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Calcium oxalate stone

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https://www.readbyqxmd.com/read/29333512/fourier-transform-infrared-spectroscopy-for-analysis-of-kidney-stones
#1
Aysha Habib Khan, Sheharbano Imran, Jamsheer Talati, Lena Jafri
Purpose: To compare the results of a chemical method of kidney stone analysis with the results of Fourier transform infrared (FT-IR) spectroscopy. Materials and Methods: Kidney stones collected between June and October 2015 were simultaneously analyzed by chemical and FT-IR methods. Results: Kidney stones (n=449) were collected from patients from 1 to 81 years old. Most stones were from adults, with only 11.5% from children (aged 3-16 years) and 1...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29330993/chemical-composition-of-stones-in-paediatric-urolithiasis
#2
Kiran Imran, Mirza Naqi Zafar, Naureen Fatima, Uzma Ozair, Sajid Sultan, Syed Adibul Hasan Rizvi
BACKGROUND: Chemical composition of stones is one of the important diagnostic criteria for aetiology of stone formation and treatment to prevent recurrence. This paper reports composition of stones in children at a tertiary hospital by Fourier Transformation Infrared Spectroscopy (FTIR). METHODS: Between January-June 2015, 412 urinary stones from children were analysed by FTIR. Chi-square tests were used for the comparison of categorical measurements between groups...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29319486/evaluating-factors-that-dictate-struvite-stone-composition-a-multi-institutional-clinical-experience-from-the-edge-research-consortium
#3
Ryan Kendrick Flannigan, Andrew Battison, Shubha De, Mitchell R Humphreys, Markus Bader, Ekaterina Lellig, Manoj Monga, Ben H Chew, Dirk Lange
INTRODUCTION: Struvite stones account for 15% of urinary calculi and are typically associated with urease-producing urinary tract infections and carry significant morbidity. This study aims to characterize struvite stones based on purity of stone composition, bacterial speciation, risk factors, and clinical features. METHODS: Retrospective data was collected from patients diagnosed with infection stones between 2008 and 2012. Stone analysis, perioperative urine cultures, bacterial speciation, and clinical data were collected and analyzed...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29277881/quantitative-mineralogical-composition-of-calculi-and-urine-abnormalities-for-calcium-oxalate-stone-formers-a-single-center-results
#4
Andrey V Kustov, Alexander I Strelnikov
PURPOSE: The paper focuses on the relationship of risk factors and metabolic disorders with mineralogical composition of calculi, age and gender of calcium oxalate stone formers. MATERIALS AND METHODS: Stone mineralogical composition, 24 hour biochemistry and pH-profile of urine were examined for sixty four stone formers using powder X-ray diffraction, spectrophotometric and potentiometric techniques. RESULTS: The analysis indicated that 44 % of calculi were composed of pure calcium oxalate monohydrate, whereas other 56 % contained both monohydrate and dihydrate or usually their mixtures with hydroxyl apatite...
December 26, 2017: Urology Journal
https://www.readbyqxmd.com/read/29249235/kidney-stone-composition-in-the-kingdom-of-saudi-arabia%C3%A2
#5
Abdulrazack Amir, Brian R Matlaga, Justin B Ziemba, Salwa Sheikh
INTRODUCTION: Urolithiasis is a globally-distributed disease; however, its prevalence varies across countries and regions. Countries in the Middle East have been reported to have particularly high nephrolithiasis prevalence rates. To date, however, we have an incomplete understanding of the composition of stones seen in this region. Therefore, we performed a study to characterize stone composition over a 14-year period in the Eastern Province of the Kingdom of Saudi Arabia (KSA). MATERIALS AND METHODS: A retrospective review of all adult patients who had the composition of their upper urinary tract calculi analyzed at Johns Hopkins Aramco Healthcare (JHAH) between 1999 and 2013 was performed...
