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https://www.readbyqxmd.com/read/28914817/ledgf-p75-deficiency-increases-deletions-at-the-hiv-1-cdna-ends
#1
Murilo T D Bueno, Daniel Reyes, Manuel Llano
Processing of unintegrated linear HIV-1 cDNA by the host DNA repair system results in its degradation and/or circularization. As a consequence, deficient viral cDNA integration generally leads to an increase in the levels of HIV-1 cDNA circles containing one or two long terminal repeats (LTRs). Intriguingly, impaired HIV-1 integration in LEDGF/p75-deficient cells does not result in a correspondent increase in viral cDNA circles. We postulate that increased degradation of unintegrated linear viral cDNA in cells lacking the lens epithelium-derived growth factor (LEDGF/p75) account for this inconsistency...
September 15, 2017: Viruses
https://www.readbyqxmd.com/read/28914126/patient-navigators-effectively-support-hiv-infected-individuals-returning-to-the-community-from-jail-settings
#2
Janet J Myers, Kimberly A Koester, Mi-Suk Kang Dufour, Alison O Jordan, Jacqueline Cruzado-Quinone, Alissa Riker
Purpose Patient navigation is an evidence-based approach for enhancing medical and support service co-ordination and ensuring linkage to medical care for people living with HIV released from jail. The paper aims to discuss this issue. Design/methodology/approach This brief describes the benefits of patient navigation and issues to consider when implementing a navigator program. The authors use process data to describe the type and amount of navigation services delivered as part of a randomized study, the "The San Francisco Navigator Project...
September 11, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28914120/the-furthest-left-behind-the-urgent-need-to-scale-up-harm-reduction-in-prisons
#3
Gen Sander, Fionnuala Murphy
Purpose Raise awareness about the disproportionate impact of HIV and hepatitis C (HCV) on prisoners worldwide and the need for key harm reduction services such as needle and syringe programmes and opioid substitution therapy in prisons offer practical recommendations to assist policy makers in implementing or scaling up these services. The paper aims to discuss these issues. Design/methodology/approach This study is a desk review of existing data and evidence on HIV, HCV and harm reduction in prisons, analysis of political barriers and formulation of key policy recommendations...
September 11, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28912478/the-molecular-epidemiology-of-hiv-1-in-the-comunidad-valenciana-spain-analysis-of-transmission-clusters
#4
Juan Ángel Patiño-Galindo, Manoli Torres-Puente, María Alma Bracho, Ignacio Alastrué, Amparo Juan, David Navarro, María José Galindo, Dolores Ocete, Enrique Ortega, Concepción Gimeno, Josefina Belda, Victoria Domínguez, Rosario Moreno, Fernando González-Candelas
HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in the Comunidad Valenciana (CV, Spain) from a public health surveillance perspective. For this, we analysed 1804 HIV-1 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 and 2014. These sequences were subtyped and subjected to phylogenetic analyses in order to detect transmission clusters. In addition, univariate and multinomial comparisons were performed to detect epidemiological differences between HIV-1 subtypes, and risk groups...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903727/uptake-of-health-services-among-truck-drivers-in-south-africa-analysis-of-routine-data-from-nine-roadside-wellness-centres
#5
Samanta Tresha Lalla-Edward, Sydney Ncube, Paul Matthew, Catherine A Hankins, W D Francois Venter, Gabriela B Gomez
BACKGROUND: Long-distance truck drivers are occupationally susceptible to poor health outcomes. Their patterns of healthcare utilisation and the suitability of healthcare services available to them are not well documented. We report on truck driver healthcare utilisation across South Africa and characterise the client population of the clinics serving them for future service development. METHODS: We analysed anonymised data routinely collected over a two-year period at nine Roadside Wellness Centres...
