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Ohio state university

Stephen D Thorpe, Myriam Charpentier
The last decade has seen rapid advances in our understanding of the proteins of the nuclear envelope, which have multiple roles including positioning the nucleus, maintaining its structural organisation, and in events ranging from mitosis and meiosis to chromatin positioning and gene expression. Diverse new and stimulating results relating to nuclear organisation and genome function from across kingdoms were presented in a session stream entitled "Dynamic Organisation of the Nucleus" at this year's Society of Experimental Biology (SEB) meeting in Brighton, UK (July 2016)...
October 7, 2016: Nucleus
Lalitha Sivaswamy
Investigators from the Ohio State University, Oregon Health and Science University and Rosalind Franklin School of Medicine examined the presenting manifestations, demographics and treatment strategies in children enrolled in the Intracranial Hypertension Registry (IHR).
October 2016: Pediatric neurology briefs
M Taberna, C Resteghini, B Swanson, R K L Pickard, B Jiang, W Xiao, M Mena, P Kreinbrink, E Chio, M L Gillison
BACKGROUND: Human Papillomavirus (HPV) is a cause of oropharyngeal squamous cell carcinoma (OPSCC), but its pathogenic role in larynx squamous cell carcinoma (LSCC) remains unclear. MATERIAL AND METHODS: A single-institutional, retrospective case-series was performed to estimate the etiological fraction (EF) for HPV in LSCC. Eligible cases included 436 consecutive cases of LSCC diagnosed (2005-2014) at The Ohio State University Medical Center. HPV DNA presence was detected by consensus primer PCR (Inno-LiPa) and HPV type-specific qPCR...
October 2016: Oral Oncology
Quinn Capers, Daniel Clinchot, Leon McDougle, Anthony G Greenwald
PROBLEM: Implicit white race preference has been associated with discrimination in the education, criminal justice, and health care systems and could impede the entry of African Americans into the medical profession, where they and other minorities remain underrepresented. Little is known about implicit racial bias in medical school admissions committees. APPROACH: To measure implicit racial bias, all 140 members of the Ohio State University College of Medicine (OSUCOM) admissions committee took the black-white implicit association test (IAT) prior to the 2012-2013 cycle...
September 27, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
C L Pickworth, L M Bell, W Greene, C S Whisnant, D H Poole
Beef Quality Assurance programs have contributed to significant improvements in the wholesomeness of beef available for consumption. Injection site blemishes in the round have declined since the promotion of administering intramuscular injections in the neck. Unfortunately, many producers continue to administer estrus synchronization (ES) drugs in the rump. The objective of this study was to compare the effectiveness of injection site of PGF2α, in ES protocols, on steroid hormone concentrations and pregnancy rates...
August 27, 2016: Theriogenology
Jennifer L Hefner, Ravi S Tripathi, Erik E Abel, Michelle Farneman, Jason Galloway, Susan D Moffatt-Bruce
BACKGROUND: In 2010, the incidence of prolonged mechanical ventilation (> 24 hours) after isolated coronary artery bypass graft (CABG) surgery was 26.9% at the study site, The Ohio State University Wexner Medical Center, compared with the national like-hospital rate of 10.9%. OBJECTIVES: To use the principles of lean management to reduce the incidence of prolonged mechanical ventilation and to assess the sustainability of that reduction over time. METHODS: A multidisciplinary prolonged ventilation task force conducted a gap analysis leading to 3 interventions: (1) a standardized extubation protocol, (2) dry erase boards in patients' rooms to facilitate team communication, and (3) edits of the postoperative order set within the electronic health record...
September 2016: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
Alexis B Peterson, R Matthew Gladden, Chris Delcher, Erica Spies, Amanda Garcia-Williams, Yanning Wang, John Halpin, Jon Zibbell, Carolyn Lullo McCarty, Jolene DeFiore-Hyrmer, Mary DiOrio, Bruce A Goldberger
In March and October 2015, the Drug Enforcement Administration (DEA) and CDC issued nationwide alerts identifying fentanyl, particularly illicitly manufactured fentanyl (IMF), as a threat to public health and safety (1,2). IMF is pharmacologically similar to pharmaceutical fentanyl (PF), but is unlawfully produced in clandestine laboratories, obtained via illicit drug markets, and includes fentanyl analogs. Fentanyl is a synthetic opioid 50-100 times more potent than morphine and approved for the management of surgical/postoperative pain, severe chronic pain, and breakthrough cancer pain...