December 18, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29236240/effects-of-small-molecules-water-that-may-retard-kidney-stone-formation
#6
Yang Li, Jichuan Pan, Yue Zhang, Yangtao Chang, Xiaoxiong Yang, Baoyu Yang, Xu Mao, Zhonghui Wang, Bing Gao, Xiuli Lu
PURPOSE: Water intake is important for preventing kidney stones. Small molecules water is a more active restructured water under magnetic field. Here, we studied the relation between small molecules water and crystal formation in the rat kidney. MATERIALS: The small molecules water was prepared by a water machine providing a 0.8-T magnetic field. Calcium oxalate crystals were induced by 0.75% EG (ethylene glycol) in male Sprague-Dawley rats by drinking small molecules water and plain water for up to 6 weeks, respectively...
December 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29234857/high-frequency-and-wide-range-of-human-kidney-papillary-crystalline-plugs
#7
Léa Huguet, Marine Le Dudal, Marine Livrozet, Dominique Bazin, Vincent Frochot, Joëlle Perez, Jean-Philippe Haymann, Isabelle Brocheriou, Michel Daudon, Emmanuel Letavernier
Most of kidney stones are supposed to originate from Randall's plaque at the tip of the papilla or from papillary tubular plugs. Nevertheless, the frequency and the composition of crystalline plugs remain only partly described. The objective was to assess the frequency, the composition and the topography of papillary plugs in human kidneys. A total of 76 papillae from 25 kidneys removed for cancer and without stones were analysed by immunohistochemistry combined with Yasue staining, field emission-scanning electron microscopy and Fourier transformed infrared micro-spectroscopy...
December 12, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29211748/interactions-between-abundant-fungal-species-influence-the-fungal-community-assemblage-on-limestone
#8
Alejandro Morón-Ríos, Sergio Gómez-Cornelio, Benjamin Otto Ortega-Morales, Susana De la Rosa-García, Laila Pamela Partida-Martínez, Patricia Quintana, José Armando Alayón-Gamboa, Silvia Cappello-García, Santiago González-Gómez
The assembly of fungal communities on stone materials is mainly influenced by the differential bioreceptivity of such materials and environmental conditions. However, little is known about the role of fungal interactions in the colonization and establishment of fungal species. We analyzed the effects of intra- and interspecific interactions between 11 species of fungi in oligotrophic and copiotrophic media and on limestone coupons. In a previous study, these species were the most frequently isolated in the epilithic biofilms of limestone walls exposed to a subtropical climate...
2017: PloS One
https://www.readbyqxmd.com/read/29202723/changes-in-urinary-risk-profile-after-short-term-low-sodium-and-low-calcium-diet-in-recurrent-swiss-kidney-stone-formers
#9
Harald Seeger, Andrea Kaelin, Pietro M Ferraro, Damian Weber, Philippe Jaeger, Patrice Ambuehl, William G Robertson, Robert Unwin, Carsten A Wagner, Nilufar Mohebbi
BACKGROUND: Kidney stone disease is common in industrialized countries. Recently, it has attracted growing attention, because of its significant association with adverse renal outcomes, including end stage renal disease. Calcium-containing kidney stones are frequent with high recurrence rates. While hypercalciuria is a well-known risk factor, restricted intake of animal protein and sodium, combined with normal dietary calcium, has been shown to be more effective in stone prevention compared with a low-calcium diet...
December 4, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29198849/oxalate-degrading-enzyme-recombined-lactic-acid-bacteria-strains-reduce-hyperoxaluria
#10
Chenming Zhao, Huan Yang, Xiaojing Zhu, Yang Li, Ning Wang, Shanfu Han, Hua Xu, Zhiqiang Chen, Zhangqun Ye
OBJECTIVE: To develop recombinant lactic acid bacteria (LAB) strains that express oxalate-degrading enzymes through biotechnology-based approach for the treatment of hyperoxaluria by oral administration. MATERIAL AND METHODS: The coding gene of oxalate decarboxylase (ODC) and oxalate oxidase (OxO) was transformed into Lactococcus lactis MG1363. The oxalate degradation ability in vitro was evaluated in media with high concentration of oxalate. Hyperoxaluria rat models through high oxalate diet were given recombinant LAB through oral administration...
