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https://www.readbyqxmd.com/read/28220555/population-pharmacokinetic-characterization-of-bay-81-8973-a-full-length-recombinant-factor-viii-lessons-learned-importance-of-including-samples-with-factor-viii-levels-below-the-quantitation-limit
#1
D Garmann, S McLeay, A Shah, P Vis, M Maas Enriquez, B A Ploeger
INTRODUCTION: The pharmacokinetics (PK), safety and efficacy of BAY 81-8973, a full-length, unmodified, recombinant human factor VIII (FVIII), were evaluated in the LEOPOLD trials. AIM: The aim of this study was to develop a population PK model based on pooled data from the LEOPOLD trials and to investigate the importance of including samples with FVIII levels below the limit of quantitation (BLQ) to estimate half-life. METHODS: The analysis included 1535 PK observations (measured by the chromogenic assay) from 183 male patients with haemophilia A aged 1-61 years from the 3 LEOPOLD trials...
February 20, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28219732/all-trans-retinal-levels-and-formation-of-lipofuscin-precursors-after-bleaching-in-rod-photoreceptors-from-wild-type-and-abca4-mice
#2
Leopold Adler, Chunhe Chen, Yiannis Koutalos
The accumulation of lipofuscin in the cells of the retinal pigment epithelium (RPE) is thought to play an important role in the development and progression of degenerative diseases of the retina. The bulk of RPE lipofuscin originates in reactions of the rhodopsin chromophore, retinal, with components of the photoreceptor outer segment. The 11-cis retinal isomer is generated in the RPE and supplied to rod photoreceptor outer segments where it is incorporated as the chromophore of rhodopsin. It is photoisomerized during light detection to all-trans and subsequently released by photoactivated rhodopsin as all-trans retinal, which is removed through reduction to all-trans retinol in a reaction requiring metabolic input in the form of NADPH...
February 17, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28218698/genetic-assessment-of-african-swine-fever-isolates-involved-in-outbreaks-in-the-democratic-republic-of-congo-between-2005-and-2012-reveals-co-circulation-of-p72-genotypes-i-ix-and-xiv-including-19-variants
#3
Leopold K Mulumba-Mfumu, Jenna E Achenbach, Matthew R Mauldin, Linda K Dixon, Curé Georges Tshilenge, Etienne Thiry, Noelia Moreno, Esther Blanco, Claude Saegerman, Charles E Lamien, Adama Diallo
African swine fever (ASF) is a devastating disease of domestic pigs. It is a socioeconomically important disease, initially described from Kenya, but subsequently reported in most Sub-Saharan countries. ASF spread to Europe, South America and the Caribbean through multiple introductions which were initially eradicated-except for Sardinia-followed by re‑introduction into Europe in 2007. In this study of ASF within the Democratic Republic of the Congo, 62 domestic pig samples, collected between 2005-2012, were examined for viral DNA and sequencing at multiple loci: C-terminus of the B646L gene (p72 protein), central hypervariable region (CVR) of the B602L gene, and the E183L gene (p54 protein)...
February 18, 2017: Viruses
https://www.readbyqxmd.com/read/28218343/immediate-affective-responses-of-gait-training-in-neurological-rehabilitation-a-randomized-crossover-trial
#4
Martin Niedermeier, Larissa Ledochowski, Andreas Mayr, Leopold Saltuari, Martin Kopp
OBJECTIVE: To examine the immediate effects of physical therapy and robotic-assisted gait training on affective responses of gait training in neurological rehabilitation. DESIGN: Randomized crossover trial with blinded observers. PATIENTS: Sixteen patients with neurological disorders (stroke, traumatic brain injury, spinal cord injury, multiple sclerosis). METHODS: All patients underwent 2 single treatment sessions: physical therapy and robotic-assisted gait training...
