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https://www.readbyqxmd.com/read/29762168/multimorbidity-age-related-comorbidities-and-mortality-association-of-activation-senescence-and-inflammation-markers-in-hiv-adults
#1
Pierre Duffau, Alexandra Ozanne, Fabrice Bonnet, Estibaliz Lazaro, Charles Cazanave, Patrick Blanco, Etienne Rivière, Arnaud Desclaux, Caroline Hyernard, Noemie Gensous, I Pellegrin, L Wittkop
BACKGROUND: The widespread introduction of combination antiretroviral therapy (cART) has increased survival of HIV+ patients. However, the prevalence of age-related comorbidities remains higher than that of the general population, suggesting that individuals with HIV suffer from accelerated aging. Immune activation, -senescence and inflammation could play an important role in this process. METHODS: The CIADIS (Chronic Immune Activation anD Senescence) sub-study analyzed biomarkers of activation, differentiation, and senescence of T-cells in a cellular-CIADIS weighted score, while biomarkers of inflammation were analyzed in a soluble-CIADIS weighted score using principal component analysis...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29746512/visual-acuity-and-contrast-sensitivity-are-two-important-factors-affecting-vision-related-quality-of-life-in-advanced-age-related-macular-degeneration
#2
Miin Roh, Alexandra Selivanova, Hyun Joon Shin, Joan W Miller, Mary Lou Jackson
PURPOSE: Vision loss from age-related macular degeneration (AMD) has a profound effect on vision-related quality of life (VRQoL). The pupose of this study is to identify clinical factors associated with VRQoL using the Rasch- calibrated NEI VFQ-25 scales in bilateral advanced AMD patients. METHODS: We retrospectively reviewed 47 patients (mean age 83.2 years) with bilateral advanced AMD. Clinical assessment included age, gender, type of AMD, high contrast visual acuity (VA), history of medical conditions, contrast sensitivity (CS), central visual field loss, report of Charles Bonnet Syndrome, current treatment for AMD and Rasch-calibrated NEI VFQ-25 visual function and socioemotional function scales...
2018: PloS One
https://www.readbyqxmd.com/read/29744073/complex-visual-hallucinatory-experience-in-an-elderly-blind-woman-with-glaucoma-revisiting-charles-bonnet-syndrome
#3
Azan A Nyundo, Innocent R Mwombeki
For fear of being ridiculed, individuals with visual hallucinations hide their experiences and thus remain unrecognized and miss treatment. An elderly blind woman secondary to glaucoma experienced visual hallucinations accompanied by gross behavior disturbances. She improved with sodium valproate after haloperidol failed and remained relatively improved upon 3 months follow-up.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29718199/boutiques-a-flexible-framework-to-integrate-command-line-applications-in-computing-platforms
#4
Tristan Glatard, Gregory Kiar, Tristan Aumentado-Armstrong, Natacha Beck, Pierre Bellec, Rémi Bernard, Axel Bonnet, Shawn T Brown, Sorina Camarasu-Pop, Frédéric Cervenansky, Samir Das, Rafael Ferreira da Silva, Guillaume Flandin, Pascal Girard, Krzysztof J Gorgolewski, Charles R G Guttmann, Valérie Hayot-Sasson, Pierre-Olivier Quirion, Pierre Rioux, Marc-Étienne Rousseau, Alan C Evans
We present Boutiques, a system to automatically publish, integrate and execute command-line applications across computational platforms. Boutiques applications are installed through software containers described in a rich and flexible JSON language. A set of core tools facilitate the construction, validation, import, execution, and publishing of applications. Boutiques is currently supported by several distinct virtual research platforms, and it has been used to describe dozens of applications in the neuroinformatics domain...
March 23, 2018: GigaScience
https://www.readbyqxmd.com/read/29593414/a-low-dose-of-risperidone-resolved-charles-bonnet-syndrome-after-an-unsuccessful-trial-of-quetiapine-a-case-report
#5
Sultan H Alamri
Charles Bonnet syndrome (CBS) is a diagnosis of exclusion. Typical affected patients have impaired visual acuity, vivid recurring visual hallucinations, and no cognitive impairment. Vision loss is most commonly due to macular degeneration, although many other causes exist. Here, we report a case of an 87-year-old woman with CBS and discuss the diagnosis and treatment.
