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Renal stone

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https://www.readbyqxmd.com/read/27921023/effects-of-hydrophilic-extract-of-nasturtium-officinale-on-prevention-of-ethylene-glycol-induced-renal-stone-in-male-wistar-rats
#1
Sadrollah Mehrabi, Eslam Askarpour, Farhad Mehrabi, Ramin Jannesar
BACKGROUND: Nasturtium officinale is a traditional herb that is used for diuresis. OBJECTIVES: The aim of this study is to determine the effects of hydrophilic extract of Nasturtium officinale on ethylene glycol-induced renal stone in male Wistar rats. MATERIALS AND METHODS: In this study 32 male Wistar rats were randomly divided in six groups and studied during 30 days. Two groups of negative and healthy control received 1% ethylene glycol in water respectively...
October 2016: Journal of Nephropathology
https://www.readbyqxmd.com/read/27920983/bacteremic-renal-stone-associated-urinary-tract-infection-caused-by-nontypable-haemophilus-influenzae-a-rare-invasive-disease-in-an-immunocompetent-patient
#2
Masanao Fujii, Harumi Gomi, Haruhiko Ishioka, Noriko Takamura
Haemophilus species are known to colonize the upper respiratory tract and can cause infections. However Haemophilus influenzae has been rarely described as a cause of genitourinary tract infection. We report a 44-year-old nonimmunocompromised Japanese man with bacteremic pyelonephritis caused by a nontypable H. influenzae associated with a left ureteral calculus. The organism was isolated from both blood and urine cultures. Treatment consisted of 14 days of intravenous ceftriaxone and oral amoxicillin one after than other and insertion of a left ureteral stent...
2017: IDCases
https://www.readbyqxmd.com/read/27919136/-renal-failure-due-to-a-bladder-stone-associated-with-a-suprapubic-catheter-left-for-ten-years-a-case-report
#3
Akira Kazama, Shugo Hanyu
A 43-year-old male was injured by a heavy industrial machine in 1998, and suprapubic catheter was inserted because of pubic fracture and urethral injury. He monthly changed the catheter until 2005, but he stopped going to the hospital. Ten years later, in August 2015, he visited our hospital for tiredness. Computed tomography scan showed a huge bladder stone (6×6×4 cm) with suprapubic catheter and bilateral severe hydronephrosis. The level of serum creatinine was 4.79 mg/dl. Bilateral nephrostomy was performed immediately...
November 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27917808/unenhanced-computed-tomography-findings-of-renal-papillae-in-patients-with-a-ureteral-stone
#4
Selim Serter, Erkan Sahin, Utku Mahir Yildirim, Murat Arslan, Ayhan Karakose
PURPOSE: In some patients with a ureteral stone without uretero-hydronephrosis, it is difficult to determine the location of the stone. The objective of the present study was to investigate the changes in renal papillae using unenhanced computerized tomography (uCT) and determine the side of calculi using the renal papillary findings in patients with a ureteral stone. METHODS: uCT data from 81 patients were retrospectively reviewed for this study. The inclusion criteria were unilateral ureteral calculi, no renal calculi and no hydronephrosis...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27917317/flexible-ureteroscopy-for-renal-stone-without-preoperative-ureteral-stenting-shows-good-prognosis
#5
Jiaqiao Zhang, Chuou Xu, Deng He, Yuchao Lu, Henglong Hu, Baolong Qin, Yufeng Wang, Qing Wang, Cong Li, Shaogang Wang, Jihong Liu
PURPOSE: To clarify the outcome of flexible ureteroscopy (fURS) for management of renal calculi without preoperative stenting. METHODS: A total of 171 patients who received 176 fURS procedures for unilateral renal stones were reviewed. All procedures were divided into two groups depending on whether they received ureteral stenting preoperatively. Baseline characteristics of patients, stone burden, operation time, stone-free rates, and complications were compared between both groups...
