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https://www.readbyqxmd.com/read/29353353/peripheral-th17-treg-imbalance-in-elderly-patients-with-ischemic-stroke
#1
Sanam Dolati, Majid Ahmadi, Mohammad Khalili, Ali Akabar Taheraghdam, Homayoon Siahmansouri, Zohreh Babaloo, Leili Aghebati-Maleki, Farhad Jadidi-Niaragh, Vahid Younesi, Mehdi Yousefi
CD4+CD25+ regulatory T (Treg) cells and Th17 cells play important roles in peripheral immunity. Immune responses are main elements in the pathogenesis of ischemic stroke (IS). The contribution of Th17 cells in IS patients has not been proved, and whether the balance of Treg/Th17 cells is changed in IS patients remains unidentified. In the present study, we studied Th17 and Treg cell frequency, cytokine secretion, expression of transcription factors, and microRNAs related to Th17 and Treg cells differentiation, which is compared between IS patients and control group...
January 20, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29353324/stromalized-microreactor-supports-murine-hematopoietic-progenitor-enrichment
#2
Danika Khong, Matthew Li, Amy Singleton, Ling-Yee Chin, Biju Parekkadan
There is an emerging need to process, expand, and even genetically engineer hematopoietic stem and progenitor cells (HSPCs) prior to administration for blood reconstitution therapy. A closed-system and automated solution for ex vivo HSC processing can improve adoption and standardize processing techniques. Here, we report a recirculating flow bioreactor where HSCs are stabilized and enriched for short-term processing by indirect fibroblast feeder coculture. Mouse 3 T3 fibroblasts were seeded on the extraluminal membrane surface of a hollow fiber micro-bioreactor and were found to support HSPC cell number compared to unsupported BMCs...
January 20, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29353289/the-new-agreement-of-the-international-riga-consensus-conference-on-nasal-airway-function-tests
#3
K Vogt, G Bachmann-Harildstad, A Lintermann, A Nechyporenko, F Peters, K D Wernecke
The report reflects an agreement based on the consensus conference of the International Standardization Committee on the Objective Assessment of the Nasal Airway in Riga, 2nd Nov. 2016. The aim of the conference was to address the existing nasal airway function tests and to take into account physical, mathematical and technical correctness as a base of international standardization as well as the requirements of the Council Directive 93/42/EEC of 14 June 1993 concerning medical devices. Rhinomanometry, acoustic rhinometry, peak nasal inspiratory flow, Odiosoft-Rhino, optical rhinometry, 24-h measurements, computational fluid dynamics, nasometry and the mirrow test were evaluated for important diagnostic criteria, which are the precision of the equipment including calibration and the software applied; validity with sensitivity, specificity, positive and negative predictive values, reliability with intra-individual and inter-individual reproducibility and responsiveness in clinical studies...
January 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29353272/optical-coherence-tomography-angiography-offers-new-insights-into-choriocapillaris-perfusion
#4
Jost L Lauermann, Nicole Eter, Florian Alten
The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy...
January 19, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29353261/impact-of-delivered-tidal-volume-on-the-occurrence-of-intraventricular-haemorrhage-in-preterm-infants-during-positive-pressure-ventilation-in-the-delivery-room
#5
Qaasim Mian, Po-Yin Cheung, Megan O'Reilly, Samantha K Barton, Graeme R Polglase, Georg M Schmölzer
BACKGROUND AND OBJECTIVES: Delivery of inadvertent high tidal volume (VT) during positive pressure ventilation (PPV) in the delivery room is common. High VT delivery during PPV has been associated with haemodynamic brain injury in animal models. We examined if VT delivery during PPV at birth is associated with brain injury in preterm infants <29 weeks' gestation. METHODS: A flow-sensor was placed between the mask and the ventilation device. VT values were compared with recently described reference ranges for VT in spontaneously breathing preterm infants at birth...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353224/coronary-microvascular-dysfunction-may-be-related-to-igf-1-in-acromegalic-patients-and-can-be-restored-by-therapy
#6
Sara Tellatin, Pietro Maffei, Elena Osto, Francesca Dassie, Giulia Famoso, Roberta Montisci, Chiara Martini, Francesco Fallo, Martina Perazzolo Marra, Roberto Mioni, Sabino Iliceto, Roberto Vettor, Francesco Tona
BACKGROUND AND AIMS: Acromegaly increases the risk of cardiovascular mortality. Data on the cardiovascular risk in asymptomatic acromegaly are limited. In particular, data on coronary microvascular abnormalities are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic acromegaly. METHODS: We studied 40 acromegalic patients (23 male, age 52 ± 11 years) without clinical evidence of cardiovascular disease, and 40 control subjects matched for age and sex...
