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https://www.readbyqxmd.com/read/29241170/rationale-for-aggressive-resection-and-general-surgical-principles-for-intracranial-gliomas
#1
Ian E McCutcheon, Mikhail F Chernov
Given the infiltrative nature of gliomas, controversy has long persisted over the value of their aggressive surgical removal. Nevertheless, in recent decades, the balance of opinion in neurosurgical oncology has shifted from a more nihilistic view that led to many patients' receiving stereotactic biopsy or very limited debulking of lesions for tissue diagnosis only, to more extensive tumor resections which relieve mass effect, lower intracranial pressure, reduce accompanying brain edema, and attenuate dependence on steroids...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29241158/cation-induced-coagulation-of-aquatic-plant-derived-dissolved-organic-matter-investigation-by-eem-parafac-and-ft-ir-spectroscopy
#2
Shasha Liu, Yuanrong Zhu, Leizhen Liu, Zhongqi He, John P Giesy, Yingchen Bai, Fuhong Sun, Fengchang Wu
Complexation and coagulation of plant-derived dissolved organic matter (DOM) by metal cations are important biogeochemical processes of organic matter in aquatic systems. Thus, coagulation and fractionation of DOM derived from aquatic plants by Ca(II), Al(III), and Fe(III) ions were investigated. Metal ion-induced removal of DOM was determined by analyzing dissolved organic carbon in supernatants after addition of these metal cations individually. After additions of metal ions, both dissolved and coagulated organic fractions were characterized by use of fluorescence excitation emission matrix-parallel factor (EEM-PARAFAC) analysis and Fourier transform infrared (FT-IR) spectroscopy...
December 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29241133/oxidation-of-%C3%AE-blockers-by-birnessite-kinetics-mechanism-and-effect-of-metal-ions
#3
Yong Chen, Xiye Lu, Lu Liu, Dong Wan, Huabin Chen, Danna Zhou, Virender K Sharma
Manganese dioxides are ubiquitous in natural waters, soils, and sediments and play an important role in oxidative transformation of organic pollutants. This work presents the kinetics of the oxidation of selected β-blockers, betaxolol, metoprolol, and atenolol by birnessite (δ-MnO2) as a function of concentration of the β-blocker, dosage of δ-MnO2, and solution pH. The values of pseudo-first-order rate constants (kobs) of β-blockers decreased in the order betaxolol > atenolol > metoprolol, which was positively correlated with their acid dissociation constants (Ka)...
December 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29240993/quantifying-bioavailability-of-pyrene-associated-with-dissolved-organic-matter-of-various-molecular-weights-to-daphnia-magna
#4
Hui Lin, Xinghui Xia, Siqi Bi, Xiaoman Jiang, Haotian Wang, Yawei Zhai, Wu Wen
Dissolved organic matter (DOM) is a key environmental factor for the bioavailability of hydrophobic organic compounds (HOCs) in natural waters. However, the bioavailability of DOM-associated HOCs is not clear. In this research, pyrene was selected as a model HOC and its freely dissolved concentration (Cfree) was maintained by passive dosing systems. The immobilization and pyrene content in the tissues excluding gut of Daphnia magna were examined to quantify the bioavailability of DOM-associated pyrene. The results indicated that DOM promoted the bioavailability of pyrene when the Cfree of pyrene was kept constant, and the bioavailability of pyrene associated with DOM of various molecular weights was ordered as middle molecular weight (5-10K Da) DOM > lower molecular weight (<1K Da, 1-3K Da, and 3-5K Da) DOM > higher molecular weight (>10K Da) DOM...
December 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29240977/broadband-homonuclear-decoupled-hsqmbc-methods
#5
István Timári, Katalin E Kövér
Long-range heteronuclear coupling constants convey invaluable information for stereochemical and conformational analysis of molecules from synthetic and natural origin. Here we report a real-time Zangger-Sterk CPMG-HSQMBC method for the precise and direct measurement of multiple-bond heteronuclear couplings. It is demonstrated that the real-time acquisition strategy combined with multiple slice selective excitation can provide substantial improvement in sensitivity (or reduction of experimental time) as compared to other variants of broadband homonuclear decoupled HSQMBC methods published previously...
