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https://www.readbyqxmd.com/read/28636825/a-new-mixed-all-atom-coarse-grained-model-application-to-melittin-aggregation-in-aqueous-solution
#1
Mee Y Shelley, Myvizhi Esai Selvan, Jun Zhao, Volodymyr Babin, Chenyi Liao, Jianing Li, John Clarence Shelley
We introduce a new mixed resolution, all-atom/coarse-grained approach (AACG) for modeling peptides in aqueous solution and apply it to characterizing the aggregation of melittin. All of the atoms in peptidic components are represented while a single site is used for each water molecule. With the full flexibility of the peptide retained, our AACG method achieves speedups by a factor of 3-4 for CPU time reduction and another factor of roughly 7 for diffusion. An Ewald treatment permits the inclusion of long-range electrostatic interactions...
June 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28632688/high-quality-3-dimensional-1h-magnetic-resonance-spectroscopic-imaging-of-the-prostate-without-endorectal-receive-coil-using-a-semi-laser-sequence
#2
Nassim Tayari, Isabell K Steinseifer, Kirsten M Selnæs, Tone F Bathen, Marnix C Maas, Arend Heerschap
OBJECTIVES: Inclusion of 3-dimensional H magnetic resonance spectroscopic imaging (3D-H-MRSI) in routine multiparametric MRI of the prostate requires good quality spectra and easy interpretable metabolite maps of the whole organ obtained without endorectal coil in clinically feasible acquisition times. We evaluated if a semi-LASER pulse sequence with gradient offset independent adiabaticity refocusing pulses (GOIA-sLASER) for volume selection can meet these requirements. MATERIALS AND METHODS: Thirteen patients with suspicion of prostate cancer and 1 patient known to have prostate cancer were examined at 3 T with a multichannel body-receive coil...
June 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28631942/a-systematic-review-of-factors-affecting-driving-and-public-transportation-among-youth-and-young-adults-with-acquired-brain-injury
#3
Sally Lindsay, Andrei Stoica
PURPOSE: Although many people with an acquired brain injury (ABI) encounter difficulties with executive functioning and memory which could negatively affect driving, few people are assessed for fitness to drive after injury. The purpose of this systematic review was to synthesize the literature on factors affecting driving and public transportation among youth and young adults with ABI, post injury. METHOD: Seven databases were systematically searched for articles from 1980 to 2016...
June 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28628873/complexation-thermodynamics-of-%C3%AE-cyclodextrin-with-ionic-surfactants-in-water
#4
Daniel Ondo, Miguel Costas
The interaction of α-cyclodextrin (α-CD) with ten ionic surfactants (S) in water was systematically examined using isothermal titration calorimetry. The S comprised cationic and anionic head groups while the hydrocarbon alkyl chain length varied from eight to fourteen carbon atoms. The heat data were measured at five temperatures ranging from 283.15K to 318.15K and were treated simultaneously allowing the estimation of a thermodynamically consistent temperature dependence of the equilibrium constant, as well as the enthalpy and heat capacity for the sequential formation of the [α-CD·S] and the [α-CD2·S] inclusion complexes...
June 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28596113/evolution-of-delayed-dispersal-and-subsequent-emergence-of-helping-with-implications-for-cooperative-breeding
#5
Geoff Wild, Judith Korb
Cooperative breeding occurs when individuals help raise the offspring of others. It is widely accepted that help displayed by cooperative breeders emerged only after individuals' tendency to delay dispersal had become established. We use this idea as a basis for two inclusive-fitness models: one for the evolution of delayed dispersal, and a second for the subsequent emergence of helpful behavior exhibited by non-breeding individuals. We focus on a territorial species in a saturated environment, and allow territories to be inherited by non-breeding individuals who have delayed dispersal...
June 9, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28594584/attribution-through-the-layperson-s-lens-development-and-preliminary-validation-of-an-inclusive-international-measure-of-beliefs-about-the-causes-of-mental-illness
#6
Brandon A Knettel
Attributions, or beliefs about the causes of mental illness, have traditionally been dichotomized based on their locus, controllability, specificity, and stability. However, scholars have introduced an alternative lay beliefs model identifying attributions related to specific biological, social, and spiritual attributions. This research describes the potential benefits of this alternative model and outlines the validation of a comprehensive, international measure of lay beliefs, the Mental Illness Attribution Questionnaire (MIAQ)...
June 8, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28592604/a-methodologic-framework-for-modeling-and-assessing-biomarkers-of-environmental-enteropathy-as-predictors-of-growth-in-infants-an-example-from-a-peruvian-birth-cohort
#7
Josh M Colston, Pablo Peñataro Yori, Elizabeth Colantuoni, Lawrence H Moulton, Ramya Ambikapathi, Gwenyth Lee, Dixner Rengifo Trigoso, Mery Siguas Salas, Margaret N Kosek
Background: Environmental enteropathy (EE) impairs the gut's absorptive capacity and immune function and causes decelerations in statural growth that manifest gradually over time.Objective: To illustrate an approach for assessing emerging biomarkers of EE, we separately assessed the associations between 3 such markers and subsequent nutritional status.Design: Stool samples were routinely collected between January 2010 and November 2014 from a cohort of 303 Peruvian infants and analyzed for concentrations of the biomarkers α-1-antitrypsin (AAT), myeloperoxidase, and neopterin...
