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https://www.readbyqxmd.com/read/28219158/-experimental-observation-on-the-histopathological-and-ultrastructural-pathology-of-great-gerbils-rhombomys-opimus-in-the-junggar-basin-by-subcutaneous-injecting-of-yersinia-pestis
#1
B Li, Rehemu Azhati, W W Meng, T Luo, B Li, Maituohuti Abulimiti, X H Wang, X Dai, Y J Zhang
Objective: To understand the histopathological and ultrastructural pathology changes of great gerbils in the Junggar Basin to Yersinia pestis infection. Methods: Forty captured great gerbils from the Junggar Basin that tested negative for anti-F1 antibodies were infected. The Y. pestis strain 2504, isolated from a live great gerbil in the natural plague foci of the Junggar Basin in 2005 with a median lethal dose (LD(50)) of <10 CFU/ml, was used in this study. Forty great gerbils were divided into seven infection groups and were subcutaneously infected with 7...
February 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28218887/pathology-of-serially-sacrificed-female-b6c3f1-mice-chronically-exposed-to-very-low-dose-rate-gamma-rays
#2
I B Tanaka, J Komura, S Tanaka
We have previously reported on life span shortening as well as increased incidence rates in several neoplasms in B6C3F1 mice that were continuously exposed to 21 mGy/day of gamma rays for 400 days. To clarify whether the life shortening was due to early appearance of neoplasms (shortened latency) or increased promotion/progression, 8-week-old female specific-pathogen-free B6C3F1 mice were gamma-ray irradiated at a low dose rate of 20 mGy/day for 400 days. At 100 days postirradiation, 60-90 mice were sacrificed, and thereafter every 100 days alongside the age-matched nonirradiated controls, for 700 days...
February 20, 2017: Radiation Research
https://www.readbyqxmd.com/read/28166636/cartilaginous-metabolomic-study-reveals-potential-mechanisms-of-osteophyte-formation-in-osteoarthritis
#3
Zhongwei Xu, Tingmei Chen, Jiao Luo, Shijia Ding, Sichuan Gao, Jian Zhang
Osteophyte is one of the inevitable consequences of progressive osteoarthritis with the main characteristics of cartilage degeneration and endochondral ossification. The pathogenesis of osteophyte formation is not fully understood to date. In this work, metabolomic approaches were employed to explore potential mechanisms of osteophyte formation by detecting metabolic variations between extracts of osteophyte cartilage tissues (n = 32) and uninvolved control cartilage tissues (n = 34), based on the platform of ultraperformance liquid chromatography tandem quadrupole time-of-flight mass spectrometry, as well as the use of multivariate statistic analysis and univariate statistic analysis...
February 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28166085/when-the-laughing-stops-subacute-combined-spinal-cord-degeneration-caused-by-laughing-gas-use
#4
Annemiek Buizert, Ruby Sharma, Hille Koppen
Here we describe a case of subacute combined spinal cord degeneration caused by nitrous oxide (N2O, laughing gas) use. Because of its euphoric effects, the use of N2O has become increasingly popular in recent years. Unfortunately, the use of N2O leads to inactivation of vitamin B12. Vitamin B12 plays an essential role in the synthesis and maintenance of myelin, a fatty substance that surrounds nerve cells and is crucial for their functioning. Deficiency of vitamin B12 could typically result in degeneration of posterior and lateral columns of the spinal cord...
February 3, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28154734/nutritional-and-lifestyle-interventions-for-age-related-macular-degeneration-a-review
#5
REVIEW
Ângela Carneiro, José Paulo Andrade
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. In this narrative review, we will summarize the nutritional interventions evaluated in numerous observational studies and a few randomized clinical trials. The AREDS and AREDS2 studies demonstrated that supplements including vitamins C and E, beta-carotene, and zinc may reduce the progression to advanced AMD, in some patients, by 25% in five years. This is one of the few nutritional supplements known to have beneficial effects in any eye disease...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28153441/dietary-intakes-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-and-risk-of-age-related-macular-degeneration
#6
Juan Wu, Eunyoung Cho, Edward L Giovannucci, Bernard A Rosner, Srinivas M Sastry, Walter C Willett, Debra A Schaumberg
PURPOSE: To evaluate the associations between intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the intermediate and advanced stages of age-related macular degeneration (AMD). DESIGN: Prospective cohort study. PARTICIPANTS: We followed 75 889 women from the Nurses' Health Study and 38 961 men from the Health Professionals Follow-Up Study who were at least 50 years old, from 1984 to 2012 and 1986 to 2010, respectively...
