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https://www.readbyqxmd.com/read/29138092/abnormal-cortical-neuroplasticity-induced-by-paired-associative-stimulation-after-traumatic-spinal-cord-injury-a-preliminary-study
#1
Viviana Versace, Patrick B Langthaler, Yvonne Höller, Vanessa N Frey, Francesco Brigo, Luca Sebastianelli, Leopold Saltuari, Raffaele Nardone
We aimed at assessing in this pilot study whether patients with spinal cord injury (SCI) show alterations of sensorimotor plasticity within the primary motor cortex (M1). Since learning in human M1 occurs through LTP-like mechanisms, we employed the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP-like effects in M1, in subjects with chronic SCI. We found that PAS protocol significantly increased corticospinal excitability as long as 30minutes in healthy subjects and in SCI patients with good motor recovery, while it was followed by a non-significant increase of MEP amplitude in the SCI patients with poor functional recovery...
November 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29129015/melanoma-inhibition-by-anthocyanins-is-associated-with-the-reduction-of-oxidative-stress-biomarkers-and-changes-in-mitochondrial-membrane-potential
#2
Zoriţa Diaconeasa, Huseyin Ayvaz, Dumitriţa Ruginǎ, Loredana Leopold, Andreea Stǎnilǎ, Carmen Socaciu, Flaviu Tăbăran, Lavinia Luput, Diana Carla Mada, Adela Pintea, Andrew Jefferson
Anthocyanins are water soluble pigments which have been proved to exhibit health benefits. Several studies have investigated their effects on several types of cancer, but little attention has been given to melanoma. The phytochemical content of nine different berry samples was assessed by liquid chromatography followed by electrospray ionization mass spectrometry (LC-ESI(+)-MS). Twenty-six anthocyanins were identified, after a previous C18 Sep-pak clean-up procedure. Chokeberry and red grape anthocyanins rich extracts (C-ARE and RG-ARE) were selected to be tested on normal and melanoma cell lines, due to their different chemical pattern...
November 11, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29125616/acute-type-a-aortic-dissection-involving-the-iliac-and-left-renal-arteries-misdiagnosed-as-myocardial-infarction
#3
Paul Nkemtendong Tolefac, Anastase Dzudie, Sidick Mouliom, Leopold Aminde, Romuald Hentchoya, Martin H Abanda, Charles Mve Mvondo, Vanina D Wanko, Henry N Luma
Acute aortic dissection is the most frequent and deadly presentation of acute aortic syndromes. Its incidence is estimated at three to four cases per 100 000 persons per year. Its clinical presentation may be misleading, with misdiagnosis ranging between 14.1 and 38% in many series. A late diagnosis or absence of early and appropriate management is associated with mortality rates as high as 50 and 80% by the third day and second week, respectively, especially in proximal lesions. We report on the case of a 53-year-old man who presented with type A aortic dissection, misdiagnosed as acute myocardial infarction, who later died on day 12 of hospitalisation...
November 3, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29122942/a-special-report-on-the-nhlbi-initiative-to-study-cellular-and-molecular-mechanisms-of-arterial-stiffness-and-its-association-with-hypertension
#4
Young S Oh, Dan E Berkowitz, Richard A Cohen, C Alberto Figueroa, David G Harrison, Jay D Humphrey, Douglas F Larson, Jane A Leopold, Robert P Mecham, Nelson Ruiz-Opazo, Lakshmi Santhanam, Francesca Seta, John Y J Shyy, Zhongjie Sun, Philip S Tsao, Jessica E Wagenseil, Zorina S Galis
No abstract text is available yet for this article.
