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https://www.readbyqxmd.com/read/28319602/low-hepatic-tissue-copper-in-pediatric-non-alcoholic-fatty-liver-disease
#1
Michael Mendoza, Shelley Caltharp, Ming Song, Lindsay Collin, Juna V Konomi, Craig J McClain, Miriam B Vos
OBJECTIVE: Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in non-alcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children. METHODS: This was a retrospective study of pediatric patients who had a liver biopsy including a hepatic copper quantitation. The primary outcome compared hepatic copper concentration in NAFLD versus non-NAFLD...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28319431/evaluation-of-the-risk-factors-for-a-rotator-cuff-retear-after-repair-surgery
#2
Yeong Seok Lee, Jeung Yeol Jeong, Chan-Deok Park, Seung Gyoon Kang, Jae Chul Yoo
BACKGROUND: A retear is a significant clinical problem after rotator cuff repair. However, no study has evaluated the retear rate with regard to the extent of footprint coverage. PURPOSE: To evaluate the preoperative and intraoperative factors for a retear after rotator cuff repair, and to confirm the relationship with the extent of footprint coverage. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Data were retrospectively collected from 693 patients who underwent arthroscopic rotator cuff repair between January 2006 and December 2014...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28317417/hepatoprotective-effect-of-stachys-pilifera-ethanol-extract-in-carbon-tetrachloride-induce-hepatotoxicity-in-rats
#3
Esmaeel Panahi Kokhdan, Kyomarth Ahmadi, Heibatollah Sadeghi, Hossein Sadeghi, Fahemeh Dadgary, Nazanin Danaei, Mahmoud Reza Aghamaali
CONTEXT: Stachys pilifera Benth (Lamiaceae) has long been used to treat infectious diseases, respiratory and rheumatoid disorders in Iranian folk medicine. Antitumor and antioxidant activity of the plant have been reported. OBJECTIVE: The study was designed to assess the hepatoprotective activity of ethanol extract of Stachys pilifera in carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. MATERIALS AND METHODS: The rats were randomly divided into six equal groups (n = 7)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28315677/rimonabant-a-selective-cannabinoid1-receptor-antagonist-protects-against-light-induced-retinal-degeneration-in-vitro-and-in-vivo
#4
Tomoyo Imamura, Kazuhiro Tsuruma, Yuki Inoue, Tomohiro Otsuka, Yuta Ohno, Shiho Ogami, Shinsaku Yamane, Masamitsu Shimazawa, Hideaki Hara
The endocannabinoid system is involved in some neurodegenerative diseases such as Alzheimer's disease. An endogenous constellation of proteins related to cannabinoid1 receptor signaling, including free fatty acids, diacylglycerol lipase, and N-acylethanolamine-hydrolyzing acid amidase, are localized in the murine retina. Moreover, the expression levels of endogenous agonists of cannabinoid receptors are changed in the vitreous fluid. However, the role of the endocannabinoid system in the retina, particularly in the light-induced photoreceptor degeneration, remains unknown...
March 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28300160/comparison-of-proteomic-profiles-in-the-zebrafish-retina-during-experimental-degeneration-and-regeneration
#5
Karen Eastlake, Wendy E Heywood, Dhani Tracey-White, Erika Aquino, Emily Bliss, Gerardo R Vasta, Kevin Mills, Peng T Khaw, Mariya Moosajee, G Astrid Limb
Zebrafish spontaneously regenerate the retina after injury. Although the gene expression profile has been extensively studied in this species during regeneration, this does not reflect protein function. To further understand the regenerative process in the zebrafish, we compared the proteomic profile of the retina during injury and upon regeneration. Using two-dimensional difference gel electrophoresis (2D-DIGE) and label-free quantitative proteomics (quadrupole time of flight LC-MS/MS), we analysed the retina of adult longfin wildtype zebrafish at 0, 3 and 18 days after Ouabain injection...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297775/-effect-of-calcium-independent-phospholipase-a-2-inhibitor-in-reducing-hepatocyte-lipoapoptosis-and-improving-insulin-resistance
#6
H B Shi, J F Fu, Y Huang, L R Liu
Objective: To investigate the effect of calcium-independent phospholipase A(2) (iPLA(2)) inhibitor in reducing hepatocyte lipoapoptosis and improving insulin resistance. Methods: A total of 28 male Sprague-Dawley rats were randomly divided into the following three groups: 12 rats in group I (normal control group) were given normal diet for 18 weeks; 8 rats in group II (non-alcoholic fatty liver disease model group) were given high-fat diet for 18 weeks; 8 rats in group III (iPLA(2) inhibitor group) were given high-fat diet for 18 weeks and intraperitoneal injection of the iPLA(2) inhibitor bromoenol lactone 150 μg/kg once every other day since week 15 (14 times of injection in total)...
