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https://www.readbyqxmd.com/read/29452350/extra-virgin-olive-oil-contains-a-metabolo-epigenetic-inhibitor-of-cancer-stem-cells
#1
Bruna Corominas-Faja, Elisabet Cuyàs, Jesús Lozano-Sánchez, Sílvia Cufí, Sara Verdura, Salvador Fernández-Arroyo, Isabel Borrás-Linares, Begoña Martin-Castillo, Ángel G Martin, Ruth Lupu, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Vicente Micol, Jorge Joven, Antonio Segura-Carretero, Javier A Menendez
Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and treatment. We herein employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of extra virgin olive oil (EVOO) capable of suppressing the functional traits of CSC in breast cancer (BC). In vitro screening revealed that the secoiridoid decarboxymethyl oleuropein aglycone (DOA) could selectively target sub-populations of epithelial-like, aldehyde dehydrogenase (ALDH)-positive and mesenchymal-like, CD44+CD24-/low CSC...
February 14, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29452261/maternal-betaine-administration-modulates-hepatic-type-1-iodothyronine-deiodinase-dio1-expression-in-chicken-offspring-through-epigenetic-modifications
#2
Zhen Hou, Qinwei Sun, Yun Hu, Shu Yang, Yibo Zong, Ruqian Zhao
As a feed additive, betaine is widely used in livestock production for its ability to promote growth. Our previous studies had reported that maternal betaine supplementation altered hepatic metabolism in offspring. But it remains unknown whether and how maternal betaine modulates metabolism of thyroid hormones in the offspring chickens by epigenetic modification. In this study, one hundred and twenty Rugao yellow-feathered laying hens were randomly divided into two groups, and were fed basal diet with or without 0...
February 13, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29451798/unraveling-the-nature-of-active-sites-in-ethanol-electro-oxidation-by-site-specific-marking-of-a-pt-catalyst-with-isotope-labeled-13co
#3
Manuel J S Farias, William Cheuquepán, Auro A Tanaka, Juan M Feliu
This works deals with the identification of preferential site-specific activation at a model Pt surface during a multi-product reaction. The (110)-type steps of a Pt(332) surface were selectively marked by attaching isotope-labeled 13CO molecules to them, and ethanol oxidation was probed by in situ FTIR in order to precisely determine the specific sites at which CO2, acetic acid, and acetaldehyde were preferentially formed. The (110) steps were active for splitting the C-C bond but, unexpectedly, we provide evidence that the pathway of CO2 formation was preferentially activated at (111) terraces, rather than at (110) steps...
February 16, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29451725/selective-sp3-c-h-aerobic-oxidation-enabled-by-deca-tungstate-photocatalysis-in-flow
#4
Gabriele Laudadio, Sebastian Govaerts, Ying Wang, Davide Ravelli, Hannes Koolman, Maurizio Fagnoni, Stevan Djuric, Timothy Noel
A mild and selective sp3 C-H aerobic oxidation enabled by deca-tungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and the enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C-H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (-)-ambroxide, pregnenolone acetate, (+)-sclareolide and artemisinin exemplifies the utility of this new method...
February 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29451571/sea-spray-aerosol-chemical-composition-elemental-and-molecular-mimics-for-laboratory-studies-of-heterogeneous-and-multiphase-reactions
#5
REVIEW
Timothy H Bertram, Richard E Cochran, Vicki H Grassian, Elizabeth A Stone
Sea spray aerosol particles (SSA), formed through wave breaking at the ocean surface, contribute to natural aerosol particle concentrations in remote regions of Earth's atmosphere, and alter the direct and indirect effects of aerosol particles on Earth's radiation budget. In addition, sea spray aerosol serves as suspended surface area that can catalyze trace gas reactions. It has been shown repeatedly that sea spray aerosol is heavily enriched in organic material compared to the surface ocean. The selective enrichment of organic material complicates the selection of representative molecular mimics of SSA for laboratory or computational studies...
February 16, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29451368/public-health-response-to-an-imported-case-of-canine-melioidosis
#6
C W Ryan, K Bishop, D D Blaney, S J Britton, F Cantone, C Egan, M G Elrod, C W Frye, A M Maxted, G Perkins
Melioidosis in humans presents variably as fulminant sepsis, pneumonia, skin infection and solid organ abscesses. It is caused by Burkholderia pseudomallei, which in the United States is classified as a select agent, with "potential to pose a severe threat to both human and animal health, to plant health or to animal and plant products" (Federal Select Agent Program, http://www.selectagents.gov/, accessed 22 September 2016). Burkholderia pseudomallei is found in soil and surface water in the tropics, especially South-East Asia and northern Australia, where melioidosis is endemic...
February 16, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29451279/nitrogen-doped-nanohoops-as-promising-co-2-capturing-devices
#7
Ángel Vidal Vidal, Carlos Silva López, Olalla Nieto Faza
The impact of climate change in the face of steady or increasing emissions has made the capture and storage of CO 2 a priority issue. Supramolecular chemistry is one of the tools that can be used for this task, due to the possibility of tuning intermolecular interactions for the capture of this gas in a selective and efficient way. In this context, this work presents a novel approach for the capture of CO 2 based on n-cycloparaphenylenes ([n]-CPPs) doped with nitrogen atoms. This is the first time that the potential of these structures for the capture of polluting gases has been evaluated...
