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https://www.readbyqxmd.com/read/29778000/anxiety-moderates-the-effects-of-stressor-controllability-and-cognitive-reappraisal-on-distress-following-aversive-exposure-an-experimental-investigation
#1
Lillian Le, Michelle Moulds, Angela Nickerson
BACKGROUND AND OBJECTIVES: Emerging evidence suggests that the effectiveness of cognitive reappraisal (CR) depends on different factors, including the individual's psychological wellbeing (e.g., level of anxiety) and the context in which the strategy is used (e.g., stressor controllability). The present study aimed to investigate the emotional (negative affect) and physiological (skin conductance levels) effects of emotion regulation following exposure to controllable versus uncontrollable stress...
May 8, 2018: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29777846/an-academic-tertiary-referral-center-s-experience-with-a-vascular-surgery-based-uterine-artery-embolization-program
#2
Naiem Nassiri, Adrian Balica, Nolan C Cirillo-Penn, Dustin Tyler Crystal, Gloria A Bachmann
OBJECTIVE: Despite growing endovascular experience within the vascular surgery community, some catheter-based interventions - such as uterine artery embolization (UAE) - remain outside the clinical scope of most vascular surgeons, owing in part to established referral patterns and limited awareness among referring colleagues. We present our experience with a vascular surgery-based, multidisciplinary UAE program at an academic tertiary referral center. METHODS: In a collaborative effort between vascular surgery and gynecology, a Pelvic Vascular Disease Program has been established to provide palliative, prophylactic, and therapeutic embolizations including, but not limited to, UAE...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777767/biglycan-is-a-new-high-affinity-ligand-for-cd14-in-macrophages
#3
Heiko Roedig, Madalina V Nastase, Helena Frey, Kristin Moreth, Jinyang Zeng-Brouwers, Chiara Poluzzi, Louise Tzung-Harn Hsieh, Christian Brandts, Simone Fulda, Malgorzata Wygrecka, Liliana Schaefer
Sterile inflammation is a therapeutic target in many diseases where it represents an important initiator of disease progression. However, the detailed mechanisms underlying its evolution and biological relevance are not yet completely elucidated. Biglycan, a prototype extracellular matrix-derived damage-associated molecular pattern, mediates sterile inflammation in macrophages through Toll-like receptor (TLR) 2 and/or TLR4-dependent signaling pathways. Here we discovered that soluble biglycan is a novel high-affinity ligand for CD14, a well-known GPI-anchored co-receptor for TLRs...
May 16, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29777713/development-and-psychometric-validation-of-capacity-assessment-of-prosthetic-performance-for-the-upper-limb-cappful
#4
Nathan T Kearns, Jennifer K Peterson, Lisa Smurr Walters, Warren T Jackson, John M Miguelez, Tiffany Ryan
OBJECTIVES: (1) Develop a performance-based measure for adult upper limb (UL) prosthetic functioning through broad (i.e. overall performance) and functional domain-specific (e.g., control skills) assessment of commonplace activities; (2) conduct initial psychometric evaluation of the Capacity Assessment of Prosthetic Performance for the Upper Limb (CAPPFUL). DESIGN: Internal consistency of CAPPFUL and interrater reliability for task, functional domain, and full scale (sub)scores among three independent raters were estimated...
May 16, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29777477/cardiac-and-gait-rhythms-in-healthy-younger-and-older-adults-during-treadmill-walking-tasks
#5
Matthew W Wittstein, Joseph M Starobin, Randy J Schmitz, Sandra J Shulz, Francis Jay Haran, Christopher K Rhea
BACKGROUND: Aging and pathology result in changes in the dynamics of several physiological subsystems. Often, these changes are concurrent, altering the dynamics between subsystems. Cardiac and gait rhythms are one example in which patterns change during physical activity. AIMS: The purpose of this research is to simultaneously monitor changes in cardiac and gait rhythms when participants complete various treadmill walking tasks-normal speed, fast speed, and while synchronizing steps with a blinking metronome...
May 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29777369/adherence-to-special-diets-and-its-association-with-meeting-the-nutrient-recommendations-in-individuals-with-type-1-diabetes
#6
A J Ahola, C Forsblom, Per-Henrik Groop
AIMS: Not much is known about adherence to special diets in type 1 diabetes, characteristics of individuals with special diets, and whether such practices should raise concerns with respect to meeting the dietary recommendations. In this study, we assessed the frequencies of adherence to special diets, in a population of individuals with type 1 diabetes, and investigated the association between special diet adherence and dietary intake, measured as dietary patterns and nutrient intakes...
May 18, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29776429/assessing-adhd-symptoms-in-children-and-adults-evaluating-the-role-of-objective-measures
#7
Theresa S Emser, Blair A Johnston, J Douglas Steele, Sandra Kooij, Lisa Thorell, Hanna Christiansen
BACKGROUND: Diagnostic guidelines recommend using a variety of methods to assess and diagnose ADHD. Applying subjective measures always incorporates risks such as informant biases or large differences between ratings obtained from diverse sources. Furthermore, it has been demonstrated that ratings and tests seem to assess somewhat different constructs. The use of objective measures might thus yield valuable information for diagnosing ADHD. This study aims at evaluating the role of objective measures when trying to distinguish between individuals with ADHD and controls...
