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https://www.readbyqxmd.com/read/28339182/widespread-and-indiscriminate-nanosilver-use-genuine-potential-for-microbial-resistance
#1
Cindy Gunawan, Christopher P Marquis, Rose Amal, Georgios A Sotiriou, Scott A Rice, Elizabeth J Harry
In this era of increasing antibiotic resistance, the use of alternative antimicrobials such as silver has become more widespread. Superior antimicrobial activity has been provided through fabrication of silver nanoparticles or nanosilver (NAg), which imparts cytotoxic actions distinct from those of bulk silver. In the wake of the recent discoveries of bacterial resistance to NAg and its rising incorporation in medical and consumer goods such as wound dressings and dietary supplements, we argue that there is an urgent need to monitor the prevalence and spread of NAg microbial resistance...
March 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28335317/cytotoxicity-of-silver-nanoparticle-and-chitin-nanofiber-sheet-composites-caused-by-oxidative-stress
#2
Jun Kinoda, Masayuki Ishihara, Hidemi Hattori, Shingo Nakamura, Koichi Fukuda, Hidetaka Yokoe
Size-controlled spherical silver nanoparticles (<10 nm) and chitin-nanofiber sheet composites (Ag NPs/CNFS) have previously been reported to have strong antimicrobial activity in vitro. Although Ag NPs/CNFS have strong antimicrobial activity, their cytotoxicity has not been investigated. This study was performed to evaluate the effects of Ag NPs/CNFS on cytotoxicity for fibroblasts in vitro and healing delay of wound repair in vivo, focused on oxidative stress. Cytotoxic activities of Ag NPs/CNFS were investigated using a fibroblast cell proliferation assay, nitric oxide/nitrogen dioxide (NO/NO₂) measurement of the cell lysates in vitro, inhibitory effects of Ag NPs/CNFS on healing-impaired wound repair using diabetic mice in vivo, 8-hydroxy-2'-deoxyguanosine (8-OHdG) immunohistochemical staining of the skin sections, and generation of carbonyl protein in the wound was performed to evaluate cytotoxicity with oxidative stress...
October 20, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28325530/in-vitro-measurements-of-burn-dressing-adherence-and-the-effect-of-interventions-on-reducing-adherence
#3
Michal Brichacek, Chenxi Ning, Justin P Gawaziuk, Song Liu, Sarvesh Logsetty
PURPOSE: There is a paucity of research on reducing dressing adherence. This is partly due to lack of an in vitro model, recreating the clinical variability of wounds. Previously we described an in vitro gelatin model to evaluate adherence in a standardized manner. We present evaluation of strategies to reduce adherence in six dressings. PROCEDURES: Dressing materials used were: PET (Control), fine mesh gauze coated in bismuth and petroleum jelly (BIS), nanocrystalline silver (NS), wide mesh polyester coated in polysporin ointment (WM), fine mesh cellulose acetate coated in polysporin ointment (FM), and soft silicone mesh (SIL)...
March 18, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28315385/a-study-on-the-in-vitro-percutaneous-absorption-of-silver-nanoparticles-in-combination-with-aluminum-chloride-methyl-paraben-or-di-n-butyl-phthalate
#4
Katarzyna Domeradzka-Gajda, Marek Nocuń, Joanna Roszak, Beata Janasik, C Derrick Quarles, Wojciech Wąsowicz, Jarosław Grobelny, Emilia Tomaszewska, Grzegorz Celichowski, Katarzyna Ranoszek-Soliwoda, Małgorzata Cieślak, Dorota Puchowicz, Jhanis J Gonzalez, Richard E Russo, Maciej Stępnik
Some reports indicate that the silver released from dermally applied products containing silver nanoparticles (AgNP) (e.g. wound dressings or cosmetics) can penetrate the skin, particularly if damaged. AgNP were also shown to have cytotoxic and genotoxic activity. In the present study percutaneous absorption of AgNP of two different nominal sizes (Ag15nm or Ag45nm by STEM) and surface modification, i.e. citrate or PEG stabilized nanoparticles, in combination with cosmetic ingredients, i.e. aluminum chloride (AlCl3), methyl paraben (MPB), or di-n-butyl phthalate (DBPH) was assessed using in vitro model based on dermatomed pig skin...
