Read by QxMD icon Read

Actinic prurigo

Alexandra Mancheno-Valencia, Ronell Eduardo Bologna-Molina, Sonia Toussaint-Caire, María Elisa Vega-Memije, Juan Carlos Cuevas-González
Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained lymphoid follicles (Ki 67: epidermis [17...
April 2018: Indian Journal of Pathology & Microbiology
Juan Carlos Cuevas-Gonzalez, María Elisa Vega-Memíje, Socorro Aída Borges-Yáñez, Erika Rodríguez-Lobato
BACKGROUND: Actinic prurigo (AP) is an idiopathic photodermatosis. Although its initial manifestations can appear in 6 to 8-year-old children, cases are diagnosed later, between the second and fourth decades of life, when the injuries are exacerbated. OBJECTIVE: To identify risk factors associated with clinical manifestations of AP such as skin and mucosal lesions. METHODS: Thirty patients with AP and 60 controls were included in the study, the dependent variable was the presence of skin or labial mucosal lesions, the independent variables were age, sex, solar exposure, living with pets or farm animals, exposure to wood smoke, smoking habit, years smoking, and hours spent per day and per week in contact with people who smoke...
November 2017: Anais Brasileiros de Dermatologia
Jan C Sitek
Actinic prurigo is a pruritic sun-induced dermatosis classified among the immunologically mediated photodermatoses. The disease is a well-known entity among Native Americans and in Central and South America, however rare in Caucasians with only a few reports from Australia, Britain and France. We report the first case of actinic prurigo in a Scandinavian patient, responding favorably to systemic treatment with cyclosporine A.
March 13, 2017: Dermatology Reports
Amy Kalowitz Bieber, David E Cohen, Jennifer A Stein
No abstract text is available yet for this article.
May 2016: JAAD Case Reports
Juan Carlos Cuevas-Gonzalez, Zahide Lievanos-Estrada, Maria Elisa Vega-Memije, Maria Teresa Hojyo-Tomoka, Luciano Dominguez-Soto
BACKGROUND: Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4. OBJECTIVES: To examine the association of serum IgE levels and the clinical severity of injuries. METHODS: This case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subjects, from whom 3cc of peripheral blood was taken for immunoassay...
January 2016: Anais Brasileiros de Dermatologia
Jose A Plaza, Sonia Toussaint, Victor G Prieto, Patricia Mercadillo, Juan C Diez de Medina, Silvia Lourenco, Bjorn Batdorf, Martin Sangueza
Actinic prurigo (AP) is a chronic idiopathic photodermatosis that primarily affects American Indians in the United States and Mestizos in Latin American countries. Clinically, the onset of the disease is usually in the first decade of life but may appear initially in adult life, and it is characterized by symmetric involvement of sun-exposed areas of the skin, particularly areas of the face, resulting in polymorphic erythematous papules, macules, and plaques in different stages of evolution. Lower lip involvement includes swelling, scaling, fissures, hyperpigmentation, and ulcerations of the vermilion border...
June 2016: American Journal of Dermatopathology
Alma Angélica Rodríguez-Carreón, Erika Rodríguez-Lobato, Georgina Rodríguez-Gutiérrez, Juan Carlos Cuevas-González, Alexandra Mancheno-Valencia, Martha Patricia Solís-Arias, María Elisa Vega-Memije, María Teresa Hojyo-Tomoka, Luciano Domínguez-Soto
Actinic prurigo is an idiopathic photodermatosis that affects the skin, as well as the labial and conjunctival mucosa in indigenous and mestizo populations of Latin America. It starts predominantly in childhood, has a chronic course, and is exacerbated with solar exposure. Little is known of its pathophysiology, including the known mechanisms of the participation of HLA-DR4 and an abnormal immunologic response with increase of T CD4+ lymphocytes. The presence of IgE, eosinophils, and mast cells suggests that it is a hypersensitivity reaction (likely type IVa or b)...
July 2015: Skinmed
Qiping Chen, Meixin Shen, Yee Kiat Heng, Thiam Seng Colin Theng, Hong Liang Tey, Ee Chee Ren, Wei-Sheng Chong
Studies have reported the association of human leukocyte antigen (HLA) genes with susceptibility to develop actinic prurigo (AP) in Caucasians, but there were no studies in Asian populations, including the Chinese. Our study was performed to determine if AP is associated with susceptibility or protective HLA alleles or haplotypes in Singaporean Chinese. All Chinese patients diagnosed with AP at National Skin Center, Singapore, from January 2002 to April 2015 were invited to participate in the study. Clinical data and phototesting results were collated, and HLA typing was performed...
March 2016: Photochemistry and Photobiology
Eduwiges Martínez-Luna, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Juan-Carlos Cuevas-González, Erika Rodríguez-Lobato, María-Abril Martínez-Velasco, María-Elisa Vega-Memíje
BACKGROUND: Actinic prurigo (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a hypersensitivity reaction to the presence of eosinophils and the local production of IgE. MATERIAL AND METHODS: Descriptive study, using paraffin blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Manuel Gea González. In 66 blocks from 63 patients, eosinophils were identified by hematoxylin and eosin staining, and mastocytes were labeled by immunohistochemistry...
December 2015: Journal of Clinical and Experimental Dentistry
Juan-Carlos Cuevas-González, María-Elisa Vega-Memíje, Francisco-Javier García-Vázquez, Erika Rodríguez-Lobato, José-Eduardo Farfán-Morales
BACKGROUND: Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway). MATERIAL AND METHODS: Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC)...
