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https://www.readbyqxmd.com/read/28648043/-advances-in-the-research-of-application-of-vacuum-assisted-closure-in-wound-healing-and-its-mechanism
#1
S L Xie, G H Guo, D H Min
As a new generation of negative pressure drainage technology, vacuum-assisted closure (VAC) can provide stable and persistent negative pressure, and there are several modes to choose from. VAC plays an important role in closing wounds quickly, controlling infection, promoting angiogenesis, increasing blood flow, and promoting granulation tissue growth of wounds. It is now widely applied in all kinds of acute, chronic, and special wounds in clinic with good therapeutic results. However, we need to pay attention to contraindications and complications of VAC when it is used, avoiding secondary damage due to improper treatment...
June 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28630851/vacuum-assisted-closure-in-patients-with-post-operative-infections-after-instrumented-spine-surgery-a-series-of-12-cases
#2
Maya Kale, Pravin Padalkar, Varshil Mehta
INTRODUCTION: Post-operative wound infections after spinal surgery is a very serious problem, leading to a risk of significant morbidity which may even lead to prolonged hospitalization. Various treatment protocols have been recommended for debridement, antibiotic, and soft-tissue management, but with mixed results. However, the risk of morbidity is still high with these treatment options. Vacuum-assisted closure (VAC) system has been gaining popularity recently in the management of subacute, acute, and chronic wounds...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28628999/synthesis-characterisation-and-phase-transition-behaviour-of-temperature-responsive-physically-crosslinked-poly-n-vinylcaprolactam-based-polymers-for-biomedical-applications
#3
Shane C Halligan, Maurice B Dalton, Kieran A Murray, Yixiao Dong, Wenxin Wang, John G Lyons, Luke M Geever
Poly (N-vinylcaprolactam) (PNVCL) is a polymer which offers superior characteristics for various potential medical device applications. In particular it offers unique thermoresponsive capabilities, which fulfils the material technology constraints required in targeted drug delivery applications. PNVCL phase transitions can be tailored in order to suit the requirements of current and next generation devices, by modifying the contents with regard to the material composition and aqueous polymer concentration. In this study, physically crosslinked Poly (N-vinylcaprolactam)-Vinyl acetate (PNVCL-VAc) copolymers were prepared by photopolymerisation...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628099/toxoplasma-depends-on-lysosomal-consumption-of-autophagosomes-for-persistent-infection
#4
Manlio Di Cristina, Zhicheng Dou, Matteo Lunghi, Geetha Kannan, My-Hang Huynh, Olivia L McGovern, Tracey L Schultz, Aric J Schultz, Alyssa J Miller, Beth M Hayes, Wouter van der Linden, Carla Emiliani, Matthew Bogyo, Sébastien Besteiro, Isabelle Coppens, Vern B Carruthers
Globally, nearly 2 billion people are infected with the intracellular protozoan Toxoplasma gondii(1). This persistent infection can cause severe disease in immunocompromised people and is epidemiologically linked to major mental illnesses(2) and cognitive impairment(3). There are currently no options for curing this infection. The lack of effective therapeutics is due partly to a poor understanding of the essential pathways that maintain long-term infection. Although it is known that Toxoplasma replicates slowly within intracellular cysts demarcated with a cyst wall, precisely how it sustains itself and remodels organelles in this niche is unknown...
June 19, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28594480/comparison-of-drug-benefits-provided-by-veterans-affairs-canada-and-the-canadian-forces-health-services-group
#5
Matthew Chow, Charles J Wicks, Janice Ma, Sylvain Grenier
BACKGROUND: Drug benefits are provided at public expense to all actively serving Canadian Armed Forces (CAF) personnel, with ongoing drug coverage offered by Veterans Affairs Canada (VAC) for selected conditions following termination of employment. Differences in drug coverage between these programs could introduce risks for treatment disruption. OBJECTIVES: Work was undertaken to establish a process that would allow systematic comparison of the entire VAC and CAF formularies, and to identify and explain discordant listings in 14 therapeutic categories that pose risk of adverse outcomes with sudden treatment interruption...
