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https://www.readbyqxmd.com/read/28538143/openrbc-a-fast-simulator-of-red-blood-cells-at%C3%A2-protein-resolution
#1
Yu-Hang Tang, Lu Lu, He Li, Constantinos Evangelinos, Leopold Grinberg, Vipin Sachdeva, George Em Karniadakis
We present OpenRBC, a coarse-grained molecular dynamics code, which is capable of performing an unprecedented in silico experiment-simulating an entire mammal red blood cell lipid bilayer and cytoskeleton as modeled by multiple millions of mesoscopic particles-using a single shared memory commodity workstation. To achieve this, we invented an adaptive spatial-searching algorithm to accelerate the computation of short-range pairwise interactions in an extremely sparse three-dimensional space. The algorithm is based on a Voronoi partitioning of the point cloud of coarse-grained particles, and is continuously updated over the course of the simulation...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28537964/the-impact-of-the-affordable-care-act-on-cancer-survivorship
#2
Christine Leopold, Elyse R Park, Larissa Nekhlyudov
In 2010, the Patient Protection and Affordable Care Act (ACA) was implemented with the aim of expanding access to quality, affordable care. In this review, we describe the ACA provisions that are most relevant for cancer survivors, provide available published evidence, and offer insights for future research. We found that provisions focusing on access to preventive care, access to quality and coordinated care, and coverage expansion and increased affordability suggest beneficial effects. However, we identified research gaps specifically addressing the intended and unintended consequences of the ACA on cancer survivorship care...
May 2017: Cancer Journal
https://www.readbyqxmd.com/read/28520430/fluorescence-dynamics-of-a-fret-probe-designed-for-crowding-studies
#3
Megan Currie, Hannah Leopold, Jacob Schwarz, Arnold J Boersma, Erin D Sheets, Ahmed A Heikal
Living cells are crowded with macromolecules and organelles. As a result, there is an urgent need for molecular sensors for quantitative, site-specific assessment of the macromolecular crowding effects on a myriad of biochemical processes towards quantitative cell biology and biophysics. Here we investigate the excited-state dynamics and translational diffusion of a novel FRET sensor (mCerulean-linker-mCitrine) in a buffer (PBS, pH 7.4) at room temperature. Complementary experiments were carried out on free CFP, YFP, and the cleaved FRET probe as controls...
May 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28510624/chromatic-interocular-switch-rivalry
#4
Jens H Christiansen, Anthony D D'Antona, Steven K Shevell
Interocular-switch rivalry (also known as stimulus rivalry) is a kind of binocular rivalry in which two rivalrous images are swapped between the eyes several times a second. The result is stable periods of one image and then the other, with stable intervals that span many eye swaps (Logothetis, Leopold, & Sheinberg, 1996). Previous work used this close kin of binocular rivalry with rivalrous forms. Experiments here test whether chromatic interocular-switch rivalry, in which the swapped stimuli differ in only chromaticity, results in slow alternation between two colors...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28506683/the-caspase-1-inhibitor-card18-is-specifically-expressed-during-late-differentiation-of-keratinocytes-and-its-expression-is-lost-in-lichen-planus
#5
Haihong Qin, Jiang Jin, Heinz Fischer, Michael Mildner, Maria Gschwandtner, Veronika Mlitz, Leopold Eckhart, Erwin Tschachler
BACKGROUND: CARD18 contains a caspase recruitment domain (CARD) via which it binds to caspase-1 and thereby inhibits caspase-1-mediated activation of the pro-inflammatory cytokine interleukin (IL)-1β. OBJECTIVES: To determine the expression profile and the role of CARD18 during differentiation of keratinocytes and to compare the expression of CARD18 in normal skin and in inflammatory skin diseases. METHODS: Human keratinocytes were induced to differentiate in monolayer and in 3D skin equivalent cultures...