February 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28196953/prevalence-and-patterns-of-congenital-heart-diseases-in-africa-a-systematic-review-and-meta-analysis-protocol
#5
Aurel T Tankeu, Jean Joel R Bigna, Jobert Richie N Nansseu, Leopold Ndemnge Aminde, Celestin Danwang, Mazou N Temgoua, Jean Jacques N Noubiap
INTRODUCTION: Congenital heart diseases (CHD) are common causes of cardiovascular morbidity and mortality among young children and adolescents living in Africa. Accurate epidemiological data are needed in order to evaluate and improve preventive strategies. This review aims to determine the prevalence of CHD and their main patterns in Africa. METHODS AND ANALYSIS: This systematic review and meta-analysis will include cross-sectional, case-control and cohort studies of populations residing inside African countries, which have reported the prevalence of CHD, confirmed by an echocardiographic examination and/or describing different patterns of these abnormalities in Africa...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28196526/the-genetic-architecture-of-low-temperature-adaptation-in-the-wine-yeast-saccharomyces-cerevisiae
#6
Estéfani García-Ríos, Miguel Morard, Leopold Parts, Gianni Liti, José M Guillamón
BACKGROUND: Low-temperature growth and fermentation of wine yeast can enhance wine aroma and make them highly desirable traits for the industry. Elucidating response to cold in Saccharomyces cerevisiae is, therefore, of paramount importance to select or genetically improve new wine strains. As most enological traits of industrial importance in yeasts, adaptation to low temperature is a polygenic trait regulated by many interacting loci. RESULTS: In order to unravel the genetic determinants of low-temperature fermentation, we mapped quantitative trait loci (QTLs) by bulk segregant analyses in the F13 offspring of two Saccharomyces cerevisiae industrial strains with divergent performance at low temperature...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28178944/two-case-reports-of-unexpected-tracheal-agenesis-in-the-neonate-3-c-s-beyond-algorithms-for-difficult-airway-management
#7
Beate Grass, Leopold Simma, Michael Reinehr, Urs Zimmermann, Claudine Gysin, Georg Henze, Vincenzo Cannizzaro
BACKGROUND: Handling neonates with postnatal respiratory failure due to congenital airway malformations implies knowledge about emergency management of unexpected difficult airway. In these stressful situations both technical and communication skills of the caretakers are essential. CASE PRESENTATION: Two cases with prenatally unknown tracheal agenesis are reported. CONCLUSION: In the presented cases, airway malformation and subsequent difficulties upon endotracheal intubation were not adequately communicated between caretakers...
February 8, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28178880/runaway-inequality-leopold-les-2015-runaway-inequality-an-activist-s-guide-to-economic-justice-new-york-ny-labor-institute-press-314-pp-19-95-pbk-isbn-9780692436301
#8
Harris Gruman
No abstract text is available yet for this article.
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28174627/night-syncope-a-case-report
#9
Léopold Loumaye, Dominique Blommaert
"Idiopathic" ventricular fibrillations are rare and are estimated between 5% and 10% of survivors of hospital cardiac arrest, for at least some of them have as origin, a trigger in the Purkinje fibers. Interventional therapy could be an effective, long-lasting solution for these recurrent malignant arrhythmias and should be considered.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28172348/arrest-interrogate-an-interactive-immunoprofiler-for-ig-tr-ngs-data
#10
Vojtech Bystry, Tomas Reigl, Adam Krejci, Martin Demko, Barbora Hanakova, Andrea Grioni, Henrik Knecht, Max Schlitt, Peter Dreger, Leopold Sellner, Dietrich Herrmann, Marine Pingeon, Myriam Boudjoghra, Jos Rijntjes, Christiane Pott, Anton W Langerak, Patricia J T A Groenen, Frederic Davi, Monika Brüggemann, Nikos Darzentas
No abstract text is available yet for this article.
