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https://www.readbyqxmd.com/read/29137649/exploring-the-factors-affecting-the-implementation-of-tobacco-and-substance-use-interventions-within-a-secondary-school-setting-a-systematic-review
#1
REVIEW
Gillian Waller, Tracy Finch, Emma L Giles, Dorothy Newbury-Birch
BACKGROUND: The aim of this mixed-methods, systematic literature review was to develop an understanding of the factors affecting the implementation of tobacco and substance use intervention programmes in the secondary school setting using NPT as an analytical framework. METHODS: A search strategy was developed that combined implementation, school and intervention search terms. Literature searches were conducted in MEDLINE, Embase, PsycHINFO, Scopus, ERIC, CINAHL, Web of Science and the Cochrane Library...
November 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29130983/prevalence-and-clinical-characteristics-of-local-allergic-rhinitis-in-children-sensitized-to-house-dust-mites
#2
Eun Kyo Ha, Min Sun Na, Shinhae Lee, Heysung Baek, Seung Jin Lee, Youn Ho Sheen, Young-Ho Jung, Kyung Suk Lee, Mi Ae Kim, Hye Mi Jee, Man Yong Han
OBJECTIVE: The prevalence of local allergic rhinitis (LAR) in nonatopic children remains unknown. This study aimed to determine the prevalence, clinical characteristics, and severity of LAR in children in comparison to classical allergic rhinitis (AR) and nonallergic rhinitis (NAR). STUDY DESIGN: A total of 145 children (aged 1-18 years) were enrolled and classified into 3 groups (AR, NAR, and LAR) based on a skin prick test (SPT) and a nasal provocation test (NPT) with house dust mite, i...
November 10, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29118971/local-allergic-rhinitis-evolution-of-concepts
#3
EDITORIAL
Cristoforo Incorvaia, Nicola Fuiano, Irene Martignago, Bruna L Gritti, Erminia Ridolo
The discovery of an exclusive local production of IgE antibodies dates back to the 1970s, but only recently the pathophysiology of such phenomenon was deeply investigated, leading to the concept of local allergic rhinitis (LAR). Currently, LAR is defined by the occurrence, in patients with symptoms clearly suggesting allergic rhinitis but with negative results to common allergy testing, of allergen specific IgE in the nasal mucosa. Most studies investigating LAR were based on the development of rhinitis symptoms following nasal provocation test (NPT) with the suspected allergens, but such test may be performed by a number of options, none of them being as yet acknowledged and recommended in consensus document...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29114425/relationships-between-initial-probing-depth-and-changes-in-the-clinical-parameters-following-non-surgical-periodontal-treatment-in-chronic-periodontitis
#4
Suleyman Emre Meseli, Bahar Kuru, Leyla Kuru
Purpose: The aim of this study was to evaluate the relationship between initial probing depth (IPD) and changes in clinical parameters following non-surgical periodontal treatment (NPT) in chronic periodontitis patients. Subjects and Methods: A total of 1672 periodontal pockets having 3mm≤IPD≤9mm of depth in 15 chronic periodontitis patients were included. NPT consisting of oral hygiene instructions, scaling and root planing was applied in two sessions. Probing depth (PD), clinical attachment level, gingival recessions (GR) were measured before and eight weeks after treatment...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/29096645/benzoylphenyl-thiocyanates-are-new-effective-inhibitors-of-the-mycobacterial-resuscitation-promoting-factor-b-protein
#5
Galina R Demina, Vadim D Nikitushkin, Margarita O Shleeva, Olga B Riabova, Alexander Yu Lepioshkin, Vadim A Makarov, Arseny S Kaprelyants
BACKGROUND: Resuscitation promoting factors (Rpfs) are the proteins involved in the process of reactivation of the dormant cells of mycobacteria. Recently a new class of nitrophenylthiocyanates (NPTs), capable of inhibiting the biological and enzymatic activities of Rpfs has been discovered. In the current study the inhibitory properties of the compounds containing both nitro and thiocyanate groups alongside with the compounds with the modified number and different spatial location of the substituents are compared...