May 23, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28566587/the-superiority-of-vonoprazan-based-first-line-triple-therapy-with-clarithromycin-a-prospective-multi-center-cohort-study-on-helicobacter-pylori-eradication
#6
Soichiro Sue, Hirofumi Kuwashima, Yuri Iwata, Hiroyuki Oka, Isao Arima, Takehide Fukuchi, Katsuyuki Sanga, Yasuhiro Inokuchi, Yuniba Ishii, Masatomo Kanno, Masahiro Terada, Hitoshi Amano, Makoto Naito, Shigeru Iwase, Hiroshi Okazaki, Kazuto Komatsu, Atsushi Kokawa, Ichiro Kawana, Manabu Morimoto, Toshifumi Saito, Yosuke Kunishi, Akihiko Ikeda, Daisuke Takahashi, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Wataru Shibata, Shin Maeda
Objective We evaluated the safety and efficacy of vonoprazan-based amoxicillin and clarithromycin 7-day triple therapy (VAC) in comparison to proton pump inhibitor (PPI)-based (PAC) as a first-line treatment and vonoprazan-based amoxicillin and metronidazole 7-day triple therapy (VAM) in comparison to PPI-based (PAM) as a second-line treatment for the eradication of Helicobacter pylori in Japan. Methods We performed a non-randomized, multi-center, parallel-group study to compare first-line VAC to PAC and second-line VAM to PAM...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28564367/organometallic-mediated-alternating-radical-copolymerization-of-tert-butyl-2-trifluoromethacrylate-with-vinyl-acetate-and-synthesis-of-block-copolymers-thereof
#7
Sanjib Banerjee, Vincent Ladmiral, Antoine Debuigne, Christophe Detrembleur, S M Wahidur Rahaman, Rinaldo Poli, Bruno Ameduri
Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly(VAc-alt-MAF-TBE) copolymers composed of two electronically distinct monomers: vinyl acetate (VAc, donor, D) and tert-butyl-2-trifluoromethacrylate (MAF-TBE, acceptor, A), with low dispersity (≤1.24) and molar masses up to 57 000 g mol(-1) . These copolymers have a precise 1:1 alternating structure over a wide range of comonomer feed compositions...
May 31, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28548706/45-gy-is-not-sufficient-radiotherapy-dose-for-group-iii-orbital-embryonal-rhabdomyosarcoma-after-less-than-complete-response-to-12-weeks-of-arst0331-chemotherapy-a-report-from-the-soft-tissue-sarcoma-committee-of-the-children-s-oncology-group
#8
Ralph P Ermoian, John Breneman, David O Walterhouse, Yueh-Yun Chi, Jane Meza, James Anderson, Douglas S Hawkins, Andrea A Hayes-Jordan, David M Parham, Torunn I Yock, Sarah S Donaldson, Suzanne L Wolden
BACKGROUND: Recent Children's Oncology Group (COG) trials tested the efficacy of reduced therapy in an effort to lessen late effects compared to the Intergroup Rhabdomyosarcoma Study (IRS) IV regimen with associated hematologic and hepatic toxicity, and infertility. Here, we analyze the efficacy of 45 Gray (Gy) local radiotherapy (RT) in patients with Group III orbital embryonal rhabdomyosarcoma (ERMS) enrolled on the COG low-risk study ARST0331. PROCEDURE: Sixty-two patients with Group III orbital ERMS were treated on ARST0331 with four cycles of vincristine (VCR), dactinomycin (DACT), and cyclophosphamide (CPM; VAC, total cumulative CPM dose 4...
May 26, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28543215/fib-4-stage-of-liver-fibrosis-predicts-incident-heart-failure-among-hiv-infected-and-uninfected-patients
#9
Kaku A So-Armah, Joseph K Lim, Vincent Lo Re, Janet P Tate, H Chang Chung-Chou, Adeel A Butt, Cynthia L Gibert, David Rimland, Vincent C Marconi, Matthew B Goetz, Maria C Rodriguez-Barradas, Michael E DeBakey, Matthew J Budoff, Hilary A Tindle, Jeffrey H Samet, Amy C Justice, Matthew S Freiberg
Liver fibrosis is common, particularly in human immunodeficiency virus infected (HIV+) people. HIV+ people have excess congestive heart failure (CHF) risk compared to uninfected people. It remains unknown if stage of liver fibrosis influences the CHF risk or if HIV or hepatitis C virus (HCV) infection modifies this association. Our objectives were to assess whether: 1) stage of liver fibrosis is independently associated with incident CHF; 2) the association between stage of liver fibrosis and incident CHF is modified by HIV/HCV status...
