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https://www.readbyqxmd.com/read/28227967/a-stimulation-driven-exoskeleton-for-walking-after-paraplegia
#1
Sarah R Chang, Mark J Nandor, Lu Li, Kevin M Foglyano, John R Schnellenberger, Rudi Kobetic, Roger D Quinn, Ronald J Triolo, Sarah R Chang, Mark J Nandor, Lu Li, Kevin M Foglyano, John R Schnellenberger, Rudi Kobetic, Roger D Quinn, Ronald J Triolo, Mark J Nandor, Rudi Kobetic, Roger D Quinn, John R Schnellenberger, Sarah R Chang, Kevin M Foglyano, Lu Li, Ronald J Triolo
An untethered version of a stimulation-driven exoskeleton was evaluated for its ability to restore walking after paralysis from spinal cord injury. The hybrid neuroprosthesis (HNP) combined a passive variable-constraint exoskeleton for stability and support with functional neuromuscular stimulation (FNS) to contract the paralyzed muscles to drive limb movement. This self-contained HNP was operated by an onboard controller that sampled sensor signals, generated appropriate commands to both the exoskeletal constraints and integrated stimulator, and transmitted data wirelessly via Bluetooth to an off-board computer for real-time monitoring and recording for offline analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227641/optimization-of-an-unpowered-energy-stored-exoskeleton-for-patients-with-spinal-cord-injury
#2
Xinyu Guan, Linhong Ji, Rencheng Wang, Wenjie Huang, Xinyu Guan, Linhong Ji, Rencheng Wang, Wenjie Huang, Rencheng Wang, Xinyu Guan, Wenjie Huang, Linhong Ji
The paper describes a novel unpowered energy-stored exoskeleton (ES-EXO) for spinal cord injured patients in consideration of patients' characteristics and injured levels. It proposed a method to optimize the energy-stored element to decrease the hip joint moment in walking. EMG patterns, ground reaction force and motion data from one participant with complete spinal cord injury at T10 were recorded. A combined human-ES-EXO model was built and the stored-energy element including locations and stiffness of springs were optimized in AnyBody Modeling System...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226949/combined-gait-asymmetry-metric
#3
Tyagi Ramakrishnan, Haris Muratagic, Kyle B Reed, Tyagi Ramakrishnan, Haris Muratagic, Kyle B Reed, Kyle B Reed, Tyagi Ramakrishnan, Haris Muratagic
People with physical impairments often have asymmetric gait. To evaluate if their overall symmetry is improving during intervention, there needs to be a simple metric that can help classify gait patterns that includes multiple measures of gait asymmetry. The Combined Gait Asymmetry Metric presented here is based on the Mahalanobis distance of multiple step parameters. We tested able-bodied subjects with perturbations that involve a change in leg length, the addition of ankle weights, and a combination of both perturbations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225835/mulberry-extract-improves-glucose-tolerance-and-decreases-insulin-concentrations-in-normoglycaemic-adults-results-of-a-randomised-double-blind-placebo-controlled-study
#4
Mark Lown, Richard Fuller, Helen Lightowler, Ann Fraser, Andrew Gallagher, Beth Stuart, Christopher Byrne, George Lewith
BACKGROUND: High sugar and refined carbohydrate intake is associated with weight gain, increased incidence of diabetes and is linked with increased cardiovascular mortality. Reducing the health impact of poor quality carbohydrate intake is a public health priority. Reducose, a proprietary mulberry leaf extract (ME), may reduce blood glucose responses following dietary carbohydrate intake by reducing absorption of glucose from the gut. METHODS: A double-blind, randomised, repeat measure, phase 2 crossover design was used to study the glycaemic and insulinaemic response to one reference product and three test products at the Functional Food Centre, Oxford Brooks University, UK...
