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https://www.readbyqxmd.com/read/27925348/factors-associated-with-efficacy-of-an-ibuprofen-pseudoephedrine-combination-drug-in-pharmacy-customers%C3%A2-with-common-cold-symptoms
#1
Ludger Klimek, Helmut Schumacher, Tanja Schütt, Heidemarie Gräter, Tobias Mueck, Martin C Michel
AIM: The aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over-the-counter ibuprofen/pseudoephedrine combination product. METHODS: Data from an anonymous survey among 1770 pharmacy customers purchasing the combination product for treatment of own common cold symptoms underwent post-hoc descriptive analysis. Scores of symptoms typically responsive to ibuprofen (headache, pharyngeal pain, joint pain and fever), typically responsive to pseudoephedrine (congested nose, congested sinus and runny nose), considered non-specific (sneezing, fatigue, dry cough, cough with expectoration) and comprising all 11 symptoms were analysed...
December 7, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27912214/common-cold-an-umbrella-term-for-acute-infections-of-nose-throat-larynx-and-bronchi
#2
P Kardos, F A Malek
Acute respiratory tract infections, i. e. rhinitis, sinusitis, pharyngitis, laryngitis, bronchitis, belong to the most common medical conditions with a high economic burden. Nonetheless, there is little agreement concerning their differential diagnosis.This paper will discuss to what extent different anatomical sites of acute respiratory tract infections can be uniquely identified or whether the overlap and consecutive development in signs and symptoms renders these distinctions meaningless.Acute respiratory tract infections are variable but definition of diagnostic categories based on the anatomical sites of the dominant complaints shows that signs and symptoms both overlap to a great extent and/or emerge successively...
December 2, 2016: Pneumologie
https://www.readbyqxmd.com/read/27912193/comparative-tissue-distribution-and-excretion-study-of-alkaloids-from-herba-ephedrae-radix-aconiti-lateralis-extracts-in-rats
#3
Mengyue Ren, Shuai Song, Dedong Liang, Weiting Hou, Xiaomei Tan, Jiabo Luo
Herba Ephedrae-Radix Aconiti Lateralis, composed of Ephedrae (Mahuang in Chinese) and Radix Aconiti Lateralis (Fuzi in Chinese), is a classical herbal combination proven to be effective in treating common cold, asthma, and rheumatoid arthritis. Alkaloids, bioactive components of the herbal extract, have been associated with many side effects. Nine alkaloids, including norephedrine, norpseudoephedrine, ephedrine, pseudoephedrine, methylephedrine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine, were simultaneously quantified within 14...
November 13, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27902347/the-conserved-n-terminus-of-human-rhinovirus-capsid-protein-vp4-contains-membrane-pore-forming-activity-and-is-a-target-for-neutralising-antibodies
#4
Anusha Panjwani, Amin S Asfor, Tobias J Tuthill
Human rhinovirus is the causative agent of the common cold and belongs to the non-enveloped picornavirus family. A trigger such as receptor binding or low pH initiates conformational changes in the capsid that allow the virus to attach to membranes and form a pore for the translocation of viral RNA into the cytoplasm. We previously showed that recombinant capsid protein VP4 was able to form membrane pores. In this study, we show the N-terminus but not C-terminus of VP4, formed pores with properties similar to full-length VP4 and consistent with the size required for transfer of RNA...
October 11, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27880051/multimorbidities-of-asthma-allergies-and-airway-illnesses-in-childhood-chance-or-not-chance
#5
Wei Liu, Chen Huang, Xueying Wang, Jiao Cai, Yu Hu, Zhijun Zou, Louise B Weschler, Li Shen, Jan Sundell
OBJECTIVES: We investigated patterns of multimorbidities among asthma, allergies, and respiratory illnesses in preschool children. We examined lifetime multimorbidities of asthma, allergic rhinitis, eczema, food allergy, pneumonia, and ear infections; and current (in the last year before the survey) multimorbidities of wheeze, dry cough, rhinitis, eczema, and common cold during childhood. We further analyzed whether prevalences of these multimorbidities were due to chance. METHODS: A cross-sectional study was conducted in 72 kindergartens of Shanghai, China...
November 23, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27878468/the-risk-of-adverse-pregnancy-outcome-after-first-trimester-exposure-to-h1-antihistamines-a-systematic-review-and-meta-analysis
#6
REVIEW
Fatma Etwel, Lauren H Faught, Michael J Rieder, Gideon Koren
INTRODUCTION: H1 antihistamines are used for the treatment of nausea and vomiting during pregnancy as well as the symptomatic relief of asthma, urticaria, allergy, and the common cold. Although they are overall felt to be safe during pregnancy, recently several studies have challenged this assumption, as millions of women are exposed to them in the first trimester. METHODS: Following the guidelines of PRISMA, a systematic review was performed to retrieve all published articles involving H1-antihistamine exposure during pregnancy...