January 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28131694/neer-award-2016-reduced-muscle-degeneration-and-decreased-fatty-infiltration-after-rotator-cuff-tear-in-a-poly-adp-ribose-polymerase-1-parp-1-knock-out-mouse-model
#7
Michael B Kuenzler, Katja Nuss, Agnieszka Karol, Michael O Schär, Michael Hottiger, Sumit Raniga, David Kenkel, Brigitte von Rechenberg, Matthias A Zumstein
BACKGROUND: Disturbed muscular architecture, atrophy, and fatty infiltration remain irreversible in chronic rotator cuff tears even after repair. Poly (adenosine 5'-diphosphate-ribose) polymerase 1 (PARP-1) is a key regulator of inflammation, apoptosis, muscle atrophy, muscle regeneration, and adipocyte development. We hypothesized that the absence of PARP-1 would lead to a reduction in damage to the muscle subsequent to combined tenotomy and neurectomy in a PARP-1 knockout (KO) mouse model...
January 25, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28127199/mitochondrial-carnitine-palmitoyl-transferase-ii-inactivity-aggravates-lipid-accumulation-in-rat-hepatocarcinogenesis
#8
Juan-Juan Gu, Min Yao, Jie Yang, Yin Cai, Wen-Jie Zheng, Li Wang, Deng-Bing Yao, Deng-Fu Yao
AIM: To investigate the dynamic alteration of mitochondrial carnitine palmitoyl transferase II (CPT-II) expression during malignant transformation of rat hepatocytes. METHODS: Sprague-Dawley male rats were fed with normal, high fat (HF), and HF containing 2-fluorenylacetamide (2-FAA) diet, respectively. According to the Hematoxylin and Eosin staining of livers, rats were divided into control, fatty liver, degeneration, precancerous, and cancerous groups. Liver lipids were dyed with Oil Red O, CPT-II alterations were analyzed by immunohistochemistry, and compared with CPT-II specific concentration (μg/mg protein)...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28101634/is-the-arthroscopic-suture-bridge-technique-suitable-for-full-thickness-rotator-cuff-tears-of-any-size
#9
Sung Hyun Lee, Jeong Woo Kim, Tae Kyun Kim, Seok Hyun Kweon, Hong Je Kang, Se Jin Kim, Jin Sung Park
PURPOSE: The purpose of this study was to compare functional outcomes and tendon integrity between the suture bridge and modified tension band techniques for arthroscopic rotator cuff repair. METHODS: A consecutive series of 128 patients who underwent the modified tension band (MTB group; 69 patients) and suture bridge (SB group; 59 patients) techniques were enrolled. The pain visual analogue scale (VAS), Constant, and American Shoulder and Elbow Surgeons (ASES) scores were determined preoperatively and at the final follow-up...
