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https://www.readbyqxmd.com/read/29232006/reconstruction-of-a-large-full-thickness-abdominal-wall-defect-with-flow-through-based-alt-flaps-a-case-report
#1
Dong Yeon Kim, Junho Lee, Jeong Tae Kim, Hye Kyung Chang, Suk-Ho Moon
An extensive 35 × 20 cm sized full-thickness abdominal wall defect was created after resection of aggressive abdominal fibromatosis in a 19-year-old male patient. Immediate reconstruction was not possible due to prolonged operation time and resulting severe bowel edema. A silicone sheet with NPWT was applied over the exposed viscera. After 1 week, silicone sheet was substituted with a composite mesh. Then, abdominal wall reconstruction with bilateral free anterolateral thigh (ALT) flaps (30 × 12 cm and 25 × 12 cm sized) was performed...
December 12, 2017: Microsurgery
https://www.readbyqxmd.com/read/29217444/outcome-and-complications-using-negative-pressure-wound-therapy-in-the-groin-for-perivascular-surgical-site-infections-after-vascular-surgery
#2
Sebastian Andersson, Christina Monsen, Stefan Acosta
AIM OF THE STUDY: The aim of this study was to investigate graft preservation, major bleeding and reinfection rate using negative pressure wound therapy (NPWT) for perivascular surgical site infections (SSI) in the groin after vascular surgery, and factors associated with failure of treatment. MATERIALS AND METHODS: Retrospective data 2004-2015. Failure of wound treatment was defined as a wound not healed within four months, visible graft material or native artery after one month, bleeding from the wound leading to discontinuation of treatment, or death or amputation due to the groin infection...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29211657/open-to-air-is-a-viable-option-for-initial-wound-care-in-necrotizing-soft-tissue-infection-that-allows-early-detection-of-recurrence-without-need-for-painful-dressing-changes-or-return-to-operating-room
#3
Derek Yang, April Davies, Bailey Burge, Phillip Watkins, Sharmila Dissanaike
BACKGROUND: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. We evaluated the feasibility of this approach from a pain control standpoint...
December 6, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29171161/negative-pressure-wound-therapy-in-complex-cranio-maxillofacial-and-cervical-wounds
#4
Giorgio Novelli, Francesco Daleffe, Gisella Birra, Gabriele Canzi, Fabio Mazzoleni, Pietro Boni, Clara Maino, Carlo Giussani, Davide Sozzi, Alberto Bozzetti
The care and the management of the healing of difficult wounds at the level of the skull-facial face many problems related to patient compliance and the need to perform multiple dressings, with long periods of healing and, occasionally, a very long hospitalisation period. The introduction and evolution of negative pressure wound therapy (NPWT) in the treatment of difficult wounds has resulted in better healing, with a drastic reduction in terms of time and biological costs to the patient and cost to the health care system...
November 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29171143/mechanical-effects-of-negative-pressure-wound-therapy-on-abdominal-wounds-effects-of-different-pressures-and-wound-fillers
#5
Christian Torbrand, Erik Anesäter, Ola Borgquist, Malin Malmsjö
The mechanical deformation of the wound edge resulting from negative pressure wound therapy (NPWT) at the standard setting of around -120 mmHg has positive effects in promoting wound healing. However, it may cause pain to the patient during treatment. It is therefore important to study the mechanical effects of the wound edges using lower pressure and different wound fillers. Abdominal wounds were created on eight pigs. The wounds were sealed for NPWT using foam or gauze. Negative pressures between -20 and -160 mmHg were applied, and the decrease in wound diameter and the force with which the edges of the wound were drawn together (wound edge force) were measured...
