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https://www.readbyqxmd.com/read/27911336/decreased-aerobic-capacity-in%C3%A2-ano5-muscular-dystrophy
#1
Emil Ylikallio, Mari Auranen, Ibrahim Mahjneh, Antti Lamminen, Maria Kousi, Ann-Liz Träskelin, Tiina Muurinen, Mervi Löfberg, Tapani Salmi, Anders Paetau, Anna-Elina Lehesjoki, Päivi Piirilä, Sari Kiuru-Enari
BACKGROUND: Anoctaminopathies are muscle diseases caused by recessive mutations in the ANO5 gene. The effects of anoctaminopathy on oxidative capacity have not previously been studied in a controlled setting. OBJECTIVE: To characterize oxidative capacity in a clinically and genetically well-defined series of patients with anoctaminopathy. METHODS: We sequenced the ANO5 gene in 111 Finnish patients with suspected LGMD2. Patients with positive findings underwent close clinical examination, including electromyography, muscle MRI, and, in selected cases, muscle biopsy...
November 29, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27909717/restorative-effects-of-hydroxysafflor-yellow%C3%A2-a-on-hepatic-function-in-an-experimental-regression-model-of-hepatic-fibrosis-induced-by-carbon-tetrachloride
#2
Yanuo Li, Yan Shi, Yan Sun, Luying Liu, Xianyong Bai, Dong Wang, Hongxing Li
Hepatic fibrosis is a reversible pathological process, in which fibrotic tissue is excessively deposited in the liver during the repair process that follows hepatic injury. Early prevention or treatment of hepatic fibrosis has great significance on the treatment of chronic hepatic diseases. Hydroxysafflor yellow A (HSYA) is a water-soluble monomer extracted from safflower, which serves numerous pharmacological roles. However, it remains to be elucidated how HSYA regulates hepatic fibrogenesis. The aim of the present study was to reveal the possible mechanisms underlying the effects of HSYA on the prevention and treatment of hepatic fibrosis...
November 24, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27909128/the-development-of-a-quantitative-scoring-system-to-predict-whether-a-large-to-massive-rotator-cuff-tear-can-be-arthroscopically-repaired
#3
S-J Kim, J-S Park, K-H Lee, B-G Lee
AIMS: The aim of the study was to develop a quantitative scoring system to predict whether a large-to-massive rotator cuff tear was arthroscopically reparable prior to surgery. PATIENTS AND METHODS: We conducted a retrospective review of the pre-operative MR imaging and surgical records of 87 patients (87 shoulders) who underwent arthroscopic repair of a large-to-massive rotator cuff tear. Patients were divided into two groups, based on the surgical outcome of the repair...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27908782/adaptive-responses-of-neuronal-mitochondria-to-bioenergetic-challenges-roles-in-neuroplasticity-and-disease-resistance
#4
REVIEW
Sophia M Raefsky, Mark P Mattson
An important concept in neurobiology is "neurons that fire together, wire together" which means that the formation and maintenance of synapses is promoted by activation of those synapses. Very similar to the effects of the stress of exercise on muscle cells, emerging findings suggest that neurons respond to activity by activating signaling pathways (e.g., Ca(2+), CREB, PGC-1α, NF-κB) that stimulate mitochondrial biogenesis and cellular stress resistance. These pathways are also activated by aerobic exercise and food deprivation, two bioenergetic challenges of fundamental importance in the evolution of the brains of all mammals, including humans...
November 28, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27900313/semitendinosus-and-gracilis-free-muscle-tendon-graft-for-repair-of-massive-rotator-cuff-tears-surgical-technique
#5
Antonio Gigante, Carlo Bottegoni, Giuseppe Milano, Michele Riccio, Luca Dei Giudici
Massive rotator cuff tears are difficult to treat surgically due to retraction, degeneration and fraying of the ends of torn tendons, severe fatty infiltration and atrophy of the respective muscles. Procedures developed to close the gap between the rotator cuff and the greater tuberosity of the humerus, such as soft tissue release may be inadequate for large tears. Human or porcine dermal allografts still have uncertain benefits, and tendon transfers seem to be associated with poor outcomes, donor site morbidity and altered mechanics...
