keyword
MENU ▼
Read by QxMD icon Read
search

Hiv origins

keyword
https://www.readbyqxmd.com/read/27930093/kir-gene-content-diversity-in-a-zimbabwean-population-does-kir2dl2-have-a-role-in-protection-against-human-immunodeficiency-virus-infection
#1
Kudakwashe Mhandire, Lynn Sodai Zijenah, Louis-Marie Yindom, Kerina Duri, Tommy Mlambo, Mqondisi Tshabalala, Lovemore Ronald Mazengera, Doreen Zvipo Mhandire, Cuthbert Musarurwa, Collet Dandara, Sarah Rowland-Jones, Hilda Tendisa Matarira, Babill Stray-Pedersen
Killer cell immunoglobulin-like receptors (KIRs) mediate natural killer cell function through interaction with their cognate human leukocyte antigen ligands. Thus, KIR gene variants have been implicated in resistance or susceptibility to viral infections. However, research on the role of these variants remains contradictory and inconclusive. In the present study, we investigated KIR gene content diversity and its association with human immunodeficiency virus (HIV) infection in an adult Black Zimbabwean population...
December 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27928907/separation-of-hiv-1-gag-virus-like-particles-from-vesicular-particles-impurities-by-hydroxyl-functionalized-monoliths
#2
Petra Steppert, Daniel Burgstaller, Miriam Klausberger, Petra Kramberger, Andres Tover, Eva Berger, Katharina Nöbauer, Ebrahim Razzazi-Fazeli, Alois Jungbauer
The downstream processing of enveloped virus-like particles is very challenging because of the biophysical and structural similarity between correctly assembled particles and contaminating vesicular particles present in the feedstock. We used hydroxyl-functionalized polymethacrylate monoliths, providing hydrophobic and electrostatic binding contributions, for the purification of HIV-1 gag virus-like particles. The clarified culture supernatant was conditioned with ammonium sulfate and after membrane filtration, loaded onto a 1 mL monolith...
December 8, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27927190/cd4-cell-counts-and-presence-of-aids-in-hiv-positive-patients-entering-specialized-care-a-comparison-of-migrant-groups-in-the-german-clinsurv-hiv-cohort-study-1999-2013
#3
Nadine Zeitlmann, Barbara Gunsenheimer-Bartmeyer, Claudia Santos-Hövener, Christian Kollan, Matthias An der Heiden
BACKGROUND: Although early presentation to HIV-care is essential to ensure timely initiation of antiretroviral therapy, recent studies have shown that especially migrants present to HIV-care at a later stage of HIV-infection. Currently, thirty percent of all newly diagnosed HIV cases in Germany originate from abroad. So far it is unknown, which specific migrant groups in Germany are particularly at risk for late presentation to HIV-care. METHODS: We used data from the Clinical Surveillance of HIV Disease (ClinSurv) cohort, a multi-centre observational cohort (01/01/1999 and 31/07/2013) and included treatment-naïve patients with valid information on country of origin and date of enrolment...
December 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27921633/healthcare-resources-are-inadequate-to-address-the-burden-of-illness-among-hiv-infected-male-prisoners-in-malaysia
#4
Joseph Bick, Gabriel Culbert, Haider A Al-Darraji, Clayton Koh, Veena Pillai, Adeeba Kamarulzaman, Frederick Altice
Purpose Criminalization of drug use in Malaysia has concentrated people who inject drugs (PWID) and people living with HIV into prisons where health services are minimal and HIV-related mortality is high. Few studies have comprehensively assessed the complex health needs of this population. The paper aims to discuss these issues. Design/methodology/approach From October 2012 through March 2013, 221 sequentially selected HIV-infected male prisoners underwent a comprehensive health assessment that included a structured history, physical examination, and clinically indicated diagnostic studies...
December 19, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27910750/antiretroviral-agents-looking-for-the-best-possible-chemotherapeutic-options-to-conquer-hiv
#5
Tahir Farooq, Arruje Hameed, Kanwal Rehman, Muhammad Ibrahim, Muhammad Imran Qadir, Muhammad Sajid Hamid Akash
For the last thirty years, ongoing efforts have revolutionized the antiretroviral therapy, which changed human immunodeficiency virus (HIV) infections from terrifying lethal diseases to chronic conditions. However, many challenges, like emergence of drug resistance, limited the scope of activity of currently existing anti-HIV agents. Quite often severe side effects and lifelong dependency are the major concerns of present era. All these issues have compelled the scientists to reconsider and refine the current therapies and also contemplate the pivotal priorities for the developments of novel therapeutic paradigms...
