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https://www.readbyqxmd.com/read/29139618/beyond-sarcopenia-characterization-and-integration-of-skeletal-muscle-quantity-and-radiodensity-in-a-curable-breast-cancer-population
#1
Marc S Weinberg, Shlomit S Shachar, Hyman B Muss, Allison M Deal, Karteek Popuri, Hyeon Yu, Kirsten A Nyrop, Shani M Alston, Grant R Williams
Skeletal muscle loss, commonly known as sarcopenia, is highly prevalent and prognostic of adverse outcomes in oncology. However, there is limited information on adults with early breast cancer and examination of other skeletal muscle indices, despite the potential prognostic importance. This study characterizes and examines age-related changes in body composition of adults with early breast cancer and describes the creation of a novel integrated muscle measure. Female patients diagnosed with stage I-III breast cancer with abdominal computerized tomography (CT) scans within 12 weeks from diagnosis were identified from local tumor registry (N = 241)...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/28832677/fish-oil-mitigates-myosteatosis-and-improves-chemotherapy-efficacy-in-a-preclinical-model-of-colon-cancer
#2
Alaa A Almasud, Kaitlin H Giles, John J Miklavcic, Karen J B Martins, Vickie E Baracos, Charles T Putman, Leluo L Guan, Vera C Mazurak
BACKGROUND: This study aimed to assess whether feeding a diet containing fish oil was efficacious in reducing tumor- and subsequent chemotherapy-associated myosteatosis, and improving tumor response to treatment. METHODS: Female Fischer 344 rats were fed either a control diet for the entire study (control), or switched to a diet containing fish oil (2.0 g /100 g of diet) one week prior to tumor implantation (long term fish oil) or at the start of chemotherapy (adjuvant fish oil)...
2017: PloS One
https://www.readbyqxmd.com/read/28760426/body-composition-measurement-using-computed-tomography-does-the-phase-of-the-scan-matter
#3
Katie E Rollins, Hannah Javanmard-Emamghissi, Amir Awwad, Ian A Macdonald, Kenneth C H Fearon, Dileep N Lobo
OBJECTIVES: The aim of this study was to determine, from the methodologic standpoint, the effect of the presence or absence of intravenous contrast on body composition variables obtained by analysis of computed tomography (CT) images. METHODS: Triphasic abdominal (noncontrast, arterial phase, and portovenous phase contrast) CT scans from 111 patients were analyzed by two independent assessors at the third lumbar vertebral level using SliceOmatic software (version 5...
September 2017: Nutrition
https://www.readbyqxmd.com/read/28566220/the-relationship-between-tumour-stage-systemic-inflammation-body-composition-and-survival-in-patients-with-colorectal-cancer
#4
Stephen T McSorley, Douglas H Black, Paul G Horgan, Donald C McMillan
BACKGROUND: Disease progression in cancer is often associated with loss of weight and lean tissue and the development of a systemic inflammatory response (SIR) and these have prognostic value. The present study investigated the relationship between these factors in patients with operable colorectal cancer. METHODS: The study included 322 patients with primary operable colorectal cancer. In addition to BMI, pre-operative CT scans were used to define the presence of visceral obesity, sarcopenia and myosteatosis...
May 19, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27903267/skeletal-muscle-quality-as-assessed-by-ct-derived-skeletal-muscle-density-is-associated-with-6-month-mortality-in-mechanically-ventilated-critically-ill-patients
#5
Wilhelmus G P M Looijaard, Ingeborg M Dekker, Sandra N Stapel, Armand R J Girbes, Jos W R Twisk, Heleen M Oudemans-van Straaten, Peter J M Weijs
BACKGROUND: Muscle quantity at intensive care unit (ICU) admission has been independently associated with mortality. In addition to quantity, muscle quality may be important for survival. Muscle quality is influenced by fatty infiltration or myosteatosis, which can be assessed on computed tomography (CT) scans by analysing skeletal muscle density (SMD) and the amount of intermuscular adipose tissue (IMAT). We investigated whether CT-derived low skeletal muscle quality at ICU admission is independently associated with 6-month mortality and other clinical outcomes...
