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https://www.readbyqxmd.com/read/29425164/association-of-alpha-tocopherol-and-ag-sulfadiazine-chitosan-oleate-nanocarriers-in-bioactive-dressings-supporting-platelet-lysate-application-to-skin-wounds
#1
Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Eleonora Dellera, Alessandro Invernizzi, Cinzia Boselli, Antonia Icaro Cornaglia, Claudia Del Fante, Cesare Perotti, Barbara Vigani, Federica Riva, Carla Caramella, Franca Ferrari
Chitosan oleate was previously proposed to encapsulate in nanocarriers some poorly soluble molecules aimed to wound therapy, such as the anti-infective silver sulfadiazine, and the antioxidant α tocopherol. Because nanocarriers need a suitable formulation to be administered to wounds, in the present paper, these previously developed nanocarriers were loaded into freeze dried dressings based on chitosan glutamate. These were proposed as bioactive dressings aimed to support the application to wounds of platelet lysate, a hemoderivative rich in growth factors...
February 9, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29424642/restoring-balance-biofilms-and-wound-dressings
#2
Steven L Percival
Biofilms are responsible for stimulating and maintaining wound inflammation, increasing infection risk and delaying wound closure. Appropriate biofilm management is required to fight against local and systemic infection and to restore balance to the wound environment. The most effective way to remove biofilms involves the use of mechanical techniques, with the wound dressing representing an important component of this strategy. Wound dressing fibres, such as polyacrylate fibres, have been shown to be effective in affecting biofilm architecture by disrupting the biofilm matrix...
February 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29396683/alginate-membranes-loaded-with-hyaluronic-acid-and-silver-nanoparticles-to-foster-tissue-healing-and-to-control-bacterial-contamination-of-non-healing-wounds
#3
Lorena Tarusha, Sergio Paoletti, Andrea Travan, Eleonora Marsich
Chronic non-healing wounds are a clinically important problem in terms of number of patients and costs. Wound dressings such as hydrogels, hydrocolloids, polyurethane films and foams are commonly used to manage these wounds since they tend to maintain a moist environment which is shown to accelerate re-epithelialization. The use of antibacterial compounds is important in the management of wound infections. A novel wound-dressing material based on a blended matrix of the polysaccharides alginate, hyaluronic acid and Chitlac-silver nanoparticles is here proposed and its application for wound healing is examined...
February 2, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29391092/outcomes-of-unroofing-with-limited-excision-and-structured-postoperative-care-for-pilonidal-disease
#4
Farees Ricky Tavangari, Jennifer Amy Lee, David Garza, Talar Tejirian
Despite a wide variety of surgical techniques to treat chronic pilonidal disease, high rates of recurrence are common. The current study analyzes the outcome of unroofing with limited excision combined with structured postoperative wound care for pilonidal disease. We performed a retrospective review of all patients who were treated with this technique over a seven year period. Ninety-four patients aged 11 to 63 (mean age 26) received this treatment for pilonidal disease. Eighty-nine patients were treated for primary pilonidal disease and five were treated for recurrent disease after procedures such as flaps...
October 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29369640/observation-of-tunable-charged-exciton-polaritons-in-hybrid-monolayer-ws2-plasmonic-nanoantenna-system
#5
Jorge Cuadra, Denis G Baranov, Martin Wersäll, Ruggero Verre, Tomasz J Antosiewicz, Timur Shegai
Formation of dressed light-matter states in optical structures, manifested as Rabi splitting of the eigen energies of a coupled system, is one of the key effects in quantum optics. In pursuing this regime with semiconductors, light is usually made to interact with excitons - electrically neutral quasiparticles of semiconductors, meanwhile interactions with charged three-particle states - trions - have received little attention. Here, we report on strong interaction between localized surface plasmons in silver nanoprisms and excitons and trions in monolayer tungsten disulphide (WS2)...
January 25, 2018: Nano Letters
https://www.readbyqxmd.com/read/29363857/the-influence-of-human-acute-wound-fluid-on-the-antibacterial-efficacy-of-different-antiseptic-polyurethane-foam-dressings-an-in-vitro-analysis
#6
Julian-Dario Rembe, Carolin Fromm-Dornieden, Julia Böhm, Ewa K Stuermer
Treating infected acute and/or chronic wounds still represents a major challenge in medical care. Various interactions of antiseptic dressings with wound environments regarding antimicrobial efficacy remain unclear. Therefore, this work aimed to investigate the influence of human acute wound fluid (AWF) on the antimicrobial performance of different antiseptic foam dressings in-vitro against typical bacterial wound pathogens. Eight antiseptic polyurethane foam dressings containing either a silver formulation or Polyhexamethylene-biguanide (PHMB) were assessed regarding their antimicrobial potency against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa using a modified Time-Kill-Assay based on ISO EN 20743...
