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https://www.readbyqxmd.com/read/28426766/activated-entomopathogenic-nematode-infective-juveniles-release-lethal-venom-proteins
#1
Dihong Lu, Marissa Macchietto, Dennis Chang, Mirayana M Barros, James Baldwin, Ali Mortazavi, Adler R Dillman
Entomopathogenic nematodes (EPNs) are unique parasites due to their symbiosis with entomopathogenic bacteria and their ability to kill insect hosts quickly after infection. It is widely believed that EPNs rely on their bacterial partners for killing hosts. Here we disproved this theory by demonstrating that the in vitro activated infective juveniles (IJs) of Steinernema carpocapsae (a well-studied EPN species) release venom proteins that are lethal to several insects including Drosophila melanogaster. We confirmed that the in vitro activation is a good approximation of the in vivo process by comparing the transcriptomes of individual in vitro and in vivo activated IJs...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28426339/fasting-levels-of-insulin-and-amylin-after-acute-pancreatitis-are-associated-with-pro-inflammatory-cytokines
#2
Nicola A Gillies, Sayali A Pendharkar, Ruma G Singh, John A Windsor, Madhav Bhatia, Maxim S Petrov
BACKGROUND: The prevalence of metabolic diseases continues to rise worldwide, with a growing recognition of metabolic dysregulation after acute inflammatory diseases such as acute pancreatitis (AP). Adipokines and cytokines play an important role in metabolism and the course of AP, but there is a paucity of research investigating their relationship with pancreatic hormones after AP. This study aimed to explore associations between pancreatic hormones with adipokines and cytokines to provide insights into the pathophysiology of altered pancreatic hormone secretion following AP...
April 20, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28424257/an-animal-source-food-supplement-increases-micronutrient-intakes-and-iron-status-among-reproductive-age-women-in-rural-vietnam
#3
Andrew G Hall, Tu Ngu, Hoang T Nga, Phi N Quyen, Pham T Hong Anh, Janet C King
Background: Few studies have examined the impact of local animal-source foods (ASFs) on the nutritional status of reproductive-age women in developing countries.Objective: We hypothesized that a midmorning snack of local ASF for 6 mo would reduce dietary micronutrient deficiencies [usual intake less than the estimated average requirement (EAR)] and improve blood biomarkers of iron, zinc, and vitamins A and B-12 status among nonpregnant, reproductive-age women in rural Vietnam.Methods: One hundred seventeen women, 18-30 y old, were randomly assigned to receive either an ASF (mean: 144 kcal, 8...
April 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28424186/circulating-concentrations-of-biomarkers-and-metabolites-related-to-vitamin-status-one-carbon-and-the-kynurenine-pathways-in-us-nordic-asian-and-australian-populations
#4
Øivind Midttun, Despoina Theofylaktopoulou, Adrian McCann, Anouar Fanidi, David C Muller, Klaus Meyer, Arve Ulvik, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang, Ross Prentice, Cynthia A Thomson, Mary Pettinger, Graham G Giles, Allison Hodge, Qiuyin Cai, William J Blot, Jie Wu, Mikael Johansson, Johan Hultdin, Kjell Grankvist, Victoria L Stevens, Marjorie L McCullough, Stephanie J Weinstein, Demetrius Albanes, Arnulf Langhammer, Kristian Hveem, Marit Næss, Howard D Sesso, J Michael Gaziano, Julie E Buring, I-Min Lee, Gianluca Severi, Xuehong Zhang, Jiali Han, Meir J Stampfer, Stephanie A Smith-Warner, Anne Zeleniuch-Jacquotte, Loic le Marchand, Jian-Min Yuan, Lesley M Butler, Woon-Puay Koh, Renwei Wang, Yu-Tang Gao, Ulrika Ericson, Emily Sonestedt, Regina G Ziegler, Neal D Freedman, Kala Visvanathan, Miranda R Jones, Caroline Relton, Paul Brennan, Mattias Johansson, Per M Ueland
Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies.Objective: We robustly and comprehensively assessed differences in biomarkers that are related to vitamin status across geographic regions.Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium...
