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https://www.readbyqxmd.com/read/28714040/perspectives-of-pharmacy-staff-on-dispensing-subtherapeutic-doses-of-antibiotics-a-theory-informed-qualitative-study
#1
Mohamed Ezzat Khamis Amin, Amira Amine, Mohammad Shoukry Newegy
Background Injudicious dispensing of antibiotics in subtherapeutic doses is common in many developing countries. In Egypt, as in many developing countries, a few pills of common cold products are offered under the name cold group (CG). A cold group may contain one or more pills of antibiotics. A pharmacy client may obtain subtherapeutic doses of antibiotics upon direct request or as part of a CG. Objective To examine factors associated with the unwarranted dispensing of subtherapeutic doses of antibiotics in community pharmacies as part of a CG or upon direct request from patients among community pharmacy staff...
July 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28712182/trend-of-irrational-medication-among-the-students-of-department-of-pharmacy-abbottabad-university-of-science-and-technology-in-common-cold-and-flu
#2
Mujeeb Ur Rehman, Saif Ullah Mehsud, Sartaj Ali, Muhammad Ishaq, Mumtaz Ali Khan
BACKGROUND: Common cold and flu are mostly of viral pathogenesis with symptoms in upper respiratory tract. It is highly contagious and close inter-individual contact in winter season increase the spread spectrum. Mis-interpretation with bacterial cause leads to irrationality in its medication. METHODS: A cross-sectional study was conducted among pharmacy department students in February-March 2016. Data were collected through self-administered questionnaire and expressed as percentage frequency...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28705625/antiviral-activity-of-gemcitabine-against-human-rhinovirus-in%C3%A2-vitro-and-in%C3%A2-vivo
#3
Jae-Hyoung Song, Seong-Ryeol Kim, Eun-Young Heo, Jae-Young Lee, Dong-Eun Kim, Sungchan Cho, Sun-Young Chang, Byung-Il Yoon, Jeongmin Seong, Hyun-Jeong Ko
Rhinovirus, a major causative agent of the common cold, is associated with exacerbation of asthma and chronic obstructive pulmonary disease. Currently, there is no antiviral treatment or vaccine for human rhinovirus (HRV). Gemcitabine (2',2'-difluorodeoxycytidine, dFdC) is a deoxycytidine analog with antiviral activity against rhinovirus, as well as enterovirus 71, in vitro. However, the antiviral effects of gemcitabine in vivo have not been investigated. In the current study, we assessed whether gemcitabine mediated antiviral effects in the murine HRV infection model...
July 11, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28700631/is-the-level-of-knowledge-a-predictor-of-rational-antibiotic-use-in-serbia
#4
Olga J Horvat, Ana D Tomas, Milica M Paut Kusturica, Alisa V Savkov, Dragica U Bukumirić, Zdenko S Tomić, Ana J Sabo
INTRODUCTION: The objective of this study was to investigate the knowledge, attitudes and behavior regarding antibiotics of the general population. METHODS: The study sample consisted of adult subjects who consulted general practitioners at health centers in Serbia and agreed to complete the questionnaire. A total of 668 questionnaires were distributed; 500 respondents completed the entire questionnaire (response rate 74.85%). RESULTS: The average age was 51...
2017: PloS One
https://www.readbyqxmd.com/read/28696310/antibody-induced-uncoating-of-human-rhinovirus-b14
#5
Yangchao Dong, Yue Liu, Wen Jiang, Thomas J Smith, Zhikai Xu, Michael G Rossmann
Rhinoviruses (RVs) are the major causes of common colds in humans. They have a nonenveloped, icosahedral capsid surrounding a positive-strand RNA genome. Here we report that the antigen-binding (Fab) fragment of a neutralizing antibody (C5) can trigger genome release from RV-B14 to form emptied particles and neutralize virus infection. Using cryo-electron microscopy, structures of the C5 Fab in complex with the full and emptied particles have been determined at 2.3 Å and 3.0 Å resolution, respectively. Each of the 60 Fab molecules binds primarily to a region on viral protein 3 (VP3)...
July 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28692318/misconceptions-and-malpractices-toward-antibiotic-use-in-childhood-upper-respiratory-tract-infections-among-a-cohort-of-lebanese-parents
#6
Ghada El Khoury, Elsy Ramia, Pascale Salameh
Antimicrobial resistance is an emerging global health threat. Misuse and abuse of antibiotics are of particular concern in the pediatric population. Since management of childhood illnesses depends considerably on parents' perceptions, the objectives of this study were to report parents' perspectives and assess their practices toward antibiotics used for upper respiratory tract infections (URTIs) in children. Using a cross-sectional design, anonymous structured questionnaires were completed by 1,037 parents in public and private schools across Lebanon's largest governorate...
