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https://www.readbyqxmd.com/read/29663928/a-tiered-experimental-approach-for-characterization-and-silver-release-of-silver-containing-wound-dressings
#1
Liming Xu, Ru Bai, Xiang Cheng, Anliang Shao, Liang Chen, Shuxin Qu, Chunying Chen
Silver-containing dressings are widely used for wound care owing to their broad-spectrum microbicidal activity. However, the potential adverse effects on human health emerging from exposure to their active ingredients (silver ions or nanoparticles) have resulted in widespread concerns about their use. The release profiles of various chemical forms of silver (Ag) from silver-containing dressing are closely related to their bioavailability and potential adverse effects on the body. In this research, we demonstrated a tiered experimental approach for systematic characterization and assessment of silver-containing wound dressing, which provides information for risk assessments...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29627463/recent-advances-on-silver-nanoparticle-and-biopolymer-based-biomaterials-for-wound-healing-applications
#2
REVIEW
Sathish Sundar Dhilip Kumar, Naresh Kumar Rajendran, Nicolette Nadene Houreld, Heidi Abrahamse
Silver nanoparticles (AgNPs) are classified as metal-based nanoparticles and have gained considerable attention amongst researchers in wound healing applications, owing to their physicochemical and biological properties. The effectiveness of AgNPs has been tested in vitro and are well documented in the literature. Silver nanoparticles have been shown to possess fast, broad-spectrum antibacterial activity. Dressings which contain AgNPs are non-cytotoxic and safe for patients in wound care management. Silver nanoparticle based biomaterials (AgNP-BMs) are actively utilized for the treatment of all types of chronic wounds, and this combination plays an important role in wound healing applications...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29596934/a-non-woven-fabric-wound-dressing-containing-layer-by-layer-deposited-hyaluronic-acid-and-chitosan
#3
H M Fahmy, A A Aly, A Abou-Okeil
Novel wound dressings composed of non-woven cotton (NWC) fabric and multilayer of hyaluronan (HA) and chitosan were built using layer-by-layer assembly technique. Factors affecting the building up of that dressings such as HA concentration, number of coating layers and nitrogen content of the NWC fabric quaternized form were studied. Meanwhile, some physico-chemical properties of such dressings were investigated. Moreover, to enhance the antibacterial properties of the aforementioned dressings, Silver nano-particles (Ag NPs) were prepared and incorporated as a functional additive in the final HA layer of such dressings...
March 26, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29595705/treatment-of-partial-thickness-hand-burn-injuries-in-children-with-combination-of-silver-foam-dressing-and-zinc-hyaluronic-gel-case-reports
#4
Gergo Jozsa, Peter Vajda, Andras Garami, Alexandra Csenkey, Zsolt Juhasz
RATIONALE: Burns is a common type of traumatic injury in childhood. Nowadays, several wound dressings are available to treat the second-degree hand burns conservatively. PATIENT CONCERNS, DIAGNOSES: At the authors' institute, 37 children were treated conservatively with a special dressing at first intervention containing Aquacel Ag foam and Zn-hyaluronic gel to determine their effectiveness on partial thickness hand burns. INTERVENTIONS: The dressing was checked on the second day, and removed on the sixth or seventh day (unless it had spontaneously separated)...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29584609/a-scoping-review-of-the-use-of-silver-impregnated-dressings-for-the-treatment-of-chronic-wounds
#5
Jimena Rodriguez-Arguello, Karin Lienhard, Pooja Patel, Rose Geransar, Ranjani Somayaji, Laurie Parsons, John Conly, Chester Ho
Topical silver agents and dressings are used to control infection and promote healing in chronic wounds, but reviews published from 2006 to 2011 found heterogeneous results regarding their effectiveness. A scoping review was conducted to examine the extent, range, and nature of research activity surrounding chronic wound care that employed silver-impregnated dressings; identify research gaps in the existing literature; and summarize the evidence to provide recommendations for future clinical studies. Ten (10) electronic databases and additional sources were screened from their inception to May 2016; search terms for the different databases included but were not limited to silver, chronic, complications, wound, ulcer, and sore...
