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https://www.readbyqxmd.com/read/29782501/disentangling-the-complexity-of-tropical-small-scale-fisheries-dynamics-using-supervised-self-organizing-maps
#1
Manuel Mendoza-Carranza, Elisabet Ejarque, Leopold A J Nagelkerke
Tropical small-scale fisheries are typical for providing complex multivariate data, due to their diversity in fishing techniques and highly diverse species composition. In this paper we used for the first time a supervised Self-Organizing Map (xyf-SOM), to recognize and understand the internal heterogeneity of a tropical marine small-scale fishery, using as model the fishery fleet of San Pedro port, Tabasco, Mexico. We used multivariate data from commercial logbooks, including the following four factors: fish species (47), gear types (bottom longline, vertical line+shark longline and vertical line), season (cold, warm), and inter-annual variation (2007-2012)...
2018: PloS One
https://www.readbyqxmd.com/read/29780410/quantification-of-upper-limb-motor-recovery-and-eeg-power-changes-after-robot-assisted-bilateral-arm-training-in-chronic-stroke-patients-a-prospective-pilot-study
#2
Marialuisa Gandolfi, Emanuela Formaggio, Christian Geroin, Silvia Francesca Storti, Ilaria Boscolo Galazzo, Marta Bortolami, Leopold Saltuari, Alessandro Picelli, Andreas Waldner, Paolo Manganotti, Nicola Smania
Background: Bilateral arm training (BAT) has shown promise in expediting progress toward upper limb recovery in chronic stroke patients, but its neural correlates are poorly understood. Objective: To evaluate changes in upper limb function and EEG power after a robot-assisted BAT in chronic stroke patients. Methods: In a within-subject design, seven right-handed chronic stroke patients with upper limb paresis received 21 sessions (3 days/week) of the robot-assisted BAT...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29779250/soy-protein-supplement-intake-for-12-months-has-no-effect-on-sexual-maturation-and-may-improve-nutritional-status-in-pre-pubertal-children
#3
Sandra M Duitama, Javier Zurita, Diana Cordoba, Paola Duran, Leopold Ilag, Wilson Mejia
AIM: To evaluate the intake of a soy protein-based supplement (SPS) and its effects on the sexual maturation and nutritional status of prepubertal children who consumed it for a year. METHODS: Healthy children (n = 51) were recruited and randomly assigned to consume the lunch fruit juice with (n = 29) or without (n = 22) addition of 45 g of a commercial soy protein-based supplement (SPS) over 12 months. Nutritional assessment including anthropometry (bodyweight, height, triceps skinfold thickness, mid-upper arm circumference), body mass index (BMI), upper arm muscle area, arm muscle circumference, upper arm area, upper arm fat area data were derived from measures using usual procedures; age and gender-specific percentiles were used as reference...
May 20, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29776183/slowdown-of-surface-diffusion-during-early-stages-of-bacterial-colonization
#4
T Vourc'h, H Peerhossaini, J Léopoldès, A Méjean, F Chauvat, C Cassier-Chauvat
We study the surface diffusion of the model cyanobacterium Synechocystis sp. PCC6803 during the incipient stages of cell contact with a glass surface in the dilute regime. We observe a twitching motility with alternating immobile tumble and mobile run periods, resulting in a normal diffusion described by a continuous-time random walk with a coefficient of diffusion D. Surprisingly, D is found to decrease with time down to a plateau. This is observed only when the cyanobacterial cells are able to produce released extracellular polysaccharides, as shown by a comparative study between the wild-type strain and various polysaccharides-depleted mutants...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29773963/why-local-air-pollution-is-more-than-daily-peaks-modelling-policies-in-a-city-in-order-to-avoid-premature-deaths
#5
Doris A Behrens, Olivia Koland, Ulrike Leopold-Wildburger
We use a predator-prey representation of an urban system to analyse how policy interventions can prevent the adverse effects of air pollution on people's health. The number of residents is treated as prey variable, and particulate matter that consists of particles with a diameter of up to 10 micrometres ( PM10 ) as predator variable. This representation allows integration of population trends and the effects of environmental interventions on the average level of PM10 concentration (which establishes a baseline for the potential health burden for residents)...
