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https://www.readbyqxmd.com/read/28102440/thyroid-hormones-retinol-and-clinical-parameters-in-relation-to-mercury-and-organohalogen-contaminants-in-great-blue-heron-ardea-herodias-nestlings-from-the-st-lawrence-river-qu%C3%A3-bec-canada
#1
Louise Champoux, Monique Boily, Guy Fitzgerald
The exposure and effects of persistent environmental contaminants were investigated in great blue heron (Ardea herodias) nestlings sampled in 2001, 2002, 2006, and 2007 in freshwater and estuarine heronries along the St. Lawrence River, Québec (Canada). Biomarkers (retinoids, thyroid hormones, and clinical parameters) and contaminants (organochlorine contaminants, polychlorinated biphenyls (PCBs), brominated flame retardants (BFRs), and mercury (Hg)) were analyzed in blood, and Hg was analyzed in feathers (generally 9 nestlings per colony and 4 colonies per year)...
January 19, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28102015/circulating-antioxidant-levels-and-risk-of-prostate-cancer-by-tmprss2-erg
#2
Rebecca E Graff, Gregory Judson, Thomas U Ahearn, Michelangelo Fiorentino, Massimo Loda, Edward L Giovannucci, Lorelei A Mucci, Andreas Pettersson
BACKGROUND: Few studies have considered etiological differences across molecular subtypes of prostate cancer, despite potential to improve opportunities for precision prevention of a disease for which modifiable risk factors have remained elusive. Factors that lead to DNA double-strand breaks, such as oxidative stress, may promote the formation of the TMPRSS2:ERG gene fusion in prostate cancer. We tested the hypothesis that increasing levels of pre-diagnostic circulating antioxidants, which may reduce oxidative stress, are associated with lower risk of developing TMPRSS2:ERG positive prostate cancer...
January 19, 2017: Prostate
https://www.readbyqxmd.com/read/28100868/growth-inhibition-of-refractory-human-gallbladder-cancer-cells-by-retinol-and-its-mechanism-of-action
#3
Chuan Li, Masahiko Imai, Shinya Hasegawa, Masahiro Yamasaki, Noriko Takahashi
Among the constituents of the essential nutrient vitamin A, retinol is a potent suppressor of refractory cancer cell growth linked to tumor progression, showing greater efficacy than retinoic acid (RA). However, the mechanisms of retinol action on human refractory cancer are not known well. In the current study, we examined the actions of retinol on proliferation of human gallbladder cancer NOZ C-1 cells. Retinol and RA inhibited the proliferation of human NOZ C-1 cells in dose-dependent manner, while RA was less potent than retinol...
January 18, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100867/effects-of-pre-and-post-administration-of-vitamin-a-on-the-growth-of-refractory-cancers-in-xenograft-mice
#4
Chuan Li, Masahiko Imai, Masahiro Yamasaki, Shinya Hasegawa, Noriko Takahashi
Vitamin A is an essential nutrient that is obtained from the daily diet. The major forms of vitamin A in the body consist of retinol, retinal, retinoic acid (RA), and retinyl esters. Retinal is fundamental for vision and RA is used in clinical therapy of human acute promyelocytic leukemia. The actions of retinol and retinyl palmitate (RP) are not known well. Recently, we found that retinol is a potent anti-proliferative agent against human refractory cancers, including gallbladder cancer, being more effective than RA, while RP was inactive...
January 18, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28096191/allosteric-modulation-of-the-substrate-specificity-of-acyl-coa-wax-alcohol-acyltransferase-2-awat2
#5
Jason M Arne, Made Airanthi K Widjaja-Adhi, Taylor Hughes, Kevin W Huynh, Josie A Silvaroli, Sylwia Chelstowska, Vera Y Moiseenkova-Bell, Marcin Golczak
The esterification of alcohols with fatty acids is a universal mechanism to form inert storage forms of sterols, di- and triacylglycerols, and retinoids. In ocular tissues, formation of retinyl esters is an essential step in the enzymatic regeneration of the visual chromophore (11-cis-retinal). Acyl-CoA wax alcohol acyltransferase 2 (AWAT2), also known as multifunctional O-acyltransferase (MFAT), is an integral membrane enzyme with a broad substrate specificity that has been shown to preferentially esterify 11-cis-retinol and thus contribute to formation of readily available pool of cis retinoids in the eye...
