keyword
https://read.qxmd.com/read/38536563/machine-learning-in-risk-prediction-of-continuous-renal-replacement-therapy-after-coronary-artery-bypass-grafting-surgery-in-patients
#1
JOURNAL ARTICLE
Qian Zhang, Peng Zheng, Zhou Hong, Luo Li, Nannan Liu, Zhiping Bian, Xiangjian Chen, Hengfang Wu, Sheng Zhao
OBJECTIVES: This study aimed to develop machine learning models for risk prediction of continuous renal replacement therapy (CRRT) following coronary artery bypass grafting (CABG) surgery in intensive care unit (ICU) patients. METHODS: We extracted CABG patients from the electronic medical record system of the hospital. The endpoint of this study was the requirement for CRRT after CABG surgery. The Boruta method was used for feature selection. Seven machine learning algorithms were developed to train models and validated using 10 fold cross-validation (CV)...
March 27, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38536153/prognostic-models-for-mortality-and-morbidity-in-heart-failure-with-preserved-ejection-fraction
#2
JOURNAL ARTICLE
Kirsty McDowell, Toru Kondo, Atefeh Talebi, Ken Teh, Erasmus Bachus, Rudolf A de Boer, Ross T Campbell, Brian Claggett, Ashkay S Desai, Kieran F Docherty, Adrian F Hernandez, Silvio E Inzucchi, Mikhail N Kosiborod, Carolyn S P Lam, Felipe Martinez, Joanne Simpson, Muthiah Vaduganathan, Pardeep S Jhund, Scott D Solomon, John J V McMurray
IMPORTANCE: Accurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions. OBJECTIVE: To develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach. DESIGN, SETTING, AND PARTICIPANTS: Data were used from the Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure (DELIVER) trial to derive the prediction model, and data from the Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction (PARAGON-HF) and the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-PRESERVE) trials were used to validate it...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38535432/assessment-of-the-relationship-between-periodontitis-and-cardiac-parameters-in-patients-with-early-chronic-heart-failure-a-cross-sectional-study
#3
JOURNAL ARTICLE
Antina Schulze, Stefan Kwast, Christoph Pökel, Martin Busse
Periodontal disease (PD) is considered a risk factor for cardiovascular events. However, its relationship to chronic heart failure (CHF) is unclear. The aim was to compare cardiac and inflammatory parameters in CHF patients with (PG) versus without periodontitis (NPG). The following parameters were recorded in 58 patients: periodontal screening and recording (PSR), troponin T, NT-proBNP, C-reactive protein (CRP), interleukin-6 (IL-6), blood pressure, heart rate, ejection fraction (EF), ventricular systolic and diastolic function parameters, incremental test, and three questionnaires (Mediterranean Diet Adherence Screener, MEDAS; Oral Health Impact Profile, OHIP-14; Patient Health Questionnaire, PHQ)...
March 18, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38532515/inflammation-and-acute-cardiotoxicity-in-adult-hematological-patients-treated-with-car-t-cells-results-from-a-pilot-proof-of-concept-study
#4
JOURNAL ARTICLE
Massimiliano Camilli, Marcello Viscovo, Tamara Felici, Luca Maggio, Federico Ballacci, Giacomo Carella, Alice Bonanni, Priscilla Lamendola, Lorenzo Tinti, Antonio Di Renzo, Giulia Coarelli, Eugenio Galli, Giovanna Liuzzo, Francesco Burzotta, Rocco Antonio Montone, Federica Sorà, Simona Sica, Stefan Hohaus, Gaetano Antonio Lanza, Filippo Crea, Antonella Lombardo, Giorgio Minotti
AIMS: Chimeric Antigen Receptor-T (CAR-T) cell infusion is a rapidly evolving antitumor therapy; however, cardiovascular (CV) complications, likely associated with cytokine release syndrome (CRS) and systemic inflammation, have been reported to occur. The CARdio-Tox study aimed at elucidating incidence and determinants of cardiotoxicity related to CAR-T cell therapy. METHODS: Patients with blood malignancies candidate to CAR-T cells were prospectively evaluated by echocardiography at baseline and 7 and 30 days after infusion...
March 27, 2024: Cardio-Oncology
https://read.qxmd.com/read/38532263/diagnostic-and-prognostic-value-of-cardiac-troponins-in-emergency-department-patients-presenting-after-a-fall-a-prospective-multicenter-study
#5
JOURNAL ARTICLE
Tanguy Espejo, Lukas Terhalle, Alexandra Malinovska, Henk B Riedel, Laura Arntz, Livia Hafner, Karen Delport-Lehnen, Joanna Zuppinger, Nicolas Geigy, Jörg Leuppi, Rajan Somasundaram, Roland Bingisser, Christian H Nickel
BACKGROUND: Emergency department (ED) presentations after a ground-level fall (GLF) are common. Falls were suggested to be another possible presenting feature of a myocardial infarction (MI), as unrecognized MIs are common in older adults. Elevated high-sensitivity cardiac troponin (hs-cTn) concentrations could help determine the etiology of a GLF in ED. We investigated the prevalence of both MI and elevated high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI), as well as the diagnostic accuracy of hs-cTnT and hs-cTnI regarding MI, and their prognostic value in older ED patients presenting after a GLF...
