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https://www.readbyqxmd.com/read/28340045/age-related-patterns-in-cancer-pain-and-its-psychosocial-impact-investigating-the-role-of-variability-in-physical-and-mental-health-quality-of-life
#1
Lynn R Gauthier, Robert H Dworkin, David Warr, Rebecca Pillai Riddell, Alison K Macpherson, Gary Rodin, Camilla Zimmermann, S Lawrence Librach, Malcolm Moore, Frances A Shepherd, Lucia Gagliese
Objective. : Age-related patterns in cancer pain remain equivocal. Most studies ignore heterogeneity across multiple domains of well-being, and the potential role of physical (PH) and mental health (MH) quality of life (QOL) in these age-related patterns is unknown. We investigated the relationships between age and cancer pain intensity, qualities, and interference, and physical and psychosocial adaptation and the interaction between age and PH and MH QOL on pain and adaptation to cancer pain...
March 3, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340044/oral-ghrelin-receptor-agonist-mk-0677-increases-serum-insulin-like-growth-factor-1-in-hemodialysis-patients-a-randomized-blinded-study
#2
Garland A Campbell, James T Patrie, Bruce D Gaylinn, Michael O Thorner, Warren K Bolton
Background: . Protein-energy wasting (PEW) in end-stage renal disease (ESRD) patients is associated with increased morbidity and mortality, but options for treatment are limited. Growth hormone (GH) increases insulin-like growth factor 1 (IGF-1), with improved nutritional parameters, but must be given subcutaneously and does not provide normal GH secretion patterns. MK-0677, an oral ghrelin receptor agonist (GRA), maintains normal GH secretion and increases lean body mass in normal subjects; it has not been studied in dialysis patients, an essential step in assessing efficacy and safety prior to clinical trials...
March 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339570/frequency-of-different-electrocardiographic-abnormalities-in-a-large-cohort-of-spanish-workers
#3
Jorge Rodríguez-Capitán, Ana Fernández-Meseguer, José Manuel García-Pinilla, Eva Calvo-Bonacho, Manuel Jiménez-Navarro, Teresa García-Margallo, Fernando Cabrera-Bueno, Ignacio Echeverria-Lucotti, Juan José Gómez-Doblas, Eduardo De Teresa-Galván
Aims: Our aim was to describe the electrocardiographic findings of a large sample of Spanish workers from several different employment sectors. Methods and results: Between May 2008 and November 2010, 13 495 consecutive 12-lead resting electrocardiograms (ECGs) were obtained during health examinations of working adults aged 16-74 years in 5 cities in different regions of Spain. Of those, 13 179 ECGs suitable for interpretation were included in this study. All tracings were classified by the same cardiologist, according to the Minnesota Code criteria...
October 6, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28338951/measuring-transitions-in-sexual-risk-among-men-who-have-sex-with-men-the-novel-use-of-latent-class-and-latent-transition-analysis-in-hiv-sentinel-surveillance
#4
Anna L Wilkinson, Carol El-Hayek, Christopher K Fairley, Norm Roth, B K Tee, Emma McBryde, Margaret Hellard, Mark Stoové
New combination human acquired deficiency (HIV) prevention strategies that include biomedical and primary prevention approaches add complexity to the task of measuring sexual risk. Latent transition models are beneficial for understanding complex phenomena; therefore, we trialed the application of latent class and latent transition models to HIV surveillance data. Our aims were to identify sexual risk states and model individuals' transitions between states. A total of 4,685 HIV-negative men who have sex with men (MSM) completed behavioral questionnaires alongside tests for HIV and sexually transmissible infections at one of 2 Melbourne, Victoria, Australia, general practices (2007-2013)...
March 10, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28338745/circadian-oscillations-of-microbial-and-functional-composition-in-the-human-salivary-microbiome
#5
Lena Takayasu, Wataru Suda, Kageyasu Takanashi, Erica Iioka, Rina Kurokawa, Chie Shindo, Yasue Hattori, Naoko Yamashita, Suguru Nishijima, Kenshiro Oshima, Masahira Hattori
The human microbiomes across the body evidently interact with various signals in response to biogeographical physiological conditions. To understand such interactions in detail, we investigated how the salivary microbiome in the oral cavity would be regulated by host-related signals. Here, we show that the microbial abundance and gene participating in keeping the human salivary microbiome exhibit global circadian rhythm. Analysis of the 16S rRNA sequences of salivary microbial samples of six healthy adults collected at 4-h intervals for three days revealed that the microbial genera accounting for 68...
