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Amy C Justice, Kirsha S Gordon, Melissa Skanderson, Eva Jennifer Edelman, Kathleen M Akgün, Cynthia L Gibert, Vincent Lo Re, David Rimland, Julie A Womack, Christina M Wyatt, Janet P Tate
BACKGROUND: HIV-positive individuals (HIV+) on antiretrovirals commonly take enough other medications to cross a threshold for polypharmacy but little is known about associated outcomes. We asked whether non-antiretroviral polypharmacy is associated with hospitalization and mortality and whether associations differ by HIV status. METHODS: Data on HIV+ and uninfected individuals in the US Veterans Affairs Healthcare System were analyzed. Eligible HIV+ were on antiretrovirals with suppressed HIV-1 RNA and uninfected individuals received at least one medication...
March 27, 2018: AIDS
Erika Virmani, Julian M Rotter, Andre Mähringer, Tobias von Zons, Adelheid Godt, Thomas Bein, Stefan Wuttke, Dana D Medina
Controlled on-surface film growth of porous and crystalline frameworks is a central requisite for incorporating these materials into functional platforms and operational devices. Here, we present the synthesis of thin zirconium-based metal-organic framework (MOF) films by vapor-assisted conversion (VAC). We established protocols adequate for the growth of UiO-66, UiO-66(NH2 ), UiO-67, and UiO-68(NH2 ) as well as the porous interpenetrated Zr-organic framework (PPPP-PIZOF-1) as highly oriented thin films. Through the VAC approach, precursors in a cast solution layer on a bare gold substrate are reacting to form a porous continuous MOF film, oriented along the [111] crystal axis by an exposure to a solvent vapor under elevated temperatures of 100 °C and 3 h reaction times...
March 15, 2018: Journal of the American Chemical Society
Paul J Choi, Joe Iwanaga, R Shane Tubbs, Emre Yilmaz
Owing to its rarity, rhabdomyosarcoma of the head and neck (HNRMS) has seldom been discussed in the literature. As most of the data is based only on the retrospective experiences of tertiary healthcare centers, there are difficulties in formulating a standard treatment protocol. Moreover, the disease is poorly understood at its pathological, genetic, and molecular levels. For instance, 20% of all histological assessment is inaccurate; even an experienced pathologist can confuse rhabdomyosarcoma (RMS) with neuroblastoma, Ewing's sarcoma, and lymphoma...
January 9, 2018: Curēus
Marc R Matthews, Asia N Quan, Alexandra S Weir, Kevin N Foster, Daniel M Caruso
Introduction: Leaving the abdominal cavity open is a well-described and frequently utilized technique in the treatment of severe intra-abdominal sepsis. Irrigation through a negative pressure wound therapy device is a technique employed to assist in the closure of wounds as well as the reduction of bacterial contamination. Furthermore, hypochlorous acid has been found to be safe and effective in microorganismal elimination from extremity wounds. There is no literature regarding the infusion of hypochlorous solution into the abdominal cavity for intra-abdominal sepsis or mucopurulent abscesses or biofilm...
2018: Eplasty
Lauren Rumble, Ali Aulia Ramly, Mu'man Nuryana, Michael P Dunne
Nationally representative research into violence against children is necessary to understand the scale and complexity of such violence and to evaluate prevention efforts. To date, however, most countries do not have adequate data. In 2013, the government of Indonesia conducted a national Violence Against Children Survey (VACS). This was a cross-sectional household survey of male and female 13-to-24- year-olds designed to estimate physical, emotional, and sexual violence prevalence. The target was to interview at least 2580 individuals; but response rates were much lower than anticipated (females = 66...
2018: Child Indicators Research
Cate M Cameron, Patrick J O'Leary, Ali Lakhani, Jodie M Osborne, Luana de Souza, Kristen Hope, Mohammad S Naimi, Hassan Khan, Qazi S Jawad, Sabir Majidi
Violence against children (VAC) is a significant international problem and, in Afghanistan, is particularly complex given the country has suffered armed conflict and extreme poverty for more than 30 years. The aim of this study was to examine the level of knowledge and observation of VAC by community leaders, professional groups, and business owners in three Afghan districts. A survey of community and religious leaders; health, socio-legal, and education professionals; and business owners from Kabul, Jalalabad, and Torkham ( n = 182) was conducted...
March 1, 2018: Journal of Interpersonal Violence
Ester Comellas, Facundo J Bellomo, Iván Rosales, Luis F Del Castillo, Ricardo Sánchez, Pau Turon, Sergio Oller
Endoluminal vacuum-assisted closure (E-VAC) is a promising therapy to treat anastomotic leakages of the oesophagus and bowel which are associated with high morbidity and mortality rates. An open-pore polyurethane foam is introduced into the leakage cavity and connected to a device that applies a suction pressure to accelerate the closure of the defect. Computational analysis of this healing process can advance our understanding of the biomechanical mechanisms at play. To this aim, we use a dual-stage finite-element analysis in which (i) the structural problem addresses the cavity reduction caused by the suction and (ii) a new constitutive formulation models tissue healing via permanent deformations coupled to a stiffness increase...