May 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28493926/obesity-and-access-to-kidney-transplantation-in-patients-starting-dialysis-a-prospective-cohort-study
#6
Mathilde Lassalle, Léopold K Fezeu, Cécile Couchoud, Thierry Hannedouche, Ziad A Massy, Sébastien Czernichow
BACKGROUND: Obesity has been linked to poor access to medical care. Although scientific evidence suggest that kidney transplantation improves survival and quality of life in obese patients with end-stage renal disease (ESRD), few data exist on the impact of obesity on access to kidney transplantation in this population. OBJECTIVES: We aimed to characterize the relationships between body mass index (BMI) at the start of dialysis, changes in BMI after the start of dialysis, and either access to kidney transplantation or overall mortality in dialysis or transplantation among ESRD patients...
2017: PloS One
https://www.readbyqxmd.com/read/28481933/the-limits-to-growth-energetic-burden-of-the-endogenous-antibiotic-tropodithietic-acid-in-phaeobacter-inhibens-dsm-17395
#7
Sabine Eva Will, Meina Neumann-Schaal, Raymond Leopold Heydorn, Pascal Bartling, Jörn Petersen, Dietmar Schomburg
Phaeobacter inhibens DSM 17395, a model organism for marine Roseobacter group, was studied for its response to its own antimicrobial compound tropodithietic acid (TDA). TDA biosynthesis is encoded on the largest extrachromosomal element of P. inhibens, the 262 kb plasmid, whose curation leads to an increased growth and biomass yield. In this study, the plasmid-cured strain was compared to the wild-type strain and to transposon mutants lacking single genes of the TDA biosynthesis. The data show that the growth inhibition of the wild-type strain can be mainly attributed to the TDA produced by P...
2017: PloS One
https://www.readbyqxmd.com/read/28473196/in-vitro-evaluation-of-the-potential-toxic-effects-of-palladium-nanoparticles-on-fibroblasts-and-lung-epithelial-cells
#8
I Iavicoli, M Farina, L Fontana, D Lucchetti, V Leso, C Fanali, V Cufino, A Boninsegna, K Leopold, R Schindl, D Brucker, A Sgambato
Palladium nanoparticles have been increasingly used in catalytic processes, wastewater treatment, electronics, and biomedicine. However, recent evidence proved that these nanoparticles are able to induce adverse effects both in in vitro and in vivo models. Nevertheless, molecular mechanisms underlying the toxic effects are still poorly understood. Therefore, this study aimed to investigate the potential toxicological mechanisms of palladium nanoparticles assessing their effects on normal diploid rat fibroblast and lung carcinoma human epithelial cell lines...
May 1, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28468289/antiproliferative-and-apoptotic-potential-of-cyanidin-based-anthocyanins-on-melanoma-cells
#9
Dumitriţa Rugină, Daniela Hanganu, Zoriţa Diaconeasa, Flaviu Tăbăran, Cristina Coman, Loredana Leopold, Andrea Bunea, Adela Pintea
Elderberries are known for their high anthocyanins content, which have been shown to possess anti-proliferative and anti-cancer effects. Anthocyanins enriched extract (AEE) was obtained from elderberries and was characterized by LC/DAD/ESI-MS analysis. Five cyanidin-based anthocyanins were identified, among which Cy-3-O-samb was the major compound (51%). The total anthocyanins content of AEE was 495 mg Cy-3-O-samb/100 g FW. AEE inhibited proliferation of metastatic B16-F10 murine melanoma cells, in a concentration-dependent manner, with an IC50 of 264...