February 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29450781/measuring-use-of-evidence-based-psychotherapy-for-posttraumatic-stress-disorder-in-a-large-national-healthcare-system
#8
Shira Maguen, Erin Madden, Olga V Patterson, Scott L DuVall, Lizabeth A Goldstein, Kristine Burkman, Brian Shiner
To derive a method of identifying use of evidence-based psychotherapy (EBP) for post-traumatic stress disorder (PTSD), we used clinical note text from national Veterans Health Administration (VHA) medical records. Using natural language processing, we developed machine-learning algorithms to classify note text on a large scale in an observational study of Iraq and Afghanistan veterans with PTSD and one post-deployment psychotherapy visit by 8/5/15 (N = 255,968). PTSD visits were linked to 8.1 million psychotherapy notes...
February 15, 2018: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/29450705/modeling-competence-development-in-the-presence-of-selection-bias
#9
Sabine Zinn, Timo Gnambs
A major challenge for representative longitudinal studies is panel attrition, because some respondents refuse to continue participating across all measurement waves. Depending on the nature of this selection process, statistical inferences based on the observed sample can be biased. Therefore, statistical analyses need to consider a missing-data mechanism. Because each missing-data model hinges on frequently untestable assumptions, sensitivity analyses are indispensable to gauging the robustness of statistical inferences...
February 15, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29450151/comparison-of-antimicrobial-activities-of-natural-essential-oils-and-synthetic-fragrances-against-selected-environmental-pathogens
#10
Paula L Vieira-Brock, Brent M Vaughan, David L Vollmer
Plant essential oils (EOs) are known to inhibit the growth of bacteria and fungi. Whether these antimicrobial effects are comparable to synthetic household products is less clear. Furthermore, limited research is available on the potential additive effect of blending EOs. In this investigation, a new EO blend containing orange, patchouli, peppermint, and clary sage was compared to its individual single oils and to three household products-air freshener, liquid soap, and body spray-for their ability to inhibit the growth of Staphylococcus aureus, Streptococcus pneumoniae, Pseudonomas aeruginosa, and Aspergillus brasiliensis in the disc-diffusion assay...
December 2017: Biochimie Open
https://www.readbyqxmd.com/read/29449882/mathematical-models-of-lignin-biosynthesis
#11
Mojdeh Faraji, Luis L Fonseca, Luis Escamilla-Treviño, Jaime Barros-Rios, Nancy Engle, Zamin K Yang, Timothy J Tschaplinski, Richard A Dixon, Eberhard O Voit
Background: Lignin is a natural polymer that is interwoven with cellulose and hemicellulose within plant cell walls. Due to this molecular arrangement, lignin is a major contributor to the recalcitrance of plant materials with respect to the extraction of sugars and their fermentation into ethanol, butanol, and other potential bioenergy crops. The lignin biosynthetic pathway is similar, but not identical in different plant species. It is in each case comprised of a moderate number of enzymatic steps, but its responses to manipulations, such as gene knock-downs, are complicated by the fact that several of the key enzymes are involved in several reaction steps...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29449876/authenticity-analyses-of-rhizoma-paridis-using-barcoding-coupled-with-high-resolution-melting-bar-hrm-analysis-to-control-its-quality-for-medicinal-plant-product
#12
Bao-Zhong Duan, Ya-Ping Wang, Hai-Lan Fang, Chao Xiong, Xi-Wen Li, Ping Wang, Shi-Lin Chen
Background: Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. and Paris polyphylla Smith var . chinensis (Franch.) Hara are the two main sources of Chonglou under the monograph of Rhizoma Paridis in Chinese Pharmacopoeia. In the local marketplace, however, this medicine is prone to be accidentally contaminated, deliberately substituted or admixed with other species that are similar to Rhizoma Paridis in shape and color...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29449555/intravenous-injections-of-the-oncolytic-virus-m1-as-a-novel-therapy-for-muscle-invasive-bladder-cancer
#13
Cheng Hu, Ying Liu, Yuan Lin, Jian-Kai Liang, Wen-Wen Zhong, Ke Li, Wen-Tao Huang, De-Juan Wang, Guang-Mei Yan, Wen-Bo Zhu, Jian-Guang Qiu, Xin Gao
Muscle-invasive bladder cancer (MIBC) is associated with low survival and high recurrence rates even in cases in which patients receive systemic treatments, such as surgery and chemotherapy. Here, we found that a naturally existing alphavirus, namely, M1, selectively kills bladder cancer cells but not normal cells, findings supported by our observations of changes in viral replication and MIBC and patient-derived MIBC cell apoptosis. Transcriptome analysis revealed that interferon-stimulated genes (ISGs) are expressed at low levels in sensitive bladder cancer cells and high levels in resistant cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29449486/natural-selection-and-the-predictability-of-evolution-in-timema-stick-insects
#14
Patrik Nosil, Romain Villoutreix, Clarissa F de Carvalho, Timothy E Farkas, Víctor Soria-Carrasco, Jeffrey L Feder, Bernard J Crespi, Zach Gompert
Predicting evolution remains difficult. We studied the evolution of cryptic body coloration and pattern in a stick insect using 25 years of field data, experiments, and genomics. We found that evolution is more difficult to predict when it involves a balance between multiple selective factors and uncertainty in environmental conditions than when it involves feedback loops that cause consistent back-and-forth fluctuations. Specifically, changes in color-morph frequencies are modestly predictable through time ( r 2 = 0...
