an alternative topical antimicrobial with known coverage of Pseudomonas aeruginosa, Furacin Soluble Dressing was substituted...
January 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28108362/an-in-vitro-study-on-the-burn-wound-healing-activity-of-cotton-fabrics-incorporated-with-phytosynthesized-silver-nanoparticles-in-male-wistar-albino-rats
#6
Balashanmugam Pannerselvam, Mukesh Kumar Dharmalingam Jothinathan, Murugan Rajenderan, Palani Perumal, Kalaichelvan Pudupalayam Thangavelu, Hyung Joo Kim, Vijay Singh, Senthil Kumaran Rangarajulu
In modern therapeutics, chemically synthesized drugs have been reported as causing adverse effects including allergies, rashes, itches, and swelling. For the past few decades, silver nanoparticles (AgNPs) have widely been applied in medical domains due to their antimicrobial and wound healing properties. In the present study, different concentrations of phytosynthesized AgNPs-saturated cotton dress fabrics - in comparison to cotton fabrics treated with commercial ointment - were tested for 18days to assess their ability to speed the healing of rats' burn wounds...
January 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28060006/resolving-epibole-with-polymeric-membrane-dressings-in-home-care
#7
Kimberly S Bare, Jerri Drain
BACKGROUND: The management of chronic (nonhealing) wounds with epibole is challenging and costly, especially when the problem is not promptly identified or the patient is intolerant to conventional treatments. CASE DESCRIPTION: We describe the use of a polymeric membrane dressing (PMD) in 3 patients with chronic (nonhealing) wounds and epibole who were unable to be treated with traditional interventions such as silver nitrate or sharp debridement. Patient 1 was a 51 year-old male with a right foot stasis ulcer with 60% fibrin/slough to the wound bed, patient 2 was a 58-year-old female with a stage 4 pressure injury of the left hip with undermining, and patient 3 was a 62-year-old female with a dehisced abdominal surgical wound...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28040360/partial-thickness-scalds-in-children-a-comparison-of-different-treatment-strategies
#8
E de Graaf, M E van Baar, M G A Baartmans, S M H J Scholten-Jaegers, M K Nieuwenhuis, J Eshuis, J Hiddingh, G I J M Beerthuizen, C H van der Vlies
AIM: The aim of this study was to compare the clinical outcomes of different treatment strategies for children with partial-thickness scalds at two burn centers. At the first burn center, these burns were treated with a hydrofiber dressing (Aquacel(®), Convatec, Inc.(®), Princeton, NJ, USA) or silver sulfadiazine (SSD, Flammazine(®), Sinclair IS Pharma, London, UK Pharmaceuticals), while at the second burn center, cerium nitrate-silver sulfadiazine (CN-SSD, Flammacerium(®), Sinclair IS Pharma, London, UK Pharmaceuticals) was used...
December 28, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28025638/assessment-of-deep-partial-thickness-burn-treatment-with-keratin-biomaterial-hydrogels-in-a-swine-model
#9
D Poranki, C Goodwin, M Van Dyke
Partial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified), collagen hydrogel, or silver sulfadiazine (SSD)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28024533/using-chitosan-nanoparticles-as-drug-carriers-for-the-development-of-a-silver-sulfadiazine-wound-dressing
#10
Gina S El-Feky, Samar S Sharaf, Amira El Shafei, Aisha A Hegazy
Burn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. In the present study, a dressing coated with silver sulfadiazine (SSD) loaded chitosan nanoparticles (CSNPs) for the controlled-release of SSD into burn wound to control bacterial growth was investigated. CSNPs were formulated with different concentrations of chitosan and CM-β-CD and loaded with SSD complexed in 1:1 molar ratio with CM-β-CD, CSNPs were assessed for their particle size, polydispersity index, morphology and association efficiency...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27998108/one-pot-synthesis-of-biocompatible-silver-nanoparticle-composites-from-cellulose-and-keratin-characterization-and-antimicrobial-activity
#11
Chieu D Tran, Franja Prosenc, Mladen Franko, Gerald Benzi