November 2, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29090986/prophylactic-negative-pressure-wound-therapy-in-obese-patients-following-cesarean-delivery
#6
Maureen Ayers Looby, Rachel Isaksson Vogel, Ananta Bangdiwala, Barbara Hyer, Kamalini Das
OBJECTIVE: Negative pressure therapy (NPT) offers the potential to reduce infection in obese patients. The goal of this study was to explore the association between NPT use and infection after cesarean delivery among obese women. METHODS: We initiated a hospital protocol wherein women with a body mass index (BMI) of 40 kg/m(2) or greater who delivered after January 1, 2011 were to receive NPT following cesarean section. A retrospective comparison of surgical site infection (SSI) in women receiving the intervention to a similar group with a BMI of 40 kg/m(2) or greater, a historical control group of women who delivered before January 1, 2011...
October 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29089736/early-experience-with-laparoscopic-management-of-nonpalpable-undescended-testes
#7
Okechukwu Hyginus Ekwunife, Victor Ifeanyichukwu Modekwe, Jideofor Okechukwu Ugwu, Chuka Abunike Ugwunne
BACKGROUND: Nonpalpable undescended testes (NPT) constitute 20%-30% of undescended testes, and its management has been a challenge both in diagnosis and treatment. Worldwide, laparoscopy is the current gold standard of management. In Nigeria, the management of NPT has largely been by open surgery with consequent high morbidity. In Nigeria, the trend is changing from a largely open management with its attendant high morbidity, to laparoscopic management which is the current worldwide gold standard of care...
July 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29089695/intra-abdominal-pressure-monitoring-in-open-abdomen-management-with-dynamic-abdominal-closure
#8
A Ebru Sarer, Fahri Yetisir, Muhittin Aygar, Hasan Zafer Acar, Yılmaz Polat, Gokhan Osmanoglu
The importance of elevated intra-abdominal pressure (IAP) and abdominal compartment syndrome (ACS) have been recognized in critical care for its potential damaging effects. But, quantification of IAP values may be useful as a clinical tool for determining efficacy of coughing and straining for functional recovery of OA patients. We would like to evaluate IAP generated in an OA patient and the effect of negative pressure therapy (NPT) and dynamic abdominal closure systems (ABRA) on the IAP values at rest and during coughing and straining and compare those with IAP measurements of closed abdomen after standard open elective colorectal surgery (non-OA)...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29063783/iron-therapy-substantially-restores-qeeg-maturational-lag-among-iron-deficient-anemic-infants
#9
Gloria A Otero, Thalía Fernández, F Bernardo Pliego-Rivero, Gustavo G Mendieta
OBJECTIVE: To use quantitative electroencephalography (qEEG) to assess the impact of iron-deficiency anemia on central nervous system maturation in the first year of life. METHOD: Twenty-five infants (3-12 months old) presenting ferropenic anemia (IDA) and 25 healthy controls (CTL1), matched by age/gender with the former, were studied in two stages. Electroencephalogram during spontaneous sleep was recorded from all participants; the fast Fourier transform was calculated to obtain absolute power (AP) and relative power (RP) qEEG measures...
October 24, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29059412/barriers-to-using-nonpharmacologic-approaches-and-reducing-opioid-use-in-primary-care
#10
Karleen F Giannitrapani, Sangeeta C Ahluwalia, Matthew McCaa, Maura Pisciotta, Steven Dobscha, Karl A Lorenz
Background: Opioid prescribing for chronic pain, including the potential for over-reliance and misuse, is a public health concern. Objective: In the context of Veterans Administration (VA) primary care team-based pain management, we aimed to understand providers' perceptions of barriers to reducing opioid use and improving the use of nonpharmacologic pain management therapies (NPTs) for chronic pain. Design: A semistructured interview elucidated provider experiences with assessing and managing pain...
