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https://www.readbyqxmd.com/read/29781583/altered-white-matter-connectivity-associated-with-visual-hallucinations-following-occipital-stroke
#1
Sara A Rafique, John R Richards, Jennifer K E Steeves
INTRODUCTION: Visual hallucinations that arise following vision loss stem from aberrant functional activity in visual cortices and an imbalance of activity across associated cortical and subcortical networks subsequent to visual pathway damage. We sought to determine if structural changes in white matter connectivity play a role in cases of chronic visual hallucinations associated with visual cortical damage. METHODS: We performed diffusion tensor imaging (DTI) and probabilistic fiber tractography to assess white matter connectivity in a patient suffering from continuous and disruptive phosphene (simple) visual hallucinations for more than 2 years following right occipital stroke...
May 21, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29780940/colored-floaters-as-a-manifestation-of-digoxin-toxicity
#2
Lynn Shi, Linus D Sun, Jeffrey G Odel
Purpose: Since its report in one patient more than 70 years ago, digitalis-induced colored muscae volitantes have not surfaced again in the literature. We report here a case of digoxin induced colored floaters. Observations: An 89-year-old man on 0.25 mg digoxin daily developed visual hallucinations and colored floaters. He had floaters in the past but now they were in various colors including yellow, green, blue and red, though predominantly in yellow. These "weirdly" shaped little particles wiggled around as if in a viscous solution and casted shadows in his vision...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29768295/requirement-for-head-magnetic-resonance-imaging-in-children-who-present-to-the-emergency-department-with-acute-nontraumatic-visual-disturbance
#3
Jeong-Yong Lee, Jung-Heon Kim, Hyung-Rae Cho, Jong-Seung Lee, Jeong-Min Ryu, Mi-Sun Yum, Tae-Sung Ko
OBJECTIVES: This study aimed to investigate the clinical features and head magnetic resonance imaging (MRI) findings in children who presented to the emergency department with acute nontraumatic visual disturbance and to study related clinical factors for discovering positive lesions on head MRI. METHODS: We performed a retrospective study of 1-month to 15-year-old children who underwent head MRI as an evaluation for acute nontraumatic visual disturbance as a chief complaint in our pediatric emergency department between March 2010 and March 2015...
May 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29744073/complex-visual-hallucinatory-experience-in-an-elderly-blind-woman-with-glaucoma-revisiting-charles-bonnet-syndrome
#4
Azan A Nyundo, Innocent R Mwombeki
For fear of being ridiculed, individuals with visual hallucinations hide their experiences and thus remain unrecognized and miss treatment. An elderly blind woman secondary to glaucoma experienced visual hallucinations accompanied by gross behavior disturbances. She improved with sodium valproate after haloperidol failed and remained relatively improved upon 3 months follow-up.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29742332/clinical-features-of-auditory-hallucinations-in-patients-with-dementia-with-lewy-bodies-a-soundtrack-of-visual-hallucinations
#5
Naoko Tsunoda, Mamoru Hashimoto, Tomohisa Ishikawa, Ryuji Fukuhara, Seiji Yuki, Hibiki Tanaka, Yutaka Hatada, Yusuke Miyagawa, Manabu Ikeda
OBJECTIVE: Auditory hallucinations are an important symptom for diagnosing dementia with Lewy bodies (DLB), yet they have received less attention than visual hallucinations. We investigated the clinical features of auditory hallucinations and the possible mechanisms by which they arise in patients with DLB. METHODS: We recruited 124 consecutive patients with probable DLB (diagnosis based on the DLB International Workshop 2005 criteria; study period: June 2007-January 2015) from the dementia referral center of Kumamoto University Hospital...
May 8, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29734943/low-mood-visual-hallucinations-and-falls-heralding-the-onset-of-rapidly-progressive-probable-sporadic-creutzfeldt-jakob-disease-in-a-73-year-old-a-case-report
#6
Daniel Martin Klotz, Rose Sarah Penfold
BACKGROUND: Creutzfeldt-Jakob disease is a rare and rapidly fatal neurodegenerative disease. Since clinicians may see only very few cases during their professional career, it is important to be familiar with the clinical presentation and progression, to perform appropriate investigations, and allow for quick diagnosis. CASE PRESENTATION: A 73-year-old British Caucasian woman presented with acute confusion of 2 weeks' duration on a background of low mood following a recent bereavement...
May 8, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29723870/functional-disconnectivity-during-inter-task-resting-state-in-dementia-with-lewy-bodies
#7
Eléna Chabran, Daniel Roquet, Daniel Gounot, Marion Sourty, Jean-Paul Armspach, Frédéric Blanc
AIMS: Limited research has been done on the functional connectivity in visuoperceptual regions in dementia with Lewy bodies (DLB) patients. This study aimed to investigate the functional connectivity differences between a task condition and an inter-task resting state condition within a visuoperceptual paradigm, in DLB patients compared with Alzheimer disease (AD) patients and healthy elderly control subjects. METHODS: Twenty-six DLB, 29 AD, and 22 healthy subjects underwent a detailed clinical and neuropsychological examination along with a functional MRI during the different conditions of a visuoperceptual paradigm...