January 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28095558/clinical-evaluation-of-a-4-hydroquinone-1-retinol-treatment-regimen-for-improving-melasma-and-photodamage-in-fitzpatrick-skin-types-iii-vi
#6
Marta I Rendon, Sylvia Barkovic
The bene ts of monotherapy with hydroquinone for melasma and retinoids for photodamaged skin is well established. Here we report results of a hydroquinone skincare regimen designed for melasma treatment combined with a cosmetic retinol cream on subjects presenting with both melasma and facial photodamage in a 24-week study. Improvement in melasma and photodamage ef cacy pa- rameters of melasma pigmentation intensity and melasma area and severity index (MASI), as well as overall photodamage and mottled hyperpigmentation were found by week 4, the rst post-baseline time point...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095529/open-label-study-evaluating-the-anti-aging-effects-of-a-3-product-2-step-retinol-rejuvenation-system-following-3-months-of-treatment-in-subjects-with-photodamage
#7
Suzanne Bruce, Sylvia Barkovic
BACKGROUND: Photodamage to the skin occurs with exposure to sunlight (UVA or UVB) either intentionally or unintentionally, and can present in a variety of ways. It typically occurs on areas of chronic UV exposure, including the face, ears, and neck. METHODS: We evaluated the effects of a 3-product, 2-step retinol-rejuvenation system containing an exfoliating cleanser, a 0.5% retinol emollient cream, and SPF 30 moisturizing sunscreen used daily for 3 months on the appearance of mild-to-moderate facial photodamage in female subjects...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28094879/nutritional-inflammatory-and-ecological-correlates-of-maternal-retinol-allocation-to-breast-milk-in-agro-pastoral-ariaal-communities-of-northern-kenya
#8
Masako Fujita, Yun-Jia Lo, Eleanor Brindle
OBJECTIVES: Vitamin A (VA) is an essential micronutrient required for a range of biological functions throughout life. VA deficiency (VAD) claims an estimated 1 million preschool children's lives annually. Human milk is enriched with VA (retinol) from the maternal blood, which originates from the hepatic reserve and dietary intake. Secreting retinol into milk will benefit the nursing infant through breast milk, but retaining retinol is also important for the maternal health. Previous studies found that the public health intervention of high-dose VA supplementation to lactating mothers did not significantly lower child mortality...
January 17, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28091905/activity-of-lpo-processes-in-women-with-polycystic-ovarian-syndrome-and-infertility
#9
L I Kolesnikova, S I Kolesnikov, M A Darenskaya, L A Grebenkina, O A Nikitina, L M Lazareva, L V Suturina, I N Danusevich, E B Druzhinina, A A Semendyaev
Specific features of LPO processes and antioxidant defense were studied in patients with polycystic ovarian syndrome (PCOS) and infertility. Changes in LPO processes in patients with PCOS were compensatory, which manifested in increased α-tocopherol and retinol concentrations and moderate decrease in superoxide dismutase activity. Intensification of prooxidant processes was found in the group of patients with infertility without PCOS. The observed changes necessitate differentiated approach to the treatment of these patients...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28078954/nanovesicle-delivery-to-the-liver-via-retinol-binding-protein-and-platelet-derived-growth-factor-receptors-how-targeting-ligands-affect-biodistribution
#10
Ching-Yun Hsu, Chun-Han Chen, Ibrahim A Aljuffali, You-Shan Dai, Jia-You Fang
AIM: Nanovesicles (NVs) conjugating ligands can deliver to the specific nidus. We designed a nanosystem targeting the injectable niosomes to liver for examining biodistribution. METHODOLOGY: Vitamin A and antiplatelet-derived growth factor receptor antibody were employed as the ligands to be taken by hepatic stellate cells. The biodistribution in rats was visualized by bioimaging. RESULTS: A significant liver accumulation was detected for antibody-embedded NVs at 2 h after dosing...