July 2016: Joints
https://www.readbyqxmd.com/read/27896393/degree-of-tendon-degeneration-and-stage-of-rotator-cuff-disease
#6
Chris Hyunchul Jo, Won Hyoung Shin, Ji Wan Park, Ji Sun Shin, Ji Eun Kim
PURPOSE: While tendon degeneration has been known to be an important cause of rotator cuff disease, few studies have objectively proven the association of tendon degeneration and rotator cuff disease. The purpose of this study was to investigate changes of tendon degeneration with respect to the stage of rotator cuff disease. METHODS: A total of 48 patients were included in the study: 12 with tendinopathy, 12 with a partial-thickness tear (pRCT), 12 with a full-thickness tear (fRCT), and 12 as the control...
November 28, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27883274/impact-of-the-chronic-omega-3-fatty-acids-supplementation-in-hemiparkinsonism-model-induced-by-6-hydroxydopamine-in-rats
#7
Alexandre Sales Barros, Rafael Yuri Gouveia Crispim, Juliana Cavalcante Uchoa, Ricardo Basto Souza, Jonatas Cavalcante Lemos, Gerardo Cristino Filho, Mirna Marques Bezerra, Thales Fontenele Moraes Pinheiro, Silvânia Maria Mendes de Vasconcelos, Danielle Silveira Macêdo, Glauce Socorro de Barros Viana, Lissiana Magna Vasconcelos Aguiar
Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra. The neuronal degeneration may result from the convergence of a number of different pathogenic factors, including apoptosis, excitotoxicity and oxidative stress. Many studies emphasize the importance of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in vital processes such as maintenance of the properties of cell membranes and the participation in signal transduction and biodynamic activity of neuronal membranes...
November 24, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27881439/optimisation-of-high-quality-total-ribonucleic-acid-isolation-from-cartilaginous-tissues-for-real-time-polymerase-chain-reaction-analysis
#8
M Peeters, C L Huang, L A Vonk, Z F Lu, R A Bank, M N Helder, B Zandieh Doulabi
OBJECTIVES: Studies which consider the molecular mechanisms of degeneration and regeneration of cartilaginous tissues are seriously hampered by problematic ribonucleic acid (RNA) isolations due to low cell density and the dense, proteoglycan-rich extracellular matrix of cartilage. Proteoglycans tend to co-purify with RNA, they can absorb the full spectrum of UV light and they are potent inhibitors of polymerase chain reaction (PCR). Therefore, the objective of the present study is to compare and optimise different homogenisation methods and RNA isolation kits for an array of cartilaginous tissues...
November 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27879506/fatty-degeneration-of-the-paraspinal-muscle-in-patients-with-degenerative-lumbar-kyphosis-a-new-evaluation-method-of-quantitative-digital-analysis-using-mri-and-ct-scan
#9
Seung-Jae Hyun, Chae-Wan Bae, Sang-Hoon Lee, Seung-Chul Rhim
STUDY DESIGN: A comparative case-control study. OBJECTIVE: The aim of this study was to quantify the degree of paraspinal muscle changes in degenerative lumbar kyphosis (DLK) patients using magnetic resonance imaging and computed tomography scanning. SUMMARY OF BACKGROUND DATA: Although the pathophysiology of DLK is not completely understood, extensive degeneration and weakness of the lumbar extensor muscles are thought to underlie the condition in most patients...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27876965/histopathological-study-of-gill-kidney-and-liver-of-persian-sturgeon-acipenser-persicus-borodin-1897-and-stellate-acipenser-stellatus-pallas-1811-exposed-to-sublethal-concentration-of-un-ionised-ammonia-uan
#10
Elham Sadat Banihashemi, Hossein Khara, Zabiyollah Pajand, Mohammad Rahnandeh
This study was carried out to investigate the histopathological changes of gill, kidney and liver of Persian Sturgeon and Stellate in response to various sublethal concentration of ammonia. The sublethal doses were determined after a lethal pre-test and then the experiment was done in six treatments with three replicates for both species. In Persian sturgeon, the treatments were including 5, 7, 9.7, 13.2, 18 and 25 mg/l ammonia. In stellate, the concentrations of 5, 6.23, 7.76, 9.66, 12.04 and 15 mg/l ammonia were considered as treatments...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27874200/two-patients-with-gmppb-mutation-the-overlapping-phenotypes-of-limb-girdle-myasthenic-syndrome-and-lgmd2t-dystroglycanopathy
