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https://www.readbyqxmd.com/read/29453928/cd4-cd25-cd127low-foxp3-regulatory-t-cells-in-crohn-s-disease
#1
Ali Khalili, Soheil Ebrahimpour, Iradj Maleki, Saeid Abediankenari, Mousa Mohammadnia Afrouzi
BACKGROUND: Regulatory T (Treg) cell play a key role in autoimmune diseases. We evaluated the regulatory function and frequency of Treg cells and secreted IL-10, IL-35 concentration in Crohn's disease (CD). METHODS: Twenty-three patients with CD and 25 healthy controls (HC) were included in this study. We analysed the alteration of Tregs frequency using flow cytometry for CD4, CD25, CD127 and FoxP3 markers. Surface expression of CD4, CD25 and CD127 markers were used for isolation of a relatively pure Treg cells...
February 16, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29453848/postoperative-recurrence-of-crohn-s-disease-pathophysiology-diagnosis-and-treatment
#2
Antonio Di Sario, Paola Sassaroli, Luigi Daretti, Giulia Annulli, Laura Schiada, Giorgia Falcioni, Emanuele Bendia, Simone Antuono, Antonio Benedetti
BACKGROUND: Up to 80% of Crohn`s disease (CD) patients require at least one surgical intervention in their lifetime and up to 70% of these patients develop postoperative endoscopic recurrence within 1 year. The most important predictors of early postoperative recurrence are represented by smoking, prior intestinal surgery, penetrating disease and perianal location. Genetic factors, gut microbiota structure and immunological alterations may be involved in the pathogenesis of postoperative recurrence of CD, although their specific roles have to be determined yet...
February 16, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29452228/a-bach2-gene-variant-is-associated-with-postoperative-recurrence-of-crohn-s-disease
#3
Michael R Laffin, Richard N Fedorak, Eytan Wine, Bryan Dicken, Karen L Madsen
BACKGROUND: Crohn's disease often requires intestinal resection, which is not considered curative. Repeat surgical intervention is necessary in over half of the patients following their initial operation. Although many genetic loci are implicated in Crohn's disease, few have been associated with post-resection recurrence. STUDY DESIGN: A cohort of Crohn's disease subjects who underwent intestinal resection was analyzed to determine genetic and clinical factors associated with post-resection recurrence...
February 13, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29451523/-towards-new-therapeutic-paradigms-beyond-symptom-control-in-the-management-of-inflammatory-bowel-diseases
#4
Stefano Festa, Giulia Zerboni, Annalisa Aratari, Riccardo Ballanti, Claudio Papi
Inflammatory bowel diseases, Crohn's disease and ulcerative colitis are chronic relapsing conditions that may result in progressive bowel damage, high risk of complications, surgery and permanent disability. The conventional therapeutic approach for inflammatory bowel diseases is based mainly on symptom control. Unfortunately, a symptom-based therapeutic approach has little impact on major long-term disease outcomes. In other chronic disabling conditions such as diabetes, hypertension and rheumatoid arthritis, the development of new therapeutic approaches has led to better outcomes...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29449505/detection-of-crohn-disease-in-patients-with-spondyloarthropathy-the-space-capsule-study
#5
Uri Kopylov, Michael Starr, Craig Watts, Serge Dionne, Marc Girardin, Ernest G Seidman
OBJECTIVE: Inflammatory bowel disease (IBD) is generally reported to be associated with spondylarthropathies (SpA) in 5%-15% of cases. Systematic colonoscopic assessment by protocol demonstrated mucosal inflammation characteristic of Crohn disease (CD) in up to one-third of patients with SpA. Video capsule endoscopy (CE) is a superior diagnostic tool to detect small bowel mucosal disease. Our study compared the accuracy of CE to standard colonoscopy for detection of inflammatory bowel lesions in patients with SpA, and to describe predictors of small bowel inflammation (SBI) in this cohort...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29448862/filgotinib-for-the-treatment-of-crohn-s-disease
#6
Remi Labetoulle, Stephane Paul, Xavier Roblin
Inflammatory Bowel Diseases, such as Crohn's disease (CD) and Ulcerative Colitis (UC), are widespread diseases (with an estimated 2.2 million Europeans affected), and even populations previously considered 'low risk' (such as Japan and India) are witnessing an increasing incidence. CD is a chronic, progressive immunologically driven disease, with an evolution characterized by succession of periods of progression and remission. New physiopathological pathways are continuously being discovered, the more we understand about how the disease appears and progresses, the more targets become available for the development of novel therapies...
