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https://www.readbyqxmd.com/read/29792212/the-role-of-human-metapneumovirus-genetic-diversity-and-nasopharyngeal-viral-load-on-symptom-severity-in-adults
#1
Xiang Yong Oong, Jack Bee Chook, Kim Tien Ng, Wei Zhen Chow, Kok Gan Chan, Nik Sherina Hanafi, Yong Kek Pang, Yoke Fun Chan, Adeeba Kamarulzaman, Kok Keng Tee
BACKGROUND: Human metapneumovirus (HMPV) is established as one of the causative agents of respiratory tract infections. To date, there are limited reports that describe the effect of HMPV genotypes and/or viral load on disease pathogenesis in adults. This study aims to determine the role of HMPV genetic diversity and nasopharyngeal viral load on symptom severity in outpatient adults with acute respiratory tract infections. METHODS: Severity of common cold symptoms of patients from a teaching hospital was assessed by a four-category scale and summed to obtain the total symptom severity score (TSSS)...
May 23, 2018: Virology Journal
https://www.readbyqxmd.com/read/29789723/a-potential-cure-for-the-common-cold
#2
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29788356/return-to-duty-rates-following-minimally-invasive-spine-surgery-performed-on-active-duty-military-patients-in-an-ambulatory-surgery-center
#3
Elder Granger, Stefan Prada, Zoltan Bereczki, Michael Weiss, Chip Wade, Reginald Davis
Background: Low back pain is a primary health care utilization driver in the US population. Health care evaluation visits for low back pain are as common as medical evaluation for the common cold. Low back pain is the most common reason for reductions in activities of daily living and work activity in the general population. Although these statistics are compelling, in the military population, there is arguably a significantly greater economic impact on the military population, as the cost to train, retain, and deploy a service member is a tremendous cost...
May 21, 2018: Military Medicine
https://www.readbyqxmd.com/read/29786498/hcov-229e-spike-protein-fusion-activation-by-trypsin-like-serine-proteases-is-mediated-by-proteolytic-processing-in-the-s2-region
#4
Ariane Bonnin, Adeline Danneels, Jean Dubuisson, Anne Goffard, Sandrine Belouzard
Human coronavirus 229E (HCoV-229E) is responsible for common colds. Like other coronaviruses, HCoV-229E exploits cellular proteases to activate fusion mediated by the spike protein. We analysed the proteolytic processing of the HCoV-229E spike protein by trypsin-like serine proteases leading to activation of the fusion process. Unlike in other coronaviruses, HCoV-229E fusion activation appears to be a one-step process. Indeed, cleavage of the S1/S2 interface does not seem to be a prerequisite, and the fusion activation is highly reliant on the S2' region, with arginine residue 683 acting as the recognition site...
May 22, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29778173/human-viral-pathogens-are-pervasive-in-wastewater-treatment-center-aerosols
#5
Evelyne Brisebois, Marc Veillette, Vanessa Dion-Dupont, Jacques Lavoie, Jacques Corbeil, Alexander Culley, Caroline Duchaine
Wastewater treatment center (WTC) workers may be vulnerable to diseases caused by viruses, such as the common cold, influenza and gastro-intestinal infections. Although there is a substantial body of literature characterizing the microbial community found in wastewater, only a few studies have characterized the viral component of WTC aerosols, despite the fact that most diseases affecting WTC workers are of viral origin and that some of these viruses are transmitted through the air. In this study, we evaluated in four WTCs the presence of 11 viral pathogens of particular concern in this milieu and used a metagenomic approach to characterize the total viral community in the air of one of those WTCs...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29768343/potential-common-factors-associated-with-predisposition-to-common-cold-in-middle-aged-and-elderly-japanese-a-community-based-cross-sectional-study
#6
Michi Shibata, Taizo Iwane, Ryoko Higuchi, Kaname Suwa, Kei Nakajima
People worldwide frequently catch a common cold, which occasionally develops into secondary severe conditions such as pneumonia. However, it is unclear whether predisposition to the common cold is associated with the individual's characteristics including age, body weight, lifestyles, diets, and intestinal functions, besides exposure to a responsible pathogen. We addressed this issue epidemiologically considering many relevant clinical factors.We reviewed data from a cross-sectional study consisting of 39,524 apparently healthy Japanese aged 40 to 79 years (26,975 men and 12,549 women) who underwent a checkup in 2007...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29760414/fragment-derived-inhibitors-of-human-n-myristoyltransferase-block-capsid-assembly-and-replication-of-the-common-cold-virus