January 24, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29352894/a-novel-wound-dressing-based-on-a-konjac-glucomannan-silver-nanoparticle-composite-sponge-effectively-kills-bacteria-and-accelerates-wound-healing
#7
Honglei Chen, Guangqian Lan, Luoxiao Ran, Yang Xiao, Kun Yu, Bitao Lu, Fangying Dai, Dayang Wu, Fei Lu
A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical properties. KGM/AgNP composite sponges displayed good antibacterial activity against test microorganisms...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29346149/testing-elevated-protease-activity-prospective-analysis-of-160-wounds
#8
Anike Lockmann, Tillmann Schill, Franziska Hartmann, Lisa-Lena Grönemeyer, Ricarda Holzkamp, Michael P Schön, Kai-Martin Thoms
OBJECTIVE: Given that local elevated protease activity (EPA) has been implicated in impaired wound healing, a prospective single-center study was conducted to assess protease activity in various wound types. METHODS: Protease activity was determined using an easy-to-use test system (Woundchek Protease Status Test Kit; Systagenix, Gatwick, United Kingdom) in 160 wounds in 143 patients. The assay detects the combined activity of inflammatory proteases, mainly matrix metalloproteinases 8 and 9 and human neutrophil elastase...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29334612/tempo-oxidized-bacterial-cellulose-pellicle-with-silver-nanoparticles-for-wound-dressing
#9
Chun-Nan Wu, Shih-Chang Fuh, Shin-Ping Lin, Yen-Yi Lin, Hung-Yueh Chen, Jui-Ming Liu, Kuan-Chen Cheng
Biocompatible bacterial cellulose pellicle (BCP) is a candidate for biomedical material such as wound dressing. However, due to lack of antibacterial activity, to grant BCP with the property is crucial for its biomedical application. In the present study, BCP was modified by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation using TEMPO/NaClO/NaBr system at pH 10 to form TEMPO-oxidized BCP (TOBCP) with anionic C6 carboxylate groups. The TOBCP was subsequently ion-exchanged in AgNO3 solution and silver nanoparticles (AgNP) with diameter of ~16...
January 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29333419/evaluation-of-a-polyurethane-foam-dressing-impregnated-with-3-povidone-iodine-betafoam-in-a-rat-wound-model
#10
Jin Won Lee, Kyo Young Song
Purpose: The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety. Methods: Fifty-four male adult Sprague-Dawley rats (weight, 200-250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group): Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29331783/comparative-study-of-novel-in-situ-decorated-porous-chitosan-selenium-scaffolds-and-porous-chitosan-silver-scaffolds-towards-antimicrobial-wound-dressing-application
#11
Dhee P Biswas, Neil M O'Brien-Simpson, Eric C Reynolds, Andrea J O'Connor, Phong A Tran
Dermal defects caused by trauma or disease are challenging to treat due to difficult-to-treat infections that impair wound healing. Due to the widespread emergence of drug-resistant bacteria and dwindling discoveries of new antibiotics, there is currently an urgent need to introduce novel antimicrobials effective against antibiotic-resistant bacteria without causing damage to host tissues. As selenium (Se) and silver (Ag) are known for their antimicrobial properties, we investigated the separate loading of these materials into porous chitosan/PVA (CS) scaffolds through a simple in situ deposition method to create two distinct wound dressing materials (CS-Se and CS-Ag)...
January 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#12
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29319449/management-and-closure-of-multiple-large-cutaneous-lesions-in-a-juvenile-cat-with-severe-acquired-skin-fragility-syndrome-secondary-to-iatrogenic-hyperadrenocorticism
#13
C Noël McKnight, Linda J Lew, David A Gamble
CASE DESCRIPTION A 13-month-old castrated male cat was evaluated for a large, spontaneously developed cutaneous laceration over the left scapular region. The cat had a history of severe gingivostomatitis, conjunctivitis, giardiasis, and feline herpesvirus infection and had received systemic glucocorticoid treatment for 7 weeks prior to evaluation. CLINICAL FINDINGS Physical examination revealed a 10 × 7-cm full-thickness cutaneous laceration over the left scapular region, extremely thin skin, crusts over the dorsal aspect of the neck and base of the skull, medially curling pinnae, and moderate gingivostomatitis...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29297087/biobrane-dressing-for-paediatric-burns-in-singapore-a-retrospective-review
#14
Cong Fan, Chong Han Pek, Yong Chen Por, Gale Jue Shuang Lim
INTRODUCTION: The ideal burn dressing for children should aim to alleviate pain, decrease length of hospital stay and minimise complications, such as conversion and infection. The current literature is still inconclusive with regard to the gold standard burn dressing for the paediatric population. METHODS: We retrospectively reviewed children with superficial partial thickness burns admitted to our paediatric burn unit from January 2014 to April 2015. A total of 30 patients were included in our study, of which 13 had Biobrane dressing...