January 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28288466/quantitative-assessment-of-trunk-muscles-involvement-in-patients-with-myotonic-dystrophy-type-1-using-a-whole-body-muscle-magnetic-resonance-imaging
#7
Donghwi Park, Jin-Sung Park
OBJECTIVE: The aim of this study was to analyze the pattern of trunk muscles involvement through a muscle MRI, in relation to the clinical data of patients diagnosed with myotonic dystrophy type 1 (DM1). MATERIALS AND METHODS: Patients with DM1 who visited the neurology department were enrolled (n = 19). In all patients, the fatty degeneration of the muscle MRI in the lower cervical, upper thoracic, middle thoracic, and lumbosacral spine extensor muscle group and trunk flexor muscle group was evaluated...
March 14, 2017: European Neurology
https://www.readbyqxmd.com/read/28286238/the-role-of-the-progressive-ankylosis-protein-ank-in-adipogenic-osteogenic-fate-decision-of-precursor-cells
#8
Takeshi Minashima, Martin Quirno, You Jin Lee, Thorsten Kirsch
The progressive ankylosis protein (ANK) is a transmembrane protein that transports intracellular pyrophosphate (PPi) to the extracellular milieu. In this study we show increased fatty degeneration of the bone marrow of adult ank/ank mice, which lack a functional ANK protein. In addition, isolated bone marrow stromal cells (BMSCs) isolated from ank/ank mice showed a decreased proliferation rate and osteogenic differentiation potential, and an increased adipogenic differentiation potential compared to BMSCs isolated from wild type (WT) littermates...
March 8, 2017: Bone
https://www.readbyqxmd.com/read/28282504/soleus-atrophy-is-common-after-the-nonsurgical-treatment-of-acute-achilles-tendon-ruptures
#9
Juuso Heikkinen, Iikka Lantto, Tapio Flinkkila, Pasi Ohtonen, Jaakko Niinimaki, Pertti Siira, Vesa Laine, Juhana Leppilahti
BACKGROUND: It remains controversial whether nonsurgical or surgical treatment provides better calf muscle strength recovery after an acute Achilles tendon rupture (ATR). Recent evidence has suggested that surgery might surpass nonsurgical treatment in restoring strength after an ATR. PURPOSE: To assess whether magnetic resonance imaging (MRI) findings could explain calf muscle strength deficits and the difference between nonsurgical and surgical treatments in restoring calf muscle strength...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28271618/plasma-long-chain-omega-3-polyunsaturated-fatty-acids-and-macular-pigment-in-subjects-with-family-history-of-age-related-macular-degeneration-the-limpia-study
#10
Bénédicte M J Merle, Benjamin Buaud, Jean-François Korobelnik, Alain Bron, Marie-Noëlle Delyfer, Marie-Bénédicte Rougier, Hélène Savel, Carole Vaysse, Catherine Creuzot-Garcher, Cécile Delcourt
PURPOSE: In numerous epidemiological studies, omega-3 polyunsaturated fatty acids (PUFAs) have been associated with a decreased risk of age-related macular degeneration (AMD). Beyond their structural, functional and neuroprotective roles, omega-3 PUFAs may favour the retinal accumulation of lutein and zeaxanthin and thus increase macular pigment optical density (MPOD). We examined the associations of MPOD with plasma omega-3 PUFAs in subjects with family history of AMD. METHODS: The Limpia study is a double-blind, placebo-controlled, prospective randomized clinical trial performed in 120 subjects...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28269075/early-diagnosis-of-nafld-nash-transition-using-mid-infrared-spectroscopy
#11
Siouar Bensaid, Amar Kachenoura, Nathalie Costet, Victor De Ledinghen, Julien Vergniol, Fabrice Laine, Bruno Turlin, Hugues Tariel, Lotfi Senhadji
