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https://www.readbyqxmd.com/read/28619637/preparation-and-characterization-of-silk-sericin-pva-blend-film-with-silver-nanoparticles-for-potential-antimicrobial-application
#1
Huawei He, Rui Cai, Yejing Wang, Gang Tao, Pengchao Guo, Hua Zuo, Liqun Chen, Xinyu Liu, Ping Zhao, Qingyou Xia
Sericin has great potentials in biomedical applications for its good reactive activity, biocompatibility and biodegradability. However, the undesirable mechanical performance limits its application. Here, we developed a green, facile and economic approach to prepare sericin/polyvinyl alcohol (PVA) blend film. Further, silver nanoparticles (AgNPs) were synthesized in situ on the surface of sericin/PVA film via UV-assisted green synthesis method. Mechanical performance, swelling, mass losing and water retention tests showed the blend film had good mechanical performance, hygroscopicity, water retention capacity and low mass losing ratio...
June 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28613416/topical-antimicrobial-agents-for-treating-foot-ulcers-in-people-with-diabetes
#2
REVIEW
Jo C Dumville, Benjamin A Lipsky, Christopher Hoey, Mario Cruciani, Marta Fiscon, Jun Xia
BACKGROUND: People with diabetes are at high risk for developing foot ulcers, which often become infected. These wounds, especially when infected, cause substantial morbidity. Wound treatments should aim to alleviate symptoms, promote healing, and avoid adverse outcomes, especially lower extremity amputation. Topical antimicrobial therapy has been used on diabetic foot ulcers, either as a treatment for clinically infected wounds, or to prevent infection in clinically uninfected wounds...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28609151/optimal-wound-care-management-in-hidradenitis-suppurativa
#3
Abrahem Kazemi, Kelly Carnaggio, Maureen Clark, Cynthia Shephard, Ginette A Okoye
Hidradenitis suppurativa (HS) presents the problem of a chronic, relapsing, painful, draining wound. There is a myriad of HS wound care management strategies implemented by clinicians and patients that is centered around which dressings to use. Many factors affect which HS wound care dressing is the most appropriate to use such as the type of HS wound, cost, ease of application, patient comfort, absorbency, and odor management among many others. In this work, the authors prepare a set of guidelines for optimal HS wound care dressing use based on a tier system, ideal characteristics of HS dressings, and the type of HS lesion...
June 13, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28600506/antibacterial-cellulose-paper-made-with-silver-coated-gold-nanoparticles
#4
Tsung-Ting Tsai, Tse-Hao Huang, Chih-Jung Chang, Natalie Yi-Ju Ho, Yu-Ting Tseng, Chien-Fu Chen
In this study, we investigated the antibacterial activity of silver-coated gold nanoparticles (Au-Ag NPs) immobilized on cellulose paper. Ag NPs are known to have strong antibacterial properties, while Au NPs are biocompatible and relatively simple to prepare. We made the Au-Ag NPs using a facile process called Ag enhancement, in which Au NPs serve as the nuclei for precipitation of a Ag coating, the thickness of which can be easily controlled by varying the ratio of the reactants. After synthesis, electron microscopy showed that the Au-Ag NPs displayed a core-shell structure, and that they could be successfully immobilized onto a cellulose membrane by heat treatment...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28594320/silver-containing-foam-dressings-with-safetac-a-review-of-the-scientific-and-clinical-data
#5
Phil Davies, Sara McCarty, Kristina Hamberg
Background Topical antimicrobials, such as silver dressings, are progressively being used alongside systemic antibiotics to provide adjunctive, antimicrobial therapy to wounds that are clinically infected or at risk of infection. To help improve wound management, dressings that use Safetac soft silicone technology in combination with a silver-impregnated foam dressing material were developed by Mölnlycke Health Care (Gothenburg, Sweden). The range comprises Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag...