February 16, 2018: Science
https://www.readbyqxmd.com/read/29449456/place-learning-overrides-innate-behaviors-in-drosophila
#15
Vincent Baggett, Aditi Mishra, Abigail L Kehrer, Abbey O Robinson, Paul Shaw, Troy Zars
Animals in a natural environment confront many sensory cues. Some of these cues bias behavioral decisions independent of experience, and action selection can reveal a stimulus-response (S-R) connection. However, in a changing environment it would be a benefit for an animal to update behavioral action selection based on experience, and learning might modify even strong S-R relationships. How animals use learning to modify S-R relationships is a largely open question. Three sensory stimuli, air, light, and gravity sources were presented to individual Drosophila melanogaster in both naïve and place conditioning situations...
March 2018: Learning & Memory
https://www.readbyqxmd.com/read/29449176/rubber-gloves-biodegradation-by-a-consortium-mixed-culture-and-pure-culture-isolated-from-soil-samples
#16
Chairat Nawong, Kamontam Umsakul, Natthawan Sermwittayawong
An increasing production of natural rubber (NR) products has led to major challenges in waste management. In this study, the degradation of rubber latex gloves in a mineral salt medium (MSM) using a bacterial consortium, a mixed culture of the selected bacteria and a pure culture were studied. The highest 18% weight loss of the rubber gloves were detected after incubated with the mixed culture. The increased viable cell counts over incubation time indicated that cells used rubber gloves as sole carbon source leading to the degradation of the polymer...
February 3, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29448982/stochastic-gating-as-a-novel-mechanism-for-channel-selectivity
#17
Alexander M Berezhkovskii, Sergey M Bezrukov
An ideal channel, responsible for metabolite fluxes in and out of the cells and cellular compartments, is supposed to be selective for a particular set of molecules only. However, such a channel has to be wide enough to accommodate relatively large metabolites, and, therefore, it allows passage of smaller solutes, for example, sodium, potassium, and chloride ions, thus compromising membrane's barrier function. Here we show that stochastic gating is able to provide a mechanism for the selectivity of wide channels in favor of large metabolites...
February 12, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29448943/cloning-and-expression-of-the-sucrose-phosphorylase-gene-in-bacillus-subtilis-and-synthesis-of-kojibiose-using-the-recombinant-enzyme
#18
Miaomiao Wang, Jing Wu, Dan Wu
BACKGROUND: Kojibiose as a prebiotic and inhibitor of α-glucosidase exhibits potential for a wide range of applications in the food and medicine fields; however, large-scale separation and extraction of kojibiose from nature is difficult. Sucrose phosphorylase (SPase) can be used for the production of kojibiose, and currently, SPase is only heterologously expressed in E. coli, making it unsuitable for use in the food industry. However, Bacillus subtilis is generally considered to be a safe organism potentially useful for SPase expression...
February 15, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29448616/flame-retardant-effect-of-nano-fillers-on-polydimethylsiloxane-composites
#19
Pravin Jagdale, Samera Salimpour, Md Hujjatul Islam, Fabio Cuttica, Francisco C Robles Hernandez, Alberto Tagliaferro, Alberto Frache
Polydimethylsiloxane has exceptional fire retardancy characteristics, which make it a popular polymer in flame retardancy applications. Flame retardancy of polydimethylsiloxane with different nano fillers was studied. Polydimethylsiloxane composite fire property varies because of the shape, size, density, and chemical nature of nano fillers. In house made carbon and bismuth oxide nano fillers were used in polydimethylsiloxane composite. Carbon from biochar (carbonised bamboo) and a carbon by-product (carbon soot) were selected...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448591/synthesis-of-hollow-iron-oxide-nanospheres-and-their-application-to-gas-sensors
#20
Kyung Hee Oh, Hyung Ju Park, Shin Wook Kang, Ji Chan Park, Ki Min Nam
Hollow nanomaterials have attracted great interest because of their many applications in catalysis, nanoreactors, drug delivery systems, for lubrication and in gas sensors. Here, carbon sphere templates were prepared from glucose under hydrothermal conditions to facilitate the synthesis of hollow Fe2O3 nanospheres. Thermal decomposition of an iron precursor in benzylalcohol with the carbon spheres resulted in the deposition of Fe3O4 nanoparticles on the carbon sphere templates. The nanoparticles on the carbon surface naturally agglomerate and form a dense oxide shell during the calcination step, which produces typical Fe2O3 hollow structures...
February 1, 2018: Journal of Nanoscience and Nanotechnology
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