2018: Central European Journal of Operations Research
https://www.readbyqxmd.com/read/29764474/acute-blindness-as-a-presenting-sign-of-childhood-endemic-burkitt-s-lymphoma-in-cameroon-a-case-report
#6
Brice N Vofo, Gaelle V F Ngankam, Calypse A Ngwasiri, Jeannine A Atem, Leopold N Aminde
BACKGROUND: Endemic Burkitt's lymphoma is found predominantly in malaria holoendemic zones, typically in the tropical rain forest of Africa. It usually presents as an extra-nodal tumour in children and young adults with predilection for jaws and soft tissues of the abdomen. Clinical features depend on the primary tumour site, extent of the disease and histologic subtype. Acute blindness as a presentation sign is rare. CASE PRESENTATION: A 13 year old African female presented to our facility with a 3 week history of painful abdominal distention, and loss of vision of the left eye...
May 16, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29761017/eleven-years-experience-with-intrathecal-baclofen-complications-risk-factors
#7
Elke Pucks-Faes, Gabriel Hitzenberger, Heinrich Matzak, Elena Fava, Giulio Verrienti, Ilse Laimer, Josef Fritz, Leopold Saltuari
Objective: Treatment with intrathecal baclofen (ITB) is commonly used in patients with severe spasticity. However, complications may occur after implantation of the ITB-device, albeit mainly procedure- and device-related problems. The aim of the study was to assess surgical- as well as catheter- and pump-related complications and define their risk factors. Methods: We retrospectively evaluated all patients with an implanted ITB-device who were treated at the Department of Neurology, Hochzirl Hospital, Zirl, Austria, between 2006 and 2016...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29759541/the-phenotypic-spectrum-of-a-mutation-hotspot-responsible-for-the-short-qt-syndrome
#8
Dan Hu, Yang Li, Jiancheng Zhang, Ryan Pfeiffer, Michael H Gollob, Jeff Healey, Daniel Toshio Harrell, Naomasa Makita, Haruhiko Abe, Yaxun Sun, Jihong Guo, Li Zhang, Ganxin Yan, Douglas Mah, Edward P Walsh, Harris B Leopold, Carla Giustetto, Fiorenzo Gaita, Agnieszka Zienciuk-Krajka, Andrea Mazzanti, Silvia G Priori, Charles Antzelevitch, Hector Barajas-Martinez
OBJECTIVES: This study sought to evaluate the phenotypic and functional expression of an apparent hotspot mutation associated with short QT syndrome (SQTS). BACKGROUND: SQTS is a rare channelopathy associated with a high risk of life-threatening arrhythmias and sudden cardiac death (SCD). METHODS: Probands diagnosed with SQTS and their family members were evaluated clinically and genetically. KCNH2 wild-type (WT) and mutant genes were transiently expressed in HEK293 cells, and currents were recorded using whole-cell patch clamp and action potential (AP) clamp techniques...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29756161/risk-factors-for-failure-of-systemic-to-pulmonary-artery-shunts-in-biventricular-circulation
#9
Keti Vitanova, Cornelius Leopold, Jelena Pabst von Ohain, Cordula Wolf, Elisabeth Beran, Rüdiger Lange, Julie Cleuziou
Systemic-to-pulmonary artery shunt placement is an established palliative procedure for congenital heart disease, but it is associated with high morbidity and mortality. Data of all patients with biventricular circulation who underwent systemic-to-pulmonary artery shunt implantation between 2000 and 2016 were reviewed. Endpoints of the study were shunt failure and shunt-related mortality. Shunt failure was defined as any shunt dysfunction requiring intervention or reoperation. Shunt-related mortality was defined as death due to shunt dysfunction...
