Yasmina Curto, Héctor Carceller, Patrycja Klimczak, Marta Perez-Rando, Qing Wang, Katharina Grewe, Riki Kawaguchi, Silvio Rizzoli, Daniel Geschwind, Klaus-Armin Nave, Vicent Teruel-Marti, Manvendra Singh, Hannelore Ehrenreich, Juan Nácher
Severe psychiatric illnesses, for instance schizophrenia, and affective diseases or autism spectrum disorders, have been associated with cognitive impairment and perturbed excitatory-inhibitory balance in the brain. Effects in juvenile mice can elucidate how erythropoietin (EPO) might aid in rectifying hippocampal transcriptional networks and synaptic structures of pyramidal lineages, conceivably explaining mitigation of neuropsychiatric diseases. An imminent conundrum is how EPO restores synapses by involving interneurons...
April 15, 2024: Molecular Psychiatry