2016: PeerJ
https://www.readbyqxmd.com/read/27915449/common-variants-in-cldn14-are-associated-with-differential-excretion-of-magnesium-over-calcium-in-urine
#6
REVIEW
Tanguy Corre, Eric Olinger, Sarah E Harris, Michela Traglia, Sheila Ulivi, Stefania Lenarduzzi, Hendrica Belge, Sonia Youhanna, Natsuko Tokonami, Olivier Bonny, Pascal Houillier, Ozren Polasek, Ian J Deary, John M Starr, Daniela Toniolo, Paolo Gasparini, Peter Vollenweider, Caroline Hayward, Murielle Bochud, Olivier Devuyst
The nature and importance of genetic factors regulating the differential handling of Ca(2+) and Mg(2+) by the renal tubule in the general population are poorly defined. We conducted a genome-wide meta-analysis of urinary magnesium-to-calcium ratio to identify associated common genetic variants. We included 9320 adults of European descent from four genetic isolates and three urban cohorts. Urinary magnesium and calcium concentrations were measured centrally in spot urine, and each study conducted linear regression analysis of urinary magnesium-to-calcium ratio on ~2...
December 3, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27915394/timelines-of-the-free-particle-and-fixed-particle-models-of-stone-formation-theoretical-and-experimental-investigations
#7
REVIEW
D J Kok, W Boellaard, Y Ridwan, V A Levchenko
Two major theories on renal stone formation will be reviewed, the "free-particle" and "fixed-particle" mechanisms. These theories combine data on intrinsic factors (inborn metabolic errors), extrinsic factors (diet), renal cell responses and the physico-chemistry and biochemistry of urine into mechanisms of stone formation. This paper describes the specific role of time in both mechanisms. The timeline of crystal- and stone formation was deducted from literature data and was measured for two stones using radioisotope decay analysis...
December 3, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27914711/proteomic-based-research-strategy-identified-laminin-subunit-alpha-2-as-a-potential-urinary-specific-biomarker-for-the-medullary-sponge-kidney-disease
#8
Antonia Fabris, Maurizio Bruschi, Laura Santucci, Giovanni Candiano, Simona Granata, Alessandra Dalla Gassa, Nadia Antonucci, Andrea Petretto, Gian Marco Ghiggeri, Giovanni Gambaro, Antonio Lupo, Gianluigi Zaza
Medullary sponge kidney (MSK) disease, a rare kidney malformation featuring recurrent renal stones and nephrocalcinosis, continues to be diagnosed using expensive and time-consuming clinical/instrumental tests (mainly urography). Currently, no molecular diagnostic biomarkers are available. To identify such we employed a proteomic-based research strategy utilizing urine from 22 patients with MSK and 22 patients affected by idiopathic calcium nephrolithiasis (ICN) as controls. Notably, two patients with ICN presented cysts...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27913853/the-role-of-intestinal-oxalate-transport-in-hyperoxaluria-and-the-formation-of-kidney-stones-in-animals-and-man
#9
REVIEW
Jonathan M Whittamore, Marguerite Hatch
The intestine exerts a considerable influence over urinary oxalate in two ways, through the absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for elimination of this waste metabolite. Knowledge of the mechanisms responsible for oxalate absorption and secretion by the intestine therefore have significant implications for understanding the etiology of hyperoxaluria, as well as offering potential targets for future treatment strategies for calcium oxalate kidney stone disease. In this review, we present the recent developments and advances in this area over the past 10 years, and put to the test some of the new ideas that have emerged during this time, using human and mouse models...
December 2, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27913238/contemporary-ureteroscopic-management-of-renal-stones
#10
S Proietti, T Knoll, G Giusti
The advancements in the endourological armamentarium and the evolution of ureteroscopes with the advent of fiberoptic first and then digital technology, the introduction of holmium laser lithotripters, together with the increasing number of requests for minimally invasive procedures has ameliorated outcomes, patients' safety and comfort, making the use of flexible ureteroscopy for urinary calculi increasingly attractive and widespread among urological community. Due to its high stone-free rates and low morbidity, flexible ureteroscopy has become a viable option for the treatment of renal stones...