May 18, 2018: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/29776339/differential-gene-transcription-across-the-life-cycle-in-daphnia-magna-using-a-new-all-genome-custom-made-microarray
#8
Bruno Campos, Danielle Fletcher, Benjamín Piña, Romà Tauler, Carlos Barata
BACKGROUND: Unravelling the link between genes and environment across the life cycle is a challenging goal that requires model organisms with well-characterized life-cycles, ecological interactions in nature, tractability in the laboratory, and available genomic tools. Very few well-studied invertebrate model species meet these requirements, being the waterflea Daphnia magna one of them. Here we report a full genome transcription profiling of D. magna during its life-cycle. The study was performed using a new microarray platform designed from the complete set of gene models representing the whole transcribed genome of D...
May 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29776168/electrohydrodynamic-coalescence-of-droplets-using-an-embedded-potential-flow-model
#9
M Garzon, L J Gray, J A Sethian
The coalescence, and subsequent satellite formation, of two inviscid droplets is studied numerically. The initial drops are taken to be of equal and different sizes, and simulations have been carried out with and without the presence of an electrical field. The main computational challenge is the tracking of a free surface that changes topology. Coupling level set and boundary integral methods with an embedded potential flow model, we seamlessly compute through these singular events. As a consequence, the various coalescence modes that appear depending upon the relative ratio of the parent droplets can be studied...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775472/spatial-pattern-and-determinants-of-anaemia-in-ethiopia
#10
Bedilu Alamirie Ejigu, Eshetu Wencheko, Kiros Berhane
Anaemia is a condition in which the haemoglobin concentration falls below an established cut-off value due to a decrease in the number and size of red blood cells. The current study aimed (i) to assess the spatial pattern and (ii) to identify determinants related to anaemia using the third Ethiopian demographic health survey. To achieve these objectives, this study took into account the sampling weight and the clustered nature of the data. As a result, multilevel modeling has been used in the statistical analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29775060/distinct-populations-in-spin-label-epr-spectra-from-nitroxides
#11
Derek Marsh
It is not possible to reproduce simulations of nitroxide spin-label EPR spectra published in J. Phys. Chem. 88, 3454-3465 (1984), when using the motional model and parameters given in that paper. Instead of the apparent two-component line shapes claimed, the spectra resemble single-component powder patterns expected from axially anisotropic, partial motional-averaging (a situation familiar for chain-labelled lipids in nonaligned fluid membranes). This is because: (i) the nitroxide z-axis is inclined at a fixed angle to the principal diffusion axis, and (ii) motion perpendicular to the principal diffusion axis is so slow as to approximate a powder distribution...
May 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29774594/in-vivo-characterization-of-3d-skull-and-brain-motion-during-dynamic-head-vibration-using-magnetic-resonance-elastography
#12
Ziying Yin, Yi Sui, Joshua D Trzasko, Phillip J Rossman, Armando Manduca, Richard L Ehman, John Huston
PURPOSE: To introduce newly developed MR elastography (MRE)-based dual-saturation imaging and dual-sensitivity motion encoding schemes to directly measure in vivo skull-brain motion, and to study the skull-brain coupling in volunteers with these approaches. METHODS: Six volunteers were scanned with a high-performance compact 3T-MRI scanner. The skull-brain MRE images were obtained with a dual-saturation imaging where the skull and brain motion were acquired with fat- and water-suppression scans, respectively...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29774201/investigation-of-experimental-factors-that-underlie-brca1-2-mrna-isoform-expression-variation-recommendations-for-utilizing-targeted-rna-sequencing-to-evaluate-potential-spliceogenic-variants
#13
Vanessa L Lattimore, John F Pearson, Margaret J Currie, Amanda B Spurdle, Bridget A Robinson, Logan C Walker
PCR-based RNA splicing assays are commonly used in diagnostic and research settings to assess the potential effects of variants of uncertain clinical significance in BRCA1 and BRCA2 . The Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium completed a multicentre investigation to evaluate differences in assay design and the integrity of published data, raising a number of methodological questions associated with cell culture conditions and PCR-based protocols. We utilized targeted RNA-seq to re-assess BRCA1 and BRCA2 mRNA isoform expression patterns in lymphoblastoid cell lines (LCLs) previously used in the multicentre ENIGMA study...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29774036/the-pattern-and-distribution-of-induced-mutations-in-j-curcas-using-reduced-representation-sequencing
#14
Fatemeh Maghuly, Stephan Pabinger, Julie Krainer, Margit Laimer
Mutagenesis in combination with Genotyping by Sequencing (GBS) is a powerful tool for introducing variation, studying gene function and identifying causal mutations underlying phenotypes of interest in crop plant genomes. About 400 million paired-end reads were obtained from 82 ethylmethane sulfonate (EMS) induced mutants and 14 wild-type accessions of Jatropha curcas for the detection of Single Nucleotide Polymorphisms (SNPs) and Insertion/Deletions (InDels) by two different approaches (nGBS and ddGBS) on an Illumina HiSeq 2000 sequencer...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29773679/comparative-proteomic-analysis-reveals-the-regulatory-network-of-the-vea-gene-during-asexual-and-sexual-spore-development-of-aspergillus-cristatus
#15
Hui Liu, Shilei Sang, Hui Wang, Xiyi Ren, Yumei Tan, Wei Chen, Zuoyi Liu, Yongxiang Liu
Aspergillus cristatus belongs to the homothallic fungal group that undergoes a sexual stage without asexual conidiation under hypotonic conditions, while hypertonic medium induces initiation of the asexual stage and completely blocks sexual development. However, the veA deletion mutant only produces conidia in hypotonic medium after a 24 h culture, but both asexual and sexual spores are observed after 72 h. To elucidate the molecular mechanism of how VeA regulates asexual and sexual spore development in A. cristatus , two dimensional electrophoresis combined with matrix-assisted laser desorption/ionization-tandem time of flight mass spectrometry analysis were applied to identify 173 differentially expressed proteins (DEPs) by comparing the agamotype (24 h) and teleomorph (72 h) with wild-type A...
