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https://www.readbyqxmd.com/read/27748834/mek-inhibitors-against-met-amplified-non-small-cell-lung-cancer
#1
Masato Chiba, Yosuke Togashi, Shuta Tomida, Hiroshi Mizuuchi, Yu Nakamura, Eri Banno, Hidetoshi Hayashi, Masato Terashima, Marco A De Velasco, Kazuko Sakai, Yoshihiko Fujita, Tetsuya Mitsudomi, Kazuto Nishio
Several receptor tyrosine kinases (RTKs) including EGFR, ALK, and MET have been identified as therapeutic targets in non-small cell lung cancer (NSCLC). Among the downstream pathways of RTKs, the MAPK pathway is particularly important for cancer cell proliferation, differentiation, and survival. In this study, the effects of MEK inhibitors (trametinib and PD0325901) in several NSCLC cell lines with driver gene alterations, especially RTK genes, were tested in vitro using an MTT assay, and a wide range of sensitivities was found...
October 17, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27206577/generation-of-neural-crest-like-cells-from-human-periodontal-ligament-cell-derived-induced-pluripotent-stem-cells
#2
Atsushi Tomokiyo, Kim Hynes, Jia Ng, Danijela Menicanin, Esther Camp, Agnes Arthur, Stan Gronthos, P Mark Bartold
Neural crest cells (NCC) hold great promise for tissue engineering, however the inability to easily obtain large numbers of NCC is a major factor limiting their use in studies of regenerative medicine. Induced pluripotent stem cells (iPSC) are emerging as a novel candidate that could provide an unlimited source of NCC. In the present study, we examined the potential of neural crest tissue-derived periodontal ligament (PDL) iPSC to differentiate into neural crest-like cells (NCLC) relative to iPSC generated from a non-neural crest derived tissue, foreskin fibroblasts (FF)...
May 21, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27178356/lngfr-thy-1-human-pluripotent-stem-cell-derived-neural-crest-like-cells-have-the-potential-to-develop-into-mesenchymal-stem-cells
#3
Takehito Ouchi, Satoru Morikawa, Shinsuke Shibata, Kimiko Fukuda, Hironobu Okuno, Takumi Fujimura, Tatsuo Kuroda, Manabu Ohyama, Wado Akamatsu, Taneaki Nakagawa, Hideyuki Okano
Mesenchymal stem cells (MSCs) are defined as non-hematopoietic, plastic-adherent, self-renewing cells that are capable of tri-lineage differentiation into bone, cartilage or fat in vitro. Thus, MSCs are promising candidates for cell-based medicine. However, classifications of MSCs have been defined retrospectively; moreover, this conventional criterion may be inaccurate due to contamination with other hematopoietic lineage cells. Human MSCs can be enriched by selection for LNGFR and THY-1, and this population may be analogous to murine PDGFRα(+)Sca-1(+) cells, which are developmentally derived from neural crest cells (NCCs)...
December 2016: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27095857/effect-of-trifluoperazine-on-tc-99m-sestamibi-uptake-in-patients-with-advanced-nonsmall-cell-lung-cancer
#4
Ümmühan Abdülrezzak, Zeynep Erdoğan, Güler Silov, Ayşegül Özdal, Özgül Turhal
OBJECTIVE: The aim of this study was to investigate whether there is an effect of trifluoperazine on Tc-99m  methoxyisobutylisonitrile (MIBI) uptake in patients with advanced nonsmall cell lung cancer (NCLC). MATERIALS AND METHODS: A total of 23 patients with biopsy-proven advanced NCLC who had no previous history of chemo-radiotherapy, underwent baseline dual phase planar, single photon emission computed tomography and whole body Tc-99m MIBI scintigraphy performed at 20 and 120 min...
April 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/26913450/call-for-workshop-proposals-2017-acc-rac-wfc-nclc
#5
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Journal of Chiropractic Education
https://www.readbyqxmd.com/read/26913449/call-for-scientific-submissions-2017-acc-rac-wfc-nclc
#6
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Journal of Chiropractic Education
https://www.readbyqxmd.com/read/24518900/determining-progrp-and-isoforms-in-lung-and-thyroid-cancer-patient-samples-comparing-an-ms-method-with-a-routine-clinical-immunoassay
#7
COMPARATIVE STUDY
Silje Bøen Torsetnes, Marianne Nordlund Broughton, Elisabeth Paus, Trine Grønhaug Halvorsen, Léon Reubsaet
This paper compares two methods to determine the tumor marker progastrin-releasing peptide (ProGRP): as routine assay, the automated time-resolved immunofluorometric assay (TR-IFMA), which allows total ProGRP determination; and the immunocapture liquid chromatography selected reaction monitoring mass spectrometry (LC-SRM-MS) method, which additionally allows isoform differentiation. The investigation included 60 serum samples from patients suffering from various cancer diseases which may cause elevated ProGRP levels (small cell lung carcinoma; SCLC, non-small cell lung carcinoma; NCLC; and medullary thyroid cancer; MTC, as well as some with unspecific diagnosis)...