February 15, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29447645/vulvar-metastatic-crohn-disease-clinical-histopathological-and-ultrasonographic-findings
#7
María Pousa-Martínez, Fernando Alfageme, María Antonia González de Domingo, Dolores Suárez-Masa, Marta Calvo, Gastón Roustán
Metastatic Crohn disease (MCD) is an unusual type of cutaneous Crohn disease characterized by skin lesions separated from the lesions of the gastrointestinal tract. The diagnosis of MCD is essentially histological,showing noncaseating granulomas in the dermis and subcutaneous fat tissue. We report a case of MCD with vulvar involvement and clinical, histopathological, and ultrasonographic findings of this disease.
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447637/crohn-disease-associated-neutrophilic-urticarial-dermatosis-report-and-literature-review-of-neutrophilic-urticarial-dermatosis
#8
Zhe Hou, Brian R Hinds, Philip R Cohen
Neutrophilic urticarial dermatosis (NUD) is a useful diagnostic term for urticarial lesions that are less pruritic and more painful than conventional urticaria. The histopathologic features include neutrophilic infiltrates in the interstitial dermis with a higher density than idiopathic urticaria. NUD has been associated with several systemic conditions, which are predominantly autoimmune and autoinflammatory in nature. A woman with Crohn disease who developed NUD is described. Literature reports of other conditions in which neutrophilic urticarial dermatosis have been observed are also reviewed and summarized...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447487/perianal-crohn-s-disease-association-with-significant-inflammatory-activity-in-proximal-small-bowel-segments
#9
Sofia Xavier, Tiago Cúrdia Gonçalves, Francisca Dias de Castro, Joana Magalhães, Bruno Rosa, Maria João Moreira, José Cotter
OBJECTIVES: Perianal Crohn's disease (CD) prevalence varies according to the disease location, being particularly frequent in patients with colonic involvement. We aimed to evaluate small bowel involvement and compare small bowel capsule endoscopy findings and inflammatory activity between patients with and without perianal disease. MATERIALS AND METHODS: Retrospective single-center study including 71 patients - all patients with perianal CD (17 patients) who performed a small bowel capsule endoscopy were included, and non-perianal CD patients were randomly selected (54 patients)...
February 15, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29447283/gp96-deficiency-affects-tlr4-functionality-and-impairs-erk-and-p38-phosphorylation
#10
Jesus Cosin-Roger, Marianne R Spalinger, Pedro A Ruiz, Claudia Stanzel, Anne Terhalle, Lutz Wolfram, Hassan Melhem, Kirstin Atrott, Silvia Lang, Isabelle Frey-Wagner, Michael Fried, Michael Scharl, Martin Hausmann, Gerhard Rogler
Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn's disease (CD) patients is correlated with loss of tolerance against the host gut flora. Gp96 has been stablished to be an essential chaperone for Toll-like receptors (TLRs). We studied the impact of gp96-knockdown on TLR-function in macrophages. TLR2 and TLR4 expression was only decreased but not abolished when gp96 was knocked-down in cell lines, whereas in a monocyte/macrophage specific knock-out mouse model (LysMCre) TLR4 was abolished, while TLR2 was still present...