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29560008/closed-eye-visualizations-in-the-setting-of-hyponatremia
#6
Travis Peck, Christopher Mercogliano, Eugene York
Purpose: To report a case of closed-eye visualizations and to clarify the different types of hallucinations and their etiologies. Methods: Retrospective case report of a patient with closed-eye visualizations secondary to hyponatremia. Clinical findings, physical exam, laboratory assessment, treatment, and disease course from the patient's hospitalization were used in creating this report. Follow-up data after discharge were also obtained. Results: Closed-eye visualizations were diagnosed as secondary to hyponatremia, as they did not occur with the eyes open, and potential alternate causes were excluded...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29471318/family-physician-awareness-of-charles-bonnet-syndrome
#7
Keith D Gordon, Tina Felfeli
Background: Charles Bonnet syndrome is characterized by formed visual hallucinations in individuals with vision loss. It is reported that one in five older adults with vision loss suffer from Charles Bonnet syndrome and the suspected lack of awareness amongst family physicians may lead to misdiagnosis and inappropriate treatment. Objective: To assess Canadian family physicians' awareness of Charles Bonnet syndrome. Methods: We conducted a national perception and practices survey of family physicians across Canada to assess (i) the level of awareness of Charles Bonnet syndrome amongst family physicians; (ii) the frequency of family physicians' encounters with patients with visual hallucinations and (iii) management strategies and referral patterns for patients with Charles Bonnet syndrome presenting to family physicians...
February 17, 2018: Family Practice
https://www.readbyqxmd.com/read/29449406/complete-genome-sequence-of-mycobacterium-sp-strain-4858
#8
Amar Bouam, Anthony Levasseur, Maryline Bonnet, Laurence Borand, Charles Van Goethem, Michel Drancourt, Sylvain Godreuil
Mycobacterium sp. strain 4858 is a nontuberculous mycobacterium isolated from sputum in a Cambodian patient with a pulmonary infection. We report the first complete 5.6-Mbp-long genome sequence of Mycobacterium strain 4858, with 68.24% GC content, carrying 5,255 protein-coding genes, 47 tRNAs, and 3 rRNA genes.
February 15, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29431643/epigenetic-dysregulation-of-the-drp1-binding-partners-mid49-and-mid51-increases-mitotic-mitochondrial-fission-and-promotes-pulmonary-arterial-hypertension-mechanistic-and-therapeutic-implications
#9
Kuang-Hueih Chen, Asish Dasgupta, Jianhui Lin, Francois Potus, Sebastien Bonnet, James Iremonger, Jennifer Fu, Jeffrey Mewburn, Danchen Wu, Kimberly Dunham-Snary, Anne L Theilmann, Zhi-Cheng Jing, Charles Hindmarch, Mark L Ormiston, Allan Lawrie, Stephen L Archer
Background -Mitotic fission is increased in pulmonary arterial hypertension (PAH), a hyperproliferative, apoptosis-resistant disease. The fission mediator, dynamin related protein 1 (Drp1) must complex with adaptor proteins to cause fission. Drp1-induced fission has been therapeutically targeted in experimental PAH. Here we examine the role of two recently discovered, poorly understood, Drp1 adapter proteins, mitochondrial dynamics protein of 49 and 51 kDa (MiD49 and MiD51) in normal vascular cells and explore their dysregulation in PAH...
February 5, 2018: Circulation
https://www.readbyqxmd.com/read/29397881/incidence-predictors-and-impact-on-six-month-mortality-of-three-different-definitions-of-contrast-induced-acute-kidney-injury-after-coronary-angiography
#10
Benoit Guillon, Fiona Ecarnot, Charles Marcucci, Didier Ducloux, Marion Chatot, Marc Badoz, Benjamin Bonnet, Romain Chopard, Pierre Frey, Nicolas Meneveau, François Schiele
We assessed incidence, predictors, and impact on 6-month mortality of contrast-induced acute kidney injury (CI-AKI) after coronary angiography with or without percutaneous coronary intervention in patients with acute coronary syndrome (ACS), according to 3 different CI-AKI definitions. Serum creatinine (sCr) was assessed at baseline and 48 to 72 hours after procedure to classify patients into 3 CI-AKI groups: Group 1: increase in sCR ≥25% over baseline but absolute increase <0.5 mg/dl; Group 2: absolute increase ≥0...