June 7, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28592583/rehabilitation-interventions-to-improve-patient-reported-outcomes-and-physical-fitness-in-survivors-of-muscle-invasive-bladder-cancer-a-systematic-review-protocol
#8
Elke Rammant, Renée Bultijnck, Nora Sundahl, Piet Ost, Nele S Pauwels, Benedicte Deforche, Ronny Pieters, Karel Decaestecker, Valérie Fonteyne
INTRODUCTION: Survivors of muscle invasive bladder cancer (MIBC) experience physical and psychosocial side effects of cancer diagnosis and treatment. These negative side effects have a crucial impact on their health-related quality of life (HRQoL). To date, there is evidence that rehabilitation interventions such as physical activity and psychosocial support have a positive effect on the HRQoL of cancer survivors. Unfortunately, there are no specific guidelines for rehabilitation or survivorship programmes for MIBC survivors...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28592347/management-of-the-thyroid-gland-during-laryngectomy
#9
S X Li, M A Polacco, B J Gosselin, L X Harrington, A J Titus, J A Paydarfar
OBJECTIVES: This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement. METHODS: A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total laryngectomy, type of thyroidectomy, incidence of gland involvement, route of spread, and positive predictors of spread were analysed and reported...
June 8, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28590791/using-an-exercise-program-to-improve-activity-tolerance-in-a-female-with-postural-orthostatic-tachycardia-syndrome-a-case-report
#10
Mike V Richardson, Amy Nordon-Craft, LeeAnne Carrothers
INTRODUCTION: The incidence of postural orthostatic tachycardia syndrome (POTS) is estimated to be at least 500,000 in the United States and is most commonly found in premenopausal females. This syndrome shares clinical features with orthostatic hypotension (OH); however, the inclusion criteria and clinical features for POTS are not well known. The purposes of this case report are to: 1) describe the common clinical features of POTS and highlight the differences to orthostatic hypotension and 2) discuss physical therapy management of patients with POTS using exercise...
June 7, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28586481/dietary-fiber-and-digestive-health-in-children
#11
Renee Korczak, Alison Kamil, Lisa Fleige, Sharon M Donovan, Joanne L Slavin
Digestive health is an expanding area in nutrition research due to the interest in how food components such as fiber affect gastrointestinal tolerance, stool form, defecation frequency, transit time, and gut microbial composition and metabolic activity. In children, however, digestive health studies that intervene with dietary fiber are limited due to legal and ethical concerns. To better understand if fiber improves digestive health in children, a literature review was conducted to answer the following research question: What are the effect(s) of fiber-containing foods and/or supplements on digestive health outcomes in children? A search of the PubMed database identified a total of 12 studies that fit the inclusion criteria established for this review...
April 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28584426/use-of-nutrition-risk-in-critically-ill-nutric-score-to-assess-nutritional-risk-in-mechanically-ventilated-patients-a-prospective-observational-study
#12
M S Kalaiselvan, M K Renuka, A S Arunkumar
CONTEXT: Nutritional risk assessment must be done on all critically ill patients. Malnutrition in intensive care unit (ICU) patients is associated with adverse clinical outcomes. Traditional scoring systems cannot be used for screening in mechanically ventilated (MV) patients because these patients are unable to provide information on their history of food intake and weight loss. The Nutrition Risk in Critically ill (NUTRIC) score is the appropriate nutritional assessment tool in MV patients...
May 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28583760/can-demographic-variables-accurately-predict-component-sizing-in-primary-total-knee-arthroplasty
#13
Robert A Sershon, Paul Maxwell Courtney, Brett D Rosenthal, Scott M Sporer, Brett R Levine
BACKGROUND: As health care reform drives providers to reduce costs and improve efficiencies without compromising patient care, preoperative planning has become imperative. The purpose of this study is to determine whether height, weight, and gender can accurately predict total knee arthroplasty (TKA) sizing. METHODS: A consecutive series of 3491 primary TKAs performed by 2 surgeons was reviewed. Height, weight, gender, implant, preoperative templating sizes, and final implant sizes were collected...
