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https://www.readbyqxmd.com/read/28804527/synthesis-and-characterisation-of-cross-linked-chitosan-composites-functionalised-with-silver-and-gold-nanoparticles-for-antimicrobial-applications
#1
Catherine Ryan, Emma Alcock, Finbarr Buttimer, Michael Schmidt, David Clarke, Martyn Pemble, Maria Bardosova
We present a study of a range of cross-linked chitosan composites with potential antimicrobial applications. They were formed by cross-linking chitosan and siloxane networks and by introducing silver and gold nanoparticles (NPs). The aim was to investigate whether adding the metal NPs to the chitosan-siloxane composite would lead to a material with enhanced antimicrobial ability as compared to chitosan itself. The composites were synthesised in hydrogel form with the metal NPs embedded in the cross-linked chitosan network...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28782570/nanomedicine-and-advanced-technologies-for-burns-preventing-infection-and-facilitating-wound-healing
#2
Mirza Ali Mofazzal Jahromi, Parham Sahandi Zangabad, Seyed Masoud Moosavi Basri, Keyvan Sahandi Zangabad, Ameneh Ghamarypour, Amir R Aref, Mahdi Karimi, Michael R Hamblin
According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections...
August 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28781137/bioimpedance-spectroscopy-a-technique-to-monitor-interventions-for-swelling-in-minor-burns
#3
Pippa Kenworthy, Tiffany L Grisbrook, Michael Phillips, Paul Gittings, Fiona M Wood, William Gibson, Dale W Edgar
The control of edema in burn injured patients is a priority as it can impede the wound healing process. Bioimpedance spectroscopy (BIS) has been identified as a method of swelling assessment that has merit after burns. The aim of this study was to examine the reliability and validity of BIS in the measurement of localised burn wound edema across (1) different dressing conditions (no dressing, non silver and silver dressings) and (2) three electrode positions. BIS resistance (R) was hypothesised to be inversely proportional to fluid (edema) volume...
August 3, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28771993/a-pegylated-fibrin-hydrogel-based-antimicrobial-wound-dressing-controls-infection-without-impeding-wound-healing
#4
Joel Gil, Shanmugasundaram Natesan, Jie Li, Jose Valdes, Andrew Harding, Michael Solis, Stephen C Davis, Robert J Christy
Combat injuries are associated with a high incidence of infection, and there is a continuing need for improved approaches to control infection and promote wound healing. Due to the possible local and systemic adverse effects of standard 1% cream formulation (Silvadene), we had previously developed a polyethylene glycol (PEGylated) fibrin hydrogel (FPEG)-based wound dressing for the controlled delivery of silver sulfadiazine (SSD) entrapped in chitosan microspheres (CSM). In this study, we have evaluated the antimicrobial and wound healing efficacy of SSD-CSM-FPEG using a full-thickness porcine wound infected with Pseudomonas aeruginosa...
August 2, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28763910/-influence-of-different-inner-dressings-in-negative-pressure-wound-therapy-on-escharectomy-wound-of-full-thickness-burn-rabbits
#5
J H Lin, J Chen, D J Xue, W X Huang, G L Su
Objective: To explore the influence of different inner dressings in negative-pressure wound therapy (NPWT) on escharectomy wound of full-thickness burn rabbits. Methods: Eighteen Japanese white rabbits were inflicted with full-thickness burn on unilateral back. They were divided into polymer dressing group (PD), biological dressing group (BD), and silver biological dressing group (SBD), according to the random number table, with 6 rabbits in each group. On 3 days post burn, the wounds were performed with escharectomy, and then wounds of rabbits in group PD were covered with polyurethane foam...
