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https://www.readbyqxmd.com/read/29774401/high-levels-of-serum-sclerostin-and-dkk1-in-a-case-of-klippel-tr%C3%A3-naunay-syndrome
#1
P Muto, A Lo Gullo, G Mandraffino, S Loddo, M Atteritano
Klippel-Trénaunay syndrome (KTS) is described as a complex syndrome characterized by various combinations of capillary, venous, and lymphatic malformations associated with bone and soft tissue hypertrophy. We report a case of a 67-year-old postmenopausal Caucasian women with KTS that shows elevated levels of sclerostin and Dickkopf-related protein 1 (DKK1). Dual-energy X-ray absorptiometry (DXA) BMD T-scores at lumbar spine and femur were normal. Serum calcium and phosphorus levels were consistently normal, 25-hydroxyvitamin D (25OHD) < 30 ng/mL, and normal parathyroid hormone (PTH)...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29758362/the-anti-epileptic-drugs-valproate-carbamazepine-and-levetiracetam-cause-bone-loss-and-modulate-wnt-inhibitors-in-normal-and-ovariectomised-rats
#2
Bushra Parveen, Ambrish Kumar Tiwari, Moon Jain, Subhashis Pal, Naibedya Chattopadhyay, Manjari Tripathi, Divya Vohora
Secondary osteoporosis is the major concern associated with long term intake of antiepileptic drugs (AEDs). Women are the vulnerable targets owing to post-menopausal bone loss. In the present work, we evaluated the effect of 10 weeks of treatment with AED therapy (carbamazepine, CBZ, 75 mg/kg; sodium valproate, SVP, 300 mg/kg; levetiracetam, LTM, 150 mg/kg) on bone mineral density and microarchitecture at femoral epiphysis, lumbar vertebrae and proximal tibia of normal and ovariectomised Wistar rats...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29721077/cyclin-d1-mediated-microrna-expression-signature-predicts-breast-cancer-outcome
#3
Guangxue Wang, Michael Gormley, Jing Qiao, Qian Zhao, Min Wang, Gabriele Di Sante, Shengqiong Deng, Lin Dong, Tim Pestell, Xiaoming Ju, Mathew C Casimiro, Sankar Addya, Adam Ertel, Ayden Tozeren, Qinchuan Li, Zuoren Yu, Richard G Pestell
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly controls the non-coding genome is poorly understood. Methods: Herein, the miRNA signature maintained by endogenous cyclin D1 in human breast cancer cells was defined. In order to determine the clinical significance of the cyclin D1-mediated miRNA signature, we defined a miRNA expression superset from 459 breast cancer samples...
2018: Theranostics
https://www.readbyqxmd.com/read/29720122/prognostic-value-of-dickkopf-1-and-%C3%A3-catenin-expression-in-advanced-gastric-cancer
#4
Soon Auck Hong, Su Hyun Yoo, Han Hong Lee, Der Sheng Sun, Hye Sung Won, Okran Kim, Yoon Ho Ko
BACKGROUND: Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) is not clear. METHODS: In total, 158 patients with AGC who underwent gastric resection were enrolled in this study. DKK1 and ß-catenin expression was evaluated in whole tumor sections by immunohistochemistry. RESULTS: DKK1 expression was high in 73 (46...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29704238/microrna-3064-3p-regulates-the-differentiation-of-cementoblasts-through-targeting-dkk1
#5
C Wang, H Liao, H Sun, Y Zhang, Z Cao
BACKGROUND AND OBJECTIVE: MicroRNAs (miRNAs) are short, noncoding RNAs that interfere with translation of target mRNAs and thereby play a pivotal role in a variety of biological processes. Cementoblasts are the cells that build up cementum. They share a similar gene expression pattern with osteoblasts. Recent studies have suggested that miRNAs are able to control osteoblast-mediated bone formation. However, the effects of miRNA on cementoblast differentiation still remain unsolved. Herein, we wanted to elucidate the role of miR-3064-3p in cementoblast differentiation...