2016: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/27906024/rate-of-initial-highly-active-anti-retroviral-therapy-regimen-change-and-its-predictors-among-adult-hiv-patients-at-university-of-gondar-referral-hospital-northwest-ethiopia-a-retrospective-follow-up-study
#6
Degefaye Zelalem Anlay, Zinahbizu Abay Alemayehu, Berihun Assefa Dachew
BACKGROUND: Regimen change is a major challenge for the sustainability of human immunodeficiency virus (HIV) treatment program. In a resource limited setting where treatment options are limited, designing strategies to increase the durability of original regimen are essential. However, information's on rate of initial regimen change and its predictors is scarce in Ethiopia. Therefore, the purpose of this study was to assess the rate of initial highly active anti retroviral therapy (HAART) regimen change and its predictors among adult HIV patients at the University of Gondar Referral Hospital, Northwest Ethiopia...
February 17, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905351/-visualizing-research-lines-in-public-health-an-analysis-based-on-bibliometric-maps-applied-to-the-revista-espa%C3%A3-ola-de-salud-p%C3%A3%C2%BAblica-2006-2015
#7
Carmen Gálvez
OBJECTIVE: Identifying research lines is essential to understand the knowledge structure of a scientific domain. The aim of this study was to identify the main research topics of within the domain of public health, in the Revista Española de Saslud Pública during 2006-2015. METHODS: Original articles included in the Social Sciences Citation Index (SSCI) database, available online through the Web of Science (WoS), were selected. The analysis units used were the keywords, KeyWords Plus (KW+), extracted automatically by SSCI...
December 1, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27903354/-the-characteristics-of-hiv-positive-men-who-have-sex-with-men-in-china-and-predictors-of-their-migration-2008-2015
#8
Q Q Qin, W Guo, L Y Wang, Z W Ding, C Cai, Y Cui, J P Sun
Objective: To characterize the migration patterns of men who have sex with men (MSM) living with HIV/AIDS in the period 2008-2015 and to characterize the determinants of their migration. Methods: All identified HIV/AIDS cases transmitted through self-reported homosexual contact reported to the National Case Reporting System(CRS) by the end of December 31, 2015 were included in this study. Data of basic demographic characteristics, household registration and address of the research objects were collected. Retrospective cohort study was used to analyze the migration characteristics of HIV/AIDS cases between 2008 and 2015...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27903304/association-between-taenia-solium-infection-and-hiv-aids-in-northern-tanzania-a-matched-cross-sectional-study
#9
Veronika Schmidt, Christian Kositz, Karl-Heinz Herbinger, Hélène Carabin, Bernard Ngowi, Ezra Naman, Patricia P Wilkins, John Noh, William Matuja, Andrea Sylvia Winkler
BACKGROUND: The frequency of Taenia solium, a zoonotic helminth, is increasing in many countries of sub-Saharan Africa, where the prevalence of the human immunodeficiency virus (HIV) is also high. However, little is known about how these two infections interact. The aim of this study was to compare the proportion of HIV positive (+) and negative (-) individuals who are infected with Taenia solium (TSOL) and who present with clinical and neurological manifestations of cysticercosis (CC)...
December 1, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27902330/simian-immunodeficiency-virus-sivmac239-infection-and-simian-human-immunodeficiency-virus-shiv89-6p-infection-result-in-progression-to-aids-in-cynomolgus-macaques-from-asian-country-origin
#10
Tomotaka Okamura, Yusuke Tsujimura, Shogo Soma, Ichiro Takahashi, Kazuhiro Matsuo, Yasuhiro Yasutomi
Simian immunodeficiency virus (SIV) infection models in cynomolgus macaques are important for analysis of the pathogenesis of immunodeficiency virus and for studies on the efficacy of new vaccine candidates. However, very little is known about the pathogenesis of SIV or simian human immunodeficiency virus (SHIV) in cynomolgus macaques from different Asian country origins. In the present study, we analyzed the infectivity and pathogenicity of CCR5-tropic SIVmac and those of dual-tropic SHIV89.6P inoculated in cynomolgus macaques of Indonesia, Malaysia or Philippines origin...