July 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28757422/combined-antibacterial-tissue-regeneration-response-in-thermal-burns-promoted-by-functional-chitosan-silver-nanocomposites
#6
E Luna-Hernández, M E Cruz-Soto, F Padilla-Vaca, R A Mauricio-Sánchez, D Ramirez-Wong, R Muñoz, L Granados-López, L R Ovalle-Flores, J L Menchaca-Arredondo, A Hernández-Rangel, E Prokhorov, J L García-Rivas, B L España-Sánchez, G Luna-Bárcenas
We report the combined antibacterial/tissue regeneration responses to thermal burns promoted by functional chitosan/silver nanocomposites (CS/nAg) with ultralow silver content (0.018wt.%, 7-30nm). Our approach allows one to produce CS/nAg nanocomposites without silver nanoparticles (nAg) agglomeration, with bactericide potency higher than 1wt.% of nAg (ca. 10nm) content and, promoting the healing process in controlled thermal burns. CS/nAg films exhibit high antibacterial activity against S. aureus and P. aeruginosa after 1...
July 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28750575/creation-and-evaluation-of-new-porcine-model-for-investigation-of-treatments-of-surgical-site-infection
#7
Mahsa Mohiti-Asli, Marije Risselada, Megan Jacob, Behnam Pourdeyhimi, Elizabeth Loboa
Surgical site infection (SSI) is the most common cause of surgical failure, increasing the risks of postoperative mortality and morbidity. Recently, it has been reported that the use of antimicrobial dressings at the incision site help with prevention of SSI. Despite the increased body of research on the development of different types of antimicrobial dressings for this application, to our knowledge nobody has reported a reliable large animal model to evaluate the efficacy of developed materials in a preclinical SSI model...
July 27, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28745283/fabrication-of-biopolymer-based-nanocomposite-wound-dressing-evaluation-of-wound-healing-properties-and-wound-microbial-load
#8
Ali Es-Haghi, Mohammad Mashreghi, Mahere Rezazade Bazaz, Masoud Homayouni-Tabrizi, Majid Darroudi
The aim of this study is to introduce natural-based polymers, chitosan and starch, to design a remedial nanocomposite, comprising of cerium oxide nanoparticles and silver nanoparticles, to investigate their effects in accelerating wound healing and in wound microbial load. Cerium oxide nanoparticles synthesized in starch solution added to the colloidal dispersion of synthesized silver nanoparticles in chitosan to make a three-component nanomaterial. Mice were anaesthetized and two parallel full-thickness round wounds were excised under aseptic conditions with the help of sterile dermal biopsy punch...
August 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28742235/silver-delivery-approaches-in-the-management-of-partial-thickness-burns-a-systematic-review-and-indirect-treatment-comparison
#9
Leo Nherera, Paul Trueman, Christopher Roberts, Leena Berg
Silver-containing products play an important role in the management of burn wound infections. We sought to compare the efficacy of commonly used silver delivery approaches including nanocrystalline silver, silver-impregnated hydrofiber dressing, and silver-impregnated foam dressing as the main products in the management of partial thickness burns. A systematic review was performed by searching PubMed, EMBASE, Cochrane and other databases to identify relevant randomised controlled trials and observational studies...
July 25, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28738899/a-rare-manifestation-of-burns-after-lightning-strike-in-rural-ghana-a-case-report
#10
Paschal Awingura Apanga, John Atigiba Azumah, Joseph Bayewala Yiranbon
BACKGROUND: Lightning is a natural phenomenon that mostly affects countries in the tropical and subtropical regions of the globe, including Ghana. Lightning strikes pose a global public health issue. Although strikes to humans are uncommon, it is associated with high morbidity and mortality. CASE PRESENTATION: We present a case of a 10-year-old Ghanaian girl who got second-degree burns after being struck by lightning. She was put on an intravenous broad-spectrum antibiotic (ceftriaxone), Ringer's lactate, and her burns were dressed with sterile gauze impregnated with Vaseline (petroleum jelly) and silver sulfadiazine ointment...
