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butylated hydroxytoluene

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https://www.readbyqxmd.com/read/28927293/antileishmanial-and-antioxidant-potential-of-fractions-and-isolated-compounds-from-nectandra-cuspidata
#1
Lilian Dos Anjos Oliveira Ferreira, Mariana Maciel de Oliveira, Flávia Lais Faleiro, Débora Botura Scariot, Joana Schuelter Boeing, Jesuí Vergílio Visentainer, Mariza Barion Romagnolo, Celso Vataru Nakamura, Maria da Conceição Torrado Truiti
The effects on the viability of promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and citotoxicity in J774.A1 macrophages of ethanolic extract, fractions and isolated compounds that were obtained from the leaves of Nectandra cuspidata were determined. The total phenolics content (TP) and antioxidant activity were assessed using different assays. The ethyl acetate fraction (EAF) had the best antiproliferative activity (amastigote IC50: 4.42 ± 0.60 μg/mL, promastigote IC50: 33.33 ± 0...
September 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28915419/sensitivity-improvement-of-the-lc-ms-ms-quantification-of-carbidopa-in-human-plasma-and-urine-by-derivatization-with-2-4-pentanedione
#2
Nico C van de Merbel, Kees J Bronsema, Steven H Gorman, Ray Bakhtiar
The reliable quantification of carbidopa in biological samples at low concentrations is challenging because of the polar and highly unstable nature of the compound. In this paper, LC-MS/MS methods are described for the determination of carbidopa in 50μL of human plasma and 25μL of human urine in the concentration ranges 1-1,000ng/mL and 100-50,000ng/mL, respectively. After a simple protein precipitation (plasma) or dilution (urine) step, carbidopa is derivatized at its hydrazine moiety by reaction for one hour with 2,4-pentanedione under acidic conditions and at 40°C...
September 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28911673/impact-of-different-partitioned-solvents-on-chemical-composition-and-bioavailability-of-sasa-quelpaertensis-nakai-leaf-extract
#3
Masaya Nakamura, Jong-Hwan Ra, Youngheun Jee, Ju-Sung Kim
The leaves of Sasa quelpaertensis Nakai were extracted with 80% ethanol and further partitioned with n-hexane, chloroform, ethyl acetate, n-butanol, and aqueous fractions to evaluate the biological activity through assessment via various in vitro assays, including total phenol content; 1,1-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-(3-ethylbenzothiazothiazoline-6-sulfornic acid (ABTS) radical scavenging; reducing power; α-glucosidase and tyrosinase inhibitory; and alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity assays...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28899454/determination-of-carotenoids-in-infant-pediatric-and-adult-nutritionals-by-hplc-with-uv-visible-detection-single-laboratory-validation-first-action-2017-04
#4
Karen J Schimpf, Linda D Thompson, Shang-Jing Pan
This reversed-phase HPLC method uses C30 chromatography and UV-Vis spectroscopy to determine cis and trans isomers of lutein, β-carotene, and lycopene in infant, pediatric, and adult nutritionals. Samples are saponified with a mixture of potassium hydroxide, tetrahydrofuran, and methanol, and carotenoids are extracted from saponified samples with 75 + 25 hexane–methyl tertiary butyl ether (MtBE). After extraction, a portion of the organic layer is evaporated to dryness, and the residue is dissolved in 75 + 25 10% butylated hydroxytoluene in methanol–MtBE...
September 12, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28895793/food-stabilizing-antioxidants-increase-nutrient-bioavailability-in-the-in-vitro-model
#5
Magdalena Mika, Agnieszka Wikiera, Anna Antończyk, Maja Grabacka
OBJECTIVE: We investigated whether antioxidants may enhance bioavailability of lipids and carbohydrates and therefore increase the risk of obesity development. METHODS: We tested how supplementation with antioxidants (0.01% butylated hydroxytoluene [BHT], α-tocopherol, and green tea catechins) of a diet containing butter and wheat bread affects bioavailability of fats and carbohydrates. The absorption of the in vitro digested diet was estimated in the intestinal epithelia model of the Caco-2 cells cultured in Transwell chambers...