2018: PloS One
https://www.readbyqxmd.com/read/29447146/health-risk-behaviors-and-chronic-conditions-among-adults-with-inflammatory-bowel-disease-united-states-2015-and-2016
#11
Fang Xu, James M Dahlhamer, Emily P Zammitti, Anne G Wheaton, Janet B Croft
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. In 2015, an estimated 3.1 million adults in the United States had ever received a diagnosis of IBD (1). Nationally representative samples of adults with IBD have been unavailable or too small to assess relationships between IBD and other chronic conditions and health-risk behaviors (2). To assess the prevalence of health-risk behaviors and chronic conditions among adults with and without IBD, CDC aggregated survey data from the 2015 and 2016 National Health Interview Survey (NHIS)...
February 16, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29446858/enteral-nutrition-for-pediatric-crohn-s-disease-an-underutilized-therapy
#12
REVIEW
Ala K Shaikhkhalil, Wallace Crandall
Enteral nutrition (EN) for the treatment of Crohn's disease (CD) involves administration of a liquid nutrition product, administered orally or through tube feeding, while excluding typical dietary components. It is a safe and effective, but largely underused, therapy in the United States as a treatment for CD. EN is a particularly attractive option for pediatric CD as it avoids side effects of corticosteroids, improves growth, and may have a higher likelihood of achieving mucosal healing than some traditional medications...
February 15, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29446812/surgical-management-of-primary-crohn-s-disease-descriptive-study-about-226-patients
#13
Amin Makni, Houcine Magherbi, Azza El Heni, Anis Haddad, Amin Daghfouss, Wael Rebai, Faouzi Chebbi, Rachid Ksantini, Fadhel Fterich, Mohamed Jouini, Montasser Kacem, Nabil Ben Mami, Azza Filali, Zoubeir Ben Safta
BACKGROUND: The surgery is required in more than 80% of patients with Crohn's disease (CD). Studies before confirm the specific genetic variation of CD in the Tunisian population compared with the others ethnic groups. AIM: This article aims to study the epidemiological, anatomical and therapeutic principles of surgical forms of CD in a cohort of Tunisian patients. METHODS: We report a retrospective study from January 1998 to September 2010 that studied 226 patients originated only from Tunisia (in North Africa), operated on for MC...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29446764/antibodies-against-glycoprotein-2-display-diagnostic-advantages-over-asca-in-distinguishing-cd-from-intestinal-tuberculosis-and-intestinal-beh%C3%A3-et-s-disease
#14
Shulan Zhang, Jing Luo, Ziyan Wu, Dirk Roggenbuck, Peter Schierack, Dirk Reinhold, Ji Li, Xiaofeng Zeng, Fengchun Zhang, Jiaming Qian, Yongzhe Li
OBJECTIVES: There is an increasing need to identify reliable biomarkers for distinguishing Crohn's disease (CD) from other gastrointestinal disorders sharing similar clinical and pathological features. This study aimed at evaluating the diagnostic potential of antibodies to zymogen granule glycoprotein GP2 (aGP2) in a large, well-defined Chinese cohort with a special focus on their role in discriminating CD from intestinal Behçet's disease (BD) and intestinal tubercolosis (ITB). METHODS: A total of 577 subjects were prospectively enrolled, including 171 patients with CD, 208 patients with ulcerative colitis (UC), 71 with BD, 57 with ITB and 70 healthy controls (HC)...
February 15, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29446723/immunomodulatory-effects-of-flavonoids-in-the-prophylaxis-and-treatment-of-inflammatory-bowel-diseases-a-comprehensive-review
#15
Daniela Ribeiro, Carina Proenca, Silvia Rocha, Jose L F C Lima, Felix Carvalho, Eduarda Fernandes, Marisa Freitas
Inflammatory bowel diseases (IBD) comprise two disorders of idiopathic chronic intestinal inflammation that affect about three million people worldwide: Crohn's disease and ulcerative colitis. Nowadays, the first-line of treatment for patients with mild to moderate symptoms of IBD comprises corticosteroids, immunosuppressants, antibiotics, and biological agents. Unfortunately, none of these drugs are curative, and their long-term use may cause severe side effects and complications. Almost 40% of IBD patients use alternative therapies to complement the conventional one, and flavonoids are gaining attention for this purpose...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29446656/crohn-s-disease-candidate-gene-alleles-predict-time-to-progression-from-inflammatory-b1-to-stricturing-b2-or-penetrating-b3-phenotype
#16
Cvetka Pernat Drobež, Ivan Ferkolj, Uroš Potočnik, Katja Repnik
AIM: Crohn's disease (CD) patients are mostly diagnosed with the uncomplicated inflammatory form of disease; however, the majority of them will progress to complicated stricturing or penetrating disease over time. It is important to identify patients at risk for disease progression at an early stage. The aim of our study was to examine the role of 33 candidate CD genes as possible predictors of disease progression and their influence on time to progression from an inflammatory to a stricturing or penetrating phenotype...
