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https://www.readbyqxmd.com/read/29338908/relationship-between-neuropathy-proximal-to-the-suprascapular-nerve-and-rotator-cuff-tear-in-a-rodent-model
#1
Yasuhito Sasaki, Nobuyasu Ochiai, Eiko Hashimoto, Yu Sasaki, Takeshi Yamaguchi, Takehiro Kijima, Koji Akimoto, Seiji Ohtori, Kazuhisa Takahashi
BACKGROUND: Rotator cuff tears are believed to coexist with cervical spine lesions. In cases of preexisting neuropathy, such as cervical spine lesions, fatty degeneration has likely already occurred due to the neuropathy. In these cases, rotator cuff tear is thought to occur easily because of preexisting extensive fatty degeneration and degeneration of the tendons due to neuropathy. This study aimed to evaluate the effects of paralysis due to neuropathy proximal to the suprascapular nerve on the supraspinatus and infraspinatus tendons using a rat model of brachial plexus paralysis...
January 12, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29337028/bipolar-pedicled-teres-major-transfer-for-irreparable-subscapularis-tendon-tears-an-anatomic-feasibility-study
#2
Thibault Lafosse, Malo Le Hanneur, Julia Lee, Bassem Elhassan
BACKGROUND: Subscapularis (SSC) tendon tears are a challenging problem because they can significantly alter shoulder mechanics and function. Tendon retraction and advanced fatty degeneration associated with a chronic tear may make it irreparable. Tendon transfers options for such tears are viable, but results in the setting of associated glenohumeral instability are inconsistent. With the potential to recreate the SSC line of pull, the teres major (TM) may be a viable option for transfer...
January 12, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29335916/association-between-obstructive-sleep-apnea-and-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#3
REVIEW
Shanshan Jin, Suwen Jiang, Airong Hu
The relationship between obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) has been an issue of great concern. The primary purpose of this study was to determine the influence of OSA on the levels of liver enzymes including alanine transaminase (ALT) and aspartate transaminase (AST). The secondary purpose was to estimate the effect of OSA on the histological lesions of NAFLD, such as steatosis, lobular inflammation, ballooning degeneration, fibrosis, as well as NAFLD activity score (NAS)...
January 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29327070/-open-repair-of-gluteus-medius-and-minimus-tendons-tears-with-double-row-technique-clinical-and-radiological-results
#4
J H Schröder, M Geßlein, M Schütz, C Perka, D Krüger
BACKGROUND: Operative refixation is a new therapeutic option in cases of failed conservative treatment for trochanteric pain syndrome (TPS) and lesions of the hip abductors in magnetic resonance imaging (MRI). OBJECTIVE: Evaluation of the clinical and radiological results after open gluteus medius and minimus tendon reconstruction with a double-row technique was carried out. MATERIAL AND METHODS: Patients with failed conservative treatment for TPS and confirmed lesions of the hip abductors in MRI were treated by open hip abductor tendon reconstruction with a double-row technique...
January 11, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29315315/quantification-of-intramuscular-fat-in-patients-with-late-onset-pompe-disease-by-conventional-magnetic-resonance-imaging-for-the-long-term-follow-up-of-enzyme-replacement-therapy
#5
André Lollert, Clemens Stihl, Andreas M Hötker, Eugen Mengel, Jochem König, Katharina Laudemann, Seyfullah Gökce, Christoph Düber, Gundula Staatz
OBJECTIVE: The objective of this study was to evaluate a quantitative method based on conventional T1-weighted magnetic resonance (MR) imaging to assess fatty muscular degeneration in patients with late-onset Pompe disease and to compare it with semi-quantitative visual evaluation (the Mercuri score). In addition, a long-term retrospective data analysis was performed to evaluate treatment response to enzyme replacement therapy with alglucosidase alfa. METHODS: MR images of the lumbar spine were acquired in 41 patients diagnosed with late-onset Pompe disease from 2006 through 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29290606/isolated-loss-of-active-external-rotation-a-distinct-entity-and-results-of-l-episcopo-tendon-transfer
#6
Pascal Boileau, Mohammed Baba, Walter B McClelland, Charles-Édouard Thélu, Christophe Trojani, Nicolas Bronsard
BACKGROUND: The purpose of this study was to characterize a subgroup of cuff-deficient patients with isolated loss of active external rotation (ILER) but preserved active elevation and to evaluate the outcomes of the L'Episcopo procedure to restore horizontal muscle balance. METHODS: During a 10-year period, 26 patients (14 men, 12 women) were identified with ILER in the setting of massive irreparable posterosuperior cuff tears. A modified L'Episcopo tendon transfer was performed to restore active external rotation and to improve shoulder function...