January 12, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28074976/utility-of-urinary-markers-in-the-assessment-of-renal-dysfunction-in-canine-babesiosis
#11
Dagmara Winiarczyk, Łukasz Adaszek, Michał Bartnicki, Beata Abramowicz, Paweł Łyp, Jacek Madany, Stanisław Winiarczyk
OBJECTIVE: Canine babesiosis is a common and clinically significant tick-borne disease caused by haemoprotozoan parasites of the genus Babesia. Acute renal failure is considered to be one of the most prevalent complications of canine babesiosis. This complication leads to a decrease in the glomerular filtration rate and in consequence causes azotemia and uremia. The objective of this study was to assess the localization and extent of renal damage in dogs infected with Babesia canis using an urinary marker for glomerular (urinary immunoglobulin G, uIgG), proximal tubular dysfunction (urinary retinol binding protein, uRBP) and distal tubular dysfunction (urinary Tamm-Horsfal protein, uTHP)...
January 11, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28073161/the-pnpla3-i148m-variant-modulates-the-fibrogenic-phenotype-of-human-hepatic-stellate-cells
#12
Francesca Virginia Bruschi, Thierry Claudel, Matteo Tardelli, Alessandra Caligiuri, Thomas M Stulnig, Fabio Marra, Michael Trauner
: The genetic polymorphism I148M of PNPLA3 is robustly associated with hepatic steatosis and its progression to steatohepatitis, fibrosis and cancer. Hepatic stellate cells (HSCs) are key players in the development of liver fibrosis, but the role of PNPLA3 and its variant I148M in this process is poorly understood. Here we analyzed the expression of PNPLA3 during human HSC activation and thereby explored how a PNPLA3 variant impacts on hepatic fibrogenesis. We show that PNPLA3 gene and protein expression increase during the early phases of activation and remain elevated in fully activated HSCs (p<0...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28070301/blood-serum-retinol-levels-in-asinara-white-donkeys-reflect-albinism-induced-metabolic-adaptation-to-photoperiod-at-mediterranean-latitudes
#13
Maria Grazia Cappai, Maria Grazia Antonietta Lunesu, Francesca Accioni, Massimo Liscia, Mauro Pusceddu, Lucia Burrai, Maria Nieddu, Corrado Dimauro, Gianpiero Boatto, Walter Pinna
Previous works on albinism form of Asinara white donkeys (Equus asinus) identified the mutation leading to the peculiar phenotype spread to all specimens of the breed. Inbreeding naturally occurred under geographic isolation, on Asinara Island, in the Mediterranean Sea. Albino individuals can be more susceptible to develop health problems when exposed to natural sun radiation. Alternative metabolic pathways involved in photoprotection were explored in this trial. Nutrition-related metabolites are believed to contribute to the conservation of Asinara donkeys, in which melanin, guaranteeing photoprotection, is lacking...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28065603/retinoic-acid-induces-hypersegmentation-and-enhances-cytotoxicity-of-neutrophils-against-cancer-cells
#14
Sanjeeb Shrestha, Shin-Yeong Kim, Young-Jin Yun, Jun-Kyu Kim, Jae Man Lee, Minsang Shin, Dong-Keun Song, Chang-Won Hong
Hypersegmentation of nuclei is considered a distinct characteristic of the antitumoral phenotype of neutrophils. Retinoic acid, a metabolite of retinol, reorganizes and induces segmentation of the nucleus during the differentiation of neutrophils. However, the role of retinoic acid in the phenotype polarization of neutrophils has not been fully established. Here, we investigated the effect of retinoic acid on phenotype polarization of neutrophils. Retinoic acid-induced the hypersegmentation of human neutrophils via retinoic acid receptors and mTOR pathways...
January 5, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28057518/structural-and-molecular-determinants-affecting-the-interaction-of-retinol-with-human-crbp1
#15
Ilaria Menozzi, Francesca Vallese, Eugenia Polverini, Claudia Folli, Rodolfo Berni, Giuseppe Zanotti
Four cellular retinol-binding protein (CRBP) types (CRBP1,2,3,4) are encoded in the human genome. Here, we report on X-ray analyses of human apo- and holo-CRBP1, showing nearly identical structures, at variance with the results of a recent study on the same proteins containing a His-Tag, which appears to be responsible for a destabilizing effect on the apoprotein. The analysis of crystallographic B-factors for our structures indicates that the putative portal region, in particular α-helix-II, along with Arg58 and the E-F loop, is the most flexible part of both apo- and holoprotein, consistent with its role in ligand uptake and release...