January 1, 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/28677358/epidemiology-of-chronic-urticaria-in-korea-using-the-korean-health-insurance-database-2010-2014
#7
Nami Lee, Jeong Dong Lee, Hyun Young Lee, Dae Ryong Kang, Young Min Ye
PURPOSE: There are very few epidemiological studies on chronic urticaria (CU). We aimed to investigate the prevalence of CU and to depict demographics and medication patterns for the disease in a nationwide population-based study. METHODS: Data on urticaria (L50 of the International Classification of Diseases, 10th revision) from 2010 to 2014 were obtained from the Korean Health Insurance Review and Assessment Service. Algorithms designed to evaluate prescription drug claims for antihistamines were applied to identify CU...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28676946/variability-of-breath-condensate-ph-may-contribute-to-the-better-understanding-of-non-allergic-seasonal-respiratory-diseases
#8
Tamás Kullmann, Annamária Szipőcs
The seasonal variability of certain non-allergic respiratory diseases is not clearly understood. Analysis of the breath condensate, the liquid that can be collected by breathing into a cold tube, has been proposed to bring closer to the understanding of airway pathologies. It has been assumed, that (1) airway lining fluid was a stable body liquid and (2) the breath condensate samples were representative of the airway lining fluid. Research was focussed on the identification of biomarkers indicative of respiratory pathologies...
July 5, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28674113/probiotics-and-child-care-absence-due-to-infections-a-randomized-controlled-trial
#9
Rikke Pilmann Laursen, Anni Larnkjær, Christian Ritz, Hanne Hauger, Kim Fleischer Michaelsen, Christian Mølgaard
OBJECTIVES: The risk of infections is higher in children attending child care compared with children cared for at home. This study examined the effect of a combination of probiotics on absence from child care because of respiratory and gastrointestinal infections in healthy infants aged 8 to 14 months at the time of enrollment in child care. METHODS: The ProbiComp study was a randomized, double-blind, placebo-controlled study. A total of 290 infants were randomly allocated to receive a placebo or a combination of Bifidobacterium animalis subsp lactis and Lactobacillus rhamnosus in a dose of 10(9) colony-forming units of each daily for a 6-month intervention period...
July 3, 2017: Pediatrics
https://www.readbyqxmd.com/read/28660744/reconceptualizing-mental-disorders-from-symptoms-to-organs
#10
Mario Bunge
Most mental pathologies are diagnosed on the sole basis of the symptoms reported by patients, such as "I'm feeling low." The thrust of this paper is the proposal to reconceptualize mental disorders as dysfunctions of brain subsystems. This shift from symptom to organ would bring psychiatry in line with the rest of medicine, and is analogous to the change in status of venereal infections from skin pathologies, such as chancres, to bacterial infections. The proposal in question is part of the reconceptualization of mental processes as brain processes, in line with the materialist conception of the mind as neural...
June 2017: PsyCh Journal
https://www.readbyqxmd.com/read/28651289/a-validated-method-for-the-quality-control-of-andrographis-paniculata-preparations
#11
Anastasia Karioti, Patricia Timoteo, Maria Camilla Bergonzi, Anna Rita Bilia
Andrographis paniculata is a herbal drug of Asian traditional medicine largely employed for the treatment of several diseases. Recently, it has been introduced in Europe for the prophylactic and symptomatic treatment of common cold and as an ingredient of dietary supplements. The active principles are diterpenes with andrographolide as the main representative. In the present study, an analytical protocol was developed for the determination of the main constituents in the herb and preparations of A. paniculata...
June 26, 2017: Planta Medica
https://www.readbyqxmd.com/read/28646961/rhinovirus-not-just-the-common-cold
#12
Simon B Drysdale, Asuncion Mejias, Octavio Ramilo
Rhinoviruses (RV) are ubiquitous respiratory tract pathogens. They affect both the upper and lower respiratory tract and cause colds but have also been associated with wheezing, asthma exacerbations and pneumonia. New blood transcription profiling techniques of the host immune response are becoming available to characterise the pathogenesis of RV in humans. This review will outline the clinical impact of RVs in children.