April 27, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29693006/baicalein-accelerates-tendon-bone-healing-via-activation-of-wnt-%C3%AE-catenin-signaling-pathway-in-rats
#6
Xinggui Tian, Huaji Jiang, Yuhui Chen, Xiang Ao, Chuan Chen, Wentao Zhang, Feilin He, Xiaoqing Liao, Xiaocheng Jiang, Tao Li, Zhongmin Zhang, Xintao Zhang
Background: Tendon-bone healing is a reconstructive procedure which requires a tendon graft healing to a bone tunnel or to the surface of bone after the junction injury between tendon, ligament, and bone. The surgical reattachment of tendon to bone often fails due to regeneration failure of the specialized tendon-bone junction. Materials and Methods: An extra-articular tendon-bone healing rat model was established to discuss the effect of the baicalein 10 mg/(kg·d) in accelerating tendon-bone healing progress...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29688389/modulation-of-gsk-3%C3%AE-%C3%AE-catenin-signaling-contributes-to-learning-and-memory-impairment-in-a-rat-model-of-depression
#7
Jiaojie Hui, Jianping Zhang, Mengjia Pu, Xingliang Zhou, Liang Dong, Xuqiang Mao, Guofeng Shi, Jian Zou, Jingjing Wu, Dongmei Jiang, Guangjun Xi
Background: It is widely accepted that cognitive processes, such as learning and memory, are affected in depression, but the molecular mechanisms underlying the interactions of these 2 disorders are not clearly understood. Recently, glycogen synthase kinase-3 beta (GSK-3β)/β-catenin signaling was shown to play an important role in the regulation of learning and memory. Methods: The present study used a rat model of depression, chronic unpredictable stress, to determine whether hippocampal GSK-3β/β-catenin signaling was involved in learning and memory alterations...
April 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29685994/feeder-free-differentiation-of-cells-exhibiting-characteristics-of-corneal-endothelium-from-human-induced-pluripotent-stem-cells
#8
Michael D Wagoner, Laura R Bohrer, Benjamin T Aldrich, Mark A Greiner, Robert F Mullins, Kristan S Worthington, Budd A Tucker, Luke A Wiley
The purpose of this study was to devise a strategy for the derivation of corneal endothelial cells (CEnCs) from adult fibroblast-derived induced pluripotent stem cells (iPSCs). IPSCs were generated from an adult human with normal ocular history via expression of OCT4 , SOX2 , KLF4 and c-MYC Neural crest cells (NCCs) were differentiated from iPSCs via addition of CHIR99021 and SB4315542. NCCs were driven toward a CEnC fate via addition of B27, PDGF-BB and DKK-2 to CEnC media. Differentiation of NCCs and CEnCs was evaluated via rt-PCR, morphological and immunocytochemical analysis...
April 23, 2018: Biology Open
https://www.readbyqxmd.com/read/29683771/wnt-signaling-related-osteokines-at-rest-and-following-plyometric-exercise-in-prepubertal-and-early-pubertal-boys-and-girls
#9
Panagiota Klentrou, Kirina Angrish, Nafisa Awadia, Nigel Kurgan, Rozalia Kouvelioti, Bareket Falk
PURPOSE: This study examined osteokines related to Wnt signaling at rest and in response to plyometric exercise in 12 boys [10.2 (0.4) y] and 12 girls [10.5 (0.4) y]. METHODS: One resting (preexercise) and 3 postexercise (5 min, 1 h, and 24 h) blood samples were analyzed for sclerostin, dickkopf-related protein 1 (DKK-1), osteoprotegerin (OPG), and receptor activator of nuclear factor kappa-β ligand (RANKL). RESULTS: Girls had higher resting sclerostin than boys [187...
April 23, 2018: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29682205/ferric-citrate-and-ferric-edta-but-not-ferrous-sulfate-drive-amphiregulin-mediated-activation-of-the-map-kinase-erk-in-gut-epithelial-cancer-cells
#10
Nathalie M Scheers, Dora I A Pereira, Nuno Faria, Jonathan J Powell
Ferric chelates may be used as oral iron supplements or phosphate binders but both ferric citrate and ferric EDTA have been shown to promote tumor burden in murine models of colon cancer. Here we studied their effects on cancer cell growth, at typical supplemental iron levels encountered in the gastrointestinal tract (0.01-0.2 mM). Caco-2 and/or Hutu-80 cells were exposed to these forms of chelated iron or to ferrous sulfate and outcomes were assessed using cell proliferation assays, proteome profiler arrays, western blot, and ELISA...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29665496/the-serum-level-of-dickkopf-1-in-patients-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#11
REVIEW
Yubo Ma, Xu Zhang, Mengmeng Wang, Qing Xia, Jiajia Yang, Meng Wu, Renfang Han, Mengya Chen, Xingxing Hu, Yaping Yuan, Rui Liu, Guangming Jiang, Guixia Pan, Yanfeng Zou, Shengqian Xu, Faming Pan
OBJECTIVE: Dickkopf-1 (DKK-1) is an endogenous inhibitor of canonical Wnt pathway that was implicated in the pathogenesis of rheumatoid arthritis (RA), but the serum levels of DKK-1 in RA were inconsistent among studies. Therefore, we conducted a meta-analysis to systematically evaluate the relationship between serum DKK-1 levels and RA. METHODS: PubMed, Web of Science and Cochrane Library were comprehensively retrieved till 1 January 2018 for pertinent studies...