May 3, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29709939/a-case-of-fatal-familial-insomnia-initially-developing-parkinsonism-mimicking-dementia-with-lewy-bodies
#8
Takuya Fukuoka, Yoshihiko Nakazato, Masaomi Yamamoto, Akifumi Miyake, Takashi Mitsufuji, Toshimasa Yamamoto
We report a rare case of fatal familial insomnia in a 58-year-old man who initially developed parkinsonism, secondary dementia, and visual hallucinations that were suspected to be due to dementia with Lewy bodies. We evaluated the function of the striatum via dopamine transporter SPECT using 123 I-ioflupane and found marked presynaptic dopamine dysfunction in the bilateral striatum. This is the first reported case in which the initial symptom of fatal familial insomnia was parkinsonism and in which the dopamine transporter function was evaluated by DAT SPECT...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29707400/-capgras-delusions-involving-belongings-not-people-and-evolving-visual-hallucinations-associated-with-occipital-lobe-seizures
#9
Brandon Lilly, Erika Maynard, Kelly Melvin, Suzanne Holroyd
Capgras syndrome is characterized by the delusional belief that a familiar person has been replaced by a visually similar imposter or replica. Rarely, the delusional focus may be objects rather than people. Numerous etiologies have been described for Capgras to include seizures. Similarly, visual hallucinations, both simple and complex, can occur secondary to seizure activity. We present, to our knowledge, the first reported case of visual hallucinations and Capgras delusions for objects that developed secondary to new onset occipital lobe epilepsy...
2018: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29692973/visual-hallucinations-a-novel-complication-after-hemispherectomy
#10
Jonas Vanags, Monisha Sachdev, Gerald Grant, Mohamad A Mikati
Two patients at our center experienced florid visual hallucinations following hemispherectomy. The first patient had drug-resistant left hemispheric focal seizures at 20 months of age from a previous stroke. Following functional hemispherectomy at age 3, he experienced frightening hallucinations 1 month post-operatively lasting 3.5 months. Our second patient underwent subtotal hemispherectomy at age 6 for drug-resistant focal seizures from right hemispheric cortical dysplasia. Eighteen months later he developed scary visual hallucinations during which he would shout and throw things...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29683518/the-function-and-failure-of-sensory-predictions
#11
REVIEW
Sonia Bansal, Judith M Ford, Miriam Spering
Humans and other primates are equipped with neural mechanisms that allow them to automatically make predictions about future events, facilitating processing of expected sensations and actions. Prediction-driven control and monitoring of perceptual and motor acts are vital to normal cognitive functioning. This review provides an overview of corollary discharge mechanisms involved in predictions across sensory modalities and discusses consequences of predictive coding for cognition and behavior. Converging evidence now links impairments in corollary discharge mechanisms to neuropsychiatric symptoms such as hallucinations and delusions...
April 23, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29682608/-hallucinations-following-acute-cannabis-dosing-a-case-report-and-comparison-to-other-hallucinogenic-drugs
#12
Frederick S Barrett, Nicolas J Schlienz, Natalie Lembeck, Muhammad Waqas, Ryan Vandrey
Introduction: Cannabis has been historically classified as a hallucinogen. However, subjective cannabis effects do not typically include hallucinogen-like effects. Empirical reports of hallucinogen-like effects produced by cannabis in controlled settings, particularly among healthy research volunteers, are rare and have mostly occurred after administration of purified Δ-9 tetrahydrocannabinol (THC) rather than whole plant cannabis. Methods: The case of a healthy 30-year-old male who experienced auditory and visual hallucinations in a controlled laboratory study after inhaling vaporized cannabis that contained 25 mg THC (case dose) is presented...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29662465/the-length-of-snca-rep1-microsatellite-may-influence-cognitive-evolution-in-parkinson-s-disease
#13
Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Donata Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Giacomo P Comi, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi
Background: Alpha-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial Parkinson's disease (PD). A previous study showed that a variant of the alpha-synuclein gene ( SNCA ), namely the 263 bp allele of Rep1 was associated with faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the influence of the Rep1 variants on disease progression in PD patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29653315/eeg-based-neurophysiological-indicators-of-hallucinations-in-alzheimer-s-disease-comparison-with-dementia-with-lewy-bodies
#14
Meenakshi Dauwan, Mascha M J Linszen, Afina W Lemstra, Philip Scheltens, Cornelis J Stam, Iris E Sommer
We studied neurophysiological indicators of hallucinations in Alzheimer's disease patients with hallucinations (ADhall+), and compared them with nonhallucinating AD (ADhall-) and dementia with Lewy bodies (DLBhall+) patients. Thirty-six matched ADhall+ and 108 ADhall- and 29 DLBhall+ patients were selected from the Amsterdam Dementia Cohort. Electroencephalography (EEG) spectral and functional connectivity (FC) analyses (phase lag index) were performed. Quantitative and visual EEG measures were combined in a random forest algorithm to determine which EEG-based variable(s) play a role in hallucinations...
