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Streptococcal pharyngitis

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https://www.readbyqxmd.com/read/29144049/characterization-of-children-with-recurrent-eczema-herpeticum-and-response-to-treatment-with-interferon-gamma
#1
Kavita Darji, Stephanie Frisch, Eric Adjei Boakye, Elaine Siegfried
BACKGROUND/OBJECTIVES: Interferon gamma (IFN-γ) has been used treat severe atopic dermatitis, with equivocal results. Recurrent eczema herpeticum is an underappreciated, therapeutically challenging complication of severe atopic dermatitis. Defects in IFN-γ and other cytokine pathways have been identified in individuals with confirmed eczema herpeticum. This suggests possible benefit from IFN-γ treatment for confirmed eczema herpeticum. The objective of the current study was to evaluate immunologic and microbial parameters and response to IFN-γ treatment in children with confirmed eczema herpeticum...
November 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29135828/improved-diagnostic-performance-of-an-immunofluorescence-based-rapid-antigen-detection-test-for-group-a-streptococci-in-children-with-pharyngitis
#2
Laurence Lacroix, Abdessalam Cherkaoui, Diane Schaller, Sergio Manzano, Annick Galetto-Lacour, Ulrich Pfeifer, René Tabin, Alain Gervaix
BACKGROUND: Accurate diagnosis and appropriate treatment of Group A streptococcal (GAS) pharyngitis are important to prevent complications. Most available rapid antigen detection tests (RADTs) have shown excellent specificity but often lack sensitivity. Our objective was to compare the diagnostic performances of a new fluorescence-based immunoassay and a classic immunochromatographic RADT using standard throat culture or PCR as references. MATERIALS/METHODS: Prospective observational study in 2 pediatric emergency departments in children aged 3 to 15 years old presenting with pharyngitis and a McIsaac score ≥ 2...
November 11, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29072309/hla-cw6-and-psoriasis
#3
REVIEW
L Chen, T F Tsai
Psoriasis is a multifactorial disease with a strong genetic background. HLA-Cw6 is one of the most strongly associated psoriasis susceptibility allele. It is repeatedly observed to affect disease course, phenotypic features, severity, comorbidities, and treatment outcomes. To the best of our knowledge, the roles of HLA-Cw6 in psoriasis have not yet been thoroughly reviewed. The worldwide frequency of HLA-Cw6 allele varies greatly, with HLA-Cw6 allele frequency being generally higher in Caucasians compared to Asians...
October 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29045629/signs-and-symptoms-of-group-a-versus-non-group-a-strep-throat-a-meta-analysis
#4
Thuy N Thai, Ariella P Dale, Mark H Ebell
Introduction: Both non-Group A streptococcal (non-GAS) pharyngitis and Group A streptococcal (GAS) pharyngitis are commonly found in patients with sore throat. It is not known whether or not they present with similar signs and symptoms compared to patients with non-streptococcal pharyngitis. Methods: MEDLINE was searched for prospective studies that reported throat culture for both GAS and non-GAS as a reference standard, and reported at least one sign, symptom, or the Centor score...
October 13, 2017: Family Practice
https://www.readbyqxmd.com/read/28989283/abdominal-pain-and-nausea-in-the-diagnosis-of-streptococcal-pharyngitis-in-boys
#5
Hiroshi Igarashi, Naoki Nago, Hiromichi Kiyokawa, Motoharu Fukushi
OBJECTIVES: This study was designed to assess the accuracy of gastrointestinal symptoms, including abdominal pain, nausea, and vomiting, in the diagnosis of Group A streptococcal (GAS) pharyngitis in children and to determine differences in diagnostic accuracy in boys versus girls. METHODS: This retrospective cross-sectional study included 5,755 consecutive patients aged <15 years with fever in the electronic database at a primary care practice. Gastrointestinal symptoms were recorded in the database according to the International Classification of Primary Care codes, and the data were extracted electronically...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28971103/towards-developing-a-vaccine-for-rheumatic-heart-disease
#6
REVIEW
Geethanjali Devadoss Gandhi, Navaneethakrishnan Krishnamoorthy, Ussama M Abdel Motal, Magdi Yacoub
Rheumatic heart disease (RHD) is the most serious manifestations of rheumatic fever, which is caused by group A Streptococcus (GAS or Streptococcus pyogenes) infection. RHD is an auto immune sequelae of GAS pharyngitis, rather than the direct bacterial infection of the heart, which leads to chronic heart valve damage. Although antibiotics like penicillin are effective against GAS infection, improper medical care such as poor patient compliance, overcrowding, poverty, and repeated exposure to GAS, leads to acute rheumatic fever and RHD...