#7
Aurélie Mousnier, Andrew S Bell, Dawid P Swieboda, Julia Morales-Sanfrutos, Inmaculada Pérez-Dorado, James A Brannigan, Joseph Newman, Markus Ritzefeld, Jennie A Hutton, Anabel Guedán, Amin S Asfor, Sean W Robinson, Iva Hopkins-Navratilova, Anthony J Wilkinson, Sebastian L Johnston, Robin J Leatherbarrow, Tobias J Tuthill, Roberto Solari, Edward W Tate
Rhinoviruses (RVs) are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report the discovery of IMP-1088, a picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NMT2, and use it to demonstrate that pharmacological inhibition of host-cell N-myristoylation rapidly and completely prevents rhinoviral replication without inducing cytotoxicity. The identification of cooperative binding between weak-binding fragments led to rapid inhibitor optimization through fragment reconstruction, structure-guided fragment linking and conformational control over linker geometry...
May 14, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29746692/increased-risk-of-upper-respiratory-infection-in-military-recruits-who-report-sleeping-less-than-6-h-per-night
#8
Laurel M Wentz, Mark D Ward, Claire Potter, Samuel J Oliver, Sarah Jackson, Rachel M Izard, Julie P Greeves, Neil P Walsh
Introduction: Professional sleep associations recommend 7-9 h of sleep per night for young adults. Habitually sleeping less than 6 h per night has been shown to increase susceptibility to common cold in otherwise healthy, adult civilians. However, no investigations have examined the importance of sleep duration on upper respiratory tract infection (URTI) and loss of training days in military recruits. The purpose of this study was to describe self-reported sleep duration in a large cohort of military recruits and to assess the relationship between reported sleep duration and incidence of URTI's...
May 9, 2018: Military Medicine
https://www.readbyqxmd.com/read/29746573/self-diagnosis-of-seasonal-influenza-in-a-rural-primary-care-setting-in-japan-a-cross-sectional-observational-study
#9
Hiroki Maita, Tadashi Kobayashi, Hiroshi Osawa, Hiroyuki Kato
OBJECTIVE: To elucidate the accuracy and optimal cut-off point of self-diagnosis and clinical symptoms of seasonal influenza compared with rapid influenza diagnostic tests as the reference standard, we conducted a cross sectional observational study at a rural clinic in Japan. METHODS: Data during three influenza seasons (December 2013 to April 2016) were retrospectively collected from the medical records and pre-examination sheets of 111 patients aged >11 years (mean age 48...
2018: PloS One
https://www.readbyqxmd.com/read/29718842/eunkyosan-for-treatment-of-the-common-cold-a-protocol-for-the-systematic-review-of-controlled-trials
#10
Hesol Lee, Bohyung Kang, Jun-Yong Choi, Sunju Park, Myeong Soo Lee, Ju Ah Lee
INTRODUCTION: Eunkyosan (EKS) is widely used for common colds in East Asian countries. Many clinical trials assessing the efficacy and safety of EKS formula for the treatment of common colds have been reported. This review will assess the clinical evidence for and against the use of EKS formula as a treatment for common colds. METHODS AND ANALYSIS: Fourteen databases will be searched from inception until March 2018. We will include randomized controlled trials (RCTs) assessing EKS decoctions for any type of common cold...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29715717/antiviral-and-anti-inflammatory-activities-of-pochonin-d-a-heat-shock-protein-90-inhibitor-against-rhinovirus-infection
#11
Jae-Hyoung Song, Aeri Shim, Yeon-Jeong Kim, Jae-Hee Ahn, Bo-Eun Kwon, Thuy Trang Pham, Jongkook Lee, Sun-Young Chang, Hyun-Jeong Ko
Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular chaperone, is an important host factor for the replication of single-strand RNA viruses. In the current study, we examined the effect of the Hsp90 inhibitor pochonin D, in vitro and in vivo , using a murine model of human rhinovirus type 1B (HRV1B) infection. Our data suggested that Hsp90 inhibition significantly reduced the inflammatory cytokine production and lung damage caused by HRV1B infection...