June 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28592934/new-dressing-combination-for-the-treatment-of-partial-thickness-burn-injuries-in-children
#6
G Józsa, E Tóth, Zs Juhász
Burns are among the most common causes of injury in children. Several wound dressings are available to conservatively treat second-degree burns. Seventy-three children were treated with Aquacel Ag foam and Zn-hyaluronon gel to determine their effectiveness on partial thickness burns. We applied silver nitrate solution on 25% of patients for 24 hrs, then checked burn depth. If the burn was superficial second degree, we applied the dressing under study. All dressings were removed 6-7 days later. In the remaining children we used Aquacel Ag foam dressing with Zn-hyaluronon gel at first intervention...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28578293/bio-inspired-crosslinking-and-matrix-drug-interactions-for-advanced-wound-dressings-with-long-term-antimicrobial-activity
#7
Chetna Dhand, Mayandi Venkatesh, Veluchami Amutha Barathi, Sriram Harini, Samiran Bairagi, Eunice Goh Tze Leng, Nandhakumar Muruganandham, Kenny Zhi Wei Low, Mobashar Hussain Urf Turabe Fazil, Xian Jun Loh, Dinesh Kumar Srinivasan, Shou Ping Liu, Roger W Beuerman, Navin Kumar Verma, Seeram Ramakrishna, Rajamani Lakshminarayanan
There is a growing demand for durable advanced wound dressings for the management of persistent infections after deep burn injuries. Herein, we demonstrated the preparation of durable antimicrobial nanofiber mats, by taking advantage of strong interfacial interactions between polyhydroxy antibiotics (with varying number of OH groups) and gelatin and their in-situ crosslinking with polydopamine (pDA) using ammonium carbonate diffusion method. Polydopamine crosslinking did not interfere with the antimicrobial efficacy of the loaded antibiotics...
May 26, 2017: Biomaterials
https://www.readbyqxmd.com/read/28571692/understanding-long-term-silver-release-from-surface-modified-porous-titanium-implants
#8
Anish Shivaram, Susmita Bose, Amit Bandyopadhyay
Prevention of orthopedic device related infection (ODRI) using antibiotics has met with limited amount of success and is still a big concern during post-surgery. As an alternative, use of silver as an antibiotic treatment to prevent surgical infections is being used due to the well-established antimicrobial properties of silver. However, in most cases silver is used in particulate form with wound dressings or with short-term devices such as catheters but not with load-bearing implants. We hypothesize that strongly adherent silver to load-bearing implants can offer longer term solution to infection in vivo...
May 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28565829/effects-of-negative-pressure-wound-therapy-combinedwith-microplasma-on-treating-wounds-of-ulcer-and-the-expression-of-heat-shock-protein-90
#9
Zhihong Li, Qihong Wang, Wenxin Mi, Mei Han, Fei Gao, Guangyan Niu, Yindong Ma
The effects of negative pressure wound therapy (NPWT) combined with microplasma on treating wounds of ulcer, and blood perfusion of wound-healing of interface, angiogenesis and the expressions of heat shock protein 90 (HSP90) were explored. We selected continuously 64 patients with wounds of ulcer. The patients were divided into the conventional treatment group (just medical foam dressing and 1% silver sulfadiazine cream for dressing changes) (n=20 cases), the NPWT group (n=22 cases) and the combination group (NPWT combined with microplasma) (n=22 cases), and compared the effects...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28557869/a-prospective-randomized-controlled-trial-comparing-the-outpatient-treatment-of-pediatric-and-adult-partial-thickness-burns-with-suprathel-or-mepilex-ag
#10
Gabriel Hundeshagen, Vanessa N Collins, Paul Wurzer, William Sherman, Charles D Voigt, Janos Cambiaso-Daniel, Omar Nunez-Lopez, Jason Sheaffer, David N Herndon, Celeste C Finnerty, Ludwik K Branski
Modern treatment of partial thickness burns follow the paradigm of less frequent dressing changes to allow for undisturbed reepithelialization of the burn wound. We compared Mepilex Ag (M), a silver-impregnated foam dressing, and Suprathel (S), a DL-lactid acid polymer, in the outpatient treatment of partial thickness burns in pediatric and adult patients. Patients were enrolled in a randomized controlled prospective clinical trial. We monitored time to reepithelialization, wound pain, discomfort during dressing changes, and treatment cost...