March 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28951419/group-a-streptococcal-pharyngitis-immune-responses-involved-in-bacterial-clearance-and-gas-associated-immunopathologies
#7
REVIEW
Amelia T Soderholm, Timothy C Barnett, Matthew J Sweet, Mark J Walker
Streptococcus pyogenes, the Group A Streptococcus (GAS), is the most common cause of bacterial pharyngitis in children and adults. Innate and adaptive host immune responses are fundamental for defense against streptococcal pharyngitis and are central to the clinical manifestation of disease. Host immune responses also contribute to the severe poststreptococcal immune diseases that constitute the major disease burden for this organism. However, until recently, little was known about the host responses elicited during infection...
September 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28951316/streptococcus-pyogenes-camp-factor-promotes-bacterial-adhesion-and-invasion-in-pharyngeal-epithelial-cells-without-serum-via-pi3k-akt-signaling-pathway
#8
Mie Kurosawa, Masataka Oda, Hisanori Domon, Toshihito Isono, Yuki Nakamura, Issei Saitoh, Haruaki Hayasaki, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao
Streptococcus pyogenes is a bacterium that causes systemic diseases, such as pharyngitis and toxic shock syndrome, via oral- or nasal-cavity infection. S. pyogenes produces various molecules known to function with serum components that lead to bacterial adhesion and invasion in human tissues. In this study, we identified a novel S. pyogenes adhesin/invasin. Our results revealed that CAMP factor promoted streptococcal adhesion and invasion in pharyngeal epithelial Detroit562 cells without serum. Recombinant CAMP factor initially localized on the membranes of cells and then became internalized in the cytosol following S...
September 23, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28930240/anti-bacterial-activity-of-phenolic-compounds-against-streptococcus-pyogenes
#9
Sabrina Macé, Lisbeth Truelstrup Hansen, H P Vasantha Rupasinghe
BACKGROUND: Worldwide, Streptococcus pyogenes is the leading cause of bacterial pharyngitis. To reduce the use of antibiotics, antimicrobial phytochemical-containing remedies, which have long been in use in traditional medicine, may provide new approaches for management of streptococcal pharyngitis. The objective of this study was to assess the inhibitory activities of 25 natural phenolic compounds against three strains of S. pyogenes. METHODS: After an initial screening, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the nine most effective phenolic compounds were determined...
May 1, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28906539/a-programme-to-increase-appropriate-usage-of-benzathine-penicillin-for-management-of-streptococcal-pharyngitis-and-rheumatic-heart-disease-in-zambia
#10
Aidan Long, Joyce Chipili Lungu, Elizabeth Machila, Sherri Schwaninger, Jonathan Spector, Brigitta Tadmor, Mark Fishman, Bongani M Mayosi, John Musuku
Rheumatic heart disease is highly prevalent and associated with substantial morbidity and mortality in many resource-poor areas of the world, including sub-Saharan Africa. Primary and secondary prophylaxis with penicillin has been shown to significantly improve outcomes and is recognised to be the standard of care, with intra-muscular benzathine penicillin G recommended as the preferred agent by many technical experts. However, ensuring compliance with therapy has proven to be challenging. As part of a public-private partnership initiative in Zambia, we conducted an educational and access-to-medicine programme aimed at increasing appropriate use of benzathine penicillin for the prevention and management of rheumatic heart disease, according to national guidelines...