A novel, simple method was developed to synthesize biocompatible composites containing 50% cellulose (CEL) and 50% keratin (KER) and silver in the form of either ionic (Ag(+)) or Ag(0) nanoparticles (Ag(+)NPs or Ag(0)NPs). In this method, butylmethylimmidazolium chloride ([BMIm(+)Cl(-)]), a simple ionic liquid, was used as the sole solvent and silver chloride was added to the [BMIm(+)Cl(-)] solution of [CEL+KER] during the dissolution process. The silver in the composites can be maintained as ionic silver (Ag(+)) or completely converted to metallic silver (Ag(0)) by reducing it with NaBH4...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27996083/dressings-for-the-prevention-of-surgical-site-infection
#12
REVIEW
Jo C Dumville, Trish A Gray, Catherine J Walter, Catherine A Sharp, Tamara Page, Rhiannon Macefield, Natalie Blencowe, Thomas Kg Milne, Barnaby C Reeves, Jane Blazeby
BACKGROUND: Surgical wounds (incisions) heal by primary intention when the wound edges are brought together and secured, often with sutures, staples, or clips. Wound dressings applied after wound closure may provide physical support, protection and absorb exudate. There are many different types of wound dressings available and wounds can also be left uncovered (exposed). Surgical site infection (SSI) is a common complication of wounds and this may be associated with using (or not using) dressings, or different types of dressing...
20, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27995588/fabrication-and-characterization-of-biosilver-nanoparticles-loaded-calcium-pectinate-nano-micro-dual-porous-antibacterial-wound-dressings
#13
Robin Augustine, Anitha Augustine, Nandakumar Kalarikkal, Sabu Thomas
Development of materials for medical applications using biologically derived materials by green approaches is emerging as an important focus in the present healthcare scenario. Herein the first time, we report the plant extract mediated ultra-rapid biosynthesis of silver nanoparticles using whole plant extracts of Biophytum sensitivum. Synthesized nanoparticles were immobilized in nano-micro dual-porous calcium pectinate scaffolds for wound dressing application. Pectinate wound dressings containing silver nanoparticles have shown excellent antibacterial property and exudate uptake capacity while being biocompatible to the human cells...
December 2016: Progress in biomaterials
https://www.readbyqxmd.com/read/27990437/enhanced-performance-and-mode-of-action-of-a-novel-antibiofilm-hydrofiber%C3%A2-wound-dressing
#14
David Parsons, Kate Meredith, Victoria J Rowlands, Darryl Short, Daniel G Metcalf, Philip G Bowler
Biofilm development in wounds is now acknowledged to be a precursor to infection and a cause of delayed healing. A next-generation antibiofilm carboxymethylcellulose silver-containing wound dressing (NGAD) has been developed to disrupt and kill biofilm microorganisms. This in vitro study aimed to compare its effectiveness against various existing wound dressings and examine its mode of action. A number of biofilm models of increasing complexity were used to culture biofilms of wound-relevant pathogens, before exposure to test dressings...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27987918/construction-of-silver-sulfadiazine-loaded-chitosan-composite-sponges-as-potential-wound-dressings
#15
Wei Shao, Jimin Wu, Shuxia Wang, Min Huang, Xiufeng Liu, Rui Zhang
Chitosan/silver sulfadiazine (CS/AgSD) composite sponges were prepared by incorporating AgSD particles into CS matrix in order to develop novel biomaterials for wound healing. The co-existence of CS and AgSD in the composite sponges was confirmed by SEM, FTIR and XRD spectra, respectively. The porosity and swelling properties of the fabricated CS/AgSD composite sponges were examined and the results indicated that they had high porosity and excellent swelling behaviors. Antibacterial property of the CS/AgSD composite sponges was also performed against E...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27987866/spongy-bilayer-dressing-composed-of-chitosan-ag-nanoparticles-and-chitosan-bletilla-striata-polysaccharide-for-wound-healing-applications
#16
Lang Ding, Xindi Shan, Xiaoliang Zhao, Hualian Zha, Xiaoyu Chen, Jianjun Wang, Chao Cai, Xiaojiang Wang, Guoyun Li, Jiejie Hao, Guangli Yu
