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butylated hydroxytoluene

Babar Hassan, Sohail Ahmed, Grant Kirker, Mark E Mankowski, Muhammad Misbah-Ul-Haq
Heterotermes indicola (Wasmann) (Blattodea: Rhinotermitidae) is a species of subterranean termite that is a destructive pest of wood and wood products in Pakistan. This study evaluated the antioxidant and antienzyme potential of heartwood extractives against H. indicola. Heartwood extractives of four durable wood species, Tectona grandis (L.f), Dalbergia sissoo (Roxb.), Cedrus deodara (Roxb.), and Pinus roxburghii (Sarg.) were removed from wood shavings via soxhlet extraction with an ethanol:toluene solvent system...
March 8, 2018: Environmental Entomology
L Rubio, L A Sarabia, M C Ortiz
This paper presents the simultaneous determination of a UV stabilizer (benzophenone (BP)) together with four plasticizers (butylated hydroxytoluene (BHT), diisobutyl phthalate (DiBP), bis(2-ethylhexyl) adipate (DEHA) and diisononyl phthalate (DiNP)) in Tenax by gas chromatography/mass spectrometry and PARAFAC, using DiBP-d4 as internal standard. Regulation (EU) No. 10/2011 establishes Tenax as food simulant E for testing specific migration from plastics into dry foodstuffs. This simulant must be cleaned before its use to eliminate impurities...
May 15, 2018: Talanta
Rafael Torres-Martínez, Yolanda Magdalena García-Rodríguez, Patricia Ríos-Chávez, Alfredo Saavedra-Molina, Joel Edmundo López-Meza, Alejandra Ochoa-Zarzosa, Rafael Salgado Garciglia
Background: The aim of this study was to investigate the in vitro antioxidant activity of Satureja macrostema (Moc. and Sessé ex Benth.) Briq. (Lamiaceae) essential oil, a Mexican medicinal plant known as nurite. Materials and Methods: Fresh aerial parts of S. macrostema plants cultivated in greenhouse for 3 months were subjected to hydrodistillation in a Clevenger apparatus to obtain essential oil. Volatile compounds were identified by gas chromatography (GC) and GC/mass spectrometry...
January 2018: Pharmacognosy Magazine
Renu Pandey, Christopher L Riley, Edward M Mills, Stefano Tiziani
Coenzyme Q (CoQ) is a redox active molecule that plays a fundamental role in mitochondrial energy generation and functions as a potent endogenous antioxidant. Redox ratio of CoQ has been suggested as a good marker of mitochondrial dysfunction and oxidative stress. Nevertheless, simultaneous measurement of redox states of CoQ is challenging owing to its hydrophobicity and instability of the reduced form. In order to improve the analytical methodology, paying special attention to this instability, we developed a highly sensitive and selective high-resolution/accurate-mass (HR/AM) UHPLC-MS/MS method for the rapid determination of redox states of CoQ9 and CoQ10 by ultra-performance liquid chromatography-hybrid quadrupole-Orbitrap mass spectrometry...
June 29, 2018: Analytica Chimica Acta
Xueqin Wang, Huahua Yu, Ronge Xing, Xiaolin Chen, Song Liu, Pengcheng Li
Mackerel ( Pneumatophorus japonicus ) viscera contain large amount of protein. We used five proteases to hydrolyze the viscera, and the hydrolysate treated by neutrase exhibited the highest nitrogen recovery (NR). Then we optimized the preparation conditions for mackerel viscera hydrolysate (MVH) by response surface methodology and investigated the antioxidant activity of MVH. The optimal conditions were as follows: enzyme concentration of 1,762.87 U/g, pH of 6.76, temperature of 43.75 °C, extraction time of 6...
2018: PeerJ
Anca Pop, Tudor Drugan, Arno C Gutleb, Diana Lupu, Julien Cherfan, Felicia Loghin, Béla Kiss
The estrogenic and anti-estrogenic effects of butylparaben (BuPB), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and propyl gallate (PG) were evaluated for individual compounds as well as for binary mixtures, using an estrogen-dependent reporter gene assay in T47D-Kbluc breast cancer cells and an estrogen-dependent proliferation assay in MCF-7 breast cancer cells. In terms of estrogenicity the potency of the selected compounds increased from BHA < PG < BuPB in the luciferase assay (with BHT showing no significant estrogenic activity), while in the proliferation assay the following order was observed: BHT < BHA < BuPB (with PG showing no significant estrogenic activity)...
