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https://www.readbyqxmd.com/read/28515766/pancreatic-protective-and-hypoglycemic-effects-of-vitex-agnus-castus-l-fruit-hydroalcoholic-extract-in-d-galactose-induced-aging-mouse-model
#1
Akram Ahangarpour, Ali Akbar Oroojan, Layasadat Khorsandi, Seyedeh Asma Najimi
D-galactose induces pancreatic disorder along with aging mouse model. Vitex agnus-castus (VAC) has potential pancreatic protective effect. Hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of VAC hydroalcoholic extract in D-galactose-induced aging female mice. In the present experimental study, 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) were divided into 6 groups of control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28503767/the-world-of-epithelial-sheets
#2
REVIEW
Hisao Honda
An epithelium is a layer of closely connected cells covering the body or lining a body cavity. In this review, several fundamental questions are addressed regarding the epithelium. (i) While an epithelium functions as barrier against the external environment, how is barrier function maintained during its construction? (ii) What determines the apical and basal sides of epithelial layer? (iii) Is there any relationship between the apical side of the epithelium and the apical membrane of an epithelial cell? (iv) Why are hepatocytes (liver cells) called epithelial, even though they differ completely from column-like shape of typical epithelial cells? Keeping these questions in mind, multiple shapes of epithelia were considered, extracting a few of their elemental processes, and constructing a virtual world of epithelia by combining them...
May 14, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28501019/towards-a-feminist-understanding-of-intersecting-violence-against-women-and-children-in-the-family
#3
Sophie Namy, Catherine Carlson, Kathleen O'Hara, Janet Nakuti, Paul Bukuluki, Julius Lwanyaaga, Sylvia Namakula, Barbrah Nanyunja, Milton L Wainberg, Dipak Naker, Lori Michau
While intimate partner violence (IPV) against women and violence against children (VAC) have emerged as distinct fields of research and programming, a growing number of studies demonstrate the extent to which these forms of violence overlap in the same households. However, existing knowledge of how and why such co-occurrence takes place is limited, particularly in the Global South. The current study aims to advance empirical and conceptual understanding of intersecting IPV and VAC within families in order to inform potential programming...
April 27, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28492393/long-term-alcohol-use-patterns-and-hiv-disease-severity
#4
Brandon D L Marshall, Janet P Tate, Kathleen A McGinnis, Kendall J Bryant, Robert L Cook, E Jennifer Edelman, Julie R Gaither, Christopher W Kahler, Don Operario, David A Fiellin, Amy C Justice
OBJECTIVE: We examined the relationship between alcohol use trajectories and HIV disease severity among men and women participating in the Veterans Aging Cohort Study (VACS). DESIGN: Prospective cohort of HIV-infected persons in care at eight US Veterans Health Administration sites. METHODS: Between 2002 and 2010, we assessed alcohol consumption annually using the alcohol use disorders identification test-consumption (AUDIT-C). HIV disease severity was ascertained using the VACS index, a validated measure of morbidity and all-cause mortality...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28488072/modified-components-separation-technique-experience-treating-large-complex-ventral-hernias-at-a-university-hospital
#5
A Torregrosa-Gallud, J Sancho Muriel, J Bueno-Lledó, P García Pastor, J Iserte-Hernandez, S Bonafé-Diana, O Carreño-Sáenz, F Carbonell-Tatay
BACKGROUND: An increasing number of patients have large or complex abdominal wall defects. Component separation technique (CST) is a very effective method for reconstructing complex midline abdominal wall defects in a manner that restores innervated muscle function without excessive tension. Our goal is to show our results by a modified CST for treating large ventral hernias. MATERIALS AND METHODS: A total of 351 patients with complex ventral hernias have been treated over a 10-year period...