November 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29113004/direct-acting-antiviral-agents-in-the-treatment-of-chronic-hepatitis-c-real-life-experience-from-an-academic-centre-and-two-specialized-clinical-practices
#5
Manuel Jonathan Groß, Georg Härter, Johanna Backhus, Eugen Zizer, Thomas Seufferlein, Leopold Ludwig, Nektarios Dikopoulos
The introduction of the new direct antiviral agents has revolutionized the therapy of chronic hepatitis C. Today we are able to cure the vast majority of our patients with an 8- to 12-week therapy course of an antiviral combination therapy with an excellent safety profile. Real-life data are very important to further develop our experience with the new therapeutics and help us to improve the care of our patients in our everyday clinical practice.In our study, we present the retrospective analysis of a representative German cohort of 344 patients with chronic hepatitis C treated with the new direct antiviral agents...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29099599/observation-of-two-conformers-of-acrylic-sulfuric-anhydride-by-microwave-spectroscopy
#6
C J Smith, Anna K Huff, Rebecca B Mackenzie, Kenneth R Leopold
The rotational spectrum of acrylic sulfuric anhydride (CH2═CHCOOSO2OH, AcrSA) has been observed using pulsed-nozzle Fourier transform microwave spectroscopy. The species was produced from the reaction between acrylic acid and sulfur trioxide in a supersonic jet. Spectroscopic constants are reported for both the s-cis- and s-trans-AcrSA conformers of the parent and monodeuterated (OD) isotopologues. Geometries were optimized for both conformers using M06-2X/6-311++G(3df,3pd) methods. Single-point energy calculations at the M06-2X geometries were calculated using the CCSD(T)/complete basis set method with double and triple extrapolation [CBS(D-T)]...
November 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29089981/how-the-brain-can-rewire-itself-after-an-injury-the-lesson-from-hemispherectomy
#7
Luca Sebastianelli, Leopold Saltuari, Raffaele Nardone
No abstract text is available yet for this article.
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29089568/alzheimer-s-disease-and-cigarette-smoke-components-effects-of-nicotine-pahs-and-cd-ii-cr-iii-pb-ii-pb-iv-ions-on-amyloid-%C3%AE-peptide-aggregation
#8
Cecilia Wallin, Sabrina B Sholts, Nicklas Österlund, Jinghui Luo, Jüri Jarvet, Per M Roos, Leopold Ilag, Astrid Gräslund, Sebastian K T S Wärmländer
Cigarette smoking is a significant risk factor for Alzheimer's disease (AD), which is associated with extracellular brain deposits of amyloid plaques containing aggregated amyloid-β (Aβ) peptides. Aβ aggregation occurs via multiple pathways that can be influenced by various compounds. Here, we used AFM imaging and NMR, fluorescence, and mass spectrometry to monitor in vitro how Aβ aggregation is affected by the cigarette-related compounds nicotine, polycyclic aromatic hydrocarbons (PAHs) with one to five aromatic rings, and the metal ions Cd(II), Cr(III), Pb(II), and Pb(IV)...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29079753/norrin-protects-optic-nerve-axons-from-degeneration-in-a-mouse-model-of-glaucoma
#9
Stephanie A Leopold, Ludwig F Zeilbeck, Gregor Weber, Roswitha Seitz, Michael R Bösl, Herbert Jägle, Rudolf Fuchshofer, Ernst R Tamm, Andreas Ohlmann
Norrin is a secreted signaling molecule activating the Wnt/β-catenin pathway. Since Norrin protects retinal neurons from experimental acute injury, we were interested to learn if Norrin attenuates chronic damage of retinal ganglion cells (RGC) and their axons in a mouse model of glaucoma. Transgenic mice overexpressing Norrin in the retina (Pax6-Norrin) were generated and crossed with DBA/2J mice with hereditary glaucoma and optic nerve axonal degeneration. One-year old DBA/2J/Pax6-Norrin animals had significantly more surviving optic nerve axons than their DBA/2J littermates...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29078940/is-there-a-place-for-outpatient-preinduction-cervical-ripening
#10
REVIEW
Beth Leopold, Anthony Sciscione
Induction of labor continues to be one of the most commonly performed tasks in obstetrics. If trials like the National Institute of Child Health and Human Development's ARRIVE trial show that delivery for all women at 39 weeks provides a significant advantage in pregnancy outcomes, the number of women who require induction of labor will considerably increase. Strategies to improve patient/family satisfaction, decrease resource allocation and costs, and assure safety are paramount. Although there are many potential candidates, it seems that outpatient preinduction cervical ripening with the Foley catheter meets these criteria in a properly selected group of low-risk women...