December 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353199/applicability-of-kd-for-modelling-dissolved-137cs-concentrations-in-fukushima-river-water-case-study-of-the-upstream-ota-river
#7
Kazuyuki Sakuma, Hideki Tsuji, Seiji Hayashi, Hironori Funaki, Alex Malins, Kazuya Yoshimura, Hiroshi Kurikami, Akihiro Kitamura, Kazuki Iijima, Masaaki Hosomi
A study is presented on the applicability of the distribution coefficient (Kd) absorption/desorption model to simulate dissolved 137Cs concentrations in Fukushima river water. The upstream Ota River basin was simulated using GEneral-purpose Terrestrial Fluid-flow Simulator (GETFLOWS) for the period 1 January 2014 to 31 December 2015. Good agreement was obtained between the simulations and observations on water and suspended sediment fluxes, and on particulate bound 137Cs concentrations under both base and high flow conditions...
January 17, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29353137/assessment-of-the-cytotoxicity-of-ionic-liquids-on-spodoptera-frugiperda-9-sf-9-cell-lines-via-in-vitro-assays
#8
Shuanggen Wu, Liangbin Zeng, Chaoyun Wang, Yuanru Yang, Wanlai Zhou, Fenfang Li, Zhijian Tan
Cytotoxicity studies are important tools for the assessment of the toxicity of ionic liquids (ILs). In the present study, the cytotoxicity of eleven ILs against Spodoptera frugiperda 9 (Sf-9) cell lines were evaluated via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. The effect on cellular morphology, ultrastructural morphology, and nuclear morphology induced by 1-ethyl-3-methylimidazolium bromide ([C2mim][Br]) was studied via inverted light microscopy observation, acridine orange staining, and transmission electron microscope (TEM) analysis, respectively...
January 17, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29353115/efficient-removal-of-acid-green-25-dye-from-wastewater-using-activated-prunus-dulcis-as-biosorbent-batch-and-column-studies
#9
Suyog N Jain, Parag R Gogate
Biosorbent synthesized from dead leaves of Prunus Dulcis with chemical activation during the synthesis was applied for the removal of Acid Green 25 dye from wastewater. The obtained biosorbent was characterized using Brunauer-Emmett-Teller analysis, Fourier transform-infrared spectroscopy and scanning electron microscopy measurements. It was demonstrated that alkali treatment during the synthesis significantly increased surface area of biosorbent from 67.205 to 426.346 m2/g. The effect of various operating parameters on dye removal was investigated in batch operation and optimum values of parameters were established as pH of 2, 14 g/L as the dose of natural biosorbent and 6 g/L as the dose of alkali treated biosorbent...
January 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29353075/btla-marks-a-less-cytotoxic-t-cell-subset-in-diffuse-large-b-cell-lymphoma-with-high-expression-of-checkpoints
#10
Lina Quan, Xiuwen Lan, Yuanyuan Meng, Xiuchen Guo, Yiwei Guo, Lina Zhao, Xue Chen, Aichun Liu
Immunotherapy has shown encouraging results in lymphoma. Pre-clinical and clinical trials have proven checkpoint blockade, such as PD-1 antibody, as an effective treatment for lymphoma, including diffuse large B-cell lymphoma (DLBCL). Combination of checkpoint blockades has emerged as a new way to treat lymphoma, however, the status of checkpoints expression and their function in DLBCL has not been fully elucidated yet. In this study, we examined the expression of BTLA, PD-1, TIM-3, LIGHT and LAG-3 in tumor micro-environmental T cells of DLBCL using flow cytometry, and compared the cytotoxicity and differentiation status of BTLA+ and BTLA- T-cells...