May 14, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29742786/-patient-controlled-analgesia-pca-an-overview-about-methods-handling-and-new-modalities
#10
Marie Abrolat, Leopold H J Eberhart, Gerald Kalmus, Tilo Koch, Stefan Nardi-Hiebl
Patient-controlled analgesia (PCA) is one of the well established methods for the treatment of postoperative pain. A cochrane-review concluded that PCA is associated with better postoperative pain ratings and improved patient-satifaction compared to traditional way of administering opioids. Some prerequisites concerning patient selection, education of the patient and the medical staff, and supervision during PCA therapy are mandatory for a safe use of PCA. Current PCA modalities (intravenous and epidural routes of application) are expanded by newer, less invasive routes of drug administration, e...
April 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29720906/development-of-preclinical-models-to-understand-and-treat-colorectal-cancer
#11
REVIEW
Judith S Sebolt-Leopold
The establishment and validation of preclinical models that faithfully recapitulate the pathogenesis and treatment response of human colorectal cancer (CRC) is critical to expedient therapeutic advances in the clinical management of this disease. Integral to the application of precision medicine for patients diagnosed with metastatic CRC is the need to understand the molecular determinants of response for a given therapy. Preclinical models of CRC have proven invaluable in answering many of our basic questions relating to the molecular aberrations that drive colorectal tumor progression...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29718412/t7-rna-polymerase-non-specifically-transcribes-and-induces-disassembly-of-dna-nanostructures
#12
Samuel W Schaffter, Leopold N Green, Joanna Schneider, Hari K K Subramanian, Rebecca Schulman, Elisa Franco
The use of proteins that bind and catalyze reactions with DNA alongside DNA nanostructures has broadened the functionality of DNA devices. DNA binding proteins have been used to specifically pattern and tune structural properties of DNA nanostructures and polymerases have been employed to directly and indirectly drive structural changes in DNA structures and devices. Despite these advances, undesired and poorly understood interactions between DNA nanostructures and proteins that bind DNA continue to negatively affect the performance and stability of DNA devices used in conjunction with enzymes...
April 30, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29716939/oncogenic-mutants-of-mek1-a-trilogy-unfolds
#13
Joel D Maust, Christopher E Whitehead, Judith S Sebolt-Leopold
<b/> It has generally been assumed that MEK mutants function similarly to one another and respond in the same manner to targeted drugs. Gao and colleagues challenge this assumption and report that MEK1 mutants fall into three unique phenotypic classes with respect to RAF dependency. A new class of MEK1 mutants is shown here to be RAF-independent, resistant to allosteric MEK inhibitors, and yet sensitive to treatment with a new ATP-competitive MEK inhibitor. Cancer Discov; 8(5); 534-6. ©2018 AACR See related article by Gao et al...
May 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29709420/outcome-of-patients-with-cardiac-amyloidosis-admitted-to-an-intensive-care-unit-for-acute-heart-failure
#14
Thomas d'Humières, Damien Fard, Thibaud Damy, Francois Roubille, Arnaud Galat, Huy-Long Doan, Leopold Oliver, Jean-Luc Dubois-Randé, Pierre Squara, Pascal Lim, Julien Ternacle
BACKGROUND: The outcome of cardiac amyloidosis (CA) has been reported mainly in stable populations; limited data are available in patients referred for acute heart failure (AHF) to an intensive cardiac care unit (ICCU). AIMS: To address the characteristics and outcomes of patients with confirmed CA admitted to an ICCU for AHF and then to identify the predictors of evolution to cardiogenic shock. METHODS: All patients with CA referred to an ICCU for AHF between 2009 and 2015 were included...