May 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28583620/percutaneous-image-guided-screws-meditated-osteosynthesis-of-impeding-and-pathological-insufficiency-fractures-of-the-femoral-neck-in-non-surgical-cancer-patients
#14
Roberto Luigi Cazzato, Julien Garnon, Georgia Tsoumakidou, Guillaume Koch, Jean Palussière, Afshin Gangi, Xavier Buy
AIM: To present percutaneous image-guided screw-mediated osteosynthesis (PIGSMO) for fixation of impending fractures (ImF) and non-displaced/mildly displaced pathological/insufficient fractures (PF/InF) of the femoral neck in non-surgical cancer patients. MATERIALS AND METHODS: This is a double-centre single-arm observational study. Retrospective review of electronic records identified all oncologic patients who had undergone femoral neck PIGSMO. Inclusion criteria were: non-displaced or mildly displaced PF/InF, and ImF (Mirels' score ≥8); life expectancy ≥1 month; unsuitability for surgical treatment due to sub-optimal clinical fitness, refusal of consent, or unacceptable delay to systemic therapy...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28578726/statistically-derived-subtypes-and-associations-with-cerebrospinal-fluid-and-genetic-biomarkers-in-mild-cognitive-impairment-a-latent-profile-analysis
#15
Joel S Eppig, Emily C Edmonds, Laura Campbell, Mark Sanderson-Cimino, Lisa Delano-Wood, Mark W Bondi
OBJECTIVES: Research demonstrates heterogeneous neuropsychological profiles among individuals with mild cognitive impairment (MCI). However, few studies have included visuoconstructional ability or used latent mixture modeling to statistically identify MCI subtypes. Therefore, we examined whether unique neuropsychological MCI profiles could be ascertained using latent profile analysis (LPA), and subsequently investigated cerebrospinal fluid (CSF) biomarkers, genotype, and longitudinal clinical outcomes between the empirically derived classes...
June 5, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28568112/factors-associated-with-early-extubation-after-superior-cavopulmonary-connection-analysis-from-single-ventricle-reconstruction-trial
#16
D Zakaria, M Rettiganti, J M Gossett, P Gupta
BACKGROUND: To evaluate the landscape of early extubation, and identify factors associated with early extubation (≤ 24 h) after superior cavopulmonary connection (stage 2 operation) among children with single ventricle anatomy. METHODS: Patients undergoing stage 2 operation after Norwood operation from the Pediatric Heart Network Single Ventricle Reconstruction (SVR) trial public-use dataset were included. Elastic net regularized logistic regression models were fitted to evaluate the factors associated with early extubation after stage 2 operation...
June 1, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28561149/-preoperative-evaluation-and-arrangements-the-elderly-patient
#17
Cynthia Olotu-Steffen, Simone Gurlit, Rainer Kiefmann
With a constantly growing portion of elderly within our population and the advances of modern medicine, surgery on aged and very aged patients has become a daily hospital routine. Due to the physical and mental features of ageing these patients face special perioperative risks. They display a higher rate of complications, morbidity and cognitive deficits which might in the end lead to persisting need of care. Even in the healthy elderly, most organ functions are "physiologically" instable or deficient and the homeostasis of health and disease is fragile...
May 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28558805/development-of-a-12-item-short-version-of-the-hiv-stigma-scale
#18
Maria Reinius, Lena Wettergren, Maria Wiklander, Veronica Svedhem, Anna Mia Ekström, Lars E Eriksson
BACKGROUND: Valid and reliable instruments for the measurement of enacted, anticipated and internalised stigma in people living with HIV are crucial for mapping trends in the prevalence of HIV-related stigma and tracking the effectiveness of stigma-reducing interventions. Although longer instruments exist, e.g., the commonly used 40-item HIV Stigma Scale by Berger et al., a shorter instrument would be preferable to facilitate the inclusion of HIV stigma in more and broader surveys. Therefore, the aim of this work was to develop a substantially shorter, but still valid, version of the HIV Stigma Scale...
May 30, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28556686/dominance-genetic-and-maternal-effects-for-genetic-evaluation-of-egg-production-traits-in-dual-purpose-chickens
#19
M Jasouri, P Zamani, S Alijani
1. A study was conducted to study direct dominance genetic and maternal effects on genetic evaluation of production traits in dual purpose chickens. The dataset consisted of records of body weight and egg production of 49749 Mazandaran fowls from 19 consecutive generations. Based on combinations of different random effects, including direct additive and dominance genetic and maternal additive genetic and environmental effects, 8 different models were compared. 2. Inclusion of a maternal genetic effect in the models noticeably improved goodness of fit for all traits...
May 30, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28555707/components-and-indicators-of-frailty-measures-a-literature-review
#20
B Xie, J L Larson, R Gonzalez, S J Pressler, C Lustig, C Arslanian-Engoren
BACKGROUND: Frailty is a debilitating condition in older adults that is associated with increased risks for adverse outcomes. However, the issue of quantifying frailty remains elusive. There is a lack of consistency in the frailty components and the corresponding indicators used to quantify these components. OBJECTIVE: 1) to describe the components of frailty and examine the existing measures of frailty; and 2) to identify current gaps in knowledge of frailty measures...
2017: Journal of Frailty & Aging
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