January 2, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28045436/retinol-and-%C3%AE-tocopherol-in-the-breast-milk-of-women-after-a-high-risk-pregnancy
#16
Reyna Sámano, Hugo Martínez-Rojano, Rosa M Hernández, Cristina Ramírez, María E Flores Quijano, José M Espíndola-Polis, Daniela Veruete
BACKGROUND: There is scant information about whether, after a high-risk pregnancy, breast milk provides enough vitamins for assuring satisfactory bodily reserves in newborns. OBJECTIVE: To comparatively evaluate, in women with high-risk and normal pregnancy, the concentration of retinol and α-tocopherol in breast milk. METHODS: This cross-sectional, analytical study was evaluated with reverse-phase high-performance liquid chromatography (HPLC)...
January 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28038989/increased-plasma-rbp4-concentration-in-older-hypertensives-is-related-to-the-decreased-kidney-function-and-the-number-of-antihypertensive-drugs-results-from-the-polsenior-substudy
#17
Marcin Majerczyk, Piotr Choręza, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Habibullah Arabzada, Aleksander Owczarek, Małgorzata Mossakowska, Tomasz Grodzicki, Tomasz Zdrojewski, Andrzej Więcek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
Increased plasma retinol-binding protein 4 (RBP4), a novel adipokine, has been associated in previous studies with obesity, type 2 diabetes, dyslipidemia, hypertension (HT), atherosclerosis, and coronary artery disease. This study aimed to analyze the relationship between HT occurrence and its treatment, and plasma RBP4 concentrations in the older polish population. The study sample consisted of 1728 (890 men and 838 women) PolSenior study participants aged 65 years and older with available plasma samples and NT-proBNP values below 2000 pg/mL...
December 7, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28035980/hepatic-retinyl-ester-hydrolases-and-the-mobilization-of-retinyl-ester-stores
#18
REVIEW
Lukas Grumet, Ulrike Taschler, Achim Lass
For mammals, vitamin A (retinol and metabolites) is an essential micronutrient that is required for the maintenance of life. Mammals cannot synthesize vitamin A but have to obtain it from their diet. Resorbed dietary vitamin A is stored in large quantities in the form of retinyl esters (REs) in cytosolic lipid droplets of cells to ensure a constant supply of the body. The largest quantities of REs are stored in the liver, comprising around 80% of the body's total vitamin A content. These hepatic vitamin A stores are known to be mobilized under times of insufficient dietary vitamin A intake but also under pathological conditions such as chronic alcohol consumption and different forms of liver diseases...
December 27, 2016: Nutrients
https://www.readbyqxmd.com/read/28034750/computing-the-binding-affinity-of-a-ligand-buried-deep-inside-a-protein-with-the-hybrid-steered-molecular-dynamics
#19
Oscar D Villarreal, Lili Yu, Roberto A Rodriguez, Liao Y Chen
Computing the ligand-protein binding affinity (or the Gibbs free energy) with chemical accuracy has long been a challenge for which many methods/approaches have been developed and refined with various successful applications. False positives and, even more harmful, false negatives have been and still are a common occurrence in practical applications. Inevitable in all approaches are the errors in the force field parameters we obtain from quantum mechanical computation and/or empirical fittings for the intra- and inter-molecular interactions...
December 26, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28027671/nutrition-status-of-primary-school-students-in-two-rural-regions-of-guinea-bissau
#20
Edward Saltzman, Nina Schlossman, Carrie A Brown, Ionela Balan, Paul Fuss, Payal Batra, Augusto Braima de Sa, Mary Kyla Shea, William M Pruzensky, Carlito Bale, Susan B Roberts
BACKGROUND: The nutrition status of primary schoolchildren in Africa has received relatively little attention in comparison to that of younger children. We surveyed primary school students in Guinea-Bissau, a nation that is among the poorest in the world. OBJECTIVE: Anthropometry and prevalence of anemia and vitamin A deficiency were assessed in schoolchildren participating in International Partnership for Human Development's school feeding program in 2 regions of Guinea-Bissau...
January 1, 2016: Food and Nutrition Bulletin
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