Non-alcoholic fatty liver disease (NAFLD) is defined as an excessive accumulation of fat in the liver in the absence of excessive drinking of alcohol. Initially considered as benign and self-limited, NAFLD may progress to the malignant stage of non-alcoholic steatohepatitis (NASH) characterized by degenerate hepatocellular ballooning and lobular inflammation. NASH can lead to hepatic fibrosis and ultimately to cirrhosis and hepatocellular carcinoma. Unfortunately, the transition from NAFLD to NASH is difficult to detect so far...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267370/posterior-decentering-of-the-humeral-head-on-shoulder-mr-arthrography-significant-association-with-posterior-synovial-proliferation
#12
Gabin Yun, Yusuhn Kang, Joong Mo Ahn, Eugene Lee, Joon Woo Lee, Joo Han Oh, Heung Sik Kang
OBJECTIVE: The purpose of this study is to analyze MRI findings associated with posterior decentering of the humeral head on shoulder MR arthrogram. MATERIALS AND METHODS: A total of 255 MR arthrograms were obtained during a 10-month period. MR arthrograms in patients with posterior decentering of the humeral head (n = 33) were reviewed and compared with those of randomly selected control group without posterior decentering (n = 66). MR arthrograms were retrospectively evaluated by two observers for posterior factors (posterior synovial proliferation, posterior capsular thickening, and posterior labral abnormality), rotator cuff factors related to fatty degeneration, glenoid version, and anterior factors (subcoracoid bursa effusion and rotator interval tear)...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28246454/molecular-identification-and-histopathological-study-of-natural-streptococcus-agalactiae-infection-in-hybrid-tilapia-oreochromis-niloticus
#13
A A Laith, Mohd Azmi Ambak, Marina Hassan, Shahreza Md Sheriff, Musa Nadirah, Ahmad Shuhaimi Draman, Wahidah Wahab, Wan Nurhafizah Wan Ibrahim, Alia Syafiqah Aznan, Amina Jabar, Musa Najiah
AIM: The main objective of this study was to emphasize on histopathological examinations and molecular identification of Streptococcus agalactiae isolated from natural infections in hybrid tilapia (Oreochromis niloticus) in Temerloh Pahang, Malaysia, as well as to determine the susceptibility of the pathogen strains to various currently available antimicrobial agents. MATERIALS AND METHODS: The diseased fishes were observed for variable clinical signs including fin hemorrhages, alterations in behavior associated with erratic swimming, exophthalmia, and mortality...
January 2017: Veterinary World
https://www.readbyqxmd.com/read/28241791/lipopolysaccharide-mediates-immuno-pathological-alterations-in-young-chicken-liver-through-tlr4-signaling
#14
Xi-Yao Huang, Abdur Rahman Ansari, Hai-Bo Huang, Xing Zhao, Ning-Ya Li, Zhi-Jian Sun, Ke-Mei Peng, Juming Zhong, Hua-Zhen Liu
BACKGROUND: Lipopolysaccharide (LPS) induces acute liver injury and the complex mechanisms include the activation of toll like receptor 4 (TLR4) signaling pathway in many species. However, immuno-pathological changes during TLR4 signaling under LPS stress in acute liver injury is poorly understood in avian species. The present investigation was therefore carried out to evaluate these alterations in TLR4 signaling pathway during acute liver injury in young chickens. RESULTS: After intraperitoneal injection of LPS or saline, liver samples were harvested at 0, 2, 6, 12, 24, 36, 72 and 120 h (n = 6 at each time point) and the microstructures were analyzed by hematoxylin and eosin (H&E) staining...
February 27, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28238963/surgical-repair-of-massive-rotator-cuff-tendon-tears-autologous-quadriceps-tendon-graft-versus-arthroscopic-repair
#15
C Tempelaere, P Desmoineaux, F Lespagnol, J Pierrart, P Beaufils, N Pujol
INTRODUCTION: Massive rotator cuff tear repair results are variable. The main purpose of this study was to compare functional outcome between two procedures: open repair by autologous quadriceps-patella tendon patch, and arthroscopic suture. The study hypothesis was that there is no significant difference in results between the two techniques. MATERIAL AND METHODS: A retrospective study included all patients younger than 70 years operated on from 1995 to 2013 for massive rotator cuff tear...
