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https://www.readbyqxmd.com/read/27856795/an-injectable-shear-thinning-biomaterial-for-endovascular-embolization
#1
Reginald K Avery, Hassan Albadawi, Mohsen Akbari, Yu Shrike Zhang, Michael J Duggan, Dushyant V Sahani, Bradley D Olsen, Ali Khademhosseini, Rahmi Oklu
Improved endovascular embolization of vascular conditions can generate better patient outcomes and minimize the need for repeat procedures. However, many embolic materials, such as metallic coils or liquid embolic agents, are associated with limitations and complications such as breakthrough bleeding, coil migration, coil compaction, recanalization, adhesion of the catheter to the embolic agent, or toxicity. Here, we engineered a shear-thinning biomaterial (STB), a nanocomposite hydrogel containing gelatin and silicate nanoplatelets, to function as an embolic agent for endovascular embolization procedures...
November 16, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27809224/air-embolism-practical-tips-for-prevention-and-treatment
#2
REVIEW
Colin J McCarthy, Sasan Behravesh, Sailendra G Naidu, Rahmi Oklu
Air embolism is a rarely encountered but much dreaded complication of surgical procedures that can cause serious harm, including death. Cases that involve the use of endovascular techniques have a higher risk of air embolism; therefore, a heightened awareness of this complication is warranted. In particular, central venous catheters and arterial catheters that are often placed and removed in most hospitals by a variety of medical practitioners are at especially high risk for air embolism. With appropriate precautions and techniques it can be preventable...
October 31, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27796535/the-essentials-of-parathyroid-hormone-venous-sampling
#3
Bedros Taslakian, Scott O Trerotola, Barry Sacks, Rahmi Oklu, Amy Deipolyi
Hyperparathyroidism is an excess of parathyroid hormone in the blood due to over-activity of one or more parathyroid gland. Localization of abnormal glands with noninvasive imaging modalities, such as technetium sestamibi scan and cross-sectional imaging, has a high success rate. Parathyroid venous sampling is performed for patients with persistent or recurrent disease after previous parathyroid surgery, when repeat noninvasive imaging studies are negative or discordant. The success of invasive localization studies and results interpretation is dependent on the interventional radiologist's understanding of the normal and ectopic anatomic locations of parathyroid glands, as well as their blood supply and venous drainage...
October 28, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27776698/ethyl-pyruvate-modulates-delayed-paralysis-following-thoracic-aortic-ischemia-reperfusion-in-mice
#4
Bao-Ngoc Nguyen, Hassan Albadawi, Rahmi Oklu, Robert S Crawford, Mitchell P Fink, Richard P Cambria, Michael T Watkins
OBJECTIVE: Delayed paralysis is an unpredictable problem for patients undergoing complex repair of the thoracic/thoracoabdominal aorta. These experiments were designed to determine whether ethyl pyruvate (EP), a potent anti-inflammatory and antioxidant agent, might ameliorate delayed paralysis following thoracic aortic ischemia reperfusion (TAR). METHODS: C57BL6 mice were subjected to 5 minutes of thoracic aortic ischemia followed by reperfusion for up to 48 hours...
November 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27722710/bioprinted-thrombosis-on-a-chip
#5
Yu Shrike Zhang, Farideh Davoudi, Philipp Walch, Amir Manbachi, Xuan Luo, Valeria Dell'Erba, Amir K Miri, Hassan Albadawi, Andrea Arneri, Xiaoyun Li, Xiaoying Wang, Mehmet Remzi Dokmeci, Ali Khademhosseini, Rahmi Oklu
Pathologic thrombosis kills more people than cancer and trauma combined; it is associated with significant disability and morbidity, and represents a major healthcare burden. Despite advancements in medical therapies and imaging, there is often incomplete resolution of the thrombus. The residual thrombus can undergo fibrotic changes over time through infiltration of fibroblasts from the surrounding tissues and eventually transform into a permanent clot often associated with post-thrombotic syndrome. In order to understand the importance of cellular interactions and the impact of potential therapeutics to treat thrombosis, an in vitro platform using human cells and blood components would be beneficial...
October 18, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27509542/spinal-cord-inflammation-molecular-imaging-after-thoracic-aortic-ischemia-reperfusion-injury
#6
Hassan Albadawi, John W Chen, Rahmi Oklu, Yue Wu, Gregory Wojtkiewicz, Benjamin Pulli, John D Milner, Richard P Cambria, Michael T Watkins
Purpose To evaluate whether noninvasive molecular imaging technologies targeting myeloperoxidase (MPO) can reveal early inflammation associated with spinal cord injury after thoracic aortic ischemia-reperfusion (TAR) in mice. Materials and Methods The study was approved by the institutional animal care and use committee. C57BL6 mice that were 8-10 weeks old underwent TAR (n = 55) or sham (n = 26) surgery. Magnetic resonance (MR) imaging (n = 6) or single photon emission computed tomography (SPECT)/computed tomography (CT) (n = 15) studies targeting MPO activity were performed after intravenous injection of MPO sensors (bis-5-hydroxytryptamide-tetraazacyclododecane [HT]-diethyneletriaminepentaacetic acid [DTPA]-gadolinium or indium 111-bis-5-HT-DTPA, respectively)...
