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https://www.readbyqxmd.com/read/28337854/silk-fibroin-biomaterial-shows-safe-and-effective-wound-healing-in-animal-models-and-a-randomized-controlled-clinical-trial
#1
Wei Zhang, Longkun Chen, Jialin Chen, Lingshuang Wang, Xuexian Gui, Jisheng Ran, Guowei Xu, Hongshi Zhao, Mengfeng Zeng, Junfeng Ji, Li Qian, Jianda Zhou, Hongwei Ouyang, Xiaohui Zou
Due to its excellent biological and mechanical properties, silk fibroin has been intensively explored for tissue engineering and regenerative medicine applications. However, lack of translational evidence has hampered its clinical application for tissue repair. Here a silk fibroin film is developed and its translational potential is investigated for skin repair by performing comprehensive preclinical and clinical studies to fully evaluate its safety and effectiveness. The silk fibroin film fabricated using all green chemistry approaches demonstrates remarkable characteristics, including transmittance, fluid handling capacity, moisture vapor permeability, waterproofness, bacterial barrier properties, and biocompatibility...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28315557/oncolytic-viruses-treatment-and-implications-for-patients-with-gliomas%C3%A2
#2
Cheryl Martin
BACKGROUND: Oncolytic viral therapies are increasingly being explored for the treatment of diverse cancer types, most notably melanoma. However, advances in the treatment of high-grade gliomas, and specifically glioblastoma multiforme (GBM), are the result of novel oncolytic viral therapies. Delta-24-RGD is one such therapy that has demonstrated promising results in phase 1 trials.
. OBJECTIVES: The objective of this article is to provide an overview of Delta-24-RGD, highlighting considerations for nurses in diverse clinical, research, and advanced practice roles...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28315551/immunotherapy-administration-oncology-nursing-society-recommendations%C3%A2
#3
Kristine B LeFebvre, Lisa Wall, Abigail Baldwin-Medsker, Kim Nguyen, Lisa Marsh, Diane Baniewicz
As the use of immunotherapeutic agents increases in single-agent and multimodality treatment regimens, oncology nurses face the challenge of administering and caring for patients receiving new and unique agents. Oncology Nursing Society clinical staff and clinical nurses collaborated to produce a set of recommendations to educate nurses involved with the monitoring of patients receiving immunotherapy on administration procedures and safe handling of these agents to ensure patient and staff safety and to reduce risk of error...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28238087/bone-regeneration-in-the-stem-cell-era-safe-play-for-the-patient
#4
Estella Musacchio, Nicola Veronese
The past decade has seen outstanding scientific progress in the field of stem cell (SC) research and clinical application. SCs are convenient both technically and biologically: they are easy to find and to culture and they can differentiate in virtually all tissues and even in whole organs. Induced pluripotent stem cells (iPSs) are a type of pluripotent SC generated in vitro directly from mature cells through the introduction of key transcription factors. The use of iPSs, however tantalizing, poses serious safety concerns because of their genomic instability...
February 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28223874/towards-safety-of-oral-anti-cancer-agents-the-need-to-educate-our-pharmacists
#5
Sanaa Saeed Mekdad, Adher Dhaya AlSayed
Introduction: The global prevalence of cancer is rising. Use of oral anticancer medications has expanded exponentially. Knowledge about these medications as well as safe handling guidelines has not kept abreast with the rapidity these medications are applied in clinical practice. They pose serious hazards on all personal involved in handling these medications as well as on patients and their caregivers. We addressed the gaps in knowledge and safe handling of oral anticancer agents among pharmacists in institutional based cancer care...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28216170/-thymomectomy-by-minimally-invasive-surgery-comparative-study-videosurgery-versus-robot-assisted-surgery
#6
A Witte Pfister, J-M Baste, N Piton, M Bubenheim, J Melki, A Wurtz, C Peillon
OBJECTIVES: To report the results of minimally invasive surgery in patients with stage I or II thymoma in the Masaoka classification. The reference technique is partial or complete thymectomy by sternotonomy. METHODS: A retrospective single-center study of a prospective database including all cases of thymoma operated from April 2009 to February 2015 by minimally invasive techniques: either videosurgery (VATS) or robot-assisted surgery (RATS). The surgical technique, type of resection, length of hospital stay, postoperative complications and recurrences were analysed...
February 16, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28212466/withdrawn-propranolol-for-migraine-prophylaxis
#7
REVIEW
Klaus Linde, Karin Rossnagel
BACKGROUND: Propranolol is one of the most commonly prescribed drugs for migraine prophylaxis. OBJECTIVES: We aimed to determine whether there is evidence that propranolol is more effective than placebo and as effective as other drugs for the interval (prophylactic) treatment of patients with migraine. SEARCH METHODS: Potentially eligible studies were identified by searching MEDLINE/PubMed (1966 to May 2003) and the Cochrane Central Register of Controlled Trials (Issue 2, 2003), and by screening bibliographies of reviews and identified articles...
