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Iontophoresis

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https://www.readbyqxmd.com/read/29613940/enhancing-placebo-effects-in-somatic-symptoms-through-oxytocin
#1
Aleksandrina Skvortsova, Dieuwke S Veldhuijzen, Henriët Van Middendorp, Omer Van den Bergh, Andrea W M Evers
OBJECTIVE: Placebo effects relieve various somatic symptoms but it is unclear how they can be enhanced in order to maximize positive treatment outcomes. Oxytocin administration may potentially enhance placebo effects but few studies have been performed with conflicting findings. The study aim was to investigate the influence of positive verbal suggestions and oxytocin on treatment expectations and placebo effects for pain and itch. METHODS: 108 Female participants were allocated to one of four groups: 1) oxytocin with positive verbal suggestions, 2) placebo with positive verbal suggestions, 3) oxytocin without suggestions, and 4) placebo without suggestions...
March 7, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29603014/impact-of-formulation-on-the-iontophoretic-delivery-of-the-folfirinox-regimen-for-the-treatment-of-pancreatic-cancer
#2
James D Byrne, Mohammad R N Jajja, Adrian T O'Neill, Allison N Schorzman, Amanda W Keeler, J Christopher Luft, William C Zamboni, Joseph M DeSimone, Jen Jen Yeh
PURPOSE: Effective treatment of patients with locally advanced pancreatic cancer is a significant unmet clinical need. One major hurdle that exists is inadequate drug delivery due to the desmoplastic stroma and poor vascularization that is characteristic of pancreatic cancer. The local iontophoretic delivery of chemotherapies provides a novel way of improving treatment. With the growing practice of highly toxic combination therapies in the treatment of pancreatic cancer, the use of iontophoresis for local delivery can potentiate the anti-cancer effects of these therapies while sparing unwanted toxicity...
March 30, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29580829/sweat-test-for-cystic-fibrosis-wearable-sweat-sensor-vs-standard-laboratory-test
#3
Dong-Hoon Choi, Abigail Thaxton, In Cheol Jeong, Kain Kim, Patrick R Sosnay, Garry R Cutting, Peter C Searson
BACKGROUND: Sweat chloride testing for diagnosis of cystic fibrosis (CF) involves sweat induction, collection and handling, and measurement in an analytical lab. We have developed a wearable sensor with an integrated salt bridge for real-time measurement of sweat chloride concentration. Here, in a proof-of-concept study, we compare the performance of the sensor to current clinical practice in CF patients and healthy subjects. METHOD: Sweat was induced on both forearms of 10 individuals with CF and 10 healthy subjects using pilocarpine iontophoresis...
March 23, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29573391/interventional-management-of-hyperhidrosis-in-secondary-care-a-systematic-review
#4
REVIEW
R Wade, A Llewellyn, J Jones-Diette, K Wright, S Rice, A M Layton, N J Levell, D Craig, N Woolacott
BACKGROUND: Hyperhidrosis is uncontrollable excessive sweating, which occurs at rest, regardless of temperature. The symptoms of hyperhidrosis can significantly affect quality of life. OBJECTIVES: To undertake a systematic review of the clinical effectiveness and safety of treatments available in secondary care for the management of primary hyperhidrosis. METHODS: Fifteen databases (including trial registers) were searched to July 2016 to identify studies of secondary care treatments for primary hyperhidrosis...
March 24, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29552273/are-natural-ingredients-effective-in-the-management-of-hyperpigmentation-a-systematic-review
#5
REVIEW
Jasmine C Hollinger, Kunal Angra, Rebat M Halder
BACKGROUND: Hyperpigmentation disorders are commonly encountered in dermatology clinics. Botanical and natural ingredients have gained popularity as alternative depigmenting products. OBJECTIVE: We sought to review clinical studies evaluating the use of different natural products in treating hyperpigmentation so clinicians are better equipped to educate their patients. Specific ingredients reviewed include azelaic acid, aloesin, mulberry, licorice extracts, lignin peroxidase, kojic acid, niacinamide, ellagic acid, arbutin, green tea, turmeric, soy, and ascorbic acid...
February 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29547935/effects-of-riot-control-training-on-systemic-microvascular-reactivity-and-capillary-density
#6
Flavio Pereira, Roger de Moraes, Diogo Van Bavel, Andrea De Lorenzo, Eduardo Tibirica
Introduction: The main aim of the present study is to evaluate the effects of strenuous exercise, related to special military training for riot control, on systemic microvascular endothelial function and skin capillary density. Materials and Methods: Endothelium-dependent microvascular reactivity was evaluated in the forearm skin of healthy military trainees (age 23.4 ± 2.3 yr; n = 15) using laser speckle contrast imaging coupled with cutaneous acetylcholine (ACh) iontophoresis and post-occlusive reactive hyperemia (PORH)...
