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https://www.readbyqxmd.com/read/29154265/analysis-of-correlation-between-degeneration-of-lower-lumbar-paraspinal-muscles-and-spinopelvic-alignment-in-patients-with-osteoporotic-vertebral-compression-fracture
#1
Qiguang Li, Jianmin Sun, Xingang Cui, Zhensong Jiang, Tao Li
BACKGROUND: A few studies have pointed that trunk extensors may affect the spinopelvic alignment; however, little is known about the exact association between degeneration of lower lumbar paraspinal muscles and spinopelvic parameters. OBJECTIVE: The study aimed to analyze the relationship between degeneration of lower lumbar paraspinal muscles and spinopelvic alignment in patients with osteoporotic vertebral compression fracture (OVCF). METHODS: Thirty-nine OVCF patients were involved in this study...
November 6, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29153456/association-of-mortality-with-ocular-diseases-and-visual-impairment-in-the-age-related-eye-disease-study-2-age-related-eye-disease-study-2-report-number-13
#2
Chandana Papudesu, Traci E Clemons, Elvira Agrón, Emily Y Chew
PURPOSE: To evaluate the association of mortality with visual acuity (VA) impairment, age-related macular degeneration (AMD), and cataract surgery. DESIGN: Cohort study. PARTICIPANTS: Participants with at least intermediate AMD enrolled in a randomized controlled clinical trial of lutein/zeaxanthin and/or omega-3 fatty acids, the Age-Related Eye Disease Study 2 (AREDS2), for treatment of AMD and cataract. METHODS: Baseline and annual eye examinations included best-corrected visual acuity (BCVA) assessments, slit-lamp examinations, and stereoscopic fundus photographs that were centrally graded for development of late AMD (central geographic atrophy or neovascular AMD) or pseudophakia...
November 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29150503/carbon-amendments-alter-microbial-community-structure-and-net-mercury-methylation-potential-in-sediments
#3
Geoff A Christensen, Anil C Somenahally, James G Moberly, Carrie M Miller, Andrew J King, Cynthia C Gilmour, Steven D Brown, Mircea Podar, Craig C Brandt, Scott C Brooks, Anthony V Palumbo, Judy D Wall, Dwayne A Elias
Neurotoxic methylmercury (MeHg) is produced by anaerobic Bacteria and Archaea possessing the genes hgcAB, but it is unknown how organic substrate and electron acceptor availability impact the distribution and abundance of these organisms. We evaluated the impact of organic substrate amendments on mercury (Hg) methylation rates, microbial community structure, and the distribution of hgcAB(+) microbes with sediments. Sediment slurries were amended with short-chain fatty acids, alcohols, or a polysaccharide. Minimal increases in MeHg were observed following lactate, ethanol and methanol amendments while a significant decrease (∼70%) was observed with cellobiose incubations...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29136253/fatty-degeneration-of-the-rotator-cuff-reflects-shoulder-strength-deficits-in-patients-with-rotator-cuff-tears
#4
Jong Pil Yoon, Jae Wook Jung, Chang Hwa Lee, Young Gun Kim, Seok Won Chung, Joon Yub Kim, Hyun Joo Lee, Jee Wook Yoon, Hoseok Lee
Fatty degeneration is an important clinical factor in patients with rotator cuff tears. Goutallier grade, occupation ratio, and tangent sign help identify fatty degeneration; however, little is known about how closely these measurement techniques correlate with actual muscle strength deficits. The authors evaluated each method's ability to determine the correlation between fatty degeneration and muscle strength deficits. The authors included 203 patients who underwent full-thickness rotator cuff repair (mean age, 61...
November 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/29117256/mri-defined-paraspinal-muscle-morphology-in-japanese-population-the-wakayama-spine-study
#5
Takahide Sasaki, Noriko Yoshimura, Hiroshi Hashizume, Hiroshi Yamada, Hiroyuki Oka, Ko Matsudaira, Hiroki Iwahashi, Kazunori Shinto, Yuyu Ishimoto, Keiji Nagata, Masatoshi Teraguchi, Ryohei Kagotani, Shigeyuki Muraki, Toru Akune, Sakae Tanaka, Hiroshi Kawaguchi, Kozo Nakamura, Akihito Minamide, Yukihiro Nakagawa, Munehito Yoshida
OBJECTIVE: This study aimed to establish sex- and age-dependent distributions of the cross sectional area and fatty infiltration ratio of paraspinal muscles, and to examine the correlation between paraspinal muscle degeneration and low back pain in the Japanese population. METHODS: In this cross-sectional study, data from 796 participants (241 men, 555 women; mean age, 63.5 years) were analyzed. The measurement of the cross sectional area and fatty infiltration ratio of the erector spinae and multifidus from the level of T12/L1 to L4/5 and psoas major at the level of T12/L1 was performed using axial T2-weighted magnetic resonance imaging...