September 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28902412/interventions-for-treating-tuberculous-pericarditis
#6
REVIEW
Charles S Wiysonge, Mpiko Ntsekhe, Lehana Thabane, Jimmy Volmink, Dumisani Majombozi, Freedom Gumedze, Shaheen Pandie, Bongani M Mayosi
BACKGROUND: Tuberculous pericarditis can impair the heart's function and cause death; long term, it can cause the membrane to fibrose and constrict causing heart failure. In addition to antituberculous chemotherapy, treatments include corticosteroids, drainage, and surgery. OBJECTIVES: To assess the effects of treatments for tuberculous pericarditis. SEARCH METHODS: We searched the Cochrane Infectious Diseases Group Specialized Register (27 March 2017); the Cochrane Central Register of Controlled Trials (CENTRAL), published in the Cochrane Library (2017, Issue 2); MEDLINE (1966 to 27 March 2017); Embase (1974 to 27 March 2017); and LILACS (1982 to 27 March 2017)...
September 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28888151/evaluation-of-the-ac-ok-mental-health-and-substance-abuse-screening-measure-in-an-international-sample-of-latino-immigrants
#7
Ligia M Chavez, Patrick E Shrout, Ye Wang, Francisco Collazos, Rodrigo Carmona, Margarita Alegría
BACKGROUND: Early detection and intervention in primary care is integral to behavioral health. Valid, practical screening assessments are scarce, particularly for non-English speaking populations. We address this need by evaluating the psychometric properties of the Spanish version of the AC-OK Screen for Co-occurring Disorders for first and second generation immigrant Latinos in Massachusetts, USA, and Madrid and Barcelona, Spain. METHODS: 567 Latino participants were recruited in waiting areas of clinics or by referral from Primary Care, Mental Health, Substance Use, and HIV Treatment Clinics, as well as Community Agencies...
August 24, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28886044/genetic-variants-in-cyp2b6-and-cyp2a6-explain-interindividual-variation-in-efavirenz-plasma-concentrations-of-hiv-infected-children-with-diverse-ethnic-origin
#8
Sandra Soeria-Atmadja, Emma Österberg, Lars L Gustafsson, Marja-Liisa Dahl, Jaran Eriksen, Johanna Rubin, Lars Navér
BACKGROUND: Approximately 2.6 million children live with HIV globally, and efavirenz (EFV) is one of the most widely used antiretroviral agents for HIV treatment in children and adults. There are concerns about the appropriateness of current EFV dosing and it has been discussed whether EFV dosing should be adapted according to genotype in children as suggested for adults. AIM: To investigate if pediatric EFV dosing should be guided by genetic variation in drug metabolizing enzymes rather than by body weight...
2017: PloS One
https://www.readbyqxmd.com/read/28882163/prevalence-and-significance-of-mycoplasma-genitalium-in-women-living-with-hiv-in-denmark
#9
Anne Marie Rosendahl Madsen, Kristina Thorsteinsson, Anne-Mette Lebech, Merete Storgaard, Terese L Katzenstein, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Lars Noerregaard Nielsen, Aase Bengaard Andersen, Jørgen Skov Jensen
OBJECTIVE: Mycoplasma genitalium (M. genitalium) is a sexually transmitted pathogen associated with urethritis, cervicitis, and pelvic inflammatory disease. Previous studies have shown a strong association between M. genitalium and HIV infection, therefore screening and treatment for M. genitalium has been suggested as part of HIV prevention strategies. The objective of this study was to determine the prevalence of M. genitalium in women living with HIV (WLWH) in Denmark, and to compare the result with data on symptoms from the lower abdomen, sexual habits and immune status...
September 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28879788/development-of-an-epitope-based-hiv-1-vaccine-strategy-from-hiv-1-lipopeptide-to-dendritic-based-vaccines
#10
Mathieu Surenaud, Christine Lacabaratz, Gérard Zurawski, Yves Lévy, Jean-Daniel Lelièvre
Development of a safe, effective and globally affordable Human Immunodeficiency Virus strain 1 (HIV-1) vaccine offers the best hope for future control of the HIV-1 pandemic. However, with the exception of the recent RV144 trial, which elicited a modest level of protection against infection, no vaccine candidate has shown efficacy in preventing HIV-1 infection or in controlling virus replication in humans. There is also a great need for a successful immunotherapeutic vaccine since combination antiretroviral therapy (cART) does not eliminate the reservoir of HIV-infected cells...