May 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28541897/capacitive-micro-machined-ultrasound-transducers-for-interstitial-high-intensity-ultrasound-therapies
#10
W Apoutou N'Djin, Bjoern Gerold, Jeremy Vion, Michael Canney, An Nguyen-Dinh, Alexandre Carpentier, Jean-Yves Chapelon
Capacitive Micro-machined Ultrasound Transducers (CMUTs) exhibit several potential advantages over conventional piezo technologies for use in therapeutic ultrasound devices, including: ease of miniaturization and integration with electronics, broad bandwidth (>several MHz), and compatibility with magnetic resonance imaging (MRI). In this work, the electro-acoustic performance of CMUTs designed for interstitial high intensity contact ultrasound (HICU) applications was evaluated and the feasibility of generating ultrasound-induced heating and thermal destruction of biological tissues was studied...
May 24, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28515766/pancreatic-protective-and-hypoglycemic-effects-of-vitex-agnus-castus-l-fruit-hydroalcoholic-extract-in-d-galactose-induced-aging-mouse-model
#11
Akram Ahangarpour, Ali Akbar Oroojan, Layasadat Khorsandi, Seyedeh Asma Najimi
D-galactose induces pancreatic disorder along with aging mouse model. Vitex agnus-castus (VAC) has potential pancreatic protective effect. Hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of VAC hydroalcoholic extract in D-galactose-induced aging female mice. In the present experimental study, 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) were divided into 6 groups of control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28503767/the-world-of-epithelial-sheets
#12
REVIEW
Hisao Honda
An epithelium is a layer of closely connected cells covering the body or lining a body cavity. In this review, several fundamental questions are addressed regarding the epithelium. (i) While an epithelium functions as barrier against the external environment, how is barrier function maintained during its construction? (ii) What determines the apical and basal sides of epithelial layer? (iii) Is there any relationship between the apical side of the epithelium and the apical membrane of an epithelial cell? (iv) Why are hepatocytes (liver cells) called epithelial, even though they differ completely from column-like shape of typical epithelial cells? Keeping these questions in mind, multiple shapes of epithelia were considered, extracting a few of their elemental processes, and constructing a virtual world of epithelia by combining them...
May 14, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28501019/towards-a-feminist-understanding-of-intersecting-violence-against-women-and-children-in-the-family
#13
Sophie Namy, Catherine Carlson, Kathleen O'Hara, Janet Nakuti, Paul Bukuluki, Julius Lwanyaaga, Sylvia Namakula, Barbrah Nanyunja, Milton L Wainberg, Dipak Naker, Lori Michau
While intimate partner violence (IPV) against women and violence against children (VAC) have emerged as distinct fields of research and programming, a growing number of studies demonstrate the extent to which these forms of violence overlap in the same households. However, existing knowledge of how and why such co-occurrence takes place is limited, particularly in the Global South. The current study aims to advance empirical and conceptual understanding of intersecting IPV and VAC within families in order to inform potential programming...
April 27, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28492393/long-term-alcohol-use-patterns-and-hiv-disease-severity
#14
Brandon D L Marshall, Janet P Tate, Kathleen A McGinnis, Kendall J Bryant, Robert L Cook, E Jennifer Edelman, Julie R Gaither, Christopher W Kahler, Don Operario, David A Fiellin, Amy C Justice
OBJECTIVE: We examined the relationship between alcohol use trajectories and HIV disease severity among men and women participating in the Veterans Aging Cohort Study (VACS). DESIGN: Prospective cohort of HIV-infected persons in care at eight US Veterans Health Administration sites. METHODS: Between 2002 and 2010, we assessed alcohol consumption annually using the alcohol use disorders identification test-consumption (AUDIT-C). HIV disease severity was ascertained using the VACS index, a validated measure of morbidity and all-cause mortality...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28488072/modified-components-separation-technique-experience-treating-large-complex-ventral-hernias-at-a-university-hospital
#15
A Torregrosa-Gallud, J Sancho Muriel, J Bueno-Lledó, P García Pastor, J Iserte-Hernandez, S Bonafé-Diana, O Carreño-Sáenz, F Carbonell-Tatay
BACKGROUND: An increasing number of patients have large or complex abdominal wall defects. Component separation technique (CST) is a very effective method for reconstructing complex midline abdominal wall defects in a manner that restores innervated muscle function without excessive tension. Our goal is to show our results by a modified CST for treating large ventral hernias. MATERIALS AND METHODS: A total of 351 patients with complex ventral hernias have been treated over a 10-year period...