February 2018: Royal Society Open Science
Xiaohong Li, Wenchao Li, Wuning Mo, Zheng Yang
RATIONALE: Both acute lymphoblastic leukemia (ALL) and Ewing sarcoma (ES) are small round cell tumors, and it is difficult to differential diagnose them because of overlapping clinical, radiographic, histologic, and immunophenotypic features. PATIENT'S CONCERNS: A 5-year-old boy was admitted to our hospital because of pains in his left leg without obvious inducement and lameness worsening with walking over a two 2-month period. DIAGNOSES: Based on the comprehensive analysis of radiography, magnetic resonance imaging (MRI), pathology biopsy and immunohistochemistry, the lesion was confirmed to be ES...
January 2018: Medicine (Baltimore)
Wei Yuan, Xuan Liu, Xiaoshu Zhou, Lei Pei, Yue Zhu
STUDY DESIGN: A retrospective study. OBJECTIVE: To compare the clinical outcomes of continues irrigation suction systems (CISS) or vacuum assisted closure system (VACS) in early deep wound infection (DWI) after thoracolumbar instrumentation. SUMMARY OF BACKGROUND DATA: DWI after thoracolumbar instrumentation is challenging and debridement followed by either CISS or VACS has been proven to be effective. So far which one of the system has more advantages over the other remains unclear...
February 23, 2018: Spine
Tomoki Yoshikawa, Hikaru Fujii, Akiko Okutani, Miho Shibamura, Natsumi Omura, Kazutaka Egawa, Hirofumi Kato, Takuya Inagaki, Shizuko Harada, Souichi Yamada, Shigeru Morikawa, Masayuki Saijo
LC16m8 (m8), a highly attenuated vaccinia virus (VAC) strain, was developed as a smallpox vaccine, and its safety and immunogenicity have been confirmed. Here, we aimed to develop a system that recovers infectious m8 from a bacterial artificial chromosome (BAC) that retains the full-length viral genomic DNA (m8-BAC system). The infectious virus was successfully recovered from a VAC-BAC plasmid, named pLC16m8-BAC. Furthermore, the bacterial replicon-free virus was generated by intramolecular homologous recombination and was successfully recovered from a modified VAC-BAC plasmid, named pLC16m8...
2018: PloS One
Jamal N Shillingford, Joseph L Laratta, Nana O Sarpong, Hasani Swindell, Meghan Cerpa, Ronald A Lehman, Lawrence G Lenke, Charla Fischer
STUDY DESIGN: A retrospective review of the Scoliosis Research Society (SRS) morbidity and mortality (M&M) database. OBJECTIVE: The aim of this study was to investigate visual related complications in spinal deformity patients undergoing spine surgery. SUMMARY OF BACKGROUND DATA: The SRS compiles surgeon-reported complications into an M&M database, tracking postoperative complications including visual loss, neurological deficits, infections, and death...
February 16, 2018: Spine
Ivano Bonadei, Edoardo Sciatti, Enrico Vizzardi, Davide Fabbricatore, Mattia Pagnoni, Laura Rossi, Valentina Carubelli, Carlo M Lombardi, Marco Metra
AIM: Heart rate (HR) is an important prognostic factor in patients affected by chronic heart failure (CHF); ivabradine has been demonstrated to significantly reduce nonfatal myocardial infarction and hospitalization rate for acute heart failure and to improve left ventricular (LV) reverse remodelling, quality of life, exercise capacity and arterial elastance (Ea) in these patients. We aimed at evaluating the short-term effects of ivabradine on ventricular-arterial coupling (VAC), aortic stiffness and endothelial function in stable patients with CHF...
February 20, 2018: Cardiovascular Therapeutics
Jian-Ping Wu, Zhen-Huan Jiang, Xiao-Jun Feng, Jian-Nong Jiang, Mao-Hua Cheng
BACKGROUND The aim of this study was to investigate the effects of negative pressure therapy in the regeneration of the rabbit sciatic nerve using vacuum assisted closure (VAC). MATERIAL AND METHODS Thirty male New Zealand white rabbits underwent surgical injury of the sciatic nerve, followed by negative pressure therapy using vacuum assisted closure (VAC), in three treatment groups: Group A: 0 kPa; Group B: -20 kPa; Group C: -40 kPa. At 12 weeks following surgery, the following factors were studied: motor nerve conduction velocity (MNCV); the number of myelinated nerve fibers; the wet weight of the gastrocnemius muscle...