March 26, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38531618/high-sensitive-troponint-interleukin-8-and-interleukin-6-link-with-post-surgery-risk-in-infant-heart-surgery
#6
JOURNAL ARTICLE
Elin M Thorlacius, Juho Keski-Nisula, Maria Vistnes, Tiina Ojala, Mattias Molin, Mats Synnergren, Birgitta S Romlin, Sven-Erik Ricksten, Håkan Wåhlander, Albert Gyllencreutz Castellheim
BACKGROUND: This study focuses on biomarkers in infants after open heart surgery, and examines the association of high-sensitive troponin T (hs-cTnT), interleukin-6 (IL-6), and interleukin-8 (IL-8) with postoperative acute kidney injury (AKI), ventilatory support time and need of vasoactive drugs. METHODS: Secondary exploratory study from a double-blinded clinical randomized trial (Mile-1) on 70 infants undergoing open heart surgery with cardiopulmonary bypass (CPB)...
March 26, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38528469/a-nomogram-model-for-predicting-intramyocardial-hemorrhage-post-pci-based-on-syntax-score-and-clinical-features
#7
JOURNAL ARTICLE
Yin-Shuang Yang, De-Yang Xi, Yang Duan, Miao Yu, Kai Liu, Yan-Kai Meng, Chun-Feng Hu, Shu-Guang Han, Kai Xu
OBJECTIVE: The aim of this study is to develop a nomogram model for predicting the occurrence of intramyocardial hemorrhage (IMH) in patients with Acute Myocardial Infarction (AMI) following Percutaneous Coronary Intervention (PCI). The model is constructed utilizing clinical data and the SYNTAX Score (SS), and its predictive value is thoroughly evaluated. METHODS: A retrospective study was conducted, including 216 patients with AMI who underwent Cardiac Magnetic Resonance (CMR) within a week post-PCI...
March 25, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38524002/mutation-of-pten-loss-and-likelihood-of-being-a-non-responder-to-trastuzumab-in-a-sample-of-iraqi-her2-breast-cancer-patients
#8
JOURNAL ARTICLE
Alyaa H Hammadi, Shatha H Ali
INTRODUCTION: PTEN controls upstream PI3K relatives, such as AKT. PTEN gene mutations have been documented to affect outcomes in main or distant malignancies, including breast cancer (BC). PTEN gene deletions are common in a variety of human cancers. A key factor in the response to this kind of therapy is genetic diversity. The purpose of this research is to determine whether a PTEN loss mutation influences a patient's propensity to not respond to trastuzumab (TRS) in cases of Her2+ BC...
February 2024: Curēus
https://read.qxmd.com/read/38523980/myocardial-bridging-of-mid-left-anterior-descending-artery-lad-presenting-as-transient-left-bundle-branch-block-during-nuclear-stress-test
#9
Kai Shiang Lin, Adam Kurnick, Ridhima Goel, Igal Gorbut, Adam Friedman, Ezra Schrem, Samy I McFarlane, Inna Bukharovich
Transient left bundle branch block occurring during a nuclear stress test in the setting of myocardial bridging is a relatively rare finding. We report a case of a 75-year-old male who presented with typical stable angina. Serial troponins were negative, and the electrocardiogram revealed normal sinus rhythm with left ventricular hypertrophy and T-wave inversions in the lateral leads. The nuclear stress test was non-ischemic but showed a transient left bundle branch block associated with chest pain and shortness of breath that occurred right after the administration of regadenoson...
February 2024: Curēus
https://read.qxmd.com/read/38523340/lymphocytic-myocarditis-with-increased-left-ventricular-thickness-a-rare-presentation-mimicking-cardiac-amyloidosis
#10
JOURNAL ARTICLE
Xueting Duan, Liangzhen Qu, Han Chen
BACKGROUND Lymphocytic myocarditis is an inflammatory condition of the heart that may present with a wide spectrum of symptoms and signs, ranging from asymptomatic to life-threatening cardiogenic shock and ventricular arrhythmia. Lymphocytic myocarditis usually presents as chamber dilation. However, increased left ventricular thickness is relatively rare. We present a case of lymphocytic myocarditis with increased left ventricular thickness which mimics the presentation of cardiac amyloidosis. CASE REPORT An 80-year-old Chinese man presented to the emergency room due to recurrent chest tightness...