April 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29649633/circulating-wnt-inhibitory-factor-1-levels-are-associated-with-development-of-cardiovascular-disease
#12
Claudia Ress, Mariya Paulweber, Georg Goebel, Karin Willeit, Kerstin Rufinatscha, Anna Strobl, Karin Salzmann, Ludmilla Kedenko, Alexander Tschoner, Gabriele Staudacher, Bernhard Iglseder, Herbert Tilg, Bernhard Paulweber, Susanne Kaser
BACKGROUND AND AIMS: Wnt signaling is involved in atherosclerotic plaque formation directly and indirectly by modulating cardiovascular risk factors. We investigated whether circulating concentrations of Wnt inhibitors are associated with cardiovascular events in subjects with intermediate cardiovascular risk. METHODS: 904 non-diabetic subjects participating in the SAPHIR study were assessed. In the SAPHIR study, middle-aged women without overt atherosclerotic disease at study entry were followed up for 10 years...
March 29, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29594994/-k-lysine-acetyltransferase-2a-affects-the-osteogenic-differentiation-of-periodontal-ligament-stem-cells-through-the-canonical-wnt-pathway
#13
Guo Wucheng, Cheng Jieli, Yang Zhengyi, Zhang Yi, He Enliang, Qian Jun, Song Jingjing, Sun Jin, Yuan Lin
OBJECTIVE: This study aims to investigate the mechanism of K (lysine) acetyltransferase 2A (KAT2A) regulation and control on the osteogenic differentiation of periodontal ligament stem cells (PDLSCs). METHODS: The expression levels of KAT2A in PDLSCs were compared from each generation of the normal (H-PDLSCs) and periodontitis tissues (P-PDLSCs). The influences of KAT2A gene interference on the osteogenic differentiation of PDLSCs were also detected. In addition, the influences of the KAT2A gene interference to the canonical Wnt pathway and ligands were detected...
February 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29572027/a-novel-multiple-biomarker-panel-for-the-early-detection-of-high-grade-serous-ovarian-carcinoma
#14
Chanhee Han, Stefania Bellone, Eric R Siegel, Gary Altwerger, Gulden Menderes, Elena Bonazzoli, Tomomi Egawa-Takata, Francesca Pettinella, Anna Bianchi, Francesco Riccio, Luca Zammataro, Ghanshyam Yadav, Jarrod A Marto, Marie-France Penet, Douglas A Levine, Ronny Drapkin, Abhijit Patel, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Peter E Schwartz, Alessandro D Santin
INTRODUCTION: Since the majority of patients are diagnosed at an advanced stage, ovarian cancer remains the most lethal gynecologic malignancy. There is no single biomarker with the sensitivity and specificity required for effective cancer screening; therefore, we investigated a panel of novel biomarkers for the early detection of high-grade serous ovarian carcinoma. METHODS: Twelve serum biomarkers with high differential gene expression and validated antibodies were selected: IL-1Ra, IL-6, Dkk-1, uPA, E-CAD, ErbB2, SLPI, HE4, CA125, LCN2, MSLN, and OPN...