2017: PloS One
https://www.readbyqxmd.com/read/29113457/the-occurrence-of-deep-pectoral-myopathy-in-broilers-and-associated-changes-in-breast-meat-quality
#6
S Yalcin, S Ozkan, M C Acar, O Meral
1. Two experiments were conducted to determine the effect of slaughter weight on the incidence and intensity of deep pectoral myopathy (DPM) of M. pectoralis minor (p. minor muscle) in commercial conditions in Turkey and to evaluate the impact of DPM on meat quality traits of pectoralis major (p. major) muscle in broilers. 2. In Experiment 1, a total of 116 250 carcasses from 59 Ross-308 broiler flocks, classified according to slaughter weight as 2.0-2.2, 2.2-2.4, 2.4-2.6 and >2.6 kg, were evaluated for occurrence of DPM...
November 8, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29104115/lowered-ipla2%C3%AE-activity-causes-increased-mitochondrial-lipid-peroxidation-and-mitochondrial-dysfunction-in-a-rotenone-induced-model-of-parkinson-s-disease
#7
Honglu Chao, Yinlong Liu, Xian Fu, Xiupeng Xu, Zhongyuan Bao, Chao Lin, Zheng Li, Yan Liu, Xiaoming Wang, Yongping You, Ning Liu, Jing Ji
iPLA2γ, calcium-independent phospholipase A2γ, discerningly hydrolyses glycerophospholipids to liberate free fatty acids. iPLA2γ-deficiency has been associated with abnormal mitochondrial function. More importantly, the iPLA2 family is causative proteins in mitochondrial neurodegenerative disorders such as parkinsonian disorders. However, the mechanisms by which iPLA2γ affects Parkinson's disease (PD) remain unknown. Mitochondrion stress has a key part in rotenone-induced dopaminergic neuronal degeneration...
November 2, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29103059/fatty-degeneration-of-the-deltoid-muscle-associated-with-displaced-proximal-humerus-fractures
#8
M Panzica, J Brandes, U Schmiddem, A Karch, N Hawi, C Krettek, R Meller
INTRODUCTION: The use of reverse shoulder arthroplasty (RSA) has increased dramatically over the last two decades, with many surgeons now indicating RSA for the acute management of displaced proximal humerus fractures (PHF) in the elderly. RSA relies on adequate deltoid muscle function to obtain a good outcome, yet no literature to date exists which discusses preoperative assessment of deltoid structure prior to RSA. The purpose of this study was to assess for preoperative fatty deltoid-degeneration in patients with displaced PHF...
October 23, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29102916/the-effect-of-insulin-loaded-trimethylchitosan-nanoparticles-on-rats-with-diabetes-type-i
#9
Mohammad Jamshidi, Nasrin Ziamajidi, Iraj Khodadadi, Arash Dehghan, Giti Kalantarian, Roghayeh Abbasalipourkabir
OBJECTIVE: The aim of this study was to explore the efficacy of insulin-loaded trimethylchitosan nanoparticles on certain destructive effects of diabetes type one. MATERIALS AND METHODS: Twenty-five male Wistar rats were randomly divided into three control groups (n=5) and two treatment groups (n=5). The control groups included normal diabetic rats without treatment and diabetic rats treated with the nanoparticles. The treatment groups included diabetic rats treated with the insulin-loaded trimethylchitosan nanoparticles and the diabetic rats treated with trade insulin...
