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https://www.readbyqxmd.com/read/27911779/retinoic-acid-signaling-determines-the-fate-of-uterine-stroma-in-the-mouse-m%C3%A3-llerian-duct
#1
Tadaaki Nakajima, Taisen Iguchi, Tomomi Sato
The Müllerian duct develops into the oviduct, uterus, and vagina, all of which are quite distinct in their morphology and function. The epithelial fate of these female reproductive organs in developing mice is determined by factors secreted from the stroma; however, how stromal differentiation occurs in the female reproductive organs derived from the Müllerian duct is still unclear. In the present study, roles of retinoic acid (RA) signaling in developing female reproductive tracts were investigated. Retinol dehydrogenase 10 (RDH10) and aldehyde dehydrogenase family 1 subfamily A2 (ALDH1A2) mRNAs and proteins and transactivation activity of endogenous RA were found in the stroma of proximal Müllerian ducts and gradually decreased from the proximal to caudal regions in fetal mice...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27906964/undernutrition-vitamin-a-and-iron-deficiency-are-associated-with-impaired-intestinal-mucosal-permeability-in-young-bangladeshi-children-assessed-by-lactulose-mannitol-test
#2
Md Iqbal Hossain, Rashidul Haque, Dinesh Mondal, Mustafa Mahfuz, Am Shamsir Ahmed, M Munirul Islam, Richard L Guerrant, William A Petri, Tahmeed Ahmed
BACKGROUND: Lactulose/mannitol (L:M) test has been used as a non-invasive marker of intestinal mucosal -integrity and -permeability (enteropathy). We investigated the association of enteropathy with anthropometrics, micronutrient- status, and morbidity in children. METHODS: The urine and blood samples were collected from 925 children aged 6-24 months residing in Mirpur slum of Dhaka, Bangladesh during November 2009 to April 2013. L:M test and micronutrient status were assessed in the laboratory of International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b) following standard procedure...
2016: PloS One
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#3
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27894252/transcriptome-analysis-reveals-the-genetic-basis-underlying-the-seasonal-development-of-keratinized-nuptial-spines-in-leptobrachium-boringii
#4
Wei Zhang, Yue Guo, Jun Li, Li Huang, Eric Gilbert Kazitsa, Hua Wu
BACKGROUND: The expression of sexually selected traits often varies with populations' breeding cycles in many animals. The elucidation of mechanisms underlying the expression of such traits is a research topic in evolutionary biology; however, the genetic basis of the seasonal development of their expression remains unknown. Male Leptobrachium boringii develop keratinized nuptial spines on their upper jaw during the breeding season that fall off when the breeding season ends. To illuminate the genetic basis for the expression of this trait and its seasonal development, we assessed the de novo transcriptome for L...
November 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27890019/vitamin-a-deficiency-and-determinants-of-vitamin-a-status-in-bangladeshi-children-and-women-findings-of-a-national-survey
#5
Sabuktagin Rahman, Ahmed Shafiqur Rahman, Nurul Alam, Am Shamsir Ahmed, Santhia Ireen, Ireen Akhter Chowdhury, Fatima Parveen Chowdhury, Sm Mustafizur Rahman, Tahmeed Ahmed
OBJECTIVE: Using data from the national micronutrients survey 2011-2012, the present study explored the status of subclinical vitamin A nutrition and the underlying determinants in the Bangladeshi population. DESIGN: A nationwide cross-sectional study. Settings The survey covered 150 clusters; fifty in each of rural, urban and slum strata. SUBJECTS: Three population groups: (i) pre-school age children (6-59 months; PSAC); (ii) school age children (6-14 years; SAC); and (iii) non-pregnant non-lactating women (15-49 years; NPNLW)...