April 2014: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/24242882/nanoscale-separations-combined-with-electrospray-ionization-mass-spectrometry-sulfonamide-determination
#8
J R Perkins, C E Parker, K B Tomer
Nanoscale capillary liquid chromatography (nCLC) and capillary zone electrophoresis (CZE) have been combined with quadrupole mass spectrometry via an electrospray ionization (ESI) interface. These methodologies have been applied to the separation and determination of a variety of sulfonamides. CZE/ESI/MS is the more rapid and sensitive technique, but nCLC/ESI/MS shows promise for the analysis of dilute samples. Ultimately, the two techniques provide complementary methods of analysis. The detection limits of these techniques in the full-scan mode are in the low picomole range...
February 1992: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/22414251/incremental-evolution-of-the-neural-crest-neural-crest-cells-and-neural-crest-derived-skeletal-tissues
#9
REVIEW
Brian K Hall, J Andrew Gillis
Urochordates (ascidians) have recently supplanted cephalochordates (amphioxus) as the extant sister taxon of vertebrates. Given that urochordates possess migratory cells that have been classified as 'neural crest-like'- and that cephalochordates lack such cells--this phylogenetic hypothesis may have significant implications with respect to the origin of the neural crest and neural crest-derived skeletal tissues in vertebrates. We present an overview of the genes and gene regulatory network associated with specification of the neural crest in vertebrates...
January 2013: Journal of Anatomy
https://www.readbyqxmd.com/read/22085204/differentiation-of-induced-pluripotent-stem-cells-into-dental-mesenchymal-cells
#10
Keishi Otsu, Ryota Kishigami, Ai Oikawa-Sasaki, Satoshi Fukumoto, Aya Yamada, Naoki Fujiwara, Kiyoto Ishizeki, Hidemitsu Harada
Similar to embryonic stem cells, induced pluripotent stem (iPS) cells can differentiate into various cell types upon appropriate induction, and thus, may be valuable cell sources for regenerative medicine. However, iPS cells have not been reported to differentiate into odontogenic cells for tooth regeneration. Here we demonstrated that neural crest-like cells (NCLC) derived from mouse iPS cells have the potential to differentiate into odontogenic mesenchymal cells. We developed an efficient culture protocol to induce the differentiation of mouse iPS cells into NCLC...
May 1, 2012: Stem Cells and Development
https://www.readbyqxmd.com/read/19009978/government-health-workers-as-implementers-of-prevention-of-disability-measures-an-assessment-of-a-prevention-of-disability-project-in-selected-counties-of-guizhou-province-peoples-republic-of-china
#11
Jinlan Li, Hongjiang Mu, Wei Ke, Xia Bao, Ying Wang, Li Mei Shen, Hugh Cross
OBJECTIVE: The purpose of this study was to assess the effectiveness of government health workers as agents for the prevention of disability. DESIGN: A prevention of disability (POD) project for people affected by leprosy was conducted in nine counties of Guizhou Province, Peoples' Republic of China. The project was implemented by government health workers. In accordance with the principles and national criteria of the National Centre for Leprosy Control (NCLC) POD Pilot programme, 1215 people affected by leprosy were selected, followed up and assessed with the use of impairment summary forms through which essential indicators were routinely collected...
September 2008: Leprosy Review
https://www.readbyqxmd.com/read/18801357/trunk-lateral-cells-are-neural-crest-like-cells-in-the-ascidian-ciona-intestinalis-insights-into-the-ancestry-and-evolution-of-the-neural-crest
#12
William R Jeffery, Takuto Chiba, Florian Razy Krajka, Carole Deyts, Nori Satoh, Jean-Stéphane Joly
Neural crest-like cells (NCLC) that express the HNK-1 antigen and form body pigment cells were previously identified in diverse ascidian species. Here we investigate the embryonic origin, migratory activity, and neural crest related gene expression patterns of NCLC in the ascidian Ciona intestinalis. HNK-1 expression first appeared at about the time of larval hatching in dorsal cells of the posterior trunk. In swimming tadpoles, HNK-1 positive cells began to migrate, and after metamorphosis they were localized in the oral and atrial siphons, branchial gill slits, endostyle, and gut...