April 27, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29707238/open-surgery-for-haemorrhoids-in-persons-with-spinal-cord-injury
#15
J G Previnaire, N De Bont, H Bordi, N Senal, P E Mortier
Study design: Pilot retrospective study on the outcome of open surgery for grade III and IV haemorrhoids in patients with SCI. Objective: Haemorrhoids and anal fissures are common in patients with spinal cord injury (SCI). Grade I to III haemorrhoids are usually managed medically or by surgical ligation. Grade III and IV haemorrhoids are treated with surgical haemorrhoidectomy in the general population, but not in patients with SCI, most probably due to fear of complications...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29704307/mecp2-variation-in-rett-syndrome-an-overview-of-current-coverage-of-genetic-and-phenotype-data-within-existing-databases
#16
Gillian S Townend, Friederike Ehrhart, Henk J van Kranen, Mark Wilkinson, Annika Jacobsen, Marco Roos, Egon L Willighagen, David van Enckevort, Chris T Evelo, Leopold M G Curfs
Rett syndrome (RTT) is a monogenic rare disorder that causes severe neurological problems. In most cases it results from a loss of function mutation in the gene encoding methyl-CPG-binding protein 2 (MECP2). Currently, about 900 unique MECP2 variations (benign and pathogenic) have been identified and it is suspected that the different mutations contribute to different levels of disease severity. For researchers and clinicians, it is important that genotype-phenotype information is available to identify disease-causing mutations for diagnosis, to aid in clinical management of the disorder, and to provide counselling for parents...
April 27, 2018: Human Mutation
https://www.readbyqxmd.com/read/29700074/emerging-role-of-precision-medicine-in-cardiovascular-disease
#17
REVIEW
Jane A Leopold, Joseph Loscalzo
Precision medicine is an integrative approach to cardiovascular disease prevention and treatment that considers an individual's genetics, lifestyle, and exposures as determinants of their cardiovascular health and disease phenotypes. This focus overcomes the limitations of reductionism in medicine, which presumes that all patients with the same signs of disease share a common pathophenotype and, therefore, should be treated similarly. Precision medicine incorporates standard clinical and health record data with advanced panomics (ie, transcriptomics, epigenomics, proteomics, metabolomics, and microbiomics) for deep phenotyping...
April 27, 2018: Circulation Research
https://www.readbyqxmd.com/read/29698307/editor-s-spotlight-take-5-body-mass-index-is-associated-with-all-cause-mortality-after-tha-and-tka
#18
Seth S Leopold
No abstract text is available yet for this article.
April 23, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29694181/ionization-induced-self-channeling-of-an-ultrahigh-power-subnanosecond-microwave-beam-in-a-neutral-gas
#19
G Shafir, Ya E Krasik, Y P Bliokh, D Levko, Y Cao, J G Leopold, R Gad, V Bernshtam, A Fisher
Ionization-induced self-channeling of a ≤500  MW, 9.6 GHz, <1  ns microwave beam injected into air at ∼4.5×10^{3}  Pa or He at ∼10^{3}  Pa is experimentally demonstrated for the first time. The plasma, generated by the impact ionization of the gas driven by the microwave beam, has a radial density distribution reducing towards the beam axis, where the microwave field is highest, because the ionization rate is a decreasing function of the microwave amplitude. This forms a plasma channel which prevents the divergence of the microwave beam...
March 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29691720/invariance-of-adhd-symptoms-across-sex-and-age-a-latent-analysis-of-adhd-and-impairment-ratings-from-early-childhood-into-adolescence
#20
Daniel R Leopold, Micaela E Christopher, Richard K Olson, Stephen A Petrill, Erik G Willcutt
A population-based longitudinal sample of 489 twin pairs was assessed at six time points over ten years to examine the measurement invariance and stability of attention-deficit/hyperactivity disorder (ADHD) symptoms, as well as the developmental relations between inattention (IN), hyperactivity-impulsivity (HI), and multiple aspects of functional impairment. Parent ratings of ADHD symptoms and functional impairment were obtained in preschool and after the completion of kindergarten, first, second, fourth, and ninth grades...
April 25, 2018: Journal of Abnormal Child Psychology
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