January 18, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28096126/the-age-related-eye-disease-2-study-micronutrients-in-the-treatment-of-macular-degeneration
#10
REVIEW
Aruna Gorusupudi, Kelly Nelson, Paul S Bernstein
Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. With an increasingly aged population worldwide, the need for the prevention of AMD is rising. Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress-related retinal damage as an important contributing factor. In general, diet is an excellent source of the antioxidants, vitamins, and minerals necessary for healthy living; moreover, the general public is often receptive to recommendations made by physicians and health care workers regarding diet and supplements as a means of empowering themselves to avoid common and worrisome ailments such as AMD, which has made epidemiologists and clinicians enthusiastic about dietary intervention studies...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28094305/association-of-the-intestinal-microbiome-with-the-development-of-neovascular-age-related-macular-degeneration
#11
Martin S Zinkernagel, Denise C Zysset-Burri, Irene Keller, Lieselotte E Berger, Alexander B Leichtle, Carlo R Largiadèr, Georg M Fiedler, Sebastian Wolf
Age-related macular degeneration (AMD) is the most frequent cause of blindness in the elderly. There is evidence that nutrition, inflammation and genetic risk factors play an important role in the development of AMD. Recent studies suggest that the composition of the intestinal microbiome is associated with metabolic diseases through modulation of inflammation and host metabolism. To investigate whether compositional and functional alterations of the intestinal microbiome are associated with AMD, we sequenced the gut metagenomes of patients with AMD and controls...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28092213/cellular-and-molecular-factors-influencing-tendon-repair
#12
Sushmitha Durgam, Matthew Stewart
Tendons are complex, hierarchically organized connective tissues that transmit tensile forces between muscles and tendons. Tendon injuries are among the most common orthopedic problems with long-term disability as a frequent consequence due to prolonged healing time. Further, the repair tissue is of inferior quality, predisposing patients to high rates of recurrence following initial injury. Co-ordinated cellular processes and biological factors under the influence of mechanical loading are involved in tendon healing and our understanding of these events lags behind other musculoskeletal tissues...
January 16, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28089257/the-natural-course-of-nonoperatively-treated-rotator-cuff-tears-an-8-8-year-follow-up-of-tear-anatomy-and-clinical-outcome-in-49-patients
#13
Stefan Moosmayer, Anne V Gärtner, Rana Tariq
BACKGROUND: The natural course of nonoperatively treated rotator cuff tears is not fully understood. We explored the long-term development of tear anatomy and assessed functional outcomes. METHODS: Eighty-nine small to medium-sized full-thickness tears of the rotator cuff, all primarily treated by physiotherapy, were identified retrospectively. Twenty-three tears needed surgical treatment later on, and 17 patients were unable to meet for follow-up. The remaining 49 still unrepaired tears were re-examined after 8...
January 12, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28064003/a-semi-automated-quantitative-ct-method-for-measuring-rotator-cuff-muscle-degeneration-in-shoulders-with-primary-osteoarthritis
#14
Alexandre Terrier, Julien Ston, Antoine Dewarrat, Fabio Becce, Alain Farron
BACKGROUND: Rotator cuff muscle degeneration is an important parameter to consider when planning shoulder arthroplasty. HYPOTHESIS: We hypothesized that rotator cuff muscle degeneration is correlated with scapulohumeral subluxation in patients planned for anatomical total shoulder arthroplasty (TSA). MATERIALS AND METHODS: We developed a semi-automated quantitative CT method to measure rotator cuff muscle degeneration, and retrospectively analyzed 107 preoperative shoulder CT scans of patients with primary osteoarthritis...