December 14, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29240819/use-of-thermal-analysis-coupled-with-differential-scanning-calorimetry-quadrupole-mass-spectrometry-and-infrared-spectroscopy-tg-dsc-qms-ftir-to-monitor-chemical-properties-and-thermal-stability-of-fulvic-and-humic-acids
#6
Patrycja Boguta, Zofia Sokołowska, Kamil Skic
Thermogravimetry-coupled with differential scanning calorimetry, quadrupole mass spectrometry, and Fourier-transform infrared spectroscopy (TG-DSC-QMS-FTIR)-was applied to monitor the thermal stability (in an N2 pyrolytic atmosphere) and chemical properties of natural polymers, fulvic (FA) and humic acids (HA), isolated from chemically different soils. Three temperature ranges, R1, 40-220°C; R2, 220-430°C; and R3, 430-650°C, were distinguished from the DSC data, related to the main thermal processes of different structures (including transformations without weight loss)...
2017: PloS One
https://www.readbyqxmd.com/read/29240764/selection-for-long-and-short-sleep-duration-in-drosophila-melanogaster-reveals-the-complex-genetic-network-underlying-natural-variation-in-sleep
#7
Susan T Harbison, Yazmin L Serrano Negron, Nancy F Hansen, Amanda S Lobell
Why do some individuals need more sleep than others? Forward mutagenesis screens in flies using engineered mutations have established a clear genetic component to sleep duration, revealing mutants that convey very long or short sleep. Whether such extreme long or short sleep could exist in natural populations was unknown. We applied artificial selection for high and low night sleep duration to an outbred population of Drosophila melanogaster for 13 generations. At the end of the selection procedure, night sleep duration diverged by 9...
December 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29240584/dermatofibrosarcoma-protuberans-of-distal-extremities-and-acral-sites-a-clinicopathologic-analysis-of-27-cases
#8
Kabeer K Shah, Jonathan B McHugh, Andrew L Folpe, Rajiv M Patel
Dermatofibrosarcoma protuberans (DFSP) of the distal extremities and acral sites are extremely rare and incompletely characterized. Twenty-seven DFSP occurring in these sites were retrieved from our collective archives and reevaluated. Tumors occurred in 16 males and 11 females. Median age at presentation was 42.5 years (range, 7 to 78 y). Lesions involved the foot (18 with 6 in the toes and 2 on the plantar foot), distal ankle (4), hand (4 with 2 in the thumbs), and wrist (1). All cases showed predominantly classic DFSP morphology and were diffusely CD34 positive...
December 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29240314/treatment-of-incarcerated-hernia-in-adults
#9
Jaana Vironen
Of the 14,000 hernias operated annually in Finland, approximately 5 to 6% are treated as emergencies usually due to incarceration. Compared with elective hernia operations, emergency operations carry an increased risk of complications and death, especially in elderly patients and those with comorbidities. The risk of hernia recurrence is higher after an emergency procedure. In an emergency situation, a solution resulting in the best immediate and long-term outcome should be selected for each patient. Sometimes it is best to treat only the acute incarceration, whereas in some cases a hernia repair with good and lasting outcome can be safely performed already during the acute situation...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239690/antibody-drug-conjugates-design-and-development-for-therapy-and-imaging-in-and-beyond-cancer-labex-mabimprove-industrial-workshop-july-27-28-2017-tours-france
#10
Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard, Nicolas Joubert
The annual "Antibody Industrial Symposium", co organized by LabEx MAbImprove, MabDesign and Polepharma, was held in Tours, France on June 27-28, 2017. The focus was on antibody-drug-conjugates (ADCs), new entities which realize the hope of Paul Ehrlich's magic bullet. ADCs result from the bioconjugation of a highly cytotoxic drug to a selective monoclonal antibody, which acts as a vector. Building on knowledge gained during the development of three approved ADCs, brentuximab vedotin (Adcetris®), ado trastuzumab emtansine (Kadcyla®) and inotuzumab ozogamicin (Besponsa®), and the many ADCs in development, this meeting addressed strategies and the latest innovations in the field from fundamental research to manufacturing...