December 1, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27493866/sarcopenic-obesity-and-myosteatosis-are-associated-with-higher-mortality-in-patients-with-cirrhosis
#6
Aldo J Montano-Loza, Paul Angulo, Judith Meza-Junco, Carla M M Prado, Michael B Sawyer, Crystal Beaumont, Nina Esfandiari, Mang Ma, Vickie E Baracos
BACKGROUND AND AIMS: Obesity is frequently associated with cirrhosis, and cirrhotic patients may develop simultaneous loss of skeletal muscle and gain of adipose tissue, culminating in the condition of sarcopenic obesity. Additionally, muscle depletion is characterized by both a reduction in muscle size and increased proportion of muscular fat, termed myosteatosis. In this study, we aimed to establish the frequency and clinical significance of sarcopenia, sarcopenic obesity and myosteatosis in cirrhotic patients...
May 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27379021/fatty-infiltration-of-skeletal-muscle-mechanisms-and-comparisons-with-bone-marrow-adiposity
#7
REVIEW
Mark W Hamrick, Meghan E McGee-Lawrence, Danielle M Frechette
Skeletal muscle and bone share common embryological origins from mesodermal cell populations and also display common growth trajectories early in life. Moreover, muscle and bone are both mechanoresponsive tissues, and the mass and strength of both tissues decline with age. The decline in muscle and bone strength that occurs with aging is accompanied in both cases by an accumulation of adipose tissue. In bone, adipocyte (AC) accumulation occurs in the marrow cavities of long bones and is known to increase with estrogen deficiency, mechanical unloading, and exposure to glucocorticoids...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27156809/laparoscopic-colorectal-cancer-surgery-combined-with-enhanced-recovery-after-surgery-protocol-eras-reduces-the-negative-impact-of-sarcopenia-on-short-term-outcomes
#8
COMMENT
M Pędziwiatr, M Pisarska, P Major, A Grochowska, M Matłok, K Przęczek, T Stefura, A Budzyński, S Kłęk
INTRODUCTION: Progressive skeletal muscle loss (sarcopenia) is a negative prognostic factor in patients treated for colorectal cancer. Nevertheless, the clinical impact of those changes in body composition has been analyzed only in patients undergoing open resections. The aim of the study was to assess whether laparoscopy may eliminate the deleterious prognostic impact of sarcopenia and whether the combination with enhanced recovery after surgery (ERAS) protocol may improve postoperative recovery also in sarcopenic patients...
June 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27076522/greater-skeletal-muscle-fat-infiltration-is-associated-with-higher-all-cause-mortality-among-men-of-african-ancestry
#9
Qian Zhao, Joseph M Zmuda, Allison L Kuipers, Pallavi Jonnalagadda, Clareann H Bunker, Alan L Patrick, Ada O Youk, Iva Miljkovic
BACKGROUND: fat infiltration within and around skeletal muscle (i.e. myosteatosis) increases with ageing, is greater in African versus European ancestry men and is associated with poor health. Myosteatosis studies of mortality are lacking, particularly among African ancestry populations. METHODS: in the Tobago Health study, a prospective longitudinal study, we evaluated the association of all-cause mortality with quantitative computed tomography (QCT) measured lower leg myosteatosis (intermuscular fat (IM fat) and muscle density) in 1,652 African ancestry men using Cox proportional hazards models...
July 2016: Age and Ageing
https://www.readbyqxmd.com/read/27023701/role-of-nutrition-and-muscle-in-cirrhosis
#10
REVIEW
Ragesh B Thandassery, Aldo J Montano-Loza
Most widely recognized complications in cirrhotic patients include ascites, hepatic encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma; however, malnutrition and muscle wasting (sarcopenia) constitute common complications which negatively impact survival, quality of life, and response to stressors, such as infection and surgery in patients with cirrhosis. Despite the important role that malnutrition and sarcopenia play in the prognosis of patients with cirrhosis, they are frequently overlooked, in part because nutritional assessment can be a difficult task in patients with cirrhosis due to fluid retention and/or overweight...
