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https://www.readbyqxmd.com/read/28804588/first-reported-case-of-arrhythmogenic-right-ventricular-cardiomyopathy-in-oman
#1
Hatim Al Lawati, Humoud Al Dhuhli
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic disorder characterized by fatty degeneration of the right ventricular myocardium with variable involvement of the left ventricle. The condition is associated with exercise-mediated ventricular tachycardia and is one of the recognized causes of sudden cardiac death in the young and in athletes. Here, we report the first confirmed case of ARVC in Oman and present its electrocardiographic, echocardiographic features, and radiological findings on gated, contrast-enhanced cardiac computed tomography...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28801523/dietary-modulation-of-oxylipins-in-cardiovascular-disease-and-aging
#2
Stephanie P B Caligiuri, Mihir Parikh, Aleksandra Stamenkovic, Grant N Pierce, Harold M Aukema
Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated fatty acids and are involved in processes such as inflammation, immunity, pain, vascular tone and coagulation. As a result, oxylipins are implicated in many conditions characterized by these processes including cardiovascular disease and aging. The best characterized oxylipins in relation to cardiovascular disease are derived from the ω-6 fatty acid arachidonic acid. These oxylipins generally increase inflammation, hypertension and platelet aggregation, although not universally...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28795301/organotypic-cultures-from-the-adult-cns-a-novel-model-to-study-demyelination-and-remyelination-ex-vivo
#3
Glaiza A Tan, Kendra L Furber, Merlin P Thangaraj, LaRhonda Sobchishin, J Ronald Doucette, Adil J Nazarali
Experimental models of multiple sclerosis (MS) have significantly advanced our understanding of pathophysiology and therapeutic interventions. Although in vivo rodent models are considered to most closely represent the complex cellular and molecular disease states of the human central nervous system (CNS), these can be costly to maintain and require long timelines. Organotypic slice cultures maintain the cytotypic organization observed in the intact CNS, yet provide many of the experimental advantages of in vitro cell culture models...
August 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28763559/adiponectin-mediates-dietary-omega-3-long-chain-polyunsaturated-fatty-acid-protection-against-choroidal-neovascularization-in-mice
#4
Zhongjie Fu, Raffael Liegl, Zhongxiao Wang, Yan Gong, Chi-Hsiu Liu, Ye Sun, Bertan Cakir, Samuel B Burnim, Steven S Meng, Chatarina Löfqvist, John Paul SanGiovanni, Ann Hellström, Lois E H Smith
Purpose: Neovascular age-related macular degeneration (AMD) is a major cause of legal blindness in the elderly. Diets with omega3-long-chain-polyunsaturated-fatty-acid (ω3-LCPUFA) correlate with a decreased risk of AMD. Dietary ω3-LCPUFA versus ω6-LCPUFA inhibits mouse ocular neovascularization, but the underlying mechanism needs further exploration. The aim of this study was to investigate if adiponectin (APN) mediated ω3-LCPUFA suppression of neovessels in AMD. Methods: The mouse laser-induced choroidal neovascularization (CNV) model was used to mimic some of the inflammatory aspect of AMD...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28755303/-degeneration-of-the-posterior-tibial-tendon-established-and-new-concepts
#5
REVIEW
Markus Walther
BACKGROUND: The most common cause of degeneration of the posterior tibial tendon is a congenital valgus deformity of the calcaneus. Other associated pathologies are forefoot supination, forefoot abduction and shortening of the gastrocnemius muscle. DIAGNOSTICS: Loaded x‑rays of the foot in three planes as well as the hindfoot alignment view enable evaluation of the axis of the foot under static loading conditions. The posterior tibial tendon can be imaged with ultrasound and magnetic resonance imaging (MRI)...
July 28, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28751808/relationship-between-hyposalivation-and-oxidative-stress-in-aging-mice
#6
Yoshitaka Yamauchi, Tomonori Matsuno, Kazuhiko Omata, Tazuko Satoh
The increase in oxidative stress that accompanies aging has been implicated in the abnormal advance of aging and in the onset of various systemic diseases. However, the details of what effects the increase in oxidative stress that accompanies aging has on saliva secretion are not known. In this study, naturally aging mice were used to examine the stimulated whole saliva flow rate, saliva and serum oxidative stress, antioxidant level, submandibular gland H-E staining, and immunofluorescence staining to investigate the effect of aging on the volume of saliva secretion and the relationship with oxidative stress, as well as the effect of aging on the structure of salivary gland tissue...
