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butylated hydroxytoluene

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https://www.readbyqxmd.com/read/29142396/antioxidant-and-cholinesterase-inhibitory-activities-of-ethyl-acetate-extract-of-terminalia-chebula-cell-free-in-vitro-and-in-silico-studies
#1
Mohamed Asik Rajmohamed, Suganthy Natarajan, Premkumar Palanisamy, Akbarsha Mohammad Abdulkader, Archunan Govindaraju
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by memory loss and impaired cognitive function. Cholinergic enzyme deficiency and oxidative stress are the two major factors implicated in the pathogenesis of AD. The symptomatic treatment, as of now, is the use of cholinesterase inhibitors toward cholinergic "downturn." Therefore, there is a search for compounds that will be useful in focused therapies. There has been suggestion that Terminalia chebula fruit would be a potential source...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29127425/the-effects-of-vitamin-e-or-lipoic-acid-supplementation-on-oxyphytosterols-in-subjects-with-elevated-oxidative-stress-a-randomized-trial
#2
Sabine Baumgartner, Ronald P Mensink, Guido R Haenen, Aalt Bast, Christoph J Binder, Otto Bekers, Constanze Husche, Dieter Lütjohann, Jogchum Plat
Despite increased serum plant sterol concentrations after consumption of plant sterol enriched margarines, plasma oxyphytosterol concentrations were not increased in healthy subjects. Here, we assessed plasma oxyphytosterol concentrations and whether they are affected by antioxidants in subjects with elevated oxidative stress. Twenty subjects with impaired glucose tolerance (IGT) or type 2 diabetes (DM2) consumed for 4 weeks placebo, vitamin E (804 mg/d) or lipoic acid capsules (600 mg/d). Plasma and blood cell oxyphytosterol and oxycholesterol concentrations were determined in butylated hydroxytoluene-enriched EDTA plasma via GC-MS...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108969/dietary-butylated-hydroxytoluene-improves-lipid-metabolism-antioxidant-and-anti-apoptotic-response-of-largemouth-bass-micropterus-salmoides
#3
L L Yu, H H Yu, X F Liang, N Li, X Wang, F H Li, X F Wu, Y H Zheng, M Xue, X F Liang
A 10-week growth trail was conducted to investigate the efficacy and tolerance of dietary butylated hydroxytoluene (BHT) by evaluating inflammation, apoptosis and hepatic disease related to oxidative stress in largemouth bass (Micropterus salmoides). Four experimental diets were prepared with BHT supplement levels of 0 (B0), 150 (B150), 300 (B300) and 1500 (B1500) mg/kg, in which B150 was at the maximum recommended level established by European Union Regulation, and the B300 and B1500 levels were 2 and 10-fold of B150, respectively...
November 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29096095/enzymatic-synthesis-of-1-3-dihydroxyphenylacetoyl-sn-glycerol-optimization-by-response-surface-methodology-and-evaluation-of-its-antioxidant-and-antibacterial-activities
#4
Nadia Kharrat, Imen Aissa, Youssef Dgachi, Fatma Aloui, Fakher Chabchoub, Mohamed Bouaziz, Youssef Gargouri
In this study, the enzymatic synthesis of phenylacetoyl glycerol ester was carried out as a response to the increasing consumer demand for natural compounds. 1,3-dihydroxyphenylacetoyl-sn-Glycerol (1,3-di-HPA-Gly), labeled as "natural" compound with interesting biological properties, has been successfully synthesized for the first time in good yield by a direct esterification of glycerol (Gly) with p-hydroxyphenylacetic acid (p-HPA) using immobilized Candida antarctica lipase as a biocatalyst. Spectroscopic analyses of purified esters showed that the glycerol was mono- or di-esterified on the primary hydroxyl group...
October 23, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29090445/release-of-particles-organic-compounds-and-metals-from-crumb-rubber-used-in-synthetic-turf-under-chemical-and-physical-stress
#5
Silvia Canepari, Paola Castellano, Maria Luisa Astolfi, Stefano Materazzi, Riccardo Ferrante, Dennis Fiorini, Roberta Curini
The chemical and morphological characteristics of materials released under chemical and physical stress by different rubber granulates used as infill materials in synthetic turf (recycled scrap tires, natural rubber, and a new-generation thermoplastic elastomer) were compared.The headspace solid-phase micro-extraction GC-MS analysis evidenced that at 70 °C natural rubber and thermoplastic elastomer release amounts of organic species much higher than recycled scrap tires. In particular, the desorption of mineral oils, with a prevalence of toxicologically relevant low-viscosity alkanes in the range C17-C22, and plasticizers (diisobutyl phthalate) was clearly evidenced...