October 20, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29026294/comparison-of-the-peripheral-blood-eosinophil-count-using-near-patient-testing-and-standard-automated-laboratory-measurement-in-healthy-asthmatic-and-copd-subjects
#11
Kirsty Hambleton, Clare M Connolly, Catherine Borg, Joanne H Davies, Helen P Jeffers, Richard Ek Russell, Mona Bafadhel
Near-patient testing (NPT) allows clinical decisions to be made in a rapid and convenient manner and is often cost effective. In COPD the peripheral blood eosinophil count has been demonstrated to have utility in providing prognostic information and predicting response to treatment during an acute exacerbation. For this potential to be achieved having a reliable NPT of blood eosinophil count would be extremely useful. Therefore, we investigated the use of the HemoCue(®) WBC Diff System and evaluated its sensitivity and specificity in healthy, asthmatic and COPD subjects...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28988176/implementing-communication-and-decision-making-interventions-directed-at-goals-of-care-a-theory-led-scoping-review
#12
Amanda Cummings, Susi Lund, Natasha Campling, Carl R May, Alison Richardson, Michelle Myall
OBJECTIVES: To identify the factors that promote and inhibit the implementation of interventions that improve communication and decision-making directed at goals of care in the event of acute clinical deterioration. DESIGN AND METHODS: A scoping review was undertaken based on the methodological framework of Arksey and O'Malley for conducting this type of review. Searches were carried out in Medline and Cumulative Index to Nursing and Allied Health Literature (CINAHL) to identify peer-reviewed papers and in Google to identify grey literature...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28980073/ligro-a-graphical-user-interface-for-protein-ligand-molecular-dynamics
#13
Luciano Porto Kagami, Gustavo Machado das Neves, Alan Wilter Sousa da Silva, Rafael Andrade Caceres, Daniel Fábio Kawano, Vera Lucia Eifler-Lima
To speed up the drug-discovery process, molecular dynamics (MD) calculations performed in GROMACS can be coupled to docking simulations for the post-screening analyses of large compound libraries. This requires generating the topology of the ligands in different software, some basic knowledge of Linux command lines, and a certain familiarity in handling the output files. LiGRO-the python-based graphical interface introduced here-was designed to overcome these protein-ligand parameterization challenges by allowing the graphical (non command line-based) control of GROMACS (MD and analysis), ACPYPE (ligand topology builder) and PLIP (protein-binder interactions monitor)-programs that can be used together to fully perform and analyze the outputs of complex MD simulations (including energy minimization and NVT/NPT equilibration)...
October 4, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28970706/brain-microstructural-correlates-of-cognitive-dysfunction-in-clinically-and-biochemically-normal-hepatitis-c-virus-infection
#14
Ajay Kumar, Amar Deep, Rakesh K Gupta, Virendra Atam, Samir Mohindra
BACKGROUND/AIMS: This study examined correlates of the brain's neurocognitive performance among clinically and biochemically normal adult patient with hepatitis C virus (HCV). We hypothesized that anti-HCV positive individuals would demonstrate structural brain abnormalities and neurocognitive dysfunction as well as the changes in cell component and extracellular space in the white matter regions of brain in asymptomatic HCV infection by using diffusion tensor tractrography (DTT) metrics...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28940698/improvement-of-wound-healing-by-regulated-oxygen-enriched-negative-pressure-assisted-wound-therapy-in-a-rabbit-model
#15
Y Z Li, X D Hu, X M Lai, Y F Li, Y Lei
BACKGROUND: Development of drug therapies and other techniques for wound care have resulted in significant improvement of the cure rate and shortening of the healing time for wounds. A modified technique of regulated oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) has been reported. AIM: To evaluate the efficacy and impact of RO-NPT on wound recovery and inflammation. METHODS: Infected wounds were established on 40 adult female white rabbits, which were then randomized to one of four groups: O2 group, regulated negative pressure-assisted wound therapy (RNPT) group, regulated oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) group and healthy control (HC) group...