June 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/26994716/influence-of-body-composition-profile-on-outcomes-following-colorectal-cancer-surgery
#11
G Malietzis, A C Currie, T Athanasiou, N Johns, N Anyamene, R Glynne-Jones, R H Kennedy, K C H Fearon, J T Jenkins
BACKGROUND: Muscle depletion is characterized by reduced muscle mass (myopenia), and increased infiltration by intermuscular and intramuscular fat (myosteatosis). This study examined the role of particular body composition profiles as prognostic markers for patients with colorectal cancer undergoing curative resection. METHODS: Patients with colorectal cancer undergoing elective surgical resection between 2006 and 2011 were included. Lumbar skeletal muscle index (LSMI), visceral adipose tissue (VAT) surface area and mean muscle attenuation (MA) were calculated by analysis of CT images...
April 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26643983/muscle-quality-and-myosteatosis-novel-associations-with-mortality-risk-the-age-gene-environment-susceptibility-ages-reykjavik-study
#12
Ilse Reinders, Rachel A Murphy, Ingeborg A Brouwer, Marjolein Visser, Lenore Launer, Kristin Siggeirsdottir, Gudny Eiriksdottir, Vilmundur Gudnason, Palmi V Jonsson, Thomas F Lang, Tamara B Harris
Muscle composition may affect mortality risk, but prior studies have been limited to specific samples or less precise determination of muscle composition. We evaluated associations of thigh muscle composition, determined using computed tomography imaging, and knee extension strength with mortality risk among 4,824 participants aged 76.4 (standard deviation (SD), 5.5) years from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (2002-2006). Cox proportional hazards models were used to estimate hazard ratios...
January 1, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/26179425/the-prognostic-significance-and-relationship-with-body-composition-of-ccr7-positive-cells-in-colorectal-cancer
#13
George Malietzis, Gui Han Lee, David Bernardo, Alexandra I F Blakemore, Stella C Knight, Morgan Moorghen, Hafid O Al-Hassi, John T Jenkins
BACKGROUND AND OBJECTIVES: The host local immune response (LIR) to cancer is a determinant of cancer outcome. Regulation of this local response is largely achieved through chemokine synthesis from the tumor microenvironment such as C-Chemokine-Receptor-7 (CCR7). We examined the LIR measured as CCR7 expression, in colorectal cancers (CRC) and explored relationships with body composition (BC) and survival. METHODS: A study of paraffin-embedded tissue specimens was carried out in 116 patients with non-metastatic CRC...
July 2015: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25963482/effect-of-intramuscular-adipose-tissue-content-on-prognosis-in-patients-undergoing-hepatocellular-carcinoma-resection
#14
Masaki Kaibori, Morihiko Ishizaki, Hiroya Iida, Kosuke Matsui, Tatsuma Sakaguchi, Kentaro Inoue, Toshihiko Mizuta, Yasushi Ide, Junji Iwasaka, Yutaka Kimura, Fumikazu Hayashi, Daiki Habu, Masanori Kon
BACKGROUND: It has recently been reported that myosteatosis, the infiltration of fat in skeletal muscle, is associated with insulin resistance and type 2 diabetes mellitus. The present study investigated the effect of skeletal muscle fat accumulation on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC) and aimed to identify prognostic factors. METHODS: The records of 141 HCC patients who underwent hepatectomy were retrospectively reviewed...
July 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/25838547/greater-skeletal-muscle-fat-infiltration-is-associated-with-higher-all-cause-and-cardiovascular-mortality-in-older-men
#15
MULTICENTER STUDY
Iva Miljkovic, Allison L Kuipers, Jane A Cauley, Tanushree Prasad, Christine G Lee, Kristine E Ensrud, Peggy M Cawthon, Andrew R Hoffman, Thuy-Tien Dam, Christopher L Gordon, Joseph M Zmuda
BACKGROUND: Skeletal muscle fat infiltration (myosteatosis) increases with aging, and has been associated with poor metabolic and musculoskeletal health, independent of overall adiposity. Studies examining the relationship of myosteatosis and mortality among older individuals recruited without regard to their health status are sparse. METHODS: We evaluated the association of peripheral computed tomography measured calf myosteatosis (intermuscular fat and muscle density as a measure of intramuscular fat) with mortality in 1,063 community-dwelling older men...