January 15, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29353013/bottom-up-gamma-maintenance-in-various-disorders
#11
REVIEW
E Garcia-Rill, S Mahaffey, James R Hyde, F J Urbano
Maintained gamma band activity is a key element of higher brain function, participating in perception, executive function, and memory. The pedunculopontine nucleus (PPN), as part of the reticular activating system (RAS), is a major source of the "bottom-up" flow of gamma activity to higher regions. However, interruption of gamma band activity is associated with a number of neurological and psychiatric disorders. This review will focus on the role of the PPN in activating higher regions to induce arousal and descending pathways to modulate posture and locomotion...
January 15, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29353010/modulation-of-immune-responses-by-plasmodium-falciparum-infection-in-asymptomatic-children-living-in-the-endemic-region-of-mbita-western-kenya
#12
Caroline Kijogi, Daisuke Kimura, Lam Quoc Bao, Risa Nakamura, Evans Asena Chadeka, Ngetich Benard Cheruiyot, Felix Bahati, Kazuhide Yahata, Osamu Kaneko, Sammy M Njenga, Yoshio Ichinose, Shinjiro Hamano, Katsuyuki Yui
Individuals living in malaria endemic areas become clinically immune after multiple re-infections over time and remain infected without apparent symptoms. However, it is unclear why a long period is required to gain clinical immunity to malaria, and how such immunity is maintained. Although malaria infection is reported to induce inhibition of immune responses, studies on asymptomatic individuals living in endemic regions of malaria are relatively scarce. We conducted a cross-sectional study of immune responses in asymptomatic school children aged 4-16years living in an area where Plasmodium falciparum and Schistosoma mansoni infections are co-endemic in Kenya...
January 15, 2018: Parasitology International
https://www.readbyqxmd.com/read/29352943/how-does-temperature-govern-mechanisms-of-starch-changes-during-extrusion
#13
Nicolas Logié, Guy Della Valle, Agnès Rolland-Sabaté, Nicolas Descamps, Jérémie Soulestin
Potato and pea starches were processed on a twin-screw extruder under various moisture and thermomechanical conditions, chosen to keep material temperature Te close to starch melting temperature, Tm, whilst avoiding die expansion. Extruded rods were analysed by asymmetrical flow field flow fractionation coupled with light scattering, X-ray diffraction, DSC, and light microscopy with image analysis. Molar mass of extruded materials decreased more for potato than for pea starch, when specific mechanical energy SME increased, likely because of larger amylopectin sensitivity to shear...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352932/the-effect-of-nanocrystalline-cellulose-on-flow-properties-of-fiber-crop-aqueous-suspension
#14
Samira Gharehkhani, Seyed Farid Seyed Shirazi, Hooman Yarmand, Elham Montazer, Salim Newaz Kazi, Rushdan Ibrahim, Mehdi Ashjaei, Nurin Wahidah Binti Mohd Zulkifli, Sadegh Rahmati
Nanocrystalline cellulose (NCC) a nature-based material, has gained significant attentions for its unique properties. The present study aims to investigate the flow behavior of cellulosic suspension containing non-wood pulp fibers and NCC, by means of rheological and pressure drop measurements. The NCC sample was prepared by sulfuric acid hydrolysis from Acacia mangium fibers. The rheological properties of kenaf/NCC suspensions were studied using viscosity and yield stress measurements. The pressure drop properties of the suspension flow were studied with respect to variation in flow velocity (0...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352869/positively-charged-gold-nanoparticles-capped-with-folate-quaternary-chitosan-synthesis-cytotoxicity-and-uptake-by-cancer-cells
#15
Hui-Ju Yen, Yen-An Young, Tsung-Neng Tsai, Kuang-Ming Cheng, Xin-An Chen, Ying-Chuan Chen, Cheng-Cheung Chen, Jenn-Jong Young, Po-da Hong