April 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28465824/manual-therapy-compared-with-physical-therapy-in-patients-with-non-specific-neck-pain-a-randomized-controlled-trial
#10
Ruud Groeneweg, Luite van Assen, Hans Kropman, Huco Leopold, Jan Mulder, Bouwien C M Smits-Engelsman, Raymond W J G Ostelo, Rob A B Oostendorp, Maurits W van Tulder
BACKGROUND: Manual therapy according to the School of Manual Therapy Utrecht (MTU) is a specific type of passive manual joint mobilization. MTU has not yet been systematically compared to other manual therapies and physical therapy. In this study the effectiveness of MTU is compared to physical therapy, particularly active exercise therapy (PT) in patients with non-specific neck pain. METHODS: Patients neck pain, aged between 18-70 years, were included in a pragmatic randomized controlled trial with a one-year follow-up...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28465797/environmental-impact-assessment-of-gonabad-municipal-waste-landfill-site-using-leopold-matrix
#11
Seyed Ali Sajjadi, Zohreh Aliakbari, Mohammad Matlabi, Hamed Biglari, Seyedeh Samira Rasouli
INTRODUCTION: An environmental impact assessment (EIA) before embarking on any project is a useful tool to reduce the potential effects of each project, including landfill, if possible. The main objective of this study was to assess the environmental impact of the current municipal solid waste disposal site of Gonabad by using the Iranian Leopold matrix method. METHODS: This cross-sectional study was conducted to assess the environmental impacts of a landfill site in Gonabad in 2015 by an Iranian matrix (modified Leopold matrix)...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28464034/tectus-trochus-niloticus-search-for-suitable-habitats-can-cause-equivocal-benefits-of-protection-in-village-based-marine-reserves
#12
Pascal Dumas, Jayven Ham, Rocky Kaku, Andrew William, Jeremie Kaltavara, Sompert Gereva, Marc Léopold
In the Pacific, the protection of coral reef resources is often achieved through the implementation of village-based marine reserves (VBMRs). While substantial fisheries benefits are often reported, results of quantitative approaches are controversial for benthic macroinvertebrates, whose life history traits may cause low congruence with protective measures implemented at non-ecologically relevant scales. This study investigated the structural and behavioral responses of the exploited topshell Tectus niloticus within a very small (0...
2017: PloS One
https://www.readbyqxmd.com/read/28461058/a-population-mri-brain-template-and-analysis-tools-for-the-macaque
#13
REVIEW
Jakob Seidlitz, Caleb Sponheim, Daniel Glen, Frank Q Ye, Kadharbatcha S Saleem, David A Leopold, Leslie Ungerleider, Adam Messinger
The use of standard anatomical templates is common in human neuroimaging, as it facilitates data analysis and comparison across subjects and studies. For non-human primates, previous in vivo templates have lacked sufficient contrast to reliably validate known anatomical brain regions and have not provided tools for automated single-subject processing. Here we present the "National Institute of Mental Health Macaque Template", or NMT for short. The NMT is a high-resolution in vivo MRI template of the average macaque brain generated from 31 subjects, as well as a neuroimaging tool for improved data analysis and visualization...
April 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/28458145/chlorite-reactivity-with-myoglobin-analogy-with-peroxide-and-nitrite-chemistry
#14
Cristina Bischin, Augustin Mot, Andrei Stefancu, Nicolae Leopold, Denisa Hathazi, Grigore Damian, Radu Silaghi-Dumitrescu
Stopped-flow UV-vis data allow for the first time direct spectroscopic detection of a ferryl species during the reaction of met myoglobin (Mb) with chlorite, analogous to what is observed in the reaction with peroxides. Ferryl is also observed in the reaction of oxy Mb+chlorite. A pathway involving Fe-O-O-ClO2 is explored by analogy with the Fe-O-O-NO and Fe-O-O-NO2 previously proposed as intermediates in the reactions of oxy globins with nitric oxide and nitrite, respectively. However, Fe-O-O-ClO2 is not detectable in these stopped-flow experiments and is in fact, unlike its nitrogenous congeners, predicted by density functional theory (DFT) to be impossible for a heme complex...
April 23, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28455728/editorial-getting-the-most-from-what-you-read-in-orthopaedic-journals
#15
EDITORIAL
Seth S Leopold
No abstract text is available yet for this article.
April 28, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28449884/a-rapidly-changing-global-medicines-environment-how-adaptable-are-funding-decision-making-systems
#16
Christine Leopold, Steven G Morgan, Anita K Wagner
BACKGROUND: With the launch of very highly priced therapies and sudden price increases of generics, pressures on health systems have drastically increased. OBJECTIVES: We aimed to elicit opinions of key decision makers responsible for national assessment and funding decisions on their experiences to adapt to these new realities. METHODS/SETTING: Through interviews with decision makers of pharmaceutical assessment and/or funding agencies, we describe the challenges systems are currently facing, systems' responses and systems' characteristics facilitating or hindering responses to changes and overarching topics for the future...
