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https://www.readbyqxmd.com/read/29788089/the-relationship-between-traumatic-brain-injury-and-rates-of-chronic-symptomatic-illness-in-202-gulf-war-veterans
#1
Linda L Chao
Introduction: Although not a "signature injury" of Operation Desert Shield/Desert Storm (i.e., Gulf War, GW), some GW veterans have a history traumatic brain injury (TBI). For example, a previous study found that 12.2% of the GW veterans from the Fort Devens Cohort Study had self-reported TBIs. The present study sought to build upon this finding by examining the relationship between TBI and chronic symptomatic illness in a different sample of GW veterans. Materials and Methods: Participants were 202 GW veterans recruited from 2014 to 2018 at the San Francisco Veterans Affairs Medical Center as part of a VA-funded study on the effects of predicted exposure to low levels of sarin and cyclosarin on brain structure and function...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29727492/first-person-john-byrd-md-this-ohio-state-university-researcher-has-been-developing-transformative-treatments-for-patients-with-chronic-lymphocytic-leukemia-and-now-is-setting-his-sights-on-individuals-with-acute-myeloid-leukemia
#2
https://www.readbyqxmd.com/read/29723603/histology-of-colorectal-adenocarcinoma-with-double-somatic-mismatch-repair-mutations-is-indistinguishable-from-those-caused-by-lynch-syndrome
#3
Jessica A Hemminger, Rachel Pearlman, Sigurdis Haraldsdottir, Deborah Knight, Jon Gunnlaugur Jonasson, Colin C Pritchard, Heather Hampel, Wendy L Frankel
Lynch syndrome (LS) is the most common form of hereditary colon cancer (CRC). Germline mutations in the mismatch repair (MMR) genes MLH1, MSH2 (EPCAM), MSH6, and PMS2, followed by a second hit to the remaining allele leads to cancer development. Universal tumor screening for LS is routinely performed on CRC, and screening has identified patients with unexplained MMR deficiency that lack MLH1 methylation and a germline mutation. Tumor sequencing has since identified double somatic (DS) mutations in the MMR gene corresponding with the absent protein in 69% of these patients...
April 30, 2018: Human Pathology
https://www.readbyqxmd.com/read/29709522/feasibility-and-preliminary-validation-of-an-online-version-of-the-ohio-state-university-traumatic-brain-injury-identification-method
#4
Anthony H Lequerica, Christian Lucca, Nancy D Chiaravalloti, Irene Ward, John D Corrigan
OBJECTIVE: To test the feasibility and validity of an online version of an established interview designed to determine a lifetime history of traumatic brain injury. DESIGN: Cross-sectional SETTING: General community PARTICIPANTS: A volunteer sample of 265 individuals from the general population across the U.S. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURE(S): Online version of the Ohio State University Traumatic Brain Injury Identification Method, Rivermead Postconcussion Symptoms Questionnaire (RPQ), PROMIS Cognitive Concerns Scale RESULTS: The measure was completed by 89...
April 27, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29683125/factors-associated-with-poor-sleep-in-older-women-diagnosed-with-breast-cancer
#5
Janine Overcash, Alai Tan, Keya Patel, Anne M Noonan
OBJECTIVES: To determine the relationship among gait, grip strength, cognition, depression, pain, and fatigue, and to identify which variables are most predictive of poor sleep. SAMPLE & SETTING: 60 women with breast cancer aged 69 years or older who were receiving treatment in the Senior Adult Oncology Program at the James Cancer Hospital at the Ohio State University. METHODS & VARIABLES: The variables were gait and grip strength (functional domains), cognition, depression, pain, and fatigue...