November 30, 2017: Urology
https://www.readbyqxmd.com/read/29197934/effects-of-statin-treatment-with-atorvastatin-on-urolithiasis-associated-urinary-metabolic-risk-factors-an-experimental-study
#11
Mustafa Zafer Temiz, Emrah Yuruk, Kasim Ertas, Oguzhan Zengi, Atilla Semercioz
PURPOSE: To investigate whether atorvastatin has favorable effects on urinary metabolic risk factors associated with urolithiasis. METHODS: Sixteen male Sprague-Dawley rats were randomly divided into two groups, and baseline spot and 24-h urine samples were collected. Distilled water and atorvastatin were administered to rats during 4 weeks in the control and atorvastatin groups, respectively. At the end of the experimental procedure, spot and 24-h urine samples were collected again...
December 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29190944/alteration-of-exosomes-secreted-from-renal-tubular-epithelial-cells-exposed-to-high-concentration-oxalate
#12
Ziqi He, Xiaofeng Guan, Yunlong Liu, Zhiwei Tao, Quan Liu, Jihua Wu, Yaoliang Deng
Oxalate (Ox) is a metabolic end product that is produced by the kidneys and is associated with several pathological conditions. The accumulation of oxalate in the body is one of the factors that lead to calcium oxalate kidney stones. To simulate the high-concentration Ox environment in vivo, we established an in vitro model of high Ox using renal tubular epithelial (HK-2) cells. Cell viability and proliferation were assessed to evaluate the effects of various concentrations (0, 0.25, 0.5, 1, 2, 4, 5, 8 and 10Mm) of Ox on HK-2 cells to select the optimum concentration and time to extract the exosomes...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29162379/-epidemiology-of-urolithiasis-in-french-west-indies-a-retrospective-study
#13
K Kaulanjan, A Cerruti, V Galantine, C Laine, J Rose Dite Modestine, G Gourtaud, C Senechal, V Roux, R Eyraud, P Blanchet, L Brureau
INTRODUCTION: The incidence of urolithiasis is increasing with dietary changes especially in developed countries. Guadeloupe is a French department overseas where western diet meets traditional local food. The objective was to describe and analyze the epidemiology of urolithiasis in Guadeloupe. MATERIAL AND METHODS: We conducted a retrospective single-center study throughout the year 2015 on patients hospitalized for urolithiasis at University Hospital of Pointe-à-Pitre...
November 18, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29161895/editorial-comment-on-end-2017-0436-or-r1
#14
Michael Grasso
A central component of percutaneous nephrostolithotomy is an endoscopic lithotrite that safely and efficiently clears stone of all compositions from the intrarenal collecting system. The current multicenter trial studied 3 lithotrite combinations employing both mechanical ballistic and ultrasonic energy to fragment and evacuate with suction stone debris. What is clear from this work is that, with regard to the timely clearance of the stone burden and peri-operative complications, there is minimal difference between the devices studied, nothing special and nothing new...
November 22, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29160413/long-non-coding-rna-chchd4p4-promotes-epithelial-mesenchymal-transition-and-inhibits-cell-proliferation-in-calcium-oxalate-induced-kidney-damage
#15
C Zhang, J Yuan, H Hu, W Chen, M Liu, J Zhang, S Sun, Z Guo
Kidney stone disease is a major cause of chronic renal insufficiency. The role of long non-coding RNAs (lncRNAs) in calcium oxalate-induced kidney damage is unclear. Therefore, we aimed to explore the roles of lncRNAs in glyoxylate-exposed and healthy mouse kidneys using microarray technology and bioinformatics analyses. A total 376 mouse lncRNAs were differentially expressed between the two groups. Using BLAST, 15 lncRNA homologs, including AU015836 and CHCHD4P4, were identified in mice and humans. The AU015836 expression in mice exposed to glyoxylate and the CHCHD4P4 expression in human proximal tubular epithelial (HK-2) cells exposed to calcium oxalate monohydrate were analyzed, and both lncRNAs were found to be upregulated in response to calcium oxalate...
