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https://www.readbyqxmd.com/read/28542102/influence-of-paravertebral-muscle-quality-on-treatment-efficacy-of-epidural-steroid-infiltration-or-surgical-decompression-in-lumbar-spinal-stenosis-analysis-of-the-lumbar-spinal-outcome-study-lsos-data-a-swiss-prospective-multi-center-cohort-study
#1
Michael Betz, Jakob M Burgstaller, Ulrike Held, Gustav Andreisek, Johann Steurer, Francois Porchet, Mazda Farshad
STUDY DESIGN: Prospective multi-center cohort study. OBJECTIVE: To study the question whether paravertebral muscle quality may affect the clinical outcome of epidural steroid infiltration (ESI) or surgical decompression in patients with symptomatic lumbar spinal stenosis (LSS). SUMMARY OF BACKGROUND DATA: To the present, the impact of paravertebral muscle quality on clinical outcome of epidural steroid infiltration (ESI) or surgical decompression in patients with lumbar spinal stenosis (LSS) has not been clarified...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28515072/%C3%AF-3-and-%C3%AF-6-long-chain-pufas-and-their-enzymatic-metabolites-in-neovascular-eye-diseases
#2
REVIEW
Yan Gong, Zhongjie Fu, Raffael Liegl, Jing Chen, Ann Hellström, Lois Eh Smith
Neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration, threaten the visual health of children and adults. Current treatment options, including anti-vascular endothelial growth factor therapy and laser retinal photocoagulation, have limitations and are associated with adverse effects; therefore, the identification of additional therapies is highly desirable. Both clinical and experimental studies show that dietary ω-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFAs) reduce retinal and choroidal angiogenesis...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28509823/progression-of-fatty-muscle-degeneration-in-atraumatic-rotator-cuff-tears
#3
Jonah Hebert-Davies, Sharlene A Teefey, Karen Steger-May, Aaron M Chamberlain, William Middleton, Kathryn Robinson, Ken Yamaguchi, Jay D Keener
BACKGROUND: The purpose of this prospective study was to examine the progression of fatty muscle degeneration over time in asymptomatic shoulders with degenerative rotator cuff tears. METHODS: Subjects with an asymptomatic rotator cuff tear in 1 shoulder and pain due to rotator cuff disease in the contralateral shoulder were enrolled in a prospective cohort. Subjects were followed annually with shoulder ultrasonography, which evaluated tear size, location, and fatty muscle degeneration...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28505492/comprehensive-evaluation-of-scfa-production-in-the-intestinal-bacteria-regulated-by-berberine-using-gas-chromatography-combined-with-polymerase-chain-reaction
#4
Lu-Lu Wang, Hui-Hui Guo, Shuai Huang, Chen-Lin Feng, Yan-Xing Han, Jian-Dong Jiang
Short-chain fatty acids (SCFAs) of intestine microbial have caught accumulating attention for their beneficial effects on human health. Botanic compounds with low bioavailability such as berberine (BBR) and resveratrol might interact with intestinal microbial ecosystem and promote gut bacteria to produce SCFA, which contribute to their biological effects. In the present study, a comprehensive assay system was built to detect SCFAs production in intestinal bacteria, in which stringent anaerobic culture was applied for in vitro bacterial fermentation, followed by direct-injection GC detection (chemical detection) in combination with real time polymerase chain reaction (RT-PCR, biological detection)...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28496357/incidence-and-risk-factors-of-persistent-low-back-pain-following-posterior-decompression-and-instrumented-fusion-for-lumbar-disk-herniation
#5
Hui Wang, Tao Wang, Qian Wang, Wenyuan Ding
INTRODUCTION: The aim of this study was to explore the incidence and risk factors of persistent low back pain (PLBP) following posterior decompression and instrumented fusion for lumbar disk herniation and to provide references in decision-making and surgical planning for both spinal surgeons and surgically treated patients. PATIENTS AND METHODS: By retrieving the medical records from January 2013 to December 2016, 221 patients were retrospectively reviewed. Patients were classified as having PLBP if numeric rating scale (NRS) scores were >50 at all postoperative follow-up time points (3 months, 6 months, and 12 months)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28495576/quantitative-assessment-of-fatty-infiltration-and-muscle-volume-of-the-rotator-cuff-muscles-using-3-dimensional-2-point-dixon-magnetic-resonance-imaging
#6
Noboru Matsumura, Sota Oguro, Shigeo Okuda, Masahiro Jinzaki, Morio Matsumoto, Masaya Nakamura, Takeo Nagura
BACKGROUND: In patients with rotator cuff tears, muscle degeneration is known to be a predictor of irreparable tears and poor outcomes after surgical repair. Fatty infiltration and volume of the whole muscles constituting the rotator cuff were quantitatively assessed using 3-dimensional 2-point Dixon magnetic resonance imaging. METHODS: Ten shoulders with a partial-thickness tear, 10 shoulders with an isolated supraspinatus tear, and 10 shoulders with a massive tear involving supraspinatus and infraspinatus were compared with 10 control shoulders after matching age and sex...