March 14, 2018: Military Medicine
https://www.readbyqxmd.com/read/29505807/ocular-drug-delivery-targeted-by-iontophoresis-in-the-suprachoroidal-space-using-a-microneedle
#7
Jae Hwan Jung, Bryce Chiang, Hans E Grossniklaus, Mark R Prausnitz
Treatment of many posterior-segment ocular indications would benefit from improved targeting of drug delivery to the back of the eye. Here, we propose the use of iontophoresis to direct delivery of negatively charged nanoparticles through the suprachoroidal space (SCS) toward the posterior pole of the eye. Injection of nanoparticles into the SCS of the rabbit eye ex vivo without iontophoresis led to a nanoparticle distribution mostly localized at the site of injection near the limbus and <15% of nanoparticles delivered to the most posterior region of SCS (>9 mm from the limbus)...
March 2, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29501536/evaluation-of-microvascular-endothelial-function-and-capillary-density-in-patients-with-infective-endocarditis-using-laser-speckle-contrast-imaging-and-video-capillaroscopy
#8
Amanda Barcelos, Eduardo Tibirica, Cristiane Lamas
OBJECTIVE: To evaluate the systemic microcirculation of patients with infective endocarditis (IE). METHODS: This is a comparative study of patients with definite IE by the modified Duke criteria admitted to our center for treatment. A reference group of sex- and age-matched healthy volunteers was included. Microvascular flow was evaluated in the forearm using a laser speckle contrast imaging system, for noninvasive measurement of cutaneous microvascular perfusion, in combination with skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to test microvascular reactivity...
February 28, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29497609/heat-a-highly-efficient-skin-enhancer-for-transdermal-drug-delivery
#9
REVIEW
Sabine Szunerits, Rabah Boukherroub
Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDSs), which use the skin as the main route of drug delivery, are very appealing...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29484614/influence-of-a-combination-of-chemical-enhancers-and-iontophoresis-on-in-vitro-transungual-permeation-of-nystatin
#10
Daniela Monti, Emanuele Egiziano, Susi Burgalassi, Silvia Tampucci, Eleonora Terreni, Serena Tivegna, Patrizia Chetoni
To promote transungual permeation of nystatin (NYST), molecule with high molecular weight, no water-soluble, amphoteric by iontophoresis. The synergic effect of the combination of cetylpyridinium chloride, CPC, or polyoxyethylene (20) sorbitan monooleate, TW80, and iontophoresis was investigated. In vitro permeation experiments were carried out through bovine hoof slices using vertical diffusion cells. A low current density (0.2 mA/cm2 ) was applied by introducing Ag/AgCl electrodes in the donor (anode) and receptor (cathode) chambers...
February 26, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29477356/simultaneous-controlled-iontophoretic-delivery-of-pramipexole-and-rasagiline-in-vitro-and-in-vivo-transdermal-polypharmacy-to-treat-parkinson-s-disease
#11
Dhaval R Kalaria, Mayank Singhal, Vandana Patravale, Virginia Merino, Yogeshvar N Kalia
Effective treatment of Parkinson's disease (PD) involves administration of therapeutic agents with complementary mechanisms of action in order to replenish, sustain or substitute endogenous dopamine. The objective of this study was to investigate anodal co-iontophoresis of pramipexole (PRAM; dopamine agonist) and rasagiline (RAS; MAO-B inhibitor) in vitro and in vivo. Passive permeation of PRAM and RAS (20 mM each) across porcine skin after 6 h was 15.7±1.9 and 16.0±2.9 µg/cm2 , respectively. Co-iontophoresis at 0...
February 22, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29452929/the-short-term-effectiveness-of-low-level-laser-phonophoresis-and-iontophoresis-in-patients-with-lateral-epicondylosis
#12
Seda Baktir, Arzu Razak Ozdincler, Ebru Kaya Mutlu, Kerem Bilsel
STUDY DESIGN: Randomized parallel group trial. INTRODUCTION: Various treatment options for lateral epicondylosis have been reported in the literature. PURPOSE OF STUDY: We aimed to compare the effectiveness of low-level laser therapy (LLLT), phonophoresis, and iontophoresis in terms of pain, function, and grip strength. METHODS: This study that comprised 37 patients with lateral epicondylosis was planned as a prospective randomized parallel group trial...
February 13, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29430629/recent-advances-and-development-in-epidermal-and-dermal-drug-deposition-enhancement-technology
#13
Babar Iqbal, Javed Ali, Sanjula Baboota
Skin is the largest and easily accessible organ of the body. Increases in incidences of dermatological disorders, demand for drug targeting, and patient compliance have increased the popularity of topical drug delivery amongst the people. However, drug delivery across the skin is still a challenge for researchers because permeation of maximum drugs is hindered by the upper layer of the epidermis (stratum corneum). Several approaches like use of chemical permeation enhancers and physical methods such as sonophoresis, iontophoresis, electroporation, microneedles, etc...