July 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28890879/streptococcal-pharyngitis-in-children-with-painful-throat-missed-opportunities-for-rheumatic-heart-disease-prevention-in-endemic-area-of-africa
#11
EDITORIAL
Geoffrey Madeira, Daniel Chicavel, Alcides Munguambe, José Langa, Ana Mocumbi
No abstract text is available yet for this article.
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28881007/delayed-antibiotic-prescriptions-for-respiratory-infections
#12
REVIEW
Geoffrey Kp Spurling, Chris B Del Mar, Liz Dooley, Ruth Foxlee, Rebecca Farley
BACKGROUND: Concerns exist regarding antibiotic prescribing for respiratory tract infections (RTIs) owing to adverse reactions, cost, and antibacterial resistance. One proposed strategy to reduce antibiotic prescribing is to provide prescriptions, but to advise delay in antibiotic use with the expectation that symptoms will resolve first. This is an update of a Cochrane Review originally published in 2007, and updated in 2010 and 2013. OBJECTIVES: To evaluate the effects on clinical outcomes, antibiotic use, antibiotic resistance, and patient satisfaction of advising a delayed prescription of antibiotics in respiratory tract infections...
September 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28869722/pain-relief-of-sore-throat-with-a-new-anti-inflammatory-throat-lozenge-ibuprofen-25%C3%A2-mg-a-randomised-double-blind-placebo-controlled-international-phase-iii-study
#13
Athmane Bouroubi, Yves Donazzolo, Franck Donath, Ron Eccles, Marc Russo, Nadine Harambillet, Stéphanie Gautier, Agnès Montagne
OBJECTIVE: The aim of this study was to compare the efficacy and safety of a new oromucosal ibuprofen form, ibuprofen 25 mg lozenge, in single and repeat dosing for up to 4 days, to the matched placebo, in the treatment of acute sore throat pain in adults. METHODS: In this randomised, double-blind, placebo-controlled trial, adult patients with non-streptococcal sore throat and signs of moderate-to-severe associated pain (≥5 on the objective Tonsillo-Pharyngitis Assessment 21-point scale and ≥60 mm on the subjective 0-100 mm visual analogue Sore Throat Pain Intensity Scale [STPIS]) were assigned ibuprofen 25 mg (n=194) or matching placebo (n=191) lozenge treatment...
September 4, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28859019/age-specific-antibiotic-prescribing-and-adherence-to-guidelines-in-pediatric-patients-in-primary-care
#14
Verica Ivanovska, Karin Hek, Aukje K Mantel-Teeuwisse, Hubert G M Leufkens, Liset van Dijk
BACKGROUND: Most antibiotics in children are used to treat viral and self-limiting conditions. This study aims to compare physicians' adherence to guidelines on antibiotic prescribing in fever and in ear and respiratory infections to children in different age groups in the Netherlands. METHODS: Data were used from the NIVEL Primary Care Database. For all pediatric episodes of fever, acute otitis media (AOM), streptococcal pharyngitis (strep throat), sinusitis, acute tonsillitis, acute bronchitis/bronchiolitis and pneumonia in 2012, we determined whether national guidelines were followed in regard to whether an antibiotic was prescribed, and the type of antibiotic...
August 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28814443/antibiotic-use-by-pediatric-residents-identifying-opportunities-and-strategies-for-antimicrobial-stewardship
#15
Prateek J Shukla, Maria Behnam-Terneus, Beatriz Cunill-De Sautu, Geovanny F Perez
OBJECTIVES: To determine the antibiotic prescribing practices of pediatric residents and assess how they acquire knowledge leading to prescribing behaviors. METHODS: We performed a cross-sectional electronic survey of all pediatric residents at the Children's National Medical Center and Nicklaus Children's Hospital, assessing antibiotic prescribing patterns for common pediatric infections, use of antibiograms, and factors influencing antibiotic choice. RESULTS: Eighty-five surveys (45%) were returned complete and included in the analysis...