January 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
Divya Sharma, Shawn G Kwatra
Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ineffective, thalidomide, an immunomodulator and neuromodulator, may be a useful alternative treatment. Considerable relief of chronic pruritus has been demonstrated with thalidomide in case reports, case series, and controlled trials...
February 2016: Journal of the American Academy of Dermatology
Anne Cale Jones, H Stan McGuff, Michaell Huber
No abstract text is available yet for this article.
March 2015: Texas Dental Journal
Catherine S Yang, Changhyun Kim, Richard J Antaya
Thalidomide is resurging in the management of adult rheumatologic skin conditions, especially lupus erythematosus. Although use in pediatric patients is reported since the 1990s, there are no systematic reviews describing treatment in children. Thalidomide has immunomodulatory and anti-tumor necrosis factor-α effects as well as antiangiogenic properties, making it useful for a broad spectrum of inflammatory disorders. Thalidomide is second-line treatment for aphthous stomatitis and chronic graft-versus-host disease in children and has been prescribed for many other conditions including actinic prurigo and epidermolysis bullosa pruriginosa...
April 2015: Journal of the American Academy of Dermatology
Irina Ushach, Amanda M Burkhardt, Cynthia Martinez, Peter A Hevezi, Peter Arne Gerber, Bettina Alexandra Buhren, Holger Schrumpf, Ricardo Valle-Rios, Monica I Vazquez, Bernhard Homey, Albert Zlotnik
Cytokines are involved in many functions of the immune system including initiating, amplifying and resolving immune responses. Through bioinformatics analyses of a comprehensive database of gene expression (BIGE: Body Index of Gene Expression) we observed that a small secreted protein encoded by a poorly characterized gene called meteorin-like (METRNL), is highly expressed in mucosal tissues, skin and activated macrophages. Further studies indicate that Metrnl is produced by Alternatively Activated Macrophages (AAM) and M-CSF cultured bone marrow macrophages (M2-like macrophages)...
February 2015: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Juan Carlos Cuevas González, Francisco Javier García Vázquez, Erika Rodríguez Lobato, José Eduardo Farfán Morales, María Elisa Vega Memíje
No abstract text is available yet for this article.
March 2015: Photodermatology, Photoimmunology & Photomedicine
Ana Mo Miranda, Thiago M Ferrari, Juliana T Werneck, Arley Silva Junior, Karin S Cunha, Eliane P Dias
Actinic prurigo is a photodermatosis that can affect the skin, conjunctiva and lips. It is caused by an abnormal reaction to sunlight and is more common in high-altitude living people, mainly in indigenous descendants. The diagnosis of actinic prurigo can be challenging, mainly when lip lesions are the only manifestation, which is not a common clinical presentation. The aim of this article is to report two cases of actinic prurigo showing only lip lesions. The patients were Afro-American and were unaware of possible Indian ancestry...
August 16, 2014: World Journal of Clinical Cases
Martha C Valbuena, Sandra Muvdi, Henry W Lim
Actinic prurigo is a chronic photodermatosis with onset in childhood or before 20 years of age. It is most prevalent in Amerindians and Latin American mestizos, although it has been reported worldwide. Patients present with photodistributed, erythematous excoriated papules, cheilitis, and conjunctivitis. There is strong association with human leukocyte antigen DR4, especially the DRB1*0407 subtype. Treatment consists of photoprotection and the use of thalidomide.
July 2014: Dermatologic Clinics
Heidi Wat, Marlene Dytoc
BACKGROUND: Topical vitamin D is approved by the US Food and Drug Administration for the treatment of psoriasis but is also used off-label in the treatment of a variety of cutaneous diseases despite a lack of evidence-based guidelines. OBJECTIVE: The objective of this study was to provide evidence-based clinical guidelines for the off-label use of topical vitamin D in the treatment of dermatologic disease. METHODS: A systematic literature review was conducted via the MEDLINE, Embase, and CENTRAL databases for off-label uses of topical vitamin D analogues in the treatment of dermatologic disease other than psoriasis...
March 2014: Journal of Cutaneous Medicine and Surgery
Khor Jia Ker, Wei Sheng Chong, Colin Thiam Seng Theng
BACKGROUND: Actinic prurigo (AP) is a chronic, pruritic skin condition caused by an abnormal reaction to sunlight. AIMS: The aim of this study is to determine the clinical characteristics of AP in patients attending the National Skin Centre, Singapore, from 1 st January 1999 to 30 th June 2008. METHODS: Cases of AP diagnosed from 1 st January 1999 to 30 th June 2008 were retrieved from the center's electronic medical records and analyzed. RESULTS: A total of 11 patients were diagnosed with AP...
November 2013: Indian Journal of Dermatology, Venereology and Leprology
D P Thapa, A K Jha, C Kharel, S Shrestha
Geriatric health care has become a major issue worldwide. There are no data regarding geriatric dermatologic diseases are available from Nepal. Patients of 60 years and above were enrolled in the Nepali fiscal year 2067(April 2010-April 2011). The data included age, sex, place, and diagnosis. The aim of the study is to determine the characteristic pattern and frequency of dermatoses in dermatologic patients aged 60 years and above. There were total of 6442 patients who visited out patients department. Out of which frequency of geriatric patients were 330, which constitute about 5...
September 2012: Nepal Medical College Journal: NMCJ
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"