May 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29679599/mortality-in-pulmonary-arterial-hypertension-patients-treated-with-continuous-prostanoids
#6
S D Bartolome, N Sood, T S Shah, K Styrvoky, F T Torres, K M Chin
INTRODUCTION: Parenteral prostanoids are considered the treatment of choice for patients with severe pulmonary arterial hypertension (PAH). Prognostic studies for patients treated in the modern era are limited. METHODS: In this retrospective cohort study, patients initiating IV epoprostenol or IV or SC treprostinil therapy for PAH from 2007-2016 at UT Southwestern, Dallas, TX and Ohio State University, Columbus, OH were included. Transplant-free survival was assessed from the time of IV/SC initiation and from the time of first follow-up...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29651918/updated-report-on-incidence-of-infusion-site-reactions-associated-with-peripheral-intravenous-administration-of-fosaprepitant
#7
Eric Chau, Jordan Lundberg, Gary Phillips, Michael Berger, Robert Wesolowski
Purpose Fosaprepitant (Emend®) is an antiemetic frequently used for the prevention of chemotherapy-induced nausea and vomiting. We previously documented an overall 28.7% incidence of infusion-site reactions in patients receiving fosaprepitant via peripheral venous access. These data resulted in a practice change within our institution; fosaprepitant is administered in more dilute concentrations over 30 min to prevent these adverse events. This retrospective study explored the impact of this practice change on the incidence of infusion-site reactions...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29611769/predictors-of-complications-in-patients-receiving-head-and-neck-free-flap-reconstructive-procedures
#8
Antoine Eskander, Stephen Kang, Ben Tweel, Jigar Sitapara, Matthew Old, Enver Ozer, Amit Agrawal, Ricardo Carrau, James W Rocco, Theodoros N Teknos
Objective To (1) determine the overall complication rate, wound healing, and wound infection complications and (2) identify preoperative, intraoperative, and postoperative predictors of these complications. Study Design Case series with chart review. Setting Tertiary academic cancer hospital. Subjects and Methods All head and neck free flap patients at The Ohio State University (2006-2012) were assessed. Multivariable logistic regression assessed the impact of patient factors, flap and wound factors, and intraoperative factors on the aforementioned quality metric outcomes...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29606997/characterization-of-the-2016-2017-dermatology-standardized-letter-of-recommendation
#9
Rebecca F Wang, Myron Zhang, Allireza Alloo, Thomas Stasko, Jordan E Miller, Jessica A Kaffenberger
Objective: We aimed to analyze the reformatted standard letter of recommendation (SLOR) for dermatology residents to examine trends in grading and content based on the positions of the letter writers, their backgrounds, and their relationship with the applicant, as well as to evaluate the SLOR's ability to discriminate applicants. Design: This was a retrospective characterization study of dermatology SLORs from the 2016-17 application cycle. Setting: We examined SLORs received by The Ohio State University, the University of Oklahoma, and Hofstra University Northwell Health dermatology residency programs...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29589978/zap70-expression-enhances-chemokine-driven-chronic-lymphocytic-leukemia-cell-migration-and-arrest-by-valency-regulation-of-integrins
#10
Julia M Laufer, Ruth Lyck, Daniel F Legler
The ζ-associated protein of 70 kDa (ZAP70) is expressed in the aggressive form of B-cell chronic lymphocytic leukemia (CLL). Moreover, the integrin very late antigen (VLA)-1 is highly expressed on subtypes of CLL that are associated with high proliferation rates in the lymph node context. We herein identify a critical role for ZAP70 in chemokine-mediated, inside-out signaling to integrins in trisomy 12 carrying Ohio State University-CLL cell lines derived from a patient with previously treated CLL. We found that ZAP70-positive CLL cells migrated significantly better toward ligands of the lymph node homing chemokine receptors CCR7 and CXCR4 compared with ZAP70-negative cells...
March 28, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29582708/peritoneal-and-scrotal-carcinomas-of-unknown-origin-in-two-bovine-calves
#11
Kelsey A Brakel, Grace VanHoy, Austin Hinds, Justin Breitbach, Christopher Premanandan, Rebecca Kohnken
Two unrelated bovine beef calves, aged 2 mo and 3 mo, were presented to The Ohio State University Veterinary Medical Center because of scrotal swelling and abdominal distension. On postmortem examination, there was abundant peritoneal fluid and numerous small friable masses covering all peritoneal surfaces and extending into the scrotum via the tunica vaginalis, with no identifiable primary neoplasm. Based on light microscopy, differential diagnoses included malignant mesothelioma and anaplastic carcinoma. Immunohistochemically, the neoplasms labeled positive for cytokeratin, and negative for vimentin and calretinin...
March 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29505144/computed-tomography-measured-psoas-density-predicts-outcomes-after-enterocutaneous-fistula-repair
#12
Wilson D Lo, David C Evans, Taehwan Yoo
BACKGROUND: Low muscle mass and quality are associated with poor surgical outcomes. We evaluated computed tomography (CT)-measured psoas muscle density as a marker of muscle quality and physiologic reserve and hypothesized that it predicts poor outcomes after enterocutaneous fistula repair (ECF). METHODS: We conducted a retrospective cohort study of patients 18-90 years old with ECF who failed nonoperative management, requiring elective operative repair at The Ohio State University (2005-2016), and who received preoperative abdomen/pelvis CT scan with intravenous contrast within 3 months of the operation...
January 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29471965/early-experience-with-a-combined-surgical-and-obstetrics-gynecology-clerkship-we-do-get-along
#13
Sherif Abdel-Misih, Nicole Verbeck, Curtis Walker, Wanjiku Musindi, Katherine Strafford, Lori Meyers, Kimberly Tartaglia, Alan Harzman
BACKGROUND: In 2012, the Ohio State University College of Medicine (OSUCOM) implemented a new undergraduate medical curriculum. We compare outcomes of a third year traditional clerkship format to a combined Surgery and Obstetrics/Gynecology 'ring'. METHODS: Performance outcomes of 4 consecutive classes were compared between pre- (2014, 2015) and post-curricular revision (2016, 2017). RESULTS: Three hundred ninety-one students consented use of their educational data for research...