November 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29166713/-advances-in-the-research-of-molecular-mechanism-of-negative-pressure-wound-therapy-in-improving-wound-healing
#6
Y Liu, D H Hu
Recently, negative pressure wound therapy (NPWT) is a rising technology to improve wound healing. In clinical application, it benefits fast debridement and wound close, limits infection, and promotes wound healing. It is an effective therapy for all kinds of acute or chronic wound. Currently, researches demonstrate that NPWT promotes angiogenesis, granulation tissue growth, and extracellular matrix remodeling through regulating the signaling of anti-inflammatory cytokines, mechanicalreceptor and chemoreceptor, which is related to several growth factors and inflammatory factors...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166258/application-of-a-skin-adhesive-to-maintain-seal-in-negative-pressure-wound-therapy-demonstration-of-a-new-technique
#7
Murad Karadsheh, Josh Nelson, Benjamin Rechner, Richard Wilcox
Optimal wound healing with negative pressure wound therapy (NPWT) relies on a properly sealed vacuum system. Anatomically difficult wounds impair the adhesive dressing, which results in air leaks that disrupt the integrity of the NPWT system and hinder wound healing. OBJECTIVE: The authors demonstrate a new technique using a cyanoacrylate-based tissue adhesive to maintain an airtight, durable seal in NPWT. MATERIALS AND METHODS: A 52-year-old woman with a degloving injury to the right thigh extending into the groin, resulting in massive necrosis, presented to the emergency department...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29153209/-using-negative-pressure-therapy-to-prevent-and-treat-wounds
#8
REVIEW
Marguerite Nicodème, Maxime Chéron, Isabelle Fromantin
The offer of Negative Pressure Wound Therapy (NPWT) has considerably increased these last years. Nowadays, one can choose between different tools such as motorised systems - or not - like pumps; devices which are particularly portables; automated therapies allowing regular instillations; or finally systems adapted to specific indications like "open abdominal wounds". This diversity of devices implies more than ever that prescriptions from the medical doctor be detailed and a good trackability of the nursing follow-up...
November 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29117076/tissue-oxygenation-and-negative-pressure-wound-therapy-when-applied-to-the-feet-of-persons-with-diabetes-mellitus-an-observational-study
#9
Ye-Na Lee, Jong Seok Lee, Seung-Kyu Han, Hye-Kyung Jung
PURPOSE: Our group has reported that negative-pressure wound therapy (NPWT) decreases tissue oxygenation by 84% in the foot of diabetic patients because the pad of the connecting drainage tube and foam sponge of the NPWT system compress the wound bed. The purpose of this study was to determine whether an NPWT modified dressing application reduces tissue oxygenation in the feet of persons with diabetes mellitus. DESIGN: A prospective, clinical, observational study...
November 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29034709/advanced-wound-healing-and-npwt-overcoming-the-challenges
#10
Nicholas Bunce
Nicholas Bunce, Editor of Nursing and Residential Care, discusses some highlights of the recent Hartmann LINK for Wound Healing Congress, which was organised in collaboration with the Journal of Wound Care.
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29031009/fabrication-of-biodegradable-foams-for-deep-tissue-negative-pressure-treatments
#11
Harleigh J Warner, William D Wagner
Devices for negative pressure wound therapy (NPWT) rely on compressible foams operating at the tissue-device interface. Clinically used foams are nonabsorbable and if used on deep wounds or left in place for an extended period of time, excessive cell ingrowth and formation of granulation tissue into the foam may require a surgical procedure to remove the foam. Foams with fast degradation and with low immunogenicity and fibrotic response are required. Foams composed of combinations of poly(lactide-co-glycolide) (PLGA), poly(lactide-co-caprolactone) (PLCL), and polycaprolactone (PCL) were created by combined salt leaching and solvent displacement protocols...
October 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28985633/role-of-negative-pressure-therapy-as-damage-control-in-soft-tissue-reconstruction-for-open-tibial-fractures
#12
Mario Cherubino, Luigi Valdatta, Pierluigi Tos, Salvatore D'Arpa, Luigi Troisi, Pellegatta Igor, Federica Corradi, Umraz Khan
The concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed...
October 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28976835/use-of-cryopreserved-umbilical-cord-with-negative-pressure-wound-therapy-for-complex-diabetic-ulcers-with-osteomyelitis
#13
A Raphael, J Gonzales
OBJECTIVE: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality. METHODS: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis...
October 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28976825/negative-pressure-wound-therapy-versus-gauze-dressings-for-the-treatment-of-contaminated-traumatic-wounds
#14
D Kaushik, Joshi N, R Kumar, Gaba S, R Sapra, K Kumar
OBJECTIVE: This compares hospital suction negative pressure wound therapy (NPWT) with conventional gauze dressings in traumatic soft-tissue injury at a tertiary care centre. METHODS: A prospective control study was conducted between September 2012 and November 2014. Patients with one or more traumatic soft-tissue injuries with contaminated wounds were allocated to either a test group (received NPWT) or control group (received conventional gauze). Wounds were assessed by two orthopaedic surgeons...