April 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28421798/assessment-of-individual-carotenoid-and-vitamin-a-dietary-intake-in-overweight-and-obese-dominican-subjects
#5
Madeline Durán-Cabral, Irene Fernández-Jalao, Rocío Estévez-Santiago, Begoña Olmedilla Alonso
INTRODUCTION: Carotenoids are plant pigment with important biological activities in humans, such as provitamin-A among others. At present, there are no individual carotenoid intake data in the Dominican population, which is at risk of vitamin A deficiency and has an important percentage of overweight and obese individuals . OBJECTIVE: To assess the individual components of vitamin A intake (retinol, α-carotene, β-carotene and β-cryptoxanthin) and that of other relevant dietary carotenoids like lutein, zeaxanthin and lycopene of Dominican daily food intake...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421130/antiretroviral-therapy-initiation-alters-the-redox-system-of-asymptomatic-hiv-infected-individuals-a-longitudinal-study
#6
Karen Ingrid Tasca, Juliana Trindade Caleffi, Camila Renata Correa, Mariana Gatto, Francilene Capel Tavares, Caio Cavassan Camargo, Alexandrina Sartori, Mara Biasin, Lenice do Rosário de Souza
Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters. This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: <500 cell/mL; G2: >500 cell/mL) before (M0) and after (M1) cART initiation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28420480/comparative-analysis-of-granulosa-cell-gene-expression-in-association-with-oocyte-competence-in-fsh-stimulated-holstein-cows
#7
David A Landry, Chloé Fortin, Anne-Marie Bellefleur, Rémi Labrecque, François-Xavier Grand, Christian Vigneault, Patrick Blondin, Marc-André Sirard
Ovarian stimulation with exogenous FSH followed by FSH withdrawal or 'coasting' is an effective means of increasing the number of oocytes obtainable for the in vitro production of cattle embryos. However, the quality of the oocytes thus obtained varies considerably from one cow to the next. The aim of the present study was to gain a better understanding of the follicular conditions associated with low oocyte developmental competence. Granulosa cells from 94 Holstein cows in a commercial embryo production facility were collected following ovarian stimulation and coasting...
April 19, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28413425/association-of-retinol-binding-protein-4-with-metabolic-syndrome-in-first-degree-relatives-of-type-2-diabetic-patients
#8
Marjan Tabesh, Atsa Noroozi, Masood Amini, Awat Feizi, Sahar Saraf-Bank, Maryam Zare
BACKGROUND: Retinol-binding protein 4 (RBP4) is known to regulate lipid and glucose metabolism and insulin resistance. The influences of RBP4 on metabolic syndrome (MS) are still unclear. The purpose of this study is to evaluate the association between serum levels of RBP4 and MS components in first-degree relations of type 2 diabetic patients. MATERIALS AND METHODS: This cross-sectional study was performed within the framework of the diabetes prevention project in Isfahan...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28408942/identification-of-tengfu-jiangya-tablet-target-biomarkers-with-quantitative-proteomic-technique
#9
Jingwen Xu, Yunlun Li, Shijun Zhang, Haiqiang Jiang, Nan Wang, Haiqing Lin
Tengfu Jiangya Tablet (TJT) is a well accepted antihypertension drug in China and its major active components were Uncaria total alkaloids and Semen Raphani soluble alkaloid. To further explore treatment effects mechanism of TJT on essential hypertension, a serum proteomic study was performed. Potential biomarkers were quantified in serum of hypertension individuals before and after taking TJT with isobaric tags for relative and absolute quantitation (iTRAQ) coupled two-dimensional liquid chromatography followed electrospray ionization-tandem mass spectrometry (2D LC-MS/MS) proteomics technique...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28404834/promotion-of-orange-fleshed-sweet-potato-increased-vitamin-a-intakes-and-reduced-the-odds-of-low-retinol-binding-protein-among-postpartum-kenyan-women
#10
Amy Webb Girard, Frederick Grant, Michelle Watkinson, Haile Selassie Okuku, Rose Wanjala, Donald Cole, Carol Levin, Jan Low
Background: Orange-fleshed sweet potato (OFSP) improves vitamin A (VA) status of young children; research with pregnant and lactating women is limited.Objective: We examined the effectiveness of the Mama SASHA (Sweetpotato Action for Security and Health in Africa) program to improve nutrition knowledge, diets, and nutritional status of pregnant and lactating women (PLW) in Western Kenya.Methods: Eight health facilities were allocated to the Mama SASHA intervention or comparison arms. PLW in intervention facilities received enhanced nutrition counseling at health clinics, were linked with community-based maternal support groups, and received vouchers for OFSP vine cuttings...