2017: PloS One
https://www.readbyqxmd.com/read/28225796/what-can-we-learn-about-beat-perception-by-comparing-brain-signals-and-stimulus-envelopes
#5
Molly J Henry, Björn Herrmann, Jessica A Grahn
Entrainment of neural oscillations on multiple time scales is important for the perception of speech. Musical rhythms, and in particular the perception of a regular beat in musical rhythms, is also likely to rely on entrainment of neural oscillations. One recently proposed approach to studying beat perception in the context of neural entrainment and resonance (the "frequency-tagging" approach) has received an enthusiastic response from the scientific community. A specific version of the approach involves comparing frequency-domain representations of acoustic rhythm stimuli to the frequency-domain representations of neural responses to those rhythms (measured by electroencephalography, EEG)...
2017: PloS One
https://www.readbyqxmd.com/read/28225787/forest-dynamics-in-the-u-s-indicate-disproportionate-attrition-in-western-forests-rural-areas-and-public-lands
#6
Sheng Yang, Giorgos Mountrakis
Forests are experiencing significant changes; studying geographic patterns in forests is critical in understanding the impact of forest dynamics to biodiversity, soil erosion, water chemistry and climate. Few studies have examined forest geographic pattern changes other than fragmentation; however, other spatial processes of forest dynamics are of equal importance. Here, we study forest attrition, the complete removal of forest patches, that can result in complete habitat loss, severe decline of population sizes and species richness, and shifts of local and regional environmental conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28225519/a-cytokine-pattern-that-differentiates-preseroconversion-from-postseroconversion-phases-of-primary-hiv-infection
#7
Lucia Pastor, Erica Parker, Jorge Carrillo, Victor Urrea, Laura Fuente-Soro, Durval Respeito, Chenjerai Jairoce, Inacio Mandomando, Julià Blanco, Denise Naniche
BACKGROUND: During acute HIV infection, HIV actively replicates but seroconversion has not yet occurred. Primary HIV infection (PHI) is characterized by a transient nonspecific febrile illness, a massive inflammatory response, and the progressive appearance of anti-HIV-specific antibodies. In this study, we have identified patterns of inflammatory biomarkers associated with the innate immunological reaction before completion of a full humoral response. METHODS: A symptom-based screening was used to identify acute HIV infection in the Manhiça District Hospital in Mozambique...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28224608/inter-and-intrarater-clinician-agreement-on-joint-motion-patterns-during-gait-in-children-with-cerebral-palsy
#8
Angela Nieuwenhuys, Eirini Papageorgiou, Guy Molenaers, Davide Monari, Tinne de Laet, Kaat Desloovere
AIM: This study aimed to quantify the inter- and intrarater clinician agreement on joint motion patterns in children with spastic cerebral palsy (CP), which were recently specified by a Delphi consensus study. It also examined whether experience with three-dimensional gait analysis (3DGA) is a prerequisite for using the patterns. METHOD: The experimental group consisted of 82 patients with CP (57 males, 25 females; uni-/bilateral CP [n=27/55]; Gross Motor Function Classification System levels I to III; mean age 9y 5mo [range 4y-18y])...
February 22, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28224083/comparative-genomic-analysis-of-eutherian-kallikrein-genes
#9
Marko Premzl
The present study made attempts to update and revise eutherian kallikrein genes implicated in major physiological and pathological processes and in medical molecular diagnostics. Using eutherian comparative genomic analysis protocol and free available genomic sequence assemblies, the tests of reliability of eutherian public genomic sequences annotated most comprehensive curated third party data gene data set of eutherian kallikrein genes including 121 complete coding sequences among 335 potential coding sequences...
March 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28222980/acute-water-quality-criteria-for-polycyclic-aromatic-hydrocarbons-pesticides-plastic-additives-and-4-nonylphenol-in-seawater
#10
I Durán, R Beiras
Probabilistic environmental quality criteria for Naphthalene (Nap), Phenanthrene (Phe), Fluoranthene (Flu), Pyrene (Pyr), Triclosan (TCS), Tributyltin (TBT), Chlorpyrifos (CPY), Diuron (DUR), γ-Hexaclorocyclohexane (γ-HCH), Bisphenol A (BPA) and 4-Nonylphenol (4-NP) were derived from acute toxicity data using saltwater species representative of marine ecosystems, including algae, mollusks, crustaceans, echinoderms and chordates. Preferably, data concerns sublethal endpoints and early life stages from bioassays conducted in our laboratory, but the data set was completed with a broad literature survey...