November 22, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27833115/transcriptome-assists-prognosis-of-disease-severity-in-respiratory-syncytial-virus-infected-infants
#7
Victor L Jong, Inge M L Ahout, Henk-Jan van den Ham, Jop Jans, Fatiha Zaaraoui-Boutahar, Aldert Zomer, Elles Simonetti, Maarten A Bijl, H Kim Brand, Wilfred F J van IJcken, Marien I de Jonge, Pieter L Fraaij, Ronald de Groot, Albert D M E Osterhaus, Marinus J Eijkemans, Gerben Ferwerda, Arno C Andeweg
Respiratory syncytial virus (RSV) causes infections that range from common cold to severe lower respiratory tract infection requiring high-level medical care. Prediction of the course of disease in individual patients remains challenging at the first visit to the pediatric wards and RSV infections may rapidly progress to severe disease. In this study we investigate whether there exists a genomic signature that can accurately predict the course of RSV. We used early blood microarray transcriptome profiles from 39 hospitalized infants that were followed until recovery and of which the level of disease severity was determined retrospectively...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27812536/rasch-analysis-of-the-wurss-21-dimensional-validation-and-assessment-of-invariance
#8
Roger L Brown, Chidi N Obasi, Bruce Barrett
BACKGROUND: The purpose of this study is to use Rasch analysis to explore the validity of considering self-report scores from Wisconsin Upper Respiratory Symptom Survey (WURSS-21) as a single global illness severity domain. The WURSS-21 is a widely used questionnaire instrument that assesses symptom severity and functional impact of common cold and flu-like illness. METHODS: This study applies item response theory, specifically Rasch modeling, to investigate dimensional and measurement properties of the WURSS-21, and looks at invariance over time...
2016: Journal of Lung, Pulmonary & Respiratory Research
https://www.readbyqxmd.com/read/27799071/evaluation-of-coldzyme%C3%A2-mouth-spray-on-prevention-of-upper-respiratory-tract-infections-in-a-boy-with-primary-immunodeficiency-a-case-report
#9
Mats Clarsund, Ulf Blom, Ann Gardulf
BACKGROUND: Primary immunodeficiencies include a variety of disorders that render patients more susceptible to infections. If left untreated, these infections may be fatal. Patients with primary antibody deficiencies are therefore given prophylactic immunoglobulin G replacement therapy. ColdZyme® Mouth Spray is a medical device intended to reduce the probability of catching a cold and/or can help shorten the duration of a cold, if used at an early stage of the infection, by forming a thin protective barrier on the pharyngeal mucous membrane...
October 31, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27762483/range-shifts-or-extinction-ancient-dna-and-distribution-modelling-reveal-past-and-future-responses-to-climate-warming-in-cold-adapted-birds
#10
Vendela K Lagerholm, Edson Sandoval-Castellanos, Amélie Vaniscotte, Olga R Potapova, Teresa Tomek, Zbigniew M Bochenski, Paul Shepherd, Nick Barton, Marie-Claire Van Dyck, Rebecca Miller, Jacob Höglund, Nigel G Yoccoz, Love Dalén, John R Stewart
Global warming is predicted to cause substantial habitat rearrangements, with the most severe effects expected to occur in high-latitude biomes. However, one major uncertainty is whether species will be able to shift their ranges to keep pace with climate-driven environmental changes. Many recent studies on mammals have shown that past range contractions have been associated with local extinctions rather than survival by habitat tracking. Here, we have used an interdisciplinary approach that combines ancient DNA techniques, coalescent simulations and species distribution modelling, to investigate how two common cold-adapted bird species, willow and rock ptarmigan (Lagopus lagopus and Lagopus muta), respond to long-term climate warming...
October 20, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27749661/a-four-year-study-on-epidemiologic-and-molecular-characteristics-of-human-parechoviruses-and-enteroviruses-circulating-in-children-younger-than-5-years-in-northern-italy
#11
Laura Bubba, Marianna Martinelli, Laura Pellegrinelli, Valeria Primache, Elisabetta Tanzi, Elena Pariani, Sandro Binda
BACKGROUND: Human parechovirus (HPeV) and enterovirus (EV) infections are widespread and can lead to a broad range of symptoms, from the common cold to severe disease. Due to the lack of Italian data, this 4-year retrospective cross-sectional study aimed to investigate the frequency, seasonality and molecular characteristics of EV and HPeV circulating in children younger than 5 years. METHODS: 812 samples were collected from children ≤5 years (56.5% males; median age: 20...