February 12, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29425769/combined-use-of-nanocarriers-and-physical-methods-for-percutaneous-penetration-enhancement
#14
Nina Dragicevic, Howard Maibach
Dermal and transdermal drug delivery (due to its non-invasiveness, avoidance of the first-pass metabolism, controlling the rate of drug input over a prolonged time, etc.) have gained significant acceptance. Several methods are employed to overcome the permeability barrier of the skin, improving drug penetration into/through skin. Among chemical penetration enhancement methods, nanocarriers have been extensively studied. When applied alone, nanocarriers mostly deliver drugs to skin and can be used to treat skin diseases...
February 6, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29423944/impact-of-mon2-monocyte-platelet-aggregates-in-humancoronary-artery-disease
#15
Richard A Brown, Gregory Y H Lip, Chetan Varma, Eduard Shantsila
INTRODUCTION: Monocyte-platelet aggregates (MPAs) form when Mon1, Mon2 or Mon3 monocyte subsets adhere to platelets. They are pathophysiologically linked to coronary artery disease (CAD). However, their individual roles in the occurrence of diffuse CAD remain unknown. METHODS: Peripheral blood from 50 patients with diffuse CAD, 40 patients with focal CAD and 50 age-matched patients with normal coronary arteries was analysed by flow cytometry to quantify MPAs associated with individual monocyte subsets...
February 9, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29378433/passive-delivery-of-protein-drugs-through-transdermal-route
#16
Bivek Chaulagain, Ankit Jain, Ankita Tiwari, Amit Verma, Sanjay K Jain
Skin is the largest external organ in the human body but its use for therapeutic purposes has been minimal. Stratum corneum residing on the uppermost layer of the skin provides a tough barrier to transport the drugs across the skin. Very small group of drugs sharing Lipinski properties, i.e. drugs having molecular weight not larger than 500 Da, having high lipophilicity and optimum polarity are fortunate enough to be used on skin therapeutics. But, at a time where modern therapeutics is slowly shifting from use of small molecular drugs towards the use of macromolecular therapeutic agents such as peptides, proteins and nucleotides in origin, skin therapeutics need to be evolved accordingly to cater the delivery of these agents...
January 29, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29355580/sitting-time-is-negatively-related-to-microvascular-endothelium-dependent-function-in-rheumatoid-arthritis
#17
Sally A M Fenton, Aamer Sandoo, George S Metsios, Joan L Duda, George D Kitas, Jet J C S Veldhuijzen van Zanten
BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function...
May 2018: Microvascular Research
https://www.readbyqxmd.com/read/29352759/regional-myocardial-function-abnormalities-are-associated-with-macro-and-microcirculation-dysfunction-in-the-metabolic-syndrome-the-resolve-study
#18
Philippe Obert, Guillaume Walther, Frédéric Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix, Agnes Vinet
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eighty-eight MetS individuals and 44 age- and gender-matched healthy controls were enrolled. LV global longitudinal strain (GLS) was measured using Vector Velocity Imaging...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29340522/penile-microvascular-endothelial-function-in-hypertensive-patients-effects-of-acute-type-5-phosphodiesterase-inhibition
#19
V Verri, A A Brandão, E Tibirica
The primary aim of this study was to evaluate penile endothelial microvascular function in patients with primary arterial hypertension and age-matched normotensive subjects using laser speckle contrast imaging (LSCI). Additionally, we analyzed the acute penile microvascular effects induced by oral phosphodiesterase type 5 inhibitor (sildenafil; SIL) administration. Endothelium-dependent microvascular reactivity was evaluated in the penises and forearms of hypertensive patients (aged 58.8±6.6 years, n=34) and age-matched healthy volunteers (n=33) at rest and 60 min following oral SIL (100 mg) administration...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29338981/reproducibility-and-agreement-of-different-non-invasive-methods-of-endothelial-function-assessment
#20
Khatera Ibrahimi, Young De Graaf, Richard Draijer, A H Jan Danser, Antoinette Maassen VanDenBrink, Anton H van den Meiracker
Flow-mediated dilatation (FMD) is an established, but investigator-demanding method, used to non-invasively determine nitric oxide (NO)-dependent endothelial function in humans. Local thermal hyperemia (LTH) or post-occlusive reactive hyperemia (PORH) of the skin measured with a laser Doppler flow imager may be a less demanding alternative of FMD. We investigated the reproducibility of the different measures of vascular function, their interrelationship and the NO-dependency of LTH. Measurements were performed twice in 27 healthy men (8 smokers), one week apart...
May 2018: Microvascular Research
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