In this study, we synthesized various quaternary chitosan derivatives and used them to stabilize gold nanoparticles (AuNPs). These chitosan derivatives comprised N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC), folate-HTCC, galactosyl-HTCC, and their fluorescein isothiocyanate-conjugated derivatives. Various positively surface-charged AuNPs were prepared under alkaline conditions using glucose as a reducing agent in the presence of the HTCC derivatives (HTCCs). The effects of the concentration of NaOH, glucose, and HTCCs on the particles size, zeta potential, and stability were studied in detail...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352854/fc-gamma-receptor-binding-profile-of-anti-citrullinated-protein-antibodies-in-immune-complexes-suggests-a-role-for-fc%C3%AE-ri-in-the-pathogenesis-of-synovial-inflammation
#16
Ayla C Kempers, M Reza Nejadnik, Yoann Rombouts, Andreea Ioan-Facsinay, Maikel van Oosterhout, Wim Jiskoot, Tom W J Huizinga, René E M Toes, Hans Ulrich Scherer
OBJECTIVES: Anti-citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). Here, we studied binding of ACPA-IgG immune complexes (IC) to individual Fc gamma receptors (FcγR) to identify potential effector mechanisms by which ACPA could contribute to RA pathogenesis. METHODS: ACPA-IgG1 and control IgG1(IgG1 depleted of ACPA-IgG1) were isolated from plasma and synovial fluid (SF) of RA patients by affinity chromatography using CCP2 peptides...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352779/hydrodynamically-coupled-brownian-dynamics-a-coarse-grain-particle-based-brownian-dynamics-technique-with-hydrodynamic-interactions-for-modeling-self-developing-flow-of-polymer-solutions
#17
V R Ahuja, J van der Gucht, W J Briels
We present a novel coarse-grain particle-based simulation technique for modeling self-developing flow of dilute and semi-dilute polymer solutions. The central idea in this paper is the two-way coupling between a mesoscopic polymer model and a phenomenological fluid model. As our polymer model, we choose Responsive Particle Dynamics (RaPiD), a Brownian dynamics method, which formulates the so-called "conservative" and "transient" pair-potentials through which the polymers interact besides experiencing random forces in accordance with the fluctuation dissipation theorem...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352778/continuum-percolation-of-polydisperse-rods-in-quadrupole-fields-theory-and-simulations
#18
Shari P Finner, Mihail I Kotsev, Mark A Miller, Paul van der Schoot
We investigate percolation in mixtures of nanorods in the presence of external fields that align or disalign the particles with the field axis. Such conditions are found in the formulation and processing of nanocomposites, where the field may be electric, magnetic, or due to elongational flow. Our focus is on the effect of length polydispersity, which-in the absence of a field-is known to produce a percolation threshold that scales with the inverse weight average of the particle length. Using a model of non-interacting spherocylinders in conjunction with connectedness percolation theory, we show that a quadrupolar field always increases the percolation threshold and that the universal scaling with the inverse weight average no longer holds if the field couples to the particle length...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352759/regional-myocardial-function-abnormalities-are-associated-with-macro-and-microcirculation-dysfunction-in-the-metabolic-syndrome-the-resolve-study
#19
Philippe Obert, Guillaume Walther, Frédéric Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix, Agnes Vinet
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eighty-eight MetS individuals and 44 age- and gender-matched healthy controls were enrolled. LV global longitudinal strain (GLS) was measured using Vector Velocity Imaging...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29352749/tips-for-optimizing-organ-preservation-solutions
#20
Aneta Ostróżka-Cieślik, Barbara Dolińska, Florian Ryszka
Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism. Fast cooling of the organ slows down metabolism and activates intracellular enzymes, which minimizes the effects of warm ischemia. Unfortunately, hypothermia also results in inhibition of ATP synthesis, cell swelling and intracellular acidity...
January 20, 2018: Acta Biochimica Polonica
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