September 2015: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/25750996/accumulation-of-advanced-glycation-end-products-and-activation-of-the-scap-srebp-lipogenetic-pathway-occur-in-diet-induced-obese-mouse-skeletal-muscle
#16
Raffaella Mastrocola, Massimo Collino, Debora Nigro, Fausto Chiazza, Giuseppe D'Antona, Manuela Aragno, Marco A Minetto
Aim of this study was to investigate whether advanced glycation end-products (AGEs) accumulate in skeletal myofibers of two different animal models of diabesity and whether this accumulation could be associated to myosteatosis. Male C57Bl/6j mice and leptin-deficient ob/ob mice were divided into three groups and underwent 15 weeks of dietary manipulation: standard diet-fed C57 group (C57, n = 10), high-fat high-sugar diet-fed C57 group (HFHS, n = 10), and standard diet-fed ob/ob group (OB/OB, n = 8). HFHS mice and OB/OB mice developed glycometabolic abnormalities in association with decreased mass of the gastrocnemius muscle, fast-to-slow transition of muscle fibers, and lipid accumulation (that occurred preferentially in slow compared to fast fibers)...
2015: PloS One
https://www.readbyqxmd.com/read/25197650/variability-in-myosteatosis-and-insulin-resistance-induced-by-high-fat-diet-in-mouse-skeletal-muscles
#17
Massimo Collino, Raffaella Mastrocola, Debora Nigro, Fausto Chiazza, Manuela Aragno, Giuseppe D'Antona, Marco A Minetto
Nutrient overload leads to impaired muscle oxidative capacity and insulin sensitivity. However, comparative analyses of the effects of dietary manipulation on skeletal muscles with different fiber composition are lacking. This study aimed to investigate the selective adaptations in the soleus and tibialis anterior muscles evoked by administration of high-fat diet for 12 weeks in 10 mice (HFD mice) compared to 10 animals fed with a normal chow diet (control mice). Mice fed with the HFD diet exhibited hyperlipidemia, hyperinsulinemia, hyperglycemia, and lower exercise capacity in comparison to control mice...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24869970/role-of-n-3-fatty-acids-in-muscle-loss-and-myosteatosis
#18
REVIEW
Julia B Ewaschuk, Alaa Almasud, Vera C Mazurak
Image-based methods such as computed tomography for assessing body composition enables quantification of muscle mass and muscle density and reveals that low muscle mass and myosteatosis (fat infiltration into muscle) are common in people with cancer. Myosteatosis and low muscle mass have emerged as independent risk factors for mortality in cancer; however, the characteristics and pathogenesis of these features have not been resolved. Muscle depletion is associated with low plasma eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) in cancer and supplementation with n-3 fatty acids has been shown to ameliorate muscle loss and myosteatosis in clinical studies, suggesting a relationship between n-3 fatty acids and muscle health...
June 2014: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/23809667/myosteatosis-and-myofibrosis-relationship-with-aging-inflammation-and-insulin-resistance
#19
Elena Zoico, Francesca Corzato, Clara Bambace, Andrea P Rossi, Rocco Micciolo, Saverio Cinti, Tamara B Harris, Mauro Zamboni
The mechanisms impairing muscle quality and leading to myofibrosis (MF) and myosteatosis (MS) are incompletely known. In biopsies of paraspinous muscle (PM) of 16 elderly men undergoing elective vertebral surgery, we histologically determined the area of MF and MS expressed as muscle quality index (MQI), in order to investigate the relation between them, as well as the main predictors of muscle quality. Total PM area and intermuscular adipose tissue (IMAT) were evaluated by MRI and body composition by DXA. Circulating fasting glucose, insulin, hs-CRP, leptin, adiponectin and IL-6 were measured and HOMA index calculated...
November 2013: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/23575206/sarcopenia-or-muscle-modifications-in-neurologic-diseases-a-lexical-or-patophysiological-difference
#20
REVIEW
S Carda, C Cisari, M Invernizzi
Sarcopenia is a condition characterized by a decrease in muscle mass and function (strength and mobility) that is frequently observed in the elderly. In people with paresis and altered mobility due to central nervous system (CNS) diseases, this definition then may not be applicable. In CNS diseases, mainly stroke and spinal cord injury, different and specific patterns of muscle loss and muscle changes have been described, due to denervation, disuse atrophy, spasticity and myosteatosis. The main observations available about these phenomena in CNS diseases are reviewed, and a broad view on the specific physiopathological mechanisms is also described...
February 2013: European Journal of Physical and Rehabilitation Medicine
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