May 9, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28482229/detecting-dynamic-responses-of-materials-and-devices-under-an-alternating-electric-potential-by-phase-locked-transmission-electron-microscopy
#6
Kentaro Soma, Stan Konings, Ryotaro Aso, Naoto Kamiuchi, Genki Kobayashi, Hideto Yoshida, Seiji Takeda
An apparatus is developed for transmission electron microscopy (TEM) to acquire image and spectral data, such as TEM images, electron holograms, and electron energy loss spectra, synchronized with the measurement of the dynamic response of a specimen under an applied alternating current (AC) electric potential (voltage, denoted VAC). From a VAC of frequency f, a shutter pulse signal is generated to open and close a pre-specimen shutter in a base TEM apparatus. A pulse is generated per VAC cycle from the targeted phase Φ to Φ +∆Φ with phase width ∆Φ (∆Φ <2π)...
April 29, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28462125/helicobacter-pylori-and-cardiovascular-complications-a-mechanism-based-review-on-role-of-helicobacter-pylori-in-cardiovascular-diseases
#7
REVIEW
Prasad G Jamkhande, Surendra G Gattani, Shaikh Ayesha Farhat
Heart disease comprises a wide class of cardiovascular abnormalities, including ischemic heart disease, myocardial infarction, atherosclerosis, and coronary artery disease. It is the leading cause of death all over the world. Several traditional and novel risk factors, such as infectious and noninfectious agents, have been associated with heart disease. Out of these, Helicobacter pylori has been recently introduced as an important etiological factor for heart disease. Numerous seroepidemiological findings observed H...
December 2016: Integr Med Res
https://www.readbyqxmd.com/read/28460201/deep-sternal-wound-infections-a-severe-complication-after-cardiac-surgery
#8
A Morgante, F Romeo
Sternal Wound Infections (SWI) represent a dangerous complication after cardiac surgery entailing significantly longer hospital stays and worse short-term survival, especially in case of deep infections (DSWI) with the onset of osteomielitis or mediastinitis. The real incidence of SWI can be estimated between 0.25% and 10%; among the risk factors for sternal dehiscences after a longitudinal median sternotomy, several experiences underline the role of diabetes as an independent risk factor for post-operative infections, especially in patients affected by COPD with higher BMI...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28457089/immunogenicity-of-sci-b-vac-a-third-generation-hepatitis-b-vaccine-in-hiv-positive-adults
#9
Danny Alon, Gideon Y Stein, Vered Hadas-Golan, Luba Tau, Tal Brosh, Dan Turner
BACKGROUND: Guidelines recommend hepatitis B virus (HBV) vaccination of all adults positive for human immunodeficiency virus (HIV). Immune responses to single-antigen HBV vaccine among HIV-positive patients are low when compared with HIV-negative adults. Sci-B-Vac™ is a recombinant third-generation HBV that may be advantageous in this population. OBJECTIVES: To examine the immune responses to Sci-B-Vac among HIV-positive adults. METHODS: We conducted a prospective cohort study involving HIV-positive adults who had negative HBV serology (HBSAg, HBSAb, HBcoreAb)...
March 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28456864/a-randomized-controlled-clinical-trial-to-evaluate-the-immunogenicity-of-a-pres-s-hepatitis-b-vaccine-sci-b-vac%C3%A2-as-compared-to-engerix-b-%C3%A2-among-vaccine-na%C3%A3-ve-and-vaccine-non-responder-dialysis-patients
#10
E Elhanan, M Boaz, I Schwartz, D Schwartz, G Chernin, H Soetendorp, A Gal Oz, A Agbaria, T Weinstein
BACKGROUND: Dialysis patients have a suboptimal response to hepatitis B (HBV) vaccination. This study aimed to compare the immunogenicity of two vaccines: the third-generation Sci-B-Vac™ vs. the second-generation Engerix B(®). The cohort included two groups of dialysis patients: naïve and previously vaccinated non-responders. Primary endpoints were antibody titers ≥10 IU/L at 3 and 7 month post-vaccination. Secondary objectives were seroprotection rates in vaccine-naïve patients and in previously vaccinated non-responders...