December 1, 2008: Developmental Biology
https://www.readbyqxmd.com/read/17509911/chordate-ancestry-of-the-neural-crest-new-insights-from-ascidians
#13
REVIEW
William R Jeffery
This article reviews new insights from ascidians on the ancestry of vertebrate neural crest (NC) cells. Ascidians have neural crest-like cells (NCLC), which migrate from the dorsal midline, express some of the typical NC markers, and develop into body pigment cells. These characters suggest that primordial NC cells were already present in the common ancestor of the vertebrates and urochordates, which have been recently inferred as sister groups. The primitive role of NCLC may have been in pigment cell dispersal and development...
August 2007: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/16432830/unexpected-long-term-survival-after-low-dose-palliative-radiotherapy-for-non-small-cell-lung-cancer
#14
Michael P Mac Manus, Jane P Matthews, Morikatsu Wada, Andrew Wirth, Valentina Worotniuk, David L Ball
BACKGROUND: Many experienced oncologists have encountered patients with proven non-small cell lung cancer (NCLC) who received modest doses of palliative radiotherapy (RT) and who unexpectedly survived for > 5 years; some were apparently cured. We used a very large prospective database to estimate the frequency of this phenomenon and to look for correlative prognostic factors. METHODS: Patients with histologically or cytologically proven NSCLC, treated with palliative RT to a dose of < or = 36 Gy, were identified from a prospective database containing details of 3035 new patients registered from 1984-1990...
March 1, 2006: Cancer
https://www.readbyqxmd.com/read/15900595/identification-of-postoperative-adjuvant-chemotherapy-responders-in-non-small-cell-lung-cancer-by-novel-biomarker
#15
Takashi Hirano, Harubumi Kato, Masahiro Maeda, Yunbo Gong, Yanning Shou, Miho Nakamura, Junichi Maeda, Koichi Yashima, Yasufumi Kato, Shingo Akimoto, Tatsuo Ohira, Masahiro Tsuboi, Norihiko Ikeda
Cisplatin-based (CDDP-based) adjuvant chemotherapy of non-small cell lung cancer (NSCLC) was reported to yield 5-15% improvement in 5-year survival compared to complete resection alone. The importance of information concerning preselection of good responders has become increasingly evident. The purpose of our study is the establishment of a preselection of good responders for CDDP-based adjuvant chemotherapy. We investigated protein expressions comparing intensity between parent strains (H69 and PC14 lung cancer cultured cells) and resistant strains against CDDP using 2-dimensional polyacrylamide gel electrophoresis (2-DE)...
November 10, 2005: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/11889698/-correlation-between-proliferative-processes-and-cell-death-in-non-small-cell-lung-cancer-with-glandular-differentiation-at-different-stages-of-tumor-progression
#16
E A Kogan, D A Ugriumov
Surgical material (removed lungs or their parts) from 58 patients operated in 1993-1998 was investigated. Lung adenocarcinomas (LAC) are characterized by low proliferative activity of tumor cells. With a decrease of LAC differentiation, tumor cell death by terminal differentiation also diminished which was accompanied by low bcl-2 expression and enhancement of spontaneous apoptosis with active accumulation of protein products of p53 expression in tumor cells nuclei. Expression of c-myc and bax remained unchanged...
January 2002: Arkhiv Patologii
https://www.readbyqxmd.com/read/11375684/5-5-bridged-bis-1-2-3-dithiazoles-spin-states-and-charge-transfer-chemistry
#17
T M Barclay, L Beer, A W Cordes, R T Oakley, K E Preuss, R W Reed, N J Taylor
Bifunctional 1,2,3-dithiazoles bridged with azine and phenylenediamine spacers have been prepared, with a view to determining the extent of communication between the two dithiazole rings as a function of the electronic and steric demands of the bridge. The crystal structure of the closed-shell diazine derivative [S(2)NClC(2)=NN=C(2)ClNS(2)] is rigorously planar. Cyclic voltammetry on this compound indicates two reversible one-electron oxidations. The radical cation state has been characterized by EPR spectroscopy and by crystal structure determination of its 1:1 PF(6)(-) salt...
June 4, 2001: Inorganic Chemistry
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