April 12, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28403785/apoptotic-effects-of-some-tetrahydronaphthalene-derivatives-on-k562-human-chronic-myelogenous-leukemia-cell-line
#11
Aslı Koç, Tulin Ozkan, Arzu Zeynep Karabay, Yalda Hekmatshoar, Ayse Selen Gurkan-Alp, Fugen Aktan, Zeliha Buyukbingol, Asuman Sunguroglu, Erdem Buyukbingol
BACKGROUND: Retinoids are synthetic and naturally occurring derivatives of vitamin A (retinol) which have been suggested to mediate inhibition of cancer cell growth and apoptosis. It has been reported that all trans retinoic acid (ATRA) exhibited suppressive effects on different types of leukemia including chronic myelogenous leukemia. OBJECTIVE: In the present study, we aim to find out the effects of 6 synthetic N-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-yl)-carboxamide derivatives (compound 6-12) on cell viability and apoptotic pathways in K562 human chronic myelogenous leukemia cell line...
April 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28400700/serum-retinol-binding-protein-induced-endothelial-inflammation-is-mediated-through-the-activation-of-toll-like-receptor-4
#12
Mei Du, Ashley Martin, Franklin Hays, Jennifer Johnson, Rafal A Farjo, Krysten M Farjo
PURPOSE: Elevation of serum retinol-binding protein 4 (RBP4) induces inflammation in primary human retinal microvascular endothelial cells (HRECs) via a retinol-independent mechanism; thus, it may play a causative role in the development and progression of vascular lesions in diabetic retinopathy (DR). Since HRECs do not express the classical RBP4 receptor, stimulated by retinoic acid gene 6 (STRA6), this study focuses on identifying the endothelial cell receptor and signaling that mediate RBP4-induced inflammation...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28394339/nspc1-promotes-cancer-stem-cell-self-renewal-by-repressing-the-synthesis-of-all-trans-retinoic-acid-via-targeting-rdh16-in-malignant-glioma
#13
P-S Hu, Q-S Xia, F Wu, D-K Li, Y-J Qi, Y Hu, Z-Z Wei, S-S Li, N-Y Tian, Q-F Wei, L-J Shen, B Yin, T Jiang, J-G Yuan, B-Q Qiang, W Han, X-Z Peng
Polycomb group (PcG) proteins play an important role in development and stem cell maintenance, and their dysregulation have been closely linked to oncogenesis and cancer stem cell phenotypes. Here, we found that nervous system polycomb 1 (NSPc1) was highly expressed in stem cell-like glioma cells (SLCs). Knockdown of NSPc1 in SLCs resulted in impaired neurosphere formation and self-renewal abilities, down-regulated expression of stemness markers such as NESTIN, CD133 and SOX2, and decreased capacity to propagate subcutaneous xenografts...
April 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28390257/exploring-the-reactivity-of-retinol-radical-cation-toward-organic-and-biological-molecules-a-laser-flash-photolysis-study
#14
Ali El-Agamey, Thor B Melø, Hans-Richard Sliwka
Vitamin A (retinol) and various natural retinoids are essential for life. Under oxidative conditions, vitamin A radical cation (RET(+)) can be formed. Many deleterious effects were reported about the formation of carotenoid radical cations in biological environments, on the other hand, little is known about the consequences of the RET(+) formation in these environments. Therefore, it is important to explore the reactivity of RET(+) toward various biological substrates. Here, we employed nanosecond laser flash photolysis (LFP) to generate RET(+) (λmax=580nm in methanol) and examine its reactivity toward a wide range of biological molecules including amino acids, vitamins, carotenoids, naturally-occurring phenols, neurotransmitters such as catecholamines, wide range of phenol derivatives and some selected electron-donors...