May 2, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29686673/the-cd8-t-cell-response-to-respiratory-virus-infections
#12
REVIEW
Megan E Schmidt, Steven M Varga
Humans are highly susceptible to infection with respiratory viruses including respiratory syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and parainfluenza virus. While some viruses simply cause symptoms of the common cold, many respiratory viruses induce severe bronchiolitis, pneumonia, and even death following infection. Despite the immense clinical burden, the majority of the most common pulmonary viruses lack long-lasting efficacious vaccines. Nearly all current vaccination strategies are designed to elicit broadly neutralizing antibodies, which prevent severe disease following a subsequent infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29672626/engystol-reduces-onset-of-experimental-respiratory-syncytial-virus-induced-respiratory-inflammation-in-mice-by-modulating-macrophage-phagocytic-capacity
#13
Sabine Wronski, Julia Dannenmaier, Sabine Schild, Olaf Macke, Laura Müller, Yvonne Burmeister, Bernd Seilheimer, Meike Müller
BACKGROUND: Respiratory viruses such as respiratory syncytial virus (RSV) or rhinovirus are one of the major causes for respiratory tract infections causing common cold disease. Respiratory viral infections range from mild symptoms in adults to serious illness especially in the very young or elderly as well as patients suffering from lung diseases or being immunocompromised due to other reasons. Engystol (EGY-2) is a multicomponent, multitarget preparation consisting of Vincetoxicum hirundinaria and Sulfur in various dilutions...
2018: PloS One
https://www.readbyqxmd.com/read/29659118/risk-of-stroke-associated-with-use-of-nonsteroidal-anti-inflammatory-drugs-during-acute-respiratory-infection-episode
#14
Yao-Chun Wen, Fei-Yuan Hsiao, Zhen-Fang Lin, Cheng-Chung Fang, Li-Jiuan Shen
BACKGROUND: Previous studies suggested that acute respiratory infection (ARI) could trigger stroke and that use of nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with increased risk of stroke. In many countries, NSAIDs have been widely used among patients with ARI or common cold for pain and fever relief. However, studies evaluating whether NSAIDs use during ARI episodes may further increase the risk of stroke were very limited. METHODS AND RESULTS: During 2007 to 2011, 29 518 patients with an incident hospitalization of stroke were identified...
April 16, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29652899/self-care-for-common-colds-a-european-multicenter-survey-on-the-role-of-subjective-discomfort-and-knowledge-about-the-self-limited-course-the-coco-study
#15
Anika Thielmann, Biljana Gerasimovska-Kitanovska, Tuomas H Koskela, Vildan Mevsim, Birgitta Weltermann
INTRODUCTION: Common colds are the most frequently encountered disease worldwide and the most frequent reason for self-care. According to the cross-sectional European Common Colds study (COCO), patients use as many as 12 items on average for self-care. Little is known about the influence of discomfort and knowledge on self-care for common colds. MAIN OBJECTIVE: To understand the influence of patients' discomfort during a cold and their knowledge about the self-limited disease course on the use of self-care measures...