May 23, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28531982/study-of-the-keratin-based-therapeutic-dermal-patches-for-the-delivery-of-bioactive-molecules-for-wound-treatment
#11
Kush Kumar Nayak, Pratima Gupta
In the present study, dressing materials were fabricated in the form of dermal patches. The keratin based biocompatible materials, namely Keratin/Alginate, Keratin/Agar, and Keratin/Gellan were developed as therapeutic dermal patches. The patches were coated with green synthesized silver nanoparticles to prevent the microbial infection and were found to be antimicrobial against pathogens. Papain was used in the patches to acquire the enzymatic cell debridement and its activity was measured by reduction rate of benzoyl-l-arginine ethyl ester...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530199/synthesis-of-ag-nps-impregnated-cellulose-composite-material-its-possible-role-in-wound-healing-and-photocatalysis
#12
Attarad Ali, Ihsan Ul Haq, Javeed Akhtar, Muhammad Sher, Naveed Ahmed, Muhammad Zia
Cellulose is the natural biopolymer normally used as supporting agent with enhanced applicability and properties. In present study, cellulose isolated from citrus waste is used for silver nanoparticles (Ag-NPs) impregnation by a simple and reproducible method. The Ag-NPs fabricated cellulose (Ag-Cel) was characterised by powder X-rays diffraction, Fortier transform infrared spectroscopy and scanning electron microscopy. The thermal stability was studied by thermo-gravimetric analysis. The antibacterial activity performed by disc diffusion assay reveals good zone of inhibition against Staphylococcus aureus and Escherichia coli by Ag-Cel as compared Ag-NPs...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28520604/in-vitro-evaluation-of-betafoam-a-new-polyurethane-foam-dressing
#13
Jae-A Jung, Seung-Kyu Han, Seong-Ho Jeong, Eun-Sang Dhong, Kang-Gyun Park, Woo-Kyung Kim
BACKGROUND: A new polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam; Genewell, Seoul, Korea) was recently developed based on the hypothesis that its physical properties, including improved moisture-retention capacity and antimicrobial activity, are at least as good as those achieved with the current foam dressings that contain silver, but also associated with reduced cost and cytotoxicity to host cells. The purpose of this in vitro study was to evaluate the efficacy of Betafoam by comparing its physical properties, antimicrobial activity, and cytotoxicity with those of 3 silver foam dressings (Allevyn-Ag [Smith & Nephew, Hull, United Kingdom]; Mepilex-Ag [Mölnlycke Health Care, Gothenburg, Sweden]; and PolyMem-Ag [Ferris MFG Corp, Burr Ridge, Illinois]) used worldwide...
June 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28503896/antibacterial-efficacy-of-poly-vinyl-alcohol-composite-nanofibers-embedded-with-silver-anchored-silica-nanoparticles
#14
Abdul Wahab Jatoi, Yun Kee Jo, Hoik Lee, Seong-Geun Oh, Dong Soo Hwang, Zeeshan Khatri, Hyung Joon Cha, Ick Soo Kim
Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. Argyria and argyrosis are well known problems of acute toxicity of silver towards human body. Immobilization of silver is an effective approach to reduce silver release. Herein, we present poly(vinyl alcohol) (PVA) composite nanofibers embedded with silver-anchored silica nanoparticles (SSNs) as a novel antibacterial material...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28503756/biofilms-and-delayed-healing%C3%A2-%C3%A2-an-in-vitro-evaluation-of-silver-and-iodine-containing-dressings-and-their-effect-on-bacterial-and-human-cells
#15
Katie A Bourdillon, Craig P Delury, Breda M Cullen
This study investigated whether there are differences in the ability of wound dressings to modulate certain factors known to affect wound healing. A selection of antimicrobial dressings (AQUACEL(®) Ag Extra(™) , AQUACEL(®) Ag+ Extra(™) , IODOFLEX(™) , ACTICOAT(™) 7 and PROMOGRAN PRISMA(™) matrix) were tested for their effect on both bacterial bioburden and human dermal fibroblasts. Some dressings underwent further evaluation for activity against Pseudomonas aeruginosa biofilms using a colony-drip flow reactor model...