March 14, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28386384/association-of-serum-carotenoid-retinol-and-tocopherol-concentrations-with-the-progression-of-parkinson-s-disease
#15
Ji Hyun Kim, Jinah Hwang, Eugene Shim, Eun-Jung Chung, Sung Hee Jang, Seong-Beom Koh
BACKGROUND/OBJECTIVES: A pivotal role of oxidative stress has been emphasized in the pathogenesis as well as in the disease progression of Parkinson's disease (PD). We aimed at investigating serum levels of antioxidant vitamins and elucidating whether they could be associated with the pathogenesis and progression of PD. MATERIALS/METHODS: Serum levels of retinol, α- and γ-tocopherols, α- and β-carotenes, lutein, lycopene, zeaxanthin and β-cryptoxanthin were measured and compared between 104 patients with idiopathic PD and 52 healthy controls matched for age and gender...
April 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28381532/single-high-dose-vitamin-a-supplementation-to-neonatal-piglets-results-in-a-transient-dose-response-in-extrahepatic-organs-and-sustained-increases-in-liver-stores
#16
Bryan M Gannon, Christopher R Davis, Nivedita Nair, Michael Grahn, Sherry A Tanumihardjo
Background: Neonatal vitamin A (VA) supplementation is being evaluated as a public health policy for preventing infant mortality, but inconsistencies in mortality trials demand mechanistic work to determine biological plausibility.Objectives: We investigated the absorption, distribution, and storage of single large oral VA doses administered shortly after birth.Methods: Fifty pregnant sows (Sus scrofas domesticas) were fed a VA-free diet. Male and female newborn piglets (n = 313) were orally administered 0, 25,000, 50,000, or 200,000 IU VA in oil within 12 h of birth when mean ± SD weight was 1...
April 5, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28380009/impact-of-fortified-biscuits-on-micronutrient-deficiencies-among-primary-school-children-in-bangladesh
#17
Alayne M Adams, Rushdia Ahmed, A H M Mahbub Latif, Sabrina Rasheed, Sumon K Das, Enamul Hasib, Fahmida Dil Farzana, Farzana Ferdous, Shahnawaz Ahmed, Asg Faruque
BACKGROUND: Micronutrient deficiencies can compromise the development potential of school-aged children, and their later health and productivity as adults. School feeding and school-based fortification approaches have been utilized globally to redress nutritional deficiencies in this age group. OBJECTIVE: We explored the acceptability and micronutrient impact of a Bangladesh Government supported school-based micronutrient fortification program for children attending rural primary schools in 10 disadvantaged sub-districts...
2017: PloS One
https://www.readbyqxmd.com/read/28373527/linking-metabolic-dysfunction-to-atherosclerosis-via-activation-of-macrophage-cd36-gene-transcription-by-retinol-binding-protein-4
#18
EDITORIAL
Roy L Silverstein
No abstract text is available yet for this article.
April 4, 2017: Circulation
https://www.readbyqxmd.com/read/28368329/vitamin-a-oral-supplementation-induces-oxidative-stress-and-suppresses-il-10-and-hsp70-in-skeletal-muscle-of-trained-rats
#19
Lyvia Lintzmaier Petiz, Carolina Saibro Girardi, Rafael Calixto Bortolin, Alice Kunzler, Juciano Gasparotto, Thallita Kelly Rabelo, Cristiane Matté, José Claudio Fonseca Moreira, Daniel Pens Gelain
Exercise training intensity is the major variant that influences the relationship between exercise, redox balance, and immune response. Supplement intake is a common practice for oxidative stress prevention; the effects of vitamin A (VA) on exercise training are not yet described, even though this molecule exhibits antioxidant properties. We investigated the role of VA supplementation on redox and immune responses of adult Wistar rats subjected to swimming training. Animals were divided into four groups: sedentary, sedentary + VA, exercise training, and exercise training + VA...
April 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28359879/a-comparison-of-fat-soluble-antioxidants-in-wild-and-farm-reared-chukar-partridges-alectoris-chukar
#20
Filiz Karadas, Anders Pape Møller, Mehmet Reşit Karageçili
This study assessed differences in antioxidant (carotenoid, retinol, retinol-ester, vitamin E and coenzyme Q10) composition of egg yolk and tissue in chukar partridges (Alectoris chukar) newly hatched from eggs of birds maintained in captivity on commercial maize-soybean based diets and birds from the wild whose diet was obtained from the natural environment. All eggs were incubated in a commercial hatchery. Day-old chicks from both groups were sacrificed and dissected for antioxidant analysis. Fat soluble antioxidant concentrations of egg yolk and tissues were determined by HPLC...
March 27, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
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