February 23, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28338493/surgery-for-recurrent-uterine-cancer-surgical-outcomes-and-implications-for-survival-a-case-series
#6
Lavinia Domenici, Katherine Nixon, Flavia Sorbi, Maria Kyrgiou, Joseph Yazbek, Marcia Hall, Jeremy Campbell, Norma Gibbons, Won-Ho Edward Park, Hani Gabra, Christina Fotopoulou
OBJECTIVE: The purpose of this study was to describe the patterns of relapse in uterine cancer (UC) and the role of surgery in the recurrent setting. METHODS: We describe surgical and clinical outcomes of all patients who underwent surgery for recurrent UC in a gynecological oncology tertiary referral center between May 1, 2013, and April 30, 2016. Progression-free survival and overall survival were estimated using Kaplan-Meier methods with the surgery at relapse being the starting point...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28337820/selective-radiofrequency-stimulation-of-the-dorsal-root-ganglion-drg-as-a-method-for-predicting-targets-for-neuromodulation-in-patients-with-post-amputation-pain-a-case-series
#7
Corey W Hunter, Ajax Yang, Tim Davis
OBJECTIVE: While spinal cord stimulation (SCS) has established itself as an accepted and validated treatment for neuropathic pain, there are a number of conditions where it has experienced less, long-term success: post amputee pain (PAP) being one of them. Dorsal root ganglion (DRG) stimulation has shown great promise, particularly in conditions where traditional SCS has fallen short. One major difference between DRG stimulation and traditional SCS is the ability to provide focal stimulation over targeted areas...
March 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28337801/cross-cultural-comparisons-of-drinking-motives-in-10-countries-data-from-the-drinc-project
#8
Sean P Mackinnon, Marie-Eve Couture, M L Cooper, Emmanuel Kuntsche, Roisin M O'Connor, Sherry H Stewart
INTRODUCTION AND AIMS: This study tested the measurement invariance of the Drinking Motives Questionnaire-Revised Short Form (DMQ-R-SF) in undergraduates across 10 countries. We expected the four-factor structure to hold across countries, and for social motives to emerge as the most commonly endorsed motive, followed by enhancement, coping and conformity motives. We also compared individualistic and collectivistic countries to examine potential differences in the endorsement of drinking motives when countries were divided according to this broad cultural value...
March 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28337096/morphological-pattern-of-endometrial-biopsies-in-southwestern-nigeria
#9
Y M Abdullahi, M A Ajani, O Iyapo, K O Aramide, C A Okolo, Eeu Akang
BACKGROUND: Endometrium remains the most sensitive indicator of ovarian function and endometrial biopsy is one of the diagnostic procedures in endometrial pathology. The current study was carried out to examine the morphological pattern of endometrial biopsies in Ibadan, South-western Nigeria and compare the results with similar studies. METHOD: A retrospective study was undertaken to review all cases of endometrial biopsies received in the Department of Pathology, University College Hospital, Ibadan between January 1999 and December 2008...
December 2016: Annals of Ibadan Postgraduate Medicine
https://www.readbyqxmd.com/read/28336851/nano-photonic-structures-for-light-trapping-in-ultra-thin-crystalline-silicon-solar-cells
#10
Prathap Pathi, Akshit Peer, Rana Biswas
Thick wafer-silicon is the dominant solar cell technology. It is of great interest to develop ultra-thin solar cells that can reduce materials usage, but still achieve acceptable performance and high solar absorption. Accordingly, we developed a highly absorbing ultra-thin crystalline Si based solar cell architecture using periodically patterned front and rear dielectric nanocone arrays which provide enhanced light trapping. The rear nanocones are embedded in a silver back reflector. In contrast to previous approaches, we utilize dielectric photonic crystals with a completely flat silicon absorber layer, providing expected high electronic quality and low carrier recombination...
