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Fatty degeneration

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https://www.readbyqxmd.com/read/28926379/tendon-length-calf-muscle-atrophy-and-strength-deficit-after-acute-achilles-tendon-rupture-long-term-follow-up-of-patients-in-a-previous-study
#1
Juuso Heikkinen, Iikka Lantto, Juuso Piilonen, Tapio Flinkkilä, Pasi Ohtonen, Pertti Siira, Vesa Laine, Jaakko Niinimäki, Ari Pajala, Juhana Leppilahti
BACKGROUND: In this prospective study, we used magnetic resonance imaging (MRI) to assess long-term Achilles tendon length, calf muscle volume, and muscle fatty degeneration after surgery for acute Achilles tendon rupture. METHODS: From 1998 to 2001, 60 patients at our center underwent surgery for acute Achilles tendon rupture followed by early functional postoperative rehabilitation. Fifty-five patients were reexamined after a minimum duration of follow-up of 13 years (mean, 14 years), and 52 of them were included in the present study...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28919690/subchronic-toxicity-of-nile-tilapia-with-different-exposure-routes-to-microcystis-aeruginosa-histopathology-liver-functions-and-oxidative-stress-biomarkers
#2
H M R Abdel-Latif, A M Abou Khashaba
BACKGROUND: Toxic cyanobacterial blooms (Microcystis aeruginosa contains microcystins [MCs]) have been reported to induce clinicopathological alterations as well as different oxidative stress in aquatic biota. AIM: Three-week subchronic exposure experiment was carried out on Nile tilapia, to determine their effects on fish behavior, tissues, liver functions, antioxidant enzymes, and lipid peroxidation. MATERIALS AND METHODS: Fish were exposed to four main treatments; orally fed diet plus toxic cells of M...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28919111/promethazine-hydrochloride-inhibits-ectopic-fat-cell-formation-in-skeletal-muscle
#3
Takehiro Kasai, Masashi Nakatani, Naoki Ishiguro, Kinji Ohno, Naoki Yamamoto, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, Akiyoshi Uezumi
Fatty degeneration of skeletal muscle leads to muscle weakness and loss of function. Preventing fatty degeneration in skeletal muscle is important, but no drug has been used clinically. In this study, we performed drug repositioning using human platelet-derived growth factor receptor α (PDGFRα)-positive mesenchymal progenitors that have been proved to be an origin of ectopic adipocytes in skeletal muscle. We found that promethazine hydrochloride (PH) inhibits adipogenesis in a dose-dependent manner without cell toxicity...
September 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28913287/cryptogenic-temporal-hollowing
#4
Ie Hyon Park, Heeyeon Kwon, Sang Wha Kim
Temporal hollowing is a common complication that occurs after coronal approach surgeries. However, temporal hollowing without previous nerve damage or trauma history is rare. Herein, we present a patient with cryptogenic temporal hollowing. A 22-year-old man without any history of craniofacial interventions or trauma presented with temporal hallowing. Magnetic resonance imaging revealed fatty degeneration of the left temporalis muscle. Electromyography and nerve conduction study showed no signs of neurologic abnormalities...
December 2016: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912007/adventitial-adipogenic-degeneration-is-an-unidentified-contributor-to-aortic-wall-weakening-in-the-abdominal-aortic-aneurysm
#5
Stefan A Doderer, Gabor Gäbel, Vivianne B C Kokje, Bernd H Northoff, Lesca M Holdt, Jaap F Hamming, Jan H N Lindeman
OBJECTIVE: The processes driving human abdominal aortic aneurysm (AAA) progression are not fully understood. Although antiinflammatory and proteolytic strategies effectively quench aneurysm progression in preclinical models, so far all clinical interventions failed. These observations hint at an incomplete understanding of the processes involved in AAA progression and rupture. Interestingly, strong clinical and molecular associations exist between popliteal artery aneurysms (PAAs) and AAAs; however, PAAs have an extremely low propensity to rupture...