April 29, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28456342/comparison-of-inflammatory-cytokines-in-peritoneal-fluid-at-source-control-surgery-for-abdominal-sepsis
#11
Michael S Bleszynski, Tiffany Chan, Andrzej K Buczkowski
BACKGROUND: Open abdomen with vacuum assisted closure (VAC) is an alternate method to primary abdominal closure (PAC) in select situations for the management of severe surgical abdominal sepsis or septic shock. Peritoneal cytokines may potentially correlate with deranged physiology and help stratify severity of sepsis. The primary objective of the study was to identify if cytokines can differentiate between patients who underwent PAC or VAC at primary source control laparotomy (SCL). METHODS: Prospective case series including patients with severe abdominal sepsis/septic shock requiring urgent SCL...
April 6, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28433026/variational-koopman-models-slow-collective-variables-and-molecular-kinetics-from-short-off-equilibrium-simulations
#12
Hao Wu, Feliks Nüske, Fabian Paul, Stefan Klus, Péter Koltai, Frank Noé
Markov state models (MSMs) and master equation models are popular approaches to approximate molecular kinetics, equilibria, metastable states, and reaction coordinates in terms of a state space discretization usually obtained by clustering. Recently, a powerful generalization of MSMs has been introduced, the variational approach conformation dynamics/molecular kinetics (VAC) and its special case the time-lagged independent component analysis (TICA), which allow us to approximate slow collective variables and molecular kinetics by linear combinations of smooth basis functions or order parameters...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28431812/potency-of-whole-virus-particle-and-split-virion-vaccines-using-dissolving-microneedle-against-challenges-of-h1n1-and-h5n1-influenza-viruses-in-mice
#13
Akihiro Nakatsukasa, Koji Kuruma, Masatoshi Okamatsu, Takahiro Hiono, Mizuho Suzuki, Keita Matsuno, Hiroshi Kida, Takayoshi Oyamada, Yoshihiro Sakoda
Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies of split virion and whole virus particle (WVP) vaccines prepared from A/Puerto Rico/8/1934 (H1N1) and A/duck/Hokkaido/Vac-3/2007 (H5N1), respectively, were evaluated. MN vaccination induced higher neutralizing antibody responses than SC vaccination in mice. Moreover, MN vaccination with a lower dose of antigens conferred protective immunity against lethal challenges of influenza viruses than SC vaccination in mice...
April 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28427404/retraction-note-evaluation-of-low-cost-custom-made-vac-therapy-compared-with-conventional-wound-dressings-in-the-treatment-of-non-healing-lower-limb-ulcers-in-lower-socio-economic-group-patients-of-kashmir-valley
#14
Zameer Ali, Afshan Anjum, Lubna Khurshid, Hamayun Ahad, Saheel Maajid, Shabir Ahmad Dhar
No abstract text is available yet for this article.