February 24, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28238066/crocin-inhibits-oxidative-stress-and-pro-inflammatory-response-of-microglial-cells-associated-with-diabetic-retinopathy-through-the-activation-of-pi3k-akt-signaling-pathway
#16
Xinguang Yang, Fuquan Huo, Bei Liu, Jing Liu, Tao Chen, Junping Li, Zhongqiao Zhu, Bochang Lv
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus that is closely associated with the degeneration and loss of retinal ganglion cells (RGCs) caused by diabetic microangiopathy and subsequent oxidative stress and an inflammatory response. Microglial cells are classed as neurogliocytes and play a significant role in neurodegenerative diseases. Over-activated microglial cells may cause neurotoxicity and induce the death and apoptosis of RGCs. Crocin is one of the two most pharmacologically bioactive constituents in saffron...
February 25, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28227294/early-diagnosis-of-nafld-nash-transition-using-mid-infrared-spectroscopy
#17
Siouar Bensaid, Amar Kachenoura, Nathalie Costet, Victor De Ledinghen, Julien Vergniol, Fabrice Laine, Bruno Turlin, Hugues Tariel, Lotfi Senhadji, Siouar Bensaid, Amar Kachenoura, Nathalie Costet, Victor De Ledinghen, Julien Vergniol, Fabrice Laine, Bruno Turlin, Hugues Tariel, Lotfi Senhadji, Hugues Tariel, Siouar Bensaid, Victor De Ledinghen, Fabrice Laine, Bruno Turlin, Lotfi Senhadji, Amar Kachenoura, Julien Vergniol, Nathalie Costet
Non-alcoholic fatty liver disease (NAFLD) is defined as an excessive accumulation of fat in the liver in the absence of excessive drinking of alcohol. Initially considered as benign and self-limited, NAFLD may progress to the malignant stage of non-alcoholic steatohepatitis (NASH) characterized by degenerate hepatocellular ballooning and lobular inflammation. NASH can lead to hepatic fibrosis and ultimately to cirrhosis and hepatocellular carcinoma. Unfortunately, the transition from NAFLD to NASH is difficult to detect so far...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224229/structural-changes-in-the-thigh-muscles-following-trans-femoral-amputation
#18
C Putz, J Block, S Gantz, D W W Heitzmann, T Dreher, B Lehner, M Alimusaj, S I Wolf, S Müller
INTRODUCTION: Early ambulation is the principal objective in trans-femoral amputees. Postamputation modifications complicate the rehabilitation process due to a reduced control at the interface between stump and prosthesis. The aim of this study is to determine whether magnetic resonance imaging depicts the amount of fatty degeneration of the thigh muscles after trans-femoral amputation (TFA). METHODS: A total of 12 patients following a TFA on the basis of a bone neoplasm or metastasis with an evaluable postoperative MRI were identified...
February 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28219158/-experimental-observation-on-the-histopathological-and-ultrastructural-pathology-of-great-gerbils-rhombomys-opimus-in-the-junggar-basin-by-subcutaneous-injecting-of-yersinia-pestis
#19
B Li, Rehemu Azhati, W W Meng, T Luo, B Li, Maituohuti Abulimiti, X H Wang, X Dai, Y J Zhang
Objective: To understand the histopathological and ultrastructural pathology changes of great gerbils in the Junggar Basin to Yersinia pestis infection. Methods: Forty captured great gerbils from the Junggar Basin that tested negative for anti-F1 antibodies were infected. The Y. pestis strain 2504, isolated from a live great gerbil in the natural plague foci of the Junggar Basin in 2005 with a median lethal dose (LD(50)) of <10 CFU/ml, was used in this study. Forty great gerbils were divided into seven infection groups and were subcutaneously infected with 7...
February 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28218887/pathology-of-serially-sacrificed-female-b6c3f1-mice-chronically-exposed-to-very-low-dose-rate-gamma-rays
#20
I B Tanaka, J Komura, S Tanaka
We have previously reported on life span shortening as well as increased incidence rates in several neoplasms in B6C3F1 mice that were continuously exposed to 21 mGy/day of gamma rays for 400 days. To clarify whether the life shortening was due to early appearance of neoplasms (shortened latency) or increased promotion/progression, 8-week-old female specific-pathogen-free B6C3F1 mice were gamma-ray irradiated at a low dose rate of 20 mGy/day for 400 days. At 100 days postirradiation, 60-90 mice were sacrificed, and thereafter every 100 days alongside the age-matched nonirradiated controls, for 700 days...
February 20, 2017: Radiation Research
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