January 4, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28045098/effects-of-elevated-%C3%AE-estradiol-levels-on-the-functional-morphology-of-the-testis-new-insights
#15
Myles Leavy, Matthias Trottmann, Bernhard Liedl, Sven Reese, Christian Stief, Benjamin Freitag, John Baugh, Giulio Spagnoli, Sabine Kölle
Elevated estradiol levels are correlated with male infertility. Causes of hyperestrogenism include diseases of the adrenal cortex, testis or medications affecting the hypothalamus-pituitary-gonadal axis. The aim of our study was to elucidate the effects of estradiol treatment on testicular cellular morphology and function, with reference to the treatment regimen received. Testes samples (n = 9) were obtained post-orchiectomy from male-to-female transsexuals within the age range of 26-52 years. Each patient had a minimum of 1-6 years estradiol treatment...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043489/morphological-changes-in-experimental-tuberculosis-resulting-from-treatment-with-quercetin-and-polyvinylpyrrolidone
#16
Tatyana Butova, Svetlana Zaitseva, Dmytro Butov, Ganna Stepanenko
OBJECTIVE/BACKGROUND: Morphological study of a mice of tissue necrosis stages in experimental organ-preserving tuberculosis (TB) pharmacotherapy using quercetin and polyvinylpyrrolidone (QP). METHODS: A total of 32 laboratory mice of C57BL/6JLacSto strain were used in the experiment. The animals were divided into five groups (Group 1-5), with six to seven mice in each group: Group 1, Mycobacterium tuberculosis (MBT)-uninfected mice; Group 2, MBT-infected mice; Group 3, MBT infected and treated with anti-TB preparation (ATP); Group 4, MBT infected and QP treated; and Group 5, MBT infected and treated with ATP and QP...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28030812/aflatoxin-b1-invokes-apoptosis-via-death-receptor-pathway-in-hepatocytes
#17
Muhammad Jameel Mughal, Peng Xi, Zhou Yi, Fang Jing
The fungal metabolites produced by Aspergillus flavus and Aspergillus parasiticus cause detrimental health effects on humans and animals. Particularly aflatoxin B1 (AFB1) is the most studied and a well-known global carcinogen, producing hepatotoxic, genotoxic and immunotoxic effects in multiple species. AFB1 is shown to provoke liver dysfunctioning by causing hepatocytes apoptosis and disturbing cellular enzymatic activities. In liver, AFB1 causes apoptosis via extrinsic mechanism because of high expression of death receptor pathway...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28017249/slowly-progressive-d-bifunctional-protein-deficiency-with-survival-to-adulthood-diagnosed-by-whole-exome-sequencing
#18
Takashi Matsukawa, Kagari Mano Koshi, Jun Mitsui, Taro Bannai, Miho Kawabe, Hiroyuki Ishiura, Yasuo Terao, Jun Shimizu, Keiko Murayama, Jun Yoshimura, Koichiro Doi, Shinichi Morishita, Shoji Tsuji, Jun Goto
d-Bifunctional protein (DBP) deficiency is an autosomal recessive disorder of peroxisomal fatty acid oxidation caused by mutations in HSD17B4. It is typically fatal by the age of two years with symptom onset during the neonatal period, and survival until late childhood is rare. We herein report the case of a patient with DBP deficiency surviving until adulthood, who showed severe sensorineural deafness, disturbances in language acquisition, slowly progressive cerebellar ataxia, and peripheral neuropathy. This patient, in whom findings of prior investigations were nondiagnostic, had been followed up as having an early-onset spinocerebellar degeneration of unknown etiology...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28005753/motor-nerve-preservation-and-muscle-atrophy-after-pectoralis-major-musculocutaneous-flap-surgery-for-oromandibular-reconstruction
#19
Yu Takayama, Satoshi Yokoo, Takaya Makiguchi, Takahide Komori
OBJECTIVE: The authors investigated the clinical and histopathologic significance of medial pectoral nerve preservation/reinnervation of pectoralis major musculocutaneous flap for oromandibular reconstruction. MATERIALS AND METHODS: The authors compared 13 patients treated with pectoralis major musculocutaneous flap reconstruction and 6 control patients treated by rectus abdominis musculocutaneous flap reconstruction without motor nerve restoration. Subjective awareness was scored to evaluate changes in the facial contour due to muscle atrophy, and objective evaluation was performed in few patients...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28004277/tauroursodeoxycholic-bile-acid-arrests-axonal-degeneration-by-inhibiting-the-unfolded-protein-response-in-x-linked-adrenoleukodystrophy
#20
Nathalie Launay, Montserrat Ruiz, Laia Grau, Francisco J Ortega, Ekaterina V Ilieva, Juan José Martínez, Elena Galea, Isidre Ferrer, Erwin Knecht, Aurora Pujol, Stéphane Fourcade
The activation of the highly conserved unfolded protein response (UPR) is prominent in the pathogenesis of the most prevalent neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), which are classically characterized by an accumulation of aggregated or misfolded proteins. This activation is orchestrated by three endoplasmic reticulum (ER) stress sensors: PERK, ATF6 and IRE1. These sensors transduce signals that induce the expression of the UPR gene programme...
February 2017: Acta Neuropathologica
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