September 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28888144/previously-undescribed-fridooleanenes-and-oxygenated-labdanes-from-the-brown-seaweed-sargassum-wightii-and-their-protein-tyrosine-phosphatase-1b-inhibitory-activity
#6
Anusree Maneesh, Kajal Chakraborty
Previously undescribed fridooleanene triterpenoids 2α-hydroxy-(28,29)-frido-olean-12(13), 21(22)-dien-20-propyl-21-hex-4'(Z)-enoate, 2α-hydroxy-(28,29)-frido-olean-12(13), 21(22)-dien-20-prop-2(E)-en-21-butanoate and oxygenated labdane diterpenoids 2α-hydroxy-8(17), (12E), 14-labdatriene, 3β, 6β, 13α-tri hydroxy 8(17), 12E, 14-labdatriene were purified from the ethyl acetate-methanol and dichloromethane fractions of the air-dried thalli of Sargassum wightii (Sargassaceae), a brown seaweed collected from the Gulf-of-Mannar of Penninsular India...
September 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28885916/calcitriol-reverses-induced-expression-of-efflux-proteins-and-potentiates-cytotoxic-activity-of-gemcitabine-in-capan-2-pancreatic-cancer-cells
#7
Hamed Gilzad-Kohan, Shabnam Sani, Mehdi Boroujerdi
PURPOSE: Efflux and influx proteins play a major role in chemo-resistance by affecting the net cellular uptake of anti-cancer drugs. Hence, alteration of the efflux and influx protein expression may result in variations of chemotherapeutics uptake and consequently cell death rate. The present study investigated the effects of pre-treatment of capan-2 pancreatic cancer cells with calcitriol, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) or silibinin on the induction of three major efflux proteins and the main gemcitabine influx protein...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28873530/antioxidant-activities-of-ginger-extract-and-its-constituents-toward-lipids
#8
Wenhui Si, Yan Ping Chen, Jianhao Zhang, Zhen-Yu Chen, Hau Yin Chung
Lipid oxidation-a major cause of food product deterioration-necessitates the use of food additives to inhibit food oxidation. Ginger extract (GE) has been reported to possess antioxidant properties. However, components isolated from ginger have been rarely reported to inhibit fat oxidation. Herein, antioxidant properties of GE and four pure components derived from it (6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol) were examined and their properties were compared to those of butylated hydroxytoluene. GE and the constituent components exhibited antioxidant properties that might be attributed to their hydroxyl groups and suitable solubilizing side chains...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28865620/assessment-of-the-antioxidant-activity-of-bifurcaria-bifurcata-aqueous-extract-on-canola-oil-effect-of-extract-concentration-on-the-oxidation-stability-and-volatile-compound-generation-during-oil-storage
#9
Rubén Agregán, José M Lorenzo, Paulo E S Munekata, Ruben Dominguez, Javier Carballo, Daniel Franco
In this research the antioxidant activity of water extracts of Bifurcaria bifurcata (BBE) at different dose against butylated hydroxytoluene (BHT) was evaluated in canola oil. Water extracts were firstly characterized in terms of total solid and polyphenolic compound contents, and their antioxidant activity together with that of BHT was evaluated using several in vitro tests (DPPH, ABTS, ORAC and FRAP). Next, the progress of lipid oxidation was assessed in canola oil added with five BBE concentrations (200, 400, 600, 800 and 1000ppm) and two BHT concentrations (50 and 200ppm) using an accelerated oxidation test...
September 2017: Food Research International
https://www.readbyqxmd.com/read/28812524/biologically-important-hydrazide-containing-fused-azaisocytosines-as-antioxidant-agents
#10
Małgorzata Sztanke, Krzysztof Sztanke
OBJECTIVES: Two important classes of hydrazide-containing fused azaisocytosines were evaluated as possible antioxidants and characterised by UV spectroscopy. METHODS: 2,2-Diphenyl-1-picrylhydazyl (DPPH), nitric oxide (NO), hydrogen peroxide (H2O2) scavenging potencies and reducing power of molecules were evaluated. RESULTS: The strongest DPPH scavengers were found to be 9, showing the potency superior to that of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG) and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) and comparable to that of ascorbic acid (AA), and 6, revealing the antioxidant potency superior to that of BHA, BHT, PG and Trolox...