November 28, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27879948/efficacy-and-local-tolerability-of-different-spray-products-in-the-treatment-of-mild-to-moderate-acne-of-the-back-and-chest-a-controlled-3-arm-assessor-blinded-prospective-trial
#6
Ada Lo Schiavo, Rosa V Puca, Francesca Romano, Massimo Milani
BACKGROUND: A spray formulation containing 2 vitamin-A derivatives (hydroxypinacolone retinoate and retinol) carried in glycospheres (RetinSphere®) combined with an antimicrobial peptide (BIOPEP-15), salicylic acid and vitamin E (BR) has been recently developed for the treatment of truncal acne. We evaluated clinical efficacy of BR in comparison with two commonly used sprays, containing triethylcitrate and ethylinoleate (AK) and containing betaine, glycine and salicylic acid 2% (SP)...
November 23, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27879662/retinol-dehydrogenases-regulate-vitamin-a-metabolism-for-visual-function
#7
REVIEW
Bhubanananda Sahu, Akiko Maeda
The visual system produces visual chromophore, 11-cis-retinal from dietary vitamin A, all-trans-retinol making this vitamin essential for retinal health and function. These metabolic events are mediated by a sequential biochemical process called the visual cycle. Retinol dehydrogenases (RDHs) are responsible for two reactions in the visual cycle performed in retinal pigmented epithelial (RPE) cells, photoreceptor cells and Müller cells in the retina. RDHs in the RPE function as 11-cis-RDHs, which oxidize 11-cis-retinol to 11-cis-retinal in vivo...
November 22, 2016: Nutrients
https://www.readbyqxmd.com/read/27878895/polymorphisms-of-rdh16-and-vegfr1-influence-m-trapezius-steatosis-in-japanese-black-carcass
#8
Takafumi Ishida, Kosuke Noda, Fortune Ntengwa Jomane, Tadaaki Tokunaga
The exact cause of steatosis, one of defects in Japanese beef carcasses, has not been elucidated to date, because it is very difficult to diagnose cyclopedically with certain reproducibility due to the bias in the outbreak. Therefore, the objective of this study was to assess the influence of polymorphisms in retinol dehydrogenase 16 (RDH16), myoferlin (MYOF) and vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2) on carcass-graded Musculus trapezius steatosis. For logistic regression analysis, 646 carcasses shipped from 29 farms in Miyazaki, Japan, were used...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27877091/conserved-chemosensory-proteins-in-the-proboscis-and-eyes-of-lepidoptera
#9
Jiao Zhu, Immacolata Iovinella, Francesca Romana Dani, Yu-Ling Liu, Ling-Qiao Huang, Yang Liu, Chen-Zhu Wang, Paolo Pelosi, Guirong Wang
Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are endowed with several different functions besides being carriers for pheromones and odorants. Based on a previous report of a CSP acting as surfactant in the proboscis of the moth Helicoverpa armigera, we revealed the presence of orthologue proteins in two other moths Plutella xylostella and Chilo suppressalis, as well as two butterflies Papilio machaon and Pieris rapae, using immunodetection and proteomic analysis. The unusual conservation of these proteins across large phylogenetic distances indicated a common specific function for these CSPs...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27865848/retinol-dehydrogenase-13-deficiency-diminishes-carbon-tetrachloride-induced-liver-fibrosis-in-mice
#10
Xiaofang Cui, Suying Dang, Yan Wang, Yan Chen, Jia Zhou, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang
Retinol dehydrogenase 13 (RDH13) is a mitochondrion-localized member of the short-chain dehydrogenases/reductases (SDRs) superfamily that participates in metabolism of some compounds. Rdh13 mRNA is most highly expressed in mouse liver. Rdh13 deficiency reduces the extent of liver injury and fibrosis, reduces hepatic stellate cell (HSC) activation, attenuates collagen I (II), tissue inhibitor of metalloproteinase 1 (TIMP-1) and transforming growth factor beta 1 (Tgf-β1) expression. The results indicate an important role of Rdh13 and suggest RDH13 as a possible new therapeutic target for CCl4-induced fibrosis...