December 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29282062/supraspinatus-muscle-elasticity-measured-with-real-time-shear-wave-ultrasound-elastography-correlates-with-mri-spectroscopic-measured-amount-of-fatty-degeneration
#7
Fabian Gilbert, Detlef Klein, Andreas Max Weng, Herbert Köstler, Benedikt Schmitz, Jonas Schmalzl, Dirk Böhm
BACKGROUND: Fatty Degeneration (FD) of the rotator cuff muscles influences functional and anatomical outcome after rotator cuff repair. The MRI based estimation of fatty degeneration is the gold standard. There is some evidence that Ultrasound elastography (EUS) can detect local differences of tissue stiffness in muscles and tendons. Shear-wave elastography (SWE) was evaluated to determine the extent to which shear wave velocity was associated with measures of fatty degeneration. MRI-spectroscopic fat measurement was used as a reference to quantify the amount of fat in the muscle belly...
December 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29249316/immunization-of-guinea-pigs-with-salmonella-delivered-anti-brucella-formulation-reduces-organs-bacterial-load-and-mitigates-histopathological-consequences-of-brucella-abortus-544-challenge
#8
Jonathan Lalsiamthara, John Hwa Lee
With an objective to generate safe and effective anti-Brucella vaccine, an attenuated live Salmonella Typhimurium vector delivering heterologous Brucella immunogenic proteins SOD, Omp19, BLS, and PrpA formulated with purified Brucella abortus lipopolysaccharide was evaluated on a guinea pig model. This model represents high susceptibility to Brucella infections and showed similarities in reproducing human pathologies. On safety perspectives, the vaccine formulation induced no observable alterations on general health and histology of the vaccinated guinea pigs...
January 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29242797/lipoma-arborescens-eyes-see-what-mind-knows
#9
Himanshu Gurunath Kulkarni, Gurunath S Kulkarni, Prakash G Kulkarni
Introduction: Lipoma arborescens is a rare lesion, benign in nature and was first described in detail in 1957. <200 cases have been reported in the literature by now. It consists of subsynovial villous proliferation of mature fat cells. Since the incidence of the condition is very rare, definite etiology has not established. Arthroscopic or open synovectomy has been the treatment of choice of the lesion. Case Report: We present you a case of lipomatosis arborescens of the right knee in a 28-year-old male...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29220207/mr-imaging-of-muscle-trauma-anatomy-biomechanics-pathophysiology-and-imaging-appearance
#10
Dyan V Flores, Catalina Mejía Gómez, Mauricio Estrada-Castrillón, Edward Smitaman, Mini N Pathria
Muscle is an important component of the muscle-tendon-bone unit, driving skeletal motion through contractions that alter the length of the muscle. The muscle and myotendinous junction (MTJ) are most commonly injured in the young adult, as a result of indirect mechanisms such as overuse or stretching, direct impact (penetrating or nonpenetrating), or dysfunction of the supporting connective tissues. Magnetic resonance (MR) imaging is widely used for assessment of muscle injuries. This review illustrates the MR imaging appearance of a broad spectrum of acute, subacute, and chronic traumatic lesions of muscle, highlighting the pathophysiology, biomechanics, and anatomic considerations underlying these lesions...