August 10, 2016: Radiology
https://www.readbyqxmd.com/read/27338307/use-of-magnetic-resonance-venography-in-screening-patients-with-cryptogenic-stroke-for-may-thurner-syndrome
#7
Anand M Prabhakar, Alexander S Misono, Katelyn N Brinegar, Ali Khademhosseini, Rahmi Oklu
The purpose of this study was to determine the prevalence of May-Thurner syndrome (MTS) in patients with cryptogenic stroke and to determine the incidence of patent foramen ovale. Magnetic resonance venography of 214 patients with cryptogenic stroke and 50 control patients with abdominopelvic computed tomography scans were evaluated for MTS. Incidence of patent foramen ovale and MTS in the stroke group were significantly greater than the control group (P = 0.0001, P = 0.0023, respectively). In addition, there was significantly greater compression of the left common iliac vein in the stroke group (32%) compared with the control group (13%) (P < 0...
April 27, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/27325468/transarterial-chemoembolization-in-the-coming-era-of-decreased-reimbursement-for-readmissions
#8
Colin J McCarthy, Andrew X Zhu, Shehab A Alansari, Rahmi Oklu
PURPOSE: CMS has identified readmission of patients within 30 days of discharge as a targeted quality metric and has instituted financial penalties to encourage hospitals to reduce readmissions. The aims of this study were to examine the rate of 30-day admissions after transarterial chemoembolization (TACE) at a single institution and to identify potential factors associated with readmission. METHODS: A total of 275 patients were identified who underwent a total of 457 TACE procedures over a 21-year period...
August 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27133696/imaging-findings-diagnosis-and-clinical-outcomes-in-patients-with-mycotic-aneurysms-single-center-experience
#9
Amy R Deipolyi, Alexander Bailin, Ali Khademhosseini, Rahmi Oklu
PURPOSE: To review the presentation, imaging, clinical management, and outcomes in patients with mycotic aneurysm (MA). METHODS: Fifty-five cases in 49 patients (33 men, 16 women, average age: 66.2years) were identified. RESULTS: Of 49 patients, only 20% presented with the classic clinical triad of fever, elevated white count, and pain. Computed tomography was the most utilized imaging modality; focal vascular outpouching was the most frequent imaging finding (76%)...
May 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27130587/critical-access-hospital-ed-to-quaternary-medical-center-successful-implementation-of-an-integrated-picture-archiving-and-communications-system-for-patient-transfers-by-air-and-sea
#10
Anand M Prabhakar, H Benjamin Harvey, Katelyn N Brinegar, Ali S Raja, James R Kelly, James A Brink, Sanjay Saini, Rahmi Oklu
PURPOSE: The purpose of this study was to investigate the role of imaging in transfers between an island Critical Access Hospital (CAH) emergency department (ED) and a quaternary care hospital. METHODS: Electronic medical records were reviewed to identify all patients who were transferred from an island CAH to our quaternary care hospital in 2012 and 2013. Medical history, transfer diagnosis, and the type of imaging performed at the CAH prior to transfer were reviewed...
August 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27126775/3d-bioprinting-for-tissue-and-organ-fabrication
#11
Yu Shrike Zhang, Kan Yue, Julio Aleman, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht, Jingzhou Yang, Weitao Jia, Valeria Dell'Erba, Pribpandao Assawes, Su Ryon Shin, Mehmet Remzi Dokmeci, Rahmi Oklu, Ali Khademhosseini
The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs...
April 28, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27117948/three-dimensional-printing-an-enabling-technology-for-ir
#12
REVIEW
Rahul Sheth, Elie R Balesh, Yu Shrike Zhang, Joshua A Hirsch, Ali Khademhosseini, Rahmi Oklu
Rapid prototyping, also known as three-dimensional (3D) printing, is a recent technologic advancement with tremendous potential for advancing medical device design. A wide range of raw materials can be incorporated into complex 3D structures, including plastics, metals, biocompatible polymers, and even living cells. With its promise of highly customized, adaptable, and personalized device design at the point of care, 3D printing stands to revolutionize medical care. The present review summarizes the methods for 3D printing and their current and potential roles in medical device design, with an emphasis on their potential relevance to interventional radiology...
June 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27084783/biomarkers-and-diagnostic-tools-for-detection-of-helicobacter-pylori
#13
REVIEW
Akbar Khalilpour, Mehdi Kazemzadeh-Narbat, Ali Tamayol, Rahmi Oklu, Ali Khademhosseini
Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. H. pylori is associated with significant morbidity and mortality including gastric cancer. The infection has both direct and indirect impacts on economic and overall well-being of patients; hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits. Here, we briefly review general aspects of H. pylori infection and the diagnostic biomarkers used in laboratory tests today with a focus on the potential role of microfluidic systems in future immunodiagnosis platforms...