August 16, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28772158/novel-antioxidant-bromophenols-with-acetylcholinesterase-butyrylcholinesterase-and-carbonic-anhydrase-inhibitory-actions
#11
Necla Öztaskın, Parham Taslimi, Ahmet Maraş, İlhami Gülcin, Süleyman Göksu
In this study, a series of novel bromophenols were synthesized from benzoic acids and methoxylated bromophenols. The synthesized compounds were evaluated by using different bioanalytical antioxidant assays including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS(+)) radical scavenging assays. Also, reducing power of novel bromophenols were evaluated by Cu(2+)-Cu(+) reducing, Fe(3+)-Fe(2+) reducing and [Fe(3+)-(TPTZ)2](3+)-[Fe(2+)-(TPTZ)2]2+ reducing and ferrous ions (Fe(2+)) chelating abilities...
July 20, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28768515/a-comparative-assessment-of-antiproliferative-properties-of-resveratrol-and-ethanol-leaf-extract-of-anogeissus-leiocarpus-dc-guill-and-perr-against-hepg2-hepatocarcinoma-cells
#12
COMPARATIVE STUDY
Jeremiah Olorunjuwon Olugbami, Robert Damoiseaux, Bryan France, Esther Modupe Onibiyo, Michael Adedapo Gbadegesin, Shivani Sharma, James Kazimierz Gimzewski, Oyeronke Adunni Odunola
BACKGROUND: Epidemiological and experimental evidences have shown cancer as a leading cause of death worldwide. Although the folklore use of plants as a reliable source of health-restoring principles is well-documented, the search for more of such plants that are active against diseases, such as cancer, continues. We report here a laboratory-based evidence of the relevance of an ethanol leaf extract of Anogeissus leiocarpus (A2L) in comparison with resveratrol, a natural polyphenol, in cancer therapy...
August 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28768445/single-walled-carbon-nanotube-multi-walled-carbon-nanotube-and-fe2o3-nanoparticles-induced-mitochondria-mediated-apoptosis-in-melanoma-cells
#13
Parvaneh Naserzadeh, Fatemeh Ansari Esfeh, Mahboubeh Kaviani, Khadigeh Ashtari, Raheleh Kheirbakhsh, Ahmad Salimi, Jalal Pourahmad
PURPOSE: Nanomaterials (NM) exhibit novel anticancer properties. MATERIALS AND METHODS: The toxicity of three nanoparticles that are currently being produced in high tonnage including single-walled carbon nanotube (SWCNT), multi-walled carbon nanotube (MWCNT) and Fe2O3 nanoparticles, were compared with normal and melanoma cells. RESULTS: All tested nanoparticles induced selective toxicity and caspase 3 activation through mitochondria pathway in melanoma cells and mitochondria cause the generating of reactive oxygen species (ROS), mitochondrial membrane potential decline (MMP collapse), mitochondria swelling and cytochrome c release...
August 2, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28764086/graphite-nanocomposites-sensor-for-multiplex-detection-of-antioxidants-in-food
#14
Khan Loon Ng, Guan Huat Tan, Sook Mei Khor
Butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and tert-butylhydroquinone (TBHQ) are synthetic antioxidants used in the food industry. Herein, we describe the development of a novel graphite nanocomposite-based electrochemical sensor for the multiplex detection and measurement of BHA, BHT, and TBHQ levels in complex food samples using a linear sweep voltammetry technique. Moreover, our newly established analytical method exhibited good sensitivity, limit of detection, limit of quantitation, and selectivity...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28763999/antioxidant-effects-of-extra-virgin-olive-oil-enriched-by-myrtle-phenolic-extracts-on-iron-mediated-lipid-peroxidation-under-intestinal-conditions-model
#15
Sofiane Dairi, Marie-Annette Carbonneau, Teresa Galeano-Diaz, Hocine Remini, Farid Dahmoune, Omar Aoun, Amine Belbahi, Céline Lauret, Jean-Paul Cristol, Khodir Madani
Chelating and free radicals scavenging activities of extra virgin olive oil (EVOO) enriched by Myrtus communis phenolic compounds (McPCs), α-tocopherol and Butylated hydroxytoluene (BHT) were evaluated using chemical assays, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Oxygen radical absorbance capacity (ORAC), and biological model as 2,2'-azobis (2-aminopropane) dihydrochloride (AAPH) or Fe(+3)/Ascorbic acid (Fe(+3)/AsA) system mediated peroxidation of l-α-phosphatidylcholine aqueous dispersions stabilized by bile salts (BS) under simulated intestinal conditions (pH 7...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28751215/protective-effects-of-4-methylcoumarins-and-related-compounds-as-radical-scavengers-and-chain-breaking-antioxidants
#16
Vessela D Kancheva, Adriana K Slavova-Kazakova, Silvia E Angelova, Suraj K Singh, Shashwat Malhotra, Brajendra K Singh, Luciano Saso, Ashok K Prasad, Virinder S Parmar
The aim of this study is to determine, and to compare the protective effects of eight 4-methylcoumarins and four related compounds as radical scavengers and chain-breaking antioxidants. The main kinetic parameters of their radical scavenging activity (as % RSA, stoichiometry, n, and rate constants of reaction with DPPH radical, kRSA) and of chain breaking antioxidant activity (as antioxidant efficiency, PF and reactivity, ID), have been determined and discussed. The RSA study has been conducted at physiological temperature (37 °С) towards DPPH radical and the tested compounds are separated into three main groups: with strong activity (% RSA > 40%); with moderate activity (20% < % RSA > 40%) and with weak activity (% RSA < 20%)...