October 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29054439/effect-of-storage-time-temperature-antioxidant-and-thawing-on-fatty-acid-composition-of-plasma-serum-and-red-blood-cells-a-pilot-biobank-study
#6
Pedro Araujo, Tormod Bjørkkjær, Livar Frøyland, Rune Waagbø
BACKGROUND: It studies on the factors that affect the stability of fatty acid profiles from human blood specimens are generally performed by evaluating the effect of a single factor on an individual fatty acid and excluding a considerable amount of data from the total fatty acid profiles. METHODS: The stability of fatty acids from plasma, serum and red blood cells (RBC) was evaluated in terms of time, temperature, antioxidant and thawing. The fatty acids were methylated and analyzed by gas chromatography...
October 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29037740/antioxidant-activity-of-rosemary-essential-oil-fractions-obtained-by-molecular-distillation-and-their-effect-on-oxidative-stability-of-sunflower-oil
#7
Gabriela N Mezza, Ana V Borgarello, Nelson R Grosso, Héctor Fernandez, María C Pramparo, María F Gayol
The objective of this study was to evaluate the antioxidant activity of rosemary essential oil fractions obtained by molecular distillation (MD) and investigate their effect on the oxidative stability of sunflower oil. MD fractions were prepared in a series of low-pressure stages where rosemary essential oil was the first feed. Subsequently, a distillate (D1) and residue (R1) were obtained and the residue fraction from the previous stage used as the feed for the next. The residue fractions had the largest capacity to capture free radicals, and the lowest peroxide values, conjugated dienes and conjugated trienes...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28964951/vincristine-loaded-liposomes-prepared-by-ion-paring-techniques-effect-of-lipid-ph-and-antioxidant-on-chemical-stability
#8
Yunning Yang, Yuting Guo, Xinyi Tan, Haibing He, Yu Zhang, Tian Yin, Hui Xu, Xing Tang
In the present study, vincristine (VCR)-loaded liposomes were designed by ion-pairing techniques and the model could be applied to investigate the effect of lipids on the degradation of vinca alkaloids, and how to weaken their influence by adjusting pH and adding antioxidants. It was found that there was a positive correlation between degree of degradation and the unsaturation extent of the phospholipids. In the phospholipid with the lowest oxidation index, only 6% of VCR was degraded in 6days at 37°C, whereas for the phospholipids with highest oxidation index, the degradation reached above 95% over the same time...
September 28, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28953235/comparative-evaluation-of-polyphenol-contents-and-antioxidant-activities-between-ethanol-extracts-of-vitex-negundo-and-vitex-trifolia-l-leaves-by-different-methods
#9
Sarla Saklani, Abhay Prakash Mishra, Harish Chandra, Maria Stefanova Atanassova, Milan Stankovic, Bhawana Sati, Mohammad Ali Shariati, Manisha Nigam, Mohammad Usman Khan, Sergey Plygun, Hicham Elmsellem, Hafiz Ansar Rasul Suleria
The in vitro antioxidant potential assay between ethanolic extracts of two species from the genus Vitex (Vitex negundo L. and Vitex trifolia L.) belonging to the Lamiaceae family were evaluated. The antioxidant properties of different extracts prepared from both plant species were evaluated by different methods. DPPH scavenging, nitric oxide scavenging, and β-carotene-linoleic acid and ferrous ion chelation methods were applied. The antioxidant activities of these two species were compared to standard antioxidants such as butylated hydroxytoluene (BHT), ascorbic acid, and Ethylene diamine tetra acetic acid (EDTA)...