July 25, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28732899/in-situ-reduction-of-silver-nanoparticles-by-chitosan-l-glutamic-acid-hyaluronic-acid-enhancing-antimicrobial-and-wound-healing-activity
#11
Bitao Lu, Fei Lu, Yini Zou, Jiawei Liu, Bao Rong, Zhiquan Li, Fangying Dai, Dayang Wu, Guangqian Lan
Spongy composites with silver nanoparticles (AgNPs) were synthesized by freeze-drying a mixture of silver nitrate (AgNO3) and chitosan-l-glutamic acid (CG) derivative loaded with hyaluronic acid (HA) solution. CG/AgNP spongy composites had an interconnected porous structure and rough surfaces. When AgNPs (5-20nm) were immobilized on these spongy composites, AgNP aggregation was dependent on AgNO3 concentration. The spongy composites exhibited good mechanical properties, swelling, and water retention capacity...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28716748/a-transparent-wound-dressing-based-on-bacterial-cellulose-whisker-and-poly-2-hydroxyethyl-methacrylate
#12
Zeng Di, Zhijun Shi, Muhammad Wajid Ullah, Sixiang Li, Guang Yang
The current study was aimed to develop a transparent wound dressing comprised of bacterial cellulose (BC) and poly (2-hydroxyethyl methacrylate) (PHEMA) hydrogel coated with silver (Ag) nanoparticles. Briefly, different concentrations of BC whiskers (BCWs) were added into the HEMA solution to form PHEMA/BCWs hydrogel with volume ratio of monomer HEMA and BCWs as 7:3 and 1:1. The addition of BCWs into PHEMA matrix improved its equilibrium water content and light transmittance about 20%-40% and 10%, respectively...
July 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28704172/hydroconductive-and-silver-impregnated-foam-dressings-a-comparison
#13
A Alkhalil, A Day, K W Monger, J Zhang, B C Carney, H N Hoffman, L T Moffatt, J W Shupp
OBJECTIVE: As the number of commercially available wound dressings is increasing rapidly, it is important for clinicians to understand the strengths and limitations of each and to recognise relationships between wound type and dressing properties to obtain optimal healing results. Our aim is to test the antimicrobial activity of two dressings. METHOD: A hydroconductive (HC) dressing and a silver-impregnated foam (SIF) dressing were compared for their potential to reduce the levels meticillin-resistant Staphylococcus aureus (MRSA)...
July 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28700086/antiseptics-for-burns
#14
REVIEW
Gill Norman, Janice Christie, Zhenmi Liu, Maggie J Westby, Jayne M Jefferies, Thomas Hudson, Jacky Edwards, Devi Prasad Mohapatra, Ibrahim A Hassan, Jo C Dumville
BACKGROUND: Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to prevent growth of micro-organisms. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. OBJECTIVES: To assess the effects and safety of antiseptics for the treatment of burns in any care setting...
July 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28688669/silver-containing-dressing-for-surgical-site-infection-in-clean-and-clean-contaminated-operations-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
Hui-Zi Li, Lei Zhang, Jia-Xi Chen, Yang Zheng, Xiang-Nan Zhu
BACKGROUND: Silver-containing dressings for the prevention of surgical site infections (SSIs) remained controversial, and accumulating evidence was lacking, so a meta-analysis was conducted to systematically assess the effectiveness and safety of silver-containing dressings for clean and clean-contaminated surgical incisions. METHODS: Pubmed, Embase, and the Cochrane Library were searched from the inception to February 2016 for randomized controlled trials (RCTs), which explored silver-containing dressings for the prevention of SSIs in clean and clean-contaminated operations...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28682725/a-randomized-controlled-trial-on-the-outcome-in-comparing-an-alginate-silver-dressing-with-a-conventional-treatment-of-a-necrotizing-fasciitis-wound
#16
Jarernchon Meekul, Arnon Chotirosniramit, Woraluck Himakalasa, Saritphat Orrapin, Antika Wongthanee, Orapin Pongtam, Kanokwan Kulprachakarn, Kittipan Rerkasem