The purpose of this study was to develop a promising wound dressing. Though chitosan cross-linked with genipin has been widely used as biomaterials, with the addition of partially oxidized Bletilla striata polysaccharide, the newly developed material in this study (coded as CSGB) showed less gelling time, more uniform aperture distribution, higher water retention, demanded mechanical strength and more L929 cell proliferation compared to the chitosan cross-linked only with genipin. Owning to partial blocking of free amino groups of chitosan, CSGB revealed almost no antibacterial activities, thus the bilayer composite of chitosan-silver nanoparticles (CS-AgG) on CSGB was designed to inhibit microbial invasion...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27974941/a-modern-method-of-treatment-the-role-of-silver-dressings-in-promoting-healing-and-preventing-pathological-scarring-in-patients-with-burn-wounds
#17
Munteanu A, Florescu Ip, Nitescu C
Burn wounds are a global public health problem, which affects all countries, no matter the development stage and occurs in all age groups, from toddlers to elderly. In spite of burns being the cause of numerous household and work accidents, there are still no clear stated unanimous rules for their treatment. Every day new products appear on the market, each of them trying to prove more effective. Since ancient times, silver has been known for its antimicrobial properties, so it has been used for a long time in the treatment of burns and other types of wounds...
July 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27974010/outcomes-of-acute-dermal-irritation-and-sensitisation-tests-on-active-dressings-for-chronic-wounds-a-comparative-study
#18
P J Zelga, M M Górnicz, J M Głuszkiewicz, J Piasecka-Zelga
OBJECTIVE: Chronic, non-healing ulcers are a significant problem in clinical practice. The numerous complications, associated with toxicological and allergic reactions, caused by certain compounds in active dressings have been reported. The aim of this study was to evaluate the local skin tolerance of active dressings and determine which of them carries a risk of causing local skin reactions. METHOD: We tested six active dressings from different categories (hydrogel dressing, chitosan sponge dressing, silver nanoparticles dressing, dry flax fibres dressing alone and coated with linfix or oilfix) for acute irritation in rabbits and for sensitisation in guinea pigs...
December 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27905181/effectiveness-of-collagen-oxidised-regenerated-cellulose-silver-containing-composite-wound-dressing-for-the-treatment-of-medium-depth-split-thickness-skin-graft-donor-site-wounds-in-multi-morbid-patients-a-prospective-non-comparative-single-centre-study
#19
Alexander Konstantinow, Tatjana V Fischer, Johannes Ring
Split-thickness skin grafting (STSG) is a widely used method in reconstructive surgery, but donor site wounds (DSWs) are often slow healing and painful. This prospective study evaluated the performance of a composite wound dressing containing collagen/oxidised regenerated cellulose in the treatment of medium-depth (0·4 mm) DSWs in 25 multi-morbid patients with chronic leg ulcers requiring STSG. The range of patients' ages was 44-84 years (mean 71·6 years) with DSW sizes ranging between 12 and 162 cm(2) (mean 78 cm(2) )...
December 1, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27901391/comparison-of-antibacterial-effects-among-three-foams-used-with-negative-pressure-wound-therapy-in-an-ex-vivo-equine-perfused-wound-model
#20
COMPARATIVE STUDY
Lore L Van Hecke, Maarten Haspeslagh, Katleen Hermans, Ann M Martens
OBJECTIVE To compare antibacterial effects among 3 types of foam used with negative-pressure wound therapy (NPWT) in an ex vivo equine perfused wound model. SAMPLES Abdominal musculocutaneous flaps from 6 equine cadavers. PROCEDURES Each musculocutaneous flap was continuously perfused with saline (0.9% NaCl) solution. Four 5-cm circular wounds were created in each flap and contaminated with 10(6) CFUs of both Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA). After a 1-hour incubation period, 1 of 4 treatments (NPWT with silver-impregnated polyurethane foam [NPWT-AgPU], polyurethane foam [NPWT-PU], or polyvinyl alcohol foam [NPWT-PVA] or a nonadherent dressing containing polyhexamethylene biguanide without NPWT [control]) was randomly applied to each wound...
December 2016: American Journal of Veterinary Research
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