April 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29371369/complete-genome-sequence-of-mycobacterium-sp-strain-3519a
#11
Amar Bouam, Anthony Levasseur, Maryline Bonnet, Laurence Borand, Charles Van Goethem, Michel Drancourt, Sylvain Godreuil
Mycobacterium sp. strain 3519A is a nontuberculous mycobacterium isolated from sputum from a Cambodian patient with a pulmonary infection. We report here the first complete 7.3-Mbp-long genome sequence of Mycobacterium sp. 3519A with 66.35% GC content, encoding 7,029 protein-coding genes, 50 tRNAs, and 5 rRNA genes.
January 25, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29186386/gene-expression-pattern-in-response-to-cholecalciferol-supplementation-highlights-cubilin-as-a-major-protein-of-25-oh-d-uptake-in-adipocytes-and-male-mice-white-adipose-tissue
#12
Lauriane Bonnet, Esma Karkeni, Charlène Couturier, Julien Astier, Julie Dalifard, Catherine Defoort, Ljubica Svilar, Jean-Charles Martin, Franck Tourniaire, Jean-François Landrier
It is well established that the active form of vitamin D (i.e., 1,25-dihydroxyvitamin D [1,25(OH)2D]) regulates the expression of genes involved in its own metabolism and transport in the kidney and possibly in the liver. However, little is known about the transcriptional impact of cholecalciferol supplementation on white adipose tissue (WAT) and adipocytes, which are a major site of vitamin D and 25-hydroxyvitamin D [25(OH)D] storage in the organism. To fill this gap, we investigated the impact of cholecalciferol supplementation in WAT via a panel of genes coding for enzymes and proteins involved in vitamin D metabolism and uptake...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29175359/trial-duration-and-risk-reduction-in-combination-therapy-trials-for-pulmonary-arterial-hypertension-a-systematic-review
#13
Annie C Lajoie, Charles-Antoine Guay, Jean-Christophe Lega, Gabriel Lauzière, Serge Simard, Caroline Lambert, Yves Lacasse, Sebastien Bonnet, Steeve Provencher
BACKGROUND: Relative risk (RR) and number needed-to-treat (NNT) are frequently time-dependant measures. We performed a systematic review and meta-analysis to assess whether trial duration influenced the relative and absolute risk of worsening in randomized controlled trials (RCTs) comparing combination therapy (CT) of pulmonary arterial hypertension (PAH)-specific therapies vs monotherapy (MT). METHODS: We searched MEDLINE, Embase, and the Cochrane Library (January 1990 to September 2016) for RCTs assessing CT compared with MT in PAH...
November 23, 2017: Chest
https://www.readbyqxmd.com/read/29145190/charles-bonnet-syndrome-and-other-hallucinatory-phenomena
#14
François Boller, Daniel S Birnbaum, Nicoletta Caputi
Descriptions of hallucinatory phenomena have figured prominently since the beginning of recorded history. Jean Etienne Esquirol (1772-1840) is usually credited for having introduced the term in 1817, differentiating between hallucinations and illusions. Both are wrong perceptions, but in illusions, an external stimulus is always present whereas hallucinations are perceptions that occur in the absence of corresponding sensory stimuli. They occur in a variety of conditions but more often in the mentally ill, especially in schizophrenia where hallucinations, particularly auditory hallucinations represent for many, such as Henri Ey one of the cardinal features...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29129252/design-for-the-sacubitril-valsartan-lcz696-compared-with-enalapril-study-of-pediatric-patients-with-heart-failure-due-to-systemic-left-ventricle-systolic-dysfunction-panorama-hf-study
#15
RANDOMIZED CONTROLLED TRIAL
Robert Shaddy, Charles Canter, Nancy Halnon, Lazaros Kochilas, Joseph Rossano, Damien Bonnet, Christopher Bush, Ziqiang Zhao, Paul Kantor, Michael Burch, Fabian Chen
BACKGROUND: Sacubitril/valsartan (LCZ696) is an angiotensin receptor neprilysin inhibitor approved for the treatment of adult heart failure (HF); however, the benefit of sacubitril/valsartan in pediatric HF patients is unknown. STUDY DESIGN: This global multi-center study will use an adaptive, seamless two-part design. Part 1 will assess the pharmacokinetics/pharmacodynamics of single ascending doses of sacubitril/valsartan in pediatric (1 month to <18 years) HF patients with systemic left ventricle and reduced left ventricular systolic function stratified into 3 age groups (Group 1: 6 to <18 years; Group 2: 1 to <6 years; Group 3: 1 month to <1 year)...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/28843719/incidence-risk-factors-and-mortality-of-neonatal-and-late-onset-dilated-cardiomyopathy-associated-with-cardiac-neonatal-lupus