Necrotizing fasciitis (NF) is a high morbidity and mortality disease and also demands high economic resources. The standard treatment of NF is surgical debridement and proper dressing for wound bed preparation. The efficacy of silver alginate dressing can inhibit the growth of microorganisms and keep the environment clean for wound bed preparation. However an optimal dressing to manage such wounds has yet to emerge. NF patients who were admitted between April 2013 and May 2016 were randomized to have wound dressing using either silver dressing (Ag group) or normal saline solution gauze (NSS group)...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682723/treating-giant-congenital-nevus-with-integra-dermal-regeneration-template-in-a-9-year-old-girl
#17
Zoran Barcot, Dakovic Bacalja Inga, Bozidar Zupancic, Vedran Bacalja
Integra dermal regeneration template has been well established in treating deep extensive burns, but there are very few cases reported of treating large full-thickness skin defects such as giant nevi. Apart from psychological and cosmetic burdens, the giant congenital nevus carries increased risk of malignant alteration. We present the case of a 9-year-old girl with a giant congenital nevus on her left lower leg. A total excision was done and she was successfully treated with Integra (LifeSciences Corp, Plainsboro, NJ)...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682677/randomized-controlled-trial-of-polyhexanide-betaine-gel-versus-silver-sulfadiazine-for-partial-thickness-burn-treatment
#18
Saruta Wattanaploy, Kusuma Chinaroonchai, Nantaporn Namviriyachote, Pornprom Muangman
Silver sulfadiazine is commonly used in the treatment of partial-thickness burns, but it sometimes forms pseudo-eschar and delays wound healing. Polyhexanide/betaine gel, a new wound cleansing and moisturizing product, has some advantages in removing biofilm and promotes wound healing. This study was designed to compare clinical efficacy of polyhexanide/betaine gel with silver sulfadiazine in partial-thickness burn treatment. From September 2013 to May 2015, 46 adult patients with partial-thickness burn ≥10% total body surface area that were admitted to the Burn Unit of Siriraj Hospital within 48 hours after injury were randomly allocated into 2 groups...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28669805/in-vivo-diabetic-wound-healing-potential-of-nanobiocomposites-containing-bamboo-cellulose-nanocrystals-impregnated-with-silver-nanoparticles
#19
Rubbel Singla, Sourabh Soni, Vikram Patial, Pankaj Markand Kulurkar, Avnesh Kumari, Mahesh S, Yogendra S Padwad, Sudesh Kumar Yadav
In diabetes, hyperglycemic state immensely hinders the wound healing. Here, nanobiocomposites (NCs) developed by impregnation of in situ prepared silver nanoparticles in the matrix of bamboo cellulose nanocrystals were investigated for their ability to hasten the progress of healing events in streptozotocin induced diabetic mice model. Wounds treated with topically applied NCs (hydrogels) showed full recovery (98-100%) within 18days post wounding in contrast to the various control groups where incomplete healing (88-92%) was noticed...
June 29, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28619637/preparation-and-characterization-of-silk-sericin-pva-blend-film-with-silver-nanoparticles-for-potential-antimicrobial-application
#20
Huawei He, Rui Cai, Yejing Wang, Gang Tao, Pengchao Guo, Hua Zuo, Liqun Chen, Xinyu Liu, Ping Zhao, Qingyou Xia
Sericin has great potentials in biomedical applications for its good reactive activity, biocompatibility and biodegradability. However, the undesirable mechanical performance limits its application. Here, we developed a green, facile and economic approach to prepare sericin/polyvinyl alcohol (PVA) blend film. Further, silver nanoparticles (AgNPs) were synthesized in situ on the surface of sericin/PVA film via UV-assisted green synthesis method. Mechanical performance, swelling, mass losing and water retention tests showed the blend film had good mechanical performance, hygroscopicity, water retention capacity and low mass losing ratio...
June 12, 2017: International Journal of Biological Macromolecules
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