November 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29142413/antiurolithiatic-potential-of-neeri-against-calcium-oxalate-stones-by-crystallization-inhibition-free-radicals-scavenging-and-nrk-52e-cell-protection-from-oxalate-injury
#16
Parveen Kumar Goyal, Santosh Kumar Verma, Anil Kumar Sharma
Background: Neeri is a well-established polyherbal formulation prescribed for renal stones by the physicians but has not been experimentally evaluated for its antiurolithiatic potential using cell-lines. Objective: This study is aimed to scientifically substantiate the antiurolithiatic effect of Neeri extract (NRE) through calcium oxalate (CaOx) crystallization inhibition, scavenging of free radicals, and protection of renal tubular epithelial NRK-52E cells from oxalate-induced injury...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29132983/relative-supersaturation-of-24-hour-urine-and-likelihood-of-kidney-stones
#17
Megan Prochaska, Eric Taylor, Pietro Manuel Ferraro, Gary Curhan
PURPOSE: Relative supersaturations of calcium oxalate, calcium phosphate, and uric acid are used clinically in kidney stone prevention. The magnitudes of association between relative supersaturation and stone risk require further quantification. MATERIALS AND METHODS: We performed a cross-sectional study using 24-hour urine collections from Nurses' Health Study I (NHS I), Nurses' Health Study II (NHS II), and Health Professional Follow-up Study (HPFS) cohorts to quantify the association between calcium oxalate, calcium phosphate, and uric acid relative supersaturations levels and likelihood of stone formation...
November 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29110180/correlation-between-the-molecular-effects-of-mutations-at-the-dimer-interface-of-alanine-glyoxylate-aminotransferase-leading-to-primary-hyperoxaluria-type-i-and-the-cellular-response-to-vitamin-b6
#18
Mirco Dindo, Elisa Oppici, Daniele Dell'Orco, Rosa Montone, Barbara Cellini
Primary hyperoxaluria type I (PH1) is a rare disease caused by the deficit of liver alanine-glyoxylate aminotransferase (AGT). AGT prevents oxalate formation by converting peroxisomal glyoxylate to glycine. When the enzyme is deficient, progressive calcium oxalate stones deposit first in the urinary tract and then at the systemic level. Pyridoxal 5'-phosphate (PLP), the AGT coenzyme, exerts a chaperone role by promoting dimerization, as demonstrated by studies at protein and cellular level. Thus, variants showing a destabilized dimeric structure should, in principle, be responsive to vitamin B6, a precursor of PLP...
November 6, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29101428/composition-of-urinary-calculi-in-infants-a-report-from-an-endemic-country
#19
Mirza Naqi Zafar, Salma Ayub, Hafsa Tanwri, Syed Ali Anwar Naqvi, Syed Adibul Hasan Rizvi
Pediatric urolithiasis remains endemic in low-resource countries where infants constitute 17-40% of all children with urolithiasis. This study reports socio-economic factors, medical history and chemical composition of urinary stones in 976 infants of up to 2 years of age. Between 1992 and 2016, 976 infants presented to our institute with 1038 stones. Chemical composition of stones was analyzed by Fourier transformation infrared spectroscopy (FTIR). The mean age of infants was 19.5 ± 5.74 months with a M:F ratio of 5...
November 3, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29095693/reference-intervals-for-stone-risk-factors-in-24-h-urine-among-healthy-adults-of-the-han-population-in-china
#20
Zanlin Mai, Xiaoxia Li, Zelin Cui, Wenqi Wu, Yongda Liu, Lili Ou, Yueping Liang, Zhijian Zhao, Yang Liu, Xing Mai, Wei Zhu, Tao Zhang, Chao Cai, Houmeng Yang, Guohua Zeng
BACKGROUND: The aim of the study was to establish reference intervals for 24-h urinary stone risk factors in the healthy Chinese Han population. METHODS: From May 2013 to July 2014, we collected and analyzed 24-h urine samples from healthy adult Han population during a cross-sectional study across China. The protocol for analysis of 24-h urine included volume, pH, oxalate, citrate, sodium, potassium, chloride, calcium, phosphorous, creatinine, urate, magnesium, the ion activity products of calcium oxalate (AP(CaOx) indexs) and calcium phosphate (AP(CaP) indexs)...
November 2, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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