May 8, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28494547/-dynamic-expression-of-carnitine-palmitoyltransferase-ii-in-the-mitochondrial-inner-membrane-during-hepatocyte-malignant-transformation-induced-by-lipid-accumulation
#7
J J Gu, M Yao, Y Cai, M Fang, L Wang, W J Zheng, D B Yao, Z Z Dong, D F Yao
Objective: To investigate the dynamic expression of hepatic carnitine palmitoyltransferase-II (CPT-II) in the mitochondrial inner membrane during hepatocyte malignant transformation induced by lipid accumulation. Methods: Male Sprague-Dawley rats were divided randomly into control, fatty liver, and induced cancer groups, which were fed with normal, high-fat (HF), and HF containing 2-fluorenylacetamide (0.05%, 2-FAA) diets, respectively, for 14 weeks. One rat from each group was sacrificed every two weeks and the blood and liver samples were collected...
April 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28490965/protective-effects-of-fennel-oil-extract-against-sodium-valproate-induced-hepatorenal-damage-in-albino-rats
#8
Wael M Al-Amoudi
Foeniculum vulgare (Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28488622/family-with-ehlers-danlos-syndrome-combined-classic-and-vascular-type-with-rare-presentation-of-progressive-myopathy-and-unusual-association-of-severe-facial-and-trigeminal-motor-weakness
#9
A Nalini, N Devaraddi, N Gayathri, Chandrajit Prasad, V Preethish-Kumar, K Polavarapu, S Shantanu
We report the clinical, radiological, biochemical, muscle histology, and electron microscopic features of two members of a family with combined Ehlers-Danlos syndrome (EDS) [classic and vascular type] and progressive myopathy as the primary manifestation. A 35-year old lady presented with severe gluteal and thigh muscle pain and easy fatigability for 5 years. She developed weakness and wasting of pelvic and pectoral girdles and thighs for 3 years and severe neck flexor and truncal weakness for 6 months. She had a history of recurrent jaw dislocation, easy bruising with hyperpigmentation, hyperextensibility of joints, translucent skin, and papyraceous scars...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28485676/assessment-of-preclinical-liver-and-skeletal-muscle-biomarkers-following-clofibrate-administration-in-wistar-rats
#10
Pierre Maliver, Matthias Festag, Moritz Bennecke, Francois Christen, Balázs Bánfai, Barbara Lenz, Michael Winter
Clofibrate is a known rodent hepatotoxicant classically associated with hepatocellular hypertrophy and increased serum activities of cellular alanine aminotransferase/aspartate aminotransferase (ALT/AST) in the absence of microscopic hepatocellular degeneration. At toxic dose, clofibrate induces liver and skeletal muscle injury. The objective of this study was to assess novel liver and skeletal muscle biomarkers following clofibrate administration in Wistar rats at different dose levels for 7 days. In addition to classical biomarkers, liver injury was assessed by cytokeratin 18 (CK18) cleaved form, high-mobility group box 1, arginase 1 (ARG1), microRNA 122 (miR-122), and glutamate dehydrogenase...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28481011/omega-3-fatty-acids-in-prevention-of-diabetic-retinopathy
#11
REVIEW
Tapan Behl, Anita Kotwani
OBJECTIVES: To review the competence of Omega-3 fatty acids in restricting the progression, thereby leading to prevention of diabetic retinopathy. KEY FINDINGS: Owing to their anti-inflammatory and anti-angiogenic properties, Omega-3 fatty acids alleviate major aetiological agents. These fatty acids are renowned for their beneficial effects in various cardiovascular and other disorders; however, their potential to prevent the progression of diabetic retinopathy remains least explored...