November 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29099085/eburicoic-acid-a-triterpenoid-compound-from-antrodia-camphorata-displays-antidiabetic-and-antihyperlipidemic-effects-in-palmitate-treated-c2c12-myotubes-and-in-high-fat-diet-fed-mice
#10
Cheng-Hsiu Lin, Yueh-Hsiung Kuo, Chun-Ching Shih
This study was designed to investigate the antidiabetic and antihyperlipidemic effects and mechanisms of eburicoic acid (TRR); one component of Antrodia camphorata in vitro and in an animal model for 14 weeks. Expression levels of membrane glucose transporter type 4 (GLUT4); phospho-5'-adenosine monophosphate-activated protein kinase (AMPK)/total AMPK; and phospho-Akt/total-Akt in insulin-resistant C2C12 myotube cells were significantly decreased by palmitate; and such decrease was prevented and restored by TRR at different concentrations...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29098642/oxidation-induced-increase-in-photoreactivity-of-bovine-retinal-lipid-extract
#11
A Koscielniak, M Serafin, M Duda, T Oles, A Zadlo, A Broniec, O Berdeaux, S Gregoire, L Bretillon, T Sarna, A Pawlak
The mammalian retina contains a high level of polyunsaturated fatty acids, including docosahexaenoic acid (22:6) (DHA), which are highly susceptible to oxidation. It has been shown that one of the products of DHA oxidation-carboxyethylpyrrole (CEP), generated in situ, causes modifications of retinal proteins and induces inflammation response in the outer retina. These contributing factors may play a role in the development of age-related macular degeneration (AMD). It is also possible that some of the lipid oxidation products are photoreactive, and upon irradiation with blue light may generate reactive oxygen species...
November 2, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29089890/long-chain-omega-3-fatty-acids-supplementation-accelerates-nerve-regeneration-and-prevents-neuropathic-pain-behavior-in-mice
#12
Rafaela V Silva, Julia T Oliveira, Bruna L R Santos, Fabiana C Dias, Ana M B Martinez, Cleverton K F Lima, Ana L P Miranda
Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allodynia and hyperalgesia. We tested the preventive effect of an EPA/DHA-concentrate fish oil (CFO) on NP development and regenerative features. Swiss mice received daily oral treatment with CFO 4...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29059709/microglial-dysfunction-as-a-key-pathological-change-in-adrenomyeloneuropathy
#13
Yi Gong, Nikhil Sasidharan, Fiza Laheji, Matthew Frosch, Patricia Musolino, Rudy Tanzi, Doo Yeon Kim, Alessandra Biffi, Joseph El Khoury, Florian Eichler
OBJECTIVE: Mutations in ABCD1 cause the neurodegenerative disease, adrenoleukodystrophy, which manifests as the spinal cord axonopathy adrenomyeloneuropathy (AMN) in nearly all males surviving into adulthood. Microglial dysfunction has long been implicated in pathogenesis of brain disease, but its role in the spinal cord is unclear. METHODS: We assessed spinal cord microglia in humans and mice with AMN and investigated the role of ABCD1 in microglial activity toward neuronal phagocytosis in cell culture...
October 23, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29050895/minimal-invasive-lumbar-spine-revision-surgery-at-distance-from-the-dura-and-postsurgical-scar-tissue-extraforaminal-lumbar-interbody-fusion-elif
#14
Arthur R Kurzbuch, Didier Recoules-Arche
Lumbar spine revision surgery is considered as challenging and related to longer operation time and complications because of the loss of anatomical landmarks and the formation of postoperative epidural fibrosis. Minimal invasive lumbar spinal surgery techniques have been refined over the last 5 years but the reexposure of the dura, the formation of postsurgical scar tissue and related dural tears remain a source of complications. For lumbar spinal revision surgery we advocate the minimal invasive Extraforaminal Lumbar Interbody Fusion (ELIF) technique...
October 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29043378/-neurogenic-myopathies-and-imaging-of-muscle-denervation
#15
REVIEW
M Wolf, C Wolf, M-A Weber
CLINICAL ISSUE: Neurogenic myopathies are primary diseases of the nervous system, which secondarily result in denervation of the target musculature. The spectrum of potential causes is manifold ranging from acute traumatic injuries and chronic compression to neurodegenerative, inflammatory, metabolic and neoplastic processes. STANDARD DIAGNOSTIC METHODS: The medical history, clinical neurological examination, and electrophysiological tests including electromyography and nerve conduction studies are crucial in diagnosing neuropathic myopathies...