#11
Federica Montagnese, Elisabeth Klupp, Dimitrios C Karampinos, Saskia Biskup, Dieter Gläser, Jan S Kirschke, Benedikt Schoser
INTRODUCTION: Mutations in the GDP-mannose pyrophosphorylase-B gene (GMPPB) have been identified in congenital muscular dystrophies (CMDs), limb-girdle muscular dystrophy (LGMD2T), and congenital myasthenic syndromes (CMSs); overall, 41 patients have been described. METHODS: Two patients presented with a myasthenic syndrome (patient 1, 74-year-old) and rhabdomyolysis (patient 2, 23-year-old). Examinations included repetitive nerve stimulation, muscle biopsy and whole-body MRI (WBMRI); next generation sequencing facilitated diagnosis...
November 22, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27858677/intra-and-interreliability-of-histographic-analysis-for-paraspinal-muscle-degeneration-in-patients-with-unilateral-back-pain-using-magnetic-resonance-imaging
#12
Dong-Won Suh, Yushin Kim, Minyoung Lee, Seungcheol Lee, Sung Jun Park, BumChul Yoon
BACKGROUND: Mixed use of T1- or T2-weighted magnetic resonance imaging (MRI) in histographic analysis has impeded cross-reference of studies on fatty degeneration of muscles in patients with back pain. OBJECTIVE: The current study aimed to establish the measurement reliability of histographic analysis for normal and painful paraspinal muscles between T1- and T2-weighted MRI. METHODS: T1- and T2-weighted MRI at the L4-5 level were performed in 31 patients with unilateral back pain...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27852305/schisandra-polysaccharide-inhibits-hepatic-lipid-accumulation-by-downregulating-expression-of-srebps-in-nafld-mice
#13
Chun-Mei Wang, Rong-Shuang Yuan, Wen-Yue Zhuang, Jing-Hui Sun, Jin-Ying Wu, He Li, Jian-Guang Chen
BACKGROUND: Hepatoprotective effects of Chinese herbal medicine Schisandra Chinensis (Schisandra) have been widely investigated. However, most studies were focused on its lignan extracts. We investigated the effects of Schisandra polysaccharide (SCP) in a mouse model of non-alcoholic fatty liver disease (NAFLD), and studied its effect on sterol regulatory element binding proteins (SREBPs) and the related genes. METHODS: The mouse model of NAFLD was established by feeding mice with a high-fat diet for 16 weeks...
November 16, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27842621/the-effect-of-age-and-castration-on-the-growth-rate-blood-lipid-profile-liver-histology-and-feed-conversion-in-green-legged-partridge-cockerels-and-capons
#14
M Zawacka, D Murawska, M Gesek
The surgical castration of male chickens induces hormonal changes, which permanently influence metabolic processes in birds. The aim of this study was to determine the effect of age and castration on the growth rate, feed conversion, lipid profile and histopathological changes in the livers of cockerels and capons. The experimental materials comprised male chickens of the Green-legged Partridge breed (old traditional Polish chicken breed), raised to 28 weeks of age. At 8 weeks of age, 100 birds were castrated...
November 15, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27834813/the-potential-of-non-provitamin-a-carotenoids-for-the-prevention-and-treatment-of-non-alcoholic-fatty-liver-disease
#15
REVIEW
Ana Gabriela Murillo, Diana M DiMarco, Maria Luz Fernandez
Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated spectrum of comorbidities defined by the presence of metabolic dysfunction, oxidative stress, inflammation, and fibrosis in the liver. If left untreated, NAFLD can progress to cirrhosis, liver failure, or hepatocellular carcinoma. NAFLD is recognized as the most common liver disease in the United States, affecting around 30% of the population. Identification of dietary components capable of reducing or preventing NAFLD is therefore essential to battle this condition...