March 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28288453/medical-treatment-of-tattoo-complications
#5
Jørgen Serup
Tattooing is a skin trauma and involves a special vulnus punctatum (with inserted tattoo ink, a vulnus venenatum), which should heal with no infection and no local complication. Local treatment in the healing phase ideally builds on the 'moist wound' principle using plastic film, hydrocolloids, silver dressing, and compression. Bacterial infections during healing are treated with oral antibiotics, and a list of first-line antibiotics is proposed. Notice is given to severe infections with affected general condition, and it is emphasized that intravenous antibiotic treatment must be instituted as early as possible to prevent septic shock and death...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28267679/the-effect-of-silver-coated-dressing-on-pain-management-and-hospitalization-duration-in-pediatric-partial-thickness-burns-a-retrospective-matched-cohort-study
#6
Itay Wiser, Ophir Schein, Julietta D Rubin, Roni Averbuch Sagie, Iris Reshef, Adi Lotan, Avshalom Shalom
OBJECTIVE: Daily burn wound dressing protocols elicit pain and anxiety, especially in pediatric burn patients. Novel dressing technologies reduce pain by obviating the need for frequent dressing changes. The objective of this study was to assess the effect of silver-coated dressings (SCDs) on pain management and outcomes in pediatric burn patients. MATERIALS AND METHODS: A retrospective, matched cohort study compared a SCD to standard dressing protocols in admitted pediatric burn patients...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28267490/facile-approach-for-large-scale-production-of-metal-and-metal-oxide-nanoparticles-and-preparation-of-antibacterial-cotton-pads
#7
Shiv Shankar, Jong-Whan Rhim
Metallic nanoparticles such as zinc oxide (ZnONPs), copper oxide (CuONPs), and silver (AgNPs) were synthesized in gram scale using green methods. The antibacterial cotton fibers/nanoparticles (cotton fibers/NPs) composite pads were prepared, and nanoparticle binding/release tests were performed. All the NPs were crystalline and showed characteristic XRD diffraction peaks and showed the characteristic FTIR bands of the respective nanoparticles. All the NPs showed strong antimicrobial activity against Gram-positive and Gram-negative pathogenic bacteria...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28251817/wound-management-of-ulcerated-haemangioma-of-infancy%C3%A2-%C3%A2-an-audit
#8
Zerina Lokmic, Taya Grainger, Nadeeja V Atapattu, Roderic J Phillips, Anthony J Penington
Haemangioma of infancy, a benign tumour of blood vessels, is the most common tumour of infancy. Ulceration, the most common complication, presents a unique wound care challenge. A retrospective audit of medical records of children with haemangioma of infancy who presented to the Royal Children's Hospital, Melbourne, Australia, between January 2000 and December 2014 was undertaken with an aim to examine wound management of ulcerated haemangioma of infancy. In total, 535 hospital medical records were identified as suitable, of which 352 were randomly selected and audited, of which 84 patients had ulcerated haemangioma of infancy, and 62 were subject to wound management...
March 1, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28239398/a-pilot-randomized-controlled-study-of-nanocrystalline-silver-manuka-honey-and-conventional-dressing-in-healing-diabetic-foot-ulcer
#9
Ka-Kit Tsang, Enid Wai-Yung Kwong, Tony Shing-Shun To, Joanne Wai-Yee Chung, Thomas Kwok-Shing Wong
Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups' design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28237574/cellulose-nanocomposite-films-with-in-situ-generated-silver-nanoparticles-using-cassia-alata-leaf-extract-as-a-reducing-agent
#10
P Sivaranjana, E R Nagarajan, N Rajini, M Jawaid, A Varada Rajulu
Cotton linters were dissolved in aq. (8% LiOH+15% urea) that was pre-cooled to -12.5°C. Using this solution cellulose gel films were prepared by regeneration method with ethyl alcohol as a coagulant. These wet films were diffused with 10wt% Cassia alata leaf extract that acted as a reducing agent. The leaf extract diffused cellulose wet films were used as the matrix. The wet matrix films were dipped individually in lower concentrated 1-5mM aq.AgNO3 source solutions in the presence of sunlight and allowed the solutions to react with the diffused leaf extract reducing agent which in situ generated the silver nanoparticles (AgNPs) inside the films as well as in the source solution...