October 17, 2017: Der Radiologe
https://www.readbyqxmd.com/read/29037308/topographic-mri-evaluation-of-the-sacroiliac-joints-in-patients-with-axial-spondyloarthritis
#16
Laís Uyeda Aivazoglou, Orlando Rondan Zotti, Marcelo de Medeiros Pinheiro, Moacir Ribeiro de Castro Junior, Andrea Puchnick, Artur da Rocha Corrêa Fernandes, Eloy de Ávila Fernandes
OBJECTIVE: To evaluate the imaging features of spondyloarthritis in magnetic resonance imaging (MRI) of the sacroiliac (SI) joint and topography (in thirds) and affected margin, considering that this issue is rarely addressed in the literature. METHODS: A cross-sectional study evaluating MRI (1.5T) of SI in 16 patients with axial spondyloarthritis, for the presence of acute (subchondral bone edema, enthesitis, synovitis and capsulitis) and chronic (erosions, subchondral bone sclerosis, bony bridges, and fatty infiltration) changes, performed by two blinded radiologists...
September 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29030883/polyunsaturated-fatty-acids-influence-inflammatory-markers-in-a-cellular-model-for-canine-osteoarthritis
#17
N Adler, A Schoeniger, H Fuhrmann
Although it is well recognized that dietary supplementation with fish oil improves clinical symptoms in dogs suffering from osteoarthritis, the molecular basis for the dietary benefit is not yet completely resolved in dogs. This study was designed to further clarify how polyunsaturated fatty acids (PUFA) affect key factors of cartilage degeneration in a canine cell culture system mimicking osteoarthritis. Canine chondrocytes were incubated either without or with 10 μm of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA) or 3...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29021975/effect-of-melatonin-versus-vitamin-d-as-antioxidant-and-hepatoprotective-agents-in-stz-induced-diabetic-rats
#18
Abdulmonim A Alqasim, Essam Eldin M Noureldin, Sami H Hammadi, Ghada E Esheba
BACKGROUND: Diabetes mellitus (DM) is a serious chronic disease, with multiple complications including hepatopathy associated with imbalance of the oxidative status. The purpose of this study is to observe possible protective effects of vitamin-D and melatonin on glucose profile, antioxidant-oxidant status, lipid peroxidation, and histopathological protection of the liver in streptozotocin-induced diabetic rats. METHODS: Eighty three male albino rats were divided into nine groups as follows: G1 (n = 10) Normal control rats; G2 (n = 8) were normal rats treated with melatonin only; G3 (n = 10) were normal rats treated with vitamin D only; G4 (n = 9) were diabetic rats, which received no medications; G5 (n = 8) were diabetic rat treated with insulin only; G6 (n = 10) were diabetic rats treated with melatonin only; G7 (n = 9) were diabetic rats treated with melatonin and insulin; G8 (n = 9) were diabetic rats treated with vitamin D only; G9 (n = 10) were diabetic rats treated with vitamin D and insulin...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29021101/comparison-between-the-patients-with-surgery-and-without-surgery-after-recommendation-of-surgical-repair-for-symptomatic-rotator-cuff-tear
#19
Jae Chul Yoo, Tae Kang Lim, Dong Hyok Kim, Kyoung-Hwan Koh
PURPOSE: Symptomatic full-thickness rotator cuff (RC) tears are often recommended for surgical repairs. However, some patients decide not to have surgery. The aim of this study was to see if there was any difference in preoperative variables between the two groups. METHODS: 137 consecutive patients recommended for surgery due to symptomatic full-thickness RC tear were evaluated. At mean 58.1 months after surgery-recommendation, the patients were asked whether they had surgery and their clinical outcome was assessed...
October 8, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28986620/-imaging-of-primary-muscular-diseases-what-do-neurologists-expect-from-radiologists
#20
REVIEW
M P Wattjes, A Fischmann, D Fischer
Imaging, in particular magnetic resonance imaging (MRI), has in recent years increasingly become a crucial tool for the diagnostics of inherited and acquired muscular diseases. The aim of imaging in neuromuscular disorders goes beyond the detection and quantification of degenerative muscular changes, such as fatty degeneration and includes recognition of very early signs of muscular pathologies presenting as muscular edema. Therefore, imaging is a valuable diagnostic method to support the clinical diagnosis and to narrow down the differential diagnoses, leading to specific additional diagnostic tests in order to establish the correct diagnosis...
October 6, 2017: Der Radiologe
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