September 7, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28876686/management-of-failed-mitral-valve-replacement-the-durban-experience
#11
D Kistan, M Booysen, G Alexander, T E Madiba
BACKGROUND: Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve-related complications. METHOD: Study setting: Inkosi Albert Luthuli Central Hospital, a tertiary referral Hospital in Durban. Study population: All patients undergoing redo mechanical mitral valve replacement surgery between January 2005 and December 2014...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28875019/protein-crystallography-and-drug-discovery-recollections-of-knowledge-exchange-between-academia-and-industry
#12
REVIEW
Tom L Blundell
The development of structure-guided drug discovery is a story of knowledge exchange where new ideas originate from all parts of the research ecosystem. Dorothy Crowfoot Hodgkin obtained insulin from Boots Pure Drug Company in the 1930s and insulin crystallization was optimized in the company Novo in the 1950s, allowing the structure to be determined at Oxford University. The structure of renin was developed in academia, on this occasion in London, in response to a need to develop antihypertensives in pharma...
July 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28874261/malignancies-and-infection-due-to-the-human-immunodeficiency-virus-are-these-emerging-diseases
#13
M E Valencia Ortega
Since the start of the human immunodeficiency virus (HIV) epidemic, tumour disease among patients has been significant. The collection of malignancies can be divided primarily into 2 groups: those associated with HIV (all of which are related to viral diseases) and those not associated with HIV (only some of which are associated with viral diseases). The origin of these malignancies is multifactorial, and the main causes that have led to an increase in tumour disease are immunosuppression, coinfection with oncogenic viruses and life prolongation secondary to the use of antiretroviral therapy...
September 2, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28874213/differences-in-neurocognitive-impairment-among-hiv-infected-latinos-in-the-united-states
#14
María J Marquine, Anne Heaton, Neco Johnson, Monica Rivera-Mindt, Mariana Cherner, Cinnamon Bloss, Todd Hulgan, Anya Umlauf, David J Moore, Pariya Fazeli, Susan Morgello, Donald Franklin, Scott Letendre, Ron Ellis, Ann C Collier, Christina M Marra, David B Clifford, Benjamin B Gelman, Ned Sacktor, David Simpson, J Allen McCutchan, Igor Grant, Robert K Heaton
OBJECTIVES: Human immunodeficiency virus (HIV) disproportionately affects Hispanics/Latinos in the United States, yet little is known about neurocognitive impairment (NCI) in this group. We compared the rates of NCI in large well-characterized samples of HIV-infected (HIV+) Latinos and (non-Latino) Whites, and examined HIV-associated NCI among subgroups of Latinos. METHODS: Participants included English-speaking HIV+ adults assessed at six U.S. medical centers (194 Latinos, 600 Whites)...
September 6, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28872858/a-fast-and-reliable-thermodynamic-approach-for-determining-protonation-state-of-asp-dyad
#15
Jinfeng Huang, Bin Sun, Yuan Yao, Junjun Liu
The protonation state of asp dyad is significantly important in revealing enzymatic mechanism and developing drugs. However, it is hard to be determined by calculating free energy changes between possible protonation states, because the free energy changes due to protein conformational flexibility are usually much larger than that originated from the different locations of protons. Sophisticated and computationally expensive methods such as free energy perturbation, thermodynamic integration, and QM/MM are therefore usually used for this purpose...