February 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28225152/topical-phenytoin-for-treating-pressure-ulcers
#11
REVIEW
Xiang Yong Hao, Hong Ling Li, He Su, Hui Cai, Tian Kang Guo, Ruifeng Liu, Lei Jiang, Yan Fei Shen
BACKGROUND: Pressure ulcers are common in clinical practice and pose a significant health problem worldwide. Apart from causing suffering to patients, they also result in longer hospital stays and increase the cost of health care. A variety of methods are used for treating pressure ulcers, including pressure relief, patient repositioning, biophysical strategies, nutritional supplementation, debridement, topical negative pressure, and local treatments including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28214397/a-case-of-iv-degree-on-acute-radiation-dermatitis-in-china
#12
Zhen Shen, Ya-Hong Chen, Yue Chen, Yan Chen, Zhe Lv, Hai-Cheng Gao
This report investigates the nursing procedure of a case of adjuvant therapy of rectal cancer on IV degree of acute radiation dermatitis patients in the penis and scrotum junction. The lesion degree gradually increased. Fixation of the dressing was difficult in the penis and scrotum junction. The concept of wet healing with new dressings was used in patient. The silver ion dressings were used in inhibiting infection, and the wound was covered by the rimmed foam dressings. When it comes to the shaping period, water gel transparent paste was applied instead to cover the wound...
February 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28163228/a-novel-in-situ-silver-hyaluronan-bio-nanocomposite-fabrics-for-wound-and-chronic-ulcer-dressing-in-vitro-and-in-vivo-evaluations
#13
A M Abdel-Mohsen, J Jancar, R M Abdel-Rahman, L Vojtek, P Hyršl, M Dušková, H Nejezchlebová
In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers/fabrics for the first time. Different concentrations of silver nitrate (1, 2mg/100ml) were added at ambient temperature to sodium hyaluronate solution (40mg/ml), then the pH was increased to 8 by adding sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers/nonwoven fabrics by wet-dry-spinning technique (WDST). UV/vis spectroscopy, SEM, TEM, DLS, XPS, XRD and TGA were employed to characterize the structure and composition of the nanocomposite, surface morphology of fiber/fabrics, particle size of Ag-NPs, chemical interactions of Ag(0) and HA functional groups, crystallinity and thermal stability of the wound dressing, respectively...
February 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28161149/a-systematic-review-and-meta-analysis-of-clinical-outcomes-associated-with-nanocrystalline-silver-use-compared-to-alternative-silver-delivery-systems-in-the-management-of-superficial-and-deep-partial-thickness-burns
#14
Leo M Nherera, Paul Trueman, Christopher D Roberts, Leena Berg
OBJECTIVE: The purpose of this systematic review and meta-analysis was to assess the clinical effectiveness of nanocrystalline silver compared to alternative silver delivery systems (silver sulphadiazine [SSD] and silver nitrate) in adults and children with superficial and deep partial thickness burns. METHODS: PubMed, EMBASE, Cochrane and other databases were searched to identify relevant randomised controlled trials and observational studies. RESULTS: Eight studies that assessed both nanocrystalline silver and SSD and one study that compared nanocrystalline silver vs...
February 1, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28157788/a-medical-mystery-unexplained-renal-failure-in-burn-patients
#15
Harrison M Lands, David B Drake
The objective of this study was to review the investigation that uncovered the medical mystery of burn patients developing unexpected renal failure. The authors examined published and unpublished manuscripts and case reports, as well as conducted personal interviews with primary sources. In the late 1970s, emergence of resistant bacterial strains to the topical antimicrobial silver sulfadiazine occurred at the University of Virginia Medical Center. In the search for an alternative topical antimicrobial with known coverage of Pseudomonas aeruginosa, Furacin Soluble Dressing was substituted...