July 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28751741/soil-microbial-community-structure-and-catabolic-activity-are-significantly-degenerated-in-successive-rotations-of-chinese-fir-plantations
#7
Zeyan Wu, Jianjuan Li, Jie Zheng, Jinfu Liu, Shuying Liu, Wenxiong Lin, Chengzhen Wu
This study examined the hypotheses that soil microbial community composition and catabolic activity would significantly degenerated by consecutive monoculture in Chinese fir plantations. The phospholipid fatty acids (PLFA) and community level physiological profiles (CLPP) methods were used to assess the variations of soil microbial community among the first rotation Chinese fir plantation (FCP), the second rotation plantation (SCP) and the third rotation plantation (TCP). The total content of PLFA biomarkers was highest in FCP, followed by SCP, and TCP was the least detected...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28745679/-low-back-pain-and-modic-changes
#8
E L Sokov, L E Kornilova, A I Nesterov
Modic changes (MCh) are pathological changes in the bone marrow and the endplates of adjacent vertebrae characterized by bone marrow edema, fatty degeneration or osteosclerosis that are revealed by high-power field magnetic resonance imaging (MRI). The dominant disease pattern is a persistent back pain syndrome with varying intensity. It leads to difficulties in the interpretation of clinical data, evaluation of MRI data and treatment. The article presents a modern conception of the pathogenesis, classification, clinical implications and treatment of MCh based on national and foreign sources as well and the author's view on the osteogenic mechanism of the pathogenesis and treatment of MCh using intraosseous blockades...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28741426/influence-of-different-irradiation-protocols-on-vascularization-and-bone-formation-parameters-in-rat-femora
#9
Ulrike Rottensteiner-Brandl, Luitpold Distel, Martin Stumpf, Tobias Fey, Katrin Köhn, Ulf Bertram, Lara F Lingens, Peter Greil, Raymund E Horch, Andreas Arkudas
INTRODUCTION: Aim of the present study was the establishment of an efficient and reproducible model for irradiation of rat femora as a model for impaired osteogenesis and angiogenesis. MATERIALS AND METHODS: Four different irradiation protocols were compared: single irradiation of the left femur with 20 Gy and explantation after 4 or 8 weeks (group A, B); three irradiation fractions at 3-4 days intervals with 10 Gy and explantation after 4 or 8 weeks (group C, D)...
July 25, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28738845/lutein-and-zeaxanthin-isomers-modulates-lipid-metabolism-and-the-inflammatory-state-of-retina-in-obesity-induced-high-fat-diet-rodent-model
#10
Mehmet Tuzcu, Cemal Orhan, Omer Ersin Muz, Nurhan Sahin, Vijaya Juturu, Kazım Sahin
BACKGROUND: Several studies associated high-fat intakes with a high incidence of age-related macular degeneration (AMD). Lutein and Zeaxanthin isomers (L/Zi) may counteract reactive oxygen species produced by oxidative stress. The present study was conducted to determine the possible effects of L/Zi administration on lipid profile, protein genes associated with oxidative stress and inflammation pathways in the obesity induced by a high-fat diet (HFD) in rodents. METHODS: Twenty-eight male Wistar rats were allocated into four groups as follows: (i) Control, (ii) Control + L/Zi, (iii) High Fat Diet (HFD), and (iv) HFD+ L/Z...
July 24, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28733207/uplc-q-tof-ms-based-urine-and-plasma-metabonomics-study-on-the-ameliorative-effects-of-aspirin-eugenol-ester-in-hyperlipidemia-rats
#11
Ning Ma, Xi-Wang Liu, Xiao-Jun Kong, Zhe Qin, Shi-Hong Li, Zeng-Hua Jiao, Peng-Cheng Dong, Ya-Jun Yang, Jian-Yong Li
The main objective of this study was to investigate the ameliorative effects of aspirin eugenol ester (AEE) in hyperlipidemic rat. After five-week oral administration of AEE in high fat diet (HFD)-induced hyperlipidemic rats, the impact of AEE on plasma and urine metabonomics was investigated to explore the underlying mechanism by UPLC-Q-TOF/MS analysis. Blood lipid levels and histopathological changes of liver, stomach and duodenum were also evaluated after AEE treatment. Without obvious gastrointestinal (GI) side effects, AEE significantly relieved fatty degeneration of liver and reduced triglyceride (TG), low density lipoprotein (LDL) and total cholesterol (TCH) (P<0...