September 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27748955/nasal-decongestants-in-monotherapy-for-the-common-cold
#12
REVIEW
Laura Deckx, An Im De Sutter, Linda Guo, Nabiel A Mir, Mieke L van Driel
BACKGROUND: Many treatments for the common cold exist and are sold over-the-counter. Nevertheless, evidence on the effectiveness and safety of nasal decongestants is limited. OBJECTIVES: To assess the efficacy, and short- and long-term safety, of nasal decongestants used in monotherapy to alleviate symptoms of the common cold in adults and children. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 6, June 2016), which contains the Cochrane Acute Respiratory Infections (ARI) Specialised Register, MEDLINE (1946 to July 2016), Embase (2010 to 15 July 2016), CINAHL (1981 to 15 July 2016), LILACS (1982 to July 2016), Web of Science (1955 to July 2016) and clinical trials registers...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27746280/utility-estimation-for-pediatric-vesicoureteral-reflux-methodological-considerations-using-an-online-survey-platform
#13
Rohit Tejwani, Hsin-Hsiao S Wang, Jessica C Lloyd, Paul J Kokorowski, Caleb P Nelson, Jonathan C Routh
BACKGROUND: The advent of online task-distribution has opened a new avenue to efficiently gather community perspectives needed for utility estimation. Methodological consensus for estimating pediatric utilities is lacking, with disagreement over whom to sample, what perspective (patient vs. parent), and whether instrument-induced anchoring bias is significant. We sought to determine what methodological factors potentially impact utility estimates for vesicoureteral reflux (VUR). DESIGN: Cross-sectional surveys using a time-trade-off (TTO) instrument were conducted via Amazon's Mechanical Turk online interface; respondents were randomized to answer questions from child, parent, or dyad perspectives on the utility of a VUR health state and one of three "warm-up" scenarios (paralysis, common cold, none) prior to a VUR scenario...
October 13, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27741312/aqueous-extract-of-gumiganghwal-tang-a-traditional-herbal-medicine-reduces-pulmonary-fibrosis-by-transforming-growth-factor-%C3%AE-1-smad-signaling-pathway-in-murine-model-of-chronic-asthma
#14
Woo-Young Jeon, In-Sik Shin, Hyeun-Kyoo Shin, Seong Eun Jin, Mee-Young Lee
Gumiganghwal-tang is a traditional herbal prescription that is used widely for the treatment of the common cold and inflammatory diseases in Korea and other Asian countries. In this study, we investigated the protective effects of a Gumiganghwal-tang aqueous extract (GGTA) against airway inflammation and pulmonary fibrosis using a mouse model of chronic asthma. Chronic asthma was modeled in BALB/c mice via sensitization/challenge with an intraperitoneal injection of 1% ovalbumin (OVA) and inhalation of nebulized 1% OVA for 4 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27738443/self-care-for-common-colds-by-primary-care-patients-a-european-multicenter-survey-on-the-prevalence-and-patterns-of-practices-the-coco-study
#15
Anika Thielmann, Biljana Gerasimovska-Kitanovska, Krzysztof Buczkowski, Tuomas H Koskela, Vildan Mevsim, Slawomir Czachowski, Ferdinando Petrazzuoli, Marija Petek-Šter, Heidrun Lingner, Robert D Hoffman, Selda Tekiner, Juliette Chambe, Tamer Edirne, Kathryn Hoffmann, Enzo Pirrotta, Ayşegül Uludağ, Hülya Yikilkan, Sanda Kreitmayer Pestic, Andrzej Zielinski, Clara Guede Fernández, Birgitta Weltermann
Background. Patients use self-care to relieve symptoms of common colds, yet little is known about the prevalence and patterns across Europe. Methods/Design. In a cross-sectional study 27 primary care practices from 14 countries distributed 120 questionnaires to consecutive patients (≥18 years, any reason for consultation). A 27-item questionnaire asked for patients' self-care for their last common cold. Results. 3,074 patients from 27 European sites participated. Their mean age was 46.7 years, and 62.5% were females...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27733646/clinical-isolates-of-human-coronavirus-229e-bypass-the-endosome-for-cell-entry
#16
Kazuya Shirato, Kazuhiko Kanou, Miyuki Kawase, Shutoku Matsuyama
: Human coronavirus 229E (HCoV-229E), a causative agent of the common cold, enters host cells via two distinct pathways: one is mediated by cell surface proteases, particularly transmembrane protease serine 2 (TMPRSS2), and the other by endosomal cathepsin L. Thus, specific inhibitors of these proteases block virus infection. However, it is unclear which of these pathways is actually utilized by HCoV-229E in the human respiratory tract. Here, we examined the mechanism of cell entry used by a pseudotyped virus bearing the HCoV-229E spike (S) protein in the presence/absence of protease inhibitors...