February 15, 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29445293/clinical-utility-of-ustekinumab-in-crohn-s-disease
#17
REVIEW
Paulo Gustavo Kotze, Christopher Ma, Abdulelah Almutairdi, Remo Panaccione
The introduction of anti-tumor necrosis factor (TNF) therapy marked an important milestone in the management of moderate-to-severe Crohn's disease (CD). However, there remains a pressing demand for alternative therapeutic options for patients with primary nonresponse, secondary loss of response, or intolerable side effects to conventional treatment and TNF antagonists. Ustekinumab (UST) is a fully human IgG1κ monoclonal antibody that inhibits the p40 subunit shared by the proinflammatory cytokines, the interleukin (IL)-12 and -23...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29442063/bowel-perforation-in-crohn-s-disease-correlation-between-cdai-and-clavien-dindo-scores
#18
T Fontana, N Falco, M Torchia, R Tutino, G Gulotta
BACKGROUND: Many studies have elaborated different kind of activity indices for Crohn's Disesase (CD) with the endpoint of univocally measure and evaluate the gravity of its lesions and symptoms. AIM: Purpose of this work is to study and define the correlation that runs between the preoperative score obtained at the Crohn's Disease Activity Index, the occurrence of postoperative complications that will require re-intervention and the severity of the postoperative lesions evaluated using the Clavien-Dindo score...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29441677/a-novel-susceptibility-locus-in-mst1-and-gene-gene-interaction-network-for-crohn-s-disease-in-the-chinese-population
#19
William K K Wu, Rui Sun, Tao Zuo, Yuanyuan Tian, Zhirong Zeng, Jeffery Ho, Justin C Y Wu, Francis K L Chan, Matthew T V Chan, Jun Yu, Joseph J Y Sung, Sunny H Wong, Maggie H Wang, Siew C Ng
The incidence of Crohn's disease is increasing in many Asian countries, but considerable differences in genetic susceptibility have been reported between Western and Asian populations. This study aimed to fine-map 23 previously reported Crohn's disease genes and identify their interactions in the Chinese population by Illumina-based targeted capture sequencing. Our results showed that the genetic polymorphism A>G at rs144982232 in MST1 showed the most significant association (P = 1.78 × 10-5; odds ratio = 4...
February 14, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29441457/effect-of-vsl-3-probiotic-in-a-patient-with-glycogen-storage-disease-type-ia-and-irritable-bowel-disease-like-disease
#20
Miguel Carnero-Gregorio, Alberto Molares-Vila, Alberte Corbalán-Rivas, Carlos Villaverde-Taboada, Carmen Rodríguez-Cerdeira
Gut Inflammatory bowel disease (IBD) is a group of chronic gastrointestinal disorders characterised by relapsing and remitting inflammation of the gastrointestinal tract. The two most common types of IBDs are ulcerative colitis and Crohn's disease. Patients with glycogen storage disease (GSD) type Ia present with gastrointestinal symptoms such as recurrent abdominal pain, bloating and changes in stool form or frequency, which is clinically difficult to distinguish from IBD. We report the case of a 36-year-old man with GSD type Ia and IBD-like disease...
February 13, 2018: Probiotics and Antimicrobial Proteins
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