September 2017: Biochimie
https://www.readbyqxmd.com/read/28740307/evaluations-of-physicochemical-and-anti-oxidant-properties-of-powdered-leaves-from-lotus-shepherd-s-purse-and-goldenrod-in-restructured-duck-pork-patties
#17
Juhui Choe, Yuan H Brad Kim, Hack-Youn Kim, Cheon-Jei Kim
The objective of this study was to determine the effects of powdered leaves of lotus (LP), shepherd's purse (SP) and goldenrod (GP) on oxidation stability and quality characteristics of cooked duck/pork patties. Fresh duck tenderloin (M. pectoralis) and pork meat (M. biceps femoris, semitendinosus, and semimembranosus) were ground, formulated with LP, SP, GP or butylated hydroxytoluene (BHT), and mixed with other non-meat ingredients. The manufactured patties were cooked, packaged, and stored at 3 °C for 4 weeks...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28718990/fungitoxicity-of-organic-extracts-of-ocimum-basilicum-on-growth-and-morphogenesis-of-bipolaris-species-teleomorph-cochliobolus
#18
E A Elsherbiny, N A Safwat, M M Elaasser
AIMS: This study aimed at evaluating the inhibitory effects of various organic extracts of Ocimum basilicum against some species of Bipolaris and Cochliobolus with GC-MS and HPLC analysis. METHODS AND RESULTS: The ethyl acetate extract consisted of methyl cinnamate as the most abundant component, while butylated hydroxytoluene was the major component in the methanol extract. Pyrogallol and chlorogenic acid were major phenolic compounds in the ethyl acetate and methanol extracts, respectively...
July 18, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28672060/phytochemical-and-biological-activities-of-pseudocalymma-elegans-a-false-garlic
#19
Sana Wahid, Muhammad Ali Versiani, Sajid Jahangir, Khurshid Jawaid, Maryam Shafique, Huma Khan, Shaheen Faizi
Evaluation of phytochemical constituents and antioxidant and antimicrobial activities of hexane (PELH), dichloromethane (PELDCM), ethyl acetate (PELEA) and methanolic (PELM) extracts of young leaves of P. elegans have been carried out. Moreover, extracts have also been explored for the presence of sulphur containing compounds, 1, 2-dithiolane (33), diallyl disulphide (35), 3-Vinyl-1,2-dithiacyclohex-5-ene (37), diallyl trisulphide (38) responsible for the garlic like smell of P. elegans. All the extracts were found to be antioxidant and showed potent inhibition with IC50 values 0...
July 3, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28633498/thymol-as-natural-antioxidant-additive-for-poultry-feed-oxidative-stability-improvement
#20
A Luna, R C Lema-Alba, J S Dambolena, J A Zygadlo, M C Labaque, R H Marin
Antioxidant are regularly included in poultry feed as protection from deterioration during storage. Recently the interest for the use of natural phytochemicals in animal diets has been increased. Thymol (THY) has been proven to be an effective antioxidant for extending broiler meat quality during storage with similar action to the widely used butylated hydroxytoluene (BHT). This study evaluates whether THY can also have a protective effect on the feed mash by assessing its antioxidant potential and related changes in fatty acid (FA) balance...
September 1, 2017: Poultry Science
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