February 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28150302/immunological-consequences-of-strain-variation-within-the-mycobacterium-tuberculosis-complex
#11
Leopold D Tientcheu, Anastasia Koch, Mthawelenga Ndengane, Genevieve Andoseh, Beate Kampmann, Robert J Wilkinson
In 2015 there were an estimated 10.4 million new cases of Tuberculosis (TB) globally, making it one of the leading causes of death due to an infectious disease. TB is caused by members of the Mycobacterium tuberculosis complex (MTBC), with human disease resulting from infection by M. tuberculosis sensu strico and M. africanum. Recent progress in genotyping techniques, in particular the increasing availability of whole genome sequence data, has revealed previously under appreciated levels of genetic diversity within the MTBC...
February 2, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28143983/rim-pathway-mediated-alterations-in-the-fungal-cell-wall-influence-immune-recognition-and-inflammation
#12
Kyla S Ost, Shannon K Esher, Chrissy M Leopold Wager, Louise Walker, Jeanette Wagener, Carol Munro, Floyd L Wormley, J Andrew Alspaugh
: Compared to other fungal pathogens, Cryptococcus neoformans is particularly adept at avoiding detection by innate immune cells. To explore fungal cellular features involved in immune avoidance, we characterized cell surface changes of the C. neoformans rim101Δ mutant, a strain that fails to organize and shield immunogenic epitopes from host detection. These cell surface changes are associated with an exaggerated, detrimental inflammatory response in mouse models of infection. We determined that the disorganized strain rim101Δ cell wall increases macrophage detection in a contact-dependent manner...
January 31, 2017: MBio
https://www.readbyqxmd.com/read/28129507/on-surface-synthesis-and-characterization-of-9-atom-wide-armchair-graphene-nanoribbons
#13
Leopold Talirz, Hajo Söde, Tim Dumslaff, Shiyong Wang, Juan Ramon Sanchez-Valencia, Jia Liu, Prashant Shinde, Carlo A Pignedoli, Liangbo Liang, Vincent Meunier, Nicholas C Plumb, Ming Shi, Xinliang Feng, Akimitsu Narita, Klaus Müllen, Roman Fasel, Pascal Ruffieux
The bottom-up approach to synthesize graphene nanoribbons strives not only to introduce a band gap into the electronic structure of graphene but also to accurately tune its value by designing both the width and edge structure of the ribbons with atomic precision. We report the synthesis of an armchair graphene nanoribbon with a width of nine carbon atoms on Au(111) through surface-assisted aryl-aryl coupling and subsequent cyclodehydrogenation of a properly chosen molecular precursor. By combining high-resolution atomic force microscopy, scanning tunneling microscopy, and Raman spectroscopy, we demonstrate that the atomic structure of the fabricated ribbons is exactly as designed...
February 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28128694/the-rectus-capitis-lateralis-and-the-condylar-triangle-important-landmarks-in-posterior-and-lateral-approaches-to-the-jugular-foramen
#14
Michael A Cohen, Alexander I Evins, Gennaro Lapadula, Leopold Arko, Philip E Stieg, Antonio Bernardo
OBJECTIVE The rectus capitis lateralis (RCL) is a small posterior cervical muscle that originates from the transverse process of C-1 and inserts onto the jugular process of the occipital bone. The authors describe the RCL and its anatomical relationships, and discuss its utility as a surgical landmark for safe exposure of the jugular foramen in extended or combined skull base approaches. In addition, the condylar triangle is defined as a landmark for localizing the vertebral artery (VA) and occipital condyle...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28127947/recommended-approaches-to-the-scientific-evaluation-of-ecotoxicological-hazards-and-risks-of-endocrine-active-substances
#15
Peter Matthiessen, Gerald T Ankley, Ronald C Biever, Poul Bjerregaard, Christopher Borgert, Kristin Brugger, Amy Blankinship, Janice Chambers, Katherine K Coady, Lisa Constantine, Zhichao Dang, Nancy D Denslow, David A Dreier, Steve Dungey, L Earl Gray, Melanie Gross, Patrick D Guiney, Markus Hecker, Henrik Holbech, Taisen Iguchi, Sarah Kadlec, Natalie K Karouna-Renier, Ioanna Katsiadaki, Yukio Kawashima, Werner Kloas, Henry Krueger, Anu Kumar, Laurent Lagadic, Annegaaike Leopold, Steven L Levine, Gerd Maack, Sue Marty, James Meador, Ellen Mihaich, Jenny Odum, Lisa Ortego, Joanne Parrott, Daniel Pickford, Mike Roberts, Christoph Schaefers, Tamar Schwarz, Keith Solomon, Tim Verslycke, Lennart Weltje, James R Wheeler, Mike Williams, Jeffrey C Wolf, Kunihiko Yamazaki
A SETAC Pellston Workshop(®) "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrine-disrupting substance (EDS) under review...