September 5, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28870213/test-and-treat-approach-to-hiv-aids-a-primer-for-mathematical-modeling
#16
REVIEW
Kyeongah Nah, Hiroshi Nishiura, Naho Tsuchiya, Xiaodan Sun, Yusuke Asai, Akifumi Imamura
The public benefit of test-and-treat has induced a need to justify goodness for the public, and mathematical modeling studies have played a key role in designing and evaluating the test-and-treat strategy for controlling HIV/AIDS. Here we briefly and comprehensively review the essence of contemporary understanding of the test-and-treat policy through mathematical modeling approaches and identify key pitfalls that have been identified to date. While the decrease in HIV incidence is achieved with certain coverages of diagnosis, care and continued treatment, HIV prevalence is not necessarily decreased and sometimes the test-and-treat is accompanied by increased long-term cost of antiretroviral therapy (ART)...
September 5, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28857779/high-levels-of-postmigration-hiv-acquisition-within-nine-european-countries
#17
Debora Alvarez-Del Arco, Ibidun Fakoya, Christos Thomadakis, Nikos Pantazis, Giota Touloumi, Anne-Francoise Gennotte, Freke Zuure, Henrique Barros, Cornelia Staehelin, Siri Göpel, Christoph Boesecke, Tullio Prestileo, Alain Volny-Anne, Fiona Burns, Julia Del Amo
OBJECTIVE: We aimed to estimate the proportion of postmigration HIV acquisition among HIV-positive migrants in Europe. DESIGN: To reach HIV-positive migrants, we designed a cross-sectional study performed in HIV clinics. METHODS: The study was conducted from July 2013 to July 2015 in 57 clinics (nine European countries), targeting individuals over 18 years diagnosed in the preceding 5 years and born abroad. Electronic questionnaires supplemented with clinical data were completed in any of 15 languages...
September 10, 2017: AIDS
https://www.readbyqxmd.com/read/28851364/-always-paracetamol-they-give-them-paracetamol-for-everything-a-qualitative-study-examining-eastern-european-migrants-experiences-of-the-uk-health-service
#18
Hannah Madden, Jane Harris, Christian Blickem, Rebecca Harrison, Hannah Timpson
BACKGROUND: The enlargement of the European Union since 2004 has led to an increase in the number of Eastern European migrants living in the UK. The health of this group is under-researched though some mixed evidence shows they are at higher risk of certain physical health conditions such as heart attacks, strokes, HIV and alcohol use and have poorer mental health. This is compounded by poor or insecure housing, low pay, isolation and prejudice. We aimed to understand the health needs and health service experiences of the Eastern European population in a town in Northern England...
August 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28843432/association-of-baseline-body-composition-with-incomplete-immune-response-after-highly-active-antiretroviral-therapy-in-chinese-hiv-infected-adults
#19
Pengtao Sun, Wei Yu, Taisheng Li, Qiang Lin, Fuping Guo, Xiaohong Zhou, Guiying Du, Ying Xu, Wenmin Guan
The aim of this study was to assess whether baseline body composition was associated with incomplete immune response after highly active antiretroviral therapy in Chinese HIV-infected adults. The clinical efficiency of related factors was evaluated by the receiver operating characteristic (ROC) curve. Total-body composition was measured by dual-energy X-ray absorptiometry in HIV-infected adults. In this study, lean mass index (LMI), fat mass index, and bone mineral content/height ratio, which were adjusted by height from the original data, were analyzed...
August 23, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28832290/sexual-and-reproductive-health-outcomes-among-female-sex-workers-in-johannesburg-and-pretoria-south-africa-recommendations-for-public-health-programmes
#20
Mariette Slabbert, Francois Venter, Cynthia Gay, Corine Roelofsen, Samanta Lalla-Edward, Helen Rees
BACKGROUND: The sexual and reproductive health (SRH) status of female sex workers is influenced by a wide range of demographic, behavioural and structural factors. These factors vary considerably across and even within settings. Adopting an overly standardised approach to sex worker programmes may compromise its impact on some sub-groups in local areas. METHODS: Records of female sex workers attending clinic-, community-, or hotel-based health services in Johannesburg (n = 1422 women) and Pretoria (n = 408 women), South Africa were analysed...
July 4, 2017: BMC Public Health
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