October 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28944996/negative-pressure-wound-therapy-promotes-muscle-derived-stem-cell-osteogenic-differentiation-through-mapk-pathway
#15
Hong Liu, Xun Zheng, Liang Chen, Chao Jian, Xiang Hu, Yong Zhao, Zonghuan Li, Aixi Yu
Negative pressure wound therapy (NPWT) has been revealed to be effective in the treatment of open fractures, although the underlying mechanism is not clear. This article aimed to investigate the effects of NPWT on muscle-derived stem cell (MDSC) osteoblastic differentiation and the related potential mechanism. The cell proliferation rate was substantially increased in NPWT-treated MDSCs in comparison with a static group for 3 days. There was no observable effect on the apoptosis of MDSC treated with NPWT compared with the control group for 3 days...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28901392/negative-pressure-wound-therapy-regulating-blood-flow-perfusion-and-microvessel-maturation-through-microvascular-pericytes
#16
Zhanjun Ma, Zonghuan Li, Kangquan Shou, Chao Jian, Pengcheng Li, Yahui Niu, Baiwen Qi, Aixi Yu
Negative pressure wound therapy (NPWT) has been demonstrated to accelerate wound healing by promoting angiogenesis. However, whether blood flow perfusion is regulated by microvessel maturation and pericytes following NPWT remains unclear, as well as the exact association between pericytes and collagen type IV. The aim of this study was to investigate the relevant association between blood flow perfusion and microvessel maturation and pericytes following NPWT, and to further explore the underlying molecular mechanisms...
November 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28894985/virulence-analysis-of-staphylococcus-aureus-in-a-rabbit-model-of-infected-full-thickness-wound-under-negative-pressure-wound-therapy
#17
Daohong Liu, Zhirui Li, Guoqi Wang, Tongtong Li, Lihai Zhang, Peifu Tang
The aim of this study was to evaluate the virulence of Staphylococcus aureus in a controlled animal study using the standard sterile gauze and negative pressure wound therapy (NPWT), including activation of agr, gene expression and production of virulence foctors and depth of bacterial invasion. The tissue specimens were harvested on days 0 (6 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds. Laser scanning confocal microscopy was performed to obtain bioluminescent images which were used to measure the depth of bacterial invasion...
September 11, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28885895/meta-analysis-of-comparative-trials-evaluating-a-prophylactic-single-use-negative-pressure-wound-therapy-system-for-the-prevention-of-surgical-site-complications
#18
REVIEW
Vicki Strugala, Robin Martin
BACKGROUND: We report the first meta-analysis on the impact of prophylactic use of a specific design of negative pressure wound therapy (NPWT) device on surgical site complications. METHODS: Articles were identified in which the specific single-use NPWT device (PICO(⋄), Smith & Nephew) was compared with standard care for surgical site infection (SSI), dehiscence, or length of stay (LOS). Risk ratio (RR) ±95% confidence interval (CI) (SSI; dehiscence) or mean difference in LOS ±95% CI was calculated using RevMan v5...
October 2017: Surgical Infections
https://www.readbyqxmd.com/read/28882357/evaluation-of-negative-pressure-wound-therapy-to-closed-laparotomy-incisions-in-acute-care-surgery
#19
Elleson Schurtz, Jerome Differding, Eric Jacobson, Christopher Maki, Mentor Ahmeti
BACKGROUND: Surgical site complications in the form of wound infections are a major burden to the healthcare system. Negative pressure wound therapy (NPWT) as delivered by a surgical incision management system (SIMS) is a novel approach to improve wound healing when applied to closed incisions. However, data is limited in its application to laparotomy incisions in the acute care surgery setting. METHODS: A retrospective case-control study was performed to evaluate the outcomes of SIMS with regard to surgical site infections in a series of 48 consecutive patients in which SIMS was applied to closed laparotomy incisions in the acute care surgery setting...
August 23, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28873059/traction-assisted-internal-negative-pressure-wound-therapy-with-bridging-retention-sutures-to-facilitate-staged-closure-of-high-risk-wounds-under-tension
#20
Michael V DeFazio, James M Economides, Ersilia L Anghel, Ryan K Mathis, John R Barbour, Christopher E Attinger
BACKGROUND/OBJECTIVE: Loss of domain often complicates attempts at delayed wound closure in regions of high tension. Wound temporization with traction-assisted internal negative pressure wound therapy (NPWT), using bridging retention sutures, can minimize the effects of edema and elastic recoil that contribute to progressive tissue retraction over time. The investigators evaluated the safety and efficacy of this technique for complex wound closure. MATERIALS AND METHODS: Between May 2015 and November 2015, 18 consecutive patients underwent staged reconstruction of complex and/or contaminated soft tissue defects utilizing either conventional NPWT or modified NPWT with instillation and continuous dermatotraction via bridging retention sutures...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
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