September 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28808160/incremental-contributions-of-fbaa-and-other-impetigo-associated-surface-proteins-to-fitness-and-virulence-of-a-classical-group-a-streptococcal-skin-strain
#16
Candace N Rouchon, Anhphan T Ly, John P Noto, Feng Luo, Sergio Lizano, Debra E Bessen
Group A streptococci (GAS) are highly prevalent human pathogens whose primary ecological niche is the superficial epithelial layers of the throat and/or skin. Many GAS strains with a strong tendency to cause pharyngitis are distinct from strains that tend to cause impetigo; thus, genetic differences between them may confer host tissue-specific virulence. In this study, the FbaA surface protein gene was found to be present in most skin specialist strains but largely absent from a genetically related subset of pharyngitis isolates...
November 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28781106/-diagnosis-and-treatment-of-acute-pharyngitis-is-there-any-benefit-on-ten-day-course-of-antibiotics
#17
Catarina Oliveira Pereira, Daniela Ramos, Patrícia Mação, Gustavo Januário, Luís Januário
INTRODUCTION: In group A streptococcal (GAS) pharyngitis a ten-day course of amoxicillin is recommended. However, short-course treatments seem to be equally effective. The aim of this study was to retrospectively evaluate and compare the outcome of patients treated with 7-day course and 10-day course of amoxicillin. MATERIALS AND METHODS: Retrospective analysis of all GAS pharyngitis admitted to a paediatric emergency department in 2014. Demographic variables, the application and results of the rapid antigenic diagnostic test (RADT), treatment, complications and return in the next 30 days were analysed...
August 3, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28769806/a-red-blood-cell-membrane-camouflaged-nanoparticle-counteracts-streptolysin-o-mediated-virulence-phenotypes-of-invasive-group-a-streptococcus
#18
Tamara Escajadillo, Joshua Olson, Brian T Luk, Liangfang Zhang, Victor Nizet
Group A Streptococcus (GAS), an important human-specific Gram-positive bacterial pathogen, is associated with a broad spectrum of disease, ranging from mild superficial infections such as pharyngitis and impetigo, to serious invasive infections including necrotizing fasciitis and streptococcal toxic shock syndrome. The GAS pore-forming streptolysin O (SLO) is a well characterized virulence factor produced by nearly all GAS clinical isolates. High level expression of SLO is epidemiologically linked to intercontinental dissemination of hypervirulent clonotypes and poor clinical outcomes...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28730858/management-of-children-with-persistent-group-a-streptococcal-carriage
#19
Maria E Zacharioudaki, Emmanouil Galanakis
Chronic GAS carrier state is best defined as the prolonged presence of group A β-haemolytic Streptococcus (GAS) in the pharynx without evidence of infection or inflammation. Chronic GAS carriers have a low risk of immune mediated complications. Persistent pharyngeal carriage often raises management issues. In this study, we review the evidence on the management of persistent GAS carriage in children and propose a management algorithm. Areas covered: Chronic GAS pharyngeal carriage is quite common affecting 10-20% of school-aged children...
July 31, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28683722/epidemiology-of-pharyngitis-as-reported-by-zambian-school-children-and-their-families-implications-for-demand-side-interventions-to-prevent-rheumatic-heart-disease
#20
John Musuku, Joyce C Lungu, Elizabeth Machila, Catherine Jones, Laurence Colin, Sherri Schwaninger, Patrick Musonda, Brigitta Tadmor, Jonathan M Spector, Mark E Engel, Liesl J Zühlke
BACKGROUND: Prompt and appropriate treatment of streptococcal pharyngitis decreases the risk of acute rheumatic fever and rheumatic heart disease (RHD). Understanding public perceptions and behaviors related to sore throat is fundamental to inform health programs aimed at eliminating new cases of RHD in endemic regions. We sought to describe the epidemiology of pediatric pharyngitis and its treatment, as reported by children and their parents or guardians in Lusaka, Zambia. METHODS: This was a cross-sectional investigation using interviews and written surveys, nested in a school-based RHD prevalence study...
July 6, 2017: BMC Infectious Diseases
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