January 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28108362/an-in-vitro-study-on-the-burn-wound-healing-activity-of-cotton-fabrics-incorporated-with-phytosynthesized-silver-nanoparticles-in-male-wistar-albino-rats
#16
Balashanmugam Pannerselvam, Mukesh Kumar Dharmalingam Jothinathan, Murugan Rajenderan, Palani Perumal, Kalaichelvan Pudupalayam Thangavelu, Hyung Joo Kim, Vijay Singh, Senthil Kumaran Rangarajulu
In modern therapeutics, chemically synthesized drugs have been reported as causing adverse effects including allergies, rashes, itches, and swelling. For the past few decades, silver nanoparticles (AgNPs) have widely been applied in medical domains due to their antimicrobial and wound healing properties. In the present study, different concentrations of phytosynthesized AgNPs-saturated cotton dress fabrics - in comparison to cotton fabrics treated with commercial ointment - were tested for 18days to assess their ability to speed the healing of rats' burn wounds...
March 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28060006/resolving-epibole-with-polymeric-membrane-dressings-in-home-care
#17
Kimberly S Bare, Jerri Drain
BACKGROUND: The management of chronic (nonhealing) wounds with epibole is challenging and costly, especially when the problem is not promptly identified or the patient is intolerant to conventional treatments. CASE DESCRIPTION: We describe the use of a polymeric membrane dressing (PMD) in 3 patients with chronic (nonhealing) wounds and epibole who were unable to be treated with traditional interventions such as silver nitrate or sharp debridement. Patient 1 was a 51 year-old male with a right foot stasis ulcer with 60% fibrin/slough to the wound bed, patient 2 was a 58-year-old female with a stage 4 pressure injury of the left hip with undermining, and patient 3 was a 62-year-old female with a dehisced abdominal surgical wound...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28040360/partial-thickness-scalds-in-children-a-comparison-of-different-treatment-strategies
#18
E de Graaf, M E van Baar, M G A Baartmans, S M H J Scholten-Jaegers, M K Nieuwenhuis, J Eshuis, J Hiddingh, G I J M Beerthuizen, C H van der Vlies
AIM: The aim of this study was to compare the clinical outcomes of different treatment strategies for children with partial-thickness scalds at two burn centers. At the first burn center, these burns were treated with a hydrofiber dressing (Aquacel(®), Convatec, Inc.(®), Princeton, NJ, USA) or silver sulfadiazine (SSD, Flammazine(®), Sinclair IS Pharma, London, UK Pharmaceuticals), while at the second burn center, cerium nitrate-silver sulfadiazine (CN-SSD, Flammacerium(®), Sinclair IS Pharma, London, UK Pharmaceuticals) was used...
December 28, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28025638/assessment-of-deep-partial-thickness-burn-treatment-with-keratin-biomaterial-hydrogels-in-a-swine-model
#19
D Poranki, C Goodwin, M Van Dyke
Partial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified), collagen hydrogel, or silver sulfadiazine (SSD)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28024533/using-chitosan-nanoparticles-as-drug-carriers-for-the-development-of-a-silver-sulfadiazine-wound-dressing
#20
Gina S El-Feky, Samar S Sharaf, Amira El Shafei, Aisha A Hegazy
Burn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. In the present study, a dressing coated with silver sulfadiazine (SSD) loaded chitosan nanoparticles (CSNPs) for the controlled-release of SSD into burn wound to control bacterial growth was investigated. CSNPs were formulated with different concentrations of chitosan and CM-β-CD and loaded with SSD complexed in 1:1 molar ratio with CM-β-CD, CSNPs were assessed for their particle size, polydispersity index, morphology and association efficiency...
February 20, 2017: Carbohydrate Polymers
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