December 2017: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29074534/pvdomics-a-multi-center-study-to-improve-understanding-of-pulmonary-vascular-disease-through-phenomics
#11
Anna R Hemnes, Gerald J Beck, John H Newman, Aiden Abidov, Micheala A Aldred, John Barnard, Erika Berman Rosenzweig, Barry A Borlaug, Wendy K Chung, Suzy A A Comhair, Serpil C Erzurum, Robert P Frantz, Michael P Gray, Gabriele Grunig, Paul M Hassoun, Nicholas S Hill, Evelyn M Horn, Bo Hu, Jason K Lempel, Bradley A Maron, Stephen C Mathai, Mitchell A Olman, Franz P Rischard, David M Systrom, W H Wilson Tang, Aaron B Waxman, Lei Xiao, Jason X-J Yuan, Jane A Leopold
No abstract text is available yet for this article.
October 27, 2017: Circulation Research
https://www.readbyqxmd.com/read/29073928/safety-of-tubal-ligation-by-minilaparotomy-provided-by-clinical-officers-versus-assistant-medical-officers-study-protocol-for-a-noninferiority-randomized-controlled-trial-in-tanzanian-women
#12
Mark A Barone, Zuhura Mbuguni, Japhet Ominde Achola, Carmela Cordero, Joseph Kanama, Projestine S Muganyizi, Jamilla Mwanga, Caitlin Shannon, Leopold Tibyehabwa
BACKGROUND: Female sterilization by tubal ligation is a safe, extremely effective, and permanent way to limit childbearing. It is the most popular modern contraceptive method worldwide. The simplest way to provide tubal ligation is by a procedure called minilaparotomy, generally performed with the client under local anesthesia with systemic sedation and analgesia. In Tanzania, unmet need for family planning is high and has declined little in the past decade. Access to tubal ligation is limited throughout the country, in large part because of a lack of trained providers...
October 26, 2017: Trials
https://www.readbyqxmd.com/read/29057844/functional-characterization-of-rare-rab12-variants-and-their-role-in-musician-s-and-other-dystonias
#13
REVIEW
Eva Hebert, Friederike Borngräber, Alexander Schmidt, Aleksandar Rakovic, Ingrid Brænne, Anne Weissbach, Jennie Hampf, Eva-Juliane Vollstedt, Leopold Größer, Susen Schaake, Michaela Müller, Humera Manzoor, Hans-Christian Jabusch, Daniel Alvarez-Fischer, Meike Kasten, Vladimir S Kostic, Thomas Gasser, Kirsten E Zeuner, Han-Joon Kim, Beomseok Jeon, Peter Bauer, Eckart Altenmüller, Christine Klein, Katja Lohmann
Mutations in RAB (member of the Ras superfamily) genes are increasingly recognized as cause of a variety of disorders including neurological conditions. While musician's dystonia (MD) and writer's dystonia (WD) are task-specific movement disorders, other dystonias persistently affect postures as in cervical dystonia. Little is known about the underlying etiology. Next-generation sequencing revealed a rare missense variant (c.586A>G; p.Ile196Val) in RAB12 in two of three MD/WD families. Next, we tested 916 additional dystonia patients; 512 Parkinson's disease patients; and 461 healthy controls for RAB12 variants and identified 10 additional carriers of rare missense changes among dystonia patients (1...
October 18, 2017: Genes
https://www.readbyqxmd.com/read/29056403/a-non-destructive-method-for-quality-control-of-the-pellet-distribution-within-a-mups-tablet-by-terahertz-pulsed-imaging
#14
Anna Novikova, Daniel Markl, J Axel Zeitler, Thomas Rades, Claudia S Leopold
Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform...