December 14, 2017: MAbs
https://www.readbyqxmd.com/read/29239624/proactive-control-processes-in-event-based-prospective-memory-evidence-from-intraindividual-variability-and-ex-gaussian-analyses
#11
B Hunter Ball, Gene A Brewer
The present study implemented an individual differences approach in conjunction with response time (RT) variability and distribution modeling techniques to better characterize the cognitive control dynamics underlying ongoing task cost (i.e., slowing) and cue detection in event-based prospective memory (PM). Three experiments assessed the relation between proactive control ability, ex-Gaussian parameter estimates (μ and τ), intraindividual variability in responding (coefficient of variation, CoV), and PM cue detection...
December 14, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29239525/isolation-of-sinapic-acid-from-broccoli-using-molecularly-imprinted-polymers
#12
Heba Hosny, Nesrine El Gohary, Engy Saad, Heba Handoussa, Rasha M El Nashar
A molecularly imprinted polymer was synthesized for the purpose of sinapic acid isolation from Egyptian nutraceutical Botrytis italica, L. (broccoli) due to its prominent medicinal and wide pharmacological activities. A computational study was first developed to determine the optimal template to functional monomer molar ratio. Based on the computational results, five polymers were synthesized using a bulk polymerization method with sinapic acid as the template molecule. Evaluation of the synthesized polymers binding performance was carried out using batch rebinding assay, which revealed that the molecularly imprinted polymer of molar ratio (1:4:20), template to functional monomer (4-vinyl pyridine) to crosslinker (ethylene glycol dimethacrylate) was of optimum performance, thus, this polymer was applied for sinapic acid isolation from closely related analogues...
December 14, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29238881/peritoneal-carcinomatosis-of-urachus-origin-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-an-international-registry-of-36-patients
#13
Frederic Mercier, Guillaume Passot, Laurent Villeneuve, Edward A Levine, Yutaka Yonemura, Diane Goéré, Paul H Sugarbaker, Christelle Marolho, David L Bartlett, Olivier Glehen
PURPOSE: Peritoneal carcinomatosis or pseudomyxoma peritonei from urachus is a rare form of presentation, often diagnosed at an advanced state of tumor burden. Because of its rarity, little is known about its natural history, prognosis, or optimal treatment. We searched a large international multicenter database of peritoneal surface disease to identify cases of peritoneal carcinomatosis of urachus that were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) at expert centers...
December 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29238759/neuropsychological-evidence-for-the-temporal-dynamics-of-category-specific-naming
#14
Sven Panis, Katrien Torfs, Celine R Gillebert, Johan Wagemans, Glyn W Humphreys
Multiple accounts have been proposed to explain category-specific recognition impairments. Some suggest that category-specific deficits may be caused by a deficit in recurrent processing between the levels of a hierarchically organized visual object recognition system. Here, we tested predictions of interactive processing theories on the emergence of category-selective naming deficits in neurologically intact observers and in patient GA, a single case showing a category-specific impairment for natural objects after a herpes simplex encephalitis infection...