February 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28205037/the-mesenteric-defects-in-laparoscopic-roux-en-y-gastric-bypass-5-years-follow-up-of-non-closure-versus-closure-using-the-stapler-technique
#8
Ebrahim Aghajani, Bent J Nergaard, Bjorn G Leifson, Jan Hedenbro, Hjortur Gislason
BACKGROUND: Internal hernia (IH) is a common complication of laparoscopic Roux-en-Y gastric bypass (LRYGB). Little large-volume data exist on how to handle the mesenteric defects during LRYGB. This study evaluated long-term follow-up (5.5 years) of 2443 patients with primary closure of the mesenteric defects with a stapling device at LRYGB, in comparison with a non-closed group from the same centre. METHODS: All patients (N = 4013) undergoing LRYGB over a 10-year period (2005-2015) at a single institution were evaluated...
February 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28195836/understanding-nurses-strategies-to-handle-un-wanted-nurse-calls-a-resilience-perspective
#9
Joakim Klemets, Tor Erik Evjemo
Nurse calls in a hospital can constitute either positive or negative (wanted or unwanted) interruptions depending on various factors. This study aims to understand nurses' strategies in facilitating the reception of wanted nurse calls and the restriction of unwanted nurse calls. Applying a resilience engineering perspective, nurses' performance variability is investigated as a basis to design appropriate computer support to enhance efficiency and patient safety. A qualitative case study was conducted for a period of 4 years with focus on nurses' use of a wireless nurse call system at a Norwegian university hospital...
February 13, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28195827/initial-results-of-an-evidence-based-safe-patient-handling-and-mobility-program-to-decrease-hospital-worker-injuries
#10
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28187028/comparison-of-surgeon-specialty-in-open-ventral-hernia-repair
#11
Chris M Reid, Michael G Brandel, Amanda A Gosman
BACKGROUND: Ventral hernia repair is a common procedure and is undertaken by surgeons with varying training backgrounds. Outcomes after hernia repair depend on numerous factors, some being patient or surgeon specific. It remains unclear what the ideal roles are for general and plastic surgeons in open ventral hernia repair. We hypothesized that open ventral hernia repair by plastic surgeons is safe and comparable with general surgeons. METHODS: We performed a retrospective observational study using data from the National Surgical Quality Improvement Program database from 2007 to 2013...
February 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28176498/successful-laparoscopic-distal-pancreatectomy-for-a-large-solid-pseudopapillary-neoplasm-a-case-report
#12
Seiichiro Tada, Taku Iida, Takayuki Anazawa, Shintaro Yagi, Satoru Seo, Toshihiko Masui, Toshimi Kaido, Kyoichi Takaori, Shinji Uemoto
A 30-year-old Japanese woman presented at our hospital with a pancreatic tumor. Contrast-enhanced CT revealed a tumor with a 12-cm diameter in the pancreatic body and tail. In the preoperative setting, endoscopic ultrasound-guided fine-needle aspiration permitted a histopathological diagnosis of solid pseudopapillary neoplasm. Twhe patient underwent laparoscopic distal pancreatectomy with splenectomy. Our procedure involved three steps. Firstly, the splenic artery was occluded to block inflow of blood to the tumor...
February 8, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28166902/a-multi-component-patient-handling-intervention-improves-attitudes-and-behaviors-for-safe-patient-handling-and-reduces-aggression-experienced-by-nursing-staff-a-controlled-before-after-study
#13
Bettina Wulff Risør, Sven Dalgas Casper, Lars Louis Andersen, Jan Sørensen
This study evaluated an intervention for patient-handling equipment aimed to improve nursing staffs' use of patient handling equipment and improve their general health, reduce musculoskeletal problems, aggressive episodes, days of absence and work-related accidents. As a controlled before-after study, questionnaire data were collected at baseline and 12-month follow-up among nursing staff at intervention and control wards at two hospitals. At 12-month follow-up, the intervention group had more positive attitudes towards patient-handling equipment and increased use of specific patient-handling equipment...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28152802/integrating-nursing-into-oral-chemotherapy-education
#14
Nancy Weinstein, Jessica A Zerillo
81 Background:The shift of chemotherapy administration from the oncology infusion suite to the home has unwound systems and left patients vulnerable to errors. Many of the safeguards for parenteral chemotherapy, including education by an oncology nurse, are absent for oral chemotherapy. The 2013 American Society of Clinical Oncology/Oncology Nursing Society Standards served as the framework for improving the initiation of oral chemotherapy at Beth Israel Deaconess Medical Center. METHODS: Clinicians caring for patients with melanoma and renal cell cancer were surveyed...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28147385/presentation-of-a-sedation-standard-using-the-example-of-transesophageal-echocardiographies-tee-in-pediatric-outpatients
#15
H Sauer, J Pfeifer, S Gräber, H Abdul-Khaliq
Introduction Most pediatric patients require deep sedation for a TEE examination. We analyzed the data of our sedation protocols relating to all outpatient TEEs in patients under 18 years of age for the year 2011. On the basis of the data records of a total of 40 patients, we will describe our standard and compare it with the findings of the international literature. Material and Methods In a retrospective analysis, we inspected our sedation protocols in terms of patient-related data, vital parameters, drug applications, occurring complications and necessary interventions as well as nausea and vomiting during the post-sedative monitoring phase...