November 29, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27909620/is-normal-saline-the-best-irrigation-fluid-to-be-used-during-percutaneous-nephrolithotomy-in-renal-failure-patient-a-prospective-randomized-controlled-trial
#11
Bimalesh Purkait, Manoj Kumar, Ankur Bansal, Ashok Kumar Sokhal, Satya Narayan Sankhwar, Kawaljit Singh
OBJECTIVE: Endoscopic procedures like percutaneous nephrolithotomy (PCNL) needs continuous irrigation for better vision and to wash away stone fragments and blood clots. Systemic absorption of irrigation fluids may lead to fluid overload and electrolyte disequilibrium. Renal failure patients are more prone to these electrolyte disturbances. We have evaluated the outcomes of normal saline as irrigation solution to be used in renal failure patient in comparison to distilled water. METHODS: Seventy-six patients with renal calculi were enrolled in this study between September, 2014, and December, 2015...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27909619/the-role-of-ultra-mini-percutaneous-nephrolithotomy-in-the-treatment-of-kidney-stones
#12
Abdulkadir Tepeler, İsmail Başıbüyük, Muhammed Tosun, Abdullah Armağan
OBJECTIVE: In our study we aimed to evaluate outcomes of ultra-mini-percutaneous nephrolithotomy (UMP) performed for the treatment of kidney stones. MATERIAL AND METHODS: Between October 2014 and September 2015, a single surgeon performed UMP on a total of 49 consecutive patients with symptomatic kidney stones at our center. Pregnants, anticogulant users, patients with bleeding diathesis pyonephrosis, and partial/complete staghorn stones were excluded from the study...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27904915/studies-using-a-porcine-model-what-insights-into-human-calcium-oxalate-stone-formation-mechanisms-has-this-model-facilitated
#13
REVIEW
Kristina L Penniston, Sutchin R Patel, Denise J Schwahn, Stephen Y Nakada
Animal models are useful in the study of many human diseases. Our current understanding of the biological, physiological, and biochemical aspects of hyperoxaluria and calcium oxalate urolithiasis has been greatly informed by studies using animals. Recently, limitations in the extrapolation to humans of research results derived from laboratory rodents have been identified. The use in biomedical research of a variety of organisms, including large animals, is increasingly encouraged. The purpose of this article is to review the use of pigs in biomedical and stone research, to provide a rationale for using pigs in metabolic stone research, and to describe our 8-year experience in developing a porcine platform for studying hyperoxaluria and calcium oxalate urolithiasis...
November 30, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27902848/topiramate-in-migraine-prevention-a-2016-perspective
#14
Stephen D Silberstein
BACKGROUND: In evidence-based guidelines published in 2000, topiramate was a third-tier migraine preventive with no scientific evidence of efficacy; recommendation for its use reflected consensus opinion and clinical experience. Its neurostabilizing activity, coupled with its favorable weight profile, made topiramate an attractive alternative to other migraine preventives that caused weight gain. When guidelines for migraine prevention in episodic migraine were published in 2012, topiramate was included as a first-line option based on double-blind, randomized controlled trials involving nearly 3000 patients...
November 30, 2016: Headache
https://www.readbyqxmd.com/read/27900939/incidence-and-implications-of-silent-hydronephrosis-following-percutaneous-nephrolithotomy%C3%A2
#15
Lawrence Dagrosa, Rachel Moses, Vernon Pais
OBJECTIVE: While routine renal imaging following ureteroscopy for urinary calculi has been recommended to screen for asymptomatic "silent" obstruction, the rate of silent obstruction following percutaneous nephrolithotomy (PCNL) remains poorly defined, and no consensus recommendations exist on routine postoperative imaging. At our institution, we sought to assess the incidence of silent hydronephrosis (SH), as a screen for obstruction, following PCNL. METHODS: The records of all 162 patients who met study inclusion criteria were reviewed...