2018: PloS One
https://www.readbyqxmd.com/read/29620719/preoperative-illnesses-in-children-do-not-increase-the-risk-of-complications-after-hypospadias-repair
#16
Elisabeth Mj Dokter, Karen Ma Slikboer, Loes Fm van der Zanden, Janette C Rahamat-Langendoen, Stefanie Sv Henriet, Wout Fj Feitz, Barbara Bm Kortmann, Nel Roeleveld, Iris Alm van Rooij
BACKGROUND: Preoperative illnesses might induce immunosuppression and subsequently increase morbidity after surgery. Several studies have tried to identify risk factors for complications after hypospadias correction, but effects of illnesses in the weeks just before surgery are unknown. We aimed to determine the associations between preoperative illnesses not severe enough to postpone surgery and short-term complications after hypospadias repair in children. METHODS: In this retrospective cohort study, data were collected from 681 children with anterior or middle type hypospadias that had initial one-stage repair in the period 1983-2012 in the Radboudumc, The Netherlands...
March 31, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29619598/pcr-array-profiling-of-antiviral-genes-in-human-embryonic-kidney-cells-expressing-human-coronavirus-oc43-structural-and-accessory-proteins
#17
Meshal Beidas, Wassim Chehadeh
Human coronavirus OC43 (HCoV-OC43) is a respiratory virus that usually causes a common cold. However, it has the potential to cause severe infection in young children and immunocompromised adults. Both SARS-CoV and MERS-CoV were shown to express proteins with the potential to evade early innate immune responses. However, the ability of HCoV-OC43 to antagonise the intracellular antiviral defences has not yet been investigated. The potential role of the HCoV-OC43 structural (M and N) and accessory proteins (ns2a and ns5a) in the alteration of antiviral gene expression was investigated in this study...
April 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29611024/anticancer-effect-of-fermented-insampaedok-san-in-human-colon-cancer-cells-a-pilot-study
#18
Hwayong Park, Kwang Dong Kim
Insampaedok-san (IPS) is one of the East Asian traditional medicines which have been prescribed for hundreds of years to treat common cold and headache. Although many herbs and prescriptions are known to have significant activities against diseases, only a limited number of reports and scientific evidences on their efficacies are available. To identify anticancer effect against colon cancer, traditional prescription IPS and its fermented IPS (FIPS) were examined by in vitro molecular biological analysis. IPS water extract was fermented, lyophilized, and examined by cytotoxicity, cell cycle, and western blot assays, using cancer cell lines...
April 2, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29610730/comparison-of-the-efficacy-of-dispensing-granules-with-traditional-decoction-a-systematic-review-and-meta-analysis
#19
Ruijin Qiu, Xiaoyu Zhang, Chen Zhao, Min Li, Hongcai Shang
Background: Dispensing granules have been developed for about 20 years. However, whether they are as effective as the traditional decoction kept unclear. This systematic review and meta-analysis was made to assess the efficacy of dispensing granules compared with traditional decoction. Methods: We searched four databases since their inception to 9th September in 2016. Two authors independently identified trials, extracted data and assessed risk of bias with Cochrane Reviewer's Handbook 5...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29593018/randomised-controlled-trial-of-rhinothermy-for-treatment-of-the-common-cold-a-feasibility-study
#20
Susanne van de Hei, Steven McKinstry, George Bardsley, Mark Weatherall, Richard Beasley, James Fingleton
OBJECTIVE: To determine the feasibility of a randomised controlled trial (RCT) of rhinothermy for the common cold. DESIGN: Open label, randomised, controlled feasibility study. SETTING: Single-centre research institute in New Zealand recruiting participants from the community. PARTICIPANTS: 30 adult participants with symptoms of a common cold, presenting within 48 hours of the onset of symptoms. INTERVENTIONS: Participants were randomly assigned 2:1 to receive either 35 L/min of 100% humidified air at 41°C via high flow nasal cannulae, 2 hours per day for up to 5 days (rhinothermy), or vitamin C 250 mg daily for 5 days (control)...
March 27, 2018: BMJ Open
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