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28643722/endogenous-endophthalmitis-caused-by-cryptococcus-neoformans-var-gattii-mimicking-choroidal-tumor-from-positron-emission-tomography-computed-tomography-to-histopathology
#13
Chun-Ju Lin, Wen-Lu Chen, Jane-Ming Lin, Peng-Tai Tien, Yi-Yu Tsai
A 60-year-old immunocompetent female with pneumonia history about 10 years ago suffered from blurred vision overall survival for 3 weeks. Common cold with headache and unintentional body weight loss was also noted recently. Choroidal detachment simulating choroidal tumor was observed in the temporal quadrant. The 18F-fluoro-2-deoxyglucose (FDG) positron-emission tomography/computed tomography (CT) scan showed focal, mild to moderate FDG uptake in the left lateral orbit, and an enhanced lesion was seen on the recent CT scan...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28612694/-anticholinergic-syndrome-caused-by-contaminated-herbal-tea-acting-swiftly-to-identify-the-source
#14
C Oerlemans, I de Vries, A J H P van Riel
BACKGROUND: Despite good manufacturing practice and quality control, consumer products can become contaminated. In some cases, this can result in severe and life-threatening intoxication with potentially fatal consequences. CASE DESCRIPTION: A 27-year-old man and a 28-year-old pregnant woman presented to the Emergency Department with severe anticholinergic syndrome after using a marshmallow root (Althaea officinalis) herbal remedy, mixed into hot chocolate drink, to reduce symptoms of common cold...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28606988/recurrent-rhinovirus-infections-in-a-child-with-inherited-mda5-deficiency
#15
Ian T Lamborn, Huie Jing, Yu Zhang, Scott B Drutman, Jordan K Abbott, Shirin Munir, Sangeeta Bade, Heardley M Murdock, Celia P Santos, Linda G Brock, Evan Masutani, Emmanuel Y Fordjour, Joshua J McElwee, Jason D Hughes, Dave P Nichols, Aziz Belkadi, Andrew J Oler, Corinne S Happel, Helen F Matthews, Laurent Abel, Peter L Collins, Kanta Subbarao, Erwin W Gelfand, Michael J Ciancanelli, Jean-Laurent Casanova, Helen C Su
MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts and intermediates. We studied a child with life-threatening, recurrent respiratory tract infections, caused by viruses including human rhinovirus (HRV), influenza virus, and respiratory syncytial virus (RSV). We identified in her a homozygous missense mutation in IFIH1 that encodes MDA5. Mutant MDA5 was expressed but did not recognize the synthetic MDA5 agonist/(ds)RNA mimic polyinosinic-polycytidylic acid. When overexpressed, mutant MDA5 failed to drive luciferase activity from the IFNB1 promoter or promoters containing ISRE or NF-κB sequence motifs...
July 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28599066/rhinovirus-and-pre-school-wheeze
#16
REVIEW
Katarina Stenberg-Hammar, Gunilla Hedlin, Cilla Söderhäll
Rhinovirus (RV) known as the common cold virus generally only causes a mild upper respiratory infection, but severe lower respiratory symptoms have been associated with RV infections especially in asthmatic individuals. Wheezing is a symptom of airway obstruction, and preschool children wheezing with RV have been associated with increased risk of asthma at school age. There are however conflicting opinions as to whether there are differences in response to RV infection or if wheezing with RV reveals a preexisting impairment that promotes asthma mainly in predisposed children...
June 9, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28584098/offspring-of-parents-who-were-separated-and-not-speaking-to-one-another-have-reduced-resistance-to-the-common-cold-as-adults
#17
Michael L M Murphy, Sheldon Cohen, Denise Janicki-Deverts, William J Doyle
Exposure to parental separation or divorce during childhood has been associated with an increased risk for physical morbidity during adulthood. Here we tested the hypothesis that this association is primarily attributable to separated parents who do not communicate with each other. We also examined whether early exposure to separated parents in conflict is associated with greater viral-induced inflammatory response in adulthood and in turn with increased susceptibility to viral-induced upper respiratory disease...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28581749/a-novel-series-of-highly-potent-small-molecule-inhibitors-of-rhinovirus-replication
#18
Jinwoo Kim, Yu Kyoung Jung, Chonsaeng Kim, Jin Soo Shin, Els Scheers, Joo-Youn Lee, Soo Bong Han, Chong-Kyo Lee, Johan Neyts, Jae-Du Ha, Young-Sik Jung
Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current investigation, we developed a novel series of benzothiophene derivatives and their analogues (6-8) that potently inhibit the replication of both hRV-A and hRV-B strains. Compound 6g inhibited the replication of hRV-B14, A21, and A71, with respective EC50 values of 0...
June 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28565899/post-infectious-persistent-cough-pathogenesis-and-therapeutic-options
#19
Carlo Capristo, Giovanni A Rossi
Post-infectious cough is a common symptom associated with common colds and/or upper respiratory tract infection. This cough is expected to last for only for few days and resolve spontaneously, whilst when persists for longer than three weeks is defined "persistent" and is associated tickling or an irritating sensation in the throat which often leads to paroxysms of coughing. Persistent post-infectious cough can cause morbidity since it may interfere with usual living. Despite the recent advances in understanding the mechanisms that regulate cough, in physiological and pathological conditions, current therapeutic options for post-infectious cough are little or only moderately effective...
May 31, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28540002/mewds-common-cold-of-the-retina
#20
EDITORIAL
Ali Tavallali, Lawrence A Yannuzzi
No abstract text is available yet for this article.
April 2017: Journal of Ophthalmic & Vision Research
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