March 19, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29623723/macular-toxicity-and-blind-spot-enlargement-during-a-treatment-by-voriconazole-a-case-report
#15
Anaïs Mounier, Emilie Agard, Ikrame Douma, Hussam El Chehab, Anne L Vie, Jean M Dot, Corinne Dot
PURPOSE: To report a case of macular toxicity and blind spot enlargement during voriconazole treatment. METHODS: This is a case report. RESULTS: We describe a 77-year-old man treated by voriconazole for pulmonary aspergillosis, who complained of visual disorders such as dyschromatopsia and visual hallucinations 3 days after voriconazole initiation. Initial ophthalmological examination found no loss of visual acuity. The anterior and posterior segments presented no anomalies...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29609711/melatonin-responsive-complex-nocturnal-visual-hallucinations
#16
Liudmila Lysenko, Sushanth Bhat
Complex nocturnal visual hallucinations are vivid, dramatic, intricate visual hallucinations occurring during sleep onset or awakenings at night, generally lasting for a few minutes at most and disappearing with increased levels of light. They may occur in a number of neurological conditions, as well as in normal individuals. The optimal treatment for this condition remains unclear. We describe three patients with complex nocturnal visual hallucinations in whom melatonin brought about a dramatic improvement in symptoms...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29593637/structural-and-functional-brain-patterns-of-non-motor-syndromes-in-parkinson-s-disease
#17
REVIEW
Tino Prell
Parkinson's disease (PD) is a common, progressive and multisystem neurodegenerative disorder characterized by motor and non-motor symptoms. Advanced magnetic resonance imaging, positron emission tomography, and functional magnetic resonance imaging can render the view toward understanding the neural basis of these non-motor syndromes, as they help to understand the underlying pathophysiological abnormalities. This review provides an up-to-date description of structural and functional brain alterations in patients with PD with cognitive deficits, visual hallucinations, fatigue, impulsive behavior disorders, sleep disorders, and pain...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29593580/self-reported-visual-perceptual-abnormalities-are-strongly-associated-with-core-clinical-features-in-psychotic-disorders
#18
Brian P Keane, Lisa N Cruz, Danielle Paterno, Steven M Silverstein
Background: Past studies using the Bonn Scale for the Assessment of Basic Symptoms (hereafter, Bonn Scale) have shown that self-reported perceptual/cognitive disturbances reveal which persons have or will soon develop schizophrenia. Here, we focused specifically on the clinical value of self-reported visual perceptual abnormalities (VPAs) since they are underexplored and have been associated with suicidal ideation, negative symptoms, and objective visual dysfunction. Method: Using the 17 Bonn Scale vision items, we cross-sectionally investigated lifetime occurrence of VPAs in 21 first-episode psychosis and 22 chronic schizophrenia/schizoaffective disorder (SZ/SA) patients...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29593537/acute-pharmacological-effects-of-2c-b-in-humans-an-observational-study
#19
Esther Papaseit, Magí Farré, Clara Pérez-Mañá, Marta Torrens, Mireia Ventura, Mitona Pujadas, Rafael de la Torre, Débora González
2,5-dimethoxy-4-bromophenethylamine (2C-B) is a psychedelic phenylethylamine derivative, structurally similar to mescaline. It is a serotonin 5-hydroxytryptamine-2A (5-HT2A ), 5-hydroxytryptamine-2B (5-HT2B ), and 5-hydroxytryptamine-2C (5-HT2C ) receptor partial agonist used recreationally as a new psychoactive substance. It has been reported that 2C-B induces mild psychedelic effects, although its acute pharmacological effects and pharmacokinetics have not yet been fully studied in humans. An observational study was conducted to assess the acute subjective and physiological effects, as well as pharmacokinetics of 2C-B...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29593414/a-low-dose-of-risperidone-resolved-charles-bonnet-syndrome-after-an-unsuccessful-trial-of-quetiapine-a-case-report
#20
Sultan H Alamri
Charles Bonnet syndrome (CBS) is a diagnosis of exclusion. Typical affected patients have impaired visual acuity, vivid recurring visual hallucinations, and no cognitive impairment. Vision loss is most commonly due to macular degeneration, although many other causes exist. Here, we report a case of an 87-year-old woman with CBS and discuss the diagnosis and treatment.
2018: Neuropsychiatric Disease and Treatment
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