November 16, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27865810/improvement-of-anthropometric-and-biochemical-but-not-of-vitamin-a-status-in-adolescents-who-undergo-roux-en-y-gastric-bypass-a-1-year-follow-up-study
#11
Jacqueline Souza Silva, Gabriela Villaça Chaves, Ana Paula Stenzel, Silvia Elaine Pereira, Carlos José Saboya, Andréa Ramalho
BACKGROUND: The aim of this study was to describe anthropometric, biochemical, co-morbidity, and vitamin A nutritional status in severely obese adolescents before and 30, 180, and 365 days after Roux-en-Y gastric bypass (RYGB). SETTING: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. METHODS: Sixty-four adolescents (15-19 years old) with a body mass index≥40 kg/m(2) were enrolled in a prospective follow-up study. Vitamin A status was evaluated before surgery (T0), and 30 (T30), 180 (T180), and 365 (T365) days after surgery, applying biochemical and functional indicators...
September 12, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27863993/association-between-micronutrients-intake-status-and-carotid-intima-media-thickness-a-systematic-review
#12
Banafshe Hosseini, Ahmad Saedisomeolia, Michael R Skilton
BACKGROUND: Carotid intima media thickness (IMT) is a noninvasive marker of the extent and severity of subclinical atherosclerosis. Micronutrient intake may affect atherosclerosis and play a major role in the development of cardiovascular diseases (CVDs). OBJECTIVE: The primary aim of this review was to synthesize the evidence regarding the association between carotid IMT and selected micronutrients. METHOD: The authors searched PubMed, Cochrane, and EMBASE databases from inception to June 2016 for selected micronutrients, CVD, carotid IMT, and antioxidants...
November 15, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27862386/no-detectable-carotenoid-concentrations-in-serum-of-llamas-and-alpacas
#13
J Raila, F J Schweigert, A Stanitznig, B Lambacher, S Franz, S Baldermann, T Wittek
Carotenoids are lipid-soluble pigments and important for a variety of physiological functions. They are major dietary vitamin A precursors and act as lipophilic antioxidants in a variety of tissues and are associated with important health benefits in humans and animals. All animals must acquire carotenoids from their diet, but to our knowledge, there are no studies investigating the intestinal carotenoid absorption and their blood concentrations in New World camelids. The present study aimed to assess the serum concentrations of selected carotenoids in llamas (n = 13) and alpacas (n = 27)...
November 9, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27862054/determination-of-target-fat-soluble-micronutrients-in-rainbow-trout-s-muscle-and-liver-tissues-by-liquid-chromatography-with-diode-array-tandem-mass-spectrometry-detection
#14
Virginia Pérez Fernández, Salvatore Ventura, Pierpaolo Tomai, Roberta Curini, Alessandra Gentili
This paper describes an analytical approach, based on liquid chromatography-diode array detection-tandem mass spectrometry (LC-DAD-MS/MS), for characterizing the fat-soluble micronutrient fraction in rainbow trout (Oncorhynchus mykiss). Two different procedures were applied to isolate the analytes from liver and muscle tissue: overnight cold saponification to hydrolyze bound forms and to simplify the analysis; matrix solid phase dispersion (MSPD) to avoid artifacts and to maintain unaltered the naturally occurring forms...
November 12, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27856824/all-trans-retinoic-acid-augments-the-histopathological-outcome-of-neuroinflammation-and-neurodegeneration-in-lupus-prone-mrl-lpr-mice
#15
Michelle H Theus, Joshua B Sparks, Xiaofeng Liao, Jingjing Ren, Xin M Luo
Recently, we demonstrated that treatment with all-trans-retinoic acid (tRA) induced a paradoxical effect on immune activation during the development of autoimmune lupus. Here, we further describe its negative effects on mediating neuroinflammation and neurodegeneration. Female MRL/lpr mice were orally administered tRA or VARA (retinol mixed with 10% tRA) from 6 to 14 weeks of age. Both treatments had a significant effect on brain weight, which correlated with histopathological evidence of focal astrogliosis, meningitis, and ventriculitis...
November 16, 2016: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/27856323/opinion-of-the-scientific-committee-on-consumer-safety-sccs-final-version-of-the-opinion-on-vitamin-a-retinol-retinyl-acetate-and-retinyl-palmitate-in-cosmetic-products
#16
Christophe Rousselle
No abstract text is available yet for this article.