September 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28911249/transcriptome-analysis-reveals-the-molecular-mechanism-of-hepatic-fat-metabolism-disorder-caused-by-muscovy-duck-reovirus-infection
#6
Quanxi Wang, Mengxi Liu, Lihui Xu, Yijian Wu, Yifan Huang
The aim of this work was to clarify the molecular mechanism underlying the fatty degeneration of livers infected with Muscovy duck reovirus (MDRV), which produces obvious white necrotic foci in the liver. Transcriptome data for MDRV-infected Muscovy duck livers and control livers were sequenced, assembled, and annotated with Illumina® HiSeq 2000. The differentially expressed genes were screened and their functions analysed. We also determined and confirmed the molecular mechanism of the hepatic fat metabolism disorder caused by MDRV infection...
September 15, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28906128/effect-of-preoperative-fatty-degeneration-of-the-rotator-cuff-muscles-on-the-clinical-outcome-of-patients-with-intact-tendons-after-arthroscopic-rotator-cuff-repair-of-large-massive-cuff-tears
#7
Hiroki Ohzono, Masafumi Gotoh, Hidehiro Nakamura, Hirokazu Honda, Yasuhiro Mitsui, Tatsuyuki Kakuma, Takahiro Okawa, Naoto Shiba
BACKGROUND: Fatty degeneration of the rotator cuff muscles is associated not only with postoperative retear but also with postoperative muscle weakness; therefore, fatty changes in the muscles may affect the clinical outcome even in patients with these tears who have intact tendons after arthroscopic rotator cuff repair (ARCR). PURPOSE: To evaluate the effect of fatty infiltration on the clinical outcome in patients with intact tendons after arthroscopic repair of large/massive cuff tears...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28904295/multidirectional-analyses-of-hepatic-chronotoxicity-induced-by-cadmium-in-mice
#8
Nobuhiko Miura, Hiroki Yoshioka, Atsushige Ashimori, Katsumi Ohtani, Tatsuya Hasegawa, Gi-Wook Hwang, Masayuki Ikeda, Tsunemasa Nonogaki
The expression levels or activities of biological defense factors can fluctuate daily following biological rhythms. We have focused on the relationship between injection timing and the degree of toxicity of cadmium (Cd) to promote the concept of "chronotoxicology," which introduces chronobiology to the field of toxicology. Our previous studies have clearly indicated that Cd may be subject to chronotoxicity. In this report, to confirm the character of the Cd-induced chronotoxicity, we performed multidirectional examinations...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28898884/effects-of-mucuna-pruriens-on-free-fatty-acid-levels-and-histopathological-changes-in-the-brains-of-rats-fed-a-high-fructose-diet
#9
Bekir Akgun, Aysel Sarı, Sait Ozturk, Fatih Serhat Erol, Ibrahim Hanifi Ozercan, Ramazan Ulu
OBJECTIVE: To investigate free fatty acid levels and histopathologic changes in the brain of rats fed a high fructose diet and to evaluate the effects of Mucuna pruriens, known to have antidiabetic activity, on these changes. MATERIALS AND METHODS: The study comprised of 28 mature female Wistar rats. The rats were divided into four groups, each included 7 rats. Group 1: control; Group 2: fed a high fructose diet (HFrD), Group 3: fed normal rat chow and Mucuna pruriens, and Group 4: fed a high fructose diet and Mucuna pruriens for 6 weeks...
September 11, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28869071/role-of-transplanted-bone-marrow-cells-in-development-of-rotator-cuff-muscle-fatty-degeneration-in-mice
#10
Lawrence V Klomps, Naseem Zomorodi, H Mike Kim
BACKGROUND: Rotator cuff muscle fatty degeneration after a chronic tendon tear is an irreversible pathologic change associated with poor clinical outcomes of tendon repair, and its exact pathogenesis remains unknown. We sought to investigate the role of transplanted bone marrow cells in the development of fatty degeneration, specifically in adipocyte accumulation, using a mouse model. METHODS: Fourteen mice were divided into 2 bone marrow chimeric animal groups: bone marrow transplantation (BMT) group and reverse BMT group...