May 14, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28476983/biosynthesis-of-silver-and-gold-nanoparticles-using-trichoderma-atroviride-for-the-biological-control-of-phomopsis-canker-disease-in-tea-plants
#16
Ponnusamy Ponmurugan
The biological way of metallic nanoparticles production using ecofriendly biocontrol agents are largely used to control many plant pathogenic microorganisms in agriculture. Hence, an attempt was made to evaluate the potential of suppressive activity of nanoparticles produced by an indigenous isolate, Trichoderma atroviride against a tea pathogenic fungus namely Phomopsis theae. The presence of biosynthesised nanoparticles was primarily confirmed through ultraviolet-visible spectroscopy analysis and was characterised using X-ray diffraction and scanning electron microscopy-energy dispersive X-ray analysis to delineate the size, shape and nature of particles...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28475440/the-effect-of-negative-pressure-wound-therapy-with-antibacterial-dressings-or-antiseptics-on-an-in-vitro-wound-model
#17
J Matiasek, K J Domig, G Djedovic, R Babeluk, O Assadian
OBJECTIVE: The aim of this study was to investigate the bacterial bioburden in experimental in vitro wounds during the application of conventional negative pressure wound therapy (NPWT), with and without antimicrobial dressings (polyhexanide, silver), against NPWT instillation of octenidine. METHOD: Experimental wounds produced in an in vitro porcine wound model were homogenously contaminated with bacterial suspension and treated with NPWT and different options...
May 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28466896/non-sticky-and-antimicrobial-zwitterionic-nanocomposite-dressings-for-infected-chronic-wounds
#18
Kang-Ting Huang, Yun-Lung Fang, Pai-Shan Hsieh, Chun-Chang Li, Niann-Tzyy Dai, Chun-Jen Huang
Zwitterionic poly(sulfobetaine acrylamide) (pSBAA)-based nanocomposite hydrogels impregnated with germicidal silver nanoparticles (AgNPs) were synthesized and implemented for the treatment of infected chronic wounds. The zwitterionic hydrogels exhibited excellent non-sticky properties and had reinforced mechanical properties by the addition of hectorite nanoclay and poly(ethylene glycol)dimethacrylate as physical and chemical crosslinkers, respectively. In addition, AgNPs were grown within the intercalated clay/polymer structure by in situ free radical reduction, as confirmed by UV-vis spectroscopy and transmission electron microscopy (TEM)...
May 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28461267/patient-specific-3d-scanned-and-3d-printed-antimicrobial-polycaprolactone-wound-dressings
#19
Zaid Muwaffak, Alvaro Goyanes, Vivienne Clark, Abdul W Basit, Stephen T Hilton, Simon Gaisford
The increasing prevalence of wound infections caused by antibiotic resistant bacteria is an urgent challenge facing modern medicine. To address this issue the expedient use of antimicrobial metals such as zinc, copper and silver were incorporated into an FDA-approved polymer (polycaprolactone - PCL) to produce filaments for 3D printing. These metals have broad-spectrum antimicrobial properties, and moreover, copper and zinc can enhance the wound healing process. 3D scanning was used to construct 3D models of a nose and ear to provide the opportunity to customize shape and size of a wound dressing to an individual patient...
April 29, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28441045/effects-of-topical-application-of-silver-sulfadiazine-cream-triple-antimicrobial-ointment-or-hyperosmolar-nanoemulsion-on-wound-healing-bacterial-load-and-exuberant-granulation-tissue-formation-in-bandaged-full-thickness-equine-skin-wounds
#20
Caroline C Gillespie Harmon, Jan F Hawkins, Jianming Li, Sean Connell, Margaret Miller, Megan Saenger, Lynetta J Freeman
OBJECTIVE To determine the effects of 3 topically applied treatments (1% silver sulfadiazine cream [SSC], triple antimicrobial ointment [TAO], and hyperosmolar nanoemulsion [HNE]) on microbial counts, exuberant granulation tissue (EGT) development, and reepithelialization of contaminated wounds at the distal aspect of the limbs of horses. ANIMALS 8 healthy adult horses. PROCEDURES A 2.5 × 2.5-cm, full-thickness, cutaneous wound was created at the dorsal aspect of each metacarpus and metatarsus (1 wound/limb/horse), covered with nonadhesive dressing, and bandaged...
May 2017: American Journal of Veterinary Research
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