May 9, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28482229/detecting-dynamic-responses-of-materials-and-devices-under-an-alternating-electric-potential-by-phase-locked-transmission-electron-microscopy
#16
Kentaro Soma, Stan Konings, Ryotaro Aso, Naoto Kamiuchi, Genki Kobayashi, Hideto Yoshida, Seiji Takeda
An apparatus is developed for transmission electron microscopy (TEM) to acquire image and spectral data, such as TEM images, electron holograms, and electron energy loss spectra, synchronized with the measurement of the dynamic response of a specimen under an applied alternating current (AC) electric potential (voltage, denoted VAC). From a VAC of frequency f, a shutter pulse signal is generated to open and close a pre-specimen shutter in a base TEM apparatus. A pulse is generated per VAC cycle from the targeted phase Φ to Φ +∆Φ with phase width ∆Φ (∆Φ <2π)...
April 29, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28462125/helicobacter-pylori-and-cardiovascular-complications-a-mechanism-based-review-on-role-of-helicobacter-pylori-in-cardiovascular-diseases
#17
REVIEW
Prasad G Jamkhande, Surendra G Gattani, Shaikh Ayesha Farhat
Heart disease comprises a wide class of cardiovascular abnormalities, including ischemic heart disease, myocardial infarction, atherosclerosis, and coronary artery disease. It is the leading cause of death all over the world. Several traditional and novel risk factors, such as infectious and noninfectious agents, have been associated with heart disease. Out of these, Helicobacter pylori has been recently introduced as an important etiological factor for heart disease. Numerous seroepidemiological findings observed H...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28460201/deep-sternal-wound-infections-a-severe-complication-after-cardiac-surgery
#18
A Morgante, F Romeo
Sternal Wound Infections (SWI) represent a dangerous complication after cardiac surgery entailing significantly longer hospital stays and worse short-term survival, especially in case of deep infections (DSWI) with the onset of osteomielitis or mediastinitis. The real incidence of SWI can be estimated between 0.25% and 10%; among the risk factors for sternal dehiscences after a longitudinal median sternotomy, several experiences underline the role of diabetes as an independent risk factor for post-operative infections, especially in patients affected by COPD with higher BMI...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28457089/immunogenicity-of-sci-b-vac-a-third-generation-hepatitis-b-vaccine-in-hiv-positive-adults
#19
Danny Alon, Gideon Y Stein, Vered Hadas-Golan, Luba Tau, Tal Brosh, Dan Turner
BACKGROUND: Guidelines recommend hepatitis B virus (HBV) vaccination of all adults positive for human immunodeficiency virus (HIV). Immune responses to single-antigen HBV vaccine among HIV-positive patients are low when compared with HIV-negative adults. Sci-B-Vac™ is a recombinant third-generation HBV that may be advantageous in this population. OBJECTIVES: To examine the immune responses to Sci-B-Vac among HIV-positive adults. METHODS: We conducted a prospective cohort study involving HIV-positive adults who had negative HBV serology (HBSAg, HBSAb, HBcoreAb)...
March 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28456864/a-randomized-controlled-clinical-trial-to-evaluate-the-immunogenicity-of-a-pres-s-hepatitis-b-vaccine-sci-b-vac%C3%A2-as-compared-to-engerix-b-%C3%A2-among-vaccine-na%C3%A3-ve-and-vaccine-non-responder-dialysis-patients
#20
E Elhanan, M Boaz, I Schwartz, D Schwartz, G Chernin, H Soetendorp, A Gal Oz, A Agbaria, T Weinstein
BACKGROUND: Dialysis patients have a suboptimal response to hepatitis B (HBV) vaccination. This study aimed to compare the immunogenicity of two vaccines: the third-generation Sci-B-Vac™ vs. the second-generation Engerix B(®). The cohort included two groups of dialysis patients: naïve and previously vaccinated non-responders. Primary endpoints were antibody titers ≥10 IU/L at 3 and 7 month post-vaccination. Secondary objectives were seroprotection rates in vaccine-naïve patients and in previously vaccinated non-responders...
April 29, 2017: Clinical and Experimental Nephrology
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