October 21, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27898592/the-hepatitis-c-virus-nonstructural-protein-3-q80k-polymorphism-is-frequently-detected-and-transmitted-among-hiv-infected-msm-in-the-netherlands
#11
Astrid M Newsum, Cynthia K Y Ho, Faydra I Lieveld, Thijs J W van de Laar, Sylvie M Koekkoek, Sjoerd P Rebers, Jan T M van der Meer, Anne M J Wensing, Greet J Boland, Joop E Arends, Karel J van Erpecum, Maria Prins, Richard Molenkamp, Janke Schinkel
OBJECTIVES: The Q80K polymorphism is a naturally occurring resistance-associated variant in the hepatitis C virus (HCV) nonstructural protein 3 (NS3) region and is likely transmissible between hosts. This study describes the Q80K origin and prevalence among HCV risk groups in the Netherlands and examines whether Q80K is linked to specific transmission networks. DESIGN AND METHODS: Stored blood samples from HCV genotype 1a-infected patients were used for PCR and sequencing to reconstruct the NS3 maximum likelihood phylogeny...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27893830/mechanistic-studies-and-modeling-reveal-the-origin-of-differential-inhibition-of-gag-polymorphic-viruses-by-hiv-1-maturation-inhibitors
#12
Zeyu Lin, Joseph Cantone, Hao Lu, Beata Nowicka-Sans, Tricia Protack, Tian Yuan, Hong Yang, Zheng Liu, Dieter Drexler, Alicia Regueiro-Ren, Nicholas A Meanwell, Mark Cockett, Mark Krystal, Max Lataillade, Ira B Dicker
HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second generation MI with improved antiviral activity toward polymorphic Gag variants compared to a first generation MI bevirimat (BVM). The underlying mechanistic reasons for the differences in polymorphic coverage were studied using antiviral assays, an LC/MS assay that quantitatively characterizes CA/SP1 cleavage kinetics of virus like particles (VLPs) and a radiolabel binding assay to determine VLP/MI affinities and dissociation kinetics...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27892469/total-synthesis-of-feglymycin-based-on-a-linear-convergent-hybrid-approach-using-micro-flow-amide-bond-formation
#13
Shinichiro Fuse, Yuto Mifune, Hiroyuki Nakamura, Hiroshi Tanaka
Feglymycin is a naturally occurring, anti-HIV and antimicrobial 13-mer peptide that includes highly racemizable 3,5-dihydroxyphenylglycines (Dpgs). Here we describe the total synthesis of feglymycin based on a linear/convergent hybrid approach. Our originally developed micro-flow amide bond formation enabled highly racemizable peptide chain elongation based on a linear approach that was previously considered impossible. Our developed approach will enable the practical preparation of biologically active oligopeptides that contain highly racemizable amino acids, which are attractive drug candidates...
November 28, 2016: Nature Communications
https://www.readbyqxmd.com/read/27891651/developing-a-bayesian-adaptive-design-for-a-phase-i-clinical-trial-a-case-study-for-a-novel-hiv-treatment
#14
Alexina J Mason, Juan Gonzalez-Maffe, Killian Quinn, Nicki Doyle, Ken Legg, Peter Norsworthy, Roy Trevelion, Alan Winston, Deborah Ashby
The design of phase I studies is often challenging, because of limited evidence to inform study protocols. Adaptive designs are now well established in cancer but much less so in other clinical areas. A phase I study to assess the safety, pharmacokinetic profile and antiretroviral efficacy of C34-PEG4 -Chol, a novel peptide fusion inhibitor for the treatment of HIV infection, has been set up with Medical Research Council funding. During the study workup, Bayesian adaptive designs based on the continual reassessment method were compared with a more standard rule-based design, with the aim of choosing a design that would maximise the scientific information gained from the study...
November 27, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27888531/fate-of-microglia-during-hiv-1-infection-from-activation-to-senescence
#15
REVIEW
Natalie C Chen, Andrea T Partridge, Christian Sell, Claudio Torres, Julio Martín-García
Microglia support productive human immunodeficiency virus type 1 (HIV-1) infection and disturbed microglial function could contribute to the development of HIV-associated neurocognitive disorders (HAND). Better understanding of how HIV-1 infection and viral protein exposure modulate microglial function during the course of infection could lead to the identification of novel therapeutic targets for both the eradication of HIV-1 reservoir and treatment of neurocognitive deficits. This review first describes microglial origins and function in the normal central nervous system (CNS), and the changes that occur during aging...