January 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28336464/new-insights-into-the-codon-usage-patterns-of-the-bactericidal-permeability-increasing-bpi-gene-across-nine-species
#11
Wei-Yun Qin, Li-Na Gan, Ri-Wei Xia, Shou-Yong Sun, Guo-Qiang Zhu, Sheng-Long Wu, Wen-Bin Bao
Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. Non-uniform usage of synonymous codons for a specific amino acid during translation of a protein is known as codon usage bias (CUB). Analysis of CUB and compositional dynamics of coding sequences could contribute to a better understanding of the molecular mechanism and the evolution of a particular gene. In this study, we performed CUB analysis of the complete coding sequences of the BPI gene from nine different species...
March 20, 2017: Gene
https://www.readbyqxmd.com/read/28336213/transient-and-permanent-changes-in-dna-methylation-patterns-in-inorganic-arsenic-mediated-epithelial-to-mesenchymal-transition
#12
Meredith Eckstein, Matthew Rea, Yvonne N Fondufe-Mittendorf
Chronic low dose inorganic arsenic exposure causes cells to take on an epithelial-to-mesenchymal phenotype, which is a crucial process in carcinogenesis. Inorganic arsenic is not a mutagen and thus epigenetic alterations have been implicated in this process. Indeed, during the epithelial-to-mesenchymal transition, morphologic changes to cells correlate with changes in chromatin structure and gene expression, ultimately driving this process. However, studies on the effects of inorganic arsenic exposure/withdrawal on the epithelial-to-mesenchymal transition and the impact of epigenetic alterations in this process are limited...
March 20, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28336199/primary-care-physician-decision-making-regarding-referral-for-bariatric-surgery-a-national-survey
#13
Charlotte Røn Stolberg, Nicola Hepp, Anna Julie Aavild Juhl, Deepti B C, Claus B Juhl
BACKGROUND: Bariatric surgery is the most effective treatment for severe obesity. It results in significant and sustained weight loss and reduces obesity-related co-morbidities. Despite an increasing prevalence of severe obesity, the number of bariatric operations performed in Denmark has decreased during the past years. This is only partly explained by changes in the national guidelines for bariatric surgery. The purpose of the cross-sectional study is to investigate referral patterns and possible reservations regarding bariatric surgery among Danish primary care physicians (PCPs)...
February 4, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28335496/quantitative-analysis-of-the-kshv-transcriptome-following-primary-infection-of-blood-and-lymphatic-endothelial-cells
#14
A Gregory Bruce, Serge Barcy, Terri DiMaio, Emilia Gan, H Jacques Garrigues, Michael Lagunoff, Timothy M Rose
The transcriptome of the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) after primary latent infection of human blood (BEC), lymphatic (LEC) and immortalized (TIME) endothelial cells was analyzed using RNAseq, and compared to long-term latency in BCBL-1 lymphoma cells. Naturally expressed transcripts were obtained without artificial induction, and a comprehensive annotation of the KSHV genome was determined. A set of unique coding sequence (UCDS) features and a process to resolve overlapping transcripts were developed to accurately quantitate transcript levels from specific promoters...
March 19, 2017: Pathogens
https://www.readbyqxmd.com/read/28335324/dna-origami-reorganizes-upon-interaction-with-graphite-implications-for-high-resolution-dna-directed-protein-patterning
#15
Masudur Rahman, David Neff, Nathaniel Green, Michael L Norton
Although there is a long history of the study of the interaction of DNA with carbon surfaces, limited information exists regarding the interaction of complex DNA-based nanostructures with the important material graphite, which is closely related to graphene. In view of the capacity of DNA to direct the assembly of proteins and optical and electronic nanoparticles, the potential for combining DNA-based materials with graphite, which is an ultra-flat, conductive carbon substrate, requires evaluation. A series of imaging studies utilizing Atomic Force Microscopy has been applied in order to provide a unified picture of this important interaction of structured DNA and graphite...