March 20, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29568962/dickkopf%C3%A2-3-upregulation-mediates-the-cardioprotective-effects-of-curcumin-on-chronic-heart-failure
#15
Quan Cao, Junxia Zhang, Ling Gao, Yijie Zhang, Mingyan Dai, Mingwei Bao
Curcumin, isolated from rhizome of turmeric, has been widely studied as a potential therapeutic drug for cancer. However, protective effects of curcumin on chronic heart failure (CHF) have not been fully studied. In the present study, the effects of curcumin on CHF and the underlying mechanisms were investigated. A total of 40 rabbits were randomized into 4 groups: Control rabbits fed with placebo (Con) or curcumin (Con‑cur), CHF rabbits fed with placebo (CHF) or curcumin (CHF‑cur). CHF was induced by volume and pressure overload...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29568900/glucosamine-promotes-chondrocyte-proliferation-via-the-wnt-%C3%AE-%C3%A2-catenin-signaling-pathway
#16
Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye
The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were determined using reverse transcription‑polymerase chain reaction, western blot analysis and immunohistochemistry. The results indicated that GlcN significantly improved chondrocyte viability, accelerated G1/S transition during progression of the cell cycle and promoted the expression of cell cycle regulatory proteins, including cyclin D1, cyclin‑dependent kinase (CDK)4 and CDK6, thus indicating that GlcN may promote chondrocyte proliferation...
March 22, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29552228/microrna-183-promotes-the-proliferation-and-metastasis-of-renal-cell-carcinoma-through-targeting-dickkopf-related-protein-3
#17
Xiao-Long Zhang, Gang Xu, Yi Zhou, Jia-Jun Yan
Renal cell carcinoma (RCC) is insensitive to conventional chemotherapy and radiotherapy, and its prognosis remains poor. Targeted therapy is a novel technique for the treatment of RCC. The present study aimed to determine the precise effects of microRNA-183 (miR-183) on RCC. Reverse transcription-quantitative polymerase chain reaction analysis was conducted in order to analyze the expression level of miR-183 in RCC cell lines. Cell transfection, viability assays and invasion assays were also performed, followed by western blot analysis and a luciferase reporter assay, in order to examine the effects of miR-183...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29548910/chronic-infusion-of-wnt7a-wnt5a-and-dkk-1-in-the-adult-hippocampus-induces-structural-synaptic-changes-and-modifies-anxiety-and-memory-performance
#18
Abril Ortiz-Matamoros, Clorinda Arias
Wnt signaling plays an important role in the adult brain function and its dysregulation has been implicated in some neurodegenerative pathways. Despite the functional role of the Wnt signaling in adult neural circuits, there is currently no evidence regarding the relationships between exogenously Wnt signaling activation or inhibition and hippocampal structural changes in vivo. Thus, we analyzed the effect of the chronic infusion of Wnt agonists, Wnt7a and Wnt5a, and antagonist, Dkk-1, on different markers of plasticity such as neuronal MAP-2, Tau, synapse number and morphology, and behavioral changes...
March 13, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29544750/dickkopf-1-in-ankylosing-spondylitis-review-and-meta-analysis
#19
REVIEW
Meng Wu, Mengya Chen, Yubo Ma, Jiajia Yang, Renfang Han, Yaping Yuan, Xingxing Hu, Mengmeng Wang, Xu Zhang, Shengqian Xu, Rui Liu, Guangming Jiang, Jianhua Xu, Zongwen Shuai, Yanfeng Zou, Guixia Pan, Faming Pan
BACKGROUND: Current findings regarding serum Dickkopf-1 (DKK-1) concentration in ankylosing spondylitis (AS) have proven inconsistent. This meta-analysis was performed to provide a better understanding of serum DKK-1 and AS. METHODS: Online electronic databases were used to retrieve all relevant articles published before November 2017. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated by the random-effect model. RESULTS: 23 studies, containing 1348 AS patients and 909 healthy controls, were included in this meta-analysis...
March 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29523112/do-hypoxia-and-l-mimosine-modulate-sclerostin-and-dickkopf-1-production-in-human-dental-pulp-derived-cells-insights-from-monolayer-spheroid-and-tooth-slice-cultures
#20
Klara Janjić, Barbara Cvikl, Christoph Kurzmann, Andreas Moritz, Hermann Agis
BACKGROUND: To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkopf-1 (DKK-1) in human dental pulp-derived cells (DPC). METHODS: DPC in monolayer, spheroid and tooth slice cultures were treated with L-MIM or hypoxia. Resazurin-based toxicity and MTT assays were performed to determine cell viability...
March 9, 2018: BMC Oral Health
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