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Kidney biomarker

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https://www.readbyqxmd.com/read/29775888/therapeutic-impact-of-rhuepo-on-abnormal-platelet-app-bace-1-presenilin-1-adam-10-and-a%C3%AE-expressions-in-chronic-kidney-disease-patients-with-cognitive-dysfunction-like-alzheimer-s-disease-a-pilot-study
#1
Vinothkumar G, Krishnakumar S, Sureshkumar, Shivashekar G, Sreedhar S, Preethikrishnan, Dinesh S, Sundaram A, Balakrishnan D, Riya, Venkataraman P
BACKGROUND: Cognitive dysfunction is reported to be a major cause of morbidity in chronic kidney disease (CKD). The senile plaques (SPs) in the brain are one of the most pathophysiological characteristics of cognitive dysfunction and its major constituent amyloid β (Aβ) released from amyloid precursor protein (APP) by β (BACE1) and γ (presenilin 1) secretases . Platelets contain more than 95% of the circulating APP and implicate as a candidate biomarker for cognitive decline. Recombinant human erythropoietin (rHuEPO) is a standard therapy for anemia in CKD and also acts as a neuroprotective agent...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775220/cystatin-c-is-a-more-reliable-biomarker-for-determining-egfr-to-support-drug-development-studies
#2
REVIEW
Sumit Kar, Sabina Paglialunga, Rafiqul Islam
Glomerular filtration rate (GFR) is routinely used as a surrogate endpoint for the development of investigational drugs in clinical trials. GFR and staging of chronic kidney disease are typically assessed by measuring the concentration of endogenous serum biomarkers such as albumin and creatinine. However, creatinine is subject to high biological variability, and levels of creatinine do not rise until nearly 50% of kidney function is damaged, leading to inaccurate chronic kidney disease staging and false negatives...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29773494/plin3-is-up-regulated-and-correlates-with-poor-prognosis-in-clear-cell-renal-cell-carcinoma
#3
Keshan Wang, HaiLong Ruan, ZhengShuai Song, Qi Cao, Lin Bao, Di Liu, TianBo Xu, HaiBing Xiao, Cheng Wang, Gong Cheng, JunWei Tong, XianGui Meng, HongMei Yang, Ke Chen, XiaoPing Zhang
BACKGROUND: PLIN3, one of the members of the perilipin family, has been reported to be involved in the formation and accumulation of lipid droplets. However, the expression levels and diagnostic and prognostic value of PLIN3 in renal cell carcinoma (RCC) remain unclear. METHODS: Bioinformatic analysis was used to assess the levels of PLIN3 and the correlation between PLIN3 levels and clinicopathological parameters in renal cancer. The expression levels of PLIN3 were determined in human RCC tissues and cell lines by western blot, immunofluorescence and immunohistochemistry assays...
May 14, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29771425/fhl2-participates-in-renal-interstitial-fibrosis-by-altering-the-phenotype-of-renal-tubular-epithelial-cells-via-regulating-the-%C3%AE-catenin-pathway
#4
S-G Zhou, H-J Ma, Z-Y Guo, W Zhang, X Yang
OBJECTIVE: To investigate the potential role of FHL2 (four and a half LIM domains protein 2) in the renal interstitial fibrosis and its underlying mechanism. MATERIALS AND METHODS: NRK-52E, the rat tubular epithelial cell line, was selected for the in vitro experiments. The unilateral ureteral obstruction (UUO) mouse model and phenotype changes of NRK-52E cells were induced by TGF-β (transforming growth factor-β) treatment. Protein and mRNA expressions of biomarkers of tubular cells and renal fibrosis in NRK-52E cells were detected...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771383/relationship-of-fibroblast-growth-factor-21-with-kidney-function-and-albuminuria-multi-ethnic-study-of-atherosclerosis
#5
Sahapab Anuwatmatee, Matthew A Allison, Michael G Shlipak, Robyn L McClelland, Holly Kramer, Shudi Tang, Liming Hou, Kerry-Anne Rye, Kwok Leung Ong
Background: Fibroblast growth factor 21 (FGF21) may play a role in the development of chronic kidney disease (CKD). We therefore investigated the relationship of plasma FGF21 levels with kidney function and albuminuria in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: The analysis included 5724 MESA participants ages 45-84 years between 2000 and 2002, free of clinically apparent cardiovascular disease (CVD). Participants were followed up in person at four additional clinic visits over 10 years...
May 15, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29768022/a-pharmaceutical-industry-perspective-on-transporter-and-cyp-mediated-drug-drug-interactions-kidney-transporter-biomarkers
#6
Hong Shen
No abstract text is available yet for this article.