April 10, 2017: Health Policy
https://www.readbyqxmd.com/read/28449641/cell-free-hemoglobin-mediated-oxidative-stress-is-associated-with-acute-kidney-injury-and-renal-replacement-therapy-in-severe-falciparum-malaria-an-observational-study
#17
Katherine Plewes, Hugh W F Kingston, Aniruddha Ghose, Richard J Maude, M Trent Herdman, Stije J Leopold, Haruhiko Ishioka, Md Mahtab Uddin Hasan, Md Shafiul Haider, Shamsul Alam, Kim A Piera, Prakaykaew Charunwatthana, Kamolrat Silamut, Tsin W Yeo, Md Abul Faiz, Sue J Lee, Mavuto Mukaka, Gareth D H Turner, Nicholas M Anstey, L Jackson Roberts, Nicholas J White, Nicholas P J Day, Md Amir Hossain, Arjen M Dondorp
BACKGROUND: Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown. METHODS: As part of a prospective observational study, enrolment plasma cell-free hemoglobin (CFH), lipid peroxidation markers (F2-isoprostanes (F2-IsoPs) and isofurans (IsoFs)), red cell deformability, and serum creatinine were quantified in Bangladeshi patients with severe falciparum malaria (n = 107), uncomplicated malaria (n = 80) and sepsis (n = 28)...
April 27, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28441068/a-controlled-randomized-double-blind-study-to-evaluate-the-safety-and-efficacy-of-chitosan-n-acetylcysteine-for-the-treatment-of-dry-eye-syndrome
#18
Doreen Schmidl, René Werkmeister, Semira Kaya, Angelika Unterhuber, Katarzyna J Witkowska, Renate Baumgartner, Sonja Höller, Maria O'Rourke, Ward Peterson, Annika Wolter, Martin Prinz, Leopold Schmetterer, Gerhard Garhöfer
PURPOSE: This study was designed to evaluate the effect of chitosan-N-acetylcysteine (C-NAC) eye drops on tear film thickness (TFT) in patients with dry eye syndrome (DES). METHODS: This was a controlled, randomized, double-blind clinical investigation with patients assigned to 2 cohorts. In Cohort I, 21 patients were randomized to receive 1 instillation of C-NAC eye drops in 1 eye and placebo (normal saline solution) in the contralateral eye. In Cohort II, 17 patients were randomized to receive C-NAC eye drops once (QD) or twice (BID) daily for 5 days...
April 25, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28438435/postoperative-treatment-of-metacarpal-fractures-classical-physical-therapy-compared-with-a-home-exercise-program
#19
Joachim Gülke, Barbara Leopold, Daniel Grözinger, Björn Drews, Stephan Paschke, Nikolaus J Wachter
STUDY DESIGN: Prospective cohort randomized controlled trial. PURPOSE OF THE STUDY: Is either a home exercise (HE) program or traditional physical therapy (PT) more effective in the postoperative management of metacarpal fractures? METHODS: Sixty patients suffering from nonthumb metacarpal fractures who received mobilization-stable open reduction and internal fixation were included. All patients were prospectively randomized into either the PT group or the HE group...
April 21, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28432160/infective-endocarditis-in-octogenarians
#20
Léopold Oliver, Cécile Lavoute, Roch Giorgi, Erwan Salaun, Sandrine Hubert, Jean-Paul Casalta, Frédérique Gouriet, Sebastien Renard, Ludivine Saby, Jean-Francois Avierinos, Laurie-Anne Maysou, Alberto Riberi, Dominique Grisoli, Anne-Claire Casalta, Frédéric Collart, Didier Raoult, Gilbert Habib
OBJECTIVE: To describe the characteristics of infective endocarditis (IE) in octogenarians and assess their prognosis. METHODS: Patients with definite IE hospitalised at a referral centre between July 2008 and July 2013 were prospectively included. A total of 454 patients were divided into three groups: 230 patients under 65 years old, 173 patients between 65 and 80 years old, and 51 patients over 80 years old. The main end point was 1-year mortality. RESULTS: One-year mortality was higher in the ≥80 years old group (37...
April 21, 2017: Heart: Official Journal of the British Cardiac Society
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