December 8, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29214051/cytochrome-b5-protects-photoreceptors-from-light-stress-induced-lipid-peroxidation-and-retinal-degeneration
#11
Xinping Chen, Hana Hall, Jeffrey P Simpson, Walter D Leon-Salas, Donald F Ready, Vikki M Weake
Lipid peroxides are generated by oxidative stress in cells, and contribute to ageing and neurodegenerative disease. The eye is at special risk for lipid peroxidation because photoreceptors possess amplified sensory membranes rich in peroxidation-susceptible polyunsaturated fatty acids. Light-induced lipid peroxidation in the retina contributes to retinal degeneration, and lipid peroxidation has been implicated in the progression of age-associated ocular diseases such as age-related macular degeneration (AMD)...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29201303/bridging-graft-in-irreparable-massive-rotator-cuff-tears-autogenic-biceps-graft-versus-allogenic-dermal-patch-graft
#12
Sung Min Rhee, Joo Han Oh
Background: Few comparative studies have reported on the use of biologic grafts for irreparable massive rotator cuff tears. The purpose of this study was to assess the results of arthroscopic bridging graft in irreparable massive rotator cuff tears using an autogenic long head of biceps tendon (LHBT) or an allogenic dermal patch (ADP). Methods: We retrospectively reviewed 24 patients treated using the LHBT (group I) and eight patients with complete rupture of the LHBT treated using an ADP (group II) since 2011...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29200733/amelioration-of-intestinal-barrier-dysfunction-by-berberine-in-the-treatment-of-nonalcoholic-fatty-liver-disease-in-rats
#13
Donghao Li, Jimin Zheng, Yiting Hu, Hongtao Hou, Shurong Hao, Na Liu, Yuzhen Wang
Objective: To investigate the effect of berberine (BBR) on intestinal barrier function in nonalcoholic fat liver disease (NAFLD) in rats. Materials and Methods: Rats were divided into three groups: normal diet group (control group [CON group]), high-fat diet feeding group (HFD group), and HFD with BBR group. After 8 weeks of HFD feeding, rats in the BBR group were given BBR intragastrically at a dose of 150 mg/kg daily for 4 weeks. The same volume of normal saline was given to the CON and HFD groups...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200724/bioassay-guided-isolation-of-neuroprotective-fatty-acids-from-nigella-sativa-against-1-methyl-4-phenylpyridinium-induced-neurotoxicity
#14
Leila Hosseinzadeh, Hoda Monaghash, Farahnaz Ahmadi, Nastaran Ghiasvand, Yalda Shokoohinia
Objective: Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant. Materials and Methods: Black cumin, a popular anti-inflammatory and antioxidant food seasoning, contains nonpolar constituents such as FAs which were extracted using hexane...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29193961/chemical-proteomics-reveals-soluble-epoxide-hydrolase-as-a-therapeutic-target-for-ocular-neovascularization
#15
Rania S Sulaiman, Bomina Park, Sardar Pasha Sheik Pran Babu, Yubing Si, Rakshin Kharwadkar, Sayak K Mitter, Bit Lee, Wei Sun, Xiaoping Qi, Michael E Boulton, Samy O Meroueh, Xiang Fei, Seung-Yong Seo, Timothy W Corson
The standard-of-care therapeutics for the treatment of ocular neovascular diseases like wet age-related macular degeneration (AMD) are biologics targeting vascular endothelial growth factor signaling. There are currently no FDA approved small molecules for treating these blinding eye diseases. Therefore, therapeutic agents with novel mechanisms are critical to complement or combine with existing approaches. Here, we identified soluble epoxide hydrolase (sEH), a key enzyme for epoxy fatty acid metabolism, as a target of an antiangiogenic homoisoflavonoid, SH-11037...
December 1, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29183319/ppar%C3%AE-is-essential-for-retinal-lipid-metabolism-and-neuronal-survival
#16
Elizabeth A Pearsall, Rui Cheng, Kelu Zhou, Yusuke Takahashi, H Greg Matlock, Shraddha S Vadvalkar, Younghwa Shin, Thomas W Fredrick, Marin L Gantner, Steven Meng, Zhongjie Fu, Yan Gong, Michael Kinter, Kenneth M Humphries, Luke I Szweda, Lois E H Smith, Jian-Xing Ma
BACKGROUND: Peroxisome proliferator activated receptor-alpha (PPARα) is a ubiquitously expressed nuclear receptor. The role of endogenous PPARα in retinal neuronal homeostasis is unknown. Retinal photoreceptors are the highest energy-consuming cells in the body, requiring abundant energy substrates. PPARα is a known regulator of lipid metabolism, and we hypothesized that it may regulate lipid use for oxidative phosphorylation in energetically demanding retinal neurons. RESULTS: We found that endogenous PPARα is essential for the maintenance and survival of retinal neurons, with Pparα -/- mice developing retinal degeneration first detected at 8 weeks of age...