March 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29581004/preparation-of-biocompatible-and-biodegradable-silk-fibroin-chitin-silver-nanoparticles-3d-scaffolds-as-a-bandage-for-antimicrobial-wound-dressing
#6
Mojtaba Ghanbari Mehrabani, Ramin Karimian, Bahareh Mehramouz, Mahdi Rahimi, Hossein Samadi Kafil
One of the most serious challenge in wound care is difficulty of the infection control in wound healing process. Wound dressings with antimicrobial effects are useful to minimize the bacterial infections of wounds. In this study a biocompatible and biodegradable silk fibroin/chitin nanocomposite scaffolds with various content of silver nanoparticles (0.001, 0.01, and 0.1%) were fabricated via freeze-drying method for successful wound dressing application. The nanocomposite scaffolds have biocompatibility with high antimicrobial effects, good mechanical properties, and high porosity...
March 23, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29564863/-nursing-care-experiences-of-periwound-moisture-associated-dermatitis-after-simultaneous-pancreas-kidney-transplantation
#7
Pei-Ying Yeh, Hsiao-Ping Chen, Jing-Yi Wu
Simultaneous pancreas-kidney (SPK) transplantation is the primary surgical treatment for type I diabetes mellitus with end-stage renal disease. However, this transplant surgery has a high-risk of surgical complications, including duodenal anastomotic leakage, which may lead to pancreas transplantation failure if the leakage worsens. This case report describes a patient who suffered from duodenal anastomotic leakage after SPK transplantation. The digestive enzymes eroded the wound and skin around the wound, resulting in periwound moisture-associated dermatitis...
April 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29529703/antimicrobial-efficacy-of-a-silver-impregnated-hydrophilic-pu-foam
#8
Steven L Percival
A novel hydrophilic polyurethane (PU) foam dressing which is impregnated with silver chloride, Optifoam® Gentle (OG) Ag+ (Medline Industries Inc., Chicago, Illinois), was evaluated in this study. The aims of this study were to determine the rate of elution of silver from the foam dressing over a period of 168 hours into simulated wound fluid and an evaluation of antimicrobial efficacy using zone of inhibition (ZOI), direct kill, and time-kill viability. Thirty-two microorganisms associated with wounds including Pseudomonas aeruginosa, Methicillin sensitive Staphylococcus aureus (MSSA), Acinetobacter baumannii, Candida albicans, and antibiotic-resistant strains (Methicillin-resistant S...
March 12, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29528167/silver-oxysalts-promote-cutaneous-wound-healing-independent-of-infection
#9
Helen A Thomason, Jodie M Lovett, Carla J Spina, Christian Stephenson, Andrew J McBain, Matthew J Hardman
Chronic wounds often exist in a heightened state of inflammation whereby excessive inflammatory cells release high levels of proteases and reactive oxygen species (ROS). While low levels of ROS play a fundamental role in the regulation of normal wound healing, their levels need to be tightly regulated to prevent a hostile wound environment resulting from excessive levels of ROS. Infection amplifies the inflammatory response, augmenting levels of ROS which creates additional tissue damage that supports microbial growth...
March 12, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29521644/cost-effectiveness-analysis-of-silver-delivery-approaches-in-the-management-of-partial-thickness-burns
#10
Leo Nherera, Paul Trueman, Christopher Roberts, Leena Berg
INTRODUCTION: Burn injury is a common type of traumatic injury that causes considerable morbidity and mortality, resulting in about 30,000 admissions annually in specialist burn centers and costing around $1 billion per year in the United States. One percent silver sulfadiazine has been utilized widely in the management of burns and newer silver dressings are on the market, including nanocrystalline silver dressings, silver-impregnated hydrofiber dressings, and silver-impregnated foam dressings...