November 14, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27847115/pre-therapeutic-nutritional-assessment-for-predicting-severe-adverse-events-in-patients-with-head-and-neck-cancer-treated-by-radiotherapy
#17
Takeyuki Kono, Koji Sakamoto, Seiichi Shinden, Kaoru Ogawa
BACKGROUND & AIMS: Malnutrition is common in patients with head and neck cancer (HNSCC). It may be related to severe adverse toxicity as a result of radiotherapy. The aim was to investigate nutritional screening factors for severe adverse events. METHODS: A retrospective chart review of 101 patients who underwent radiotherapy from 2009 to 2013 was performed. The relationships among severe adverse events and pretreatment nutritional parameters, including static variables (serum albumin, total protein, total lymphocyte counts, body mass index), dynamic variables (retinol-binding protein, transferrin, pre-albumin), and nutritional screening tools (Onodera's Prognostic Nutrition Index [O-PNI]; Nutrition Risk Index; Controlling Nutritional Status [CONUT] score; Nutritional Risk Screening 2002) were evaluated in addition to patient and treatment factors...
November 5, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27846214/proteomic-profiling-for-identification-of-novel-biomarkers-differentially-expressed-in-human-ovaries-from-polycystic-ovary-syndrome-patients
#18
Li Li, Jiangyu Zhang, Qingshan Deng, Jieming Li, Zhengfen Li, Yao Xiao, Shuiwang Hu, Tiantian Li, Qiuxiao Tan, Xiaofang Li, Bingshu Luo, Hui Mo
OBJECTIVES: To identify differential protein expression pattern associated with polycystic ovary syndrome (PCOS). METHODS: Twenty women were recruited for the study, ten with PCOS as a test group and ten without PCOS as a control group. Differential in-gel electrophoresis (DIGE) analysis and mass spectroscopy were employed to identify proteins that were differentially expressed between the PCOS and normal ovaries. The differentially expressed proteins were further validated by western blot (WB) and immunohistochemistry (IHC)...
2016: PloS One
https://www.readbyqxmd.com/read/27845741/cst-an-herbal-formula-exerts-anti-obesity-effects-through-brain-gut-adipose-tissue-axis-modulation-in-high-fat-diet-fed-mice
#19
AbuZar Ansari, Shambhunath Bose, Mukesh Kumar Yadav, Jing-Hua Wang, Yun-Kyung Song, Seong-Gyu Ko, Hojun Kim
The brain, gut, and adipose tissue interact to control metabolic pathways, and impairment in the brain-gut-adipose axis can lead to metabolic disorders, including obesity. Chowiseungcheng-tang (CST), a herbal formulation, is frequently used to treat metabolic disorders. Here, we investigated the anti-obesity effect of CST and its link with brain-gut-adipose axis using C57BL/6J mice as a model. The animals were provided with a normal research diet (NRD) or high-fat diet (HFD) in absence or presence of CST or orlistat (ORL) for 12 weeks...
November 11, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27843308/dietary-vitamin-c-intake-protects-against-copd-the-korea-national-health-and-nutrition-examination-survey-in-2012
#20
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Jae Yeol Kim, Yu-Il Kim, Kwang-Ha Yoo, Eun Mi Chun, Ji Ye Jung, Sang Haak Lee, Chul Min Ahn
BACKGROUND: Vitamin C, as an antioxidant, has recently been suggested to provide protection against COPD; however, only few national cohort studies have investigated these effects. We aimed to confirm the protective effects of vitamin C against COPD in Korean patients. PATIENTS AND METHODS: We analyzed the data of 3,283 adults aged ≥40 years (representing 23,541,704 subjects) who underwent pulmonary function tests and responded to questionnaires on smoking history and vitamin C intake, with stratification variables and sampling weight designated by the Korea 2012 National Health and Nutrition Examination Survey...
2016: International Journal of Chronic Obstructive Pulmonary Disease
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