September 21, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28940058/functional-cardiotoxicity-assessment-of-cosmetic-compounds-using-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#16
Umesh Chaudhari, Harshal Nemade, Poornima Sureshkumar, Mathieu Vinken, Gamze Ates, Vera Rogiers, Jürgen Hescheler, Jan Georg Hengstler, Agapios Sachinidis
There is a large demand of a human relevant in vitro test system suitable for assessing the cardiotoxic potential of cosmetic ingredients and other chemicals. Using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), we have already established an in vitro cardiotoxicity assay and identified genomic biomarkers of anthracycline-induced cardiotoxicity in our previous work. Here, five cosmetic ingredients were studied by the new hiPSC-CMs test; kojic acid (KJA), triclosan (TS), triclocarban (TCC), 2,7-naphthalenediol (NPT), and basic red 51 (BR51) based on cytotoxicity as well as ATP assays, beating rate, and genomic biomarkers to determine the lowest observed effect concentration (LOEC) and no observed effect concentration (NOEC)...
September 22, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28936925/gay-men-s-understanding-and-education-of-new-hiv-prevention-technologies-in-vancouver-canada
#17
Benjamin J Klassen, Nathan J Lachowsky, Sally Yue Lin, Joshua B Edward, Sarah A Chown, Robert S Hogg, David M Moore, Eric A Roth
Effective rollout of HIV treatment-based prevention such as pre-exposure prophylaxis and treatment as prevention has been hampered by poor education, limited acceptability, and stigma among gay men. We undertook a thematic analysis regarding the education sources and acceptability of these New Prevention Technologies (NPTs) using 15 semistructured interviews with gay men in Vancouver, Canada, who were early adopters of NPTs. NPT education was derived from a variety of sources, including the Internet, health care providers, community organizations, sexual partners, and peers; participants also emphasized their own capacities as learners and educators...
October 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28929235/comparative-studies-on-structures-mechanical-properties-sensitivity-stabilities-and-detonation-performance-of-cl-20-tnt-cocrystal-and-composite-explosives-by-molecular-dynamics-simulation
#18
Gui-Yun Hang, Wen-Li Yu, Tao Wang, Jin-Tao Wang, Zhen Li
To investigate and compare the differences of structures and properties of CL-20/TNT cocrystal and composite explosives, the CL-20/TNT cocrystal and composite models were established. Molecular dynamics simulations were performed to investigate the structures, mechanical properties, sensitivity, stabilities and detonation performance of cocrystal and composite models with COMPASS force field in NPT ensemble. The lattice parameters, mechanical properties, binding energies, interaction energy of trigger bond, cohesive energy density and detonation parameters were determined and compared...
September 19, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28919839/ground-up-top-down-a-mixed-method-action-research-study-aimed-at-normalising-research-in-practice-for-nurses-and-midwives
#19
Vicki Parker, Gena Lieschke, Michelle Giles
BACKGROUND: Improving health, patient and system outcomes through a practice-based research agenda requires infrastructural supports, leadership and capacity building approaches, at both the individual and organisational levels. Embedding research as normal nursing and midwifery practice requires a flexible approach that is responsive to the diverse clinical contexts within which care is delivered and the variable research skills and interest of clinicians. This paper reports the study protocol for research being undertaken in a Local Health District (LHD) in New South Wales (NSW) Australia...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28895580/new-path-towards-a-better-rice-architecture
#20
Reynante L Ordonio, Makoto Matsuoka
New plant type (NPT) or ideal plant architecture (IPA) is an attractive way of increasing yield potential by promoting high resource use efficiency combined with better lodging resistance. In a recent paper in Cell Research, Wang et al. describe how a QTL they identified could bring about the desired NPT architecture by elucidating the role of its encoded gene in controlling the stability of IPA1/OsSPL14, a previously reported NPT protein, in the context of ubiquitination.
October 2017: Cell Research
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