Priscyanne Barreto Siqueira, Mariana Moreno de Sousa Rodrigues, Ísis Salviano Soares de Amorim, Thayssa Gomes da Silva, Matheus da Silva Oliveira, Juliana Alves Rodrigues, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
APE1/REF-1 (apurinic/apyrimidinic endonuclease 1 / redox factor-1) is a protein with two domains, with endonuclease function and redox activity. Its main activity described is acting in DNA repair by base excision repair (BER) pathway, which restores DNA damage caused by oxidation, alkylation, and single-strand breaks. In contrast, the APE1 redox domain is responsible for regulating transcription factors, such as AP-1 (activating protein-1), NF-κB (Nuclear Factor kappa B), HIF-1α (Hypoxia-inducible factor 1-alpha), and STAT3 (Signal Transducers and Activators of Transcription 3)...
January 2, 2024: Molecular Biology Reports