September 27, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28942679/highly-oxygenated-antioxidative-2h-chromen-derivative-from-the-red-seaweed-gracilaria-opuntia-with-pro-inflammatory-cyclooxygenase-and-lipoxygenase-inhibitory-properties
#10
Fasina Makkar, Kajal Chakraborty
Phytochemical investigation of the thalli of ethyl acetate-methanol extract of the red seaweed Gracilaria opuntia led to isolation of a substituted 2H-chromen derivative of unusual structure possessing highly oxygenated carbon skeleton, characterised as 2-acetoxy-2-(5-acetoxy-4-methyl-2-oxotetrahydro-2H-pyran-4-yl)ethyl 4-(3-methoxy-2-(methoxymethyl)-7-methyl-3,4,4a,7,8,8a-hexahydro-2H-chromen-4-yloxy)-5-methylheptanoate, which have not been reported in nature. The chemical structure was resolved by detailed spectroscopic analysis...
September 25, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28937585/phytochemicals-extraction-isolation-and-identification-of-bioactive-compounds-from-plant-extracts
#11
REVIEW
Ammar Altemimi, Naoufal Lakhssassi, Azam Baharlouei, Dennis G Watson, David A Lightfoot
There are concerns about using synthetic phenolic antioxidants such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) as food additives because of the reported negative effects on human health. Thus, a replacement of these synthetics by antioxidant extractions from various foods has been proposed. More than 8000 different phenolic compounds have been characterized; fruits and vegetables are the prime sources of natural antioxidants. In order to extract, measure, and identify bioactive compounds from a wide variety of fruits and vegetables, researchers use multiple techniques and methods...
September 22, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28936872/characterization-of-lipophilized-monomeric-and-oligomeric-grape-seed-flavan-3-ol-derivatives
#12
Mingshun Chen, Shujuan Yu
Grape seed proanthocyanidins, composed of flavan-3-ols of different degrees of polymerization, are natural food antioxidants. Flavan-3-ols in grape seed are usually polyhydroxy derivatives which exhibit hydrophilic character. Monomeric and oligomeric flavan-3-ols were modified structurally to improve their lipophilicity, expand their application in lipophilic media, and enhance their cellular absorption in the body. The esterification of the water-soluble flavan-3-ols was prepared by Lipozyme TL IM with lauric acid, and their enhanced lipophilicity was confirmed by a 1-octanol/water partition coefficient...
October 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28927293/antileishmanial-and-antioxidant-potential-of-fractions-and-isolated-compounds-from-nectandra-cuspidata
#13
Lilian Dos Anjos Oliveira Ferreira, Mariana Maciel de Oliveira, Flávia Lais Faleiro, Débora Botura Scariot, Joana Schuelter Boeing, Jesuí Vergílio Visentainer, Mariza Barion Romagnolo, Celso Vataru Nakamura, Maria da Conceição Torrado Truiti
The effects on the viability of promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and citotoxicity in J774.A1 macrophages of ethanolic extract, fractions and isolated compounds that were obtained from the leaves of Nectandra cuspidata were determined. The total phenolics content (TP) and antioxidant activity were assessed using different assays. The ethyl acetate fraction (EAF) had the best antiproliferative activity (amastigote IC50: 4.42 ± 0.60 μg/mL, promastigote IC50: 33.33 ± 0...
September 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28915419/sensitivity-improvement-of-the-lc-ms-ms-quantification-of-carbidopa-in-human-plasma-and-urine-by-derivatization-with-2-4-pentanedione
#14
Nico C van de Merbel, Kees J Bronsema, Steven H Gorman, Ray Bakhtiar
The reliable quantification of carbidopa in biological samples at low concentrations is challenging because of the polar and highly unstable nature of the compound. In this paper, LC-MS/MS methods are described for the determination of carbidopa in 50μL of human plasma and 25μL of human urine in the concentration ranges 1-1,000ng/mL and 100-50,000ng/mL, respectively. After a simple protein precipitation (plasma) or dilution (urine) step, carbidopa is derivatized at its hydrazine moiety by reaction for one hour with 2,4-pentanedione under acidic conditions and at 40°C...