May 17, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29773316/rapid-recovery-of-a-coral-dominated-eastern-tropical-pacific-reef-after-experimentally-produced-anthropogenic-disturbance
#16
Ranjan Muthukrishnan, Peggy Fong
Local anthropogenic stressors such as overfishing, nutrient enrichment and increased sediment loading have been shown to push coral reefs toward greater dominance by algae. In a few cases this shift has been temporary, with the ability to recover to a healthy coral-dominated community after disturbance, suggesting some systems have considerable resilience. However, an understanding of the circumstances under which reefs may recover is only beginning to emerge. We monitored recovery of a coral-dominated reef in the Eastern Tropical Pacific (ETP) after cessation of a ∼6 month multiple stressor experiment (with herbivore exclosure, nutrient addition, and sediment addition)...
May 7, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29772217/altered-activity-and-information-flow-in-the-default-mode-network-of-pilocarpine-induced-epilepsy-rats
#17
Yan Cui, Shuang Yu, Tianjiao Zhang, Yangsong Zhang, Yang Xia, Dezhong Yao, Daqing Guo
Temporal lobe epilepsy (TLE) is considered a brain activity disorder that is likely related to allomnesia and conscious disturbance. In rodents, TLE epileptiform discharges can be triggered by systemic administration of a dose of pilocarpine. However, how these pilocarpine-induced epileptiform discharges generate and propagate through the whole brain has not been well studied. In this study, we sought to assess alterations of activity and information flow in the default mode network (DMN) during TLE epileptiform discharges in pilocarpine-induced TLE rats...
May 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29771902/the-impact-of-different-tumour-subtypes-on-management-and-survival-of-new-zealand-women-with-stage-i-iii-breast-cancer
#18
Ross Lawrenson, Chunhuan Lao, Ian Campbell, Vernon Harvey, Sanjeewa Seneviratne, Mark Elwood, Diana Sarfati, Marion Kuper-Hommel
AIMS: This study aims to describe the prevalence and characteristics of the different ER/PR/HER2 subtypes in New Zealand women with breast cancer, and to explore their treatment and outcomes. METHODS: This study included women diagnosed with Stage I-III breast cancer between January 2006 and May 2013, recorded in the combined Waikato and Auckland Breast Cancer Registers, and with complete data on their ER, PR and HER2 status. Five ER/PR/HER2 phenotypes were classified...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29771898/symptoms-of-bowel-dysfunction-and-their-management-after-spinal-cord-injury-in-a-new-zealand-centre
#19
Edwin P Arnold, Giovanni Losco, Sharon English, Frank Frizelle, Angelo Anthony
AIM: To document the symptoms of bowel dysfunction, and how the bowels are managed, in a cohort of patients following a spinal cord injury. To relate these to the level of the spinal injury and to examine the relationship between bowel symptoms and bladder dysfunction. METHOD: Participants were identified from the discharge data from the Burwood Spinal Unit, one of two national Spinal Units in New Zealand, in two two-year sets from 1-3 years post-injury and from 20-21 years post-injury...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29771775/photodynamic-therapy-for-bronchial-microscopic-residual-disease-after-resection-in-lung-cancer
#20
Hiren J Mehta, Abhishek Biswas, Sebastian Fernandez-Bussy, Mauricio Pipkin, Tiago Machuca, Michael A Jantz
BACKGROUND: The goal of lung cancer surgery is a complete tumor resection (R0 resection) with clear margins. 4% to 5% of resections have microscopic residual disease associated with worse prognosis. Definitive management is resection of residual tumor, which may not be tolerated by many patients, and definitive management is not well studied in these patients. We treated patients with stage I cancer and bronchial mucosal residual disease (MRD) with bronchoscopic photodynamic therapy (PDT)...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
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