November 26, 2016: Glia
https://www.readbyqxmd.com/read/27888382/-say-your-favorite-poet-in-the-world-is-lying-there-eileen-myles-james-schuyler-and-the-queer-intimacies-of-care
#16
Libbie Rifkin
This article closely reads "Chelsea Girls," an autobiographical short story by Eileen Myles that depicts her experience caring for the diabetic, bipolar poet James Schuyler when she was a young writer getting started in East Village in the late 1970s. Their dependency relationship is a form of queer kinship, an early version of the caring relations between lesbians and gay men that HIV/AIDS would demand over the next two decades as chosen families emerged to nurture gay men and lesbians rejected by their families of origin...
November 25, 2016: Journal of Medical Humanities
https://www.readbyqxmd.com/read/27888370/understanding-the-impact-of-migration-on-hiv-risk-an-analysis-of-mexican-migrants-sexual-practices-partners-and-contexts-by-migration-phase
#17
Xiao Zhang, Natalie Rhoads, Maria Gudelia Rangel, Melbourne F Hovell, Carlos Magis-Rodriguez, Carol L Sipan, J Eduardo Gonzalez-Fagoaga, Ana P Martínez-Donate
HIV risk among Mexican migrants varies across migration phases (pre-departure, transit, destination, interception, and return), but there is limited knowledge about specific sexual behaviors, characteristics of sexual partners, and sexual contexts at different migration stages. To fill the gap, we used data from a cross-sectional population-based survey conducted in Tijuana, Mexico. Information on migration phase and last sexual encounter was collected from 1219 male migrants. Our findings suggest that compared to pre-departure migrants, repeat migrants returning from communities of origin were more likely to have sex with male partners, use substances before sex, and not use condoms; migrants in the transit phase in the Mexican border were more likely to have sex with casual partners and sex workers; and migrants in the interception phase were more likely to engage in anal sex and use substances before sex...
November 25, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27873219/immortalization-of-primary-microglia-a-new-platform-to-study-hiv-regulation-in-the-central-nervous-system
#18
Yoelvis Garcia-Mesa, Taylor R Jay, Mary Ann Checkley, Benjamin Luttge, Curtis Dobrowolski, Saba Valadkhan, Gary E Landreth, Jonathan Karn, David Alvarez-Carbonell
The major reservoirs for HIV in the CNS are in the microglia, perivascular macrophages, and to a lesser extent, astrocytes. To study the molecular events controlling HIV expression in the microglia, we developed a reliable and robust method to immortalize microglial cells from primary glia from fresh CNS tissues and commercially available frozen glial cells. Primary human cells, including cells obtained from adult brain tissue, were transformed with lentiviral vectors expressing SV40 T antigen or a combination of SVR40 T antigen and hTERT...
November 21, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27870005/hiv-protease-inhibitors-for-the-treatment-of-cancer-repositioning-hiv-protease-inhibitors-while-developing-more-potent-no-hybridized-derivatives
#19
REVIEW
Danijela Maksimovic-Ivanic, Paolo Fagone, James McCubrey, Klaus Bendtzen, Sanja Mijatovic, Ferdinando Nicoletti
The possible use of HIV protease inhibitors (HIV-PI) as new therapeutic option for the treatment of cancer primarily originated from their success in treating HIV-related Kaposi's sarcoma (KS). While these findings were initially attributed to immune reconstitution and better control of oncogenic viral infections, the number of reports on solid tumors, KS, lymphoma, fibrosarcoma, multiple myeloma, and prostate cancer suggest other mechanisms for the anti-neoplastic activity of PIs. However, a major drawback for the possible adoption of HIV-PIs in the therapy of cancer relies on their relatively weak anticancer potency, and important side effects...
November 21, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27866834/-patient-0-and-the-origin-of-hiv-aids-in-america
#20
Zhen Gong, Xiaoyu Xu, Guan-Zhu Han
The origin of the HIV/AIDS epidemic in North America remains contentious. A recent study uses phylogenetic and historical approaches to investigate the early history of HIV-1 group M subtype B in North America and shows that 'Patient 0' is not the source of the North American HIV/AIDS epidemic.
November 17, 2016: Trends in Microbiology
keyword
keyword
40636
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"