February 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28222671/reversal-of-hypermethylation-and-reactivation-of-glutathione-s-transferase-pi-1-gene-by-curcumin-in-breast-cancer-cell-line
#11
Umesh Kumar, Ujjawal Sharma, Garima Rathi
One of the mechanisms for epigenetic silencing of tumor suppressor genes is hypermethylation of cytosine residue at CpG islands at their promoter region that contributes to malignant progression of tumor. Therefore, activation of tumor suppressor genes that have been silenced by promoter methylation is considered to be very attractive molecular target for cancer therapy. Epigenetic silencing of glutathione S-transferase pi 1, a tumor suppressor gene, is involved in various types of cancers including breast cancer...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28222561/validation-of-the-standardized-touchscreen-assessment-of-cognition-with-neurotypical-adults
#12
Sarah E Wallace, Elena Donoso Brown, Andrea D Fairman, Koren Beardshall, Anna Olexsovich, Alicia Taylor, James B Schreiber
BACKGROUND: Portable electronic devices are increasingly being used for clinical assessment of individuals with cognitive deficits. Prior to implementation of tablet-based assessments, comparison with other standard measures is needed. OBJECTIVE: The study purpose was to compare an iPad administered cognitive assessment known as the Standardized Touchscreen Assessment of Cognition (STAC) to the Cognitive Linguistic Quick Test (CLQT) and the Cognitive Assessment of Minnesota (CAM)...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222239/evolutionary-rescue-and-local-adaptation-under-different-rates-of-temperature-increase-a-combined-analysis-of-changes-in-phenotype-expression-and-genotype-frequency-in-paramecium-microcosms
#13
Joshua Killeen, Claire Gougat-Barbera, Sascha Krenek, Oliver Kaltz
Evolutionary Rescue (ER) occurs when populations, which have declined due to rapid environmental change, recover through genetic adaptation. The success of this process and the evolutionary trajectory of the population strongly depend on the rate of environmental change. Here we investigated how different rates of temperature increase (from 23°C to 32°C) affect population persistence and evolutionary change in experimental microcosms of the protozoan Paramecium caudatum. Consistent with theory on ER, we found that those populations experiencing the slowest rate of temperature increase were the least likely to become extinct and tended to be the best adapted to the new temperature environment...
February 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28222169/decellularized-wharton-s-jelly-from-human-umbilical-cord-as-a-novel-3d-scaffolding-material-for-tissue-engineering-applications
#14
Sushma Jadalannagari, Gabriel Converse, Christopher McFall, Eric Buse, Michael Filla, Maria T Villar, Antonio Artigues, Adam J Mellot, Jinxi Wang, Michael S Detamore, Richard A Hopkins, Omar S Aljitawi
In tissue engineering, an ideal scaffold attracts and supports cells thus providing them with the necessary mechanical support and architecture as they reconstruct new tissue in vitro and in vivo. This manuscript details a novel matrix derived from decellularized Wharton's jelly (WJ) obtained from human umbilical cord for use as a scaffold for tissue engineering application. This decellularized Wharton's jelly matrix (DWJM) contained 0.66 ± 0.12 μg/mg sulfated glycosaminoglycans (GAGs), and was abundant in hyaluronic acid, and completely devoid of cells...