February 23, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29519568/dressed-for-success-silver-impregnated-nanocrystalline-dressing-for-initial-treatment-of-giant-omphalocele
#11
Dean B Percy, Candace Haddock, Vivian Ma, Amie Nowak, Julia Panczuk, Sonia Butterworth
OBJECTIVE: The purpose of this study was to describe outcomes and resource utilization in patients treated with twice-weekly silver impregnated (SI) nanocrystalline dressings for initial non-operative management of giant omphalocele (GO). METHODS: A retrospective review of patients with GO treated with SI dressings was undertaken. Clinical parameters, cost, and complications were recorded. RESULTS: Five patients with GO were treated with SI dressings between 2014 and 2016...
February 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29508105/decellularized-amnion-scaffold-with-activated-prp-a-new-paradigm-dressing-material-for-burn-wound-healing
#12
Jeevitaa Kshersagar, Ravi Kshirsagar, Shashikant Desai, Raghvendra Bohara, Meghnad Joshi
Direct application of amnion has greater risk of immunological rejection and infection. Decellularization is an effective method to lower the risk of immune complications and infections. The bioreactor assembly with multiple cassettes was designed for decellurization of multiple amnions with different cell types simultaneously in single run. A detergent-based protocol was modified to remove all cellular components from amnion and diminish the DNA content to render it non-immunogenic. Amnion (n = 10) were treated with 2% sodium dodecyl sulphate (SDS), 5% dimethyl sulfoxide (DMSO) and 2% sodium deoxycholeate (SD)...
March 5, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29505121/detection-and-function-of-lipopolysaccharide-and-its-purified-lipid-a-after-treatment-with-auxiliary-chemical-substances-and-calcium-hydroxide-dressings-used-in-root-canal-treatment
#13
A C S Marinho, T T To, R P Darveau, B P F A Gomes
AIM: To investigate the influence of auxiliary chemical substances (ACS) and calcium hydroxide [Ca(OH)2 ] dressings on LPS/lipid A detection and its functional ability in activating Toll-like receptor 4 (TLR4). METHODOLOGY: Fusobacterium nucleatum pellets were exposed to antimicrobial agents as following: 1) ACS: 5.25%, 2.5% and 1% sodium hypochlorite solutions (NaOCl), 2% chlorhexidine (CHX) (gel and solution) and 17% ethylenediaminetetraacetic acid (EDTA); 2) Intracanal medicament: Ca(OH)2 paste for various periods (1h, 24h, 7 days, 14 days and 30 days); 3) Combination of substances: a) 2...
March 5, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29471089/facile-green-and-scalable-method-to-produce-carrageenan-based-hydrogel-containing-in-situ-synthesized-agnps-for-application-as-wound-dressing
#14
Karine Modolon Zepon, Morgana Souza Marques, Marcos Marques da Silva Paula, Fernando Dal Pont Morisso, Luiz Alberto Kanis
This manuscript was focused on introducing a facile, green and scalable method to produce kappa-carrageenan (κC) hydrogel membranes containing in situ synthesized silver nanoparticles (AgNPs). In a typical protocol, κC hydrogels were obtained by heating (sol phase), followed by cooling (gel phase) the polysaccharide solution, which enabled the simultaneous synthesis of AgNPs during the heating time. The as synthesized AgNPs were characterized spectrophotometrically, and by dynamic light scattering and transmission electron microscopy...
February 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29463162/comparative-in-vivo-evaluation-of-novel-formulations-based-on-alginate-and-silver-nanoparticles-for-wound-treatments
#15
Jasmina Stojkovska, Zeljka Djurdjevic, Ivan Jancic, Biljana Bufan, Marina Milenkovic, Radmila Jankovic, Vesna Miskovic-Stankovic, Bojana Obradovic
In the present study, possibilities for using novel nanocomposites based on alginate and silver nanoparticles for wound treatment were investigated in a second-degree thermal burn model in Wistar rats. Silver nanoparticles (AgNPs) were electrochemically synthesized in alginate solutions that were further utilized to obtain the Ag/alginate solution and microfibers for subsequent in vivo studies. Daily applications of the Ag/alginate colloid solution, containing AgNPs, alginate and ascorbic acid (G3), wet Ag/alginate microfibers containing AgNPs (G5) and dry Ag/alginate microfibers containing AgNPs (G6) were compared to treatments with a commercial cream containing silver sulfadiazine (G2) and a commercial Ca-alginate wound dressing containing silver ions (G4), as well as to the untreated controls (G1)...