February 19, 2018: Journal of Applied Toxicology: JAT
Ashok Kumar, Deepak, Swati Sharma, Shere Afgan, Rajesh Kumar, Anand Kumar Keshari, Ragini Srivastava
The present paper reports graft copolymerization of N-vinylcaprolactam (NVCL) onto carboxymethylcellulose (CMC) using tert-butyl hydroperoxide (TBHP) initiator in N2 atmosphere. The grafting was found to be highest when concentrations of CMC, NVCL and TBHP were 6.25 × 10-2 g dm-3, 10 × 10-3 mol dm-3 and 20 × 10-5 mol dm-3 respectively. The graft copolymer (CMC-g-PNVCL-1) was characterized by FTIR, 1HNMR, SEM, AFM, XRD and TGA analysis. The antioxidant activity of the graft copolymer was found to be higher (3...
February 7, 2018: International Journal of Biological Macromolecules
Khatereh Saei Arezoumand, Effat Alizadeh, Mohammad Esmaeillou, Maryam Ghasemi, Shahriar Alipour, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami
In recent decades, mesenchymal stem cells originated from adipose tissue (adipose-derived stem cells, ASCs) have gained increased attention for production of cell-based therapeutics. Emu oil as a natural compound showed antioxidant effects in previous studies. The goal of this study was to investigate the effect of crude emu oil on the proliferation, cell cycle progression, stemness genes expression, and in vitro wound healing potential of ASCs. An emulsion of emu oil was prepared using egg lecithin and butylated hydroxytoluene to improve bioavailability and solubility of emu oil in the expansion medium...
January 29, 2018: In Vitro Cellular & Developmental Biology. Animal
Berna Özalp Özen, Ayla Soyer
The effects of different plant extracts [green tea extract (GTE), grape seed extract (GSE), and pomegranate rind extract (PRE)] at a level of 100 ppm equivalent phenolics and butylated hydroxytoluene (BHT) on the changes in quality of fish (Scomber scombrus) mince during 6 months frozen storage at -18 ± 1 °C were investigated. During storage, significant oxidative reactions in both the lipids and proteins were observed with the increase in thiobarbituric acid reactive substances (TBARS) and carbonyls and decrease in sulphydryl groups and protein solubility...
January 2018: Journal of Food Science and Technology
DooJin Lee, Ok-Hwan Lee, Geunpyo Choi, Jong Dai Kim
Trapa japonica shell contains phenolic compounds such as tannins. Studies regarding the antioxidant and anti-adipogenic effects of Trapa japonica shell cultivated in Korea are still unclear. Antioxidant and anti-adipogenic activities were measured by in vitro assays such as 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity, 2,2'-azinobis( 3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activity, ferric reducing ability of plasma assay, reducing power, superoxide dismutase-like activity, and iron chelating ability in 3T3-L1 cells...
December 2017: Preventive Nutrition and Food Science
Uzma Saleem, Saba Riaz, Bashir Ahmad, Mohammad Saleem
Background: Mortality rate is increasing due to cardiovascular problems throughout the world. These cardiac problems are directly associated with dyslipidemia. Aim: The aim of this study was to evaluate the antihyperlipidemic effect of aqueous extract and methanol extract of Trachyspermum ammi at 1 g/kg, 3 g/kg, and 5 g/kg dose levels in rats. Materials and Methods: For this purpose, 45 male albino rats were used and randomly divided into nine equal groups (n = 5)...
December 2017: Pharmacognosy Research
Maja Karaman, Ljiljana Janjušević, Dragica Jakovljević, Filip Šibul, Boris Pejin
This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively...
January 2, 2018: Natural Product Research
Barsha Dassarma, Dilip K Nandi, Somnath Gangopadhyay, Saptadip Samanta
Carbon tetrachloride (CCl4), a hepatotoxic agent is widely used to study the toxic mechanisms in experimental animals. This study was carried out to establish the hepatoprotective measures of food preservative antioxidants butylated hydroxyanisole and butylated hydroxytolune (BHA, BHT) when mixed with food towards carbon tetrachloride (CCl4) intoxication (230 mg/ kg b wt/rat/day) in rat. Biochemical markers like serum glutamate pyruvate tranaminase (AST), serum glutamate oxaloacetate transaminase (ALT), alkaline phosphatase (ALP) and bilirubin content, antioxidant enzymes such as SOD, CAT, GPx, and malondialdehyde (MDA) as the end product of lipid peroxidanion were measured...
2018: Toxicology Reports
Xiaoxi Yang, Wenting Song, Na Liu, Zhendong Sun, Ruirui Liu, Qian S Liu, Qunfang Zhou, Guibin Jiang
Synthetic phenolic antioxidants (SPAs) are closely correlated with human life due to their extensive usages, and increasing concerns have been raised on their biosafety. The previous controversial findings caused continuous debates on their potential endocrine disrupting effects. In the present study, four commonly used SPAs, including butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tert-butyl hydroquinone (TBHQ) and 2,2'-methylenebis(6-tert-butyl-4-methylphenol) (AO2246), were investigated for their estrogenic effects, and the results from in vitro screening assays showed SPAs themselves had negligible estrogen receptor binding affinities...