November 28, 2017: BMC Biology
https://www.readbyqxmd.com/read/29174526/timed-function-tests-motor-function-measure-and-quantitative-thigh-muscle-mri-in-ambulant-children-with-duchenne-muscular-dystrophy-a-cross-sectional-analysis
#17
Simone Schmidt, Patricia Hafner, Andrea Klein, Daniela Rubino-Nacht, Vanya Gocheva, Jonas Schroeder, Arjith Naduvilekoot Devasia, Stephanie Zuesli, Guenther Bernert, Vincent Laugel, Clemens Bloetzer, Maja Steinlin, Andrea Capone, Monika Gloor, Patrick Tobler, Tanja Haas, Oliver Bieri, Thomas Zumbrunn, Dirk Fischer, Ulrike Bonati
The development of new therapeutic agents for the treatment of Duchenne muscular dystrophy has put a focus on defining outcome measures most sensitive to capture treatment effects. This cross-sectional analysis investigates the relation between validated clinical assessments such as the 6-minute walk test, motor function measure and quantitative muscle MRI of thigh muscles in ambulant Duchenne muscular dystrophy patients, aged 6.5 to 10.8 years (mean 8.2, SD 1.1). Quantitative muscle MRI included the mean fat fraction using a 2-point Dixon technique, and transverse relaxation time (T2) measurements...
November 21, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29165163/the-potential-protective-effect-of-commelina-nudiflora-l-against-carbon-tetrachloride-ccl4-induced-hepatotoxicity-in-rats-mediated-by-suppression-of-oxidative-stress-and-inflammation
#18
Muhammad Dawood Shah, Urban J A D'Souza, Mohammad Iqbal
BACKGROUND: This study aims to assess the hepatoprotective potential of Commelina nudiflora against CCl4-induced hepatic injury in rats. METHOD: Antioxidant activities were determined. Phytochemical analysis was performed by gas chromatography mass spectrometry (GCMS). In the in vivo study, Sprague Dawley rats were pretreated with C. nudiflora (150, 300, and 450 mg kg body weight (b.wt.)) once daily for 14 days followed by two doses of CCl4 (1 ml/kg b.wt.). After 2 weeks, the rats were sacrificed and hepatoprotective analysis was performed...
September 11, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29154265/analysis-of-correlation-between-degeneration-of-lower-lumbar-paraspinal-muscles-and-spinopelvic-alignment-in-patients-with-osteoporotic-vertebral-compression-fracture
#19
Qiguang Li, Jianmin Sun, Xingang Cui, Zhensong Jiang, Tao Li
BACKGROUND: A few studies have pointed that trunk extensors may affect the spinopelvic alignment; however, little is known about the exact association between degeneration of lower lumbar paraspinal muscles and spinopelvic parameters. OBJECTIVE: The study aimed to analyze the relationship between degeneration of lower lumbar paraspinal muscles and spinopelvic alignment in patients with osteoporotic vertebral compression fracture (OVCF). METHODS: Thirty-nine OVCF patients were involved in this study...
November 6, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29153456/association-of-mortality-with-ocular-diseases-and-visual-impairment-in-the-age-related-eye-disease-study-2-age-related-eye-disease-study-2-report-number-13
#20
Chandana Papudesu, Traci E Clemons, Elvira Agrón, Emily Y Chew
PURPOSE: To evaluate the association of mortality with visual acuity (VA) impairment, age-related macular degeneration (AMD), and cataract surgery. DESIGN: Cohort study. PARTICIPANTS: Participants with at least intermediate AMD enrolled in a randomized controlled clinical trial of lutein/zeaxanthin and/or omega-3 fatty acids, the Age-Related Eye Disease Study 2 (AREDS2), for treatment of AMD and cataract. METHODS: Baseline and annual eye examinations included best-corrected visual acuity (BCVA) assessments, slit-lamp examinations, and stereoscopic fundus photographs that were centrally graded for development of late AMD (central geographic atrophy or neovascular AMD) or pseudophakia...
November 16, 2017: Ophthalmology
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