August 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28856520/asiatic-acid-ameliorates-doxorubicin-induced-cardiac-and-hepato-renal-toxicities-with-nrf2-transcriptional-factor-activation-in-rats
#11
Sarika M Kamble, Chandragouda R Patil
Asiatic acid (AA), a pentacyclic triterpenoid, is a key phytoconstituent of Centella asiatica. AA is a patented as a cytotoxic substance, and it exerts cytotoxicity against Hep3B, Hela and MCF-7 cell lines. However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert cytoprotective effects. In this study, we investigated the effects of AA on the doxorubicin (DXR)-induced organ toxicities and expression of the Nrf2. DXR toxicity was induced by a single intravenous injection of 65...
August 30, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28845212/increased-circulating-levels-of-interleukin-6-induce-perturbation-in-redox-regulated-signaling-cascades-in-muscle-of-dystrophic-mice
#12
Laura Pelosi, Laura Forcina, Carmine Nicoletti, Bianca Maria Scicchitano, Antonio Musarò
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein. The pathology of dystrophic muscle includes degeneration, necrosis with inflammatory cell invasion, regeneration, and fibrous and fatty changes. Nevertheless, the mechanisms by which the absence of dystrophin leads to muscle degeneration remain to be fully elucidated. An imbalance between oxidant and antioxidant systems has been proposed as a secondary effect of DMD...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28844908/differential-regulation-of-the-duplicated-fabp7-fabp10-and-fabp11-genes-of-zebrafish-by-peroxisome-proliferator-activated-receptors
#13
Robert B Laprairie, Eileen M Denovan-Wright, Jonathan M Wright
In the duplication-degeneration-complementation model, duplicated gene-pairs undergo nonfunctionalization (loss from the genome), subfunctionalization (the functions of the ancestral gene are sub-divided between duplicate genes), or neofunctionalization (one of the duplicate genes acquires a new function). These processes occur by loss or gain of regulatory elements in gene promoters. Fatty acid-binding proteins (Fabp) belong to a multigene family composed of orthologous proteins that are highly conserved in sequence and function, but differ in their gene regulation...
November 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28843747/arrhythmogenic-right-ventricular-cardiomyopathy-arvc-in-a-young-female-athlete-at-36-weeks-gestation-a-case-report
#14
Hae Yoon Grace Choung, Monika Vyas, Daniel Jacoby, Brian West
A 26year old east African professional athlete presented to the obstetric clinic for a routine visit at 36 weeks gestation. She had a history of Right Ventricular Outflow Tract - Ventricular Tachycardia (RVOT-VT) with an episode of cardiac arrest in the past, and had been treated with ablation 4 years earlier. Her current visit was uneventful, her pregnancy progressing normally. Following the visit she went to a local restaurant where she suffered a cardiac arrest that was unresponsive to therapy. Chest compressions were continued from the time of her collapse until an emergency caesarian section was performed, delivering a healthy female infant...
July 25, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28840052/predictors-of-memory-in-healthy-aging-polyunsaturated-fatty-acid-balance-and-fornix-white-matter-integrity
#15
Marta K Zamroziewicz, Erick J Paul, Chris E Zwilling, Aron K Barbey
Recent evidence demonstrates that age and disease-related decline in cognition depends not only upon degeneration in brain structure and function, but also on dietary intake and nutritional status. Memory, a potential preclinical marker of Alzheimer's disease, is supported by white matter integrity in the brain and dietary patterns high in omega-3 and omega-6 polyunsaturated fatty acids. However, the extent to which memory is supported by specific omega-3 and omega-6 polyunsaturated fatty acids, and the degree to which this relationship is reliant upon microstructure of particular white matter regions is not known...