#16
Nathalie Morel, Kateri Lévesque, Alice Maltret, Gabriel Baron, Mohamed Hamidou, Pauline Orquevaux, Jean-Charles Piette, François Barriere, Jérôme Le Bidois, Laurent Fermont, Olivier Fain, Arnaud Theulin, François Sassolas, Quentin Hauet, Gaëlle Guettrot-Imbert, Sophie Georgin-Lavialle, Christophe Deligny, Eric Hachulla, Luc Mouthon, Claire Le Jeunne, Philippe Ravaud, Delphine Le Mercier, Bénédicte Romefort, Elisabeth Villain, Damien Bonnet, Nathalie Costedoat-Chalumeau
BACKGROUND: Dilated cardiomyopathy (DCM), a well-known complication of cardiac neonatal lupus, is associated with high mortality rate. Its risk factors remain unclear. METHODS: We analyzed occurrence of postnatal DCM among children with high-degree congenital heart block (CHB) and mothers with anti-SSA and/or anti-SSB antibodies. RESULTS: Among 187 neonates with CHB, 35 (18.8%, one missing data) had DCM and 22 (11.8%) died during a median follow-up of 7years [range: birth-36years]...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28829845/the-charles-bonnet-syndrome-in-patients-with-neovascular-age-related-macular-degeneration-association-with-proton-pump-inhibitors
#17
João Esteves Leandro, João Beato, Ana Catarina Pedrosa, João Pinheiro-Costa, Manuel Falcão, Fernando Falcão-Reis, Ângela M Carneiro
Purpose: We investigate the prevalence of the Charles Bonnet syndrome (CBS) in patients with neovascular age-related macular degeneration (AMD) and analyze the role of oral proton pump inhibitors (PPIs) and other potential risk factors. Methods: A total of 510 consecutive patients with neovascular-AMD followed at a single tertiary center in Portugal were screened for CBS. Using a structured questionnaire, psychiatrically healthy individuals were interviewed systematically and divided into a CBS group and a non-CBS group...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28774226/pseudo-charles-bonnet-syndrome-with-a-frontal-tumor-visual-hallucinations-the-brain-and-the-two-hit-hypothesis
#18
Katherine A Kosman, David A Silbersweig
No abstract text is available yet for this article.
2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28754679/adaptive-from-innate-human-ifn-%C3%AE-cd4-t-cells-can-arise-directly-from-cxcl8-producing-recent-thymic-emigrants-in-babies-and-adults
#19
Abhishek Das, Kevin Rouault-Pierre, Shraddha Kamdar, Iria Gomez-Tourino, Kristie Wood, Ian Donaldson, Charles A Mein, Dominique Bonnet, Adrian C Hayday, Deena L Gibbons
We recently demonstrated that the major effector function of neonatal CD4+ T cells is to produce CXCL8, a prototypic cytokine of innate immune cells. In this article, we show that CXCL8 expression, prior to proliferation, is common in newly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies. This effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describing end-stage differentiation, such cells, whether isolated from neonates or adults, can further differentiate into IFN-γ-producing CD4+ T cells...
September 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28670981/keep-an-eye-out-a-rare-case-of-acute-onset-charles-bonnet-syndrome-after-stanford-type-a-aortic-dissection-repair-surgery
#20
Fabian Cook, Scott Dougherty, Robert Moreton, Maziar Khorsandi
Charles Bonnet Syndrome describes the triad of complex visual hallucinations secondary to ophthalmic pathology in psychologically normal people. We present a rare case of acute-onset Charles Bonnet Syndrome following cardiac surgery that resulted in profound loss of visual acuity in both eyes with characteristic visual hallucinations that were initially mistaken for delirium. Computed tomography of the brain revealed bilateral occipital infarcts, providing the substrate for Charles Bonnet Syndrome. A high index of suspicion should be maintained in cognitively intact patients with visual loss who are also experiencing visual hallucinations to ensure prompt diagnosis and management of this often overlooked condition...
May 2017: Scottish Medical Journal
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