2016: MMWR. Morbidity and Mortality Weekly Report
Reena Oza-Frank, Jennifer J Moreland, Kelly McNamara, Sheela R Geraghty, Sarah A Keim
BACKGROUND: Detailed data on lactation practices by gestational diabetes mellitus (GDM) history are lacking, precluding potential explanations and targets for interventions to improve lactation intensity and duration and, ultimately, long-term maternal and child health. OBJECTIVE: This study aimed to examine breastfeeding practices through 12 months postpartum by GDM history. METHODS: Women who delivered a singleton, liveborn infant at The Ohio State University Wexner Medical Center (Columbus, OH), in 2011 completed a postal questionnaire to assess lactation and infant feeding practices and difficulties...
August 22, 2016: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Brynn Hollingsworth, Leigha Senter, Xiaoli Zhang, Guy N Brock, Wael Jarjour, Rebecca Nagy, Pamela Brock, Kevin R Coombes, Richard Kloos, Matthew D Ringel, Jennifer Sipos, Ilene Lattimer, Ricardo Carrau, Sissy M Jhiang
CONTEXT: Sialadenitis and xerostomia are major adverse effects of (131)I therapy in thyroid cancer patients. The risk factors for these adverse effects, other than administered activity of (131)I, have not been investigated. OBJECTIVE: The aim of this study is to identify risk factors for (131)I-induced salivary gland damage among follicular cell-derived thyroid cancer patients. DESIGN: We enrolled 216 thyroid cancer patients who visited The Ohio State University Wexner Medical Center between April 2013 and April 2014...
August 17, 2016: Journal of Clinical Endocrinology and Metabolism
Derek B Allison, Paul E Wakely, Momin T Siddiqui, Syed Z Ali
BACKGROUND: Nodular fasciitis (NF) is a benign, self-limited, fibroblastic/myofibroblastic proliferation that is diagnostically challenging, often mimicking a malignant process due to its rapid growth clinically and its high cellularity, mitotic activity, and variable/nonspecific cytomorphologic findings. Herein, the authors report what to their knowledge is the largest and first multi-institutional study of the cytomorphologic characteristics of NF by fine-needle aspiration (FNA). METHODS: The pathology archives at The Johns Hopkins Hospital, The Ohio State University Wexner Medical Center, and Emory University Hospital were searched for soft tissue FNA cytology specimens of masses confirmed to be NF...
August 15, 2016: Cancer Cytopathology
David S Strosberg, Kristen M Quinn, Sherif R Abdel-Misih, Alan E Harzman
OBJECTIVE: Junior surgical resident education at academic institutions is traditionally focused to preoperative and postoperative patient management. Our objective was to investigate the number and type of surgical procedures performed by junior general surgery residents in comparison with the American Board of Surgery requirements and the Surgical Council on Resident Education (SCORE) curriculum. DESIGN: This was a retrospective study using the Accreditation Counsel for Graduate Medical Education (ACGME) operative case logs of junior surgical residents...
August 8, 2016: Journal of Surgical Education
Randi E Foraker, Abigail B Shoben, Marjorie M Kelley, Albert M Lai, Marcelo A Lopetegui, Rebecca D Jackson, Michael A Langan, Philip R O Payne
< 3% of Americans have ideal cardiovascular health (CVH). The primary care encounter provides a setting in which to conduct patient-provider discussions of CVH. We implemented a CVH risk assessment, visualization, and decision-making tool that automatically populates with electronic health record (EHR) data during the encounter in order to encourage patient-centered CVH discussions among at-risk, yet under-treated, populations. We quantified five of the seven CVH behaviors and factors that were available in The Ohio State University Wexner Medical Center's EHR at baseline (May-July 2013) and compared values to those ascertained at one-year (May-July 2014) among intervention (n = 109) and control (n = 42) patients...
December 2016: Preventive Medicine Reports
C S Allely
OBJECTIVES: The primary objectives of the present systematic PRISMA review were: (1) to explore the range of prevalence of TBI in offenders and whether this is higher than in a control sample; (2) to determine which screening measures are available and evaluate the evidence on these; and, lastly, (3) to evaluate whether prevalence of TBI is associated with increased prevalence of other health conditions and/or offending behaviour. METHODS: The present systematic PRISMA review explores the peer-reviewed literature published since 2005 which has investigated TBI in incarcerated populations using five databases (CINAHL, MEDLINE, PsycARTICLES, Psychology and Behavioral Sciences Collection, PsycINFO) in addition to separate searches conducted on 'Google Scholar' using specific search criteria...