October 31, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334861/defective-signaling-through-plexin-a1-compromises-the-development-of-the-peripheral-olfactory-system-and-neuroendocrine-reproductive-axis-in-mice
#16
Séverine Marcos, Carine Monnier, Xavier Rovira Algans, Corinne Fouveaut, Nelly Pitteloud, Fabrice Ango, Catherine Dodé, Jean-Pierre Hardelin
The olfacto-genital syndrome (Kallmann syndrome) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. This is a genetically heterogeneous developmental disease with various modes of transmission, including oligogenic inheritance. Previous reports have involved defective cell signaling by semaphorin-3A in the disease pathogenesis. Here, we report that the embryonic phenotype of Plxna1-/- mutant mice lacking plexin-A1 (a major receptor of class 3 semaphorins), though not fully penetrant, resembles that of Kallmann syndrome fetuses...
March 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28334611/somatosensory-cortex-plays-an-essential-role-in-forelimb-motor-adaptation-in-mice
#17
Mackenzie Weygandt Mathis, Alexander Mathis, Naoshige Uchida
Our motor outputs are constantly re-calibrated to adapt to systematic perturbations. This motor adaptation is thought to depend on the ability to form a memory of a systematic perturbation, often called an internal model. However, the mechanisms underlying the formation, storage, and expression of such models remain unknown. Here, we developed a mouse model to study forelimb adaptation to force field perturbations. We found that temporally precise photoinhibition of somatosensory cortex (S1) applied concurrently with the force field abolished the ability to update subsequent motor commands needed to reduce motor errors...
March 22, 2017: Neuron
https://www.readbyqxmd.com/read/28334483/activities-of-daily-living-trajectories-among-institutionalized-older-adults-a-prospective-study
#18
Huai-Ting Kuo, Kuan-Chia Lin, Chung-Fu Lan, I-Chuan Li
AIMS AND OBJECTIVES: To examine ADL trajectory groups among older residents in Taiwan, and to determine the relative risks of demographic characteristics and health status in explaining the trajectory group of ADL. BACKGROUND: Activity of daily living (ADL) is a crucial indicator of health status for institutionalized older adults. ADL is a dynamic process, and has differences in trajectory groups. DESIGN: This study was a 3-year longitudinal analysis of long-term care (LTC) facility residents in Taiwan...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28334195/environmental-variables-influence-the-association-of-eustenopus-villosus-and-larinus-curtus-coleoptera-curculionidae-adults-with-different-growth-stages-of-the-invasive-thistle-centaurea-solstitialis-asteraceae-cardueae-in-washington-state
#19
S E Woodley, B A Zamora, T Coffey
A 2-yr (2014-2015) field study in eastern Washington State quantified the effect of environmental factors on the overwintered Eustenopus villosus (Boheman) and Larinus curtus (Hochhut) adults in relation to phenology of Centaurea solstitialis L. (Asteraceae: Cardueae), the feeding and breeding host for these two weevil biocontrol agents. We recorded in the study area: ambient and soil temperatures, soil moisture, percent cover and developmental stage of C. solstitialis, and presence of adults of each weevil species...
March 8, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28334030/measuring-mortality-due-to-hiv-associated-tuberculosis-among-adults-in-south-africa-comparing-verbal-autopsy-minimally-invasive-autopsy-and-research-data
#20
Aaron S Karat, Mpho Tlali, Katherine L Fielding, Salome Charalambous, Violet N Chihota, Gavin J Churchyard, Yasmeen Hanifa, Suzanne Johnson, Kerrigan McCarthy, Neil A Martinson, Tanvier Omar, Kathleen Kahn, Daniel Chandramohan, Alison D Grant
BACKGROUND: The World Health Organization (WHO) aims to reduce tuberculosis (TB) deaths by 95% by 2035; tracking progress requires accurate measurement of TB mortality. International Classification of Diseases (ICD) codes do not differentiate between HIV-associated TB and HIV more generally. Verbal autopsy (VA) is used to estimate cause of death (CoD) patterns but has mostly been validated against a suboptimal gold standard for HIV and TB. This study, conducted among HIV-positive adults, aimed to estimate the accuracy of VA in ascertaining TB and HIV CoD when compared to a reference standard derived from a variety of clinical sources including, in some, minimally-invasive autopsy (MIA)...
2017: PloS One
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