May 8, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28468892/dietary-intake-of-%C3%AE-linolenic-acid-and-risk-of-age-related-macular-degeneration
#12
Juan Wu, Eunyoung Cho, Edward L Giovannucci, Bernard A Rosner, Srinivas M Sastry, Debra A Schaumberg, Walter C Willett
Background: The relation between α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and age-related macular degeneration (AMD) is unclear. European researchers reported that ≤40% of ALA can be present as trans forms.Objective: We aimed to evaluate the associations between intake of ALA and intermediate and advanced AMD.Design: Seventy-five thousand eight hundred eighty-nine women from the Nurses' Health Study and 38,961 men from Health Professionals Follow-Up Study were followed up from 1984 to 2012 and from 1986- to 2010, respectively...
May 3, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28465557/one-year-daily-consumption-of-buttermilk-drink-containing-lutein-enriched-egg-yolks-does-not-affect-endothelial-function-in-fasting-and-postprandial-state
#13
Sanne M van der Made, Tos T J M Berendschot, Aize Kijlstra, Jogchum Plat
Previous results have shown that one-year daily consumption of a lutein-enriched egg yolk containing dairy drink did not significantly affect fasting serum lipid and lipoprotein concentrations in adults with early signs of macular degeneration. The current study further substantiates these findings with parameters reflecting endothelial function. Additionally, we extend our observations from the fasting to the postprandial situation. Subjects participated in a 1-y randomized placebo-controlled dietary intervention trial...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28465000/long-term-soft-drink-and-aspartame-intake-induces-hepatic-damage-via-dysregulation-of-adipocytokines-and-alteration-of-the-lipid-profile-and-antioxidant-status
#14
Mohamed A Lebda, Hossam G Tohamy, Yasser S El-Sayed
Dietary intake of fructose corn syrup in sweetened beverages is associated with the development of metabolic syndrome and obesity. We hypothesized that inflammatory cytokines play a role in lipid storage and induction of liver injury. Therefore, this study intended to explore the expression of adipocytokines and its link to hepatic damage. Rats were assigned to drink water, cola soft drink (free access) and aspartame (240 mg/kg body weight/day orally) for 2 months. The lipid profiles, liver antioxidants and pathology, and mRNA expression of adipogenic cytokines were evaluated...
April 19, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28459020/disruption-of-angiogenesis-by-anthocyanin-rich-extracts-of-hibiscus-sabdariffa
#15
Madu Joshua, Christiana Okere, O'Donnell Sylvester, Muhammad Yahaya, Omale Precious, Thagriki Dluya, Ji-Yeon Um, Musa Neksumi, Jessica Boyd, Jennifer Vincent-Tyndall, Dong-Won Choo, Diana R Gutsaeva, Wan Jin Jahng
Abnormal vessel formations contribute to the progression of specific angiogenic diseases including age-related macular degeneration. Adequate vessel growth and maintenance represent the coordinated process of endothelial cell proliferation, matrix remodeling, and differentiation. However, the molecular mechanism of the proper balance between angiogenic activators and inhibitors remains elusive. In addition, quantitative analysis of vessel formation has been challenging due to complex angiogenic morphology. We hypothesized that conjugated double bond containing-natural products, including anthocyanin extracts from Hibiscus sabdariffa, may control the proper angiogenesis...