January 27, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28124297/editorial-the-minimum-clinically-important-difference-the-least-we-can-do
#16
EDITORIAL
Seth S Leopold, Raphaël Porcher
No abstract text is available yet for this article.
January 25, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28121924/autoimmune-diseases-and-hiv-infection-a-cross-sectional-study
#17
Emilie Virot, Antoine Duclos, Leopold Adelaide, Patrick Miailhes, Arnaud Hot, Tristan Ferry, Pascal Seve
To describe the clinical manifestations, treatments, prognosis, and prevalence of autoimmune diseases (ADs) in human immunodeficiency virus (HIV)-infected patients.All HIV-infected patients managed in the Infectious Diseases Department of the Lyon University Hospitals, France, between January 2003 and December 2013 and presenting an AD were retrospectively included.Thirty-six ADs were found among 5186 HIV-infected patients which represents a prevalence of 0.69% including immune thrombocytopenic purpura (n = 15), inflammatory myositis (IM) (n = 4), sarcoidosis (n = 4), Guillain-Barré syndrome (GBS) (n = 4), myasthenia gravis (n = 2), Graves' disease (n = 2), and 1 case of each following conditions: systemic lupus erythematosus, rheumatoid arthritis, autoimmune hepatitis, Hashimoto thyroiditis and autoimmune hemolytic anemia...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28118593/human-neurophysiology-sampling-the-perceptual-world
#18
David A Leopold, Brian E Russ
As we move our gaze through a complex scene, the retinal image is constantly shifted and overwritten. A new study using human intracranial recordings offers a fresh perspective on how the brain creates a sense of perceptual continuity through natural visual behavior.
January 23, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28114167/leptin-protects-against-mortality-and-organ-dysfunction-in-a-two-hit-trauma-sepsis-model-and-is-il-6-dependent
#19
Lukas Leopold Negrin, Andreas Jahn, Martijn van Griensven
INTRODUCTION: Leptin is thought to play an important role in the regulation of the immune system. In patients, leptin is inversely proportional to interleukin-6 (IL-6) levels. Thus, the objective of our study was to evaluate a dose-dependent therapeutic impact of leptin with possible IL-6-dependency on immune actions and outcome in a trauma/sepsis model. MATERIALS AND METHODS: Sixty-nine wild-type and 63 IL-6 mice were subdivided into three groups: trauma/sepsis group (first hit: femur fracture and hemorrhage; second hit: cecal ligation and puncture 2 days later), trauma group (first hit and laparotomy), sham group (laparotomy only)...
January 20, 2017: Shock
https://www.readbyqxmd.com/read/28111481/taphonomy-and-palaeoecology-of-late-triassic-carnian-ammonoid-concentrations-from-the-taurus-mountains-turkey
#20
Susanne Mayrhofer, Alexander Lukeneder, Leopold Krystyn
The deposits of the Carnian Kasımlar Formation within the Taurus Platform Units of south-western Turkey represent an important archive of a Late Triassic ecosystem. New palaeontological information was obtained by analysing the Kasimlarceltites mass occurrence, located within the Kasımlar Formation and named after the Lower Carnian (Julian) ammonoid genus Kasimlarceltites. This is the dominant taxon (> 94%) within the mass occurrence: nearly 775 million ammonoids and 50 million gastropods were extrapolated for the whole extension (at least 5 km(2)) of the Kasimlarceltites beds...
January 2017: Lethaia
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