October 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29049294/impact-of-dynamic-changes-of-elevated-bilirubin-on-survival-in-patients-on-veno-arterial-extracorporeal-life-support-for-acute-circulatory-failure
#15
Miriam Freundt, Dirk Lunz, Alois Philipp, Bernd Panholzer, Matthias Lubnow, Christine Friedrich, Leopold Rupprecht, Stephan Hirt, Assad Haneya
AIMS: Veno-arterial extracorporeal life support (ECLS) is an established method to stabilize acute circulatory failure. Parameters and data on when to ideally wean circulatory support are limited. Bilirubin is a marker of end-organ damage. Therefore, the purpose of this large study was to evaluate the impact of dynamic changes of elevated bilirubin levels on survival in patients on ECLS. METHODS AND RESULTS: We reviewed 502 consecutive cases of ECLS from 2007 to 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29041999/electrodiagnostic-and-nerve-ultrasonographic-features-in-upper-limb-spasticity-an-observational-study
#16
A Picelli, S Tamburin, G Berto, E Chemello, Marialuisa Gandolfi, Leopold Saltuari, Andreas Waldner, Nicola Smania
To better understand the effects of spasticity on peripheral nerves, we evaluated the electrodiagnostic and nerve ultrasonographic features of the median and ulnar nerves in adults with upper limb spasticity. Twenty chronic stroke patients with spastic hemiparesis underwent nerve conduction study and nerve ultrasonography of the median and ulnar nerves at both upper limbs. Affected versus unaffected upper limb comparisons showed significant differences in the median and ulnar nerve distal motor latencies, compound muscle action potentials and F-wave minimal latencies...
July 2017: Functional Neurology
https://www.readbyqxmd.com/read/29041142/integrated-waveguide-pin-photodiodes-exploiting-lateral-si-ge-si-heterojunction
#17
Léopold Virot, Daniel Benedikovic, Bertrand Szelag, Carlos Alonso-Ramos, Bayram Karakus, Jean-Michel Hartmann, Xavier Le Roux, Paul Crozat, Eric Cassan, Delphine Marris-Morini, Charles Baudot, Frédéric Boeuf, Jean-Marc Fédéli, Christophe Kopp, Laurent Vivien
Germanium photodetectors are considered to be mature components in the silicon photonics device library. They are critical for applications in sensing, communications, or optical interconnects. In this work, we report on design, fabrication, and experimental demonstration of an integrated waveguide PIN photodiode architecture that calls upon lateral double Silicon/Germanium/Silicon (Si/Ge/Si) heterojunctions. This photodiode configuration takes advantage of the compatibility with contact process steps of silicon modulators, yielding reduced fabrication complexity for transmitters and offering high-performance optical characteristics, viable for high-speed and efficient operation near 1...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29040093/queen-victoria-s-youngest-two-sons-princes-arthur-and-leopold
#18
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Anesthesiology
https://www.readbyqxmd.com/read/29029414/targeting-adam17-inhibits-human-colorectal-adenocarcinoma-progression-and-tumor-initiating-cell-frequency
#19
Joseph Dosch, Elizabeth Ziemke, Shanshan Wan, Kathryn Luker, Theodore Welling, Karin Hardiman, Eric Fearon, Suneetha Thomas, Matthew Flynn, Jonathan Rios-Doria, Robert Hollingsworth, Ronald Herbst, Elaine Hurt, Judith Sebolt-Leopold
ADAM17 (a disintegrin and metalloproteinase 17)/TACE (TNFα converting enzyme) has emerged as a potential therapeutic target in colorectal cancer (CRC) and other cancers, due in part to its role in regulating various tumor cell surface proteins and growth factors and cytokines in the tumor microenvironment. The emergence of MEDI3622, a highly potent and specific antibody-based ADAM17 inhibitor, has allowed testing of the concept that targeting ADAM17 may be an important new therapeutic approach for CRC patients...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28994179/lysosome-targeting-amplifiers-of-reactive-oxygen-species-as-anticancer-prodrugs
#20
Steffen Daum, M S Viktor Reshetnikov, Miroslav Sisa, Tetyana Dumych, Maxim D Lootsik, Rostyslav Bilyy, Evgenia Bila, Christina Janko, Christoph Alexiou, Martin Herrmann, Leopold Sellner, Andriy Mokhir
Cancer cells produce elevated levels of reactive oxygen species, which has been used to design cancer specific prodrugs. Their activation relies on at least a bimolecular process, in which a prodrug reacts with ROS. However, at low micromolar concentrations of the prodrugs and ROS, the activation is usually inefficient. Herein, we propose and validate a potentially general approach for solving this intrinsic problem of ROS-dependent prodrugs. In particular, known prodrug 4-(N-ferrocenyl-N-benzylaminocarbonyloxymethyl)phenylboronic acid pinacol ester was converted into its lysosome-specific analogue...
October 9, 2017: Angewandte Chemie
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