January 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28122477/design-and-preliminary-evaluation-of-a-self-steering-pneumatically-driven-colonoscopy-robot
#16
Hossein Dehghani, C Ross Welch, Abolfazl Pourghodrat, Carl A Nelson, Dmitry Oleynikov, Prithviraj Dasgupta, Benjamin S Terry
Colonoscopy is a diagnostic procedure to detect pre-cancerous polyps and tumours in the colon, and is performed by inserting a long tube equipped with a camera and biopsy tools. Despite the medical benefits, patients undergoing this procedure often complain about the associated pain and discomfort. This discomfort is mostly due to the rough handling of the tube and the creation of loops during the insertion. The overall goal of this work is to minimise the invasiveness of traditional colonoscopy. In pursuit of this goal, this work presents the development of a semi-autonomous colonoscopic robot with minimally invasive locomotion...
January 26, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28075650/pharmacokinetic-evaluation-of-pregabalin-for-the-treatment-of-generalized-anxiety-disorder
#17
REVIEW
Massimiliano Buoli, Alice Caldiroli, Marta Serati
Pregabalin is an alternative compound to SSRIs and SNRIs for the first-line treatment of generalized anxiety disorder (GAD). Areas covered: We describe the pharmacokinetic properties of pregabalin and their implications for the treatment of GAD. A search in the main database sources (Medline, ISI, Web of Knowledge and Medscape) was performed in order to obtain a comprehensive and balanced evaluation about the clinical implications of the pharmacokinetic properties of pregabalin in the treatment of GAD. The word "pregabalin" was associated with "pharmacokinetics", "interactions"', "GAD", "anxiety" and "tolerability"...
March 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28050366/practices-of-health-care-personnel-regarding-occupational-exposure
#18
Manisha Jain, Ekadashi Rajni Sabharwal, Dhirendra Srivastava
INTRODUCTION: With advancing health care sciences, the prevalence of Accidental Exposure to Patient's Blood (AEBP) amongst Health Care Personnel (HCP) is bound to increase. The only means of preventing such accidental exposure is safe working practices. It is the responsibility of the teachers to inculcate these practices amongst their students. AIM: To evaluate the knowledge, practice and attitude regarding Post Exposure Prophylaxis (PEP) and Hepatitis-B Virus (HBV) immunization amongst faculty and undergraduate students and to assess the frequency of these occupational exposure with the objective of inculcating safe working practices in the teaching curriculum...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28045237/safe-approach-to-the-splenic-hilum-by-first-mobilizing-the-pancreatic-tail-in-laparoscopic-splenectomy
#19
Katsunori Sakamoto, Goro Honda, Masanao Kurata, Yuki Homma, Satoshi Shinya, Masahiko Honjo
INTRODUCTION: We employed a safe approach during laparoscopic splenectomy by first mobilizing the pancreatic tail and then dissecting the splenic vessels at the splenic hilum before mobilizing the spleen. MATERIALS AND SURGICAL TECHNIQUE: Patients were placed in the lithotomy position, and only the upper body was twisted to the right side. Five trocars were placed. After the bursa omentalis was opened, an avascular layer was identified behind the pancreas. This avascular layer was bluntly dissected, and the pancreatic tail was isolated from the retroperitoneum...
February 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/27991024/-cooperation-between-the-plastic-surgery-and-the-head-neck-surgery-departments-in-the-treatment-of-unusual-cases-veszpr%C3%A3-m-hungary-2010-2015
#20
Zoltán Lóderer, József Piffkó, Károly Somlai, Gábor Bognár, Gábor Sándor
INTRODUCTION: Handling problems in the head and neck region often requires a close cooperation between allied professions, just as in the challenging cases presented by us. Cases and methodology: With the first patient, we performed a radical surgery on the left side of the face due to recidivious basal cell carcinoma, followed by reconstruction using a Type I chimeric anterolateral thigh flap (ALT), while in the case of the second patient, we carried out a radical surgery on the right side of the face due to epithelial carcinoma and reconstruction with a Type I chimeric thoracodorsal flap...
December 2016: Magyar Sebészet
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