2017: Visual Cognition
https://www.readbyqxmd.com/read/29238666/preoperative-counseling-and-expectation-management-for-inflatable-penile-prosthesis-implantation
#15
REVIEW
Gopal L Narang, Bradley D Figler, Robert M Coward
The inflatable penile prosthesis (IPP) is the gold standard surgical treatment for medical refractory erectile dysfunction (ED). While the modern IPP has enjoyed high satisfaction rates as a product of its continued innovation, reliability, and performance, patient dissatisfaction can still occur. IPP implantation restores physiologic function with cosmetic and psychological consequences, both of which place inherent emphasis on preoperative counseling and expectation management. This review aims to highlight the complex nature of such counseling and provide practitioners with a roadmap to navigate the landscape...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238566/water-level-affects-availability-of-optimal-feeding-habitats-for-threatened-migratory-waterbirds
#16
Yaara Aharon-Rotman, John McEvoy, Zheng Zhaoju, Hui Yu, Xin Wang, Yali Si, Zhenggang Xu, Zeng Yuan, Wooseog Jeong, Lei Cao, Anthony D Fox
Extensive ephemeral wetlands at Poyang Lake, created by dramatic seasonal changes in water level, constitute the main wintering site for migratory Anatidae in China. Reductions in wetland area during the last 15 years have led to proposals to build a Poyang Dam to retain high winter water levels within the lake. Changing the natural hydrological system will affect waterbirds dependent on water level changes for food availability and accessibility. We tracked two goose species with different feeding behaviors (greater white-fronted geese Anser albifrons [grazing species] and swan geese Anser cygnoides [tuber-feeding species]) during two winters with contrasting water levels (continuous recession in 2015; sustained high water in 2016, similar to those predicted post-Poyang Dam), investigating the effects of water level change on their habitat selection based on vegetation and elevation...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238560/patterns-of-genomic-variation-in-coho-salmon-following-reintroduction-to-the-interior-columbia-river
#17
Nathan R Campbell, Cory Kamphaus, Keely Murdoch, Shawn R Narum
Coho salmon were extirpated in the mid-20th century from the interior reaches of the Columbia River but were reintroduced with relatively abundant source stocks from the lower Columbia River near the Pacific coast. Reintroduction of Coho salmon to the interior Columbia River (Wenatchee River) using lower river stocks placed selective pressures on the new colonizers due to substantial differences with their original habitat such as migration distance and navigation of six additional hydropower dams. We used restriction site-associated DNA sequencing (RAD-seq) to genotype 5,392 SNPs in reintroduced Coho salmon in the Wenatchee River over four generations to test for signals of temporal structure and adaptive variation...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238527/ancestrality-and-evolution-of-trait-syndromes-in-finches-fringillidae
#18
Jean-François Ponge, Dario Zuccon, Marianne Elias, Sandrine Pavoine, Pierre-Yves Henry, Marc Théry, Éric Guilbert
Species traits have been hypothesized by one of us (Ponge, 2013) to evolve in a correlated manner as species colonize stable, undisturbed habitats, shifting from "ancestral" to "derived" strategies. We predicted that generalism, r-selection, sexual monomorphism, and migration/gregariousness are the ancestral states (collectively called strategy A) and evolved correlatively toward specialism, K-selection, sexual dimorphism, and residence/territoriality as habitat stabilized (collectively called B strategy). We analyzed the correlated evolution of four syndromes, summarizing the covariation between 53 traits, respectively, involved in ecological specialization, r-K gradient, sexual selection, and dispersal/social behaviors in 81 species representative of Fringillidae, a bird family with available natural history information and that shows variability for all these traits...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238387/the-tight-interlocked-rhythm-section-production-and-perception-of-synchronisation-in-jazz-trio-performance
#19
Alex Hofmann, Brian C Wesolowski, Werner Goebl
This study investigates the production and perception of timing, synchronisation and dynamics in jazz trio performances. In a production experiment, six trio combinations of one saxophonist, two bassists, and three drummers were recorded while they performed three popular jazz songs. Onset timing and dynamics of each performer were extracted and analysed. Results showed that the tempo was significantly influenced by the timing of the drummers and all performers showed higher temporal precision on the backbeats...
2017: Journal of New Music Research
https://www.readbyqxmd.com/read/29238078/the-genetic-architecture-of-ecological-adaptation-intraspecific-variation-in-host-plant-use-by-the-lepidopteran-crop-pest-chloridea-virescens
#20
Sara J Oppenheim, Fred Gould, Keith R Hopper
Intraspecific variation in ecologically important traits is a cornerstone of Darwin's theory of evolution by natural selection. The evolution and maintenance of this variation depends on genetic architecture, which in turn determines responses to natural selection. Some models suggest that traits with complex architectures are less likely to respond to selection than those with simple architectures, yet rapid divergence has been observed in such traits. The simultaneous evolutionary lability and genetic complexity of host plant use in the Lepidopteran subfamily Heliothinae suggest that architecture may not constrain ecological adaptation in this group...
December 14, 2017: Heredity
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