June 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27076197/sedation-shared-decision-making-in-ambulatory-venous-access-device-placement-effects-on-patient-choice-satisfaction-and-recovery-time
#14
Melissa D Chittle, Rahmi Oklu, Richard M Pino, Ping He, Robert M Sheridan, Joanne Martino, Joshua A Hirsch
This study was undertaken to determine the impact of shared decision-making when selecting a sedation option, from no sedation (local anesthetic), minimal sedation (anxiolysis with a benzodiazepine) or moderate sedation (benzodiazepine and opiate), for venous access device placement (port-a-cath and tunneled catheters) on patient choice, satisfaction and recovery time. This is an IRB-approved, HIPPA-compliant, retrospective study of 198 patients (18-85 years old, 60% female) presenting to an ambulatory vascular interventional radiology department for venous access device placement between 22 October 2014 and 7 October 2015...
August 2016: Vascular Medicine
https://www.readbyqxmd.com/read/27068509/extracellular-matrix-remodelling-in-response-to-venous-hypertension-proteomics-of-human-varicose-veins
#15
Javier Barallobre-Barreiro, Rahmi Oklu, Marc Lynch, Marika Fava, Ferheen Baig, Xiaoke Yin, Temo Barwari, David N Potier, Hassan Albadawi, Marjan Jahangiri, Karen E Porter, Michael T Watkins, Sanjay Misra, Julianne Stoughton, Manuel Mayr
AIMS: Extracellular matrix remodelling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date, no systematic analysis of matrix remodelling in human veins has been performed. METHODS AND RESULTS: To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix. Varicose saphenous veins removed during phlebectomy and normal saphenous veins obtained during coronary artery bypass surgery were collected for proteomics analysis...
June 1, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27051417/thermal-ablative-therapies-and-immune-checkpoint-modulation-can-locoregional-approaches-effect-a-systemic-response
#16
REVIEW
Amol Mehta, Rahmi Oklu, Rahul A Sheth
Percutaneous image-guided ablation is an increasingly common treatment for a multitude of solid organ malignancies. While historically these techniques have been restricted to the management of small, unresectable tumors, there is an expanding appreciation for the systemic effects these locoregional interventions can cause. In this review, we summarize the mechanisms of action for the most common thermal ablation modalities and highlight the key advances in knowledge regarding the interactions between thermal ablation and the immune system...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/26995583/diagnosis-and-management-of-mycotic-aneurysms
#17
REVIEW
Amy R Deipolyi, Jun Rho, Ali Khademhosseini, Rahmi Oklu
Mycotic aneurysm (MA) is a focal dilation of an infected arterial wall. This uncommon disease follows an aggressive, unpredictable clinical course with significant mortality and presents unique diagnostic and therapeutic challenges. This review discusses the pathogenesis and the diagnostic challenges of MA.
March 2016: Clinical Imaging
https://www.readbyqxmd.com/read/26880723/bilateral-inferior-petrosal-sinus-sampling-experience-in-327-patients
#18
Amy Deipolyi, Alexander Bailin, Joshua A Hirsch, T Gregory Walker, Rahmi Oklu
OBJECTIVE: To describe findings and outcomes of 331 bilateral inferior petrosal sinus sampling (BIPSS) procedures performed in 327 patients evaluated for Cushing disease (CD). MATERIALS AND METHODS: The radiology department's electronic database was searched to identify all BIPSS procedures (1990-2013). Electronic medical records were used to identify demographics, laboratory, procedural, surgical and pathologic findings. RESULTS: A total of 331 BIPSS procedures were performed in 327 patients (254 F, 73 M), mean age 41 (range 7-81) years...
February 15, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/26876805/the-role-of-physical-stabilization-in-whole-blood-preservation
#19
Keith H K Wong, Rebecca D Sandlin, Thomas R Carey, Kathleen L Miller, Aaron T Shank, Rahmi Oklu, Shyamala Maheswaran, Daniel A Haber, Daniel Irimia, Shannon L Stott, Mehmet Toner
The rapid degradation of blood ex vivo imposes logistical limitations on the utilization of blood-borne cells in medical diagnostics and scientific investigations. A fundamental but overlooked aspect in the storage of this fluid tissue is blood settling, which induces physical stress and compaction, aggregates blood cells, and causes collateral damage due to leukocyte activation. Here we show that the polymer Ficoll 70 kDa stabilized blood samples and prevented blood settling over the course of 72 hours, primarily by inhibiting depletion-mediated red blood cell aggregation...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26797289/capillary-plexuses-are-vulnerable-to-neutrophil-extracellular-traps
#20
Leo Boneschansker, Yoshitaka Inoue, Rahmi Oklu, Daniel Irimia
Capillary plexuses are commonly regarded as reliable networks for blood flow and robust oxygen delivery to hypoxia sensitive tissues. They have high levels of redundancy to assure adequate blood supply when one or more of the capillaries in the network are blocked by a clot. However, despite having extensive capillary plexuses, many vital organs are often subject to secondary organ injury in patients with severe inflammation. Recent studies have suggested that neutrophils play a role in this pathology, even though their precise contribution remains elusive...
February 2016: Integrative Biology: Quantitative Biosciences From Nano to Macro
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