2016: Brain Injury: [BI]
Gregory J McHugo, Sarah Krassenbaum, Sachiko Donley, John D Corrigan, Jennifer Bogner, Robert E Drake
OBJECTIVE: To estimate the rate and severity of traumatic brain injury (TBI) among people with co-occurring mental health and substance use disorders and to compare demographic, diagnostic, and institutionalization differences between those who screen positive or negative. SETTING: Outpatient community mental health center in Washington, District of Columbia. PARTICIPANTS: A total of 295 people with co-occurring mental health and substance use disorders enrolled in a prospective study of integrated treatment of substance abuse...
July 21, 2016: Journal of Head Trauma Rehabilitation
Shikha Jain Goodwin
Ohio State University researchers have made a leap forward in disease research by creating an eraser sized human "brain" in a petri dish(1). Although lacking a circulatory system their brain model includes spinal cord, cortex, midbrain, brain stem, and even the beginnings of an eye- aiding in the effectiveness of research on complex neurological disease. To create their new brain model, the researchers converted adult skin cells into pluripotent stem cells, which afforded the opportunity to build the multiple nervous cell types required for such a complex system...
November 2015: Postdoc Journal: a Journal of Postdoctoral Research and Postdoctoral Affairs
Trisha A Jordan, Joel A Hennenfent, John J Lewin, Todd W Nesbit, Robert Weber
PURPOSE: The privileging of pharmacists for clinical activities and the impact that privileging has on enhancing the scope of pharmacy practice in health systems are reviewed. SUMMARY: Health-system pharmacists or pharmacy leaders must gain a thorough understanding of the credentialing and privileging process as they broaden their scope of practice. Clinical privileging affords an expanded scope of practice that is recognized at the institutional level and formally elevates the pharmacist to that of a nonphysician provider...
September 15, 2016: American Journal of Health-system Pharmacy: AJHP
P L Poole, C Willis, R L Daskalova, K M George, S Feister, S Jiang, J Snyder, J Marketon, D W Schumacher, K U Akli, L Van Woerkom, R R Freeman, E A Chowdhury
We report on the recently completed 400 TW upgrade to the Scarlet laser at The Ohio State University. Scarlet is a Ti:sapphire-based ultrashort pulse system that delivers >10  J in 30 fs pulses to a 2 μm full width at half-maximum focal spot, resulting in intensities exceeding 5×10<sup>21</sup>  W/cm<sup>2</sup>. The laser fires at a repetition rate of once per minute and is equipped with a suite of on-demand and on-shot diagnostics detailed here, allowing for rapid collection of experimental statistics...
June 10, 2016: Applied Optics
Rachel M Roth, Sigurdis Haraldsdottir, Heather Hampel, Christina A Arnold, Wendy L Frankel
OBJECTIVES: Lynch syndrome (LS) predisposes individuals to developing synchronous and metachronous LS-associated neoplasms (LSANs). Mismatch repair protein (MMRP) immunohistochemistry (IHC) is widely used to identify LS, but its utility in patients with synchronous/metachronous lesions has not been studied. We studied MMRP IHC in patients with LS with more than one LSAN to provide screening recommendations in patients with synchronous/metachronous neoplasms. METHODS: All patients with LS diagnosed at The Ohio State University Wexner Medical Center from 2009 through 2014 with more than one LSAN and available tumor tissue for immunostaining were identified...
July 2016: American Journal of Clinical Pathology
Elliott D Crouser, Emily Ruden, Mark W Julian, Subha V Raman
Cardiac MR (CMR) with late gadolinium enhancement is commonly used to detect cardiac damage in the setting of cardiac sarcoidosis. The addition of T2 mapping to CMR was recently shown to enhance cardiac sarcoidosis detection and correlates with increased cardiac arrhythmia risk. This study was conducted to determine if CMR T2 abnormalities and related arrhythmias are reversible following immune suppression therapy. A retrospective study of subjects with cardiac sarcoidosis with abnormal T2 signal on baseline CMR and a follow-up CMR study at least 4 months later was conducted at The Ohio State University from 2011 to 2015...
August 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Carrie B Peltz, Raquel C Gardner, Kimbra Kenney, Ramon Diaz-Arrastia, Joel H Kramer, Kristine Yaffe
OBJECTIVE: While traumatic brain injury (TBI) is common across the life span, the detailed neurobehavioral characteristics of older adults with prior TBI remain unclear. Our goal was to compare the clinical profile of older independently living veterans with and without prior TBI. SETTING: Two veterans' retirement communities. PARTICIPANTS: Seventy-five participants with TBI and 71 without (mean age = 78 years). DESIGN: Cross-sectional...
June 17, 2016: Journal of Head Trauma Rehabilitation
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