November 8, 2016: Biology
https://www.readbyqxmd.com/read/27806561/4-hydroxy-7-oxo-5-heptenoic-acid-hoha-lactone-induces-angiogenesis-through-several-different-molecular-pathways
#16
Junhong Guo, Mikhail D Linetsky, Annabelle O Yu, Liang Zhang, Scott J Howell, Heather J Folkwein, Hua Wang, Robert G Salomon
Oxidative stress and angiogenesis have been implicated not only in normal phenomena such as tissue healing and remodeling but also in many pathological processes. However, the relationships between oxidative stress and angiogenesis still remain unclear, although oxidative stress has been convincingly demonstrated to influence the progression of angiogenesis under physiological and pathological conditions. The retina is particularly susceptible to oxidative stress owing to its intensive oxygenation and high abundance of polyunsaturated fatty acyls...
November 3, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27803226/suprascapular-neuropathy-in-massive-rotator-cuff-tears-with-severe-fatty-degeneration-in-the-infraspinatus-muscle
#17
B Y Kong, S H Kim, D H Kim, H Y Joung, Y H Jang, J H Oh
AIMS: Our aim was to describe the atypical pattern of increased fatty degeneration in the infraspinatus muscle compared with the supraspinatus in patients with a massive rotator cuff tear. We also wished to describe the nerve conduction and electromyography findings in these patients. PATIENTS AND METHODS: A cohort of patients undergoing surgery for a massive rotator cuff tear was identified and their clinical records obtained. Their MRI images were reviewed to ascertain the degree of retraction of the torn infraspinatus and supraspinatus muscles, and the degree of fatty degeneration in both muscles was recorded...
November 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27785930/evaluation-of-paravertebral-muscle-atrophy-and-fatty-degeneration-in-ankylosing-spondylitis
#18
Hatice Resorlu, Yılmaz Savas, Nilufer Aylanc, Ferhat Gokmen
AIM: The purpose of this study was to assess morphological changes in the paravertebral muscles in patients with ankylosing spondylitis. MATERIALS AND METHODS: Fifty-one patients diagnosed with ankylosing spondylitis and a 50 member control group were included in the study. The surface area of the multifidus and erector spinae muscles was measured at four levels between L1 and L5, and fatty degeneration in these muscles was scored. Lumbosacral and lumbar lordotic angles were determined for the patient and control groups...
October 27, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27777813/the-etiology-and-pathogenesis-of-kienb%C3%A3-ck-disease
#19
Gregory Ian Bain, Simon Bruce Murdoch MacLean, Chong Jin Yeo, Egon Perilli, David M Lichtman
Kienböck disease is a condition that typically occurs in the "at-risk" patient, in the "at-risk" aspect of the proximal condyle of the "at-risk" lunate. In the active male, repetitive loading causes the stress fracture that commences in the single layer proximal subchondral bone plate. The lunate fracture commences at the point the lunate cantilevers over the edge of the distal radius, and then takes on the shape of the radius. We postulate that the stress fracture violates the parallel veins of the venous subarticular plexus-leading to localized venous hypertension and subsequent ischemia and edema of the fatty marrow...
November 2016: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/27771292/ceramidases-roles-in-sphingolipid-metabolism-and-in-health-and-disease
#20
Nicolas Coant, Wataru Sakamoto, Cungui Mao, Yusuf A Hannun
Over the past three decades, extensive research has been able to determine the biologic functions for the main bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate (S1P) (Hannun, 1996; Hannun et al., 1986; Okazaki et al., 1989). These studies have managed to define the metabolism, regulation, and function of these bioactive sphingolipids. This emerging body of literature has also implicated bioactive sphingolipids, particularly S1P and ceramide, as key regulators of cellular homeostasis...
October 11, 2016: Advances in Biological Regulation
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