March 25, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38521068/the-central-role-of-natural-killer-cells-in-mediating-acute-myocarditis-after-mrna-covid-19-vaccination
#11
JOURNAL ARTICLE
Hing Wai Tsang, Mike Yat Wah Kwan, Gilbert T Chua, Sabrina Siu Ling Tsao, Joshua Sung Chih Wong, Keith Tsz Suen Tung, Godfrey Chi Fung Chan, Kelvin Kai Wang To, Ian Chi Kei Wong, Wing Hang Leung, Patrick Ip
BACKGROUND: Vaccine-related acute myocarditis is recognized as a rare and specific vaccine complication following mRNA-based COVID-19 vaccinations. The precise mechanisms remain unclear. We hypothesized that natural killer (NK) cells play a central role in its pathogenesis. METHODS: Samples from 60 adolescents with vaccine-related myocarditis were analyzed, including pro-inflammatory cytokines, cardiac troponin T, genotyping, and immunophenotyping of the corresponding activation subsets of NK cells, monocytes, and T cells...
March 15, 2024: Med
https://read.qxmd.com/read/38516812/mechanisms-of-hypoxia-and-contractile-dysfunction-in-ischemia-reperfusion-in-hipsc-cardiomyocytes-an-in-silico-study
#12
JOURNAL ARTICLE
Mohamadamin Forouzandehmehr, Michelangelo Paci, Jari Hyttinen, Jussi T Koivumäki
Interconnected mechanisms of ischemia-reperfusion (I-R) has increased the interest in I-R in vitro experiments using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). We developed a whole-cell computational model of hiPSC-CMs including the electromechanics, a metabolite-sensitive sarcoplasmic reticulum Ca2+-ATPase (SERCA), and an oxygen dynamics formulation to investigate I-R mechanisms. Moreover, we simulated the effect and action mechanism of Levosimendan (LEVO) that recently showed promising anti-arrhythmic effects in hiPSC-CMs in hypoxia...
March 22, 2024: Disease Models & Mechanisms
https://read.qxmd.com/read/38510953/covid-myocarditis-in-a-collegiate-athlete-timeline-and-return-to-play
#13
JOURNAL ARTICLE
Katherine M Edenfield, Michael C Dillon, James R Clugston
BACKGROUND: Studies in collegiate athletes have demonstrated a prevalence of cardiac involvement between 0.5 and 3 % after SARS-CoV-2 infection. When post-COVID cardiac involvement occurs in athletes, the ideal return to play timeline and many possible long-term sequela or complications are unknown. CASE SUMMARY: A 20 yo female collegiate athlete tested positive for SARS-CoV-2 and underwent routine cardiac screening prior to her return to play (RTP). Evaluation demonstrated an elevated high-sensitivity troponin-I and an ECG showed some mild T wave changes...
October 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510283/high-sensitivity-cardiac-troponin-i-for-long-term-cardiovascular-risk-stratification-in-a-cancer-clinic-population
#14
JOURNAL ARTICLE
Peter A Kavsak, Joshua O Cerasuolo, David Kirkwood, Richard Perez, Hsien Seow, Jinhui Ma, Andrew Worster, Dennis T Ko, Sukhbinder Dhesy-Thind, Darryl Leong
No abstract text is available yet for this article.
February 2024: JACC CardioOncology
https://read.qxmd.com/read/38508657/comparison-of-troponin-and-natriuretic-peptides-in-takotsubo-syndrome-and-acute-coronary-syndrome-a-meta-analysis
#15
JOURNAL ARTICLE
Liam Steven Couch, James W Garrard, John A Henry, Rafail A Kotronias, Bashir Alaour, Giovanni Luigi De Maria, Keith M Channon, Adrian P Banning, Alexander Richard Lyon, Michael Marber, Thomas Edward Kaier
OBJECTIVE: Takotsubo syndrome (TTS) is an acute heart failure syndrome which resembles acute coronary syndrome (ACS) at presentation. Differentiation requires coronary angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. We performed a meta-analysis to compare troponin and natriuretic peptides (NPs) in TTS and ACS to determine if differences in biomarker profile can aid diagnosis. METHODS: We searched five literature databases for studies reporting NPs (Brain NP (BNP)/NT-pro-BNP) or troponin I/T in TTS and ACS, identifying 28 studies for troponin/NPs (5618 and 1145 patients, respectively)...