November 30, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27900407/do-inhibitors-of-crystallisation-play-any-role-in-the-prevention-of-kidney-stones-a-critique
#16
REVIEW
William G Robertson
A critical examination of data in the literature and in as yet unpublished laboratory records on the possible role of so-called inhibitors of crystallisation in preventing the formation of calcium-containing kidney stones leads to the following conclusions. So-called inhibitors of spontaneous "self-nucleation" are unlikely to play any role in the initiation of the crystallisation of CaOx or CaP in urine because excessive urinary supersaturation of urine with respect to these salts dominates the onset of "self-nucleation" within the normal time frame of the transit of tubular fluid through the nephron (3-4 min)...
November 29, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27896392/tubular-and-genetic-disorders-associated-with-kidney-stones
#17
REVIEW
Nilufar Mohebbi, Pietro Manuel Ferraro, Giovanni Gambaro, Robert Unwin
This concise review summarizes our current understanding and the recent developments in genetics and related renal tubular disorders that have been linked with, or have been shown to be causal in, renal stone disease. The aim is to provide a readily accessible quick and easy update for urologists, nephrologists and endocrine or metabolic physicians whose practice involves the diagnosis and management of nephrolithiasis. An important message is to always consider a seemingly rare, and usually genetic, cause of kidney stones, since some of these are emerging as more common than originally thought, especially in adult clinical practice in which a family history of stones is a common finding...
November 28, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27896391/histological-aspects-of-the-fixed-particle-model-of-stone-formation-animal-studies
#18
REVIEW
Saeed R Khan
Crystallization by itself is not harmful as long as the crystals are not retained in the kidneys and are allowed to pass freely down the renal tubules to be excreted in the urine. A number of theories have been proposed, and studies performed, to determine the mechanisms involved in crystal retention within the kidneys. It has been suggested that urinary transit through the nephron is too fast for crystals to grow large enough to be retained. Thus, free particle mechanism alone cannot lead to stone formation, and there must be a mechanism for crystal fixation within the kidneys...
November 28, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27889982/external-validation-and-evaluation-of-reliability-and-validity-of-the-triple-d-score-to-predict-stone-free-status-after-shock-wave-lithotripsy
#19
Faruk Ozgor, Muhammed Tosun, Yunus Kayali, Metin Savun, Murat Binbay, Abdulkadir Tepeler
OBJECTIVE: The Triple D scoring system is defined as novel and simple nomogram using the main parameters (skin-to-stone distance, stone density, and volume) in order to indicate most appropriate patients for shock-wave lithotripsy (SWL). We aimed to evaluate the accuracy of the Triple D scoring system in predicting SWL success rates. PATIENTS AND METHODS: In two tertiary academic centers, charts were retrospectively analyzed of patients who had, between January 2014 and May 2016, been treated by SWL for radiopaque kidney stones...
November 27, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27888303/dual-energy-ct-workflow-multi-institutional-consensus-on-standardization-of-abdominopelvic-mdct-protocols
#20
Bhavik N Patel, Lauren Alexander, Brian Allen, Lincoln Berland, Amir Borhani, Achille Mileto, Courtney Moreno, Desiree Morgan, Dushyant Sahani, William Shuman, Eric Tamm, Mitchell Tublin, Benjamin Yeh, Daniele Marin
PURPOSE: To standardize workflow for dual-energy computed tomography (DECT) involving common abdominopelvic exam protocols. MATERIALS AND METHODS: 9 institutions (4 rsDECT, 1 dsDECT, 4 both) with 32 participants [average # years (range) in practice and DECT experience, 12.3 (1-35) and 4.6 (1-14), respectively] filled out a single survey (n = 9). A five-point agreement scale (0, 1, 2, 3, 4-contra-, not, mildly, moderately, strongly indicated, respectively) and utilization scale (0-not performing and shouldn't; 1-performing but not clinically useful; 2-performing but not sure if clinically useful; 3-not performing it but would like to; 4-performing and clinically useful) were used...
November 25, 2016: Abdominal Radiology
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