January 1, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29462690/xpf-plays-an-indispensable-role-in-relieving-silver-nanoparticle-induced-dna-damage-stress-in-human-cells
#16
Dan Wang, Huali Yang, Zheng Zhou, Man Zhao, Runsheng Chen, Simon H Reed
Due to the specific antimicrobial activity of silver nanoparticles (AgNPs), they are widely used in wound dressings, coatings in medical devices and household products. In spite of the well-documented genotoxicity of AgNPs, the molecular mechanisms of relieving AgNP-induced DNA damage stress remain poorly understood. We report here that one of the DNA repair factors, XPF, plays a crucial role in resisting AgNP-induced DNA damage stress in human cells. Following culture with AgNP-containing media, severely decreased colony forming abilities have been observed in XPF mutant and knockdown cells compared with wild type or control cells respectively, demonstrating that XPF is required to resist the AgNP-induced stress...
February 17, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29425164/association-of-alpha-tocopherol-and-ag-sulfadiazine-chitosan-oleate-nanocarriers-in-bioactive-dressings-supporting-platelet-lysate-application-to-skin-wounds
#17
Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Eleonora Dellera, Alessandro Invernizzi, Cinzia Boselli, Antonia Icaro Cornaglia, Claudia Del Fante, Cesare Perotti, Barbara Vigani, Federica Riva, Carla Caramella, Franca Ferrari
Chitosan oleate was previously proposed to encapsulate in nanocarriers some poorly soluble molecules aimed to wound therapy, such as the anti-infective silver sulfadiazine, and the antioxidant α tocopherol. Because nanocarriers need a suitable formulation to be administered to wounds, in the present paper, these previously developed nanocarriers were loaded into freeze dried dressings based on chitosan glutamate. These were proposed as bioactive dressings aimed to support the application to wounds of platelet lysate, a hemoderivative rich in growth factors...
February 9, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29424642/restoring-balance-biofilms-and-wound-dressings
#18
Steven L Percival
Biofilms are responsible for stimulating and maintaining wound inflammation, increasing infection risk and delaying wound closure. Appropriate biofilm management is required to fight against local and systemic infection and to restore balance to the wound environment. The most effective way to remove biofilms involves the use of mechanical techniques, with the wound dressing representing an important component of this strategy. Wound dressing fibres, such as polyacrylate fibres, have been shown to be effective in affecting biofilm architecture by disrupting the biofilm matrix...
February 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29396683/alginate-membranes-loaded-with-hyaluronic-acid-and-silver-nanoparticles-to-foster-tissue-healing-and-to-control-bacterial-contamination-of-non-healing-wounds
#19
Lorena Tarusha, Sergio Paoletti, Andrea Travan, Eleonora Marsich
Chronic non-healing wounds are a clinically important problem in terms of number of patients and costs. Wound dressings such as hydrogels, hydrocolloids, polyurethane films and foams are commonly used to manage these wounds since they tend to maintain a moist environment which is shown to accelerate re-epithelialization. The use of antibacterial compounds is important in the management of wound infections. A novel wound-dressing material based on a blended matrix of the polysaccharides alginate, hyaluronic acid and Chitlac-silver nanoparticles is here proposed and its application for wound healing is examined...
February 2, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29391092/outcomes-of-unroofing-with-limited-excision-and-structured-postoperative-care-for-pilonidal-disease
#20
Farees Ricky Tavangari, Jennifer Amy Lee, David Garza, Talar Tejirian
Despite a wide variety of surgical techniques to treat chronic pilonidal disease, high rates of recurrence are common. The current study analyzes the outcome of unroofing with limited excision combined with structured postoperative wound care for pilonidal disease. We performed a retrospective review of all patients who were treated with this technique over a seven year period. Ninety-four patients aged 11 to 63 (mean age 26) received this treatment for pilonidal disease. Eighty-nine patients were treated for primary pilonidal disease and five were treated for recurrent disease after procedures such as flaps...
October 1, 2017: American Surgeon
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