February 16, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29460705/a-single-center-retrospective-cohort-study-comparing-low-molecular-weight-heparins-to-direct-oral-anticoagulants-for-the-treatment-of-venous-thromboembolism-in-patients-with-cancer-a-real-world-experience
#14
Megan K Phelps, Tracy E Wiczer, H Paige Erdeljac, Kelsey R Van Deusen, Kyle Porter, Gary Philips, Tzu-Fei Wang
Introduction Low-molecular-weight heparins are the standard treatment for cancer-associated thrombosis. Recently, direct oral anticoagulants are a new option for thrombosis treatment; however, data supporting the use of direct oral anticoagulants for cancer-associated thrombosis are limited. Objectives The primary objective of this study was to determine the rate of recurrent cancer-associated thrombosis and major bleeding within 6 months of starting either low-molecular-weight heparin or direct oral anticoagulant for treatment of cancer-associated thrombosis...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29435788/the-psychosocial-treadmill-the-road-to-improving-high-risk-behavior-in-advanced-therapy-candidates
#15
REVIEW
Laura Newman
PURPOSE OF REVIEW: The purpose of this review is to explore the evaluation and identification of psychosocial risk factors during the heart transplant evaluation process with the goal of improving psychosocial candidacy prior to transplant listing. Subsequently, more patients will be able to receive life-saving heart transplant and experience success after transplant. RECENT FINDINGS: Evaluating and identifying psychosocial risk factors is an essential component of the transplant evaluation process...
April 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29410725/a-retrospective-review-of-new-onset-dermatitis-in-patients-aged-60-years-or-older
#16
REVIEW
Rebecca F Wang, Benjamin H Kaffenberger, Jessica A Kaffenberger
Background: New-onset dermatitis in the elderly can be attributed to a variety of disease processes. We defined new-onset dermatitis in which the etiology is attributed solely to age-related processes as "dermatitis of immune senescence"-a diagnosis of exclusion based on clinical presentation and further diagnostic testing. Objective: Retrospective cohort of elderly patients with new-onset dermatitis to examine the differences in demographics, work-up, and treatments between patients with dermatitis of immune senescence and those patients ultimately given more specific diagnoses...
January 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29389745/safety-and-efficacy-of-rituximab-experience-of-a-single-multiple-sclerosis-center
#17
Brett Alldredge, Allison Jordan, Jaime Imitola, Michael K Racke
OBJECTIVES: Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system. B cells play an important pathogenic role in MS. Rituximab (RTX), a B-cell depleting drug, has been used to treat MS and neuromyelitis optica (NMO). Patient characteristics, safety, and efficacy measures are reviewed to ascertain the therapeutic benefit and safety of RTX in a real-world setting with long-term follow-up. METHODS: This is a retrospective chart review of patients who received RTX at The Ohio State University's MS clinic from January 2005 to October 2016...
March 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29337427/outcomes-from-the-first-helene-fuld-health-trust-national-institute-for-evidence-based-practice-in-nursing-and-healthcare-invitational-expert-forum
#18
Bernadette Mazurek Melnyk, Lynn Gallagher-Ford, Cindy Zellefrow, Sharon Tucker, Laurel Van Dromme, Bindu Koshy Thomas
BACKGROUND: Even though multiple positive outcomes are the result of evidence-based care, including improvements in healthcare quality, safety, and costs, it is not consistently delivered by clinicians in healthcare systems throughout the world. AIMS: In an attempt to accelerate the implementation of evidence-based practice (EBP) across the United States, an invitational Interprofessional National EBP Forum to determine major priorities for the advancement of EBP was held during the launch of the newly established Helene Fuld Health Trust National Institute for Evidence-Based Practice in Nursing and Healthcare at The Ohio State University College of Nursing...
February 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29323288/impacts-of-simulated-erosion-and-soil-amendments-on-greenhouse-gas-fluxes-and-maize-yield-in-miamian-soil-of-central-ohio
#19
Yanru Liang, Rattan Lal, Shengli Guo, Ruiqiang Liu, Yaxian Hu
Erosion-induced topsoil loss is a threat to sustainable productivity. Topsoil removal from, or added to, the existing surface is an efficient technique to simulate on-site soil erosion and deposition. A 15-year simulated erosion was conducted at Waterman Farm of Ohio State University to assess impacts of topsoil depth on greenhouse gas (GHG) emissions and maize yield. Three topsoil treatments were investigated: 20 cm topsoil removal, 20 cm topsoil addition, and undisturbed control. Results show that the average global warming potential (GWP) (Mg CO2 Eq ha-1 growing season-1 ) from the topsoil removal plot (18...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29284362/a-retrospective-review-of-fall-risk-factors-in-the-bone-marrow-transplant-inpatient-service
#20
Cory M Vela, Lisa M Grate, Ali McBride, Steven Devine, Leslie A Andritsos
Purpose The purpose of this study was to compare medications and potential risk factors between patients who experienced a fall during hospitalization compared to those who did not fall while admitted to the Blood and Marrow Transplant inpatient setting at The James Cancer Hospital. Secondary objectives included evaluation of transplant-related disease states and medications in the post-transplant setting that may lead to an increased risk of falls, post-fall variables, and number of tests ordered after a fall...
January 1, 2017: Journal of Oncology Pharmacy Practice
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