January 3, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29290512/evaluation-of-the-penetration-of-nanocrystalline-silver-through-various-wound-dressing-mediums-an-in-vitro-study
#15
Magnus D Potgieter, Parastu Meidany
BACKGROUND: The nanocrystalline silver (NCS) dressing Acticoat is commonly used in clinical practice for the treatment of burns and other open wounds as a topical antimicrobial. The dressing may dry resulting in traumatic dressing changes; hence the variety of contact layer dressings used in conjunction with it. Dressing combinations that do not permit NCS penetration are not cost effective and deprives the wound of the needed anti-microbial. METHODS: Common wound pathogens were subjected to a variety of contact layer dressings underlying the NCS dressings...
December 28, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29280301/a-fluorescent-biofunctional-dna-hydrogel-prepared-by-enzymatic-polymerization
#16
Jinhui Geng, Chi Yao, Xiaohong Kou, Jianpu Tang, Dan Luo, Dayong Yang
DNA has arisen as a promising building material for the construction of hydrogels owing to its unique properties such as designability and biocompatibility. All-DNA hydrogels with only DNA molecules may have limited applications; hence a composite DNA hydrogel with multifunctional moieties is highly desired to cater for specific applications. Herein, a multifunctional DNA hydrogel is created by incorporating DNA with silver nanoclusters (AgNCs), in which AgNCs render the hydrogel simultaneously with fluorescent and antibacterial functions...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29261553/local-modalities-for-preventing-surgical-site-infections-an-evidence-based-review
#17
Julia A Katarincic, Amanda Fantry, J Mason DePasse, Ross Feller
Surgical site infections remain a dreaded complication of orthopaedic surgery, affecting both patient economics and quality of life. It is important to note that infections are multifactorial, involving both surgical and patient factors. To decrease the occurrence of infections, surgeons frequently use local modalities, such as methicillin-resistant Staphylococcus aureus screening; preoperative bathing; intraoperative povidone-iodine lavage; and application of vancomycin powder, silver-impregnated dressings, and incisional negative-pressure wound therapy...
January 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29243368/a-2000-patient-retrospective-assessment-of-a-new-strategy-for-burn-wound-management-in-view-of-infection-prevention-and-treatment
#18
Justyna Glik, Wojciech Łabuś, Diana Kitala, Karolina Mikuś-Zagórska, Christopher D Roberts, Mariusz Nowak, Aleksandra Kasperczyk, Marek Kawecki
Infections in burn patients are still the principal cause of complications in burn injuries. The aim of this study is to assess a new strategy for burn wound management in view of infection prevention and treatment in the experience of the Burn Treatment Center in Siemianowice Śląskie. The applied methodology involved the analysis of patient records describing the hospital's epidemiological situation between 2014 and 2016. The analysis also included the use and cost of antibiotics, silver-containing dressings, and other antiseptics relative to the number of sepsis cases, including those caused by Pseudomonas aeruginosa, as well as the mortality ratio...
December 15, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29232530/pediatric-endoscopic-pilonidal-sinus-treatment-a-revolutionary-technique-to-adopt-in-children-with-pilonidal-sinus-fistulas-our-preliminary-experience
#19
Ciro Esposito, Serena Izzo, Francesco Turrà, Mariapina Cerulo, Giovanni Severino, Alessandro Settimi, Marta Iannazzone, Lorenzo Masieri, Giuseppe Cortese, Maria Escolino
AIM: This study aimed to report our preliminary experience with pediatric endoscopic pilonidal sinus treatment (PEPSiT). PATIENTS AND METHODS: We retrospectively reviewed the reports of 15 patients, 6 girls and 9 boys, with an average age of 16 years (range 13-18) with noninfected pilonidal sinus disease who underwent PEPSiT in our institution over an 18-month period. Four cases were redo-procedures, for recurrence of disease after open excision repair. Surgical outcomes of sinus healing, recurrence of disease, postoperative pain, hospital stay, analgesic requirements, and patient satisfaction levels were evaluated and a comparison analysis with classic open repair was performed...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29222019/a-novel-use-of-cellulose-based-filter-paper-containing-silver-nanoparticles-for-its-potential-application-as-wound-dressing-agent
#20
Adnan Haider, Sajjad Haider, Inn-Kyu Kang, Anuj Kumar, Madhusudana Rao Kummara, Tahseen Kamal, Sung Soo Han
The frequent use of antibiotics against microbial infections may lead the emergence of antibiotic resistant microbial strains. To overcome these microbial strains, we need to fabricate alternative materials which can handle them. It is for this reason, we have fabricated cellulose (CE) based filter paper (FP) composite scaffolds comprising of adsorbed chitosan (CS) and sliver (Ag) nanoparticles (NPs). The AgNPs are incorporated in the CS layer of the composite scaffold. Prior to evaluate the efficacy of the scaffolds against gram positive and gram negative bacterial strains, the scaffolds were characterized for the presence of the Ag NPs with field emission scanning electron microscope (FE-SEM), fourier transform infrared (FTIR) spectroscopy and x-ray diffractometer (XRD)...
December 5, 2017: International Journal of Biological Macromolecules
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