2017: PloS One
https://www.readbyqxmd.com/read/28221911/molecular-subtyping-and-source-attribution-of-campylobacter-isolated-from-food-animals
#15
Gregory H Tyson, Heather P Tate, Jason Abbott, Thu-Thuy Tran, Claudine Kabera, Emily Crarey, Shenia Young, Patrick F McDERMOTT, Grisselle Sprague, Mark Campbell, Oyewole Adeyemo, Johnette Browne-Silva, Michael Myers, Sutawee Thitaram, Shaohua Zhao
Campylobacter spp. commonly cause gastrointestinal illness in humans. Poultry meats have long been considered the predominant source of these infections, but few in-depth Campylobacter source attribution studies have been completed. We analyzed more than 1,300 Campylobacter isolates recovered from a number of animal and food sources, including dairy and beef cattle, pigs, poultry, and retail poultry meat, and compared them with Campylobacter isolates recovered from human clinical samples. Each isolate was subtyped using pulsed-field gel electrophoresis (PFGE) with SmaI and queried against the Centers for Disease Control and Prevention PulseNet database to identify human isolates with indistinguishable patterns...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221880/spread-of-a-major-clone-of-salmonella-enterica-serotype-enteritidis-in-poultry-and-in-salmonellosis-outbreaks-in-southern-brazil
#16
Karen Apellanis Borges, Thales Quedi Furian, Sara Neves de Souza, Eduardo César Tondo, André Felipe Streck, Carlos Tadeu Pippi Salle, Hamilton Luiz de Souza Moraes, Vladimir Pinheiro do Nascimento
Salmonella spp. are among the most important agents of foodborne diseases all over the world. Human Salmonella outbreaks are often associated with the consumption of poultry products (meat and eggs), and one of the most prevalent serotypes associated with these products is Salmonella Enteritidis. Brazil is one of the most important poultry exporters in the world. In southern Brazil, three closely related clones of Salmonella Enteritidis have been responsible for the majority of foodborne Salmonella outbreaks over the past decade...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28220940/pharmacologic-conversion-during-dofetilide-treatment-for-persistent-atrial-fibrillation
#17
Jonathan S Steinberg, Yash Shah, Barbara Szepietowska
BACKGROUND: Dofetilide is a pure IKr blocker and is one of the few drugs specifically studied and approved in the United States for the management of persistent AF. Dofetilide has been noted to have a high rate of pharmacologic conversion during initial dosing in prior smaller studies. The intent of the study was to examine the safety of an inpatient loading strategy, and the incidence and patterns of pharmacologic conversion by dofetilide during the treatment of persistent AF in a large consecutive cohort...
February 21, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28220759/musculoskeletal-model-based-control-interface-mimics-physiologic-hand-dynamics-during-path-tracing-task
#18
Dustin Lee Crouch, Helen Huang
OBJECTIVE: We investigated the feasibility of a novel, customizable, simplified EMG-driven musculoskeletal model for estimating coordinated hand and wrist motions during a real-time path tracing task. APPROACH: A two-degree-of-freedom (DOF) computational musculoskeletal model was implemented for real-time EMG-driven control of a stick figure hand displayed on a computer screen. After 5 to 10 minutes of undirected practice, subjects were given 3 attempts to trace 10 straight paths, one at a time, with the fingertip of the virtual hand...
February 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28220574/selective-use-of-the-electrocardiogram-in-pediatric-preparticipation-athletic-examinations-among-pediatric-primary-care-providers
#19
Bradley C Clark, Joshua M Hayman, Charles I Berul, Kristin M Burns, Jonathan R Kaltman
OBJECTIVES: Recent literature examining insurance administrative data suggests that a selective approach, with concurrent history and physical exam (H&P), for obtaining an electrocardiogram (ECG) as a part of a preparticipation examination (PPE) for pediatric athletes is commonly used in the primary care setting demonstrating a high rate of disease detection. We sought to understand practice patterns of providers with regard to usage of ECG as a part of PPE. METHODS: Utilizing an online survey, we queried primary care providers regarding their practice patterns, rationale, and concerns regarding use of ECGs as a part of the PPE...
February 21, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28220474/buprenorphine-for-managing-opioid-withdrawal
#20
REVIEW
Linda Gowing, Robert Ali, Jason M White, Dalitso Mbewe
BACKGROUND: Managed withdrawal is a necessary step prior to drug-free treatment or as the endpoint of substitution treatment. OBJECTIVES: To assess the effects of buprenorphine versus tapered doses of methadone, alpha2-adrenergic agonists, symptomatic medications or placebo, or different buprenorphine regimens for managing opioid withdrawal, in terms of the intensity of the withdrawal syndrome experienced, duration and completion of treatment, and adverse effects...
February 21, 2017: Cochrane Database of Systematic Reviews
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