April 20, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28410232/vacquinol-1-inducible-cell-death-in-glioblastoma-multiforme-is-counter-regulated-by-trpm7-activity-induced-by-exogenous-atp
#15
Philip Sander, Haouraa Mostafa, Ayman Soboh, Julian M Schneider, Andrej Pala, Ann-Kathrin Baron, Barbara Moepps, C Rainer Wirtz, Michael Georgieff, E Marion Schneider
Glioblastomas (GBM) are the most malignant brain tumors in humans and have a very poor prognosis. New therapeutic options are urgently needed. A novel drug, Vacquinol-1 (Vac), a quinolone derivative, displays promising properties by inducing rapid cell death in GBM but not in non-transformed tissues. Features of this type of cell death are compatible with a process termed methuosis. Here we tested Vac on a highly malignant glioma cell line observed by long-term video microscopy. Human dental-pulp stem cells (DPSCs) served as controls...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28406138/inhibition-of-endocytic-pathways-impacts-cytomegalovirus-maturation
#16
Madeline A Archer, Teal M Brechtel, Leslie E Davis, Rinkuben C Parmar, Mohammad H Hasan, Ritesh Tandon
Endocytic processes are critical for cellular entry of several viruses; however, the role of endocytosis in cellular trafficking of viruses beyond virus entry is only partially understood. Here, we utilized two laboratory strains (AD169 and Towne) of human cytomegalovirus (HCMV), which are known to use cell membrane fusion rather than endocytosis to enter fibroblasts, in order to study a post-entry role of endocytosis in HCMV life cycle. Upon pharmacological inhibition of dynamin-2 or clathrin terminal domain (TD) ligand association, these strains entered the cells successfully based on the expression of immediate early viral protein...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28396234/intraoral-vacuum-assisted-closure-therapy-a-pilot-study-in-medication-related-osteonecrosis-of-the-jaw
#17
Johannes Laimer, Otto Steinmassl, Martin Hechenberger, Michael Rasse, Rajmond Pikula, Emanuel Bruckmoser
PURPOSE: For approximately 2 decades, vacuum-assisted closure (VAC) therapy has been widely used for the management of complex wounds and soft tissue defects on the external surface of the body. As yet, this technique has not been studied for intraoral wound management. Therefore, this study evaluated the feasibility, safety, and effectiveness of intraoral VAC therapy in patients with medication-related osteonecrosis of the jaw (MRONJ). PATIENTS AND METHODS: After successful construction of an intraoral device providing sufficient airtight sealing, individually manufactured appliances were used in a prospective clinical trial of 3 patients using the VAC therapy system...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28391076/improvised-vacuum-assisted-closure-for-severe-neck-infection-in-poorly-equipped-conditions
#18
S Adam, H D Sama, C Chossegros, M K Bouassalo, M Y Akpoto, E Kpemissi
INTRODUCTION: Dental infections are common and are mainly due to dental caries. When left untreated, these infections can lead to severe life-threatening sepsis. CASE REPORT: The authors reported a case of a severe odontogenic deep neck space infection in a 54-year-old male. The patient was a heavy smoker with incidentally discovered diabetes. He was successfully treated by surgical drainage combined with an improvised Vacuum-Assisted Closure (VAC) system. The results of surgical drainage followed by insertion of an improvised VAC system were spectacular...
April 6, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28353538/long-term-alcohol-use-patterns-and-hiv-disease-severity-a-joint-trajectory-analysis
#19
Brandon David Lewis Marshall, Janet P Tate, Kathleen A Mcginnis, Kendall J Bryant, Robert L Cook, E Jennifer Edelman, Julie R Gaither, Christopher W Kahler, Don Operario, David A Fiellin, Amy C Justice
OBJECTIVE: We examined the relationship between alcohol use trajectories and HIV disease severity among men and women participating in the Veterans Aging Cohort Study (VACS). DESIGN: Prospective cohort of HIV-infected persons in care at eight US Veterans Health Administration sites. METHODS: Between 2002 and 2010, we assessed alcohol consumption annually using the AUDIT-C. HIV disease severity was ascertained using the VACS Index, a validated measure of morbidity and all-cause mortality...
March 28, 2017: AIDS
https://www.readbyqxmd.com/read/28345371/ewma-document-negative-pressure-wound-therapy
#20
Jan Apelqvist, Christian Willy, Ann-Mari Fagerdahl, Marco Fraccalvieri, Malin Malmsjö, Alberto Piaggesi, Astrid Probst, Peter Vowden
1. Introduction Since its introduction in clinical practice in the early 1990's negative pressure wounds therapy (NPWT) has become widely used in the management of complex wounds in both inpatient and outpatient care.(1) NPWT has been described as a effective treatment for wounds of many different aetiologies(2,3) and suggested as a gold standard for treatment of wounds such as open abdominal wounds,(4-6) dehisced sternal wounds following cardiac surgery(7,8) and as a valuable agent in complex non-healing wounds...
March 1, 2017: Journal of Wound Care
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