May 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29767638/pre-exposure-prophylaxis-with-tenofovir-disoproxil-fumarate-emtricitabine-and-kidney-tubular-dysfunction-in-hiv-uninfected-individuals
#7
Vasantha Jotwani, Rebecca Scherzer, David V Glidden, Megha Mehrotra, Patricia Defechereux, Albert Liu, Monica Gandhi, Michael Bennett, Steven G Coca, Chirag R Parikh, Robert M Grant, Michael G Shlipak
BACKGROUND: Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is becoming increasingly adopted for HIV prevention. Tenofovir can cause proximal tubular damage and chronic kidney disease in HIV-infected persons, but little is known regarding its nephrotoxic potential among HIV-uninfected persons. In this study, we evaluated the effects of PrEP on urine levels of the following: α1-microglobulin (α1m), a marker of impaired tubular reabsorption; albuminuria, a measure of glomerular injury; and total proteinuria...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29766170/design-of-a-wearable-device-for-real-time-screening-of-urinary-tract-infection-and-kidney-disease-based-on-smartphone
#8
Jianyu Zhou, Tao Dong
In this study, we developed a novel wearable and low-cost device for qualitative screening of glucose (GLU), leukocytes (LEU), and nitrite (NIT) and for semi-quantitative analysis of blood (BLD) and proteins (PRO) in the urine samples. The device can be attached to a diaper, and the results can be read by an app. The main functions of the device can be divided into sample collection, valve closing, and pad saturation; the recorded times for valve closing and pad saturation at four corners and pad saturation at the central parts are pseudo-medians (Hodges-Lehmann estimator) of 3...
May 16, 2018: Analyst
https://www.readbyqxmd.com/read/29764395/longitudinal-changes-in-bone-and-mineral-metabolism-after-cessation-of-cinacalcet-in-dialysis-patients-with-secondary-hyperparathyroidism
#9
Irene Ruderman, Edward R Smith, Nigel D Toussaint, Tim D Hewitson, Stephen G Holt
BACKGROUND: The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to assess effects of medication cessation on biochemical and clinical outcomes in dialysis patients, including changes to novel biomarkers such as calciprotein particles (CPP). CPP are nanoparticles of mineral and protein in the circulation associated with increased vascular calcification in patients with chronic kidney disease...
May 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29761868/evaluating-the-use-of-kim-1-in-drug-development-and-research-following-fda-qualification
#10
Ru Chen, Sarmistha Sanyal, Aliza Thompson, Joachim H Ix, Kylie Haskins, Laurie Muldowney, Shashi Amur
The Biomarker Qualification Program was established at the Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA) to expedite the integration of promising biomarkers across multiple drug development programs. The first set of biomarkers qualified in 2008 consisted of seven nonclinical safety biomarkers for the detection of acute drug-induced nephrotoxicity in rats, and included urinary kidney injury molecule-1 (KIM-1). This article discusses the use of KIM-1 in drug development and research before and after CDER's qualification of KIM-1...
May 15, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29761376/measurement-of-urinary-biomarkers-in-a-case-of-tubulointerstitial-nephritis-and-uveitis-syndrome-during-glucocorticoid-treatment
#11
Masafumi Sugiyama
Tubulointerstitial nephritis and uveitis (TINU) is a rare syndrome in which idiopathic interstitial nephritis coexists with chronic recurrent uveitis. This syndrome often represents systemic disorders such as arthralgia, rash, prolonged fever, anaemia and ocular symptoms that require medication including glucocorticoid administration. Recently, novel urinary biomarkers, such as kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and liver-type fatty acid-binding protein, were shown to be associated with tubulointerstitial damage and were elevated in interstitial nephritis...
May 14, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29759735/preoperative-serum-st2-level-predicts-acute-kidney-injury-after-adult-cardiac-surgery
#12
Kevin W Lobdell, Devin M Parker, Donald S Likosky, Michael Rezaee, Moritz Wyler von Ballmoos, Shama S Alam, Sherry Owens, Heather Thiessen-Philbrook, Todd MacKenzie, Jeremiah R Brown
OBJECTIVE: The purpose of this study was to evaluate the relationship between preoperative levels of serum soluble ST2 (ST2) and acute kidney injury (AKI) after cardiac surgery. Previous research has shown that biomarkers facilitate the prediction of AKI and other complications after cardiac surgery. METHODS: Preoperative ST2 proteins were measured in 1498 patients undergoing isolated coronary artery bypass graft surgery at 8 hospitals participating in the Northern New England Biomarker Study from 2004 to 2007...
April 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29758204/association-between-hippuric-acid-and-left-ventricular-hypertrophy-in-maintenance-hemodialysis-patients
#13
Teng-Hung Yu, Wei-Hua Tang, Yung-Chuan Lu, Chao-Ping Wang, Wei-Chin Hung, Cheng-Ching Wu, I-Ting Tsai, Fu-Mei Chung, Jer-Yiing Houng, Wen-Chun Lan, Yau-Jiunn Lee
BACKGROUND: Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end-stage renal disease. Hippuric acid (HA), a harmful uremic toxin, is known to be elevated in patients with uremia, and serum HA levels are associated with neurological symptoms, metabolic acidosis, and accelerated renal damage associated with chronic kidney disease. However, the pathophysiological role of HA in patients with uremia remains unclear. We investigated the association between serum HA levels and echocardiographic measurements in patients undergoing hemodialysis (HD) treatment...