October 12, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27733198/gyeji-tang-water-extract-exerts-anti-inflammatory-activity-through-inhibition-of-erk-and-nf-%C3%AE%C2%BAb-pathways-in-lipopolysaccharide-stimulated-raw-264-7-cells
#17
Sae-Rom Yoo, Yeji Kim, Mee-Young Lee, Ohn-Soon Kim, Chang-Seob Seo, Hyeun-Kyoo Shin, Soo-Jin Jeong
BACKGROUND: Gyeji-tang (GJT, Guizhi Tang in Chinese, Keishi-to in Japanese) is a traditional herbal decoction composed of 5 medicinal herbs. GJT has been used to treat the common cold, headaches, and fever in Asian countries including Korea, China, and Japan. In the present study, we investigated the inhibitory effect of a water extract of GJT on inflammatory response using the murine macrophage cell line, RAW 264.7. METHODS: RAW 264.7 macrophages were treated with lipopolysaccharide (LPS) to upregulate inflammatory genes...
October 12, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27702690/andrographis-paniculata-dissolution-investigation-and-pharmacokinetic-studies-of-four-major-active-diterpenoids-after-multiple-oral-dose-administration-in-healthy-thai-volunteers
#18
Nanthanit Pholphana, Duangchit Panomvana, Nuchanart Rangkadilok, Tawit Suriyo, Porranee Puranajoti, Teerapat Ungtrakul, Wanwisa Pongpun, Saichit Thaeopattha, Phanit Songvut, Jutamaad Satayavivad
ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata is included in 'The National List of Essential Herbal Drugs A.D. 1999' of Thailand as an herbal drug for the treatment of common cold symptoms and non-infectious diarrhea. The therapeutic activities of A. paniculata are attributed to four major active diterpenoids: andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4). However, the pharmacokinetic studies in humans of this plant were performed after a single oral dose administration and reported the parameters related to be of only 1...
October 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27684066/household-knowledge-of-antimicrobials-and-antimicrobial-resistance-in-the-wake-of-an-accredited-drug-dispensing-outlet-addo-program-rollout-in-tanzania
#19
Daudi Simba, Deodatus Kakoko, Innocent Semali, Anna Kessy, Martha Embrey
INTRODUCTION: Private sector drug shops are an important source of medicines in Tanzania. In 2003, the government introduced the accredited drug dispensing outlet (ADDO) program to improve access to good-quality medicines in rural and peri-urban areas that have frequent drug shortages in public health facilities and few or no registered pharmacies. However, increasing access may also contribute to antimicrobial resistance (AMR) due to the potential overuse and misuse of drugs. METHODS: We conducted a cross-sectional household survey in four regions in mainland Tanzaniato characterize consumer care-seeking habits and medicines use and to determine the extent to which members of the community are knowledgeable about antimicrobials and AMR...
2016: PloS One
https://www.readbyqxmd.com/read/27662264/pharmacokinetics-of-guaifenesin-pseudoephedrine-and-hydrocodone-in-a-combination-oral-liquid-formulation-administered-as-single-and-multiple-doses-in-healthy-chinese-volunteers-and-comparison-with-data-for-individual-compounds-formulated-as-antuss-%C3%A2
#20
Shuhua Deng, Wencan Huang, Xiaojia Ni, Ming Zhang, Haoyang Lu, Zhanzhang Wang, Jinqing Hu, Xiuqing Zhu, Chang Qiu, Dewei Shang, Yuefeng Zhang, Linghui Xiong, Yuguan Wen
1. A new oral liquid formulation combining guaifenesin, pseudoephedrine and hydrocodone is effective in improving the symptoms of common cold. The pharmacokinetic properties of the individual components were evaluated in a randomized, open-label, 4-period study in 12 healthy Chinese volunteers following single and multiple doses. The data were compared with data for the individual ingredients in Antuss(®). 2. In the single-dose period, exposure levels (AUC and Cmax) for guaifenesin, pseudoephedrine and hydrocodone increased directly as the dose of the oral liquid formulation increased from 5 to 15 mL...
September 23, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
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