December 13, 2017: Environmental Science & Technology
Elmas Sari, Paweł Berczynski, Aleksandra Kładna, Irena Kruk, Oya B Dundar, Monika Szymanska, Hassan Y Aboul-Enein
BACKGROUND: A new series of 13 piperazinyl flavone derivatives has been synthesized and examined for their in vitro antiradical and antioxidant activities as response to the pharmacy industry's increasing demand for new non-toxic anti-inflammatory and anticancer drugs. METHODS: Their antioxidant activity was evaluated by the reactive oxygen species (ROS) scavenging assays, 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation (ABTS+ ) scavenging assays, and the ferric reducing antioxidant potency (TAC) method, and compared to known positive controls, herbal infusions, and penicillins...
December 3, 2017: Medicinal Chemistry
Jinfeng Yang, Myeong Ok Kim, Yong Soo Kwon, Myong Jo Kim
BACKGROUND: Rhododendron brachycarpum (RB) is a genus of flowering plants generally used for traditional medicine in Korea to treat hypertension, neuralgia, and sterility. Previous studies have shown that RB extract alleviate inflammation and antimicrobial activity. OBJECTIVE: In this study, the effects of RB and its different fractions (n-hexane, ethyl-acetate and n-butanol) on antioxidant activity, DNA damage prevention and the activity of α-glucosidase were studied...
2017: Current Pharmaceutical Biotechnology
Lukai Ma, Guoqin Liu
A group of toxic aldehydes such as, malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), and 4-hydroxy-2-nonenal (HNE) have been found in various vegetable oils and oil-based foods. Then simultaneous determination of them holds a great need in both the oil chemistry field and food field. In the present study, a simple and efficient analytical method was successfully developed for the simultaneous separation and detection of MDA, HHE, and HNE in vegetable oils by reversed-phase-high-performance liquid chromatography (RP-HPLC) coupled with photodiode array detector (PAD) at dual-channel detection mode...
December 27, 2017: Journal of Agricultural and Food Chemistry
Ruirui Zhang, Chao Li, Yunzi Li, Xinyi Cui, Lena Q Ma
We developed an analytical method to simultaneously determine 2,6-di-tert-butyl-hydroxytoluene (BHT) and its four transformation products in indoor dust and sediment samples. BHT, 2,6-di-tert-butylcyclohexa-2,5-diene-1,4-dione (BHT-Q), and 3,5-di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO) were measured by gas chromatography-mass spectrometry (GC-MS) after ultrasonic extraction with hexane/dichloromethane (1:3), while 2,6-di-tert-butyl-4-(hydroxymethyl) phenol (BHT-OH) and 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT-COOH) were derivatized using N, O-bis (trimethylsilyl) trifluoroacetamide before GC-MS analysis...
November 17, 2017: Science of the Total Environment
Mohamed Asik Rajmohamed, Suganthy Natarajan, Premkumar Palanisamy, Akbarsha Mohammad Abdulkader, Archunan Govindaraju
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by memory loss and impaired cognitive function. Cholinergic enzyme deficiency and oxidative stress are the two major factors implicated in the pathogenesis of AD. The symptomatic treatment, as of now, is the use of cholinesterase inhibitors toward cholinergic "downturn." Therefore, there is a search for compounds that will be useful in focused therapies. There has been suggestion that Terminalia chebula fruit would be a potential source...
October 2017: Pharmacognosy Magazine
Sabine Baumgartner, Ronald P Mensink, Guido R Haenen, Aalt Bast, Christoph J Binder, Otto Bekers, Constanze Husche, Dieter Lütjohann, Jogchum Plat
Despite increased serum plant sterol concentrations after consumption of plant sterol enriched margarines, plasma oxyphytosterol concentrations were not increased in healthy subjects. Here, we assessed plasma oxyphytosterol concentrations and whether they are affected by antioxidants in subjects with elevated oxidative stress. Twenty subjects with impaired glucose tolerance (IGT) or type 2 diabetes (DM2) consumed for 4 weeks placebo, vitamin E (804 mg/d) or lipoic acid capsules (600 mg/d). Plasma and blood cell oxyphytosterol and oxycholesterol concentrations were determined in butylated hydroxytoluene-enriched EDTA plasma via GC-MS...
November 10, 2017: Scientific Reports
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