July 2017: Aging and Disease
https://www.readbyqxmd.com/read/28839472/docosahexaenoic-acid-inhibits-vascular-smooth-muscle-cell-proliferation-induced-by-glucose-variability
#16
Kaliyaperumal Rani, Nway Y Aung
BACKGROUND: Vascular Smooth Muscle cells (VSMC) enact crucial roles in early vasculogenesis and sustenance of vascular integrity. However, aberrant proliferation of VSMC followed by migration into the blood vessel wall leads to the formation of vascular lesions accounting for the degeneration and remodelling of vascular basement membrane. In diabetes, hyperglycaemia accelerates VSMC proliferation and contributes to the initiation and progression of atherosclerotic lesions. Recently, acute glucose fluctuations have been implicated in the abnormal VSMC proliferation and complications of diabetic atherosclerosis...
2017: Open Biochemistry Journal
https://www.readbyqxmd.com/read/28827971/the-potency-of-red-seaweed-eucheuma-cottonii-extracts-as-hepatoprotector-on-lead-acetate-induced-hepatotoxicity-in-mice
#17
Giftania Wardani, Nuraini Farida, Rina Andayani, Mahmiah Kuntoro, Sri Agus Sudjarwo
BACKGROUND: Lead is one of the most toxic metals, producing severe organ damage in animals and humans. Oxidative stress is reported to play an important role in lead acetate-induced liver injury. AIM: This study was carried out to investigate the role of ethanol extract of Eucheuma cottonii in protecting against lead acetate-induced hepatotoxicity in male mice. MATERIALS AND METHODS: The sample used fifty male mice which were divided into five groups: negative control (mice were given daily with Aquadest); positive control (mice were given daily with lead acetate 20 mg/kg body weight (BW) orally once in a day for 21 days); and the treatment group (mice were given E...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28827737/histological-evaluation-of-diabetic-neurodegeneration-in-the-retina-of-zucker-diabetic-fatty-zdf-rats
#18
Klaudia Szabó, Anna Énzsöly, Bulcsú Dékány, Arnold Szabó, Rozina I Hajdú, Tamás Radovits, Csaba Mátyás, Attila Oláh, Lenke K Laurik, Gábor M Somfai, Béla Merkely, Ágoston Szél, Ákos Lukáts
In diabetes, retinal dysfunctions exist prior to clinically detectable vasculopathy, however the pathology behind these functional deficits is still not fully established. Previously, our group published a detailed study on the retinal histopathology of type 1 diabetic (T1D) rat model, where specific alterations were detected. Although the majority of human diabetic patients have type 2 diabetes (T2D), similar studies on T2D models are practically absent. To fill this gap, we examined Zucker Diabetic Fatty (ZDF) rats - a model for T2D - by immunohistochemistry at the age of 32 weeks...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827330/cytochrome-p450-monooxygenase-lipid-metabolites-are-significant-second-messengers-in-the-resolution-of-choroidal-neovascularization
#19
Eiichi Hasegawa, Saori Inafuku, Lama Mulki, Yoko Okunuki, Ryoji Yanai, Kaylee E Smith, Clifford B Kim, Garrett Klokman, Diane R Bielenberg, Narender Puli, John R Falck, Deeba Husain, Joan W Miller, Matthew L Edin, Darryl C Zeldin, Kin Sing Stephen Lee, Bruce D Hammock, Wolf-Hagen Schunck, Kip M Connor
Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular (wet) form of advanced AMD and leads to significant vision loss. A growing body of evidence supports a strong link between neovascular disease and inflammation. Metabolites of long-chain polyunsaturated fatty acids derived from the cytochrome P450 (CYP) monooxygenase pathway serve as vital second messengers that regulate a number of hormones and growth factors involved in inflammation and vascular function...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28804588/first-reported-case-of-arrhythmogenic-right-ventricular-cardiomyopathy-in-oman
#20
Hatim Al Lawati, Humoud Al Dhuhli
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic disorder characterized by fatty degeneration of the right ventricular myocardium with variable involvement of the left ventricle. The condition is associated with exercise-mediated ventricular tachycardia and is one of the recognized causes of sudden cardiac death in the young and in athletes. Here, we report the first confirmed case of ARVC in Oman and present its electrocardiographic, echocardiographic features, and radiological findings on gated, contrast-enhanced cardiac computed tomography...
July 2017: Oman Medical Journal
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