July 18, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28709001/ciliary-hedgehog-signaling-restricts-injury-induced-adipogenesis
#12
Daniel Kopinke, Elle C Roberson, Jeremy F Reiter
Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) proliferated and gave rise to adipocytes. These FAPs dynamically produced primary cilia, structures that transduce intercellular cues such as Hedgehog (Hh) signals. Genetically removing cilia from FAPs inhibited intramuscular adipogenesis, both after injury and in a mouse model of Duchenne muscular dystrophy. Blocking FAP ciliation also enhanced myofiber regeneration after injury and reduced myofiber size decline in the muscular dystrophy model...
July 13, 2017: Cell
https://www.readbyqxmd.com/read/28706969/quantitative-analysis-of-immune-cell-subset-infiltration-of-supraspinatus-muscle-after-severe-rotator-cuff-injury
#13
J R Krieger, L E Tellier, M T Ollukaren, J S Temenoff, E A Botchwey
Rotator cuff tears cause muscle degeneration that is characterized by myofiber atrophy, fatty infiltration, and fibrosis and is minimally responsive to current treatment options. The underlying pathogenesis of rotator cuff muscle degeneration remains to be elucidated, and increasing evidence implicates immune cell infiltration as a significant factor. Because immune cells are comprised of highly heterogeneous subpopulations that exert divergent effects on injured tissue, understanding trafficking and accumulation of immune subpopulations may hold the key to more effective therapies...
June 2017: Regenerative Engineering and Translational Medicine
https://www.readbyqxmd.com/read/28706274/elovanoids-are-novel-cell-specific-lipid-mediators-necessary-for-neuroprotective-signaling-for-photoreceptor-cell-integrity
#14
Bokkyoo Jun, Pranab K Mukherjee, Aram Asatryan, Marie-Audrey Kautzmann, Jessica Heap, William C Gordon, Surjyadipta Bhattacharjee, Rong Yang, Nicos A Petasis, Nicolas G Bazan
Docosahexaenoic acid (DHA, 22:6 n-3) is abundant in the retina and is enzymatically converted into pro-homeostatic docosanoids. The DHA- or eicosapentaenoic acid (EPA)-derived 26 carbon fatty acid is a substrate of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long chain (≥C28) polyunsaturated fatty acids including n-3 (VLC-PUFAs,n-3). While ELOVL4 mutations are linked to vision loss and neuronal dysfunctions, the roles of VLC-PUFAs remain unknown. Here we report a novel class of lipid mediators biosynthesized in human retinal pigment epithelial (RPE) cells that are oxygenated derivatives of VLC-PUFAs,n-3; we termed these mediators elovanoids (ELV)...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698963/change-in-fatty-infiltration-of-lumbar-multifidus-erector-spinae-and-psoas-muscles-in-asymptomatic-adults-of-asian-or-caucasian-ethnicities
#15
Rebecca J Crawford, James M Elliott, Thomas Volken
PURPOSE: Fatty infiltration (FI) is a feature of degenerating muscle that predominates in the low lumbar spine, associates with pain, and is confounded by age, spinal degeneration, and curvature. We determined rates for decline of lumbar muscle quality according to ethnicity, muscle, and spinal level in asymptomatic subjects. METHODS: Cross-sectional simulation study assessing aggregated data; 650 Asians aged 20-89 years versus 80 Caucasians aged 20-62 years. Change in lumbar multifidus, erector spinae (ES), and psoas fat content were computed using synthetic data and Monte Carlo simulations...