February 2017: International Journal of Scientific and Engineering Research
https://www.readbyqxmd.com/read/28458803/neuromuscular-disorder-as-initial-manifestation-of-secondary-hyperparathyroidism-a-case-report
#16
Karim Hajjar, Tim Hagenacker
This case report describes a young woman who presented with slowly progressing weakness of the proximal limb muscles and slight decrease of muscle tone but otherwise unremarkable neurological history. Diagnostic workup revealed fatty degeneration of the girdle muscles and an excessive increase of the parathyroid hormone as a result of severe vitamin D deficiency. Secondary hyperparathyroidism was diagnosed, and neurological deficits resolved after treatment of the underlying endocrinopathy.
February 24, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28458350/therapeutic-effect-of-gypenosides-on-nonalcoholic-steatohepatitis-via-regulating-hepatic-lipogenesis-and-fatty-acid-oxidation
#17
Hongshan Li, Hao Ying, Airong Hu, Yaoren Hu, Dezhou Li
Nonalcoholic steatohepatitis (NASH) is the most frequent cause of liver dysfunction and a common global problem. Gypenosides can decrease pathological modifications of high-fat diet-induced rat atherosclerosis; however, its effect and mechanism on NASH remain unclear. In this study, rats were randomly divided into normal control and model groups. Model rats were fed with a high-fat diet and treated with gypenosides, rosiglitazone, or water for 6 weeks. We found that liver tissues showed significant hepatic steatosis and vacuolar degeneration with significantly higher triglyceride (TG), free fatty acid (FFA) and malonyl CoA, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) activities in model group versus normal control group (p<0...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28454720/a-two-year-dietary-carcinogenicity-study-of-cyadox-in-sprague-dawley-rats
#18
Qianying Liu, Zhixin Lei, Luqing Cui, Jianwu Zhang, Ihsan Awais, Menghong Dai, Xu Wang, Zonghui Yuan
To investigate the potential carcinogenicity of cyadox, an antimicrobial agent, four groups of Sprague-Dawley rats (50 rats/sex/group) were fed diets containing cyadox (0, 200, 600 or 2000 mg/kg) for up to two years. There were significant decreases in body weight, feed intake and feed efficiency in both genders during most of the period in the 2000 mg/kg group. Significant decreases in serum ALT were observed in the 2000 mg/kg group at weeks 52, 78 and 104. For the control, 200, 600, and 2000 mg/kg groups, the tumor incidence in females was 33...
April 25, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28434974/proteomic-approach-to-detect-changes-in-hippocampal-protein-levels-in-an-animal-model-of-type-2-diabetes
#19
Sung Min Nam, Dae Young Yoo, Hyun Jung Kwon, Jong Whi Kim, Hyo Young Jung, Dae Won Kim, Ho Jae Han, Moo-Ho Won, Je Kyung Seong, In Koo Hwang, Yeo Sung Yoon
In our previous study, we demonstrated that type 2 diabetes affects blood-brain barrier integrity and ultrastructural morphology in Zucker diabetic fatty (ZDF) rats at 40 weeks of age. In the present study, we investigated the possible candidates for diabetes-related proteins in the hippocampus of ZDF rats and their control littermates (Zucker lean control, ZLC), by using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF)...
April 21, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28409152/the-association-between-imaging-parameters-of-the-paraspinal-muscles-spinal-degeneration-and-low-back-pain
#20
REVIEW
Leonid Kalichman, Eli Carmeli, Ella Been
This narrative review investigated imaging parameters of the paraspinal muscles and their association with spinal degenerative features and low back pain (LBP) found in the literature. Three principal signs of muscle degeneration were detected on imaging: decreased muscle size, decreased radiographic density, and increased fat deposits. Men have a higher density of paraspinal muscles than women, younger individuals have a higher density than older ones, and lean individuals have a higher density than those with an increased body mass index...
2017: BioMed Research International
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