May 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29758129/twenty-four-hour-normothermic-perfusion-of-discarded-human-kidneys-with-urine-recirculation
#14
Annemarie Weissenbacher, Letizia Lo Faro, Olga Boubriak, Maria F Soares, Ian S Roberts, James P Hunter, Daniel Voyce, Nikolay Mikov, Andrew Cook, Rutger J Ploeg, Constantin C Coussios, Peter J Friend
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ utilization and improved transplantation logistics. Eleven clinically-declined kidneys were perfused normothermically, six from donors after brain stem death (DBD, median cold ischemia time 33±36.9 hours) and five from donors after circulatory death (DCD, 36.2±38.3 hours): n=3 kidneys were perfused using Ringer's lactate to replace excreted urine volume, and n=8 using urine recirculation to maintain perfusate volume without fluid replenishment...
May 14, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29753670/intraoperative-renal-resistive-index-as-an-acute-kidney-injury-biomarker-development-and-validation-of-an-automated-analysis-algorithm
#15
Benjamin Y Andrew, Elias Y Andrew, Anne D Cherry, Jennifer N Hauck, Alina Nicoara, Carl F Pieper, Mark Stafford-Smith
OBJECTIVE: Intraoperative Doppler-determined renal resistive index (RRI) is a promising early acute kidney injury (AKI) biomarker. As RRI continues to be studied, its clinical usefulness and robustness in research settings will be linked to the ease, efficiency, and precision with which it can be interpreted. Therefore, the authors assessed the usefulness of computer vision technology as an approach to developing an automated RRI-estimating algorithm with equivalent reliability and reproducibility to human experts...
April 4, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29751827/timp-2-igfbp7-predicts-acute-kidney-injury-in-out-of-hospital-cardiac-arrest-survivors
#16
Christoph Adler, Tobias Heller, Felix Schregel, Henning Hagmann, Martin Hellmich, Joana Adler, Hannes Reuter
BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiopulmonary resuscitation (CPR) and predicts in-hospital mortality. To which extent post-resuscitation disease or the initial event of cardiac arrest and the duration of insufficient cardiac output triggers AKI is challenging to discriminate. Knowledge on molecular mediators of AKI is scarce. Early identification of patients at high risk of AKI is hampered by the low sensitivity of the established tests in clinical routine practice...
May 12, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29751071/protective-effects-of-a-natural-herbal-compound-quercetin-against-snake-venom-induced-hepatic-and-renal-toxicities-in-rats
#17
Abdulrahman K Al-Asmari, Haseeb A Khan, Rajamohamed A Manthiri, Ahmad A Al-Khlaiwi, Bayan A Al-Asmari, Khalid E Ibrahim
Echis pyramidum is a highly poisonous viper snake. Previous studies have shown acute phase hepatic and renal toxicities of Echis pyramidum venom (EPV) in rats. This study reports the protective effects of a natural herbal compound quercetin (QRC) on EPV-induced hepatic and renal toxicities in rats. A singly injection of EPV (4.76 mg/kg) caused significant increase in serum biomarkers of liver and kidney function. Pre-treatment of QRC (10 mg/kg) significantly reduced the toxic effects of EPV on functional impairment in liver and kidneys of rats...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29750148/expression-and-regulation-profile-of-mature-microrna-in-the-pig-relevance-to-xenotransplantation
#18
REVIEW
Zongpei Song, David K C Cooper, Zhiming Cai, Lisha Mou
The pig is an important source of meat production and provides a valuable model for certain human diseases. MicroRNA (miRNA), which is noncoding RNA and regulates gene expression at the posttranscriptional level, plays a critical role in various biological processes. Studies on identification and function of mature miRNAs in multiple pig tissues are increasing, yet the literature is limited. Therefore, we reviewed current research to determine the miRNAs expressed in specific pig tissues that are involved in carcass values (including muscle and adipocytes), reproduction (including pituitary, testis, and ovary), and development of some solid organs (e...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29749987/the-preventive-role-of-pioglitazone-in-glycerol-induced-acute-kidney-injury-in-rats-during-two-different-treatment-periods
#19
Rama Mousleh, Shaza Al Laham, Ahmad Al-Manadili
Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period. Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days)...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29748326/a-novel-method-for-rapid-bedside-measurement-of-gfr
#20
Dana V Rizk, Daniel Meier, Ruben M Sandoval, Teresa Chacana, Erinn S Reilly, Jesse C Seegmiller, Emmanuel DeNoia, James S Strickland, Joseph Muldoon, Bruce A Molitoris
Background Direct quantitative measurement of GFR (mGFR) remains a specialized task primarily performed in research settings. Multiple formulas for estimating GFR have been developed that use the readily available endogenous biomarkers creatinine and/or cystatin C. However, eGFR formulas have limitations, and an accurate mGFR is necessary in some clinical situations and for certain patient populations. We conducted a prospective, open-label study to evaluate a novel rapid technique for determining plasma volume and mGFR...
May 10, 2018: Journal of the American Society of Nephrology: JASN
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