October 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28911673/impact-of-different-partitioned-solvents-on-chemical-composition-and-bioavailability-of-sasa-quelpaertensis-nakai-leaf-extract
#15
Masaya Nakamura, Jong-Hwan Ra, Youngheun Jee, Ju-Sung Kim
The leaves of Sasa quelpaertensis Nakai were extracted with 80% ethanol and further partitioned with n-hexane, chloroform, ethyl acetate, n-butanol, and aqueous fractions to evaluate the biological activity through assessment via various in vitro assays, including total phenol content; 1,1-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-(3-ethylbenzothiazothiazoline-6-sulfornic acid (ABTS) radical scavenging; reducing power; α-glucosidase and tyrosinase inhibitory; and alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity assays...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28899454/determination-of-carotenoids-in-infant-pediatric-and-adult-nutritionals-by-hplc-with-uv-visible-detection-single-laboratory-validation-first-action-2017-04
#16
Karen J Schimpf, Linda D Thompson, Shang-Jing Pan
This reversed-phase HPLC method uses C30 chromatography and UV-Vis spectroscopy to determine cis and trans isomers of lutein, β-carotene, and lycopene in infant, pediatric, and adult nutritionals. Samples are saponified with a mixture of potassium hydroxide, tetrahydrofuran, and methanol, and carotenoids are extracted from saponified samples with 75 + 25 hexane–methyl tertiary butyl ether (MtBE). After extraction, a portion of the organic layer is evaporated to dryness, and the residue is dissolved in 75 + 25 10% butylated hydroxytoluene in methanol–MtBE...
September 12, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28895793/food-stabilizing-antioxidants-increase-nutrient-bioavailability-in-the-in-vitro-model
#17
Magdalena Mika, Agnieszka Wikiera, Anna Antończyk, Maja Grabacka
OBJECTIVE: We investigated whether antioxidants may enhance bioavailability of lipids and carbohydrates and therefore increase the risk of obesity development. METHODS: We tested how supplementation with antioxidants (0.01% butylated hydroxytoluene [BHT], α-tocopherol, and green tea catechins) of a diet containing butter and wheat bread affects bioavailability of fats and carbohydrates. The absorption of the in vitro digested diet was estimated in the intestinal epithelia model of the Caco-2 cells cultured in Transwell chambers...
September 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28888144/previously-undescribed-fridooleanenes-and-oxygenated-labdanes-from-the-brown-seaweed-sargassum-wightii-and-their-protein-tyrosine-phosphatase-1b-inhibitory-activity
#18
Anusree Maneesh, Kajal Chakraborty
Previously undescribed fridooleanene triterpenoids 2α-hydroxy-(28,29)-frido-olean-12(13), 21(22)-dien-20-propyl-21-hex-4'(Z)-enoate, 2α-hydroxy-(28,29)-frido-olean-12(13), 21(22)-dien-20-prop-2(E)-en-21-butanoate and oxygenated labdane diterpenoids 2α-hydroxy-8(17), (12E), 14-labdatriene, 3β, 6β, 13α-tri hydroxy 8(17), 12E, 14-labdatriene were purified from the ethyl acetate-methanol and dichloromethane fractions of the air-dried thalli of Sargassum wightii (Sargassaceae), a brown seaweed collected from the Gulf-of-Mannar of Penninsular India...
September 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28885916/calcitriol-reverses-induced-expression-of-efflux-proteins-and-potentiates-cytotoxic-activity-of-gemcitabine-in-capan-2-pancreatic-cancer-cells
#19
Hamed Gilzad-Kohan, Shabnam Sani, Mehdi Boroujerdi
PURPOSE: Efflux and influx proteins play a major role in chemo-resistance by affecting the net cellular uptake of anti-cancer drugs. Hence, alteration of the efflux and influx protein expression may result in variations of chemotherapeutics uptake and consequently cell death rate. The present study investigated the effects of pre-treatment of capan-2 pancreatic cancer cells with calcitriol, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) or silibinin on the induction of three major efflux proteins and the main gemcitabine influx protein...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28873530/antioxidant-activities-of-ginger-extract-and-its-constituents-toward-lipids
#20
Wenhui Si, Yan Ping Chen, Jianhao Zhang, Zhen-Yu Chen, Hau Yin Chung
Lipid oxidation-a major cause of food product deterioration-necessitates the use of food additives to inhibit food oxidation. Ginger extract (GE) has been reported to possess antioxidant properties. However, components isolated from ginger have been rarely reported to inhibit fat oxidation. Herein, antioxidant properties of GE and four pure components derived from it (6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol) were examined and their properties were compared to those of butylated hydroxytoluene. GE and the constituent components exhibited antioxidant properties that might be attributed to their hydroxyl groups and suitable solubilizing side chains...
January 15, 2018: Food Chemistry
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