March 19, 2024: Open Heart
https://read.qxmd.com/read/38506504/clinical-and-laboratory-biomarkers-as-predictors-of-severity-in-pediatric-inflammatory-multisystem-syndrome-temporally-associated-with-sars-cov-2-data-from-a-prospective-nationwide-surveillance-study-in-switzerland
#16
JOURNAL ARTICLE
Juliane Wurm, Anita Uka, Michael Buettcher, Lisa Kottanattu, Nina Schöbi, Johannes Trück, Reto Villiger, Nicole Ritz, Petra Zimmermann
BACKGROUND: PIMS-TS (pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2) is a rare but serious condition in children following SARS-CoV-2 infection, characterized by a range of clinical symptoms with varying severity. Understanding risk factors for severe PIMS-TS is crucial for appropriate and timely intervention. OBJECTIVE: To identify factors associated with increased PIMS-TS severity in children. METHODS: In this nationwide prospective observational study, epidemiological and clinical data was collected from children <18 years of age with suspected or confirmed PIMS-TS from all 29 pediatric hospitals in Switzerland...
March 20, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38504577/routine-screening-for-hla-antibodies-in-heart-transplant-patients-does-it-affect-clinical-decision-making
#17
JOURNAL ARTICLE
Tor Skibsted Clemmensen, Johanne Hjort Baatrup, Kamilla Pernille Bjerre, Emil Lichscheidt, Pernille Koefoed Nielsen, Hans Eiskjaer
BACKGROUND: We aimed to assess outcomes in patients with and without donor specific antibodies (DSA) and to evaluate the relationship between DSA presence and graft function, cardiac allograft vasculopathy (CAV), and mortality. METHODS: The study population comprises 193 consecutive long-term heart transplanted (HTx) patients who underwent DSA surveillance between 2016 and 2022. The patients were prospectively screened for CAV through serial coronary angiograms, graft function impairment through serial echocardiograms, and cardiac biomarkers...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38504166/association-between-preoperative-frailty-and-myocardial-injury-after-noncardiac-surgery-in-geriatric-patients-study-protocol-for-a-prospective-multicentre-real-world-observational-cohort-trial
#18
JOURNAL ARTICLE
Yongtao Sun, Na Guo, Min Zhang, Mengjie Liu, Zhongquan Gao, Tao Sun, Xiaojun Gao, Lingling Xu, Haixia Zhang, Chuansong Wei, Peng Liu, Yang Liu, Xiaoning Zhang, Yongle Guo, Lina Chen, Zheng Zhou, Zhenqiang Su, Yanmei Hu, Xin Shi, Linlin Huang, Yuelan Wang
INTRODUCTION: Frailty has become a worldwide health burden that has a large influence on public health and clinical practice. The incidence of frailty is anticipated to increase as the ageing population increases. Myocardial injury after noncardiac surgery (MINS) is associated with short-term and long-term mortality. However, the incidence of MINS in frail geriatric patients is unknown. METHODS AND ANALYSIS: This prospective, multicentre, real-world observational cohort study will be conducted at 18 designated centres in China from January 2023 to December 2024, with an anticipated sample size of 856 patients aged 65 years and older who are scheduled to undergo noncardiac surgery...
March 19, 2024: BMC Geriatrics
https://read.qxmd.com/read/38503830/troponin-t-is-elevated-in-a-relevant-proportion-of-patients-with-5q-associated-spinal-muscular-atrophy
#19
JOURNAL ARTICLE
Hanna Sophie Lapp, Maren Freigang, Johannes Friese, Sarah Bernsen, Victoria Tüngler, Maja von der Hagen, Patrick Weydt, René Günther
Troponin T concentration (TNT) is commonly considered a marker of myocardial damage. However, elevated concentrations have been demonstrated in numerous neuromuscular disorders, pointing to the skeletal muscle as a possible extracardiac origin. The aim of this study was to determine disease-related changes of TNT in 5q-associated spinal muscular atrophy (SMA) and to screen for its biomarker potential in SMA. We therefore included 48 pediatric and 45 adult SMA patients in this retrospective cross-sequential observational study...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38501407/-colchicine-alleviates-myocardial-ischemia-reperfusion-injury-in-mice-by-activating-ampk
#20
JOURNAL ARTICLE
G Chen, S Luo
OBJECTIVE: To investigate the protective effect of colchicine against myocardial ischemia-reperfusion injury (I/R) and explore the underlying mechanism. METHODS: H9C2 cells exposed to hypoxia/reoxygenation (H/R) were treated with 3 nmol/L colchicine, after which the changes in cell viability were assessed using MTT assay, and AMPK phosphorylation, the expressions of NOX4, NRF2, SOD2, BAX, Bcl-2, and cleaved caspase-3 were detected with Western blotting. Male C57BL/6 mice were randomized into sham operation, I/R, I/R+colchicine, and I/R+colchicine+dorsomorphin (DSMP) groups...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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