July 11, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28686624/adverse-effects-of-chronic-exposure-to-nonylphenol-on-non-alcoholic-fatty-liver-disease-in-male-rats
#16
Jie Yu, Xuesong Yang, Ya Luo, Xuefeng Yang, Mengxue Yang, Jin Yang, Jie Zhou, Feng Gao, Liting He, Jie Xu
Endocrine-disrupting chemical (EDC) has been thought to play a role in non-alcoholic fatty liver disease (NAFLD). However, the toxic effects of Nonylphenol (NP), an EDC, on non-alcoholic fatty liver disease have never been elaborated. This study aimed to investigate whether exposure to NP could induce NAFDL, a promoting effect of high-sucrose-high-fat diet (HSHFD) on the adverse effects caused by NP was evaluated. Fourth eight male rats were assigned to four groups and each group was treated with a specific testing sample: normal-diet (ND) control group (C-ND); normal diet plus NP (180mg/kg/day) group (NP-ND); high-sucrose-high-fat-diet control group (C-HSHFD); HSHFD plus NP (180mg/kg/day) group (NP-HSHFD)...
2017: PloS One
https://www.readbyqxmd.com/read/28685531/impact-of-rantes-from-jawbone-on-chronic-fatigue-syndrome
#17
RANDOMIZED CONTROLLED TRIAL
J Lechner, K Huesker, V Von Baehr
This study elucidates the question of whether chronic inflammation in the jawbone contributes to the development of Chronic Fatigue Syndrome (CFS). Fatty degenerative osteonecrosis in jawbone (FDOJ) may contribute to CFS by induction of inflammatory mediators. We examined seven cytokines by multiplex analysis in jawbone samples from two groups of patients. In order to clarify neurological interrelations, specimens from 21 CFS patients were analyzed from areas of previous surgery in the retromolar wisdom tooth area...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28672005/fatty-acid-transport-protein-1-regulates-retinoid-metabolism-and-photoreceptor-development-in-mouse-retina
#18
Aurélie Cubizolle, Laurent Guillou, Bertrand Mollereau, Christian P Hamel, Philippe Brabet
In retinal pigment epithelium (RPE), RPE65 catalyzes the isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol in the visual cycle and controls the rhodopsin regeneration rate. However, the mechanisms by which these processes are regulated are still unclear. Fatty Acid Transport Protein 1 (FATP1) is involved in fatty acid uptake and lipid metabolism in a variety of cell types. FATP1 co-localizes with RPE65 in RPE and inhibits its isomerase activity in vitro. Here, we further investigated the role of FATP1 in the visual cycle using transgenic mice that overexpress human FATP1 specifically in the RPE (hFATP1TG mice)...
2017: PloS One
https://www.readbyqxmd.com/read/28670164/texture-analysis-of-torn-rotator-cuff-on-preoperative-magnetic-resonance-arthrography-as-a-predictor-of-postoperative-tendon-status
#19
Yeonah Kang, Guen Young Lee, Joon Woo Lee, Eugene Lee, Bohyoung Kim, Su Jin Kim, Joong Mo Ahn, Heung Sik Kang
OBJECTIVE: To evaluate texture data of the torn supraspinatus tendon (SST) on preoperative T2-weighted magnetic resonance arthrography (MRA) using the gray-level co-occurrence matrix (GLCM) for prediction of post-operative tendon state. MATERIALS AND METHODS: Fifty patients who underwent arthroscopic rotator cuff repair for full-thickness tears of the SST were included in this retrospective study. Based on 1-year follow-up, magnetic resonance imaging showed that 30 patients had intact SSTs, and 20 had rotator cuff retears...
July 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28661723/differences-of-rna-expression-in-the-tendon-according-to-anatomic-outcomes-in-rotator-cuff-repair
#20
Jin-Ok Ahn, Jin-Young Chung, Do Hoon Kim, Wooseok Im, Sae Hoon Kim
BACKGROUND: Despite increased understanding of the pathophysiology of rotator cuff tears and the evolution of rotator cuff repair, healing failure remains a substantial problem. The critical roles played by biological factors have been emphasized, but little is known of the implications of gene expression profile differences at the time of repair. PURPOSE: To document the relationship between the perioperative gene expression of healed and unhealed rotator cuffs by RNA microarray analysis...
June 1, 2017: American Journal of Sports Medicine
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