February 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
José Bueno-Lledó, Antonio Torregrosa, Raquel Jiménez, Providencia García Pastor
INTRODUCTION: Preoperative progressive pneumoperitoneum (PPP) and botulinum toxin type A (BT) are tools in the surgical preparation of patients with loss of domain hernias (LODH). The aim of this paper is to report our experience with these preoperative techniques in 70 patients with LODH. METHODS: Observational study of 70 consecutive patients with LODH was conducted between May 2010 and May 2016. Diameters of the hernia sac, incisional hernia (VIH), and abdominal cavity (VAC) volumes, and VIH/VAC ratio were measured before and after PPP and BT, using abdominal CT scan data...
February 15, 2018: Surgical Endoscopy
T Chan, M S Bleszynski, D S Youssef, M Segedi, S Chung, C H Scudamore, A K Buczkowski
INTRODUCTION: Damage control laparotomy with vacuum assisted closure (VAC) is used for selective cases in trauma. In liver transplantation, VAC has also been applied for management of intra-operative hemorrhage. The primary objective was to evaluate peri-operative blood loss and blood product utilization in VAC compared to primary abdominal closure (PAC) at the index transplant operation. METHODS: Retrospective review of all adults undergoing deceased donor liver transplantation (2007-2011) at a single center tertiary care institution...
January 31, 2018: American Journal of Surgery
Olivia L McGovern, Yolanda Rivera-Cuevas, Geetha Kannan, Andrew Narwold, Vern B Carruthers
Host cytosolic proteins are endocytosed by Toxoplasma gondii and degraded in its lysosome-like compartment, the VAC, but the dynamics and route of endocytic trafficking remain undefined. Conserved endocytic components and plant-like features suggest T. gondii endocytic trafficking involves transit through early and late endosome-like compartments (ELCs) and potentially the trans-Golgi network (TGN) as in plants. However, exocytic trafficking to regulated secretory organelles, micronemes and rhoptries, also proceeds through ELCs and requires classical endocytic components including a dynamin-related protein, DrpB...
February 13, 2018: Traffic
Karl Waked, Philippe Ballaux, Dominique Goossens, Koen Cathenis
The objective is to describe the 'Two Bridges Technique' (TBT), which has proven to be successful and has been the standard technique at our centre for vacuum-assisted closure (VAC) of post-sternotomy mediastinitis. An extensive literature search was performed in four databases to identify all published articles concerning VAC for post-sternotomy mediastinitis. Several VAC methods have been used; however, no article has described our specific technique. TBT consists of a two-bridges construction using two types of foam with different pore sizes, which ensures an equally divided negative pressure over the wound bed and stabilisation of the chest...
February 12, 2018: International Wound Journal
Rosa Capita, Tania Álvarez-González, Carlos Alonso-Calleja
A total of 365 ostrich steaks were packaged in air (AIR), vacuum (VAC), MAP1 (70% O2 + 30% CO2), MAP2 (30% O2 + 30% N2 + 40% CO2), MAP3 (20% O2 + 30% N2 + 50% CO2), MAP4 (50% N2 + 50% CO2), MAP5 (20% N2 + 80% CO2) or MAP6 (100% CO2). Microbial counts (10 groups), pH, Aw and sensory properties (nine-point hedonic scale) were determined on days 0, 1, 3, 7 and 15 of storage (4 °C). On day 0, microbial counts (log10 cfu/g) ranged from undetectable levels (Brochothrix thermosphacta, enterococci) to 3...
June 2018: Food Microbiology
Max E Godfrey, Rahul H Rathod, Ellen Keenan, Kimberlee Gauvreau, Andrew J Powell, Tal Geva, Ashwin Prakash
The ventriculoarterial coupling (VAC) ratio, the ratio of arterial elastance (Ea) to ventricular end-systolic elastance (Ees), reflects cardiovascular efficiency. Little is known about this ratio in patients who have undergone the Fontan procedure. Our aim was to assess the VAC ratio in a cohort of Fontan patients using a cardiac magnetic resonance (CMR) method, and to examine its relation to outcomes. We retrospectively assessed VAC from CMR data on 195 Fontan patients (age 19.6 ± 10.7 years) and 42 controls (age 15...
February 5, 2018: Pediatric Cardiology
Muhammad Amin Yousaf, Zain Ul Abidin, Kamran Khalid, Ata Ul Haq, Farrukh Aslam Khalid, Faraz Ahmad Tarar, Muhammad Umar Asif, Moazzam Nazeer Tarar
Obective:To assess the outcome of extended delayed reverse sural artery flap for reconstruction of foot defects proximal to toes in terms of flap survival, complication and extended area. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from February 2015 to April 2017. METHODOLOGY: Cases who underwent delayed sural artery flap were inducted. Preoperative hand-held doppler was done to confirm the location of perforator...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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